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Gene Dmel\Pp1α-96A

General Information
Symbol	Dmel\Pp1α-96A	Species	D. melanogaster
Name	Protein phosphatase 1α at 96A	Annotation symbol	CG6593
Feature type	protein_coding_gene	FlyBase ID	FBgn0003134
Gene Model Status	Current	Stock availability	9 publicly available
Also Known As	PP1α96A, Pp1alpha-96A, Pp1-96A, PP1, PP1 96A, PP1c, 96A
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	96A5-96A5	Sequence location	3R:20,343,992..20,348,053 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Protein phosphatase 1α at 96A is referred to in FlyBase by the symbol Dmel\Pp1α-96A (CG6593, FBgn0003134). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: protein serine/threonine phosphatase activity. Based on sequence similarity, it is predicted to be involved in the biological process: protein dephosphorylation. 8 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Metallophosphoesterase domain; Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult crop, adult hindgut, adult fat body, adult salivary gland, adult spermathecae. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, larval hindgut, larval/adult Malpighian tubules, adult heart, larval fat body, larval salivary gland, larval trachea, adult ovary, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1625806_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Pp1alpha-96A. Gene sequence location is 3R:20343992..20348053.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	Pp1: Protein phosphatase 1 Encodes a protein phosphatase 1 catalytic subunit that shows a high degree of similarity to rabbit protein phosphatase 1α in its enzymatic and physiochemical characteristics and has a predicted protein sequence that is 92% identical to that of rabbit PP-1α.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 96A5-96A5   Limits computationally determined from genome sequence between P{PZ}crb07207&P{PZ}BRWD305842 and P{EP}CycB3EP3127
Experimentally Determined Cytological Location
Cytogenetic map Notes References 96A2-96A5   (determined by in situ hybridisation)   (Ranz et al., 1999) 96A2-96A5   (determined by in situ hybridisation)   (Dombradi et al., 1990)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Pp1α-96A for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.47 Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Pp1α-96A-RA FBtr0084642  NM_079760   2221   327 Pp1α-96A-RB FBtr0334334  NM_001275990   3210   327
Additional Transcript Data & Comments
Reported size (kB)	2.3 (northern blot) (Dombradi et al., 1990)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Pp1α-96A-PA   FBpp0084026   37.4   327   6.64     NP_524484   AAF56306 Pp1α-96A-PB   FBpp0306442   37.4   327   6.64     NP_001262919   AGB96299
Additional Polypeptide Data & Comments
Reported size (kDa)	327 (aa); 37.3 (kD predicted) (Dombradi et al., 1990)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Metallophosphoesterase domain (IPR004843) Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase (IPR006186)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201240   AA201823   AA264267   AA390447   AA390777   AA391115   AA567579   AA801708   AA802251   AA816256   AA816543   AA820128   AE014297 AAF56306   AE014297 AGB96299   AI063951   AI406126   AI534473   BG633607   BG635671   BG636362   BI173301   BI229597   BI231940   BI234144   BI234410   BI239246   BI241550   BI366709   BI372597   BI373614   BI485488   BI573413   BI573414   BI573415   BI577429   BI578849   BI638145   BI639455   BI640936   BI641492   BI641521   BQ103430   BT016110 AAV36995   CK133420   CL943541   CO186321   CO186793   CO193094   CO196094   CO265846   CO266384   CO271592   CO271664   CO275143   CO281932   CO286617   CO291776   CO292080   CO294170   CO294659   CO298171   CO303323   CO306772   CO318707   CO324266   CO327569   CO328251   CO329863   CO343171   CO343313   DQ440289   DQ443387   EC051091   EC051094   EC053350   EC054090   EC055940   EC056216   EC060116   EC060284   EC061563   EC063578   EC064152   EC065905   EC069354   EC071605   EC081965   EC194869   EC195951   EC199507   EC209166   EC211154   EC214673   EC215667   EC220452   EC235451   EC239366   EC240521   EC244030   EC248939   EC249567   EC253252   EC253703   EC255889   EC257744   EL870958   EL870959   EL879258   EL879369   EL879504   EL879623   EV576696   EV583312   EV587298   EV591909   EV592311   EV593110   EV594764   GH753196   GH754798   GH756304   GH758815   GH770345   GH771138   GH773489   GH773654   GH775895   GH776856   GH777215   GH779124   GH781773   GH788475   GH792414   GH796639   GH797686   GH797948   GH798712   GH799585   GH800227   GH800493   GH800721   GH803948   GH810046   GH810245   GH815061   GH816428   GH816759   GH816938   GH823776   GH829409   GH832607   GH837871   GH841415   GH845902   GH847350   GH852695   GH853052   GH854045   GH854137   GH854253   GH855981   GH857112   GH862119   GH866710   GH866888   GH866986   GH868886   GH874763   GH877480   GH879846   GH883878   GH885784   GH894112   GH898288   GH901194   GH901530   GH901760   GH904560   GH907576   GH923817   GH930723   GH932199   X56438 CAA39820
UniProtKB/Swiss-Prot	P48461
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   organism | ubiquitous   (Fisher et al., 2012) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage     (Dombradi et al., 1990) adult stage     (Dombradi et al., 1990)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult crop, adult hindgut, adult fat body, adult salivary gland, adult spermathecae. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, larval hindgut, larval/adult Malpighian tubules, adult heart, larval fat body, larval salivary gland, larval trachea, adult ovary, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    266.625 Larval Midgut    82.4 Larval Hindgut    227.3 Larval Malpighian Tubules    215.4 Larval Fat Body    201.1 Larval Salivary Gland    499.2 Larval Trachea    169.9 Larval Carcass    235.775 Adult Head    332.3 Adult Eye    249.7 Adult Brain    238 Adult Thoracic-Abdominal Ganglion    173.3 Adult Crop    1060.9 Adult Midgut    97.5 Adult Hindgut    520.4 Adult Malpighian Tubules    245 Adult Fat Body    1109.8 Adult Salivary Gland    548.1 Adult Heart    463.9 Adult VirginFemale Spermatheca    955.5 Adult InseminatedFemale Spermatheca    656.2 Adult Ovary    292.4 Adult Testis    120.6 Adult Male Accessory Gland    386.3 Adult Carcass    425.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    266.625 Larval Midgut    82.4 Larval Hindgut    227.3 Larval Malpighian Tubules    215.4 Larval Fat Body    201.1 Larval Salivary Gland    499.2 Larval Trachea    169.9 Larval Carcass    235.775 Adult Head    332.3 Adult Eye    249.7 Adult Brain    238 Adult Thoracic-Abdominal Ganglion    173.3 Adult Crop  (1060.9) Adult Midgut    97.5 Adult Hindgut  520.4 Adult Malpighian Tubules    245 Adult Fat Body  (1109.8) Adult Salivary Gland  (548.1) Adult Heart    463.9 Adult VirginFemale Spermatheca  (955.5) Adult InseminatedFemale Spermatheca  (656.2) Adult Ovary    292.4 Adult Testis    120.6 Adult Male Accessory Gland    386.3 Adult Carcass    425.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    266.625 Larval Midgut    82.4 Larval Hindgut    227.3 Larval Malpighian Tubules    215.4 Larval Fat Body    201.1 Larval Salivary Gland    499.2 Larval Trachea    169.9 Larval Carcass    235.775 Adult Head    332.3 Adult Eye    249.7 Adult Brain    238 Adult Thoracic-Abdominal Ganglion    173.3 Adult Crop  1060.9 Adult Midgut    97.5 Adult Hindgut    520.4 Adult Malpighian Tubules    245 Adult Fat Body  (1109.8) Adult Salivary Gland    548.1 Adult Heart    463.9 Adult VirginFemale Spermatheca    955.5 Adult InseminatedFemale Spermatheca    656.2 Adult Ovary    292.4 Adult Testis    120.6 Adult Male Accessory Gland    386.3 Adult Carcass    425.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    266.625 Larval Midgut    82.4 Larval Hindgut    227.3 Larval Malpighian Tubules    215.4 Larval Fat Body    201.1 Larval Salivary Gland    499.2 Larval Trachea    169.9 Larval Carcass    235.775 Adult Head    332.3 Adult Eye    249.7 Adult Brain    238 Adult Thoracic-Abdominal Ganglion    173.3 Adult Crop    1060.9 Adult Midgut    97.5 Adult Hindgut    520.4 Adult Malpighian Tubules    245 Adult Fat Body    1109.8 Adult Salivary Gland    548.1 Adult Heart    463.9 Adult VirginFemale Spermatheca    955.5 Adult InseminatedFemale Spermatheca    656.2 Adult Ovary    292.4 Adult Testis    120.6 Adult Male Accessory Gland    386.3 Adult Carcass    425.1 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    266.625 Larval Midgut    82.4 Larval Hindgut    227.3 Larval Malpighian Tubules    215.4 Larval Fat Body    201.1 Larval Salivary Gland    499.2 Larval Trachea    169.9 Larval Carcass    235.775 Adult Head    332.3 Adult Eye    249.7 Adult Brain    238 Adult Thoracic-Abdominal Ganglion    173.3 Adult Crop    1060.9 Adult Midgut    97.5 Adult Hindgut    520.4 Adult Malpighian Tubules    245 Adult Fat Body    1109.8 Adult Salivary Gland    548.1 Adult Heart    463.9 Adult VirginFemale Spermatheca    955.5 Adult InseminatedFemale Spermatheca    656.2 Adult Ovary    292.4 Adult Testis    120.6 Adult Male Accessory Gland    386.3 Adult Carcass    425.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    266.625 Larval Midgut    82.4 Larval Hindgut    227.3 Larval Malpighian Tubules    215.4 Larval Fat Body    201.1 Larval Salivary Gland    499.2 Larval Trachea    169.9 Larval Carcass    235.775 Adult Head    332.3 Adult Eye    249.7 Adult Brain    238 Adult Thoracic-Abdominal Ganglion    173.3 Adult Crop  (1060.9) Adult Midgut    97.5 Adult Hindgut  520.4 Adult Malpighian Tubules    245 Adult Fat Body  (1109.8) Adult Salivary Gland  548.1 Adult Heart    463.9 Adult VirginFemale Spermatheca  (955.5) Adult InseminatedFemale Spermatheca  656.2 Adult Ovary    292.4 Adult Testis    120.6 Adult Male Accessory Gland    386.3 Adult Carcass    425.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    266.625 Larval Midgut    82.4 Larval Hindgut    227.3 Larval Malpighian Tubules    215.4 Larval Fat Body    201.1 Larval Salivary Gland    499.2 Larval Trachea    169.9 Larval Carcass    235.775 Adult Head    332.3 Adult Eye    249.7 Adult Brain    238 Adult Thoracic-Abdominal Ganglion    173.3 Adult Crop  1060.9 Adult Midgut    97.5 Adult Hindgut    520.4 Adult Malpighian Tubules    245 Adult Fat Body  1109.8 Adult Salivary Gland    548.1 Adult Heart    463.9 Adult VirginFemale Spermatheca    955.5 Adult InseminatedFemale Spermatheca    656.2 Adult Ovary    292.4 Adult Testis    120.6 Adult Male Accessory Gland    386.3 Adult Carcass    425.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    266.625 Larval Midgut    82.4 Larval Hindgut    227.3 Larval Malpighian Tubules    215.4 Larval Fat Body    201.1 Larval Salivary Gland    499.2 Larval Trachea    169.9 Larval Carcass    235.775 Adult Head    332.3 Adult Eye    249.7 Adult Brain    238 Adult Thoracic-Abdominal Ganglion    173.3 Adult Crop    1060.9 Adult Midgut    97.5 Adult Hindgut    520.4 Adult Malpighian Tubules    245 Adult Fat Body    1109.8 Adult Salivary Gland    548.1 Adult Heart    463.9 Adult VirginFemale Spermatheca    955.5 Adult InseminatedFemale Spermatheca    656.2 Adult Ovary    292.4 Adult Testis    120.6 Adult Male Accessory Gland    386.3 Adult Carcass    425.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    332.3   NA  Eye    249.7   NA  Brain    238   266.625  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    173.3   NA  Crop    1060.9   82.4  Midgut    97.5   227.3  Hindgut    520.4   215.4  Malpighian Tubules    245   201.1  Fat Body    1109.8   499.2  Salivary Gland    548.1   NA  Heart    463.9   169.9  Trachea    NA   NA  VirginFemale Spermatheca    955.5   NA  InseminatedFemale Spermatheca    656.2   NA  Ovary    292.4   NA  Testis    120.6   NA  Male Accessory Gland    386.3   235.775  Carcass    425.1 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    30 central nervous system, larvae L3    46 central nervous system, pupae P8    67 head, virgin 1-day female    44 head, virgin 4-day female    54 head, virgin 20-day female    45 head, mated 1-day female    48 head, mated 4-day female    48 head, mated 20-day female    47 head, mated 1-day male    67 head, mated 4-day male    69 head, mated 20-day male    62 salivary gland, larvae L3 wandering    12 salivary gland, white prepupae    26 digestive system, larvae L3 wandering    14 digestive system, 1-day adult    16 digestive system, 4-day adult    19 digestive system, 20-day adult    15 fat body, larvae L3 wandering    12 fat body, white prepupae    28 fat body, pupae P8    25 carcass, larvae L3 wandering    20 carcass, 1-day adult    42 carcass, 4-day adult    46 carcass, 20-day adult    50 ovary, virgin 4-day female    48 ovary, mated 4-day female    50 testis, mated 4-day male    18 accessory gland, mated 4-day male    26 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (30) central nervous system, larvae L3  (46) central nervous system, pupae P8  (67) head, virgin 1-day female  (44) head, virgin 4-day female  (54) head, virgin 20-day female  (45) head, mated 1-day female  (48) head, mated 4-day female  (48) head, mated 20-day female  (47) head, mated 1-day male  (67) head, mated 4-day male  (69) head, mated 20-day male  (62) salivary gland, larvae L3 wandering    12 salivary gland, white prepupae  26 digestive system, larvae L3 wandering    14 digestive system, 1-day adult    16 digestive system, 4-day adult    19 digestive system, 20-day adult    15 fat body, larvae L3 wandering    12 fat body, white prepupae  (28) fat body, pupae P8    25 carcass, larvae L3 wandering    20 carcass, 1-day adult  (42) carcass, 4-day adult  (46) carcass, 20-day adult  (50) ovary, virgin 4-day female  (48) ovary, mated 4-day female  (50) testis, mated 4-day male    18 accessory gland, mated 4-day male  26 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    30 central nervous system, larvae L3    46 central nervous system, pupae P8    67 head, virgin 1-day female    44 head, virgin 4-day female    54 head, virgin 20-day female    45 head, mated 1-day female    48 head, mated 4-day female    48 head, mated 20-day female    47 head, mated 1-day male    67 head, mated 4-day male    69 head, mated 20-day male    62 salivary gland, larvae L3 wandering    12 salivary gland, white prepupae    26 digestive system, larvae L3 wandering    14 digestive system, 1-day adult    16 digestive system, 4-day adult    19 digestive system, 20-day adult    15 fat body, larvae L3 wandering    12 fat body, white prepupae    28 fat body, pupae P8    25 carcass, larvae L3 wandering    20 carcass, 1-day adult    42 carcass, 4-day adult    46 carcass, 20-day adult    50 ovary, virgin 4-day female    48 ovary, mated 4-day female    50 testis, mated 4-day male    18 accessory gland, mated 4-day male    26 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    30 central nervous system, larvae L3    46 central nervous system, pupae P8    67 head, virgin 1-day female    44 head, virgin 4-day female    54 head, virgin 20-day female    45 head, mated 1-day female    48 head, mated 4-day female    48 head, mated 20-day female    47 head, mated 1-day male    67 head, mated 4-day male    69 head, mated 20-day male    62 salivary gland, larvae L3 wandering    12 salivary gland, white prepupae    26 digestive system, larvae L3 wandering    14 digestive system, 1-day adult    16 digestive system, 4-day adult    19 digestive system, 20-day adult    15 fat body, larvae L3 wandering    12 fat body, white prepupae    28 fat body, pupae P8    25 carcass, larvae L3 wandering    20 carcass, 1-day adult    42 carcass, 4-day adult    46 carcass, 20-day adult    50 ovary, virgin 4-day female    48 ovary, mated 4-day female    50 testis, mated 4-day male    18 accessory gland, mated 4-day male    26 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    30 central nervous system, larvae L3    46 central nervous system, pupae P8    67 head, virgin 1-day female    44 head, virgin 4-day female    54 head, virgin 20-day female    45 head, mated 1-day female    48 head, mated 4-day female    48 head, mated 20-day female    47 head, mated 1-day male    67 head, mated 4-day male    69 head, mated 20-day male    62 salivary gland, larvae L3 wandering    12 salivary gland, white prepupae    26 digestive system, larvae L3 wandering    14 digestive system, 1-day adult    16 digestive system, 4-day adult    19 digestive system, 20-day adult    15 fat body, larvae L3 wandering    12 fat body, white prepupae    28 fat body, pupae P8    25 carcass, larvae L3 wandering    20 carcass, 1-day adult    42 carcass, 4-day adult    46 carcass, 20-day adult    50 ovary, virgin 4-day female    48 ovary, mated 4-day female    50 testis, mated 4-day male    18 accessory gland, mated 4-day male    26 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  30 central nervous system, larvae L3  (46) central nervous system, pupae P8  (67) head, virgin 1-day female  (44) head, virgin 4-day female  (54) head, virgin 20-day female  (45) head, mated 1-day female  (48) head, mated 4-day female  (48) head, mated 20-day female  (47) head, mated 1-day male  (67) head, mated 4-day male  (69) head, mated 20-day male  (62) salivary gland, larvae L3 wandering    12 salivary gland, white prepupae  26 digestive system, larvae L3 wandering    14 digestive system, 1-day adult    16 digestive system, 4-day adult    19 digestive system, 20-day adult    15 fat body, larvae L3 wandering    12 fat body, white prepupae  28 fat body, pupae P8    25 carcass, larvae L3 wandering    20 carcass, 1-day adult  (42) carcass, 4-day adult  (46) carcass, 20-day adult  (50) ovary, virgin 4-day female  (48) ovary, mated 4-day female  (50) testis, mated 4-day male    18 accessory gland, mated 4-day male  26 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    30 central nervous system, larvae L3    46 central nervous system, pupae P8    67 head, virgin 1-day female    44 head, virgin 4-day female    54 head, virgin 20-day female    45 head, mated 1-day female    48 head, mated 4-day female    48 head, mated 20-day female    47 head, mated 1-day male    67 head, mated 4-day male    69 head, mated 20-day male    62 salivary gland, larvae L3 wandering    12 salivary gland, white prepupae    26 digestive system, larvae L3 wandering    14 digestive system, 1-day adult    16 digestive system, 4-day adult    19 digestive system, 20-day adult    15 fat body, larvae L3 wandering    12 fat body, white prepupae    28 fat body, pupae P8    25 carcass, larvae L3 wandering    20 carcass, 1-day adult    42 carcass, 4-day adult    46 carcass, 20-day adult    50 ovary, virgin 4-day female    48 ovary, mated 4-day female    50 testis, mated 4-day male    18 accessory gland, mated 4-day male    26 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    30 central nervous system, larvae L3    46 central nervous system, pupae P8    67 head, virgin 1-day female    44 head, virgin 4-day female    54 head, virgin 20-day female    45 head, mated 1-day female    48 head, mated 4-day female    48 head, mated 20-day female    47 head, mated 1-day male    67 head, mated 4-day male    69 head, mated 20-day male    62 salivary gland, larvae L3 wandering    12 salivary gland, white prepupae    26 digestive system, larvae L3 wandering    14 digestive system, 1-day adult    16 digestive system, 4-day adult    19 digestive system, 20-day adult    15 fat body, larvae L3 wandering    12 fat body, white prepupae    28 fat body, pupae P8    25 carcass, larvae L3 wandering    20 carcass, 1-day adult    42 carcass, 4-day adult    46 carcass, 20-day adult    50 ovary, virgin 4-day female    48 ovary, mated 4-day female    50 testis, mated 4-day male    18 accessory gland, mated 4-day male    26 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    44 embryo 02-04hr    47 embryo 04-06hr    27 embryo 06-08hr    31 embryo 08-10hr    35 embryo 10-12hr    37 embryo 12-14hr    38 embryo 14-16hr    34 embryo 16-18hr    39 embryo 18-20hr    30 embryo 20-22hr    33 embryo 22-24hr    39 larva L1    24 larva L2    17 larva L3 12hr old    12 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    21 white prepupae new    21 white prepupae 12hr    19 white prepupae 24hr    21 pupae 2d postWPP    24 pupae 3d postWPP    18 pupae 4d postWPP    14 adult male 01day    30 adult male 05day    33 adult male 30day    29 adult female 01day    26 adult female 05day    36 adult female 30day    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (44) embryo 02-04hr  (47) embryo 04-06hr  (27) embryo 06-08hr  (31) embryo 08-10hr  (35) embryo 10-12hr  (37) embryo 12-14hr  (38) embryo 14-16hr  (34) embryo 16-18hr  (39) embryo 18-20hr  (30) embryo 20-22hr  (33) embryo 22-24hr  (39) larva L1    24 larva L2    17 larva L3 12hr old    12 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    21 white prepupae new    21 white prepupae 12hr    19 white prepupae 24hr    21 pupae 2d postWPP    24 pupae 3d postWPP    18 pupae 4d postWPP    14 adult male 01day  (30) adult male 05day  (33) adult male 30day  (29) adult female 01day  26 adult female 05day  (36) adult female 30day  (37) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    44 embryo 02-04hr    47 embryo 04-06hr    27 embryo 06-08hr    31 embryo 08-10hr    35 embryo 10-12hr    37 embryo 12-14hr    38 embryo 14-16hr    34 embryo 16-18hr    39 embryo 18-20hr    30 embryo 20-22hr    33 embryo 22-24hr    39 larva L1    24 larva L2    17 larva L3 12hr old    12 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    21 white prepupae new    21 white prepupae 12hr    19 white prepupae 24hr    21 pupae 2d postWPP    24 pupae 3d postWPP    18 pupae 4d postWPP    14 adult male 01day    30 adult male 05day    33 adult male 30day    29 adult female 01day    26 adult female 05day    36 adult female 30day    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    44 embryo 02-04hr    47 embryo 04-06hr    27 embryo 06-08hr    31 embryo 08-10hr    35 embryo 10-12hr    37 embryo 12-14hr    38 embryo 14-16hr    34 embryo 16-18hr    39 embryo 18-20hr    30 embryo 20-22hr    33 embryo 22-24hr    39 larva L1    24 larva L2    17 larva L3 12hr old    12 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    21 white prepupae new    21 white prepupae 12hr    19 white prepupae 24hr    21 pupae 2d postWPP    24 pupae 3d postWPP    18 pupae 4d postWPP    14 adult male 01day    30 adult male 05day    33 adult male 30day    29 adult female 01day    26 adult female 05day    36 adult female 30day    37 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    44 embryo 02-04hr    47 embryo 04-06hr    27 embryo 06-08hr    31 embryo 08-10hr    35 embryo 10-12hr    37 embryo 12-14hr    38 embryo 14-16hr    34 embryo 16-18hr    39 embryo 18-20hr    30 embryo 20-22hr    33 embryo 22-24hr    39 larva L1    24 larva L2    17 larva L3 12hr old    12 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    21 white prepupae new    21 white prepupae 12hr    19 white prepupae 24hr    21 pupae 2d postWPP    24 pupae 3d postWPP    18 pupae 4d postWPP    14 adult male 01day    30 adult male 05day    33 adult male 30day    29 adult female 01day    26 adult female 05day    36 adult female 30day    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (44) embryo 02-04hr  (47) embryo 04-06hr  27 embryo 06-08hr  31 embryo 08-10hr  (35) embryo 10-12hr  (37) embryo 12-14hr  (38) embryo 14-16hr  (34) embryo 16-18hr  (39) embryo 18-20hr  30 embryo 20-22hr  (33) embryo 22-24hr  (39) larva L1    24 larva L2    17 larva L3 12hr old    12 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    21 white prepupae new    21 white prepupae 12hr    19 white prepupae 24hr    21 pupae 2d postWPP    24 pupae 3d postWPP    18 pupae 4d postWPP    14 adult male 01day  30 adult male 05day  (33) adult male 30day  29 adult female 01day  26 adult female 05day  (36) adult female 30day  (37) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    44 embryo 02-04hr    47 embryo 04-06hr    27 embryo 06-08hr    31 embryo 08-10hr    35 embryo 10-12hr    37 embryo 12-14hr    38 embryo 14-16hr    34 embryo 16-18hr    39 embryo 18-20hr    30 embryo 20-22hr    33 embryo 22-24hr    39 larva L1    24 larva L2    17 larva L3 12hr old    12 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    21 white prepupae new    21 white prepupae 12hr    19 white prepupae 24hr    21 pupae 2d postWPP    24 pupae 3d postWPP    18 pupae 4d postWPP    14 adult male 01day    30 adult male 05day    33 adult male 30day    29 adult female 01day    26 adult female 05day    36 adult female 30day    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    44 embryo 02-04hr    47 embryo 04-06hr    27 embryo 06-08hr    31 embryo 08-10hr    35 embryo 10-12hr    37 embryo 12-14hr    38 embryo 14-16hr    34 embryo 16-18hr    39 embryo 18-20hr    30 embryo 20-22hr    33 embryo 22-24hr    39 larva L1    24 larva L2    17 larva L3 12hr old    12 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    21 white prepupae new    21 white prepupae 12hr    19 white prepupae 24hr    21 pupae 2d postWPP    24 pupae 3d postWPP    18 pupae 4d postWPP    14 adult male 01day    30 adult male 05day    33 adult male 30day    29 adult female 01day    26 adult female 05day    36 adult female 30day    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    55 Schneider line 2 Sg4    38 embryonic 1182-4H    31 embryonic GM2    30 embryonic Kc167    32 embryonic S1    31 embryonic S3    43 leg disc CME L1    37 wing disc CME-W2    37 wing disc ML-DmD8    27 wing disc ML-DmD9    26 wing disc ML-DmD16-c3    34 wing disc ML-DmD21    25 wing disc ML-DmD32    48 haltere disc ML-DmD17-c3    32 eye-antennal disc ML-DmD11    23 antennal disc ML-DmD20-c5    43 mixed discs ML-DmD4-c1    38 CNS ML-DmBG1-c1    32 CNS ML-DmBG2-c2    37 tumorous blood cells mbn2    45 ovary fGS/OSS    38 ovary OSC    49 ovary OSS    28 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (55) Schneider line 2 Sg4  (38) embryonic 1182-4H  (31) embryonic GM2  (30) embryonic Kc167  (32) embryonic S1  (31) embryonic S3  (43) leg disc CME L1  (37) wing disc CME-W2  (37) wing disc ML-DmD8  (27) wing disc ML-DmD9  26 wing disc ML-DmD16-c3  (34) wing disc ML-DmD21    25 wing disc ML-DmD32  (48) haltere disc ML-DmD17-c3  (32) eye-antennal disc ML-DmD11    23 antennal disc ML-DmD20-c5  (43) mixed discs ML-DmD4-c1  (38) CNS ML-DmBG1-c1  (32) CNS ML-DmBG2-c2  (37) tumorous blood cells mbn2  (45) ovary fGS/OSS  (38) ovary OSC  (49) ovary OSS  (28) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    55 Schneider line 2 Sg4    38 embryonic 1182-4H    31 embryonic GM2    30 embryonic Kc167    32 embryonic S1    31 embryonic S3    43 leg disc CME L1    37 wing disc CME-W2    37 wing disc ML-DmD8    27 wing disc ML-DmD9    26 wing disc ML-DmD16-c3    34 wing disc ML-DmD21    25 wing disc ML-DmD32    48 haltere disc ML-DmD17-c3    32 eye-antennal disc ML-DmD11    23 antennal disc ML-DmD20-c5    43 mixed discs ML-DmD4-c1    38 CNS ML-DmBG1-c1    32 CNS ML-DmBG2-c2    37 tumorous blood cells mbn2    45 ovary fGS/OSS    38 ovary OSC    49 ovary OSS    28 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    55 Schneider line 2 Sg4    38 embryonic 1182-4H    31 embryonic GM2    30 embryonic Kc167    32 embryonic S1    31 embryonic S3    43 leg disc CME L1    37 wing disc CME-W2    37 wing disc ML-DmD8    27 wing disc ML-DmD9    26 wing disc ML-DmD16-c3    34 wing disc ML-DmD21    25 wing disc ML-DmD32    48 haltere disc ML-DmD17-c3    32 eye-antennal disc ML-DmD11    23 antennal disc ML-DmD20-c5    43 mixed discs ML-DmD4-c1    38 CNS ML-DmBG1-c1    32 CNS ML-DmBG2-c2    37 tumorous blood cells mbn2    45 ovary fGS/OSS    38 ovary OSC    49 ovary OSS    28 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    55 Schneider line 2 Sg4    38 embryonic 1182-4H    31 embryonic GM2    30 embryonic Kc167    32 embryonic S1    31 embryonic S3    43 leg disc CME L1    37 wing disc CME-W2    37 wing disc ML-DmD8    27 wing disc ML-DmD9    26 wing disc ML-DmD16-c3    34 wing disc ML-DmD21    25 wing disc ML-DmD32    48 haltere disc ML-DmD17-c3    32 eye-antennal disc ML-DmD11    23 antennal disc ML-DmD20-c5    43 mixed discs ML-DmD4-c1    38 CNS ML-DmBG1-c1    32 CNS ML-DmBG2-c2    37 tumorous blood cells mbn2    45 ovary fGS/OSS    38 ovary OSC    49 ovary OSS    28 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (55) Schneider line 2 Sg4  (38) embryonic 1182-4H  31 embryonic GM2  30 embryonic Kc167  32 embryonic S1  31 embryonic S3  (43) leg disc CME L1  (37) wing disc CME-W2  (37) wing disc ML-DmD8  27 wing disc ML-DmD9  26 wing disc ML-DmD16-c3  (34) wing disc ML-DmD21    25 wing disc ML-DmD32  (48) haltere disc ML-DmD17-c3  32 eye-antennal disc ML-DmD11    23 antennal disc ML-DmD20-c5  (43) mixed discs ML-DmD4-c1  (38) CNS ML-DmBG1-c1  32 CNS ML-DmBG2-c2  (37) tumorous blood cells mbn2  (45) ovary fGS/OSS  (38) ovary OSC  (49) ovary OSS  28 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    55 Schneider line 2 Sg4    38 embryonic 1182-4H    31 embryonic GM2    30 embryonic Kc167    32 embryonic S1    31 embryonic S3    43 leg disc CME L1    37 wing disc CME-W2    37 wing disc ML-DmD8    27 wing disc ML-DmD9    26 wing disc ML-DmD16-c3    34 wing disc ML-DmD21    25 wing disc ML-DmD32    48 haltere disc ML-DmD17-c3    32 eye-antennal disc ML-DmD11    23 antennal disc ML-DmD20-c5    43 mixed discs ML-DmD4-c1    38 CNS ML-DmBG1-c1    32 CNS ML-DmBG2-c2    37 tumorous blood cells mbn2    45 ovary fGS/OSS    38 ovary OSC    49 ovary OSS    28 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    55 Schneider line 2 Sg4    38 embryonic 1182-4H    31 embryonic GM2    30 embryonic Kc167    32 embryonic S1    31 embryonic S3    43 leg disc CME L1    37 wing disc CME-W2    37 wing disc ML-DmD8    27 wing disc ML-DmD9    26 wing disc ML-DmD16-c3    34 wing disc ML-DmD21    25 wing disc ML-DmD32    48 haltere disc ML-DmD17-c3    32 eye-antennal disc ML-DmD11    23 antennal disc ML-DmD20-c5    43 mixed discs ML-DmD4-c1    38 CNS ML-DmBG1-c1    32 CNS ML-DmBG2-c2    37 tumorous blood cells mbn2    45 ovary fGS/OSS    38 ovary OSC    49 ovary OSS    28 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    22 cold shock, 4-day adult    16 heat shock, 4-day adult    24 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    22 Cadmium 100 mM 48 hrs, 4-day adult    47 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    68 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    49 Ethanol 2.5% 3 hrs, larvae L3    39 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    50 Caffeine 25 mg/ml 48 hrs, 4-day adult    27 Paraquat 5 mM 48 hrs, 4-day adult    49 Paraquat 10 mM 48 hrs, 4-day adult    35 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    22 cold shock, 4-day adult    16 heat shock, 4-day adult    24 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    22 Cadmium 100 mM 48 hrs, 4-day adult  (47) Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult  (68) Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult  (49) Ethanol 2.5% 3 hrs, larvae L3  (39) Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (50) Caffeine 25 mg/ml 48 hrs, 4-day adult  (27) Paraquat 5 mM 48 hrs, 4-day adult  (49) Paraquat 10 mM 48 hrs, 4-day adult  (35) Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    22 cold shock, 4-day adult    16 heat shock, 4-day adult    24 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    22 Cadmium 100 mM 48 hrs, 4-day adult    47 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    68 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    49 Ethanol 2.5% 3 hrs, larvae L3    39 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    50 Caffeine 25 mg/ml 48 hrs, 4-day adult    27 Paraquat 5 mM 48 hrs, 4-day adult    49 Paraquat 10 mM 48 hrs, 4-day adult    35 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    22 cold shock, 4-day adult    16 heat shock, 4-day adult    24 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    22 Cadmium 100 mM 48 hrs, 4-day adult    47 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    68 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    49 Ethanol 2.5% 3 hrs, larvae L3    39 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    50 Caffeine 25 mg/ml 48 hrs, 4-day adult    27 Paraquat 5 mM 48 hrs, 4-day adult    49 Paraquat 10 mM 48 hrs, 4-day adult    35 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    11 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    22 cold shock, 4-day adult    16 heat shock, 4-day adult    24 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    22 Cadmium 100 mM 48 hrs, 4-day adult    47 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    68 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    49 Ethanol 2.5% 3 hrs, larvae L3    39 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    50 Caffeine 25 mg/ml 48 hrs, 4-day adult    27 Paraquat 5 mM 48 hrs, 4-day adult    49 Paraquat 10 mM 48 hrs, 4-day adult    35 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    22 cold shock, 4-day adult    16 heat shock, 4-day adult    24 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    22 Cadmium 100 mM 48 hrs, 4-day adult  (47) Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult  (68) Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult  (49) Ethanol 2.5% 3 hrs, larvae L3  (39) Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (50) Caffeine 25 mg/ml 48 hrs, 4-day adult  27 Paraquat 5 mM 48 hrs, 4-day adult  (49) Paraquat 10 mM 48 hrs, 4-day adult  (35) Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    22 cold shock, 4-day adult    16 heat shock, 4-day adult    24 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    22 Cadmium 100 mM 48 hrs, 4-day adult    47 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    68 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    49 Ethanol 2.5% 3 hrs, larvae L3    39 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    50 Caffeine 25 mg/ml 48 hrs, 4-day adult    27 Paraquat 5 mM 48 hrs, 4-day adult    49 Paraquat 10 mM 48 hrs, 4-day adult    35 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    22 cold shock, 4-day adult    16 heat shock, 4-day adult    24 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    22 Cadmium 100 mM 48 hrs, 4-day adult    47 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    68 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    49 Ethanol 2.5% 3 hrs, larvae L3    39 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    50 Caffeine 25 mg/ml 48 hrs, 4-day adult    27 Paraquat 5 mM 48 hrs, 4-day adult    49 Paraquat 10 mM 48 hrs, 4-day adult    35 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_01 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	BDGP expression data • RE25122 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003134 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6593-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4pnr-MD237 Pp1α-96AGD11970 viable Pp1α-96A2 Pp1α-96AEY12810 Pp1α-96AGS11179 viable (with Df(3R)crb87-5) Pp1α-96AGS11179 Sterility Allele fertile Pp1α-96A2 Pp1α-96AEY12810 Phenotype manifest in Allele
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of Pp1α-96A Class Mutagen Stocks Known lesion Pp1α-96A2 loss of function allele Delta2-3 2 Yes Pp1α-96AEY12810 P-element activity 1 -- Pp1α-96AGS11179 1 Yes
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Pp1α-96A Class Mutagen Stocks Known lesion Pp1α-96AGD11970 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Pp1α-96AHMS02154 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Pp1α-96AHMS02477 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Pp1α-96AKK108922 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Pp1α-96AScer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel7357 (Ryder, 2004.4.26) Df(3R)Exel8178 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{UAS-Pp1α-96A.HA} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}Pp1α-96AEY12810 NA P{GSV6}Pp1α-96AGS11179 NA
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
hydrolase activity inferred from electronic annotation with InterPro:IPR004843, InterPro:IPR006186 (FlyBase Curators et al., 2004-) protein serine/threonine phosphatase activity inferred from sequence or structural similarity (Dombradi et al., 1989) non-traceable author statement (Morrison et al., 2000, Swiss-Prot Project Members, 1996.2.1)
Biological Process
CV term Evidence References
protein dephosphorylation inferred from sequence or structural similarity (Dombradi et al., 1989) non-traceable author statement (Morrison et al., 2000, Swiss-Prot Project Members, 1996.2.1)
Cellular Component
CV term Evidence References
protein phosphatase type 1 complex inferred from sequence or structural similarity (Dombradi et al., 1989)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Pp1α-96A - I-2 experimental knowledge based (Guruharsha et al., 2011) Pp1α-96A - sds22 experimental knowledge based (Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Pp1α-96A allele Gene References Pp1α-96AScer\UAS.T:Ivir\HA1 NiPp1 (Parker et al., 2002, Bennett et al., 2003) unspecified Pp1-87B (Kirchner et al., 2007)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 67848 DroID - A comprehensive database of gene and protein interactions. • FBgn0003134 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42922 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • P48461
Orthologs
OrthoDB Orthologs (62) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6SN27R Dipteran inclusive ortholog search EOG6VMFQ3 Insect inclusive ortholog search EOG6XD2MT Arthropod inclusive ortholog search EOG60RXXC Metazoa inclusive ortholog search EOG6DVJF3
Orthologs in Drosophila Species (EOG6SN27R)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Pp1α-96A     Drosophila simulans   Dsim\GD21106 Y   Drosophila sechellia   Dsec\GM26605 Y   Drosophila erecta   Dere\GG11298 Y   Drosophila yakuba   Dyak\GE23493 Y   Drosophila ananassae   Dana\GF20754 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA26434 Y   Drosophila willistoni   Dwil\GK22343 Y   Drosophila virilis   Dvir\GJ23819 Y   Drosophila mojavensis   Dmoj\GI10084 Y   Drosophila grimshawi   Dgri\GH18826 Y
Orthologs in non-Drosophila Dipterans (EOG6VMFQ3)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL009275   Anopheles gambiae Malaria mosquito  Agam\AGAP011166   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ008212
Orthologs in non-Dipteran Insects (EOG6XD2MT)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC409430 Y Apis mellifera Western honey bee  Amel\LOC409804 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG004180 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG001441 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH19817 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH22552 Y Atta cephalotes Leafcutter ant  Acep\ACEP17433 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO16348 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO18880 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL22925 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL12906 Y Linepithema humile Argentine ant  Lhum\LH12603 Y Linepithema humile Argentine ant  Lhum\LH10743 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB14845 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB14481 Y Solenopsis invicta Red fire ant  Sinv\SINV10914 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI004455 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI005202 Y Bombyx mori Silkmoth  Bmor\BGIBMGA008501 Y Pediculus humanus Human body louse  Phum\PHUM570660 Y Tribolium castaneum Red flour beetle  Tcas\GLEAN_15321 Y Tribolium castaneum Red flour beetle  Tcas\GLEAN_08406 Y
Orthologs in non-Insect Arthropods (EOG60RXXC)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\CHS2 Y Daphnia pulex Water flea  Dpux\ZNF3 Y Ixodes scapularis Deer tick  Isca\ISCW012293 Y
Orthologs in non-Arthropod Metazoa (EOG6DVJF3)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\gsp-1 Y Caenorhabditis elegans Nematode  Cele\gsp-2 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_001788gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_008700gn Y Danio rerio Zebrafish  Drer\ppp1caa Y Danio rerio Zebrafish  Drer\ppp1cab Y Danio rerio Zebrafish  Drer\ppp1cb Y Danio rerio Zebrafish  Drer\ppp1cbl Y Danio rerio Zebrafish  Drer\ppp1cc Y Xenopus tropicalis Western clawed frog  Xtro\ppp1ca Y Xenopus tropicalis Western clawed frog  Xtro\ppp1cc Y Xenopus tropicalis Western clawed frog  Xtro\ppp1cb Y Gallus gallus Domestic chicken  Ggal\PPP1CB Y Gallus gallus Domestic chicken  Ggal\PPP1CC Y Mus musculus House mouse  Mmus\Ppp1ca Y Mus musculus House mouse  Mmus\Ppp1cb Y Mus musculus House mouse  Mmus\Ppp1cc Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000042597 Y Rattus norvegicus Norway rat  Rnor\Ppp1cb Y Rattus norvegicus Norway rat  Rnor\Ppp1ca Y Rattus norvegicus Norway rat  Rnor\Ppp1cc Y Homo sapiens Human  Hsap\PPP1CC Y Homo sapiens Human  Hsap\PPP1CA Y
Human Orthologs (2)
Gene OMIM HGNC Hsap\PPP1CC     Hsap\PPP1CA
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD21106 Drosophila sechellia Dsec\GM26605 Drosophila erecta Dere\GG11298 Drosophila yakuba Dyak\GE23493 Drosophila ananassae Dana\GF20754 Drosophila pseudoobscura pseudoobscura Dpse\GA26434 Drosophila willistoni Dwil\GK22343 Drosophila virilis Dvir\GJ23819 Drosophila mojavensis Dmoj\GI10084 Drosophila grimshawi Dgri\GH18826
Stocks & Reagents
Stocks Listed in FlyBase ( 9 )
Bloomington	40906 y1 v1; P{TRiP.HMS02154}attP40 23700 w*; P{UAS-Pp1α-96A.HA}3/TM6B, Tb1 42641 y1 sc* v1; P{TRiP.HMS02477}attP40 20844 y1 w67c23; P{EPgy2}Pp1α-96AEY12810 23698 ry506 e1 Pp1α-96A2/TM6B, P{Ubi-GFP.S65T}PAD2, Tb1 23699 w*; Pp1-87B87Bg-3 e1 Pp1α-96A2/TM6B, Tb1 23697 w*; ru1 h1 st1 ry506 e1 P{GSV6}Pp1α-96AGS11179
VDRC	v105525 P{KK108922}VIE-260B v27673 w1118; P{GD11970}v27673
Genomic Clones ( 2 )
	BACR13M04 BACR47D16 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 173 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD14639
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH04076 GH26330 GM04083 HL01479 LD01065 LD02043 LD03757 LD04158 LD07962 LD08728 LD08848 LD10074 LD22766 RE16094 RE27411 RE29791 RE30108 RE35682 RE38646 RE52305 RE59596 RE60952 RE68820 RE71105 RE72780 RH09056 SD07315 SD13138 SD14020 SD20362 SD22032 SD23970 SD24843 SD24882
Other clones	5897 5966 14500 35536 43312 51508 70331 71211 78931 121040 145112 145309 153993 172894 191111 CK01.20A.B6 CK01.24B.H9 CK01.52D.E8 CK01.79D.E10 CK01.98A.F7 CK01.169A.G6 CK01.169C.G6 CK01.169D.G8 Dmel_dig_016338_0706_3224 Dmel_dig_017903_0667_1072 Dmel_neb_005862_0612_2279 Dmel_neb_006719_0652_2708 Dmel_neb_007810_0581_0546 Dmel_neb_009632_0651_3326 Dmel_neb_013651_0180_3372 EC35115 EC051091 EC051094 EC053350 EC054090 EC055940 EC056216 EC253252 EC253703 EC255889 EC257744 EK000909 EK018730 EK023407 EK063355 EK103959 EK104160 EK116558 EK144107 EK146217 EK159125 EK171640 EK193107 EK198145 EK199138 EK206236 EK207407 EK240961 EK252241 EK273455 EK294044 EP07538 EP08828 EP16232 EP16541 GM03360 IP03107 IP09261 IP09361 IP09461 IP09561 RE25122 RH09055 RP003026121 RP003030935 RP003031260 RP003039301 RP003048934 RP003050447 RP003054071 RP003055580 RP003057384 RP003070803 RP003084327 RP003091531 RP003094941 RP003097512 RP003104072 RP003111976 RP003130608 RP003153030 RP003157923 RP003169730 RP003175131 RP003175250 RP003177908 RP003180100 RP003183187 RP003203116 RP003203952 RP003205878 RP003217512 RP003222539 RP003222909 RP003243712 RP003244862 RP003257797 RP003277318 RP003277439 RP003306615 RP003307865 RP003317955 RP003331099 RP003336358 RP003342854 RP003357760 RP003396745 RP003397332 RP003455759 RP003461445 RP003485431 RP003488664 RP003494622 RP003499545 RP003512619 RP003554183 RP003573309 RP003586199 RP003599651 RP003603221 RP003615392 RP003621681 RP003626176 RP003628663 RP003637443 RP003637486 RP003639854 UUGC0835
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0003134 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42922
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Pp1α-96A CG6593 (Kodira, 1999.11)
Source for database merge of
Additional comments
Other Comments
	Isolated from a 0-4 hour embryonic cDNA library, using a Pp1-87B fragment as a probe. (Dombradi et al., 1990) Pp1α-96A has been cloned and sequenced. (Dombradi et al., 1990)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079760 NM_001275990 RefSeq (Proteins) • NP_524484 NP_001262919 DDBJ / EMBL / GenBank • AAF56306 AAV36995 AGB96299 BI231940 BT016110 CAA39820 CL943541 X56438 Entrez Gene - A searchable database of RefSeq genes. • 42922 UniProtKB/Swiss-Prot • P48461
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Metallophosphoesterase domain (IPR004843) Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase (IPR006186) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RE25122
Linkouts
	BioGRID - A database of protein and genetic interactions • 67848 DroID - A comprehensive database of gene and protein interactions. • FBgn0003134 DRSC - Results from RNAi screens. • FBgn0003134 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003134 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6593-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0003134 FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways • 98694 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42922 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42922 modMine - Data generated by the modENCODE project. • FBgn0003134 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • P48461
Synonyms & Secondary IDs ( 17 )
Reported As
Symbol Synonym	96A (Fang et al., 2007, Su et al., 2011) CG6593 (Bhutkar et al., 2008, Morrison et al., 2000, Keleman et al., 2009.8.5, Wheeler et al., 2004, Ni et al., 2010.12.1) DmPp1-96A (Cohen, 2005) PP1 (Lioultcheva et al., 2002, Alphey et al., 2000, Helps et al., 1998, Fang et al., 2007, Tan et al., 2007) Pp1-96A (Bjorklund et al., 2006, de Carvalho et al., 2001, Ranz et al., 2001, Ranz et al., 1999, Ruiz et al., 1997, Wheeler et al., 2004) PP1 96A (Morrison et al., 2000, Armstrong et al., 1998, Cohen, 1997, Dombradi et al., 1993, Chen et al., 1992) Pp1alpha-96A (Bhutkar et al., 2008, Giot et al., 2003, Kirchner, 2007.7.19, Wang et al., 2004, Kong et al., 2010, Guruharsha et al., 2011) PP1c (Rudenko et al., 2003, Bennett and Alphey, 2002, Rudenko et al., 2003) PP1c 96A (Luo et al., 2007) PP1α96A (Parker et al., 2002, Bennett et al., 2003, Bennett et al., 1999, Alphey et al., 1998, Dombradi et al., 1990, Kirchner et al., 2007, Rudenko et al., 2003, Kirchner et al., 2008, Bennett et al., 2006, Guruharsha et al., 2011) Pp1α-96A (Finan et al., 2011, Swanhart et al., 2007) PP1 α96a (Grusche et al., 2009) pp1α96A (Cronin et al., 2009) PP1α1 (Cohen et al., 1990) unnamed (Dombradi et al., 1989)
Name Synonym	protein phosphatase 1 (Fang et al., 2007) Protein phosphatase 1α at 96A
Secondary FlyBase IDs
References ( 68 )
Generate a list of	All references relating to this gene ( 68 )
List References by type	Research paper  ( 33 ) Supplementary material  ( 8 ) Review  ( 5 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 7 ) FlyBase analysis  ( 1 ) Curated genome annotation  ( 3 ) Protein sequence record  ( 1 ) Website  ( 1 )
Recent research papers ( 6 )
	Díaz-Castillo and Ranz, 2012, Mol. Biol. Evol. 29(9): 2105--2108 Nuclear chromosome dynamics in the Drosophila male germ line contribute to the nonrandom genomic distribution of retrogenes. [FBrf0219274] Shaukat et al., 2012, PLoS ONE 7(10): e47447 A screen for selective killing of cells with chromosomal instability induced by a spindle checkpoint defect. [FBrf0219770] Finan et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(14): 5566--5571 From the Cover: Proteomics approach to study the functions of Drosophila myosin VI through identification of multiple cargo-binding proteins. [FBrf0213355] Guruharsha et al., 2011, Cell 147(3): 690--703 A Protein Complex Network of Drosophila melanogaster. [FBrf0216491] Horn et al., 2011, Nat. Methods 8(4): 341--346 Mapping of signaling networks through synthetic genetic interaction analysis by RNAi. [FBrf0213352] Su et al., 2011, Sci. Signal. 4(180): ra43 Sequential phosphorylation of smoothened transduces graded hedgehog signaling. [FBrf0216577] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...