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Gene Dmel\Pp1-13C

General Information
Symbol	Dmel\Pp1-13C	Species	D. melanogaster
Name	Protein phosphatase 1 at 13C	Annotation symbol	CG9156
Feature type	protein_coding_gene	FlyBase ID	FBgn0003132
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	PP1α13C, PP1, PP1 13C, PP1c, 13C
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	13B9-13B9	Sequence location	X:15,253,134..15,255,094 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Protein phosphatase 1 at 13C is referred to in FlyBase by the symbol Dmel\Pp1-13C (CG9156, FBgn0003132). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein serine/threonine phosphatase activity. There is experimental evidence that it is involved in the biological process: protein dephosphorylation; sperm competition; neurogenesis. 7 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Metallophosphoesterase domain; Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of no expression detected. Peak expression observed in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult testis. Comments on Affy2 ProbeSet: ProbeSet 1628164_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Pp1-13C. Gene sequence location is X:15253134..15255094.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	Pp1: Protein phosphatase 1 Encodes a protein phosphatase 1 catalytic subunit that shows a high degree of similarity to rabbit protein phosphatase 1α in its enzymatic and physiochemical characteristics and has a predicted protein sequence that is 92% identical to that of rabbit PP-1α.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02	Controlled Vocabulary Terms sperm competition
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 13B9-13B9   Limits computationally determined from genome sequence between P{EP}hiwEP1308 and P{EP}Ahcy13EP1007
Experimentally Determined Cytological Location
Cytogenetic map Notes References 13C-13C   (determined by in situ hybridisation)   (Dombradi et al., 1993)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Pp1-13C for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Pp1-13C-RA FBtr0074017  NM_080182   1892   302
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Pp1-13C-PA   FBpp0073834   34.6   302   5.47     NP_524921   AAF48448
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Metallophosphoesterase domain (IPR004843) Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase (IPR006186)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014298 AAF48448   AI133871   AI945848   AW940372   AY060272 AAL25311   AY061063   BF486783   BF502015   DQ443387   ES688842   ES688995   ES691442   ES691459   ES691469   ES691470   ES691476   ES691479   ES691510   ES691513   ES691517   ES691529   ES691976   ES691977   ES691981   ES694691   ES694725   ES694735   X69974 CAA49594
UniProtKB/Swiss-Prot	Q05547
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Dorus et al., 2006, Wasbrough et al., 2010) day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    3.525 Larval Midgut    4.8 Larval Hindgut    1.8 Larval Malpighian Tubules    4.6 Larval Fat Body    76.9 Larval Salivary Gland    3.6 Larval Trachea    4.775 Larval Carcass    1.4 Adult Head    1.8 Adult Eye    5.15 Adult Brain    5.8 Adult Thoracic-Abdominal Ganglion    4.2 Adult Crop    2.1 Adult Midgut    6 Adult Hindgut    1.9 Adult Malpighian Tubules    3.2 Adult Fat Body    4.3 Adult Salivary Gland    4.9 Adult Heart    3.425 Adult VirginFemale Spermatheca    1.9 Adult InseminatedFemale Spermatheca    3 Adult Ovary    1.4 Adult Testis    750.7 Adult Male Accessory Gland    2.3 Adult Carcass    3.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    3.525 Larval Midgut    4.8 Larval Hindgut    1.8 Larval Malpighian Tubules    4.6 Larval Fat Body    76.9 Larval Salivary Gland    3.6 Larval Trachea    4.775 Larval Carcass    1.4 Adult Head    1.8 Adult Eye    5.15 Adult Brain    5.8 Adult Thoracic-Abdominal Ganglion    4.2 Adult Crop    2.1 Adult Midgut    6 Adult Hindgut    1.9 Adult Malpighian Tubules    3.2 Adult Fat Body    4.3 Adult Salivary Gland    4.9 Adult Heart    3.425 Adult VirginFemale Spermatheca    1.9 Adult InseminatedFemale Spermatheca    3 Adult Ovary    1.4 Adult Testis  (750.7) Adult Male Accessory Gland    2.3 Adult Carcass    3.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    3.525 Larval Midgut    4.8 Larval Hindgut    1.8 Larval Malpighian Tubules    4.6 Larval Fat Body    76.9 Larval Salivary Gland    3.6 Larval Trachea    4.775 Larval Carcass    1.4 Adult Head    1.8 Adult Eye    5.15 Adult Brain    5.8 Adult Thoracic-Abdominal Ganglion    4.2 Adult Crop    2.1 Adult Midgut    6 Adult Hindgut    1.9 Adult Malpighian Tubules    3.2 Adult Fat Body    4.3 Adult Salivary Gland    4.9 Adult Heart    3.425 Adult VirginFemale Spermatheca    1.9 Adult InseminatedFemale Spermatheca    3 Adult Ovary    1.4 Adult Testis    750.7 Adult Male Accessory Gland    2.3 Adult Carcass    3.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    3.525 Larval Midgut    4.8 Larval Hindgut    1.8 Larval Malpighian Tubules    4.6 Larval Fat Body    76.9 Larval Salivary Gland    3.6 Larval Trachea    4.775 Larval Carcass    1.4 Adult Head    1.8 Adult Eye    5.15 Adult Brain    5.8 Adult Thoracic-Abdominal Ganglion    4.2 Adult Crop    2.1 Adult Midgut    6 Adult Hindgut    1.9 Adult Malpighian Tubules    3.2 Adult Fat Body    4.3 Adult Salivary Gland    4.9 Adult Heart    3.425 Adult VirginFemale Spermatheca    1.9 Adult InseminatedFemale Spermatheca    3 Adult Ovary    1.4 Adult Testis    750.7 Adult Male Accessory Gland    2.3 Adult Carcass    3.9 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    3.525 Larval Midgut    4.8 Larval Hindgut    1.8 Larval Malpighian Tubules    4.6 Larval Fat Body    76.9 Larval Salivary Gland    3.6 Larval Trachea    4.775 Larval Carcass    1.4 Adult Head    1.8 Adult Eye    5.15 Adult Brain    5.8 Adult Thoracic-Abdominal Ganglion    4.2 Adult Crop    2.1 Adult Midgut    6 Adult Hindgut    1.9 Adult Malpighian Tubules    3.2 Adult Fat Body    4.3 Adult Salivary Gland    4.9 Adult Heart    3.425 Adult VirginFemale Spermatheca    1.9 Adult InseminatedFemale Spermatheca    3 Adult Ovary    1.4 Adult Testis    750.7 Adult Male Accessory Gland    2.3 Adult Carcass    3.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    3.525 Larval Midgut    4.8 Larval Hindgut    1.8 Larval Malpighian Tubules    4.6 Larval Fat Body    76.9 Larval Salivary Gland    3.6 Larval Trachea    4.775 Larval Carcass    1.4 Adult Head    1.8 Adult Eye    5.15 Adult Brain    5.8 Adult Thoracic-Abdominal Ganglion    4.2 Adult Crop    2.1 Adult Midgut    6 Adult Hindgut    1.9 Adult Malpighian Tubules    3.2 Adult Fat Body    4.3 Adult Salivary Gland    4.9 Adult Heart    3.425 Adult VirginFemale Spermatheca    1.9 Adult InseminatedFemale Spermatheca    3 Adult Ovary    1.4 Adult Testis  750.7 Adult Male Accessory Gland    2.3 Adult Carcass    3.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    3.525 Larval Midgut    4.8 Larval Hindgut    1.8 Larval Malpighian Tubules    4.6 Larval Fat Body    76.9 Larval Salivary Gland    3.6 Larval Trachea    4.775 Larval Carcass    1.4 Adult Head    1.8 Adult Eye    5.15 Adult Brain    5.8 Adult Thoracic-Abdominal Ganglion    4.2 Adult Crop    2.1 Adult Midgut    6 Adult Hindgut    1.9 Adult Malpighian Tubules    3.2 Adult Fat Body    4.3 Adult Salivary Gland    4.9 Adult Heart    3.425 Adult VirginFemale Spermatheca    1.9 Adult InseminatedFemale Spermatheca    3 Adult Ovary    1.4 Adult Testis    750.7 Adult Male Accessory Gland    2.3 Adult Carcass    3.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    3.525 Larval Midgut    4.8 Larval Hindgut    1.8 Larval Malpighian Tubules    4.6 Larval Fat Body    76.9 Larval Salivary Gland    3.6 Larval Trachea    4.775 Larval Carcass    1.4 Adult Head    1.8 Adult Eye    5.15 Adult Brain    5.8 Adult Thoracic-Abdominal Ganglion    4.2 Adult Crop    2.1 Adult Midgut    6 Adult Hindgut    1.9 Adult Malpighian Tubules    3.2 Adult Fat Body    4.3 Adult Salivary Gland    4.9 Adult Heart    3.425 Adult VirginFemale Spermatheca    1.9 Adult InseminatedFemale Spermatheca    3 Adult Ovary    1.4 Adult Testis    750.7 Adult Male Accessory Gland    2.3 Adult Carcass    3.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    1.8   NA  Eye    5.15   NA  Brain    5.8   3.525  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    4.2   NA  Crop    2.1   4.8  Midgut    6   1.8  Hindgut    1.9   4.6  Malpighian Tubules    3.2   no informative data  Fat Body    4.3   3.6  Salivary Gland    4.9   NA  Heart    3.425   4.775  Trachea    NA   NA  VirginFemale Spermatheca    1.9   NA  InseminatedFemale Spermatheca    3   NA  Ovary    1.4   NA  Testis    750.7   NA  Male Accessory Gland    2.3   1.4  Carcass    3.9 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    31 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    4 fat body, pupae P8    6 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    64 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (31) central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    4 fat body, pupae P8    6 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male  (64) accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    31 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    4 fat body, pupae P8    6 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    64 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    31 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    4 fat body, pupae P8    6 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    64 accessory gland, mated 4-day male    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    31 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    4 fat body, pupae P8    6 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    64 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  31 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    4 fat body, pupae P8    6 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male  (64) accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    31 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    4 fat body, pupae P8    6 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    64 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    31 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    4 fat body, pupae P8    6 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    64 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of no expression detected. Peak expression observed in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    6 white prepupae 12hr    10 white prepupae 24hr    13 pupae 2d postWPP    18 pupae 3d postWPP    17 pupae 4d postWPP    15 adult male 01day    30 adult male 05day    36 adult male 30day    35 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    6 white prepupae 12hr    10 white prepupae 24hr    13 pupae 2d postWPP    18 pupae 3d postWPP    17 pupae 4d postWPP    15 adult male 01day  (30) adult male 05day  (36) adult male 30day  (35) adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    6 white prepupae 12hr    10 white prepupae 24hr    13 pupae 2d postWPP    18 pupae 3d postWPP    17 pupae 4d postWPP    15 adult male 01day    30 adult male 05day    36 adult male 30day    35 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    6 white prepupae 12hr    10 white prepupae 24hr    13 pupae 2d postWPP    18 pupae 3d postWPP    17 pupae 4d postWPP    15 adult male 01day    30 adult male 05day    36 adult male 30day    35 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    6 white prepupae 12hr    10 white prepupae 24hr    13 pupae 2d postWPP    18 pupae 3d postWPP    17 pupae 4d postWPP    15 adult male 01day    30 adult male 05day    36 adult male 30day    35 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    6 white prepupae 12hr    10 white prepupae 24hr    13 pupae 2d postWPP    18 pupae 3d postWPP    17 pupae 4d postWPP    15 adult male 01day  30 adult male 05day  (36) adult male 30day  (35) adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    6 white prepupae 12hr    10 white prepupae 24hr    13 pupae 2d postWPP    18 pupae 3d postWPP    17 pupae 4d postWPP    15 adult male 01day    30 adult male 05day    36 adult male 30day    35 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    6 white prepupae 12hr    10 white prepupae 24hr    13 pupae 2d postWPP    18 pupae 3d postWPP    17 pupae 4d postWPP    15 adult male 01day    30 adult male 05day    36 adult male 30day    35 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    0 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    0 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    0 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    0 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    0 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    0 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    0 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    0 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_33 mE1_20_mRNA_expression_cluster_19
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003132 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9156-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal Pp1-13CGD14139 lethal, with Scer\GAL4pnr-MD237 Pp1-13CGD14139 lethal | pupal stage, with Scer\GAL4pnr-MD237 Pp1-13CGD14139 Other Phenotypes Allele neuroanatomy defective | larval stage Pp1-13CGD14139 Phenotype manifest in Allele embryonic/larval neuroblast | larval stage Pp1-13CGD14139 ganglion mother cell | larval stage Pp1-13CGD14139
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of Pp1-13C Class Mutagen Stocks Known lesion Pp1-13C159 0 Yes Pp1-13CΔ402 0 Yes
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Pp1-13C Class Mutagen Stocks Known lesion Pp1-13CGD14139 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Pp1-13CHMS00465 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Pp1-13CKK105852 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Pp1-13CScer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion 1 Yes Pp1-13CNIG.9156R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD14139} NA P{KK105852} NA P{NIG.9156R} NA P{TRiP.HMS00465} NA P{UAS-Pp1-13C.HA} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function
CV term Evidence References
protein serine/threonine phosphatase activity inferred from direct assay (Dombradi et al., 1993)
Biological Process
CV term Evidence References
neurogenesis inferred from mutant phenotype (Neumüller et al., 2011) protein dephosphorylation inferred from direct assay (Dombradi et al., 1993) sperm competition inferred from mutant phenotype (Greenspan and Clark, 2011)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
protein serine/threonine phosphatase activity non-traceable author statement (Morrison et al., 2000, Swiss-Prot Project Members, 1996.2.1)
Biological Process
CV term Evidence References
protein dephosphorylation non-traceable author statement (Morrison et al., 2000, Swiss-Prot Project Members, 1996.2.1)
Cellular Component
CV term Evidence References
protein phosphatase type 1 complex inferred from sequence or structural similarity (Dombradi et al., 1993)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Pp1-13C - CG1532 experimental knowledge based (Guruharsha et al., 2011) Pp1-13C - CG18787 experimental knowledge based (Guruharsha et al., 2011) Pp1-13C - CG18789 experimental knowledge based (Guruharsha et al., 2011) Pp1-13C - CG7049 experimental knowledge based (Guruharsha et al., 2011) Pp1-13C - I-2 experimental knowledge based (Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Pp1-13C allele Gene References Pp1-13CScer\UAS.T:Ivir\HA1 NiPp1 (Parker et al., 2002, Bennett et al., 2003)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 71473 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0003132 DroID - A comprehensive database of gene and protein interactions. • FBgn0003132 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 48531 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q05547
Orthologs
OrthoDB Orthologs (56) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG69KG9N Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search EOG6XD2MT Arthropod inclusive ortholog search EOG60RXXC Metazoa inclusive ortholog search EOG6DVJF3
Orthologs in Drosophila Species (EOG69KG9N)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Pp1-13C     Drosophila simulans   Dsim\GD15806 Y   Drosophila sechellia   Dsec\GM23981 Y   Drosophila yakuba   Dyak\GE16053 Y   Drosophila ananassae   Dana\GF21042 Y   Drosophila willistoni   Dwil\GK20015 Y   Drosophila mojavensis   Dmoj\GI15416 Y   Drosophila grimshawi   Dgri\GH17947 Y
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (EOG6XD2MT)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC409430 Y Apis mellifera Western honey bee  Amel\LOC409804 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG004180 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG001441 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH19817 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH22552 Y Atta cephalotes Leafcutter ant  Acep\ACEP17433 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO16348 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO18880 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL22925 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL12906 Y Linepithema humile Argentine ant  Lhum\LH12603 Y Linepithema humile Argentine ant  Lhum\LH10743 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB14845 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB14481 Y Solenopsis invicta Red fire ant  Sinv\SINV10914 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI004455 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI005202 Y Bombyx mori Silkmoth  Bmor\BGIBMGA008501 Y Pediculus humanus Human body louse  Phum\PHUM570660 Y Tribolium castaneum Red flour beetle  Tcas\GLEAN_15321 Y Tribolium castaneum Red flour beetle  Tcas\GLEAN_08406 Y
Orthologs in non-Insect Arthropods (EOG60RXXC)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\CHS2 Y Daphnia pulex Water flea  Dpux\ZNF3 Y Ixodes scapularis Deer tick  Isca\ISCW012293 Y
Orthologs in non-Arthropod Metazoa (EOG6DVJF3)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\gsp-1 Y Caenorhabditis elegans Nematode  Cele\gsp-2 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_001788gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_008700gn Y Danio rerio Zebrafish  Drer\ppp1caa Y Danio rerio Zebrafish  Drer\ppp1cab Y Danio rerio Zebrafish  Drer\ppp1cb Y Danio rerio Zebrafish  Drer\ppp1cbl Y Danio rerio Zebrafish  Drer\ppp1cc Y Xenopus tropicalis Western clawed frog  Xtro\ppp1ca Y Xenopus tropicalis Western clawed frog  Xtro\ppp1cc Y Xenopus tropicalis Western clawed frog  Xtro\ppp1cb Y Gallus gallus Domestic chicken  Ggal\PPP1CB Y Gallus gallus Domestic chicken  Ggal\PPP1CC Y Mus musculus House mouse  Mmus\Ppp1ca Y Mus musculus House mouse  Mmus\Ppp1cb Y Mus musculus House mouse  Mmus\Ppp1cc Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000042597 Y Rattus norvegicus Norway rat  Rnor\Ppp1cb Y Rattus norvegicus Norway rat  Rnor\Ppp1ca Y Rattus norvegicus Norway rat  Rnor\Ppp1cc Y Homo sapiens Human  Hsap\PPP1CC Y Homo sapiens Human  Hsap\PPP1CA Y
Human Orthologs (2)
Gene OMIM HGNC Hsap\PPP1CC     Hsap\PPP1CA
AAA Orthologs (8) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD15806 Drosophila sechellia Dsec\GM23981 Drosophila yakuba Dyak\GE16053 Drosophila ananassae Dana\GF21042 Drosophila pseudoobscura pseudoobscura Dpse\GA26586 Drosophila willistoni Dwil\GK20015 Drosophila mojavensis Dmoj\GI15416 Drosophila grimshawi Dgri\GH17947
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	32465 y1 sc* v1; P{TRiP.HMS00465}attP2 23701 w*; P{UAS-Pp1-13C.HA}3/TM6C, cu1 Sb1
VDRC	v107770 P{KK105852}VIE-260B v29058 w1118; P{GD14139}v29058 v29057 w1118; P{GD14139}v29057/TM3
Genomic Clones ( 1 )
	BACR48D17 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 24 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH10637 LD03380
Other clones	DPiM_LD03380
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT17624 AT21311
Other clones	bs17e09 RC0-DA0001-120700-022-D01 RC0-DA0001-120700-022-H05 RC0-DA0001-120700-023-G04 RC0-DA0001-120700-024-D10 RC0-DA0001-120700-024-D11 RC0-DA0001-120700-024-F02 RC0-DA0001-120700-024-G07 RC0-DA0001-120700-026-B08 RC0-DA0001-120700-028-C11 RC0-DA0001-120700-028-D12 RC0-DA0001-120700-028-G08 RC0-DA0001-120700-029-H07 RC0-DA0001-130700-214-F02 RC0-DA0001-130700-214-G01 RC0-DA0001-130700-215-D08 RC0-DL0001-140700-022-F04 RC0-DL0001-140700-024-E06 RC0-DL0001-140700-025-E03
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0003132 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 48531
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Pp1-13C CG9156 (Bayraktaroglu, 2000.4.13)
Additional comments
Other Comments
	In a sample of 79 genes with multiple introns, 33 showed significant heterogeneity in G+C content among introns of the same gene and significant positive correspondence between the intron and the third codon position G+C content within genes. These results are consistent with selection adding against preferred codons at the start of genes. (Kliman and Eyre-Walker, 1998) Cloning and characterisation of Pp1-13C. (Dombradi et al., 1993)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080182 RefSeq (Proteins) • NP_524921 DDBJ / EMBL / GenBank • AAF48448 AAL25311 AI133871 AI945848 AW940372 AY060272 CAA49594 X69974 Entrez Gene - A searchable database of RefSeq genes. • 48531 UniProtKB/Swiss-Prot • Q05547
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Metallophosphoesterase domain (IPR004843) Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase (IPR006186)
Linkouts
	BioGRID - A database of protein and genetic interactions • 71473 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0003132 DroID - A comprehensive database of gene and protein interactions. • FBgn0003132 DRSC - Results from RNAi screens. • FBgn0003132 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003132 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9156-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0003132 FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways • 98700 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 48531 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 48531 modMine - Data generated by the modENCODE project. • FBgn0003132 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q05547
Synonyms & Secondary IDs ( 19 )
Reported As
Symbol Synonym	13C (Fang et al., 2007, Su et al., 2011) CG9156 (Morrison et al., 2000, Greenspan and Clark, 2011, Keleman et al., 2009.8.5, Ni et al., 2010.12.1, Cammarato et al., 2011, Wheeler et al., 2004) DmPp1-13C (Cohen, 2005) PP1 (Lioultcheva et al., 2002, Alphey et al., 2000, Helps et al., 1998, Fang et al., 2007, Tan et al., 2007) Pp1 (Henikoff, 1996, ) pp1-13C (Ceriani et al., 2002) PP1 13C (Morrison et al., 2000, Armstrong et al., 1998, Cohen, 1997, Dombradi et al., 1993, Chen et al., 1992) Pp1-13C (Kirchner, 2007.7.19, Dorus et al., 2006, Cash and Andrews, 2012, Fernández-Ayala et al., 2010, Wasbrough et al., 2010, Neumüller et al., 2011, Wheeler et al., 2004, Japanese National Institute of Genetics, 2012.5.21) PP1-13C (Asensio et al., 2010) PP1c (Rudenko et al., 2003, Bennett and Alphey, 2002, Rudenko et al., 2003) PP1α13C (Parker et al., 2002, Bennett et al., 2003, Bennett et al., 1999, Alphey et al., 1998, Kirchner et al., 2007, Swanhart et al., 2007, Kirchner et al., 2008, Bennett et al., 2006, Guruharsha et al., 2011) PP1α-13C (Rudenko et al., 2003) PP1α13C, (Bennett et al., 2006) PP1 β13c (Grusche et al., 2009) PP13C (Cohen, 1993.1.13) unnamed (Dombradi et al., 1989)
Name Synonym	protein phosphatase 1 (Fang et al., 2007) Protein phosphatase 1 13C (Cohen, 1993.1.13) Protein phosphatase 1 at 13C (Cammarato et al., 2011)
Secondary FlyBase IDs
	FBgn0030632
References ( 66 )
Generate a list of	All references relating to this gene ( 66 )
List References by type	Research paper  ( 30 ) Supplementary material  ( 10 ) Review  ( 4 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 7 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 1 ) Stock list  ( 1 ) Protein sequence record  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 6 )
	Zhang et al., 2013, Mol. Ecol. 22(5): 1400--1415 Natural genetic variation in male reproductive genes contributes to nontransitivity of sperm competitive ability in Drosophila melanogaster. [FBrf0220937] Cash and Andrews, 2012, BMC Dev. Biol. 12: 4 Fine scale analysis of gene expression in Drosophila melanogaster gonads reveals Programmed cell death 4 promotes the differentiation of female germline stem cells. [FBrf0217547] Greenspan and Clark, 2011, Int. J. Evol. Biol. 2011: 214280 Associations between Variation in X Chromosome Male Reproductive Genes and Sperm Competitive Ability in Drosophila melanogaster. [FBrf0214060] Guruharsha et al., 2011, Cell 147(3): 690--703 A Protein Complex Network of Drosophila melanogaster. [FBrf0216491] Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593 Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621] Su et al., 2011, Sci. Signal. 4(180): ra43 Sequential phosphorylation of smoothened transduces graded hedgehog signaling. [FBrf0216577] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...