FlyBase Gene Report: Dmel\Ppn

General Information

Symbol

Dmel\Ppn

Species

D. melanogaster

Name

Papilin

Annotation Symbol

CG33103

Feature Type

protein_coding_gene

FlyBase ID

FBgn0003137

Gene Model Status

Current

Stock Availability

6 publicly available

Gene Summary

Essential extracellular matrix (ECM) protein that influences cell rearrangements. May act by modulating metalloproteinases action during organogenesis. Able to non-competitively inhibit procollagen N-proteinase, an ADAMTS metalloproteinase. (UniProt, Q868Z9)

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All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

lacunin

Key Links

Genomic Location

Cytogenetic map

98D3-98D4

Sequence location

3R:28,520,665..28,540,324 [-]

Recombination map

3-96

RefSeq locus

NT_033777 REGION:28520665..28540324

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

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Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (7 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables extracellular matrix structural constituent

inferred from mutant phenotype

(assigned by UniProt )

(Kramerova et al., 2000)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables metalloendopeptidase activity

inferred from biological aspect of ancestor with PANTHER:PTN000347317

(assigned by GO_Central )

(Gaudet et al., 2011)

enables serine-type endopeptidase inhibitor activity

inferred from electronic annotation with InterPro:IPR002223

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Biological Process (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in extracellular matrix organization

inferred from mutant phenotype

(assigned by UniProt )

(Kramerova et al., 2000)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in extracellular matrix organization

inferred from biological aspect of ancestor with PANTHER:PTN000347317

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in basement membrane

inferred from direct assay

(Campbell et al., 1987)

inferred from direct assay

(assigned by UniProt )

(Kramerova et al., 2000)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in extracellular matrix

inferred from biological aspect of ancestor with PANTHER:PTN000347317

(assigned by GO_Central )

(Gaudet et al., 2011)

located_in extracellular region

inferred from electronic annotation with InterPro:IPR008197

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Gene Group (FlyBase)

ADAMTS LIKE

Protein Family (UniProt)

Belongs to the papilin family. (Q868Z9)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

ADAMTS LIKE -: ADAMTS-like proteins contain ADAMTS ancillary domains but they lack the catalytic domain and therefore lack proteolytic activity. ADAMTS-like proteins appear to have regulatory roles in the extracellular matrix, perhaps regulating ADAMTS proteins. (Adapted from PMID:19734141.)

Protein Function (UniProtKB)

(UniProt, Q868Z9)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Ppn for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.48

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Ppn-RC

FBtr0300337

NM_001170289

7372

2174

Ppn-RE

FBtr0301837

NM_176575

9544

2898

Ppn-RF

FBtr0301838

NM_176574

9178

2776

Ppn-RG

FBtr0301839

NM_001170290

9373

2841

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Ppn-PC

FBpp0289566

231.8

2174

4.10

NP_001163760

ACZ95054

Ppn-PE

FBpp0291051

313.0

2898

4.19

NP_788752

AAF56795

Ppn-PF

FBpp0291052

299.5

2776

4.18

NP_788751

AAF56794

Ppn-PG

FBpp0291053

306.6

2841

4.17

NP_001163761

ACZ95055

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Homooligomer; disulfide-linked.

(UniProt, Q868Z9)

Post Translational Modification

N-glycosylated.

Sulfated.

(UniProt, Q868Z9)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ppn using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Ppn_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 8

cephalic furrow

Comment: probe does not distinguish isoforms

(Kramerova et al., 2003)

ventral furrow

Comment: probe does not distinguish isoforms

(Kramerova et al., 2003)

amnioproctodeal invagination

Comment: probe does not distinguish isoforms

(Kramerova et al., 2003)

embryonic stage 10

mesoderm | segmentally repeated

Comment: probe does not distinguish isoforms

(Kramerova et al., 2003)

embryonic stage 12 -- 14

hemocyte

Comment: NOT Ppn-RE

(Kramerova et al., 2003)

embryonic stage 14 -- 15

dorsal vessel primordium