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Gene Dmel\Poxn

General Information
Symbol	Dmel\Poxn	Species	D. melanogaster
Name	Pox neuro	Annotation symbol	CG8246
Feature type	protein_coding_gene	FlyBase ID	FBgn0003130
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	Pox-n
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	52C7-52C7	Sequence location	2R:11,714,198..11,722,560 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Pox neuro is referred to in FlyBase by the symbol Dmel\Poxn (CG8246, FBgn0003130). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: sequence-specific DNA binding transcription factor activity. There is experimental evidence that it is involved in the biological process: sensory organ development; antennal morphogenesis; adult feeding behavior; imaginal disc-derived wing morphogenesis; imaginal disc-derived leg morphogenesis; response to water stimulus; male courtship behavior. 37 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; adult segment; peripheral nervous system; organ system; thoracic segment; gustatory sensory organ; external compound sense organ; appendage segment; integumentary specialisation; abdominal 4 ventral sensillum campaniformium vc5; abdominal 7 ventral sensillum campaniformium vc5; metathoracic posterior fascicle neuron. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Homeodomain-like; Paired domain; Winged helix-turn-helix transcription repressor DNA-binding domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of extremely low expression. Peak expression observed within 06-24 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1632977_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Poxn. Gene sequence location is 2R:11714198..11722560.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	Pox-n: Paired box-neuro Pox-n shows tissue-specific, segmentally-repeated expression in the central and peripheral nervous system at about 5 hr after fertilization. Transcripts are apparently expressed in neural precursors of the peripheral and the central nervous system. Cells expressing this gene seem to be clonally related.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 52C7-52C7   Limits computationally determined from genome sequence between P{lacW}Vha36k07207 and P{lacW}l(2)k05713k05713
Experimentally Determined Cytological Location
Cytogenetic map Notes References 52D1-52D1     (Awasaki et al., 1996) 52D1-52D1   (determined by in situ hybridisation)   (Dambly-Chaudiere et al., 1992)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Poxn for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.44 Gene model reviewed during 5.50
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Poxn-RA FBtr0087311  NM_057338   2320   425 Poxn-RB FBtr0329908  NM_001274087   2458   425
Additional Transcript Data & Comments
Reported size (kB)	2.5 (northern blot) (Dambly-Chaudiere et al., 1992)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Poxn-PA   FBpp0086446   44.3   425   6.44     NP_476686   AAF58104 Poxn-PB   FBpp0302942   44.3   425   6.44     NP_001261016   AGB93548
Additional Polypeptide Data & Comments
Reported size (kDa)	425 (aa) (Bopp et al., 1989, Dambly-Chaudiere et al., 1992)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Paired domain (IPR001523) Homeodomain-like (IPR009057) Winged helix-turn-helix DNA-binding domain (IPR011991)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF58104   AC006090   AC007122   AE013599 AGB93548   BT022136   M86927 AAA28832   X58917 CAA41721
UniProtKB/Swiss-Prot	P23758
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References regulatory region FBsf0000435159 2R:11,722,280..11,722,780 evidence=Reporter construct (in vivo) (Boll and Noll, 2002, Halfon, 2012.6.19) regulatory region FBsf0000435589 2R:11,721,935..11,725,554 evidence=Reporter construct (in vivo) (Boll and Noll, 2002, Halfon, 2012.6.19) regulatory region FBsf0000435672 2R:11,725,554..11,726,807 evidence=Reporter construct (in vivo) (Boll and Noll, 2002, Halfon, 2012.6.19) regulatory region FBsf0000435941 2R:11,724,006..11,726,807 evidence=Reporter construct (in vivo) (Boll and Noll, 2002, Halfon, 2012.6.19) regulatory region FBsf0000435965 2R:11,728,004..11,730,757 evidence=Reporter construct (in vivo) (Boll and Noll, 2002, Halfon, 2012.6.19) regulatory region FBsf0000436238 2R:11,717,878..11,724,006 evidence=Reporter construct (in vivo) (Boll and Noll, 2002, Halfon, 2012.6.19) regulatory region FBsf0000436343 2R:11,726,807..11,728,004 evidence=Reporter construct (in vivo) (Boll and Noll, 2002, Halfon, 2012.6.19) regulatory region FBsf0000436431 2R:11,725,554..11,730,757 evidence=Reporter construct (in vivo) (Boll and Noll, 2002, Halfon, 2012.6.19) regulatory region FBsf0000436571 2R:11,717,878..11,718,948 evidence=Reporter construct (in vivo) (Boll and Noll, 2002, Halfon, 2012.6.19)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   central nervous system | restricted   (Bopp et al., 1989) presumptive embryonic/larval peripheral nervous system | restricted   (Bopp et al., 1989) embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   antennal primordium   (Fisher et al., 2012) dorsal ectoderm   (Fisher et al., 2012) embryonic stage 11 -- 12   antennal primordium   (Fisher et al., 2012) dorsal sensory complex primordium   (Fisher et al., 2012) labial sensory complex primordium   (Fisher et al., 2012) labral sensory complex primordium   (Fisher et al., 2012) maxillary sensory complex primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   dorsal sensory complex proper primordium   (Fisher et al., 2012) Comment:reported as dorsal/lateral sensory complexes embryonic brain   (Fisher et al., 2012) embryonic dorsal epidermis   (Fisher et al., 2012) embryonic head sensory system   (Fisher et al., 2012) embryonic ventral epidermis   (Fisher et al., 2012) embryonic/larval posterior spiracle   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012) ventral sensory complex primordium   (Fisher et al., 2012)
Additional Descriptive Data
	Poxn transcripts are expressed in segmentally repeated pattern in neural precursors in both the CNS and PNS. (Bopp et al., 1989)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage | mid   neuroblast   (Dambly-Chaudiere et al., 1992) embryonic stage   mesothoracic lateral Kolbchen lbd   (Dambly-Chaudiere et al., 1992) embryonic stage 11 -- 13   central nervous system | segmentally repeated   (Dambly-Chaudiere et al., 1992) prepupal stage P1   organism   (Dambly-Chaudiere et al., 1992) immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage | mid   ganglion mother cell   (Dambly-Chaudiere et al., 1992) embryonic stage   central nervous system | restricted   (Bopp et al., 1989) presumptive embryonic/larval peripheral nervous system | restricted   (Bopp et al., 1989) presumptive embryonic/larval peripheral nervous system | segmentally repeated   (Dambly-Chaudiere et al., 1992) metathoracic lateral Kolbchen lbd   (Dambly-Chaudiere et al., 1992) embryonic stage 10 -- 11   procephalic neurogenic region | restricted   (Hirth et al., 2003) Comment:expressed in two stripes embryonic stage 13 -- 14   embryonic deuterocerebrum | posterior & restricted   (Hirth et al., 2003) Comment:transverse stripe at posterior border embryonic protocerebrum | posterior & restricted   (Hirth et al., 2003) embryonic/larval subesophageal ganglion | segmentally repeated   (Hirth et al., 2003) ventral nerve cord | segmentally repeated   (Hirth et al., 2003) third instar larval stage   wing margin bristle | precursor   (Dambly-Chaudiere et al., 1992) prepupal stage P1   organism   (Dambly-Chaudiere et al., 1992)
Additional Descriptive Data
	Poxn protein isexpressed in four clusters of cells per hemisegment, two each in the CNSand PNS. It is first expressed at ~5.5 hours of development in a few cellsin the gnathal segments and in a single cell of each thoracic andabdominal hemisegment. At ~5.75hr, when the single cell starts dividing, asecond, more ventral cell appears. At the same time, the first labelledneuroblasts appear in the CNS at the anterior boundary of eachhemisegment. These consist of a neuroblast or a neuroblast and its firstGMC in each hemisegment. During germ band retraction, the dorsal pair ofPNS cells migrate ventrally to assume lateral positions. At the fast stageof germ band shortening, the pattern comprises two clusters of <8 cells inthe PNS and two neuroblasts and descended cells. After stage 13, Poxnprotein is no longer detected. In the wing discs, expression is seen inthe precursors of the poly-innervated wing margin bristles which are alongthe anterior wing margin. With the exception of the Keilin\'s organs,expression is specific for poly-innervated sense organs. (Dambly-Chaudiere et al., 1992) Expression of Poxn begins at embryonic stages 10-11, in two stripes in the procephalic neurogenic region, which become restricted to the posterior protocerebrum and posterior deuterocerebrum. Poxn is expressed near sv, but never in the same cell. (Hirth et al., 2003) Poxn transcripts are expressed in segmentally repeated pattern in neural precursors in both the CNS and PNS. (Bopp et al., 1989)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
nucleus inferred from direct assay (Dambly-Chaudiere et al., 1992)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    26.675 Larval Midgut    5.8 Larval Hindgut    6 Larval Malpighian Tubules    7.9 Larval Fat Body    5.8 Larval Salivary Gland    9.5 Larval Trachea    16.575 Larval Carcass    46.975 Adult Head    12.1 Adult Eye    3.15 Adult Brain    34 Adult Thoracic-Abdominal Ganglion    10.2 Adult Crop    6.1 Adult Midgut    14.9 Adult Hindgut    4.9 Adult Malpighian Tubules    18 Adult Fat Body    12.4 Adult Salivary Gland    22.7 Adult Heart    4.55 Adult VirginFemale Spermatheca    7.3 Adult InseminatedFemale Spermatheca    9.1 Adult Ovary    4.6 Adult Testis    4.1 Adult Male Accessory Gland    10.3 Adult Carcass    12.7 Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    26.675 Larval Midgut    5.8 Larval Hindgut    6 Larval Malpighian Tubules    7.9 Larval Fat Body    5.8 Larval Salivary Gland    9.5 Larval Trachea    16.575 Larval Carcass    46.975 Adult Head    12.1 Adult Eye    3.15 Adult Brain    34 Adult Thoracic-Abdominal Ganglion    10.2 Adult Crop    6.1 Adult Midgut    14.9 Adult Hindgut    4.9 Adult Malpighian Tubules    18 Adult Fat Body    12.4 Adult Salivary Gland    22.7 Adult Heart    4.55 Adult VirginFemale Spermatheca    7.3 Adult InseminatedFemale Spermatheca    9.1 Adult Ovary    4.6 Adult Testis    4.1 Adult Male Accessory Gland    10.3 Adult Carcass    12.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    26.675 Larval Midgut    5.8 Larval Hindgut    6 Larval Malpighian Tubules    7.9 Larval Fat Body    5.8 Larval Salivary Gland    9.5 Larval Trachea    16.575 Larval Carcass    46.975 Adult Head    12.1 Adult Eye    3.15 Adult Brain    34 Adult Thoracic-Abdominal Ganglion    10.2 Adult Crop    6.1 Adult Midgut    14.9 Adult Hindgut    4.9 Adult Malpighian Tubules    18 Adult Fat Body    12.4 Adult Salivary Gland    22.7 Adult Heart    4.55 Adult VirginFemale Spermatheca    7.3 Adult InseminatedFemale Spermatheca    9.1 Adult Ovary    4.6 Adult Testis    4.1 Adult Male Accessory Gland    10.3 Adult Carcass    12.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    26.675 Larval Midgut    5.8 Larval Hindgut    6 Larval Malpighian Tubules    7.9 Larval Fat Body    5.8 Larval Salivary Gland    9.5 Larval Trachea    16.575 Larval Carcass    46.975 Adult Head    12.1 Adult Eye    3.15 Adult Brain    34 Adult Thoracic-Abdominal Ganglion    10.2 Adult Crop    6.1 Adult Midgut    14.9 Adult Hindgut    4.9 Adult Malpighian Tubules    18 Adult Fat Body    12.4 Adult Salivary Gland    22.7 Adult Heart    4.55 Adult VirginFemale Spermatheca    7.3 Adult InseminatedFemale Spermatheca    9.1 Adult Ovary    4.6 Adult Testis    4.1 Adult Male Accessory Gland    10.3 Adult Carcass    12.7 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    26.675 Larval Midgut    5.8 Larval Hindgut    6 Larval Malpighian Tubules    7.9 Larval Fat Body    5.8 Larval Salivary Gland    9.5 Larval Trachea    16.575 Larval Carcass    46.975 Adult Head    12.1 Adult Eye    3.15 Adult Brain    34 Adult Thoracic-Abdominal Ganglion    10.2 Adult Crop    6.1 Adult Midgut    14.9 Adult Hindgut    4.9 Adult Malpighian Tubules    18 Adult Fat Body    12.4 Adult Salivary Gland    22.7 Adult Heart    4.55 Adult VirginFemale Spermatheca    7.3 Adult InseminatedFemale Spermatheca    9.1 Adult Ovary    4.6 Adult Testis    4.1 Adult Male Accessory Gland    10.3 Adult Carcass    12.7 Expression Level Scale  None   Low  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    26.675 Larval Midgut    5.8 Larval Hindgut    6 Larval Malpighian Tubules    7.9 Larval Fat Body    5.8 Larval Salivary Gland    9.5 Larval Trachea    16.575 Larval Carcass    46.975 Adult Head    12.1 Adult Eye    3.15 Adult Brain    34 Adult Thoracic-Abdominal Ganglion    10.2 Adult Crop    6.1 Adult Midgut    14.9 Adult Hindgut    4.9 Adult Malpighian Tubules    18 Adult Fat Body    12.4 Adult Salivary Gland    22.7 Adult Heart    4.55 Adult VirginFemale Spermatheca    7.3 Adult InseminatedFemale Spermatheca    9.1 Adult Ovary    4.6 Adult Testis    4.1 Adult Male Accessory Gland    10.3 Adult Carcass    12.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    26.675 Larval Midgut    5.8 Larval Hindgut    6 Larval Malpighian Tubules    7.9 Larval Fat Body    5.8 Larval Salivary Gland    9.5 Larval Trachea    16.575 Larval Carcass    46.975 Adult Head    12.1 Adult Eye    3.15 Adult Brain    34 Adult Thoracic-Abdominal Ganglion    10.2 Adult Crop    6.1 Adult Midgut    14.9 Adult Hindgut    4.9 Adult Malpighian Tubules    18 Adult Fat Body    12.4 Adult Salivary Gland    22.7 Adult Heart    4.55 Adult VirginFemale Spermatheca    7.3 Adult InseminatedFemale Spermatheca    9.1 Adult Ovary    4.6 Adult Testis    4.1 Adult Male Accessory Gland    10.3 Adult Carcass    12.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    26.675 Larval Midgut    5.8 Larval Hindgut    6 Larval Malpighian Tubules    7.9 Larval Fat Body    5.8 Larval Salivary Gland    9.5 Larval Trachea    16.575 Larval Carcass    46.975 Adult Head    12.1 Adult Eye    3.15 Adult Brain    34 Adult Thoracic-Abdominal Ganglion    10.2 Adult Crop    6.1 Adult Midgut    14.9 Adult Hindgut    4.9 Adult Malpighian Tubules    18 Adult Fat Body    12.4 Adult Salivary Gland    22.7 Adult Heart    4.55 Adult VirginFemale Spermatheca    7.3 Adult InseminatedFemale Spermatheca    9.1 Adult Ovary    4.6 Adult Testis    4.1 Adult Male Accessory Gland    10.3 Adult Carcass    12.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    no informative data   NA  Eye    3.15   NA  Brain    34   26.675  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    no informative data   NA  Crop    6.1   5.8  Midgut    no informative data   6  Hindgut    4.9   7.9  Malpighian Tubules    no informative data   5.8  Fat Body    no informative data   9.5  Salivary Gland    no informative data   NA  Heart    4.55   16.575  Trachea    NA   NA  VirginFemale Spermatheca    7.3   NA  InseminatedFemale Spermatheca    9.1   NA  Ovary    4.6   NA  Testis    4.1   NA  Male Accessory Gland    no informative data   46.975  Carcass    no informative data FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    1 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    1 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    1 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    1 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    1 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    1 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    1 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    1 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of extremely low expression. Peak expression observed within 06-24 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    3 embryo 10-12hr    4 embryo 12-14hr    4 embryo 14-16hr    2 embryo 16-18hr    1 embryo 18-20hr    2 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    1 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    1 pupae 3d postWPP    0 pupae 4d postWPP    0 adult male 01day    0 adult male 05day    0 adult male 30day    0 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    3 embryo 10-12hr    4 embryo 12-14hr    4 embryo 14-16hr    2 embryo 16-18hr    1 embryo 18-20hr    2 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    1 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    1 pupae 3d postWPP    0 pupae 4d postWPP    0 adult male 01day    0 adult male 05day    0 adult male 30day    0 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    3 embryo 10-12hr    4 embryo 12-14hr    4 embryo 14-16hr    2 embryo 16-18hr    1 embryo 18-20hr    2 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    1 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    1 pupae 3d postWPP    0 pupae 4d postWPP    0 adult male 01day    0 adult male 05day    0 adult male 30day    0 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    3 embryo 10-12hr    4 embryo 12-14hr    4 embryo 14-16hr    2 embryo 16-18hr    1 embryo 18-20hr    2 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    1 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    1 pupae 3d postWPP    0 pupae 4d postWPP    0 adult male 01day    0 adult male 05day    0 adult male 30day    0 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    3 embryo 10-12hr    4 embryo 12-14hr    4 embryo 14-16hr    2 embryo 16-18hr    1 embryo 18-20hr    2 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    1 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    1 pupae 3d postWPP    0 pupae 4d postWPP    0 adult male 01day    0 adult male 05day    0 adult male 30day    0 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    3 embryo 10-12hr    4 embryo 12-14hr    4 embryo 14-16hr    2 embryo 16-18hr    1 embryo 18-20hr    2 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    1 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    1 pupae 3d postWPP    0 pupae 4d postWPP    0 adult male 01day    0 adult male 05day    0 adult male 30day    0 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    3 embryo 10-12hr    4 embryo 12-14hr    4 embryo 14-16hr    2 embryo 16-18hr    1 embryo 18-20hr    2 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    1 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    1 pupae 3d postWPP    0 pupae 4d postWPP    0 adult male 01day    0 adult male 05day    0 adult male 30day    0 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    3 embryo 10-12hr    4 embryo 12-14hr    4 embryo 14-16hr    2 embryo 16-18hr    1 embryo 18-20hr    2 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    1 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    1 pupae 3d postWPP    0 pupae 4d postWPP    0 adult male 01day    0 adult male 05day    0 adult male 30day    0 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    0 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    0 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    0 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    0 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    0 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    0 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    0 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    0 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_11 mE1_20_mRNA_expression_cluster_07
External Data & Images
Linkouts	BDGP expression data • IP01592 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003130 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8246-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | recessive Poxnhs.sev viable PoxnΔM22-B5 viable, with Scer\GAL4pnr-MD237 PoxnGD4405 Sterility Allele male sterile PoxnΔM22-B5 Other Phenotypes Allele courtship behavior defective | male PoxnΔM22-B5 courtship behavior defective | male, with PoxnΔM22-B5/PoxnΔPBs PoxnΔXBs courtship behavior defective | male (with PoxnΔM22-B5), with PoxnΔXBs PoxnΔPBs courtship behavior defective | male (with PoxnΔPBs), with PoxnΔXBs PoxnΔM22-B5 feeding behavior defective Poxn70-23 feeding behavior defective | adult stage Poxn70-23 flight defective PoxnΔM22-B5 mating defective | male PoxnΔM22-B5 proboscis extension reflex defective PoxnΔM22-B5 taste perception defective PoxnΔM22-B5 visible Poxnhs.sev visible, with Scer\GAL4ey.PH PoxnScer\UAS.cJa visible, with Scer\GAL4hs.2sev PoxnScer\UAS.cJa visible, with Scer\GAL4sv.PJ PoxnScer\UAS.cJa Phenotype manifest in Allele abdominal 1 v'es2 neuron Poxn70 abdominal 2 v'es2 neuron Poxn70 abdominal 3 v'es2 neuron Poxn70 abdominal 4 v'es2 neuron Poxn70 abdominal 5 v'es2 neuron Poxn70 abdominal 6 v'es2 neuron Poxn70 abdominal 7 v'es2 neuron Poxn70 abdominal dorsal sensillum trichodeum dh1 Poxn70 adult brain PoxnΔM22-B5 adult head, with Scer\GAL4ey.PH PoxnScer\UAS.cJa antenna, with Scer\GAL4ey.PH PoxnScer\UAS.cJa arista Poxn70 basal cylinder Poxn70 chemosensory sensory organ | adult stage | ectopic Poxnhs.sev chemosensory sensory organ | ectopic Poxnhs.sev chemosensory sensory organ | ectopic | larval stage Poxnhs.sev chemosensory ventral triple row bristle Poxn68 Poxn70 chordotonal organ Poxnhs.sev clasper PoxnΔM22-B5 cone cell Poxnhs.sev des2 neuron Poxn70 dorsal triple row PoxnΔM22-B5 Poxn68 Poxn70 external sensory organ Poxnhs.sev eye Poxnhs.sev eye, with Scer\GAL4ey.PH PoxnScer\UAS.cJa eye, with Scer\GAL4hs.2sev PoxnScer\UAS.cJa eye, with Scer\GAL4sv.PJ PoxnScer\UAS.cJa Kolbchen Poxn70 Poxna.hs Kolbchen | embryonic stage Poxnhs.sev labellar taste bristle PoxnΔM22-B5 larval abdominal segment & sensillum campaniformium | ectopic Poxn70 larval abdominal segment & sensillum trichodeum | ectopic Poxn70 larval thoracic segment & sensillum campaniformium | ectopic Poxn70 macrochaeta | ectopic Poxnhs.PN mechanosensory chaeta | ectopic PoxnΔM22-B5 mechanosensory sensory organ Poxnhs.sev mechanosensory sensory organ & tibia & adult Poxnhs.sev mechanosensory sensory organ & tibia & neuron & adult Poxnhs.sev mesothoracic lateral Kolbchen lbd Poxn70 mesothoracic leg sensillum & tibia Poxn68 Poxn70 mesothoracic leg taste bristle PoxnΔM22-B5 mesothoracic les3 neuron Poxn70 mesothoracic metatarsus Poxn70 mesothoracic tarsal segment 2 Poxn70 mesothoracic tarsal segment 3 Poxn70 mesothoracic tarsal segment 4 Poxn70 mesothoracic tarsal segment 5 Poxn70 mesothoracic tarsal segment & joint Poxn70 mesothoracic v'es3 neuron Poxn70 mesothoracic ventral Kolbchen vbd Poxn70 metathoracic lateral Kolbchen lbd Poxn70 metathoracic leg taste bristle PoxnΔM22-B5 metathoracic les3 neuron Poxn70 metathoracic v'es3 neuron Poxn70 metathoracic ventral Kolbchen vbd Poxn70 ommatidium Poxnhs.sev ommatidium, with Scer\GAL4hs.2sev PoxnScer\UAS.cJa ommatidium, with Scer\GAL4sv.PJ PoxnScer\UAS.cJa penis PoxnΔM22-B5 posterior lobe PoxnΔM22-B5 prothoracic leg taste bristle PoxnΔM22-B5 prothoracic ventral Kolbchen vbd Poxn70 sensillum campaniformium | ectopic | second instar larval stage Poxn70 sensillum campaniformium | ectopic | third instar larval stage Poxn70 sensillum trichodeum | second instar larval stage Poxn70 sensillum trichodeum | third instar larval stage Poxn70 sensory mother cell Poxn70 taste bristle (with Df(2R)WMG) PoxnΔM22-B5 wing hinge PoxnΔM22-B5 Poxn70 wing hinge & wing vein Poxn70 wing hinge & wing vein L5 Poxn70 wing vein Poxnhs.PN wing vein L3 Poxnhs.PN wing vein L3 & macrochaeta Poxnhs.PN
Classical Alleles ( 8 )
For All Classical Alleles Show
Allele of Poxn Class Mutagen Stocks Known lesion PoxnMB00113 1 -- Poxn70 amorphic allele - genetic evidence 0 -- Poxn68 hypomorphic allele - genetic evidence 0 -- Poxn70-23 0 -- Poxn70-28 0 -- Poxnunspecified 0 -- PoxnΔM22-103 0 -- PoxnΔM22-B5 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 29 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Poxn Class Mutagen Stocks Known lesion PoxnGD4405 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes PoxnJF02136 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes PoxnKK110524 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Poxna.hs in vitro construct - regulatory fusion 0 Yes PoxnBaK in vitro construct 0 Yes PoxnBasiK in vitro construct 0 Yes PoxnBsK in vitro construct 0 Yes PoxnC1 in vitro construct 0 Yes PoxnE77 in vitro construct 0 Yes PoxnEvK in vitro construct 0 Yes PoxnFull in vitro construct 0 Yes Poxnhs.PN in vitro construct - regulatory fusion 0 Yes Poxnhs.sev in vitro construct - regulatory fusion 0 Yes PoxnL1 in vitro construct 0 Yes PoxnP2 in vitro construct 0 Yes PoxnPK in vitro construct 0 Yes PoxnSaK in vitro construct 0 Yes PoxnScer\UAS.cJa in vitro construct - regulatory fusion 0 Yes PoxnScK in vitro construct 0 Yes PoxnSuperA in vitro construct - genomic fragment 0 Yes Poxnsv.PJ in vitro construct - regulatory fusion 0 Yes PoxnXK in vitro construct 0 Yes PoxnΔBH in vitro construct 0 Yes PoxnΔKBs in vitro construct 0 Yes PoxnΔKX in vitro construct 0 Yes PoxnΔPBs in vitro construct 0 Yes PoxnΔSH in vitro construct 0 Yes PoxnΔXBs in vitro construct 0 Yes PoxnΔXP in vitro construct 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)42WMG (Ishimoto et al., 2000) Df(2R)Exel7137 (Ryder, 2004.4.26) Df(2R)KL32 (Dambly-Chaudiere et al., 1992) Df(2R)WMG (Bopp et al., 1989, Dambly-Chaudiere et al., 1992, Awasaki and Kimura, 1997, Gautier et al., 1997) Df(2R)XTE-18 (Dambly-Chaudiere et al., 1992)
Not disrupted in	Df(2R)KL9 (Bopp et al., 1989) Df(2R)XTE-18 (Bopp et al., 1989, Awasaki and Kimura, 1997)
Partially disrupted in	Df(2R)KL32 (Awasaki and Kimura, 1997)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4405} NA P{KK110524} NA P{TRiP.JF02136} NA P{UAS-Poxn.J} NA heat-shock construct P{hsp(sE)-poxn} NA P{hs-Poxn.a} NA P{Poxnhs.P} NA characterization construct P{Poxn.BaK} NA P{Poxn.BasiK} NA P{Poxn.BsK} NA P{Poxn.C1} NA P{Poxn.E77} NA P{Poxn.EvK} NA P{Poxn.Full} NA P{Poxn.L1} NA P{Poxn.P2} NA P{Poxn.PK} NA P{Poxn.SaK} NA P{Poxn.ScK} NA P{Poxn.SuperA} NA P{Poxn.XK} NA P{Poxn.ΔBH} NA P{Poxn.ΔKBs} NA P{Poxn.ΔKX} NA P{Poxn.ΔPBs} NA P{Poxn.ΔSH} NA P{Poxn.ΔXBs} NA P{Poxn.ΔXP} NA P{Poxn-GAL4.6} NA P{Poxn-GAL4.9} NA P{Poxn-GAL4.13} NA P{Poxn-GAL4.14} NA P{Poxn-GAL4.581} NA P{Poxn-GAL4.BasiK} NA P{prd-GsbN+PoxnC} NA P{spa-Poxn.J} NA P{UAS-GsbN+PoxnC} NA P{UAS-PoxnN+GsbC} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap binary system Mi{ET1}PoxnMB00113 No
Gene Ontology: Function, Process & Cellular Component ( 12 unique terms )
Terms Based on Experimental Evidence ( 8 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
adult feeding behavior inferred from mutant phenotype (Mitri et al., 2009) antennal morphogenesis inferred from mutant phenotype (Awasaki and Kimura, 2001) imaginal disc-derived leg morphogenesis inferred from mutant phenotype (Awasaki and Kimura, 2001) imaginal disc-derived wing morphogenesis inferred from mutant phenotype (Awasaki and Kimura, 2001) male courtship behavior inferred from mutant phenotype (Boll and Noll, 2002) response to water stimulus inferred from direct assay (Chen et al., 2010) sensory organ development inferred from mutant phenotype (Awasaki and Kimura, 2001, Boll and Noll, 2002)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (Dambly-Chaudiere et al., 1992)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
DNA binding inferred from electronic annotation with InterPro:IPR001523 (FlyBase Curators et al., 2004-) sequence-specific DNA binding transcription factor activity inferred from sequence or structural similarity with mouse Pax5 (FlyBase, 1992-)
Biological Process
CV term Evidence References
nervous system development non-traceable author statement (Swiss-Prot Project Members, 1991.11.1) regulation of transcription, DNA-dependent inferred from sequence or structural similarity with mouse Pax5 (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 1991.11.1) sensory organ development non-traceable author statement (Swiss-Prot Project Members, 1991.11.1)
Cellular Component
CV term Evidence References
nucleus inferred from sequence or structural similarity with mouse Pax5 (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 1991.11.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Poxn - Arc1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Poxn - Arpc1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Poxn - Arpc2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Poxn - Arpc3A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Poxn - Arpc4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Poxn - Arpc5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Poxn - CG10641 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Poxn - CG7049 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Poxn - Ccs anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Poxn - RpS21 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Poxn - Tapδ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Poxn allele Gene References Poxnhs.sev sv (Jiao et al., 2001) PoxnScer\UAS.cJa CycE (Jiao et al., 2001) dm (Jiao et al., 2001) sv (Jiao et al., 2001) Poxnsv.PJ sv (Jiao et al., 2001)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62469 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0003130 DroID - A comprehensive database of gene and protein interactions. • FBgn0003130 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36741
Orthologs
OrthoDB Orthologs (18) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG647GDX Dipteran inclusive ortholog search EOG64F6KJ Insect inclusive ortholog search EOG60K6VQ Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search EOG61KB69
Orthologs in Drosophila Species (EOG647GDX)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Poxn     Drosophila simulans   Dsim\GD25595 Y   Drosophila sechellia   Dsec\GM20119 Y   Drosophila erecta   Dere\GG22332 Y   Drosophila virilis   Dvir\GJ18164 Y
Orthologs in non-Drosophila Dipterans (EOG64F6KJ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Anopheles gambiae Malaria mosquito  Agam\AGAP008818
Orthologs in non-Dipteran Insects (EOG60K6VQ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB53602   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG005994   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH10993   Atta cephalotes Leafcutter ant  Acep\ACEP20052   Camponotus floridanus Florida carpenter ant  Cflo\CFLO14989   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL22907   Linepithema humile Argentine ant  Lhum\LH19067   Pogonomyrmex barbatus Red harvester ant  Pbar\PB25982   Solenopsis invicta Red fire ant  Sinv\SINV20844   Pediculus humanus Human body louse  Phum\PHUM404840   Tribolium castaneum Red flour beetle  Tcas\Poxn
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (EOG61KB69)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_027334gn
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD25595 Drosophila sechellia Dsec\GM20119 Drosophila erecta Dere\GG22332 Drosophila yakuba Dyak\GE14129 Drosophila ananassae Dana\GF13369 Drosophila pseudoobscura pseudoobscura Dpse\GA20926 Drosophila persimilis Dper\GL11851 Drosophila willistoni Dwil\GK19611 Drosophila virilis Dvir\GJ18164 Drosophila mojavensis Dmoj\GI19757 Drosophila grimshawi Dgri\GH20564
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	26238 y1 v1; P{TRiP.JF02136}attP2 22701 y1 w67c23; Mi{ET1}PoxnMB00113
VDRC	v107471 P{KK110524}VIE-260B v10844 w1118 P{GD4405}v10844 v47609 w1118; P{GD4405}v47609
Genomic Clones ( 2 )
	BACR04J01 BACR07M03 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 2 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP01592
Other clones	DPiM_IP01592
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0003130 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36741
Antibody Information
	polyclonal (Bopp et al., 1989)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	Poxn is required for normal male courtship and fertility. Poxn function is required for the normal development of chemosensory bristles in the labellum, legs and wings. (Boll and Noll, 2002) Poxn is responsible for differentiating chemosensory organs from mechanosensory organs. (Dambly-Chaudiere, 1995) The Poxn protein binds to 40 sites on the polytene chromosomes. One of the sites corresponds to the ct locus. Poxn probably has a direct effect on the ct regulatory region. (Vervoort et al., 1995) Poxn expression is independent of ct but dependent on the achaete-scute complex. (Vervoort et al., 1995) The ectopic expression of Poxn transforms ch organs into es organs; this transformation can occur in achaete-scute complex- embryos but not in ct- embryos. (Vervoort et al., 1995) Poxn can control the number of neurons. Poxn can act at a late stage to affect the fate of the undifferentiated neuron. (Nottebohm et al., 1994) Ectopic expression of Poxn can induce the transformation of mechanosensory into chemosensory neurons. The neurons innervating the transformed organs follow a pathway typical of chemosensory neurons. Behavioural tests show that these neurons establish connections appropriate to taste-mediating bristles. (Nottebohm et al., 1993) Poxn gene product has been characterised and results demonstrate that the gene product is responsible for the poly innervated external sense organs. (Dambly-Chaudiere et al., 1992) In larvae, deletion of Poxn results in the morphological transformation of chemosensory into mechanosensory organs; an overexpression of the same gene induces the reciprocal transformation. Overexpression of Poxn induces the morphological transformation of mechanosensory into chemosensory bristles on the adult legs; the neurons innervating the morphologically transformed bristles follow pathways and establish connections that are appropriate for chemosensory bristles. (Nottebohm et al., 1992) Poxn was isolated as it shared a network specific domain with prd that specifies position along the antero posterior axis of the embryo. (Bopp et al., 1989)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057338 NM_001274087 RefSeq (Proteins) • NP_476686 NP_001261016 DDBJ / EMBL / GenBank • AAA28832 AAF58104 AC006090 AC007122 AGB93548 CAA41721 M86927 X58917 Entrez Gene - A searchable database of RefSeq genes. • 36741 UniProtKB/Swiss-Prot • P23758
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Paired domain (IPR001523) Homeodomain-like (IPR009057) Winged helix-turn-helix DNA-binding domain (IPR011991) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • IP01592
Linkouts
	BioGRID - A database of protein and genetic interactions • 62469 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0003130 DroID - A comprehensive database of gene and protein interactions. • FBgn0003130 DRSC - Results from RNAi screens. • FBgn0003130 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003130 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8246-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0003130 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36741 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /gene/pairboxn.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36741 modMine - Data generated by the modENCODE project. • FBgn0003130 REDfly - A database of transcriptional regulatory elements. • FBgn0003130
Synonyms & Secondary IDs ( 14 )
Reported As
Symbol Synonym	CG8246 (Perkins et al., 2009.3.31, Keleman et al., 2009.8.5) neuro (Balczarek et al., 1997) P4 (Bopp et al., 1989) poxn (Inoshita and Tanimura, 2006, Nakamura et al., 2002, Jiao et al., 2001, Ueno et al., 2001, Nepveu, 2001, Awasaki and Kimura, 2001, Ishimoto et al., 2000, Ghysen and Dambly-Chaudiere, 2000, Clyne et al., 2000, Hassanzadeh et al., 1998, Hassanzadeh et al., 1998, Dambly-Chaudiere and Vervoort, 1998, Ledent et al., 1998, Hirozane and Tanimura, 1997, Fu and Noll, 1997, Vervoort et al., 1997, Gautier et al., 1997, Awasaki and Kimura, 1997, Kimura and Awasaki, 1997, Awasaki et al., 1996, Vervoort et al., 1995, Jiang et al., 1995, Vervoort et al., 1995, Jiang et al., 1995, Nottebohm et al., 1993, Dambly-Chaudiere et al., 1991, Brcic-Kostic et al., 1994, Nottebohm et al., 1994, Ghysen and Dambly-Chaudiere, 1993, Jan and Jan, 1992, Dambly-Chaudiere et al., 1992, Morita et al., 2005, Layalle et al., 2004, Ebacher et al., 2007, Urbach, 2007, Barnes et al., 2008, Ben-Shahar and Welsh, 2008, Keleman et al., 2005, Keene et al., 2004, Usui-Aoki et al., 2005, Joseph et al., 2009, Mitri et al., 2009, Devineni and Heberlein, 2009, Moon et al., 2009, Cameron et al., 2010, Koganezawa and Shimada, 2002, Schneider et al., 2012) Pox-n (Butler et al., 2003, Lindsley and Zimm, 1992, Zhai et al., 2009) pox-n (Salzberg and Bellen, 1996, Jimenez and Modolell, 1993, Zhai et al., 2010) Poxn (Hoskins et al., 2005, Southall and Brand, 2009, Krstic et al., 2009, Lu et al., 2012, Copley, 2005, Joseph et al., 2009, Chen et al., 2010, Higashi-Kovtun et al., 2010, Beltran et al., 2007, Chatterjee et al., 2011, Usui-Aoki et al., 2005, Friedrich and Caravas, 2011, Ben-Shahar et al., 2010, McNeil et al., 2011)
Name Synonym	Paired box neural   Paired box-neuro (Lindsley and Zimm, 1992) pox-neural (Vaessin et al., 1991) pox-neuro (Smith, 2001, Jan and Jan, 1993, Goodman and Doe, 1993, Cabrera, 1992, Ghysen and Dambly-Chaudiere, 2000, Ebacher et al., 2007, Dus et al., 2011, Joseph et al., 2009, Mitri et al., 2009, Zhai et al., 2010) pox neuro (Vanario-Alonso et al., 1995, Patel, 1994, Devineni and Heberlein, 2009) Pox-neuro (Zhai et al., 2009) Pox neuro (Cho et al., 2005, Krstic et al., 2009, Chatterjee et al., 2011, Friedrich and Caravas, 2011)
Secondary FlyBase IDs
References ( 125 )
Generate a list of	All references relating to this gene ( 125 )
List References by type	Research paper  ( 70 ) Supplementary material  ( 5 ) Review  ( 18 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 15 ) FlyBase analysis  ( 2 ) Book  ( 1 ) Protein sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 7 )
	Joseph and Heberlein, 2012, Genetics 192(2): 521--532 Tissue-specific activation of a single gustatory receptor produces opposing behavioral responses in Drosophila. [FBrf0219596] Lu et al., 2012, PLoS Genet. 8(3): e1002587 ppk23-Dependent Chemosensory Functions Contribute to Courtship Behavior in Drosophila melanogaster. [FBrf0217844] Schneider et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109 Suppl 2: 17174--17179 Social structures depend on innate determinants and chemosensory processing in Drosophila. [FBrf0219728] Chatterjee et al., 2011, Development 138(6): 1099--1109 The female-specific Doublesex isoform regulates pleiotropic transcription factors to pattern genital development in Drosophila. [FBrf0213054] Dus et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(28): 11644--11649 Taste-independent detection of the caloric content of sugar in Drosophila. [FBrf0214346] Friedrich and Caravas, 2011, J. Exp. Zool. B Mol. Dev. Evol. 316(6): 387--392 New insights from hemichordate genomes: prebilaterian origin and parallel modifications in the paired domain of the Pax gene eyegone. [FBrf0214613] McNeil et al., 2011, G3 (Bethesda) 1(5): 343--351 Multiple Quantitative Trait Loci Influence the Shape of a Male-Specific Genital Structure in Drosophila melanogaster. [FBrf0217624] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...