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Gene Dmel\Ppn

General Information
Symbol	Dmel\Ppn	Species	D. melanogaster
Name	Papilin	Annotation symbol	CG33103
Feature type	protein_coding_gene	FlyBase ID	FBgn0003137
Gene Model Status	Current	Stock availability	5 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	98D3-98D4	Sequence location	3R:24,346,387..24,366,046 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Papilin is referred to in FlyBase by the symbol Dmel\Ppn (CG33103, FBgn0003137). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: extracellular matrix structural constituent. There is experimental evidence that it is involved in the biological process: extracellular matrix organization. 9 alleles are reported. The phenotypes of these alleles are annotated with: Malpighian tubule; embryonic/larval tracheal system; embryonic/larval somatic muscle. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: ADAM-TS Spacer 1; Immunoglobulin I-set; Immunoglobulin subtype 2; Immunoglobulin-like domain; Immunoglobulin-like fold; PLAC; Peptidase M12B, ADAM-TS; Proteinase inhibitor I2, Kunitz metazoa; Proteinase inhibitor I2, Kunitz, conserved site; Thrombospondin, type 1 repeat; Whey acidic protein-type 4-disulphide core. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed within 12-24 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult heart, larval trachea, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult central nervous system, larval/adult midgut, larval/adult hindgut, adult fat body, inseminated spermatheca. Comments on Affy2 ProbeSet: ProbeSet 1635210_a_at completely aligns to an exonic region common to each of the 4 FlyBase-annotated transcript isoforms of Ppn. Gene sequence location is 3R:24346387..24366046.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 98D3-98D4   Limits computationally determined from genome sequence between P{PZ}l(3)0648706487 and P{EP}EP3390EP3390
Experimentally Determined Cytological Location
Cytogenetic map Notes References 98D-98D     (Kramerova et al., 1998)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Ppn for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.48 Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters. Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Ppn-RC FBtr0300337  NM_001170289   7372   2174 Ppn-RE FBtr0301837  NM_176575   9544   2898 Ppn-RF FBtr0301838  NM_176574   9178   2776 Ppn-RG FBtr0301839  NM_001170290   9373   2841
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Ppn-PC   FBpp0289566   231.8   2174   4.10     NP_001163760   ACZ95054 Ppn-PE   FBpp0291051   313.0   2898   4.19     NP_788752   AAF56795 Ppn-PF   FBpp0291052   299.5   2776   4.18     NP_788751   AAF56794 Ppn-PG   FBpp0291053   306.6   2841   4.17     NP_001163761   ACZ95055
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Thrombospondin, type 1 repeat (IPR000884) Proteinase inhibitor I2, Kunitz metazoa (IPR002223) Immunoglobulin subtype 2 (IPR003598) Immunoglobulin-like domain (IPR007110) Whey acidic protein-type 4-disulphide core (IPR008197) ADAM-TS Spacer 1 (IPR010294) PLAC (IPR010909) Peptidase M12B, ADAM-TS (IPR013273) Immunoglobulin-like fold (IPR013783) Proteinase inhibitor I2, Kunitz, conserved site (IPR020901) Immunoglobulin I-set (IPR013098)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202349   AA803316   AA804112   AE014297 AAF56794   AE014297 AAF56795   AE014297 ACZ95054   AE014297 ACZ95055   AF205357 AAG37995   AF529179 AAO84907   AF529180 AAO84908   AI064596   AI114280   AI297402   AW940188   AY060635 AAL28183   BI230154   BI353761   BT011127   BT100225   BT126005   CO186296   CO188859   CO276347   CO277465   CO279943   CO287550   CO292296   CO292902   CO293967   CO295524   CO296455   CO301003   CO312954   CO313231   CO320656   CO323772   CO341337   CO344997   CO345468   EC057481   EC062516   EC068613   EC072299   EC081426   EC081497   EC081771   EC086188   EC086562   EC090439   EC195383   EC197808   EC201406   EC202641   EC204761   EC213059   EC217106   EC221266   EC222150   EC222470   EC224162   EC243413   EC247439   EC249759   EC251950   EC254724   EC257544   EC257582   ES696117   ES696119   ES696120
UniProtKB/Swiss-Prot	Q868Z9
UniProtKB/TrEMBL	Q95SR4
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 8   cephalic furrow   (Kramerova et al., 2003) Comment:probe does not distinguish isoforms ventral furrow   (Kramerova et al., 2003) Comment:probe does not distinguish isoforms amnioproctodeal invagination   (Kramerova et al., 2003) Comment:probe does not distinguish isoforms embryonic stage 10   mesoderm | segmentally repeated   (Kramerova et al., 2003) Comment:probe does not distinguish isoforms embryonic stage 12 -- 14   hemocyte   (Kramerova et al., 2003) Comment:NOT Ppn-RE embryonic stage 14 -- 15   dorsal vessel primordium   (Kramerova et al., 2003) Comment:probe specific to Ppn-RE proventriculus primordium   (Kramerova et al., 2003) Comment:probe specific to Ppn-RE embryonic stage 15   keyhole structure   (Kramerova et al., 2003) Comment:probe specific to Ppn-RE embryonic stage 16 -- 17   proventriculus intermediate layer   (Kramerova et al., 2003) Comment:probe specific to Ppn-RE embryonic/larval principal midgut epithelial cell   (Kramerova et al., 2003) Comment:probe specific to Ppn-RE northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage & adult stage   organism   (Kramerova et al., 2003) Comment:embryonic, but not adult, expression includes shorter isoform
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 16 -- 17   proventriculus   • basement membrane (Kramerova et al., 2003) embryonic/larval principal midgut epithelial cell   (Kramerova et al., 2003) embryonic stage 17   embryonic/larval dorsal vessel   (Kramerova et al., 2003) Comment:luminal and abluminal surfaces adult stage   adult peritrophic membrane   (Kramerova et al., 2003) mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010) day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
basement membrane inferred from direct assay (Campbell et al., 1987) inferred from direct assay (assigned by UniProtKB) (Kramerova et al., 2000)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult heart, larval trachea, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult central nervous system, larval/adult midgut, larval/adult hindgut, adult fat body, inseminated spermatheca. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    28.6 Larval Midgut    130.7 Larval Hindgut    234.1 Larval Malpighian Tubules    26.6 Larval Fat Body    38.5 Larval Salivary Gland    13.5 Larval Trachea    1183.875 Larval Carcass    698.5 Adult Head    864.5 Adult Eye    256.625 Adult Brain    313.2 Adult Thoracic-Abdominal Ganglion    158.8 Adult Crop    73.9 Adult Midgut    196.2 Adult Hindgut    105.4 Adult Malpighian Tubules    26 Adult Fat Body    176.1 Adult Salivary Gland    76 Adult Heart    2907.925 Adult VirginFemale Spermatheca    92.1 Adult InseminatedFemale Spermatheca    107 Adult Ovary    49.6 Adult Testis    93.2 Adult Male Accessory Gland    17 Adult Carcass    1036.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    28.6 Larval Midgut    130.7 Larval Hindgut    234.1 Larval Malpighian Tubules    26.6 Larval Fat Body    38.5 Larval Salivary Gland    13.5 Larval Trachea  (1183.875) Larval Carcass  (698.5) Adult Head  (864.5) Adult Eye    256.625 Adult Brain    313.2 Adult Thoracic-Abdominal Ganglion    158.8 Adult Crop    73.9 Adult Midgut    196.2 Adult Hindgut    105.4 Adult Malpighian Tubules    26 Adult Fat Body    176.1 Adult Salivary Gland    76 Adult Heart  (2907.925) Adult VirginFemale Spermatheca    92.1 Adult InseminatedFemale Spermatheca    107 Adult Ovary    49.6 Adult Testis    93.2 Adult Male Accessory Gland    17 Adult Carcass  (1036.5) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    28.6 Larval Midgut    130.7 Larval Hindgut    234.1 Larval Malpighian Tubules    26.6 Larval Fat Body    38.5 Larval Salivary Gland    13.5 Larval Trachea  (1183.875) Larval Carcass    698.5 Adult Head    864.5 Adult Eye    256.625 Adult Brain    313.2 Adult Thoracic-Abdominal Ganglion    158.8 Adult Crop    73.9 Adult Midgut    196.2 Adult Hindgut    105.4 Adult Malpighian Tubules    26 Adult Fat Body    176.1 Adult Salivary Gland    76 Adult Heart  (2907.925) Adult VirginFemale Spermatheca    92.1 Adult InseminatedFemale Spermatheca    107 Adult Ovary    49.6 Adult Testis    93.2 Adult Male Accessory Gland    17 Adult Carcass  1036.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    28.6 Larval Midgut    130.7 Larval Hindgut    234.1 Larval Malpighian Tubules    26.6 Larval Fat Body    38.5 Larval Salivary Gland    13.5 Larval Trachea    1183.875 Larval Carcass    698.5 Adult Head    864.5 Adult Eye    256.625 Adult Brain    313.2 Adult Thoracic-Abdominal Ganglion    158.8 Adult Crop    73.9 Adult Midgut    196.2 Adult Hindgut    105.4 Adult Malpighian Tubules    26 Adult Fat Body    176.1 Adult Salivary Gland    76 Adult Heart    2907.925 Adult VirginFemale Spermatheca    92.1 Adult InseminatedFemale Spermatheca    107 Adult Ovary    49.6 Adult Testis    93.2 Adult Male Accessory Gland    17 Adult Carcass    1036.5 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    28.6 Larval Midgut    130.7 Larval Hindgut    234.1 Larval Malpighian Tubules    26.6 Larval Fat Body    38.5 Larval Salivary Gland    13.5 Larval Trachea    1183.875 Larval Carcass    698.5 Adult Head    864.5 Adult Eye    256.625 Adult Brain    313.2 Adult Thoracic-Abdominal Ganglion    158.8 Adult Crop    73.9 Adult Midgut    196.2 Adult Hindgut    105.4 Adult Malpighian Tubules    26 Adult Fat Body    176.1 Adult Salivary Gland    76 Adult Heart    2907.925 Adult VirginFemale Spermatheca    92.1 Adult InseminatedFemale Spermatheca    107 Adult Ovary    49.6 Adult Testis    93.2 Adult Male Accessory Gland    17 Adult Carcass    1036.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    28.6 Larval Midgut    130.7 Larval Hindgut    234.1 Larval Malpighian Tubules    26.6 Larval Fat Body    38.5 Larval Salivary Gland    13.5 Larval Trachea  (1183.875) Larval Carcass  698.5 Adult Head  (864.5) Adult Eye    256.625 Adult Brain    313.2 Adult Thoracic-Abdominal Ganglion    158.8 Adult Crop    73.9 Adult Midgut    196.2 Adult Hindgut    105.4 Adult Malpighian Tubules    26 Adult Fat Body    176.1 Adult Salivary Gland    76 Adult Heart  (2907.925) Adult VirginFemale Spermatheca    92.1 Adult InseminatedFemale Spermatheca    107 Adult Ovary    49.6 Adult Testis    93.2 Adult Male Accessory Gland    17 Adult Carcass  (1036.5) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    28.6 Larval Midgut    130.7 Larval Hindgut    234.1 Larval Malpighian Tubules    26.6 Larval Fat Body    38.5 Larval Salivary Gland    13.5 Larval Trachea  1183.875 Larval Carcass    698.5 Adult Head    864.5 Adult Eye    256.625 Adult Brain    313.2 Adult Thoracic-Abdominal Ganglion    158.8 Adult Crop    73.9 Adult Midgut    196.2 Adult Hindgut    105.4 Adult Malpighian Tubules    26 Adult Fat Body    176.1 Adult Salivary Gland    76 Adult Heart  (2907.925) Adult VirginFemale Spermatheca    92.1 Adult InseminatedFemale Spermatheca    107 Adult Ovary    49.6 Adult Testis    93.2 Adult Male Accessory Gland    17 Adult Carcass  1036.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    28.6 Larval Midgut    130.7 Larval Hindgut    234.1 Larval Malpighian Tubules    26.6 Larval Fat Body    38.5 Larval Salivary Gland    13.5 Larval Trachea    1183.875 Larval Carcass    698.5 Adult Head    864.5 Adult Eye    256.625 Adult Brain    313.2 Adult Thoracic-Abdominal Ganglion    158.8 Adult Crop    73.9 Adult Midgut    196.2 Adult Hindgut    105.4 Adult Malpighian Tubules    26 Adult Fat Body    176.1 Adult Salivary Gland    76 Adult Heart    2907.925 Adult VirginFemale Spermatheca    92.1 Adult InseminatedFemale Spermatheca    107 Adult Ovary    49.6 Adult Testis    93.2 Adult Male Accessory Gland    17 Adult Carcass    1036.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    864.5   NA  Eye    256.625   NA  Brain    313.2   28.6  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    158.8   NA  Crop    73.9   130.7  Midgut    196.2   234.1  Hindgut    105.4   26.6  Malpighian Tubules    26   38.5  Fat Body    176.1   13.5  Salivary Gland    76   NA  Heart    2907.925   1183.875  Trachea    NA   NA  VirginFemale Spermatheca    92.1   NA  InseminatedFemale Spermatheca    107   NA  Ovary    49.6   NA  Testis    93.2   NA  Male Accessory Gland    17   698.5  Carcass    1036.5 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    40 central nervous system, larvae L3    9 central nervous system, pupae P8    12 head, virgin 1-day female    47 head, virgin 4-day female    33 head, virgin 20-day female    46 head, mated 1-day female    33 head, mated 4-day female    44 head, mated 20-day female    47 head, mated 1-day male    33 head, mated 4-day male    44 head, mated 20-day male    54 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    12 digestive system, 4-day adult    7 digestive system, 20-day adult    3 fat body, larvae L3 wandering    1 fat body, white prepupae    10 fat body, pupae P8    38 carcass, larvae L3 wandering    38 carcass, 1-day adult    36 carcass, 4-day adult    24 carcass, 20-day adult    15 ovary, virgin 4-day female    2 ovary, mated 4-day female    1 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (40) central nervous system, larvae L3    9 central nervous system, pupae P8    12 head, virgin 1-day female  (47) head, virgin 4-day female  (33) head, virgin 20-day female  (46) head, mated 1-day female  (33) head, mated 4-day female  (44) head, mated 20-day female  (47) head, mated 1-day male  (33) head, mated 4-day male  (44) head, mated 20-day male  (54) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    12 digestive system, 4-day adult    7 digestive system, 20-day adult    3 fat body, larvae L3 wandering    1 fat body, white prepupae    10 fat body, pupae P8  (38) carcass, larvae L3 wandering  (38) carcass, 1-day adult  (36) carcass, 4-day adult    24 carcass, 20-day adult    15 ovary, virgin 4-day female    2 ovary, mated 4-day female    1 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    40 central nervous system, larvae L3    9 central nervous system, pupae P8    12 head, virgin 1-day female    47 head, virgin 4-day female    33 head, virgin 20-day female    46 head, mated 1-day female    33 head, mated 4-day female    44 head, mated 20-day female    47 head, mated 1-day male    33 head, mated 4-day male    44 head, mated 20-day male    54 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    12 digestive system, 4-day adult    7 digestive system, 20-day adult    3 fat body, larvae L3 wandering    1 fat body, white prepupae    10 fat body, pupae P8    38 carcass, larvae L3 wandering    38 carcass, 1-day adult    36 carcass, 4-day adult    24 carcass, 20-day adult    15 ovary, virgin 4-day female    2 ovary, mated 4-day female    1 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    40 central nervous system, larvae L3    9 central nervous system, pupae P8    12 head, virgin 1-day female    47 head, virgin 4-day female    33 head, virgin 20-day female    46 head, mated 1-day female    33 head, mated 4-day female    44 head, mated 20-day female    47 head, mated 1-day male    33 head, mated 4-day male    44 head, mated 20-day male    54 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    12 digestive system, 4-day adult    7 digestive system, 20-day adult    3 fat body, larvae L3 wandering    1 fat body, white prepupae    10 fat body, pupae P8    38 carcass, larvae L3 wandering    38 carcass, 1-day adult    36 carcass, 4-day adult    24 carcass, 20-day adult    15 ovary, virgin 4-day female    2 ovary, mated 4-day female    1 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    40 central nervous system, larvae L3    9 central nervous system, pupae P8    12 head, virgin 1-day female    47 head, virgin 4-day female    33 head, virgin 20-day female    46 head, mated 1-day female    33 head, mated 4-day female    44 head, mated 20-day female    47 head, mated 1-day male    33 head, mated 4-day male    44 head, mated 20-day male    54 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    12 digestive system, 4-day adult    7 digestive system, 20-day adult    3 fat body, larvae L3 wandering    1 fat body, white prepupae    10 fat body, pupae P8    38 carcass, larvae L3 wandering    38 carcass, 1-day adult    36 carcass, 4-day adult    24 carcass, 20-day adult    15 ovary, virgin 4-day female    2 ovary, mated 4-day female    1 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (40) central nervous system, larvae L3    9 central nervous system, pupae P8    12 head, virgin 1-day female  (47) head, virgin 4-day female  (33) head, virgin 20-day female  (46) head, mated 1-day female  (33) head, mated 4-day female  (44) head, mated 20-day female  (47) head, mated 1-day male  (33) head, mated 4-day male  (44) head, mated 20-day male  (54) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    12 digestive system, 4-day adult    7 digestive system, 20-day adult    3 fat body, larvae L3 wandering    1 fat body, white prepupae    10 fat body, pupae P8  (38) carcass, larvae L3 wandering  (38) carcass, 1-day adult  (36) carcass, 4-day adult    24 carcass, 20-day adult    15 ovary, virgin 4-day female    2 ovary, mated 4-day female    1 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    40 central nervous system, larvae L3    9 central nervous system, pupae P8    12 head, virgin 1-day female    47 head, virgin 4-day female    33 head, virgin 20-day female    46 head, mated 1-day female    33 head, mated 4-day female    44 head, mated 20-day female    47 head, mated 1-day male    33 head, mated 4-day male    44 head, mated 20-day male    54 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    12 digestive system, 4-day adult    7 digestive system, 20-day adult    3 fat body, larvae L3 wandering    1 fat body, white prepupae    10 fat body, pupae P8    38 carcass, larvae L3 wandering    38 carcass, 1-day adult    36 carcass, 4-day adult    24 carcass, 20-day adult    15 ovary, virgin 4-day female    2 ovary, mated 4-day female    1 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    40 central nervous system, larvae L3    9 central nervous system, pupae P8    12 head, virgin 1-day female    47 head, virgin 4-day female    33 head, virgin 20-day female    46 head, mated 1-day female    33 head, mated 4-day female    44 head, mated 20-day female    47 head, mated 1-day male    33 head, mated 4-day male    44 head, mated 20-day male    54 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    12 digestive system, 4-day adult    7 digestive system, 20-day adult    3 fat body, larvae L3 wandering    1 fat body, white prepupae    10 fat body, pupae P8    38 carcass, larvae L3 wandering    38 carcass, 1-day adult    36 carcass, 4-day adult    24 carcass, 20-day adult    15 ovary, virgin 4-day female    2 ovary, mated 4-day female    1 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed within 12-24 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    4 embryo 04-06hr    11 embryo 06-08hr    52 embryo 08-10hr    77 embryo 10-12hr    98 embryo 12-14hr    159 embryo 14-16hr    305 embryo 16-18hr    288 embryo 18-20hr    263 embryo 20-22hr    91 embryo 22-24hr    91 larva L1    97 larva L2    74 larva L3 12hr old    85 larva L3 puffstage 1-2    24 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    22 white prepupae new    29 white prepupae 12hr    18 white prepupae 24hr    29 pupae 2d postWPP    28 pupae 3d postWPP    48 pupae 4d postWPP    64 adult male 01day    26 adult male 05day    22 adult male 30day    15 adult female 01day    33 adult female 05day    10 adult female 30day    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    4 embryo 04-06hr    11 embryo 06-08hr  (52) embryo 08-10hr  (77) embryo 10-12hr  (98) embryo 12-14hr  (159) embryo 14-16hr  (305) embryo 16-18hr  (288) embryo 18-20hr  (263) embryo 20-22hr  (91) embryo 22-24hr  (91) larva L1  (97) larva L2  (74) larva L3 12hr old  (85) larva L3 puffstage 1-2    24 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    22 white prepupae new  (29) white prepupae 12hr    18 white prepupae 24hr  (29) pupae 2d postWPP  (28) pupae 3d postWPP  (48) pupae 4d postWPP  (64) adult male 01day  26 adult male 05day    22 adult male 30day    15 adult female 01day  (33) adult female 05day    10 adult female 30day    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    4 embryo 04-06hr    11 embryo 06-08hr    52 embryo 08-10hr    77 embryo 10-12hr    98 embryo 12-14hr  (159) embryo 14-16hr  (305) embryo 16-18hr  (288) embryo 18-20hr  (263) embryo 20-22hr    91 embryo 22-24hr    91 larva L1    97 larva L2    74 larva L3 12hr old    85 larva L3 puffstage 1-2    24 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    22 white prepupae new    29 white prepupae 12hr    18 white prepupae 24hr    29 pupae 2d postWPP    28 pupae 3d postWPP    48 pupae 4d postWPP    64 adult male 01day    26 adult male 05day    22 adult male 30day    15 adult female 01day    33 adult female 05day    10 adult female 30day    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    4 embryo 04-06hr    11 embryo 06-08hr    52 embryo 08-10hr    77 embryo 10-12hr    98 embryo 12-14hr    159 embryo 14-16hr    305 embryo 16-18hr    288 embryo 18-20hr    263 embryo 20-22hr    91 embryo 22-24hr    91 larva L1    97 larva L2    74 larva L3 12hr old    85 larva L3 puffstage 1-2    24 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    22 white prepupae new    29 white prepupae 12hr    18 white prepupae 24hr    29 pupae 2d postWPP    28 pupae 3d postWPP    48 pupae 4d postWPP    64 adult male 01day    26 adult male 05day    22 adult male 30day    15 adult female 01day    33 adult female 05day    10 adult female 30day    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    4 embryo 04-06hr    11 embryo 06-08hr    52 embryo 08-10hr    77 embryo 10-12hr    98 embryo 12-14hr    159 embryo 14-16hr    305 embryo 16-18hr    288 embryo 18-20hr    263 embryo 20-22hr    91 embryo 22-24hr    91 larva L1    97 larva L2    74 larva L3 12hr old    85 larva L3 puffstage 1-2    24 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    22 white prepupae new    29 white prepupae 12hr    18 white prepupae 24hr    29 pupae 2d postWPP    28 pupae 3d postWPP    48 pupae 4d postWPP    64 adult male 01day    26 adult male 05day    22 adult male 30day    15 adult female 01day    33 adult female 05day    10 adult female 30day    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    4 embryo 04-06hr    11 embryo 06-08hr  (52) embryo 08-10hr  (77) embryo 10-12hr  (98) embryo 12-14hr  (159) embryo 14-16hr  (305) embryo 16-18hr  (288) embryo 18-20hr  (263) embryo 20-22hr  (91) embryo 22-24hr  (91) larva L1  (97) larva L2  (74) larva L3 12hr old  (85) larva L3 puffstage 1-2    24 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    22 white prepupae new  29 white prepupae 12hr    18 white prepupae 24hr  29 pupae 2d postWPP  28 pupae 3d postWPP  (48) pupae 4d postWPP  (64) adult male 01day  26 adult male 05day    22 adult male 30day    15 adult female 01day  (33) adult female 05day    10 adult female 30day    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    4 embryo 04-06hr    11 embryo 06-08hr    52 embryo 08-10hr    77 embryo 10-12hr    98 embryo 12-14hr  (159) embryo 14-16hr  (305) embryo 16-18hr  (288) embryo 18-20hr  (263) embryo 20-22hr    91 embryo 22-24hr    91 larva L1    97 larva L2    74 larva L3 12hr old    85 larva L3 puffstage 1-2    24 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    22 white prepupae new    29 white prepupae 12hr    18 white prepupae 24hr    29 pupae 2d postWPP    28 pupae 3d postWPP    48 pupae 4d postWPP    64 adult male 01day    26 adult male 05day    22 adult male 30day    15 adult female 01day    33 adult female 05day    10 adult female 30day    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    4 embryo 04-06hr    11 embryo 06-08hr    52 embryo 08-10hr    77 embryo 10-12hr    98 embryo 12-14hr    159 embryo 14-16hr    305 embryo 16-18hr    288 embryo 18-20hr    263 embryo 20-22hr    91 embryo 22-24hr    91 larva L1    97 larva L2    74 larva L3 12hr old    85 larva L3 puffstage 1-2    24 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    22 white prepupae new    29 white prepupae 12hr    18 white prepupae 24hr    29 pupae 2d postWPP    28 pupae 3d postWPP    48 pupae 4d postWPP    64 adult male 01day    26 adult male 05day    22 adult male 30day    15 adult female 01day    33 adult female 05day    10 adult female 30day    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    6 Schneider line 2 Sg4    253 embryonic 1182-4H    85 embryonic GM2    57 embryonic Kc167    5 embryonic S1    122 embryonic S3    230 leg disc CME L1    431 wing disc CME-W2    346 wing disc ML-DmD8    5 wing disc ML-DmD9    1153 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    4 wing disc ML-DmD32    5014 haltere disc ML-DmD17-c3    5 eye-antennal disc ML-DmD11    863 antennal disc ML-DmD20-c5    593 mixed discs ML-DmD4-c1    292 CNS ML-DmBG1-c1    66 CNS ML-DmBG2-c2    71 tumorous blood cells mbn2    25 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    6 Schneider line 2 Sg4  (253) embryonic 1182-4H  (85) embryonic GM2  (57) embryonic Kc167    5 embryonic S1  (122) embryonic S3  (230) leg disc CME L1  (431) wing disc CME-W2  (346) wing disc ML-DmD8    5 wing disc ML-DmD9  (1153) wing disc ML-DmD16-c3    11 wing disc ML-DmD21    4 wing disc ML-DmD32  (5014) haltere disc ML-DmD17-c3    5 eye-antennal disc ML-DmD11  (863) antennal disc ML-DmD20-c5  (593) mixed discs ML-DmD4-c1  (292) CNS ML-DmBG1-c1  (66) CNS ML-DmBG2-c2  (71) tumorous blood cells mbn2    25 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    6 Schneider line 2 Sg4  (253) embryonic 1182-4H    85 embryonic GM2    57 embryonic Kc167    5 embryonic S1  (122) embryonic S3  (230) leg disc CME L1  (431) wing disc CME-W2  (346) wing disc ML-DmD8    5 wing disc ML-DmD9  (1153) wing disc ML-DmD16-c3    11 wing disc ML-DmD21    4 wing disc ML-DmD32  (5014) haltere disc ML-DmD17-c3    5 eye-antennal disc ML-DmD11  (863) antennal disc ML-DmD20-c5  (593) mixed discs ML-DmD4-c1  (292) CNS ML-DmBG1-c1    66 CNS ML-DmBG2-c2    71 tumorous blood cells mbn2    25 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    6 Schneider line 2 Sg4    253 embryonic 1182-4H    85 embryonic GM2    57 embryonic Kc167    5 embryonic S1    122 embryonic S3    230 leg disc CME L1    431 wing disc CME-W2    346 wing disc ML-DmD8    5 wing disc ML-DmD9    1153 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    4 wing disc ML-DmD32    5014 haltere disc ML-DmD17-c3    5 eye-antennal disc ML-DmD11    863 antennal disc ML-DmD20-c5    593 mixed discs ML-DmD4-c1    292 CNS ML-DmBG1-c1    66 CNS ML-DmBG2-c2    71 tumorous blood cells mbn2    25 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    6 Schneider line 2 Sg4    253 embryonic 1182-4H    85 embryonic GM2    57 embryonic Kc167    5 embryonic S1    122 embryonic S3    230 leg disc CME L1    431 wing disc CME-W2    346 wing disc ML-DmD8    5 wing disc ML-DmD9    1153 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    4 wing disc ML-DmD32    5014 haltere disc ML-DmD17-c3    5 eye-antennal disc ML-DmD11    863 antennal disc ML-DmD20-c5    593 mixed discs ML-DmD4-c1    292 CNS ML-DmBG1-c1    66 CNS ML-DmBG2-c2    71 tumorous blood cells mbn2    25 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    6 Schneider line 2 Sg4  (253) embryonic 1182-4H  (85) embryonic GM2  (57) embryonic Kc167    5 embryonic S1  (122) embryonic S3  (230) leg disc CME L1  (431) wing disc CME-W2  (346) wing disc ML-DmD8    5 wing disc ML-DmD9  (1153) wing disc ML-DmD16-c3    11 wing disc ML-DmD21    4 wing disc ML-DmD32  (5014) haltere disc ML-DmD17-c3    5 eye-antennal disc ML-DmD11  (863) antennal disc ML-DmD20-c5  (593) mixed discs ML-DmD4-c1  (292) CNS ML-DmBG1-c1  (66) CNS ML-DmBG2-c2  (71) tumorous blood cells mbn2    25 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    6 Schneider line 2 Sg4  (253) embryonic 1182-4H    85 embryonic GM2    57 embryonic Kc167    5 embryonic S1  122 embryonic S3  (230) leg disc CME L1  (431) wing disc CME-W2  (346) wing disc ML-DmD8    5 wing disc ML-DmD9  (1153) wing disc ML-DmD16-c3    11 wing disc ML-DmD21    4 wing disc ML-DmD32  (5014) haltere disc ML-DmD17-c3    5 eye-antennal disc ML-DmD11  (863) antennal disc ML-DmD20-c5  (593) mixed discs ML-DmD4-c1  (292) CNS ML-DmBG1-c1    66 CNS ML-DmBG2-c2    71 tumorous blood cells mbn2    25 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    6 Schneider line 2 Sg4    253 embryonic 1182-4H    85 embryonic GM2    57 embryonic Kc167    5 embryonic S1    122 embryonic S3    230 leg disc CME L1    431 wing disc CME-W2    346 wing disc ML-DmD8    5 wing disc ML-DmD9    1153 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    4 wing disc ML-DmD32    5014 haltere disc ML-DmD17-c3    5 eye-antennal disc ML-DmD11    863 antennal disc ML-DmD20-c5    593 mixed discs ML-DmD4-c1    292 CNS ML-DmBG1-c1    66 CNS ML-DmBG2-c2    71 tumorous blood cells mbn2    25 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    6 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    18 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    5 Ethanol 5% 3 hrs, larvae L3    17 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    6 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    18 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    5 Ethanol 5% 3 hrs, larvae L3    17 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    6 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    18 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    5 Ethanol 5% 3 hrs, larvae L3    17 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    6 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    18 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    5 Ethanol 5% 3 hrs, larvae L3    17 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    6 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    18 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    5 Ethanol 5% 3 hrs, larvae L3    17 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    6 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    18 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    5 Ethanol 5% 3 hrs, larvae L3    17 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    6 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    18 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    5 Ethanol 5% 3 hrs, larvae L3    17 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    6 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    18 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    5 Ethanol 5% 3 hrs, larvae L3    17 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_29
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003137 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG33103-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage | recessive, with Scer\GAL4Act5C.PI PpnScer\UAS.cKa lethal | embryonic stage | recessive, with Scer\GAL4da.G32 PpnScer\UAS.cKa lethal | pupal stage, with Scer\GAL4pnr-MD237 PpnGD6325 Phenotype manifest in Allele embryonic/larval somatic muscle PpndsRNA.cKa embryonic/larval somatic muscle, with Scer\GAL4Act5C.PI PpnScer\UAS.cKa embryonic/larval somatic muscle, with Scer\GAL4da.G32 PpnScer\UAS.cKa embryonic/larval tracheal system, with Scer\GAL4Act5C.PI PpnScer\UAS.cKa embryonic/larval tracheal system, with Scer\GAL4da.G32 PpnScer\UAS.cKa Malpighian tubule, with Scer\GAL4Act5C.PI PpnScer\UAS.cKa Malpighian tubule, with Scer\GAL4da.G32 PpnScer\UAS.cKa
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of Ppn Class Mutagen Stocks Known lesion PpnG4259 P-element activity 1 -- PpnMB07666 1 -- PpnMI03189 1 --
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Ppn Class Mutagen Stocks Known lesion PpnGD6325 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes PpnKK101228 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Ppna.Scer\UAS in vitro construct - regulatory fusion 0 Yes PpndsRNA.cKa in vitro construct - RNAi 0 Yes PpnNIG.1540R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes PpnScer\UAS.cKa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6259 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD6325} NA P{KK101228} NA P{NIG.1540R} NA P{UAS-Ppn.anti.K} NA P{UAS-Ppn.K} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap binary system Mi{ET1}PpnMB07666 No insertion of mobile activating element P{EP}PpnG4259 NA miscellaneous insertions Mi{MIC}PpnMI03189 NA
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function
CV term Evidence References
extracellular matrix structural constituent inferred from mutant phenotype (assigned by UniProtKB) (Kramerova et al., 2000)
Biological Process
CV term Evidence References
extracellular matrix organization inferred from mutant phenotype (assigned by UniProtKB) (Kramerova et al., 2000)
Cellular Component
CV term Evidence References
basement membrane inferred from direct assay (Campbell et al., 1987) inferred from direct assay (assigned by UniProtKB) (Kramerova et al., 2000)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
metalloendopeptidase activity inferred from electronic annotation with InterPro:IPR010294 (FlyBase Curators et al., 2004-) serine-type endopeptidase inhibitor activity inferred from electronic annotation with InterPro:IPR002223 (FlyBase Curators et al., 2004-) zinc ion binding inferred from electronic annotation with InterPro:IPR013273 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
proteinaceous extracellular matrix non-traceable author statement (Robertson, 2000.4.15, Kramerova, 1999.11.15)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Ppn allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68683 DroID - A comprehensive database of gene and protein interactions. • FBgn0003137 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43872
Orthologs
OrthoDB Orthologs (46) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG69GM1W Dipteran inclusive ortholog search EOG6FR10H Insect inclusive ortholog search EOG6RXWV0 Arthropod inclusive ortholog search EOG6ZCRK8 Metazoa inclusive ortholog search EOG64FK2R
Orthologs in Drosophila Species (EOG69GM1W)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Ppn     Drosophila simulans   Dsim\GD18032 Y   Drosophila sechellia   Dsec\GM16292 Y   Drosophila sechellia   Dsec\GM11554     Drosophila erecta   Dere\GG12068 Y   Drosophila yakuba   Dyak\GE10512 Y   Drosophila ananassae   Dana\GF16440 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA22193     Drosophila pseudoobscura pseudoobscura   Dpse\GA17283 Y   Drosophila persimilis   Dper\GL23094 Y   Drosophila willistoni   Dwil\GK10999 Y   Drosophila virilis   Dvir\GJ14166 Y   Drosophila virilis   Dvir\GJ18383     Drosophila mojavensis   Dmoj\GI22868 Y   Drosophila grimshawi   Dgri\GH18720 Y
Orthologs in non-Drosophila Dipterans (EOG6FR10H)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL009795   Anopheles gambiae Malaria mosquito  Agam\AGAP001662   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ001828
Orthologs in non-Dipteran Insects (EOG6RXWV0)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB46795   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG011720   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH15492   Atta cephalotes Leafcutter ant  Acep\ACEP17693   Atta cephalotes Leafcutter ant  Acep\ACEP23440   Atta cephalotes Leafcutter ant  Acep\ACEP17694   Atta cephalotes Leafcutter ant  Acep\ACEP17692   Camponotus floridanus Florida carpenter ant  Cflo\CFLO18827   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL15127   Linepithema humile Argentine ant  Lhum\LH14153   Linepithema humile Argentine ant  Lhum\LH14152   Pogonomyrmex barbatus Red harvester ant  Pbar\PB22142   Pogonomyrmex barbatus Red harvester ant  Pbar\PB22143   Pogonomyrmex barbatus Red harvester ant  Pbar\PB26969   Solenopsis invicta Red fire ant  Sinv\SINV22205   Solenopsis invicta Red fire ant  Sinv\SINV18368   Acyrthosiphon pisum Pea aphid  Apim\ACYPI003244   Bombyx mori Silkmoth  Bmor\BGIBMGA005129   Bombyx mori Silkmoth  Bmor\BGIBMGA005130   Pediculus humanus Human body louse  Phum\PHUM547410   Tribolium castaneum Red flour beetle  Tcas\TC010195
Orthologs in non-Insect Arthropods (EOG6ZCRK8)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_314628   Ixodes scapularis Deer tick  Isca\ISCW003862
Orthologs in non-Arthropod Metazoa (EOG64FK2R)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\C37C3.6   Caenorhabditis elegans Nematode  Cele\Y43F8B.3   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_023903gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_002031gn   Danio rerio Zebrafish  Drer\tfpia
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD18032 Drosophila sechellia Dsec\GM16292 Drosophila erecta Dere\GG12068 Drosophila yakuba Dyak\GE10512 Drosophila ananassae Dana\GF16440 Drosophila pseudoobscura pseudoobscura Dpse\GA17283 Drosophila persimilis Dper\GL23094 Drosophila willistoni Dwil\GK10999 Drosophila virilis Dvir\GJ14166 Drosophila mojavensis Dmoj\GI22868 Drosophila grimshawi Dgri\GH18720
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	25277 w1118; Mi{ET1}PpnMB07666 31782 w1118; P{EP}PpnG4259/TM6C, Sb1 36216 y1 w*; Mi{MIC}PpnMI03189/TM3, Sb1 Ser1
VDRC	v108005 P{KK101228}VIE-260B v16523 w1118; P{GD6325}v16523
Genomic Clones ( 1 )
	BACR09F18 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 57 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH05059 LD02520
Other clones	GH25513 MIP27932
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH11075 GM10557 GM12874 GM15186 GM25024 LP11693
Other clones	6004 28723 30121 38990 44816 54665 65130 71697 72461 75499 78019 80628 106482 159944 182906 194493 214251.2 CK01.19C.F9 CK01.28B.D4 CK01.52A.H7 CK01.82D.D8 CK01.85A.E5 CK01.95B.G7 CK01.115D.F2 CK01.146D.D8 EC251950 EC254724 EC257544 EK018521 EK042232 EK066148 EK120548 EK124816 EK152013 EK179860 EK191421 EK199743 EK201161 EK205246 EK210604 EK213720 EK230804 EK231942 EK286836 EP12264 EP21115 EP22116
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0003137 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43872
Antibody Information
	polyclonal (Gullberg et al., 1994)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: lacunin CG1540 (Hynes and Zhao, 2000)
Source for database merge of	Source for merge of: CG1540 CG18436 (Whitfield, 2000.10.31) Source for merge of: Ppn lacunin (Kramerova et al., 2000)
Additional comments	Annotation CG1540 split into CG31051 and CG33103 (Ppn) in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) Relationship of "Mdp-1" with "Ppn" is unclear; mAb 5H7 recognises "Mdp-1" protein in embryo protein extracts, and "Ppn" in Kc cell protein extracts. However biochemical analysis of the two proteins reveals a number of significant differences between the two molecules. "Ppn" and "Mdp-1" may therefore represent two different genes, or "Mdp-1" protein may be the naturally occurring form of "Ppn", which is secreted by Kc cells in culture. (Hortsch et al., 1998)
Other Comments
	The Ppn gene product influences cell rearrangements and may modulate metalloproteinases during organogenesis. (Kramerova et al., 2000) Ppn protein, a sulfated glycoprotein, has been isolated from the culture media of Drosophila Kc cells, and its expression in embryos and larvae has been studied. (Campbell et al., 1987)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_176574 NM_176575 NM_001170289 NM_001170290 RefSeq (Proteins) • NP_788751 NP_788752 NP_001163760 NP_001163761 DDBJ / EMBL / GenBank • AA202349 AAF56794 AAF56795 AAG37995 AAL28183 AAO84907 AAO84908 ACZ95054 ACZ95055 AF205357 AF529179 AF529180 AI064596 AW940188 AY060635 Entrez Gene - A searchable database of RefSeq genes. • 43872 UniProtKB/Swiss-Prot • Q868Z9 UniProtKB/TrEMBL • Q95SR4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Thrombospondin, type 1 repeat (IPR000884) Proteinase inhibitor I2, Kunitz metazoa (IPR002223) Immunoglobulin subtype 2 (IPR003598) Immunoglobulin-like domain (IPR007110) Whey acidic protein-type 4-disulphide core (IPR008197) ADAM-TS Spacer 1 (IPR010294) PLAC (IPR010909) Peptidase M12B, ADAM-TS (IPR013273) Immunoglobulin-like fold (IPR013783) Proteinase inhibitor I2, Kunitz, conserved site (IPR020901) Immunoglobulin I-set (IPR013098)
Linkouts
	BioGRID - A database of protein and genetic interactions • 68683 DroID - A comprehensive database of gene and protein interactions. • FBgn0003137 DRSC - Results from RNAi screens. • FBgn0003137 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003137 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG33103-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0003137 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43872 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43872 modMine - Data generated by the modENCODE project. • FBgn0003137
Synonyms & Secondary IDs ( 12 )
Reported As
Symbol Synonym	CG1540   CG18436 (Whitfield, 2000.10.31, ) CG33103 (Fakhouri et al., 2006, Keleman et al., 2009.8.5, Cammarato et al., 2011) CT3186 (Hynes and Zhao, 2000) CT41988 (Hynes and Zhao, 2000) ppl (Kramerova et al., 1998) Ppn (Kallappagoudar et al., 2010, Firth and Baker, 2007, Kwon et al., 2008, Liu et al., 2009, Leatherbarrow and Halfon, 2009, Wasbrough et al., 2010, Khodor et al., 2011, Japanese National Institute of Genetics, 2012.5.21) ppn (Leatherbarrow and Halfon, 2009, Firth and Baker, 2007)
Name Synonym	lacunin (Robertson, 2000.4.15, ) lacunin-like (Hynes and Zhao, 2000) papilin (Kramerov and Fessler, 2001, Kramerova, 1999.11.15, Campbell et al., 1987, Kramerova et al., 2003, Gullberg et al., 1994, Firth and Baker, 2007) Papilin (Brown et al., 2000, Fakhouri et al., 2006, Yasuhara and Wakimoto, 2008, Yoshida et al., 2008, Cammarato et al., 2011, Felix et al., 2012, Meyer et al., 2011)
Secondary FlyBase IDs
	FBgn0039586 FBgn0039587 FBgn0053103
References ( 52 )
Generate a list of	All references relating to this gene ( 52 )
List References by type	Research paper  ( 20 ) Supplementary material  ( 6 ) Review  ( 4 ) Personal communication to FlyBase  ( 10 ) Abstract  ( 6 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Stock list  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 4 )
	Felix et al., 2012, Genetics 191(3): 989--1002 Age-Specific Variation in Immune Response in Drosophila melanogaster Has a Genetic Basis. [FBrf0218944] Krauchunas et al., 2012, Dev. Biol. 370(1): 125--134 Protein phosphorylation changes reveal new candidates in the regulation of egg activation and early embryogenesis in D. melanogaster. [FBrf0219342] Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784 GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834] Khodor et al., 2011, Genes Dev. 25(23): 2502--2512 Nascent-seq indicates widespread cotranscriptional pre-mRNA splicing in Drosophila. [FBrf0216892] Show all research papers ...
Recent reviews ( 2 )
	Broadie et al., 2011, Dev. Neurobiol. 71(11): 1102--1130 Extracellular matrix and its receptors in drosophila neural development. [FBrf0216377] Meyer et al., 2011, Europ. J. Cell Biol. 90(9): 770--778 Drosophila metalloproteases in development and differentiation: The role of ADAM proteins and their relatives. [FBrf0214506] Show all reviews ...