FB2020_06, released Dec 22, 2020

Gene: Dmel\Pp1α-96A

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General Information
Symbol
Dmel\Pp1α-96A
Species
D. melanogaster
Name
Protein phosphatase 1α at 96A
Annotation Symbol
CG6593
Feature Type
protein_coding_gene
FlyBase ID
FBgn0003134
Gene Model Status
Current
Stock Availability
14 publicly available
Gene Snapshot
Protein phosphatase 1α at 96A (Pp1α-96A) encodes a phosphatase involved in the regulation of Hedgehog and Wnt signaling pathways. [Date last reviewed: 2019-09-12]
Other Summaries
Also Known As

PP1α96A, Pp1-96A, PP1, PP1 96A, PP1c

Key Links
Genomic Location
Cytogenetic map
96A5-96A5
Sequence location
3R:24,518,270..24,522,331 [+]
Recombination map

3-85

RefSeq locus
NT_033777 REGION:24518270..24522331
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (10 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables protein serine/threonine phosphatase activity
inferred from biological aspect of ancestor with PANTHER:PTN000185233
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence or structural similarity
(Dombradi et al., 1989)
Biological Process (6 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
involved_in defense response to Gram-negative bacterium
inferred from high throughput mutant phenotype
(Cronin et al., 2009)
involved_in negative regulation of smoothened signaling pathway
inferred from genetic interaction with FLYBASE:NiPp1; FB:FBgn0026402
(Su et al., 2011)
involved_in positive regulation of canonical Wnt signaling pathway
inferred from genetic interaction with FLYBASE:flw; FB:FBgn0000711, FLYBASE:Pp1-87B; FB:FBgn0004103
(Luo et al., 2007)
involved_in positive regulation of innate immune response
inferred from high throughput mutant phenotype
(Cronin et al., 2009)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in beta-catenin destruction complex disassembly
inferred from sequence or structural similarity with UniProtKB:P62139
(Luo et al., 2007)
involved_in protein dephosphorylation
inferred from sequence or structural similarity
(Dombradi et al., 1989)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in cytoplasm
inferred from high throughput direct assay
(Sarov et al., 2016)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN000185233
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000185231
(assigned by GO_Central )
(Gaudet et al., 2011)
part_of protein phosphatase type 1 complex
inferred from sequence or structural similarity
(Dombradi et al., 1989)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
Belongs to the PPP phosphatase family. PP-1 subfamily. (P48461)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
PPP FAMILY PROTEIN SERINE/THREONINE PHOSPHATASES -
The Phosphoprotein Phosphatase (PPP) family members are serine/threonine phosphatases. They often function in association with regulatory subunits. (Adapted from PMID:11230548 and PMID:19879837).
Pathway (FlyBase)
Positive Regulators of Wnt-TCF Signaling Pathway -
Positive regulators of Wnt-TCF (canonical Wnt) signaling up-regulate the pathway, resulting in the enhancement of transcriptional regulation mediated by β-catenin (arm).
Negative Regulators of Hedgehog Signaling Pathway -
Negative regulators of hedgehog signaling down-regulate the pathway, resulting in the repression of transcription of hh-responsive genes.
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
Pp1: Protein phosphatase 1
Encodes a protein phosphatase 1 catalytic subunit that shows a high degree of similarity to rabbit protein phosphatase 1α in its enzymatic and physiochemical characteristics and has a predicted protein sequence that is 92% identical to that of rabbit PP-1α.
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Pp1α-96A for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.47

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Pp1α-96A-RA
FBtr0084642
NM_079760
2221
327
Pp1α-96A-RB
FBtr0334334
NM_001275990
3210
327
Additional Transcript Data and Comments
Reported size (kB)

2.3 (northern blot)

(Dombradi et al., 1990)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Pp1α-96A-PA
FBpp0084026
37.4
327
6.64
NP_524484
AAF56306
Pp1α-96A-PB
FBpp0306442
37.4
327
6.64
NP_001262919
AGB96299
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

327 aa isoforms: Pp1α-96A-PA, Pp1α-96A-PB
Additional Polypeptide Data and Comments
Reported size (kDa)

327 (aa); 37.3 (kD predicted)

(Dombradi et al., 1990)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts with Nop17l.

(UniProt, P48461)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Pp1α-96A using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 16
organism | ubiquitous
(Fisher et al., 2012)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
(Dombradi et al., 1990)
adult stage
(Dombradi et al., 1990)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytoplasm
inferred from high throughput direct assay
(Sarov et al., 2016)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Pp1α-96A in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 6 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Pp1α-96A
Transgenic constructs containing regulatory region of Pp1α-96A
Deletions and Duplications ( 2 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (14)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\PPP1CC
12 of 15
Yes
No
2  
Hsap\PPP1CA
11 of 15
No
No
1  
Hsap\PPP1CB
4 of 15
No
No
Hsap\PPEF1
1 of 15
No
No
Hsap\PPEF2
1 of 15
No
No
Hsap\PPP2CA
1 of 15
No
No
Hsap\PPP2CB
1 of 15
No
No
Hsap\PPP3CA
1 of 15
No
No
2  
Hsap\PPP3CB
1 of 15
No
No
Hsap\PPP3CC
1 of 15
No
No
Hsap\PPP4C
1 of 15
No
No
Hsap\PPP5C
1 of 15
No
No
Hsap\PPP5D1
1 of 15
No
Yes
Hsap\PPP6C
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (14)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Ppp1ca
10 of 15
Yes
No
Mmus\Ppp1ccb
8 of 15
No
No
Mmus\Ppp1cc
6 of 15
No
No
Mmus\Ppp1cb
4 of 15
No
No
Mmus\Ppef1
1 of 15
No
No
Mmus\Ppef2
1 of 15
No
No
Mmus\Ppp2ca
1 of 15
No
No
Mmus\Ppp2cb
1 of 15
No
No
Mmus\Ppp3ca
1 of 15
No
No
Mmus\Ppp3cb
1 of 15
No
No
Mmus\Ppp3cc
1 of 15
No
No
Mmus\Ppp4c
1 of 15
No
No
Mmus\Ppp5c
1 of 15
No
No
Mmus\Ppp6c
1 of 15
No
No
Rattus norvegicus (Norway rat) (12)
Rnor\Ppp1cc
11 of 13
Yes
No
Rnor\Ppp1ca
9 of 13
No
No
Rnor\Ppp1cb
4 of 13
No
No
Rnor\LOC100363225
1 of 13
No
Yes
Rnor\Ppef1
1 of 13
No
No
Rnor\Ppp2ca
1 of 13
No
No
Rnor\Ppp2cb
1 of 13
No
No
Rnor\Ppp3ca
1 of 13
No
No
Rnor\Ppp3cc
1 of 13
No
No
Rnor\Ppp4c
1 of 13
No
No
Rnor\Ppp5c
1 of 13
No
No
Rnor\Ppp6c
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (12)
Xtro\ppp1cc
8 of 12
Yes
No
Xtro\ppp1ca
5 of 12
No
Yes
Xtro\ppp1cb
3 of 12
No
No
Xtro\ppef1
1 of 12
No
No
Xtro\ppp2ca
1 of 12
No
No
Xtro\ppp2cb
1 of 12
No
No
Xtro\ppp3ca
1 of 12
No
No
Xtro\ppp3cb
1 of 12
No
No
Xtro\ppp3cc
1 of 12
No
No
Xtro\ppp4c
1 of 12
No
No
Xtro\ppp5c
1 of 12
No
No
Xtro\ppp6c
1 of 12
No
No
Danio rerio (Zebrafish) (16)
Drer\ppp1caa
11 of 15
Yes
No
Drer\ppp1cc
11 of 15
Yes
No
Drer\ppp1cab
9 of 15
No
No
Drer\ppp1cb
4 of 15
No
No
Drer\ppp1cbl
3 of 15
No
No
Drer\ppef1
1 of 15
No
No
Drer\ppp2ca
1 of 15
No
No
Drer\ppp2cb
1 of 15
No
No
Drer\ppp3ca
1 of 15
No
No
Drer\ppp3cca
1 of 15
No
No
Drer\ppp3ccb
1 of 15
No
No
Drer\ppp4ca
1 of 15
No
No
Drer\ppp4cb
1 of 15
No
No
Drer\ppp5c
1 of 15
No
No
Drer\ppp6c
1 of 15
No
No
Drer\zgc:56064
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (45)
Cele\gsp-2
10 of 15
Yes
No
Cele\C09H5.7
4 of 15
No
Yes
Cele\F25B3.4
4 of 15
No
No
Cele\gsp-1
4 of 15
No
No
Cele\gsp-3
4 of 15
No
Yes
Cele\gsp-4
4 of 15
No
Yes
Cele\pph-1
4 of 15
No
No
Cele\T16G12.7
4 of 15
No
Yes
Cele\ZK354.9
4 of 15
No
No
Cele\C06A1.3
3 of 15
No
No
Cele\C23G10.1
3 of 15
No
No
Cele\C25A6.1
3 of 15
No
No
Cele\C30A5.4
3 of 15
No
No
Cele\C47A4.3
3 of 15
No
No
Cele\F52H3.6
3 of 15
No
No
Cele\F58G1.3
3 of 15
No
No
Cele\R13A5.11
3 of 15
No
No
Cele\ZK938.1
3 of 15
No
No
Cele\C24H11.1
2 of 15
No
No
Cele\C24H11.2
2 of 15
No
No
Cele\C27B7.6
2 of 15
No
No
Cele\C34D4.2
2 of 15
No
No
Cele\F20D6.6
2 of 15
No
Yes
Cele\F22D6.9
2 of 15
No
No
Cele\F23B12.1
2 of 15
No
No
Cele\F26B1.5
2 of 15
No
No
Cele\F42G8.8
2 of 15
No
No
Cele\F44B9.9
2 of 15
No
No
Cele\F49E11.7
2 of 15
No
No
Cele\R03D7.8
2 of 15
No
Yes
Cele\R08A2.2
2 of 15
No
No
Cele\R08C7.8
2 of 15
No
No
Cele\T25B9.2
2 of 15
No
No
Cele\W03D8.2
2 of 15
No
No
Cele\Y69E1A.4
2 of 15
No
No
Cele\Y71G12B.30
2 of 15
No
No
Cele\ZC477.2
2 of 15
No
No
Cele\pef-1
1 of 15
No
No
Cele\pph-4.1
1 of 15
No
No
Cele\pph-4.2
1 of 15
No
No
Cele\pph-5
1 of 15
No
No
Cele\pph-6
1 of 15
No
No
Cele\tax-6
1 of 15
No
No
Cele\Y40H4A.2
1 of 15
No
No
Cele\ZC477.10
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (9)
Atha\TOPP4
8 of 9
Yes
Yes
Atha\TOPP3
7 of 9
No
Yes
Atha\TOPP2
6 of 9
No
Yes
Atha\TOPP1
5 of 9
No
Yes
Atha\TOPP5
5 of 9
No
Yes
Atha\TOPP7
5 of 9
No
Yes
Atha\TOPP6
4 of 9
No
Yes
Atha\TOPP8
2 of 9
No
Yes
Atha\TOPP9
2 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (13)
Scer\GLC7
11 of 15
Yes
Yes
Scer\PPZ1
3 of 15
No
No
Scer\PPQ1
2 of 15
No
No
Scer\PPZ2
2 of 15
No
No
Scer\CMP2
1 of 15
No
No
Scer\CNA1
1 of 15
No
No
Scer\PPG1
1 of 15
No
No
Scer\PPH3
1 of 15
No
No
Scer\PPH21
1 of 15
No
No
Scer\PPH22
1 of 15
No
No
Scer\PPT1
1 of 15
No
No
Scer\SIT4
1 of 15
No
No
Scer\YNL217W
1 of 15
No
Yes
Schizosaccharomyces pombe (Fission yeast) (3)
Spom\dis2
8 of 12
Yes
No
Spom\sds21
4 of 12
No
Yes
Spom\pzh1
1 of 12
No
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190B26 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila simulans
Dsim\GD21106
Drosophila sechellia
Dsec\GM26605
Drosophila erecta
Dere\GG11298
Drosophila yakuba
Dyak\GE23493
Drosophila ananassae
Dana\GF20754
Drosophila pseudoobscura pseudoobscura
Dpse\GA26434
Drosophila willistoni
Dwil\GK22343
Drosophila virilis
Dvir\GJ23819
Drosophila mojavensis
Dmoj\GI10084
Drosophila grimshawi
Dgri\GH18826
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915079C )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17024684
Musca domestica
House fly
Mdoa\17012886
Musca domestica
House fly
Mdoa\17012639
Glossina morsitans
Tsetse fly
Gmor\GMOY011925
Glossina morsitans
Tsetse fly
Gmor\GMOY010082
Glossina morsitans
Tsetse fly
Gmor\GMOY011455
Glossina morsitans
Tsetse fly
Gmor\GMOY008905
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_11001
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_04000
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_12430
Mayetiola destructor
Hessian fly
Mdes\Mdes001829
Mayetiola destructor
Hessian fly
Mdes\Mdes008908
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL009275
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL013181
Anopheles darlingi
American malaria mosquito
Adar\ADAC003425
Anopheles darlingi
American malaria mosquito
Adar\ADAC009028
Anopheles gambiae
Malaria mosquito
Agam\AGAP011166
Anopheles gambiae
Malaria mosquito
Agam\AGAP003114
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ001987
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ008212
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W07JN )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA008501
Danaus plexippus
Monarch butterfly
Dple\DPOGS206670-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL012302
Apis florea
Little honeybee
Aflo\2417179862
Apis florea
Little honeybee
Aflo\2251559860
Apis mellifera
Western honey bee
Amel\LOC409430
Apis mellifera
Western honey bee
Amel\LOC409804
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP22022
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP20446
Bombus terrestris
Buff-tailed bumblebee
Bter\15210649
Bombus terrestris
Buff-tailed bumblebee
Bter\15203407
Linepithema humile
Argentine ant
Lhum\LH12603
Linepithema humile
Argentine ant
Lhum\LH10743
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000227
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG004180
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG001441
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_08326
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_15321
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_08406
Pediculus humanus
Human body louse
Phum\PHUM570660
Rhodnius prolixus
Kissing bug
Rpro\RPRC000214
Rhodnius prolixus
Kissing bug
Rpro\RPRC002352
Cimex lectularius
Bed bug
Clec\CLEC011563
Cimex lectularius
Bed bug
Clec\CLEC006871
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI005202
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI004455
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_03910
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_12258
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X07EY )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR013031
Strigamia maritima
European centipede
Smar\SMAR011276
Ixodes scapularis
Black-legged tick
Isca\ISCW012293
Stegodyphus mimosarum
African social velvet spider
Smim\KFM70178.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM77822.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur15g03360
Tetranychus urticae
Two-spotted spider mite
Turt\tetur04g05120
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_194510
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_231787
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0EKF )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Ppp1cb
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Pp1L
Ciona intestinalis
Vase tunicate
Cint\LOC100187079
Ciona intestinalis
Vase tunicate
Cint\LOC100178587
Gallus gallus
Domestic chicken
Ggal\PPP1CB
Gallus gallus
Domestic chicken
Ggal\PPP1CC
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (18)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Pp1-87B
9 of 10
flw
8 of 10
Pp1-13C
8 of 10
Pp1-Y2
6 of 10
Pp1-Y1
5 of 10
PpD5
5 of 10
PpD6
5 of 10
PpN58A
5 of 10
PpY-55A
5 of 10
CanA1
2 of 10
CanA-14F
2 of 10
CG11597
2 of 10
mts
2 of 10
Pp2B-14D
2 of 10
Pp4-19C
2 of 10
PpD3
2 of 10
PpV
2 of 10
rdgC
2 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    PPP1CC; protein phosphatase 1 catalytic subunit gamma
    12 of 15
    176914
         
        PPP1CA; protein phosphatase 1 catalytic subunit alpha
        11 of 15
        176875
             
            PPP1CB; protein phosphatase 1 catalytic subunit beta
            4 of 15
            600590
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            esyN Network Diagram
            Show neighbor-neighbor interactions:
            Select Layout:
            Legend:
            Protein
            RNA
            Selected Interactor(s)
            Interactions Browser
            View in Interactions Browser
            Please see the Physical Interaction reports below for full details
            protein-protein
            Physical Interaction
            Assay
            References
            Pp1α-96A - ASPP
            anti tag coimmunoprecipitation, anti tag western blot
            (Bertran et al., 2019)
            Pp1α-96A - CG31244
            two hybrid
            (Bennett et al., 2006)
            Pp1α-96A - CG31457
            two hybrid
            (Bennett et al., 2006)
            Pp1α-96A - CG42748
            two hybrid
            (Bennett et al., 2006)
            Pp1α-96A - CG7029
            two hybrid
            (Bennett et al., 2006)
            Pp1α-96A - CG9933
            two hybrid
            (Bennett et al., 2006)
            Pp1α-96A - Ccdc85
            anti tag coimmunoprecipitation, anti tag western blot
            (Bertran et al., 2019)
            Pp1α-96A - Gbs-70E
            two hybrid
            (Kerekes et al., 2014)
            Pp1α-96A - Gbs-76A
            two hybrid
            (Bennett et al., 2006)
            Pp1α-96A - I-2
            two hybrid, experimental knowledge based
            (Guruharsha et al., 2011, Bennett et al., 2006)
            Pp1α-96A - I-3
            two hybrid
            (Bennett et al., 2006)
            Pp1α-96A - NiPp1
            two hybrid
            (Kirchner et al., 2008, Bennett et al., 2006)
            Pp1α-96A - Nop17l
            anti tag coimmunoprecipitation, anti tag western blot, two hybrid
            (Bennett et al., 2006)
            Pp1α-96A - PNUTS
            two hybrid
            (Ciurciu et al., 2013, Bennett et al., 2006)
            Pp1α-96A - PPP1R15
            two hybrid
            (Bennett et al., 2006)
            Pp1α-96A - Ppi1
            two hybrid
            (Bennett et al., 2006)
            Pp1α-96A - RASSF8
            anti tag coimmunoprecipitation, anti tag western blot
            (Bertran et al., 2019)
            Pp1α-96A - REPTOR
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Tiebe et al., 2015)
            Pp1α-96A - Sara
            two hybrid
            (Bennett et al., 2006, Bennett and Alphey, 2002)
            Pp1α-96A - Spindly
            two hybrid
            (Bennett et al., 2006)
            Pp1α-96A - ZAP3
            two hybrid
            (Bennett et al., 2006)
            Pp1α-96A - Zasp66
            two hybrid
            (Bennett et al., 2006)
            Pp1α-96A - corolla
            two hybrid
            (Bennett et al., 2006)
            Pp1α-96A - ec
            two hybrid
            (Bennett et al., 2006)
            Pp1α-96A - mars
            two hybrid, anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Hayward and Wakefield, 2014, Bennett et al., 2006)
            Pp1α-96A - neb
            two hybrid
            (Bennett et al., 2006)
            Pp1α-96A - pico
            two hybrid
            (Bennett et al., 2006)
            Pp1α-96A - sds22
            experimental knowledge based, anti tag coimmunoprecipitation, anti tag western blot
            (Guruharsha et al., 2011, Grusche et al., 2009)
            Pp1α-96A - smo
            anti tag coimmunoprecipitation, western blot
            (Su et al., 2011)
            Pp1α-96A - tim
            anti tag coimmunoprecipitation, anti tag western blot
            (Fang et al., 2007)
            Pp1α-96A - trx
            two hybrid
            (Bennett et al., 2006)
            Pp1α-96A - uri
            two hybrid
            (Kirchner et al., 2008)
            Summary of Genetic Interactions
            esyN Network Diagram
            esyN Network Key:
            Suppression
            Enhancement
            View in Interactions Browser
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Pp1α-96A|flw
            suppressible
            zip
            (Kirchner et al., 2007)
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            NiPp1
            suppressible
            Pp1α-96A
            (Parker et al., 2002)
            Pp1-87B
            suppressible
            Pp1α-96A
            (Kirchner et al., 2007)
            External Data
            Subunit Structure (UniProtKB)
            Interacts with Nop17l.
            (UniProt, P48461 )
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
            MIST (genetic) - An integrated Molecular Interaction Database
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Signaling Pathways (FlyBase)
            Positive Regulators of Wnt-TCF Signaling Pathway -
            Positive regulators of Wnt-TCF (canonical Wnt) signaling up-regulate the pathway, resulting in the enhancement of transcriptional regulation mediated by β-catenin (arm).
            Negative Regulators of Hedgehog Signaling Pathway -
            Negative regulators of hedgehog signaling down-regulate the pathway, resulting in the repression of transcription of hh-responsive genes.
            Metabolic Pathways
            External Data
            Linkouts
            KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            3R
            Recombination map

            3-85

            Cytogenetic map
            96A5-96A5
            Sequence location
            3R:24,518,270..24,522,331 [+]
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            96A5-96A5
            Limits computationally determined from genome sequence between P{PZ}crb07207&P{PZ}BRWD305842 and P{EP}CycB3EP3127
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            96A2-96A5
            (determined by in situ hybridisation)
            (Ranz et al., 1999, Dombradi et al., 1990)
            Experimentally Determined Recombination Data
            Location

            3-85

            (FlyBase, 2016)

            3-83.8

            (Comeron et al., 2012)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (14)
            Genomic Clones (12)
             

            Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

            cDNA Clones (145)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
            Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
              Other clones
              RNAi and Array Information
              Linkouts
              DRSC - Results frm RNAi screens
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              Antibody Information
              Laboratory Generated Antibodies
               
              Commercially Available Antibodies
               
              Other Information
              Relationship to Other Genes
              Source for database identify of

              Source for identity of: Pp1α-96A CG6593

              (Kodira, 1999.11)
              Source for database merge of
              Additional comments
              Other Comments

              Isolated from a 0-4 hour embryonic cDNA library, using a Pp1-87B fragment as a probe.

              (Dombradi et al., 1990)

              Pp1α-96A has been cloned and sequenced.

              (Dombradi et al., 1990)
              Origin and Etymology
              Discoverer
              Etymology
              Identification
              External Crossreferences and Linkouts ( 42 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
              Other crossreferences
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              Flygut - An atlas of the Drosophila adult midgut
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              modMine - A data warehouse for the modENCODE project
              SignaLink - A signaling pathway resource with multi-layered regulatory networks.
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              FLIGHT - Cell culture data for RNAi and other high-throughput technologies
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              FlyMine - An integrated database for Drosophila genomics
              InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
              KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
              MIST (genetic) - An integrated Molecular Interaction Database
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              Synonyms and Secondary IDs (21)
              Reported As
              Symbol Synonym
              96A
              (Su et al., 2011, Fang et al., 2007)
              CG6593
              (Hosono et al., 2015, Cui et al., 2013, Schertel et al., 2013, Müller et al., 2010, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Bhutkar et al., 2008, Wheeler et al., 2004, Morrison et al., 2000)
              DmPp1-96A
              (Cohen et al., 2005)
              PP1
              (Sehgal, 2008, Fang et al., 2007, Tan et al., 2007, Lioultcheva et al., 2002, Alphey et al., 2000, Helps et al., 1998)
              PP1 96A
              (Morrison et al., 2000, Armstrong et al., 1998, Cohen, 1997, Dombradi et al., 1993, Chen et al., 1992)
              PP1 α96a
              (Grusche et al., 2009)
              PP1A-96A
              (Hayward and Wakefield, 2014)
              PP1c
              (Rudenko et al., 2003, Rudenko et al., 2003, Bennett and Alphey, 2002, Bennett and Alphey, 2002)
              PP1c 96A
              (Luo et al., 2007)
              PP1α
              (Barik, 2004)
              PP1α-96A
              (Xue et al., 2019, Branco-Santos et al., 2017)
              PP1α96A
              (Bertran et al., 2019, Zhang et al., 2019, Ciurciu et al., 2013, Guruharsha et al., 2011, Kirchner et al., 2008, Kirchner et al., 2007, Bennett et al., 2006, Bennett et al., 2003, Rudenko et al., 2003, Parker et al., 2002, Bennett et al., 1999, Alphey et al., 1998, Dombradi et al., 1990)
              PP1α1
              (Cohen et al., 1990)
              Pp1-96A
              (Kerekes et al., 2014, Bjorklund et al., 2006, Wheeler et al., 2004, de Carvalho et al., 2001, Ranz et al., 2001, Ranz et al., 1999, Ruiz et al., 1997)
              Pp1alpha-96A
              (Deneke et al., 2019, Brewer-Jensen et al., 2016, Sarov et al., 2016, Sopko et al., 2014, Cui et al., 2013, Kwon et al., 2013, Schertel et al., 2013, Friedman et al., 2011, Guruharsha et al., 2011, Kong et al., 2010, Kong et al., 2010, Müller et al., 2010, Bhutkar et al., 2008, Kirchner, 2007.7.19, Wang et al., 2004, Giot et al., 2003)
              Pp1α-96A
              (Ashton-Beaucage and Therrien, 2017, Agrawal and Hardin, 2016, Finan et al., 2011, Swanhart et al., 2007)
              pp1α-96A
              (Moreira et al., 2019)
              pp1α96A
              (Vonhoff and Keshishian, 2017, Cronin et al., 2009)
              Name Synonyms
              Protein phosphatase 1α at 96A
              protein phosphatase 1
              (Fang et al., 2007)
              protein phosphatase 1α at 96A
              (Tiebe et al., 2015)
              Secondary FlyBase IDs
                Datasets (0)
                Study focus (0)
                Experimental Role
                Project
                Project Type
                Title
                References (113)