• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • RNA-Seq Search
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • GBrowse 2 Beta
    • CytoSearch
    • Feature Mapper
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Current release
  • Archived releases
  • Map Conversion
  • FTP site:
  • Releases (FTP)
  • Genomes (FTP)
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Vectors & Constructs
  • Other links:
  • BDGP
  • DGRC
  • DIS by issue
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\Ptp61F

General Information
Symbol	Dmel\Ptp61F	Species	D. melanogaster
Name	Protein tyrosine phosphatase 61F	Annotation symbol	CG9181
Feature type	protein_coding_gene	FlyBase ID	FBgn0003138
Gene Model Status	Current	Stock availability	30 publicly available
Also Known As	DPTP61F
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	61F7-62A2	Sequence location	3L:1,342,493..1,475,249 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Protein tyrosine phosphatase 61F is referred to in FlyBase by the symbol Dmel\Ptp61F (CG9181, FBgn0003138). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein tyrosine phosphatase activity; protein binding. There is experimental evidence that it is involved in the biological process: mitotic cell cycle; negative regulation of peptidyl-tyrosine phosphorylation; regulation of protein stability; protein dephosphorylation; axon guidance; negative regulation of JAK-STAT cascade; germ-band extension; cellular response to hypoxia; oogenesis; regulation of protein localization. 43 alleles are reported. No phenotypic data is available. It has 5 annotated transcripts and 5 annotated polypeptides. Protein features are: Protein-tyrosine phosphatase, active site; Protein-tyrosine phosphatase, receptor/non-receptor type; Protein-tyrosine/Dual specificity phosphatase. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult female reproductive system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval Malpighian tubules, adult heart, larval/adult salivary gland, larval trachea, inseminated spermatheca, adult male reproductive system, larval carcass. Gene sequence location is 3L:1342493..1475249.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 61F7-62A2   Limits computationally determined from genome sequence between P{PZ}l(3)0264002640 and P{EP}rhoEP3704&P{PZ}l(3)0622606226
Experimentally Determined Cytological Location
Cytogenetic map Notes References 61F-61F     (McLaughlin, 1993.5.19) 61F-61F   (determined by in situ hybridisation)   (McLaughlin and Dixon, 1993)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Ptp61F for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.42 Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Ptp61F-RA FBtr0072718  NM_057339   2181   548 Ptp61F-RB FBtr0072717  NM_057340   1901   535 Ptp61F-RC FBtr0072716  NM_167874   1796   530 Ptp61F-RD FBtr0072719  NM_167875   2606   431 Ptp61F-RE FBtr0310161  NM_001274324   5159   431
Additional Transcript Data & Comments
Reported size (kB)	2.8, 2.0 (northern blot) (McLaughlin and Dixon, 1993)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Ptp61F-PA   FBpp0072602   62.1   548   5.24     NP_476687   AAF47487 Ptp61F-PB   FBpp0072601   61.0   535   5.76     NP_476688   AAF47486 Ptp61F-PC   FBpp0072600   60.5   530   5.90     NP_728600   AAN11475 Ptp61F-PD   FBpp0072603   48.5   431   4.81     NP_728601   AAN11476 Ptp61F-PE   FBpp0301846   48.5   431   4.81     NP_001261253   AGB93948
Additional Polypeptide Data & Comments
Reported size (kDa)	548, 535 (aa); 62, 61 (kD) (McLaughlin and Dixon, 1993) 72 (kD observed) (Clemens et al., 1996)
Comments	In vitro and in vivo interaction between Ptp61F and dock proteins were demonstrated. One or more of the SH3 domains of dock protein likely mediate the interaction with a region of the Ptp61F protein containing five PXXP-motifs (where X represents any amino acid). (Clemens et al., 1996) The Ptp61F proteins are 33-34% identical overall to other protein tyrosine phosphatases and 50% identical in the catalytic domain. Ptp61F proteins expressed as fusions with glutathione S-tranferase were shown to have tyrosine phosphatase activity. The carboxy terminal sequences were implicated in targeting of the two protein forms to either the cytoplasm or the nucleus. (McLaughlin and Dixon, 1993) The Ptp61F proteins are 33-34% identical overall to other protein tyrosine phosphatases and 50% identical in the catalytic domain. Ptp61F proteins expressed as fusions with glutathione S-tranferase were shown to have tyrosine phosphatase activity. The carboxy terminal sequences were implicated in targeting of the two protein forms to either the cytoplasm or nucleus. (McLaughlin and Dixon, 1993)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein-tyrosine phosphatase, receptor/non-receptor type (IPR000242) Protein-tyrosine/Dual specificity phosphatase (IPR000387) Protein-tyrosine phosphatase, active site (IPR016130)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA264705   AA391989   AA439309   AA441223   AA441619   AA567352   AA567483   AA567617   AA804005   AA817304   AA820650   AA940671   AA940674   AA942616   AA950581   AA950583   AA950979   AA978591   AE014296 AAF47486   AE014296 AAF47487   AE014296 AAN11475   AE014296 AAN11476   AC004489   AC005847   AE014296 AGB93948   AI061941   AI258156   AI260592   AI406028   AI456987   AI511881   AI511944   AI512270   AI512560   AI512887   AI514643   AI515068   AI515078   AI515088   AI515089   AI515388   AI515589   AI518056   AI518271   AI518550   AI519924   AI531311   AI532011   AI532045   AI533354   AI533532   AI544084   AI544225   AI544237   AW943967   AX094173   AX154749   AY060968   AY069713 AAL39858   BF486201   BF486545   BF491423   BF496522   BF499467   BF499471   BF502951   BF503310   BG632364   BG635400   BG636075   BG636137   BG639746   BG641229   BI161905   BI161906   BI162187   BI162188   BI163818   BI164333   BI165045   BI165068   BI167349   BI168058   BI170889   BI172336   BI172453   BI172763   BI173047   BI214014   BI214203   BI215454   BI215689   BI215764   BI228159   BI228165   BI228498   BI230904   BI234714   BI235150   BI236747   BI237519   BI238028   BI238429   BI239646   BI239723   BI239899   BI240453   BI241394   BI241471   BI242746   BI243029   BI243062   BI356116   BI358158   BI361808   BI361910   BI362366   BI363532   BI364399   BI364515   BI365692   BI365986   BI372026   BI372047   BI372058   BI373138   BI373720   BI374645   BI375819   BI481743   BI481877   BI482950   BI483118   BI483544   BI483585   BI485218   BI485521   BI486304   BI486439   BI564872   BI565814   BI566006   BI569870   BI571025   BI572498   BI577215   BI577815   BI578441   BI579259   BI579335   BI579409   BI579461   BI580157   BI580246   BI580496   BI580686   BI591096   BI591131   BI607529   BI610151   BI611641   BI613041   BI613867   BI621401   BI624920   BI625936   BI628789   BI631700   BI641774   BP549370   BT056312   BT120050   BT133407   CA807003   CO153177   CO188737   CO190360   CO266469   CO281967   CO285819   CO292015   CO300155   CO304076   CO311640   CO313893   CO316057   CO317152   CO319568   CO320177   CO320686   CO326072   CO326700   CO328047   CO330914   CZ466343   CZ469851   CZ470193   CZ470300   CZ475944   CZ476005   CZ478262   CZ479087   CZ482995   CZ489663   CZ489664   DU708629   EC052157   EC052646   EC052647   EC053146   EC053147   EC054824   EC055680   EC056092   EC056402   EC067530   EC071976   EC073489   EC074348   EC076674   EC089357   EC090008   EC202309   EC206956   EC210307   EC211562   EC216086   EC229687   EC238608   EC239021   EC239161   EC246866   EC246954   EC248102   EC255279   EC265420   EL871199   EV587018   EV590762   GH739273   GH945731   GH946178   GH946813   GH949267   GH952656   GH954124   GH956663   GH957106   GH958179   GH959268   GH959284   GH959477   GH961366   GH964040   GH964697   GH969490   GH971423   GH973313   GH975715   GH976181   GH976949   GH977482   GH978621   GH978731   GH979243   GH982657   GH982863   GH982923   L11249   L11250 AAA75348   L11251 AAA75349   L11252 AAA75338   L11253 AAA75339   L14849 AAA28748
UniProtKB/Swiss-Prot	Q9W0G1
UniProtKB/TrEMBL	Q8IRH4
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage & pupal stage & adult stage     (Clemens et al., 1996) embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012) embryonic stage 9 -- 10   central brain primordium   (Fisher et al., 2012) clypeo-labral primordium   (Fisher et al., 2012) foregut primordium   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral ectoderm   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 11 -- 12   central brain primordium   (Fisher et al., 2012) clypeo-labral primordium   (Fisher et al., 2012) Malpighian tubule primordium   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 14   presumptive embryonic/larval central nervous system   (Clemens et al., 1996)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
	The 535aa form of Ptp61F localizes to the nucleus when expressed in COS cells. (McLaughlin and Dixon, 1993) The 548aa form of Ptp61F protein localizes to a "reticular" network as well as to mitochondria-like organelles when expressed in COS cells. (McLaughlin and Dixon, 1993)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
cytoplasm inferred from direct assay (McLaughlin and Dixon, 1993) nucleus inferred from direct assay (McLaughlin and Dixon, 1993) perinuclear region of cytoplasm inferred from direct assay (Huang et al., 2007)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult female reproductive system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval Malpighian tubules, adult heart, larval/adult salivary gland, larval trachea, inseminated spermatheca, adult male reproductive system, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    46 central nervous system, larvae L3    54 central nervous system, pupae P8    26 head, virgin 1-day female    15 head, virgin 4-day female    15 head, virgin 20-day female    9 head, mated 1-day female    16 head, mated 4-day female    12 head, mated 20-day female    10 head, mated 1-day male    19 head, mated 4-day male    21 head, mated 20-day male    20 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    15 digestive system, larvae L3 wandering    23 digestive system, 1-day adult    11 digestive system, 4-day adult    15 digestive system, 20-day adult    14 fat body, larvae L3 wandering    6 fat body, white prepupae    13 fat body, pupae P8    10 carcass, larvae L3 wandering    30 carcass, 1-day adult    10 carcass, 4-day adult    13 carcass, 20-day adult    13 ovary, virgin 4-day female    89 ovary, mated 4-day female    85 testis, mated 4-day male    49 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (46) central nervous system, larvae L3  (54) central nervous system, pupae P8  26 head, virgin 1-day female    15 head, virgin 4-day female    15 head, virgin 20-day female    9 head, mated 1-day female    16 head, mated 4-day female    12 head, mated 20-day female    10 head, mated 1-day male    19 head, mated 4-day male    21 head, mated 20-day male    20 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    15 digestive system, larvae L3 wandering    23 digestive system, 1-day adult    11 digestive system, 4-day adult    15 digestive system, 20-day adult    14 fat body, larvae L3 wandering    6 fat body, white prepupae    13 fat body, pupae P8    10 carcass, larvae L3 wandering  (30) carcass, 1-day adult    10 carcass, 4-day adult    13 carcass, 20-day adult    13 ovary, virgin 4-day female  (89) ovary, mated 4-day female  (85) testis, mated 4-day male  (49) accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    46 central nervous system, larvae L3    54 central nervous system, pupae P8    26 head, virgin 1-day female    15 head, virgin 4-day female    15 head, virgin 20-day female    9 head, mated 1-day female    16 head, mated 4-day female    12 head, mated 20-day female    10 head, mated 1-day male    19 head, mated 4-day male    21 head, mated 20-day male    20 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    15 digestive system, larvae L3 wandering    23 digestive system, 1-day adult    11 digestive system, 4-day adult    15 digestive system, 20-day adult    14 fat body, larvae L3 wandering    6 fat body, white prepupae    13 fat body, pupae P8    10 carcass, larvae L3 wandering    30 carcass, 1-day adult    10 carcass, 4-day adult    13 carcass, 20-day adult    13 ovary, virgin 4-day female    89 ovary, mated 4-day female    85 testis, mated 4-day male    49 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    46 central nervous system, larvae L3    54 central nervous system, pupae P8    26 head, virgin 1-day female    15 head, virgin 4-day female    15 head, virgin 20-day female    9 head, mated 1-day female    16 head, mated 4-day female    12 head, mated 20-day female    10 head, mated 1-day male    19 head, mated 4-day male    21 head, mated 20-day male    20 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    15 digestive system, larvae L3 wandering    23 digestive system, 1-day adult    11 digestive system, 4-day adult    15 digestive system, 20-day adult    14 fat body, larvae L3 wandering    6 fat body, white prepupae    13 fat body, pupae P8    10 carcass, larvae L3 wandering    30 carcass, 1-day adult    10 carcass, 4-day adult    13 carcass, 20-day adult    13 ovary, virgin 4-day female    89 ovary, mated 4-day female    85 testis, mated 4-day male    49 accessory gland, mated 4-day male    11 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    46 central nervous system, larvae L3    54 central nervous system, pupae P8    26 head, virgin 1-day female    15 head, virgin 4-day female    15 head, virgin 20-day female    9 head, mated 1-day female    16 head, mated 4-day female    12 head, mated 20-day female    10 head, mated 1-day male    19 head, mated 4-day male    21 head, mated 20-day male    20 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    15 digestive system, larvae L3 wandering    23 digestive system, 1-day adult    11 digestive system, 4-day adult    15 digestive system, 20-day adult    14 fat body, larvae L3 wandering    6 fat body, white prepupae    13 fat body, pupae P8    10 carcass, larvae L3 wandering    30 carcass, 1-day adult    10 carcass, 4-day adult    13 carcass, 20-day adult    13 ovary, virgin 4-day female    89 ovary, mated 4-day female    85 testis, mated 4-day male    49 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (46) central nervous system, larvae L3  (54) central nervous system, pupae P8  26 head, virgin 1-day female    15 head, virgin 4-day female    15 head, virgin 20-day female    9 head, mated 1-day female    16 head, mated 4-day female    12 head, mated 20-day female    10 head, mated 1-day male    19 head, mated 4-day male    21 head, mated 20-day male    20 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    15 digestive system, larvae L3 wandering    23 digestive system, 1-day adult    11 digestive system, 4-day adult    15 digestive system, 20-day adult    14 fat body, larvae L3 wandering    6 fat body, white prepupae    13 fat body, pupae P8    10 carcass, larvae L3 wandering  30 carcass, 1-day adult    10 carcass, 4-day adult    13 carcass, 20-day adult    13 ovary, virgin 4-day female  (89) ovary, mated 4-day female  (85) testis, mated 4-day male  (49) accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    46 central nervous system, larvae L3    54 central nervous system, pupae P8    26 head, virgin 1-day female    15 head, virgin 4-day female    15 head, virgin 20-day female    9 head, mated 1-day female    16 head, mated 4-day female    12 head, mated 20-day female    10 head, mated 1-day male    19 head, mated 4-day male    21 head, mated 20-day male    20 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    15 digestive system, larvae L3 wandering    23 digestive system, 1-day adult    11 digestive system, 4-day adult    15 digestive system, 20-day adult    14 fat body, larvae L3 wandering    6 fat body, white prepupae    13 fat body, pupae P8    10 carcass, larvae L3 wandering    30 carcass, 1-day adult    10 carcass, 4-day adult    13 carcass, 20-day adult    13 ovary, virgin 4-day female    89 ovary, mated 4-day female    85 testis, mated 4-day male    49 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    46 central nervous system, larvae L3    54 central nervous system, pupae P8    26 head, virgin 1-day female    15 head, virgin 4-day female    15 head, virgin 20-day female    9 head, mated 1-day female    16 head, mated 4-day female    12 head, mated 20-day female    10 head, mated 1-day male    19 head, mated 4-day male    21 head, mated 20-day male    20 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    15 digestive system, larvae L3 wandering    23 digestive system, 1-day adult    11 digestive system, 4-day adult    15 digestive system, 20-day adult    14 fat body, larvae L3 wandering    6 fat body, white prepupae    13 fat body, pupae P8    10 carcass, larvae L3 wandering    30 carcass, 1-day adult    10 carcass, 4-day adult    13 carcass, 20-day adult    13 ovary, virgin 4-day female    89 ovary, mated 4-day female    85 testis, mated 4-day male    49 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    66 embryo 02-04hr    63 embryo 04-06hr    36 embryo 06-08hr    39 embryo 08-10hr    35 embryo 10-12hr    23 embryo 12-14hr    21 embryo 14-16hr    26 embryo 16-18hr    21 embryo 18-20hr    14 embryo 20-22hr    20 embryo 22-24hr    16 larva L1    9 larva L2    7 larva L3 12hr old    7 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    20 white prepupae new    21 white prepupae 12hr    20 white prepupae 24hr    26 pupae 2d postWPP    16 pupae 3d postWPP    14 pupae 4d postWPP    14 adult male 01day    14 adult male 05day    17 adult male 30day    18 adult female 01day    22 adult female 05day    33 adult female 30day    33 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (66) embryo 02-04hr  (63) embryo 04-06hr  (36) embryo 06-08hr  (39) embryo 08-10hr  (35) embryo 10-12hr    23 embryo 12-14hr    21 embryo 14-16hr  26 embryo 16-18hr    21 embryo 18-20hr    14 embryo 20-22hr    20 embryo 22-24hr    16 larva L1    9 larva L2    7 larva L3 12hr old    7 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    20 white prepupae new    21 white prepupae 12hr    20 white prepupae 24hr  26 pupae 2d postWPP    16 pupae 3d postWPP    14 pupae 4d postWPP    14 adult male 01day    14 adult male 05day    17 adult male 30day    18 adult female 01day    22 adult female 05day  (33) adult female 30day  (33) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    66 embryo 02-04hr    63 embryo 04-06hr    36 embryo 06-08hr    39 embryo 08-10hr    35 embryo 10-12hr    23 embryo 12-14hr    21 embryo 14-16hr    26 embryo 16-18hr    21 embryo 18-20hr    14 embryo 20-22hr    20 embryo 22-24hr    16 larva L1    9 larva L2    7 larva L3 12hr old    7 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    20 white prepupae new    21 white prepupae 12hr    20 white prepupae 24hr    26 pupae 2d postWPP    16 pupae 3d postWPP    14 pupae 4d postWPP    14 adult male 01day    14 adult male 05day    17 adult male 30day    18 adult female 01day    22 adult female 05day    33 adult female 30day    33 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    66 embryo 02-04hr    63 embryo 04-06hr    36 embryo 06-08hr    39 embryo 08-10hr    35 embryo 10-12hr    23 embryo 12-14hr    21 embryo 14-16hr    26 embryo 16-18hr    21 embryo 18-20hr    14 embryo 20-22hr    20 embryo 22-24hr    16 larva L1    9 larva L2    7 larva L3 12hr old    7 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    20 white prepupae new    21 white prepupae 12hr    20 white prepupae 24hr    26 pupae 2d postWPP    16 pupae 3d postWPP    14 pupae 4d postWPP    14 adult male 01day    14 adult male 05day    17 adult male 30day    18 adult female 01day    22 adult female 05day    33 adult female 30day    33 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    66 embryo 02-04hr    63 embryo 04-06hr    36 embryo 06-08hr    39 embryo 08-10hr    35 embryo 10-12hr    23 embryo 12-14hr    21 embryo 14-16hr    26 embryo 16-18hr    21 embryo 18-20hr    14 embryo 20-22hr    20 embryo 22-24hr    16 larva L1    9 larva L2    7 larva L3 12hr old    7 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    20 white prepupae new    21 white prepupae 12hr    20 white prepupae 24hr    26 pupae 2d postWPP    16 pupae 3d postWPP    14 pupae 4d postWPP    14 adult male 01day    14 adult male 05day    17 adult male 30day    18 adult female 01day    22 adult female 05day    33 adult female 30day    33 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (66) embryo 02-04hr  (63) embryo 04-06hr  (36) embryo 06-08hr  (39) embryo 08-10hr  (35) embryo 10-12hr    23 embryo 12-14hr    21 embryo 14-16hr  26 embryo 16-18hr    21 embryo 18-20hr    14 embryo 20-22hr    20 embryo 22-24hr    16 larva L1    9 larva L2    7 larva L3 12hr old    7 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    20 white prepupae new    21 white prepupae 12hr    20 white prepupae 24hr  26 pupae 2d postWPP    16 pupae 3d postWPP    14 pupae 4d postWPP    14 adult male 01day    14 adult male 05day    17 adult male 30day    18 adult female 01day    22 adult female 05day  (33) adult female 30day  (33) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    66 embryo 02-04hr    63 embryo 04-06hr    36 embryo 06-08hr    39 embryo 08-10hr    35 embryo 10-12hr    23 embryo 12-14hr    21 embryo 14-16hr    26 embryo 16-18hr    21 embryo 18-20hr    14 embryo 20-22hr    20 embryo 22-24hr    16 larva L1    9 larva L2    7 larva L3 12hr old    7 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    20 white prepupae new    21 white prepupae 12hr    20 white prepupae 24hr    26 pupae 2d postWPP    16 pupae 3d postWPP    14 pupae 4d postWPP    14 adult male 01day    14 adult male 05day    17 adult male 30day    18 adult female 01day    22 adult female 05day    33 adult female 30day    33 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    66 embryo 02-04hr    63 embryo 04-06hr    36 embryo 06-08hr    39 embryo 08-10hr    35 embryo 10-12hr    23 embryo 12-14hr    21 embryo 14-16hr    26 embryo 16-18hr    21 embryo 18-20hr    14 embryo 20-22hr    20 embryo 22-24hr    16 larva L1    9 larva L2    7 larva L3 12hr old    7 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    20 white prepupae new    21 white prepupae 12hr    20 white prepupae 24hr    26 pupae 2d postWPP    16 pupae 3d postWPP    14 pupae 4d postWPP    14 adult male 01day    14 adult male 05day    17 adult male 30day    18 adult female 01day    22 adult female 05day    33 adult female 30day    33 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    48 Schneider line 2 Sg4    15 embryonic 1182-4H    27 embryonic GM2    41 embryonic Kc167    41 embryonic S1    38 embryonic S3    22 leg disc CME L1    22 wing disc CME-W2    18 wing disc ML-DmD8    27 wing disc ML-DmD9    41 wing disc ML-DmD16-c3    71 wing disc ML-DmD21    12 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    50 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    24 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1    33 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    32 ovary fGS/OSS    58 ovary OSC    50 ovary OSS    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (48) Schneider line 2 Sg4    15 embryonic 1182-4H  (27) embryonic GM2  (41) embryonic Kc167  (41) embryonic S1  (38) embryonic S3    22 leg disc CME L1    22 wing disc CME-W2    18 wing disc ML-DmD8  (27) wing disc ML-DmD9  (41) wing disc ML-DmD16-c3  (71) wing disc ML-DmD21    12 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3  (50) eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    24 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1  (33) CNS ML-DmBG2-c2    10 tumorous blood cells mbn2  (32) ovary fGS/OSS  (58) ovary OSC  (50) ovary OSS  (29) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    48 Schneider line 2 Sg4    15 embryonic 1182-4H    27 embryonic GM2    41 embryonic Kc167    41 embryonic S1    38 embryonic S3    22 leg disc CME L1    22 wing disc CME-W2    18 wing disc ML-DmD8    27 wing disc ML-DmD9    41 wing disc ML-DmD16-c3    71 wing disc ML-DmD21    12 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    50 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    24 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1    33 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    32 ovary fGS/OSS    58 ovary OSC    50 ovary OSS    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    48 Schneider line 2 Sg4    15 embryonic 1182-4H    27 embryonic GM2    41 embryonic Kc167    41 embryonic S1    38 embryonic S3    22 leg disc CME L1    22 wing disc CME-W2    18 wing disc ML-DmD8    27 wing disc ML-DmD9    41 wing disc ML-DmD16-c3    71 wing disc ML-DmD21    12 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    50 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    24 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1    33 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    32 ovary fGS/OSS    58 ovary OSC    50 ovary OSS    29 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    48 Schneider line 2 Sg4    15 embryonic 1182-4H    27 embryonic GM2    41 embryonic Kc167    41 embryonic S1    38 embryonic S3    22 leg disc CME L1    22 wing disc CME-W2    18 wing disc ML-DmD8    27 wing disc ML-DmD9    41 wing disc ML-DmD16-c3    71 wing disc ML-DmD21    12 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    50 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    24 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1    33 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    32 ovary fGS/OSS    58 ovary OSC    50 ovary OSS    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (48) Schneider line 2 Sg4    15 embryonic 1182-4H  27 embryonic GM2  (41) embryonic Kc167  (41) embryonic S1  (38) embryonic S3    22 leg disc CME L1    22 wing disc CME-W2    18 wing disc ML-DmD8  27 wing disc ML-DmD9  (41) wing disc ML-DmD16-c3  (71) wing disc ML-DmD21    12 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3  (50) eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    24 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1  (33) CNS ML-DmBG2-c2    10 tumorous blood cells mbn2  32 ovary fGS/OSS  (58) ovary OSC  (50) ovary OSS  29 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    48 Schneider line 2 Sg4    15 embryonic 1182-4H    27 embryonic GM2    41 embryonic Kc167    41 embryonic S1    38 embryonic S3    22 leg disc CME L1    22 wing disc CME-W2    18 wing disc ML-DmD8    27 wing disc ML-DmD9    41 wing disc ML-DmD16-c3    71 wing disc ML-DmD21    12 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    50 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    24 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1    33 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    32 ovary fGS/OSS    58 ovary OSC    50 ovary OSS    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    48 Schneider line 2 Sg4    15 embryonic 1182-4H    27 embryonic GM2    41 embryonic Kc167    41 embryonic S1    38 embryonic S3    22 leg disc CME L1    22 wing disc CME-W2    18 wing disc ML-DmD8    27 wing disc ML-DmD9    41 wing disc ML-DmD16-c3    71 wing disc ML-DmD21    12 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    50 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    24 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1    33 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    32 ovary fGS/OSS    58 ovary OSC    50 ovary OSS    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    32 cold shock, 4-day adult    22 heat shock, 4-day adult    30 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    33 Cadmium 100 mM 48 hrs, 4-day adult    66 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult    67 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    30 Ethanol 2.5% 3 hrs, larvae L3    57 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    59 Caffeine 25 mg/ml 48 hrs, 4-day adult    32 Paraquat 5 mM 48 hrs, 4-day adult    45 Paraquat 10 mM 48 hrs, 4-day adult    39 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (32) cold shock, 4-day adult    22 heat shock, 4-day adult  (30) Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult  (33) Cadmium 100 mM 48 hrs, 4-day adult  (66) Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult  (67) Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult  (30) Ethanol 2.5% 3 hrs, larvae L3  (57) Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (59) Caffeine 25 mg/ml 48 hrs, 4-day adult  (32) Paraquat 5 mM 48 hrs, 4-day adult  (45) Paraquat 10 mM 48 hrs, 4-day adult  (39) Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    32 cold shock, 4-day adult    22 heat shock, 4-day adult    30 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    33 Cadmium 100 mM 48 hrs, 4-day adult    66 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult    67 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    30 Ethanol 2.5% 3 hrs, larvae L3    57 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    59 Caffeine 25 mg/ml 48 hrs, 4-day adult    32 Paraquat 5 mM 48 hrs, 4-day adult    45 Paraquat 10 mM 48 hrs, 4-day adult    39 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    32 cold shock, 4-day adult    22 heat shock, 4-day adult    30 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    33 Cadmium 100 mM 48 hrs, 4-day adult    66 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult    67 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    30 Ethanol 2.5% 3 hrs, larvae L3    57 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    59 Caffeine 25 mg/ml 48 hrs, 4-day adult    32 Paraquat 5 mM 48 hrs, 4-day adult    45 Paraquat 10 mM 48 hrs, 4-day adult    39 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    32 cold shock, 4-day adult    22 heat shock, 4-day adult    30 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    33 Cadmium 100 mM 48 hrs, 4-day adult    66 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult    67 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    30 Ethanol 2.5% 3 hrs, larvae L3    57 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    59 Caffeine 25 mg/ml 48 hrs, 4-day adult    32 Paraquat 5 mM 48 hrs, 4-day adult    45 Paraquat 10 mM 48 hrs, 4-day adult    39 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  32 cold shock, 4-day adult    22 heat shock, 4-day adult  30 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult  (33) Cadmium 100 mM 48 hrs, 4-day adult  (66) Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult  (67) Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult  30 Ethanol 2.5% 3 hrs, larvae L3  (57) Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (59) Caffeine 25 mg/ml 48 hrs, 4-day adult  32 Paraquat 5 mM 48 hrs, 4-day adult  (45) Paraquat 10 mM 48 hrs, 4-day adult  (39) Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    32 cold shock, 4-day adult    22 heat shock, 4-day adult    30 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    33 Cadmium 100 mM 48 hrs, 4-day adult    66 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult    67 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    30 Ethanol 2.5% 3 hrs, larvae L3    57 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    59 Caffeine 25 mg/ml 48 hrs, 4-day adult    32 Paraquat 5 mM 48 hrs, 4-day adult    45 Paraquat 10 mM 48 hrs, 4-day adult    39 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    32 cold shock, 4-day adult    22 heat shock, 4-day adult    30 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    33 Cadmium 100 mM 48 hrs, 4-day adult    66 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult    67 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    30 Ethanol 2.5% 3 hrs, larvae L3    57 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    59 Caffeine 25 mg/ml 48 hrs, 4-day adult    32 Paraquat 5 mM 48 hrs, 4-day adult    45 Paraquat 10 mM 48 hrs, 4-day adult    39 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_01 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	BDGP expression data • LP01280 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003138 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9181-RC;CG9181-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Ptp61F Stages(s) 1-3 Stages(s) 4-6 Stages(s) 9-10 Stages(s) 11-12
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable Ptp61Ff06926 Ptp61FLA00327 viable, with Scer\GAL4pnr-MD237 Ptp61FGD3571 Sterility Allele fertile Ptp61Ff06926 Ptp61FLA00327 Phenotype manifest in Allele
Classical Alleles ( 31 )
For All Classical Alleles Show
Allele of Ptp61F Class Mutagen Stocks Known lesion Ptp61Fc05292 piggyBac transposase 2 -- Ptp61Ff06926 piggyBac transposase 2 -- Ptp61FLA00327 P-element activity 2 -- Ptp61FB106 1 -- Ptp61FBG02243 1 -- Ptp61Fc00282 piggyBac transposase 1 -- Ptp61Fc05697 piggyBac transposase 1 -- Ptp61Fc05849 piggyBac transposase 1 -- Ptp61Fd01050 1 -- Ptp61Fd07829 P-element activity 1 -- Ptp61Fe00366 piggyBac transposase 1 -- Ptp61Ff00532 piggyBac transposase 1 -- Ptp61Ff07223 1 -- Ptp61FG8581 P-element activity 1 -- Ptp61FMB00652 1 -- Ptp61FMB00813 1 -- Ptp61FMB08823 1 -- Ptp61FMI00172 1 -- Ptp61FMI01473 1 -- Ptp61FMI03132 1 -- Ptp61FMI05014 1 -- Ptp61FMI05994 1 -- Ptp61FMI06001 1 -- Ptp61FMI07350 1 -- Ptp61F5-HA-2445 0 -- Ptp61Fd07829-f07223 FLPase 0 Yes Ptp61Fd07943 P-element activity 0 -- Ptp61Fe01281 piggyBac transposase 0 -- Ptp61FEP826 P-element activity 0 Yes Ptp61Ff05423-d01050 FLPase 0 Yes Ptp61FMB04181 0 --
Alleles Carried on Transgenic Constructs ( 12 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Ptp61F Class Mutagen Stocks Known lesion Ptp61FGD3571 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Ptp61FHMS00421 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Ptp61Fa.Act5C in vitro construct - regulatory fusion 0 Yes Ptp61Fa.Scer\UAS in vitro construct - regulatory fusion 0 Yes Ptp61Fc.Act5C in vitro construct - regulatory fusion 0 Yes Ptp61Fc.Scer\UAS in vitro construct - regulatory fusion 0 Yes Ptp61FdsRNA.cCa in vitro construct - RNAi 0 Yes Ptp61FdsRNA.Scer\UAS.WIZ in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes Ptp61FKK101883 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Ptp61Fm.Scer\UAS in vitro construct - regulatory fusion 0 Yes Ptp61FNIG.9181R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Ptp61FScer\UAS.cBa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)ED4238 (Baeg et al., 2005)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD3571} NA P{KK101883} NA P{NIG.9181R} NA P{TRiP.HMS00421} NA P{UAS-Ptp61F.a} NA P{UAS-Ptp61F.B} NA P{UAS-Ptp61F.c} NA P{UAS-Ptp61F.m} NA P{UAS-Ptp61F.RNAi} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}312EP826 NA P{EP}Ptp61FG8581 NA P{GSV1}C865C865 NA P{Mae-UAS.6.11}Ptp61FLA00327 NA P{XP}Ptp61Fd01050 NA P{XP}Ptp61Fd07829 NA P{XP}Ptp61Fd07943 NA miscellaneous insertions Mi{MIC}Ptp61FMI00172 NA Mi{MIC}Ptp61FMI01473 NA Mi{MIC}Ptp61FMI03132 NA Mi{MIC}Ptp61FMI05014 NA Mi{MIC}Ptp61FMI05994 NA Mi{MIC}Ptp61FMI06001 NA Mi{MIC}Ptp61FMI07350 NA P{GT1}Ptp61FBG02243 NA P{RS5}Ptp61F5-HA-2445 NA PBac{5HPw+}Ptp61FB106 NA PBac{PB}312c05697 NA PBac{PB}Ptp61Fc00282 NA PBac{PB}Ptp61Fc05292 NA PBac{PB}Ptp61Fc05697 NA PBac{PB}Ptp61Fc05849 NA PBac{RB}Ptp61Fe00366 NA PBac{RB}Ptp61Fe01281 NA PBac{WH}Ptp61Ff00532 NA PBac{WH}Ptp61Ff06926 NA PBac{WH}Ptp61Ff07223 NA insertion of enhancer trap binary system Mi{ET1}CG32320MB04181 No Mi{ET1}Ptp61FMB00652 No Mi{ET1}Ptp61FMB00813 No Mi{ET1}Ptp61FMB08823 No
Gene Ontology: Function, Process & Cellular Component ( 15 unique terms )
Terms Based on Experimental Evidence ( 15 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with Abi (Huang et al., 2007) protein tyrosine phosphatase activity inferred from direct assay (McLaughlin and Dixon, 1993) inferred from direct assay AND inferred from sequence or structural similarity (McLaughlin and Dixon, 1993) inferred from mutant phenotype (Huang et al., 2007)
Biological Process
CV term Evidence References
axon guidance inferred from physical interaction with dock (Clemens et al., 1996) cellular response to hypoxia inferred from mutant phenotype (Lee et al., 2008) germ-band extension inferred from direct assay (assigned by UniProtKB) (Ursuliak et al., 1997) mitotic cell cycle inferred from mutant phenotype (Chen et al., 2007) negative regulation of JAK-STAT cascade inferred from mutant phenotype (Muller et al., 2005) negative regulation of peptidyl-tyrosine phosphorylation inferred from mutant phenotype (Huang et al., 2007) oogenesis inferred from direct assay (assigned by UniProtKB) (Ursuliak et al., 1997) protein dephosphorylation inferred from direct assay (McLaughlin and Dixon, 1993) regulation of protein localization inferred from direct assay (Huang et al., 2007) regulation of protein stability inferred from mutant phenotype (Huang et al., 2007)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (McLaughlin and Dixon, 1993) nucleus inferred from direct assay (McLaughlin and Dixon, 1993) perinuclear region of cytoplasm inferred from direct assay (Huang et al., 2007)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
protein tyrosine phosphatase activity non-traceable author statement (McLaughlin, 1993.5.19, Zou et al., 2000, Morrison et al., 2000)
Biological Process
CV term Evidence References
protein dephosphorylation non-traceable author statement (Morrison et al., 2000)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Ptp61F - Btk29A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ptp61F - CG10641 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ptp61F - FK506-bp2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ptp61F - Rsf1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ptp61F - SH3PX1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ptp61F - Tm1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ptp61F - dock anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Ptp61F allele Gene References Ptp61Fc.Scer\UAS hop (Muller et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 63702 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0003138 DroID - A comprehensive database of gene and protein interactions. • FBgn0003138 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38160 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q8IRH4
Orthologs
OrthoDB Orthologs (44) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG66T3M5 Dipteran inclusive ortholog search EOG6907J8 Insect inclusive ortholog search EOG6KWHP7 Arthropod inclusive ortholog search EOG6KWH87 Metazoa inclusive ortholog search EOG6103R3
Orthologs in Drosophila Species (EOG66T3M5)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Ptp61F     Drosophila simulans   Dsim\GD13480 Y   Drosophila sechellia   Dsec\GM14217 Y   Drosophila erecta   Dere\GG14603 Y   Drosophila yakuba   Dyak\GE20964 Y   Drosophila ananassae   Dana\GF10060 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA21595 Y   Drosophila persimilis   Dper\GL20849 Y   Drosophila willistoni   Dwil\GK16610 Y   Drosophila virilis   Dvir\GJ12338 Y   Drosophila mojavensis   Dmoj\GI12440 Y   Drosophila grimshawi   Dgri\GH16593 Y
Orthologs in non-Drosophila Dipterans (EOG6907J8)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL001919   Anopheles gambiae Malaria mosquito  Agam\AGAP005352   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ011976
Orthologs in non-Dipteran Insects (EOG6KWHP7)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB48145   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG007134   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH10785   Atta cephalotes Leafcutter ant  Acep\ACEP13535   Camponotus floridanus Florida carpenter ant  Cflo\CFLO17010   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL21037   Linepithema humile Argentine ant  Lhum\LH10126   Pogonomyrmex barbatus Red harvester ant  Pbar\PB10373   Solenopsis invicta Red fire ant  Sinv\SINV13274   Acyrthosiphon pisum Pea aphid  Apim\ACYPI008536   Bombyx mori Silkmoth  Bmor\BGIBMGA002096   Pediculus humanus Human body louse  Phum\PHUM581330   Tribolium castaneum Red flour beetle  Tcas\TC003328
Orthologs in non-Insect Arthropods (EOG6KWH87)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\psbA
Orthologs in non-Arthropod Metazoa (EOG6103R3)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_020281gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_017995gn   Danio rerio Zebrafish  Drer\ptpn2l   Danio rerio Zebrafish  Drer\ptpn1   Danio rerio Zebrafish  Drer\ptpn2a   Xenopus tropicalis Western clawed frog  Xtro\ptpn1   Xenopus tropicalis Western clawed frog  Xtro\ptpn2   Gallus gallus Domestic chicken  Ggal\PTPN1   Gallus gallus Domestic chicken  Ggal\PTPN2   Mus musculus House mouse  Mmus\Ptpn2   Mus musculus House mouse  Mmus\Ptpn1   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000017453   Rattus norvegicus Norway rat  Rnor\Ptpn1   Homo sapiens Human  Hsap\PTPN1   Homo sapiens Human  Hsap\PTN2
Human Orthologs (2)
Gene OMIM HGNC Hsap\PTPN1     Hsap\PTN2
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD13480 Drosophila sechellia Dsec\GM14217 Drosophila erecta Dere\GG14603 Drosophila yakuba Dyak\GE20964 Drosophila ananassae Dana\GF10060 Drosophila pseudoobscura pseudoobscura Dpse\GA21595 Drosophila persimilis Dper\GL20849 Drosophila willistoni Dwil\GK16610 Drosophila virilis Dvir\GJ12338 Drosophila mojavensis Dmoj\GI12440 Drosophila grimshawi Dgri\GH16593
Stocks & Reagents
Stocks Listed in FlyBase ( 30 )
Harvard	- P{XP}Ptp61Fd01050 - P{XP}Ptp61Fd07829 - PBac{PB}Ptp61Fc00282 - PBac{PB}Ptp61Fc05292 - PBac{PB}Ptp61Fc05697 - PBac{PB}Ptp61Fc05849 - PBac{RB}Ptp61Fe00366 - PBac{WH}Ptp61Ff00532 - PBac{WH}Ptp61Ff06926 - PBac{WH}Ptp61Ff07223
VDRC	v37436 w1118; P{GD3571}v37436 v37437 w1118; P{GD3571}v37437/TM3
	More stocks available...
Genomic Clones ( 2 )
	BACR17K17 BACR27O01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 243 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GM09783 LP01280 LP02164 RE73935
Other clones	DPiM_LP01280 FI19882
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT10282 AT14029 AT14033 AT18821 AT19269 AT20426 AT20873 AT28161 AT31981 GH07203 GH26214 HL01022 HL01331 HL01534 LD08378 LD10932 LD13842 LD16615 LD22541 LD22735 LD22743 LD24480 LD26937 LD30440 LD31179 LD32012 LD37180 LD37465 LD37740 LD38107 LD39771 LD43436 LD43526 LD44050 LD44468 LD44974 LD46183 LD46316 LD46748 LD46759 LD46771 LD46772 LD47194 LD47476 LD47685 LD47707 LP04519 RE03330 RE03988 RE04875 RE07716 RE08593 RE12493 RE14680 RE14948 RE15435 RE15780 RE16167 RE19694 RE21856 RE22274 RE22367 RE25610 RE26057 RE30462 RE30961 RE32854 RE33760 RE34388 RE34895 RE36191 RE36292 RE36528 RE37302 RE38450 RE38550 RE40558 RE40607 RE42176 RE44844 RE46178 RE46319 RE46406 RE46907 RE48366 RE49495 RE49652 RE51395 RE57553 RE57761 RE60358 RE61104 RE62285 RE63701 RE64344 RE64486 RE65760 RE65959 RE66455 RE68511 RE68867 RE69721 RE70867 RE71566 RE72314 RE73258 RE73353 RE73436 RE73492 RE74302 RE74405 RE74695 RE74908 RH02041 RH04810 RH04851 RH05833 RH08030 RH15080 RH18014 RH35086 RH42109 RH43122 RH52737 RH57536 RH61331 RH62408 RH63639 RH64663 RH66446 RH74613 SD02289 SD03350 SD03405 SD05138 SD12520 SD13664 SD13735 SD25386
Other clones	10975 33982 43839 58041 59973 69655 70993 101272 102542 107796 160506 163202 175210 177599 177770 181429 193197 214407.24 522129 CK01.50D.A2 CK01.59A.D11 Dmel_neb_001006_0110_3648 Dmel_neb_015829_0339_2113 EC052157 EC052646 EC052647 EC053146 EC053147 EC054824 EC055680 EC056092 EC056402 EK041733 EK047912 EK060807 EK146515 EK159215 EK177507 EK199017 EK225635 EK234243 EK243561 EK263543 EK267223 EK279210 EK282632 EK287135 EK296426 EN01426 EP03203 EP04458 EP08464 ESG015d.E21.1_E11 FGM101B06 GM12509 IP03335 LD15970 LD30437 LD35034 RE01370 RE01571 RE04848 RE19940 RE25616 RE40162 RE57187 RE66502 RE69865 RP001020125 RP004005743 RP004006540 RP004041211 RP004065308 RP004074107 RP004120129 RP004140453 RP004190710 RP004215384 RP004215648 RP004217266 RP004218860 RP004222947 RP004227269 RP004252192 RP004256331 RP004258280 RP004290124 RP004306373 RP004324709 RP004336515 RP004383956 RP004412955 RP004440131 RP004500089 RP004508263 RP004535179 RP004558000 SD05388
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0003138 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38160
Antibody Information
	polyclonal (Clemens et al., 1996, McLaughlin and Dixon, 1993, McLaughlin and Dixon, 1993)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Ptp61F anon-WO0140519.98 anon-WO0118547.297 (FlyBase, 1996-) Source for merge of: Ptp61F BEST:LP01280 (FlyBase, 1996-) Source for merge of: Ptp61F CG9178 (FlyBase, 1996-)
Additional comments	Source for merge of Ptp61F BEST:LP01280 was a shared cDNA (date:030206). (FlyBase, 1996-) Source for merge of Ptp61F anon-WO0140519.98 anon-WO0118547.297 was sequence comparison (date:051113). (FlyBase, 1996-) Release 1 annotation CG9178 corresponds to part of release 3.2 annotation CG9181 (which is Ptp61F). (FlyBase, 1996-)
Other Comments
	Ptp61F negatively regulates JAK/STAT signaling and is also a transcriptional target of JAK/STAT signaling. (Baeg et al., 2005) S2-derived S2-NP cells treated with dsRNA made from templates generated with primers directed against Ptp61F experience a more than four-fold increase in Stat92E-dependent reporter activity and a significant increase in Stat92E phosphorylation. dsRNA knock-down also results in a dramatic increase in tyrosine phosphorylation of hop protein. (Baeg et al., 2005) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Area matching Drosophila EST AA567483 (inverted). (Davies, 2001.3.15) The spatial and temporal expression of two alternative transcripts of Ptp61F during Drosophila embryogenesis has been analysed in wild-type embryos and in embryos mutant for pair-rule and segment-polarity genes. (Ursuliak et al., 1997) Spatial and temporal transcript accumulation pattern in ovaries is determined by in situ hybridisation. (Fitzpatrick et al., 1995) Two 3' splice variants of this gene generate two proteins that differ in their C-termini. One is targeted to the cytoplasmic membrane, the other to the nucleus. (McLaughlin and Dixon, 1993)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057339 NM_057340 NM_167874 NM_167875 NM_001274324 RefSeq (Proteins) • NP_476687 NP_476688 NP_728600 NP_728601 NP_001261253 DDBJ / EMBL / GenBank • AA567483 AAA28748 AAA75338 AAA75339 AAA75348 AAA75349 AAF47486 AAF47487 AAL39858 AAN11475 AAN11476 AC004489 AC005847 AGB93948 AI258156 AW943967 AX094173 AX154749 AY069713 CZ466343 CZ469851 CZ470193 CZ470300 CZ475944 CZ476005 CZ478262 CZ479087 CZ482995 CZ489663 CZ489664 DU708629 L11249 L11250 L11251 L11252 L11253 L14849 Entrez Gene - A searchable database of RefSeq genes. • 38160 UniProtKB/Swiss-Prot • Q9W0G1 UniProtKB/TrEMBL • Q8IRH4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein-tyrosine phosphatase, receptor/non-receptor type (IPR000242) Protein-tyrosine/Dual specificity phosphatase (IPR000387) Protein-tyrosine phosphatase, active site (IPR016130) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LP01280
Linkouts
	BioGRID - A database of protein and genetic interactions • 63702 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0003138 DroID - A comprehensive database of gene and protein interactions. • FBgn0003138 DRSC - Results from RNAi screens. • FBgn0003138 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003138 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9181-RC;CG9181-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0003138 FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways • 415769 152593 152594 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38160 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38160 modMine - Data generated by the modENCODE project. • FBgn0003138 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q8IRH4
Synonyms & Secondary IDs ( 17 )
Reported As
Symbol Synonym	anon-WO0118547.297   anon-WO0140519.98   BEST:LP01280   CG9178   CG9181 (Morrison et al., 2000, Molnar et al., 2006, Lee et al., 2008, Keleman et al., 2009.8.5, Ni et al., 2010.12.1) DPTP61F (Muda et al., 2002, Clemens et al., 2000, den Hertog, 1999, Stoker and Dutta, 1998, Ursuliak et al., 1997, Nieto, 1996, Ursuliak et al., 1996, Fitzpatrick et al., 1995) dPTP61F (Walchli et al., 2000, Garcia-Alonso, 1999, McCarty, 1998, Clemens et al., 1996, McLaughlin and Dixon, 1993, Erfurth and Schmucker, 2008) dptp61F (Ursuliak et al., 1997) PTB61F (Wu et al., 2011) PTP61F (Baeg et al., 2005, Kung, 1993, Gotea and Makalowski, 2006, Huang et al., 2007, Arbouzova and Zeidler, 2006, Perrimon and Mathey-Prevot, 2007, Huang et al., 2007, Ku et al., 2009) ptp61F (Muller, 2005, Arbouzova and Zeidler, 2006, Guan et al., 2011, Wright et al., 2011) Ptp61F (Chen et al., 2007, Baeg et al., 2007, Molnar et al., 2006, Bakal et al., 2008, Lee et al., 2008, Lipatov et al., 2005, Hilger et al., 2009, Wei et al., 2003, Yu et al., 2010, Muller et al., 2005, Japanese National Institute of Genetics, 2012.5.21, Gurudatta et al., 2012) R-PTP 61F (Morrison et al., 2000)
Name Synonym	protein tyrosine phosphatase (McLaughlin, 1993.5.19, McLaughlin, 1993.5.19, McLaughlin, 1993.5.19, McLaughlin, 1995.9.13, McLaughlin, 1993.5.19) protein-tyrosine-phosphatase (Zou et al., 2000) Protein tyrosine phosphatase 61F (Guan et al., 2011) protein tyrosine phosphatase 61F (Lee et al., 2008)
Secondary FlyBase IDs
	FBgn0035219 FBgn0043788 FBgn0044527 FBgn0062112
References ( 96 )
Generate a list of	All references relating to this gene ( 96 )
List References by type	Research paper  ( 32 ) Supplementary material  ( 9 ) Review  ( 7 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 25 ) Abstract  ( 5 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 7 ) Conference report  ( 1 ) Stock list  ( 1 ) Patent  ( 2 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 10 )
	Buszard et al., 2013, Mol. Cell. Biol. 33(7): 1345--1356 The Nucleus- and Endoplasmic Reticulum-Targeted Forms of Protein Tyrosine Phosphatase 61F Regulate Drosophila Growth, Life Span, and Fecundity. [FBrf0220991] Fabian et al., 2012, Mol. Ecol. 21(19): 4748--4769 Genome-wide patterns of latitudinal differentiation among populations of Drosophila melanogaster from North America. [FBrf0219505] Fisher et al., 2012, BMC Genomics 13: 506 Advances in genome-wide RNAi cellular screens: a case study using the Drosophila JAK/STAT pathway. [FBrf0220361] Gurudatta et al., 2012, Dev. Biol. 369(1): 124--132 The BEAF insulator regulates genes involved in cell polarity and neoplastic growth. [FBrf0219796] Issigonis and Matunis, 2012, Dev. Biol. 368(2): 181--192 The Drosophila BCL6 homolog ken and barbie promotes somatic stem cell self-renewal in the testis niche. [FBrf0218994] Krauchunas et al., 2012, Dev. Biol. 370(1): 125--134 Protein phosphorylation changes reveal new candidates in the regulation of egg activation and early embryogenesis in D. melanogaster. [FBrf0219342] Guan et al., 2011, Learn. Mem. 18(4): 191--206 Altered gene regulation and synaptic morphology in Drosophila learning and memory mutants. [FBrf0213277] Horn et al., 2011, Nat. Methods 8(4): 341--346 Mapping of signaling networks through synthetic genetic interaction analysis by RNAi. [FBrf0213352] Wright et al., 2011, Cell. Signal. 23(5): 920--927 Differential activities of the Drosophila JAK/STAT pathway ligands Upd, Upd2 and Upd3. [FBrf0213113] Wu et al., 2011, Biochem. J. 439(1): 151--159 Dock/Nck facilitates PTP61F/PTP1B regulation of insulin signalling. [FBrf0215594] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...