A Database of Drosophila Genes & Genomes

FB2012_01, released January 20th, 2012
 

Gene Dmel\Ppn

General Information
SymbolDmel\PpnSpeciesD. melanogaster
NamePapilinAnnotation symbolCG33103
Feature typeprotein_coding_geneFlyBase IDFBgn0003137
Gene Model StatusCurrent Stock availability 5 publicly available
Genomic Location
Chromosome (arm)3RRecombination map
Cytogenetic map98D3-98D4Sequence location3R:24,346,387..24,366,053 [-]

Genomic Maps

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modENCODE GBrowse
detailed view
hide Summary Information
Automatically generated summary

See sections below for more information
The gene Papilin is referred to in FlyBase by the symbol Dmel\Ppn (CG33103, FBgn0003137). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: extracellular matrix structural constituent. There is experimental evidence that it is involved in the biological process: extracellular matrix organization. 8 alleles are reported. The phenotypes of these alleles are annotated with: Malpighian tubule; embryonic/larval tracheal system; embryonic/larval somatic muscle. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: ADAM-TS Spacer 1; Immunoglobulin I-set; Immunoglobulin subtype 2; Immunoglobulin-like; Immunoglobulin-like fold; PLAC; Peptidase M12B, ADAM-TS; Proteinase inhibitor I2, Kunitz metazoa; Proteinase inhibitor I2, Kunitz, conserved site; Thrombospondin, type 1 repeat; Whey acidic protein, 4-disulphide core. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed within 12-24 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult heart, larval trachea, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult central nervous system, larval/adult midgut, larval/adult hindgut, adult fat body, inseminated spermatheca. Comments on Affy2 ProbeSet: ProbeSet 1635210_a_at completely aligns to an exonic region common to each of the 4 FlyBase-annotated transcript isoforms of Ppn. Gene sequence location is 3R:24346387..24366053.

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Description
What does this section display?
This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).
What does this section not display?
This section does not currently display links that were removed or gene model changes.
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atom feed
FB2011_10
FB2012_01
Unknown
in situ
Sequence features
BKN21279
HFA15328
Controlled Vocabulary Terms
dorsal vessel primordium
organism
embryonic stage 8
embryonic/larval principal midgut epithelial cell
amnioproctodeal invagination
proventriculus intermediate layer
proventriculus primordium
keyhole structure
cephalic furrow
embryonic stage
adult stage
adult peritrophic membrane
embryonic/larval dorsal vessel
embryonic stage 12
embryonic stage 15
segmentally repeated
ventral furrow
mesoderm
hemocyte
proventriculus
embryonic stage 13
embryonic stage 14
embryonic stage 17
embryonic stage 10
embryonic stage 16
All updates Click here to see a list of all updates to this record from FB2010_08 and on.
hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
98D3-98D4  
Limits computationally determined from genome sequence between P{PZ}l(3)0648706487 and P{EP}EP3390EP3390  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
98D-98D  
 
(Kramerova et al., 1998)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
hide Gene Model & Products
Please see the GBrowse view of Dmel\Ppn for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
detailed view FBtr0301302 FBtr0301303 FBtr0085296 FBtr0300337 FBtr0301839 FBtr0301837 FBtr0301838 FBtr0085293 FBpp0290518 FBpp0290517 FBpp0084665 FBpp0289566 FBpp0291052 FBpp0291051 FBpp0291053 FBti0143282 FBti0101656 FBti0130094 FBti0100446
Comments on Gene Model
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
Ppn-RC
FBtr0300337
 NM_001170289
  7379
  2174
Ppn-RE
FBtr0301837
 NM_176575
  9551
  2898
Ppn-RF
FBtr0301838
 NM_176574
  9185
  2776
Ppn-RG
FBtr0301839
 NM_001170290
  9380
  2841
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
Ppn-PC  
FBpp0289566  
231.8  
2174  
4.10  
  NP_001163760
  ACZ95054
Ppn-PE  
FBpp0291051  
313.0  
2898  
4.19  
  NP_788752
  AAF56795
Ppn-PF  
FBpp0291052  
299.5  
2776  
4.18  
  NP_788751
  AAF56794
Ppn-PG  
FBpp0291053  
306.6  
2841  
4.17  
  NP_001163761
  ACZ95055
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
•
Thrombospondin, type 1 repeat (IPR000884)
Proteinase inhibitor I2, Kunitz metazoa (IPR002223)
Immunoglobulin subtype 2 (IPR003598)
Immunoglobulin-like (IPR007110)
Whey acidic protein, 4-disulphide core (IPR008197)
ADAM-TS Spacer 1 (IPR010294)
PLAC (IPR010909)
Peptidase M12B, ADAM-TS (IPR013273)
Immunoglobulin-like fold (IPR013783)
Proteinase inhibitor I2, Kunitz, conserved site (IPR020901)
Immunoglobulin I-set (IPR013098)
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
AA202349
 
AA803316
 
AA804112
 
AE014297
AAF56794
 
AE014297
AAF56795
 
AE014297
ACZ95054
 
AE014297
ACZ95055
 
AF205357
AAG37995
 
AF529179
AAO84907
 
AF529180
AAO84908
 
AI064596
 
AI114280
 
AI297402
 
AW940188
 
AY060635
AAL28183
 
BI230154
 
BI353761
 
BT011127
 
BT100225
 
BT126005
 
CO186296
 
CO188859
 
CO276347
 
CO277465
 
CO279943
 
CO287550
 
CO292296
 
CO292902
 
CO293967
 
CO295524
 
CO296455
 
CO301003
 
CO312954
 
CO313231
 
CO320656
 
CO323772
 
CO341337
 
CO344997
 
CO345468
 
EC057481
 
EC062516
 
EC068613
 
EC072299
 
EC081426
 
EC081497
 
EC081771
 
EC086188
 
EC086562
 
EC090439
 
EC195383
 
EC197808
 
EC201406
 
EC202641
 
EC204761
 
EC213059
 
EC217106
 
EC221266
 
EC222150
 
EC222470
 
EC224162
 
EC243413
 
EC247439
 
EC249759
 
EC251950
 
EC254724
 
EC257544
 
EC257582
 
ES696117
 
ES696119
 
ES696120
 
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
hide Mapped Features
Mapped Features have been reorganized, please see this article for details.
Additional mapped features and mutations can be found on GBrowse or related reports.
Type
Symbol & Location
Additional Notes
References
hide External Data
Linkouts
Crossreferences
hide Expression Data
hideTranscript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 8  
cephalic furrow  
(Kramerova et al., 2003)
Comment:probe does not distinguish isoforms
ventral furrow  
(Kramerova et al., 2003)
Comment:probe does not distinguish isoforms
amnioproctodeal invagination  
(Kramerova et al., 2003)
Comment:probe does not distinguish isoforms
embryonic stage 10  
mesoderm | segmentally repeated  
(Kramerova et al., 2003)
Comment:probe does not distinguish isoforms
embryonic stage 12 -- 14  
hemocyte  
(Kramerova et al., 2003)
Comment:NOT Ppn-RE
embryonic stage 14 -- 15  
dorsal vessel primordium  
(Kramerova et al., 2003)
Comment:probe specific to Ppn-RE
proventriculus primordium  
(Kramerova et al., 2003)
Comment:probe specific to Ppn-RE
embryonic stage 15  
keyhole structure  
(Kramerova et al., 2003)
Comment:probe specific to Ppn-RE
embryonic stage 16 -- 17  
proventriculus intermediate layer  
(Kramerova et al., 2003)
Comment:probe specific to Ppn-RE
embryonic/larval principal midgut epithelial cell  
(Kramerova et al., 2003)
Comment:probe specific to Ppn-RE
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage & adult stage  
organism  
(Kramerova et al., 2003)
Comment:embryonic, but not adult, expression includes shorter isoform
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
hidePolypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 16 -- 17  
proventriculus  
• basement membrane
(Kramerova et al., 2003)
embryonic/larval principal midgut epithelial cell  
(Kramerova et al., 2003)
embryonic stage 17  
embryonic/larval dorsal vessel  
(Kramerova et al., 2003)
Comment:luminal and abluminal surfaces
adult stage  
adult peritrophic membrane  
(Kramerova et al., 2003)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 5 of adulthood & male -- day 7 of adulthood & male  
spermatozoon  
(Wasbrough et al., 2010)
day 7 of adulthood -- day 49 of adulthood  
adult heart  
(Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
hide High-Throughput Expression Data
or
Untitled Document detailed view CG31051-RA Ppn-RC Ppn-RG Ppn-RE Ppn-RF
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

modENCODE Temporal Expression Data for FBgn0003137


   Styles
Linear
Logarithmic
Heatmap
   Scales
max expr for FBgn0003137
Very low expression bin max
Moderate expression bin max
High expression bin max
Extremely high expression bin max

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed within 12-24 hour embryonic stages.
[download data (TSV)]

Guide to modENCODE expression level colors
 
 No expression (0 - 0)
 
 Extremely low expression (1 - 10)
 
 Very low expression (11 - 100)
 
 Low expression (101 - 400)
 
 Moderate expression (401 - 1400)
 
 Moderately high expression (1401 - 4000)
 
 High expression (4001 - 10000)
 
 Very high expression (10001 - 100000)
 
 Extremely high expression (100001 - 2000000)

Linear, scaled to maximum FBgn0003137 expression level
Developmental Stage   Expression Level
embryo 00-02hr
 
 88
embryo 02-04hr
 
 281
embryo 04-06hr
 
 800
embryo 06-08hr
 
 3932
embryo 08-10hr
 
 5884
embryo 10-12hr
 
 7447
embryo 12-14hr
 
 12092
embryo 14-16hr
 
 23140
embryo 16-18hr
 
 21902
embryo 18-20hr
 
 19992
embryo 20-22hr
 
 6939
embryo 22-24hr
 
 6933
larva L1
 
 7370
larva L2
 
 5602
larva L3 12hr old
 
 6462
larva L3 puffstage 1-2
 
 1832
larva L3 puffstage 3-6
 
 1598
larva L3 puffstage 7-9
 
 1697
white prepupae new
 
 2210
white prepupae 12hr
 
 1396
white prepupae 24hr
 
 2174
pupae 2d postWPP
 
 2135
pupae 3d postWPP
 
 3682
pupae 4d postWPP
 
 4834
adult male 01day
 
 1987
adult male 05day
 
 1702
adult male 30day
 
 1163
adult female 01day
 
 2539
adult female 05day
 
 769
adult female 30day
 
 574
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
Linear, scaled to Very low expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 88
embryo 02-04hr
 (281)
embryo 04-06hr
 (800)
embryo 06-08hr
 (3932)
embryo 08-10hr
 (5884)
embryo 10-12hr
 (7447)
embryo 12-14hr
 (12092)
embryo 14-16hr
 (23140)
embryo 16-18hr
 (21902)
embryo 18-20hr
 (19992)
embryo 20-22hr
 (6939)
embryo 22-24hr
 (6933)
larva L1
 (7370)
larva L2
 (5602)
larva L3 12hr old
 (6462)
larva L3 puffstage 1-2
 (1832)
larva L3 puffstage 3-6
 (1598)
larva L3 puffstage 7-9
 (1697)
white prepupae new
 (2210)
white prepupae 12hr
 (1396)
white prepupae 24hr
 (2174)
pupae 2d postWPP
 (2135)
pupae 3d postWPP
 (3682)
pupae 4d postWPP
 (4834)
adult male 01day
 (1987)
adult male 05day
 (1702)
adult male 30day
 (1163)
adult female 01day
 (2539)
adult female 05day
 (769)
adult female 30day
 (574)
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
Linear, scaled to Moderate expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 88
embryo 02-04hr
 
 281
embryo 04-06hr
 
 800
embryo 06-08hr
 (3932)
embryo 08-10hr
 (5884)
embryo 10-12hr
 (7447)
embryo 12-14hr
 (12092)
embryo 14-16hr
 (23140)
embryo 16-18hr
 (21902)
embryo 18-20hr
 (19992)
embryo 20-22hr
 (6939)
embryo 22-24hr
 (6933)
larva L1
 (7370)
larva L2
 (5602)
larva L3 12hr old
 (6462)
larva L3 puffstage 1-2
 (1832)
larva L3 puffstage 3-6
 (1598)
larva L3 puffstage 7-9
 (1697)
white prepupae new
 (2210)
white prepupae 12hr
 
 1396
white prepupae 24hr
 (2174)
pupae 2d postWPP
 (2135)
pupae 3d postWPP
 (3682)
pupae 4d postWPP
 (4834)
adult male 01day
 (1987)
adult male 05day
 (1702)
adult male 30day
 
 1163
adult female 01day
 (2539)
adult female 05day
 
 769
adult female 30day
 
 574
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
Linear, scaled to High expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 88
embryo 02-04hr
 
 281
embryo 04-06hr
 
 800
embryo 06-08hr
 
 3932
embryo 08-10hr
 
 5884
embryo 10-12hr
 
 7447
embryo 12-14hr
 (12092)
embryo 14-16hr
 (23140)
embryo 16-18hr
 (21902)
embryo 18-20hr
 (19992)
embryo 20-22hr
 
 6939
embryo 22-24hr
 
 6933
larva L1
 
 7370
larva L2
 
 5602
larva L3 12hr old
 
 6462
larva L3 puffstage 1-2
 
 1832
larva L3 puffstage 3-6
 
 1598
larva L3 puffstage 7-9
 
 1697
white prepupae new
 
 2210
white prepupae 12hr
 
 1396
white prepupae 24hr
 
 2174
pupae 2d postWPP
 
 2135
pupae 3d postWPP
 
 3682
pupae 4d postWPP
 
 4834
adult male 01day
 
 1987
adult male 05day
 
 1702
adult male 30day
 
 1163
adult female 01day
 
 2539
adult female 05day
 
 769
adult female 30day
 
 574
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
Linear, scaled to Extremely high expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 88
embryo 02-04hr
 
 281
embryo 04-06hr
 
 800
embryo 06-08hr
 
 3932
embryo 08-10hr
 
 5884
embryo 10-12hr
 
 7447
embryo 12-14hr
 
 12092
embryo 14-16hr
 
 23140
embryo 16-18hr
 
 21902
embryo 18-20hr
 
 19992
embryo 20-22hr
 
 6939
embryo 22-24hr
 
 6933
larva L1
 
 7370
larva L2
 
 5602
larva L3 12hr old
 
 6462
larva L3 puffstage 1-2
 
 1832
larva L3 puffstage 3-6
 
 1598
larva L3 puffstage 7-9
 
 1697
white prepupae new
 
 2210
white prepupae 12hr
 
 1396
white prepupae 24hr
 
 2174
pupae 2d postWPP
 
 2135
pupae 3d postWPP
 
 3682
pupae 4d postWPP
 
 4834
adult male 01day
 
 1987
adult male 05day
 
 1702
adult male 30day
 
 1163
adult female 01day
 
 2539
adult female 05day
 
 769
adult female 30day
 
 574
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
 Extremely high 
log, scaled to maximum FBgn0003137 expression level
Developmental Stage   Expression Level
embryo 00-02hr
 
 88
embryo 02-04hr
 
 281
embryo 04-06hr
 
 800
embryo 06-08hr
 
 3932
embryo 08-10hr
 
 5884
embryo 10-12hr
 
 7447
embryo 12-14hr
 
 12092
embryo 14-16hr
 
 23140
embryo 16-18hr
 
 21902
embryo 18-20hr
 
 19992
embryo 20-22hr
 
 6939
embryo 22-24hr
 
 6933
larva L1
 
 7370
larva L2
 
 5602
larva L3 12hr old
 
 6462
larva L3 puffstage 1-2
 
 1832
larva L3 puffstage 3-6
 
 1598
larva L3 puffstage 7-9
 
 1697
white prepupae new
 
 2210
white prepupae 12hr
 
 1396
white prepupae 24hr
 
 2174
pupae 2d postWPP
 
 2135
pupae 3d postWPP
 
 3682
pupae 4d postWPP
 
 4834
adult male 01day
 
 1987
adult male 05day
 
 1702
adult male 30day
 
 1163
adult female 01day
 
 2539
adult female 05day
 
 769
adult female 30day
 
 574
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Very low expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 88
embryo 02-04hr
 (281)
embryo 04-06hr
 (800)
embryo 06-08hr
 (3932)
embryo 08-10hr
 (5884)
embryo 10-12hr
 (7447)
embryo 12-14hr
 (12092)
embryo 14-16hr
 (23140)
embryo 16-18hr
 (21902)
embryo 18-20hr
 (19992)
embryo 20-22hr
 (6939)
embryo 22-24hr
 (6933)
larva L1
 (7370)
larva L2
 (5602)
larva L3 12hr old
 (6462)
larva L3 puffstage 1-2
 (1832)
larva L3 puffstage 3-6
 (1598)
larva L3 puffstage 7-9
 (1697)
white prepupae new
 (2210)
white prepupae 12hr
 (1396)
white prepupae 24hr
 (2174)
pupae 2d postWPP
 (2135)
pupae 3d postWPP
 (3682)
pupae 4d postWPP
 (4834)
adult male 01day
 (1987)
adult male 05day
 (1702)
adult male 30day
 (1163)
adult female 01day
 (2539)
adult female 05day
 (769)
adult female 30day
 (574)
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
log, scaled to Moderate expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 88
embryo 02-04hr
 
 281
embryo 04-06hr
 
 800
embryo 06-08hr
 (3932)
embryo 08-10hr
 (5884)
embryo 10-12hr
 (7447)
embryo 12-14hr
 (12092)
embryo 14-16hr
 (23140)
embryo 16-18hr
 (21902)
embryo 18-20hr
 (19992)
embryo 20-22hr
 (6939)
embryo 22-24hr
 (6933)
larva L1
 (7370)
larva L2
 (5602)
larva L3 12hr old
 (6462)
larva L3 puffstage 1-2
 1832
larva L3 puffstage 3-6
 1598
larva L3 puffstage 7-9
 1697
white prepupae new
 2210
white prepupae 12hr
 
 1396
white prepupae 24hr
 2174
pupae 2d postWPP
 2135
pupae 3d postWPP
 (3682)
pupae 4d postWPP
 (4834)
adult male 01day
 1987
adult male 05day
 1702
adult male 30day
 
 1163
adult female 01day
 (2539)
adult female 05day
 
 769
adult female 30day
 
 574
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
log, scaled to High expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 88
embryo 02-04hr
 
 281
embryo 04-06hr
 
 800
embryo 06-08hr
 
 3932
embryo 08-10hr
 
 5884
embryo 10-12hr
 
 7447
embryo 12-14hr
 12092
embryo 14-16hr
 (23140)
embryo 16-18hr
 (21902)
embryo 18-20hr
 19992
embryo 20-22hr
 
 6939
embryo 22-24hr
 
 6933
larva L1
 
 7370
larva L2
 
 5602
larva L3 12hr old
 
 6462
larva L3 puffstage 1-2
 
 1832
larva L3 puffstage 3-6
 
 1598
larva L3 puffstage 7-9
 
 1697
white prepupae new
 
 2210
white prepupae 12hr
 
 1396
white prepupae 24hr
 
 2174
pupae 2d postWPP
 
 2135
pupae 3d postWPP
 
 3682
pupae 4d postWPP
 
 4834
adult male 01day
 
 1987
adult male 05day
 
 1702
adult male 30day
 
 1163
adult female 01day
 
 2539
adult female 05day
 
 769
adult female 30day
 
 574
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Extremely high expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 88
embryo 02-04hr
 
 281
embryo 04-06hr
 
 800
embryo 06-08hr
 
 3932
embryo 08-10hr
 
 5884
embryo 10-12hr
 
 7447
embryo 12-14hr
 
 12092
embryo 14-16hr
 
 23140
embryo 16-18hr
 
 21902
embryo 18-20hr
 
 19992
embryo 20-22hr
 
 6939
embryo 22-24hr
 
 6933
larva L1
 
 7370
larva L2
 
 5602
larva L3 12hr old
 
 6462
larva L3 puffstage 1-2
 
 1832
larva L3 puffstage 3-6
 
 1598
larva L3 puffstage 7-9
 
 1697
white prepupae new
 
 2210
white prepupae 12hr
 
 1396
white prepupae 24hr
 
 2174
pupae 2d postWPP
 
 2135
pupae 3d postWPP
 
 3682
pupae 4d postWPP
 
 4834
adult male 01day
 
 1987
adult male 05day
 
 1702
adult male 30day
 
 1163
adult female 01day
 
 2539
adult female 05day
 
 769
adult female 30day
 
 574
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
 Extremely high 
Heatmap
Developmental Stage   Expression Level
embryo 00-02hr
 
 
embryo 02-04hr
 
 
embryo 04-06hr
 
 
embryo 06-08hr
 
 
embryo 08-10hr
 
 
embryo 10-12hr
 
 
embryo 12-14hr
 
 
embryo 14-16hr
 
 
embryo 16-18hr
 
 
embryo 18-20hr
 
 
embryo 20-22hr
 
 
embryo 22-24hr
 
 
larva L1
 
 
larva L2
 
 
larva L3 12hr old
 
 
larva L3 puffstage 1-2
 
 
larva L3 puffstage 3-6
 
 
larva L3 puffstage 7-9
 
 
white prepupae new
 
 
white prepupae 12hr
 
 
white prepupae 24hr
 
 
pupae 2d postWPP
 
 
pupae 3d postWPP
 
 
pupae 4d postWPP
 
 
adult male 01day
 
 
adult male 05day
 
 
adult male 30day
 
 
adult female 01day
 
 
adult female 05day
 
 
adult female 30day
 
 

FlyAtlas Anatomical Expression Data for FBgn0003137


   Styles
Linear
Logarithmic
Heatmap
Back-to-back
   Scales
max expr for FBgn0003137
Moderate expression bin max
High level expression bin max
Very high expression bin max

Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult heart, larval trachea, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult central nervous system, larval/adult midgut, larval/adult hindgut, adult fat body, inseminated spermatheca.
[download data (TSV)]

Guide to FlyAtlas expression level colors
 
 No expression (0 - 9.999)
 
 Low expression (10 - 99.999)
 
 Moderate expression (100 - 499.999)
 
 High level expression (500 - 999.999)
 
 Very high expression (1000 - 25000)

Linear, scaled to maximum FBgn0003137 expression level
Tissue   Expression Level
Larval Central Nervous System
 
 28.6
Larval Midgut
 
 130.7
Larval Hindgut
 
 234.1
Larval Malpighian Tubules
 
 26.6
Larval Fat Body
 
 38.5
Larval Salivary Gland
 
 13.5
Larval Trachea
 
 1183.875
Larval Carcass
 
 698.5
Adult Head
 
 864.5
Adult Eye
 
 256.625
Adult Brain
 
 313.2
Adult Thoracic-Abdominal Ganglion
 
 158.8
Adult Crop
 
 73.9
Adult Midgut
 
 196.2
Adult Hindgut
 
 105.4
Adult Malpighian Tubules
 
 26
Adult Fat Body
 
 176.1
Adult Salivary Gland
 
 76
Adult Heart
 
 2907.925
Adult VirginFemale Spermatheca
 
 92.1
Adult InseminatedFemale Spermatheca
 
 107
Adult Ovary
 
 49.6
Adult Testis
 
 93.2
Adult Male Accessory Gland
 
 17
Adult Carcass
 
 1036.5
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
Linear, scaled to Moderate expression
Tissue   Expression Level
Larval Central Nervous System
 
 28.6
Larval Midgut
 
 130.7
Larval Hindgut
 
 234.1
Larval Malpighian Tubules
 
 26.6
Larval Fat Body
 
 38.5
Larval Salivary Gland
 
 13.5
Larval Trachea
 (1183.875)
Larval Carcass
 (698.5)
Adult Head
 (864.5)
Adult Eye
 
 256.625
Adult Brain
 
 313.2
Adult Thoracic-Abdominal Ganglion
 
 158.8
Adult Crop
 
 73.9
Adult Midgut
 
 196.2
Adult Hindgut
 
 105.4
Adult Malpighian Tubules
 
 26
Adult Fat Body
 
 176.1
Adult Salivary Gland
 
 76
Adult Heart
 (2907.925)
Adult VirginFemale Spermatheca
 
 92.1
Adult InseminatedFemale Spermatheca
 
 107
Adult Ovary
 
 49.6
Adult Testis
 
 93.2
Adult Male Accessory Gland
 
 17
Adult Carcass
 (1036.5)
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
Linear, scaled to High level expression
Tissue   Expression Level
Larval Central Nervous System
 
 28.6
Larval Midgut
 
 130.7
Larval Hindgut
 
 234.1
Larval Malpighian Tubules
 
 26.6
Larval Fat Body
 
 38.5
Larval Salivary Gland
 
 13.5
Larval Trachea
 (1183.875)
Larval Carcass
 
 698.5
Adult Head
 
 864.5
Adult Eye
 
 256.625
Adult Brain
 
 313.2
Adult Thoracic-Abdominal Ganglion
 
 158.8
Adult Crop
 
 73.9
Adult Midgut
 
 196.2
Adult Hindgut
 
 105.4
Adult Malpighian Tubules
 
 26
Adult Fat Body
 
 176.1
Adult Salivary Gland
 
 76
Adult Heart
 (2907.925)
Adult VirginFemale Spermatheca
 
 92.1
Adult InseminatedFemale Spermatheca
 
 107
Adult Ovary
 
 49.6
Adult Testis
 
 93.2
Adult Male Accessory Gland
 
 17
Adult Carcass
 1036.5
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
Linear, scaled to Very high expression
Tissue   Expression Level
Larval Central Nervous System
 
 28.6
Larval Midgut
 
 130.7
Larval Hindgut
 
 234.1
Larval Malpighian Tubules
 
 26.6
Larval Fat Body
 
 38.5
Larval Salivary Gland
 
 13.5
Larval Trachea
 
 1183.875
Larval Carcass
 
 698.5
Adult Head
 
 864.5
Adult Eye
 
 256.625
Adult Brain
 
 313.2
Adult Thoracic-Abdominal Ganglion
 
 158.8
Adult Crop
 
 73.9
Adult Midgut
 
 196.2
Adult Hindgut
 
 105.4
Adult Malpighian Tubules
 
 26
Adult Fat Body
 
 176.1
Adult Salivary Gland
 
 76
Adult Heart
 
 2907.925
Adult VirginFemale Spermatheca
 
 92.1
Adult InseminatedFemale Spermatheca
 
 107
Adult Ovary
 
 49.6
Adult Testis
 
 93.2
Adult Male Accessory Gland
 
 17
Adult Carcass
 
 1036.5
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
log, scaled to maximum FBgn0003137 expression level
Tissue   Expression Level
Larval Central Nervous System
 
 28.6
Larval Midgut
 
 130.7
Larval Hindgut
 
 234.1
Larval Malpighian Tubules
 
 26.6
Larval Fat Body
 
 38.5
Larval Salivary Gland
 
 13.5
Larval Trachea
 
 1183.875
Larval Carcass
 
 698.5
Adult Head
 
 864.5
Adult Eye
 
 256.625
Adult Brain
 
 313.2
Adult Thoracic-Abdominal Ganglion
 
 158.8
Adult Crop
 
 73.9
Adult Midgut
 
 196.2
Adult Hindgut
 
 105.4
Adult Malpighian Tubules
 
 26
Adult Fat Body
 
 176.1
Adult Salivary Gland
 
 76
Adult Heart
 
 2907.925
Adult VirginFemale Spermatheca
 
 92.1
Adult InseminatedFemale Spermatheca
 
 107
Adult Ovary
 
 49.6
Adult Testis
 
 93.2
Adult Male Accessory Gland
 
 17
Adult Carcass
 
 1036.5
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
log, scaled to Moderate expression
Tissue   Expression Level
Larval Central Nervous System
 
 28.6
Larval Midgut
 
 130.7
Larval Hindgut
 
 234.1
Larval Malpighian Tubules
 
 26.6
Larval Fat Body
 
 38.5
Larval Salivary Gland
 
 13.5
Larval Trachea
 (1183.875)
Larval Carcass
 698.5
Adult Head
 (864.5)
Adult Eye
 
 256.625
Adult Brain
 
 313.2
Adult Thoracic-Abdominal Ganglion
 
 158.8
Adult Crop
 
 73.9
Adult Midgut
 
 196.2
Adult Hindgut
 
 105.4
Adult Malpighian Tubules
 
 26
Adult Fat Body
 
 176.1
Adult Salivary Gland
 
 76
Adult Heart
 (2907.925)
Adult VirginFemale Spermatheca
 
 92.1
Adult InseminatedFemale Spermatheca
 
 107
Adult Ovary
 
 49.6
Adult Testis
 
 93.2
Adult Male Accessory Gland
 
 17
Adult Carcass
 (1036.5)
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
log, scaled to High level expression
Tissue   Expression Level
Larval Central Nervous System
 
 28.6
Larval Midgut
 
 130.7
Larval Hindgut
 
 234.1
Larval Malpighian Tubules
 
 26.6
Larval Fat Body
 
 38.5
Larval Salivary Gland
 
 13.5
Larval Trachea
 1183.875
Larval Carcass
 
 698.5
Adult Head
 
 864.5
Adult Eye
 
 256.625
Adult Brain
 
 313.2
Adult Thoracic-Abdominal Ganglion
 
 158.8
Adult Crop
 
 73.9
Adult Midgut
 
 196.2
Adult Hindgut
 
 105.4
Adult Malpighian Tubules
 
 26
Adult Fat Body
 
 176.1
Adult Salivary Gland
 
 76
Adult Heart
 (2907.925)
Adult VirginFemale Spermatheca
 
 92.1
Adult InseminatedFemale Spermatheca
 
 107
Adult Ovary
 
 49.6
Adult Testis
 
 93.2
Adult Male Accessory Gland
 
 17
Adult Carcass
 1036.5
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
log, scaled to Very high expression
Tissue   Expression Level
Larval Central Nervous System
 
 28.6
Larval Midgut
 
 130.7
Larval Hindgut
 
 234.1
Larval Malpighian Tubules
 
 26.6
Larval Fat Body
 
 38.5
Larval Salivary Gland
 
 13.5
Larval Trachea
 
 1183.875
Larval Carcass
 
 698.5
Adult Head
 
 864.5
Adult Eye
 
 256.625
Adult Brain
 
 313.2
Adult Thoracic-Abdominal Ganglion
 
 158.8
Adult Crop
 
 73.9
Adult Midgut
 
 196.2
Adult Hindgut
 
 105.4
Adult Malpighian Tubules
 
 26
Adult Fat Body
 
 176.1
Adult Salivary Gland
 
 76
Adult Heart
 
 2907.925
Adult VirginFemale Spermatheca
 
 92.1
Adult InseminatedFemale Spermatheca
 
 107
Adult Ovary
 
 49.6
Adult Testis
 
 93.2
Adult Male Accessory Gland
 
 17
Adult Carcass
 
 1036.5
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
Heatmap
Tissue   Expression Level
Larval Central Nervous System
 
 
Larval Midgut
 
 
Larval Hindgut
 
 
Larval Malpighian Tubules
 
 
Larval Fat Body
 
 
Larval Salivary Gland
 
 
Larval Trachea
 
 
Larval Carcass
 
 
Adult Head
 
 
Adult Eye
 
 
Adult Brain
 
 
Adult Thoracic-Abdominal Ganglion
 
 
Adult Crop
 
 
Adult Midgut
 
 
Adult Hindgut
 
 
Adult Malpighian Tubules
 
 
Adult Fat Body
 
 
Adult Salivary Gland
 
 
Adult Heart
 
 
Adult VirginFemale Spermatheca
 
 
Adult InseminatedFemale Spermatheca
 
 
Adult Ovary
 
 
Adult Testis
 
 
Adult Male Accessory Gland
 
 
Adult Carcass
 
 

FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level Tissue Adult Expression Level
 
NA 		 Head
 
 864.5
 
NA 		 Eye
 
 256.625
 
NA 		 Brain
 
 313.2
 
28.6 		 Central Nervous System
 
 NA
 
NA 		 Thoracic-Abdominal Ganglion
 
 158.8
 
NA 		 Crop
 
 73.9
 
130.7 		 Midgut
 
 196.2
 
234.1 		 Hindgut
 
 105.4
 
26.6 		 Malpighian Tubules
 
 26
 
38.5 		 Fat Body
 
 176.1
 
13.5 		 Salivary Gland
 
 76
 
NA 		 Heart
 
 2907.925
 
1183.875 		 Trachea
 
 NA
 
NA 		 VirginFemale Spermatheca
 
 92.1
 
NA 		 InseminatedFemale Spermatheca
 
 107
 
NA 		 Ovary
 
 49.6
 
NA 		 Testis
 
 93.2
 
NA 		 Male Accessory Gland
 
 17
 
698.5 		 Carcass
 
 1036.5

modENCODE Temporal Expression Data (Graveley et al., 2011)
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
hide Expression Clusters
A cluster of genes with similar mRNA expression dynamics across development.
(The modENCODE Consortium, 2010)
hide External Data & Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
•
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
•
hide Alleles & Phenotypes
hide Summary of Allele Phenotypes
Lethality
Allele
lethal | embryonic stage | recessive, with Scer\GAL4Act5C.PI
lethal | embryonic stage | recessive, with Scer\GAL4da.G32
lethal | pupal stage, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
embryonic/larval somatic muscle
embryonic/larval somatic muscle, with Scer\GAL4Act5C.PI
embryonic/larval somatic muscle, with Scer\GAL4da.G32
embryonic/larval tracheal system, with Scer\GAL4Act5C.PI
embryonic/larval tracheal system, with Scer\GAL4da.G32
Malpighian tubule, with Scer\GAL4Act5C.PI
Malpighian tubule, with Scer\GAL4da.G32
hide Classical Alleles ( 3 )
For All Classical Alleles Show

Allele of PpnClassMutagenStocksKnown lesion
PpnG42591 --
PpnMB07666
1 --
PpnMI03189
1 --
hide Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show

Allele of PpnClassMutagenStocksKnown lesion
PpnGD63251 Yes
PpnKK1012281 Yes
Ppna.Scer\UAS0 Yes
PpndsRNA.cKa0 Yes
PpnScer\UAS.cKa0 Yes
hide Aneuploid Aberrations
Disrupted in
(Ryder, 2004.4.26)
hide Transgenic Constructs & Insertions
Transgenic Constructs
Type of construct
Name
Expression data
UAS construct
P{GD6325}
NA
P{KK101228}
NA
P{UAS-Ppn.anti.K}
NA
P{UAS-Ppn.K}
NA
Insertions
Type of insertions
Name
Expression data
insertion of enhancer trap binary system
Mi{ET1}PpnMB07666
No
insertion of mobile activating element
P{EP}PpnG4259
NA
miscellaneous insertions
Mi{MIC}PpnMI03189
NA
hide Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
hide Terms Based on Experimental Evidence ( 3 terms )
Molecular Function
CV term
Evidence
References
extracellular matrix structural constituent
inferred from mutant phenotype
(assigned by UniProtKB)
(Kramerova et al., 2000)
Biological Process
CV term
Evidence
References
extracellular matrix organization
inferred from mutant phenotype
(assigned by UniProtKB)
(Kramerova et al., 2000)
Cellular Component
CV term
Evidence
References
basement membrane
inferred from direct assay
(Campbell et al., 1987)
inferred from direct assay
(assigned by UniProtKB)
(Kramerova et al., 2000)
hide Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term
Evidence
References
metalloendopeptidase activity
inferred from electronic annotation with InterPro:IPR010294
(FlyBase Curators et al., 2004-)
serine-type endopeptidase inhibitor activity
inferred from electronic annotation with InterPro:IPR002223
(FlyBase Curators et al., 2004-)
zinc ion binding
inferred from electronic annotation with InterPro:IPR013273
(FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component
CV term
Evidence
References
proteinaceous extracellular matrix
non-traceable author statement
(Robertson, 2000.4.15, Kramerova, 1999.11.15)
hide Sequence Ontology: Class of Gene
nuclear_gene
 
protein_coding_gene
 
hide Interactions & Pathways
hide Summary of Physical Interactions
Protein-protein
Interacting group
Assay
References
hide Summary of Genetic Interactions
Interacts with
Please look at the allele data for full details of the genetic interactions
Ppn allele
Gene
References
hide External Data
Linkouts
BioGRID - A database of protein and genetic interactions
•
DroID - A comprehensive database of gene and protein interactions.
•
InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.
•
hide Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs
 
Linkouts
OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs.
•
hide Stocks & Reagents
hide Stocks Listed in FlyBase ( 5 )
Bloomington
25277
w1118; Mi{ET1}PpnMB07666
31782
w1118; P{EP}PpnG4259/TM6C, Sb1
36216
y1 w*; Mi{MIC}PpnMI03189/TM3, Sb1 Ser1
VDRC
v108005
P{KK101228}VIE-260B
v16523
w1118; P{GD6325}v16523
hide Genomic Clones ( 1 )

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
hide cDNA Clones ( 57 )

Please Note
This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
hide RNAi & Array Information
Linkouts
DRSC - Results from RNAi screens.
•
GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
•
hide Antibody Information
polyclonal
(Gullberg et al., 1994)
hide Other Information
hide Discoverer
hide Etymology
hide Identification
hide Relationship to Other Genes
Source for database identity of
Source for identity of: lacunin CG1540
(Hynes and Zhao, 2000)
Source for database merge of
Source for merge of: CG1540 CG18436
(Whitfield, 2000.10.31)
Source for merge of: Ppn lacunin
(Kramerova et al., 2000)
Additional comments
Annotation CG1540 split into CG31051 and CG33103 (Ppn) in release 3 of the genome annotation.
(FlyBase Genome Annotators, 2002-2003)
Relationship of "Mdp-1" with "Ppn" is unclear; mAb 5H7 recognises "Mdp-1" protein in embryo protein extracts, and "Ppn" in Kc cell protein extracts. However biochemical analysis of the two proteins reveals a number of significant differences between the two molecules. "Ppn" and "Mdp-1" may therefore represent two different genes, or "Mdp-1" protein may be the naturally occurring form of "Ppn", which is secreted by Kc cells in culture.
(Hortsch et al., 1998)
hide Other Comments
The Ppn gene product influences cell rearrangements and may modulate metalloproteinases during organogenesis.
(Kramerova et al., 2000)
Ppn protein, a sulfated glycoprotein, has been isolated from the culture media of Drosophila Kc cells, and its expression in embryos and larvae has been studied.
(Campbell et al., 1987)
hide External Crossreferences & Linkouts
Sequence Crossreferences
RefSeq (Transcripts)
•
RefSeq (Proteins)
•
DDBJ / EMBL / GenBank
•
Entrez Gene - A searchable database of RefSeq genes.
•
UniProtKB/TrEMBL
•
Other Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
•
Thrombospondin, type 1 repeat (IPR000884)
Proteinase inhibitor I2, Kunitz metazoa (IPR002223)
Immunoglobulin subtype 2 (IPR003598)
Immunoglobulin-like (IPR007110)
Whey acidic protein, 4-disulphide core (IPR008197)
ADAM-TS Spacer 1 (IPR010294)
PLAC (IPR010909)
Peptidase M12B, ADAM-TS (IPR013273)
Immunoglobulin-like fold (IPR013783)
Proteinase inhibitor I2, Kunitz, conserved site (IPR020901)
Immunoglobulin I-set (IPR013098)
Linkouts
BioGRID - A database of protein and genetic interactions
•
DroID - A comprehensive database of gene and protein interactions.
•
DRSC - Results from RNAi screens.
•
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
•
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
•
FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans
•
GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
•
InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.
•
modMine - Data generated by the modENCODE project.
•
OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs.
•
hide Synonyms & Secondary IDs ( 12 )
Reported As
Symbol Synonym
CG1540
 
CG18436
(Whitfield, 2000.10.31, )
CG33103
(Fakhouri et al., 2006, Keleman et al., 2009.8.5, Cammarato et al., 2011)
CT3186
(Hynes and Zhao, 2000)
CT41988
(Hynes and Zhao, 2000)
ppl
(Kramerova et al., 1998)
Ppn
(Firth and Baker, 2007, Kwon et al., 2008, Liu et al., 2009, Leatherbarrow and Halfon, 2009, Wasbrough et al., 2010)
ppn
(Leatherbarrow and Halfon, 2009, Firth and Baker, 2007)
Name Synonym
lacunin
(Robertson, 2000.4.15, )
lacunin-like
(Hynes and Zhao, 2000)
papilin
(Kramerov and Fessler, 2001, Kramerova, 1999.11.15, Campbell et al., 1987, Kramerova et al., 2003, Gullberg et al., 1994, Firth and Baker, 2007)
Papilin
(Brown et al., 2000, Fakhouri et al., 2006, Yasuhara and Wakimoto, 2008, Yoshida et al., 2008, Cammarato et al., 2011)
Secondary FlyBase IDs
  • FBgn0039586
  • FBgn0039587
  • FBgn0053103
hide References ( 45 )
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hide Recent research papers ( 1 )
Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784
GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834]
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