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Gene Dmel\Ptp61F

General Information
Symbol	Dmel\Ptp61F	Species	D. melanogaster
Name	Protein tyrosine phosphatase 61F	Annotation symbol	CG9181
Feature type	protein_coding_gene	FlyBase ID	FBgn0003138
Gene Model Status	Current	Stock availability	25 publicly available
Also Known As	DPTP61F
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	61F7-62A2	Sequence location	3L:1,342,493..1,475,249 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Protein tyrosine phosphatase 61F is referred to in FlyBase by the symbol Dmel\Ptp61F (CG9181, FBgn0003138). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein tyrosine phosphatase activity; protein binding. There is experimental evidence that it is involved in the biological process: mitotic cell cycle; negative regulation of peptidyl-tyrosine phosphorylation; regulation of protein stability; protein dephosphorylation; axon guidance; germ-band extension; cellular response to hypoxia; oogenesis; regulation of protein localization. 36 alleles are reported. No phenotypic data is available. It has 5 annotated transcripts and 5 annotated polypeptides. Protein features are: Protein-tyrosine phosphatase, active site; Protein-tyrosine phosphatase, non-receptor type-1, -2; Protein-tyrosine phosphatase, receptor/non-receptor type; Protein-tyrosine/Dual-specificity phosphatase. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult female reproductive system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval Malpighian tubules, adult heart, larval/adult salivary gland, larval trachea, inseminated spermatheca, adult male reproductive system, larval carcass. Gene sequence location is 3L:1342493..1475249.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Bellen, 2011.10.10, MISet953.xml Insertions Mi{MIC}Ptp61F[MI03132] Polypeptides Ptp61F-PE Transcripts Ptp61F-RE Alleles Ptp61F[MI03132] Clones Dmel_neb_001006_0110_3648 RE14680 RE21856 RE22274 RE73436 59973 ESG015d.E21.1_E11 177770 EP04458 107796 EP03203 EK234243 EK282632
FB2012_01	Alleles Ptp61F[MI01473] Insertions Mi{MIC}Ptp61F[MI01473] Sequence features BKN60273 BKN60242 BKN21934 HFA08683 References Bellen, 2011.11.10, set958.xml
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 61F7-62A2   Limits computationally determined from genome sequence between P{PZ}l(3)0264002640 and P{EP}rhoEP3704&P{PZ}l(3)0622606226
Experimentally Determined Cytological Location
Cytogenetic map Notes References 61F-61F     (McLaughlin, 1993.5.19) 61F-61F   (determined by in situ hybridisation)   (McLaughlin and Dixon, 1993)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Ptp61F for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.42
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Ptp61F-RA FBtr0072718  NM_057339   2181   548 Ptp61F-RB FBtr0072717  NM_057340   1901   535 Ptp61F-RC FBtr0072716  NM_167874   1796   530 Ptp61F-RD FBtr0072719  NM_167875   2606   431 Ptp61F-RE FBtr0310161     5159   431
Additional Transcript Data & Comments
Reported size (kB)	2.8, 2.0 (northern blot) (McLaughlin and Dixon, 1993)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Ptp61F-PA   FBpp0072602   62.1   548   5.24     NP_476687   AAF47487 Ptp61F-PB   FBpp0072601   61.0   535   5.76     NP_476688   AAF47486 Ptp61F-PC   FBpp0072600   60.5   530   5.90     NP_728600   AAN11475 Ptp61F-PD   FBpp0072603   48.5   431   4.81     NP_728601   AAN11476 Ptp61F-PE   FBpp0301846   48.5   431   4.81
Additional Polypeptide Data & Comments
Reported size (kDa)	548, 535 (aa); 62, 61 (kD) (McLaughlin and Dixon, 1993) 72 (kD observed) (Clemens et al., 1996)
Comments	In vitro and in vivo interaction between Ptp61F and dock proteins were demonstrated. One or more of the SH3 domains of dock protein likely mediate the interaction with a region of the Ptp61F protein containing five PXXP-motifs (where X represents any amino acid). (Clemens et al., 1996) The Ptp61F proteins are 33-34% identical overall to other protein tyrosine phosphatases and 50% identical in the catalytic domain. Ptp61F proteins expressed as fusions with glutathione S-tranferase were shown to have tyrosine phosphatase activity. The carboxy terminal sequences were implicated in targeting of the two protein forms to either the cytoplasm or nucleus. (McLaughlin and Dixon, 1993) The Ptp61F proteins are 33-34% identical overall to other protein tyrosine phosphatases and 50% identical in the catalytic domain. Ptp61F proteins expressed as fusions with glutathione S-tranferase were shown to have tyrosine phosphatase activity. The carboxy terminal sequences were implicated in targeting of the two protein forms to either the cytoplasm or the nucleus. (McLaughlin and Dixon, 1993)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein-tyrosine phosphatase, receptor/non-receptor type (IPR000242) Protein-tyrosine/Dual-specificity phosphatase (IPR000387) Protein-tyrosine phosphatase, non-receptor type-1, -2 (IPR012265) Protein-tyrosine phosphatase, active site (IPR016130)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA264705   AA391989   AA439309   AA441223   AA441619   AA567352   AA567483   AA567617   AA804005   AA817304   AA820650   AA940671   AA940674   AA942616   AA950581   AA950583   AA950979   AA978591   AE014296 AAF47486   AE014296 AAF47487   AE014296 AAN11475   AE014296 AAN11476   AC004489   AC005847   AI061941   AI258156   AI260592   AI406028   AI456987   AI511881   AI511944   AI512270   AI512560   AI512887   AI514643   AI515068   AI515078   AI515088   AI515089   AI515388   AI515589   AI518056   AI518271   AI518550   AI519924   AI531311   AI532011   AI532045   AI533354   AI533532   AI544084   AI544225   AI544237   AW943967   AX094173   AX154749   AY060968   AY069713 AAL39858   BF486201   BF486545   BF491423   BF496522   BF499467   BF499471   BF502951   BF503310   BG632364   BG635400   BG636075   BG636137   BG639746   BG641229   BI161905   BI161906   BI162187   BI162188   BI163818   BI164333   BI165045   BI165068   BI167349   BI168058   BI170889   BI172336   BI172453   BI172763   BI173047   BI214014   BI214203   BI215454   BI215689   BI215764   BI228159   BI228165   BI228498   BI230904   BI234714   BI235150   BI236747   BI237519   BI238028   BI238429   BI239646   BI239723   BI239899   BI240453   BI241394   BI241471   BI242746   BI243029   BI243062   BI356116   BI358158   BI361808   BI361910   BI362366   BI363532   BI364399   BI364515   BI365692   BI365986   BI372026   BI372047   BI372058   BI373138   BI373720   BI374645   BI375819   BI481743   BI481877   BI482950   BI483118   BI483544   BI483585   BI485218   BI485521   BI486304   BI486439   BI564872   BI565814   BI566006   BI569870   BI571025   BI572498   BI577215   BI577815   BI578441   BI579259   BI579335   BI579409   BI579461   BI580157   BI580246   BI580496   BI580686   BI591096   BI591131   BI607529   BI610151   BI611641   BI613041   BI613867   BI621401   BI624920   BI625936   BI628789   BI631700   BI641774   BP549370   BT056312   BT120050   CA807003   CO153177   CO188737   CO190360   CO266469   CO281967   CO285819   CO292015   CO300155   CO304076   CO311640   CO313893   CO316057   CO317152   CO319568   CO320177   CO320686   CO326072   CO326700   CO328047   CO330914   CZ466343   CZ469851   CZ470193   CZ470300   CZ475944   CZ476005   CZ478262   CZ479087   CZ482995   CZ489663   CZ489664   DU708629   EC052157   EC052646   EC052647   EC053146   EC053147   EC054824   EC055680   EC056092   EC056402   EC067530   EC071976   EC073489   EC074348   EC076674   EC089357   EC090008   EC202309   EC206956   EC210307   EC211562   EC216086   EC229687   EC238608   EC239021   EC239161   EC246866   EC246954   EC248102   EC255279   EC265420   EL871199   EV587018   EV590762   GH739273   GH945731   GH946178   GH946813   GH949267   GH952656   GH954124   GH956663   GH957106   GH958179   GH959268   GH959284   GH959477   GH961366   GH964040   GH964697   GH969490   GH971423   GH973313   GH975715   GH976181   GH976949   GH977482   GH978621   GH978731   GH979243   GH982657   GH982863   GH982923   L11249   L11250 AAA75348   L11251 AAA75349   L11252 AAA75338   L11253 AAA75339   L14849 AAA28748
UniProtKB/Swiss-Prot	Q9W0G1
UniProtKB/TrEMBL	Q8IRH4
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage & pupal stage & adult stage     (Clemens et al., 1996) embryonic stage 14   presumptive embryonic/larval central nervous system   (Clemens et al., 1996)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
	The 535aa form of Ptp61F localizes to the nucleus when expressed in COS cells. (McLaughlin and Dixon, 1993) The 548aa form of Ptp61F protein localizes to a "reticular" network as well as to mitochondria-like organelles when expressed in COS cells. (McLaughlin and Dixon, 1993)
Marker for
Subcellular Localization
CV Term	cytoplasm mitochondrion (McLaughlin and Dixon, 1993) nucleus (McLaughlin and Dixon, 1993)
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0003138    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0003138 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0003138 expression level Developmental Stage   Expression Level embryo 00-02hr    9177 embryo 02-04hr    8755 embryo 04-06hr    4895 embryo 06-08hr    5358 embryo 08-10hr    4830 embryo 10-12hr    3223 embryo 12-14hr    2831 embryo 14-16hr    3631 embryo 16-18hr    2895 embryo 18-20hr    1908 embryo 20-22hr    2736 embryo 22-24hr    2105 larva L1    1308 larva L2    992 larva L3 12hr old    919 larva L3 puffstage 1-2    1067 larva L3 puffstage 3-6    1957 larva L3 puffstage 7-9    2552 white prepupae new    2675 white prepupae 12hr    2559 white prepupae 24hr    3343 pupae 2d postWPP    2111 pupae 3d postWPP    1886 pupae 4d postWPP    1940 adult male 01day    1886 adult male 05day    2366 adult male 30day    2540 adult female 01day    3045 adult female 05day    4444 adult female 30day    4504 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (9177) embryo 02-04hr  (8755) embryo 04-06hr  (4895) embryo 06-08hr  (5358) embryo 08-10hr  (4830) embryo 10-12hr  (3223) embryo 12-14hr  (2831) embryo 14-16hr  (3631) embryo 16-18hr  (2895) embryo 18-20hr  (1908) embryo 20-22hr  (2736) embryo 22-24hr  (2105) larva L1  (1308) larva L2  (992) larva L3 12hr old  (919) larva L3 puffstage 1-2  (1067) larva L3 puffstage 3-6  (1957) larva L3 puffstage 7-9  (2552) white prepupae new  (2675) white prepupae 12hr  (2559) white prepupae 24hr  (3343) pupae 2d postWPP  (2111) pupae 3d postWPP  (1886) pupae 4d postWPP  (1940) adult male 01day  (1886) adult male 05day  (2366) adult male 30day  (2540) adult female 01day  (3045) adult female 05day  (4444) adult female 30day  (4504) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (9177) embryo 02-04hr  (8755) embryo 04-06hr  (4895) embryo 06-08hr  (5358) embryo 08-10hr  (4830) embryo 10-12hr  (3223) embryo 12-14hr  (2831) embryo 14-16hr  (3631) embryo 16-18hr  (2895) embryo 18-20hr  (1908) embryo 20-22hr  (2736) embryo 22-24hr  (2105) larva L1    1308 larva L2    992 larva L3 12hr old    919 larva L3 puffstage 1-2    1067 larva L3 puffstage 3-6  (1957) larva L3 puffstage 7-9  (2552) white prepupae new  (2675) white prepupae 12hr  (2559) white prepupae 24hr  (3343) pupae 2d postWPP  (2111) pupae 3d postWPP  (1886) pupae 4d postWPP  (1940) adult male 01day  (1886) adult male 05day  (2366) adult male 30day  (2540) adult female 01day  (3045) adult female 05day  (4444) adult female 30day  (4504) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    9177 embryo 02-04hr    8755 embryo 04-06hr    4895 embryo 06-08hr    5358 embryo 08-10hr    4830 embryo 10-12hr    3223 embryo 12-14hr    2831 embryo 14-16hr    3631 embryo 16-18hr    2895 embryo 18-20hr    1908 embryo 20-22hr    2736 embryo 22-24hr    2105 larva L1    1308 larva L2    992 larva L3 12hr old    919 larva L3 puffstage 1-2    1067 larva L3 puffstage 3-6    1957 larva L3 puffstage 7-9    2552 white prepupae new    2675 white prepupae 12hr    2559 white prepupae 24hr    3343 pupae 2d postWPP    2111 pupae 3d postWPP    1886 pupae 4d postWPP    1940 adult male 01day    1886 adult male 05day    2366 adult male 30day    2540 adult female 01day    3045 adult female 05day    4444 adult female 30day    4504 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    9177 embryo 02-04hr    8755 embryo 04-06hr    4895 embryo 06-08hr    5358 embryo 08-10hr    4830 embryo 10-12hr    3223 embryo 12-14hr    2831 embryo 14-16hr    3631 embryo 16-18hr    2895 embryo 18-20hr    1908 embryo 20-22hr    2736 embryo 22-24hr    2105 larva L1    1308 larva L2    992 larva L3 12hr old    919 larva L3 puffstage 1-2    1067 larva L3 puffstage 3-6    1957 larva L3 puffstage 7-9    2552 white prepupae new    2675 white prepupae 12hr    2559 white prepupae 24hr    3343 pupae 2d postWPP    2111 pupae 3d postWPP    1886 pupae 4d postWPP    1940 adult male 01day    1886 adult male 05day    2366 adult male 30day    2540 adult female 01day    3045 adult female 05day    4444 adult female 30day    4504 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0003138 expression level Developmental Stage   Expression Level embryo 00-02hr    9177 embryo 02-04hr    8755 embryo 04-06hr    4895 embryo 06-08hr    5358 embryo 08-10hr    4830 embryo 10-12hr    3223 embryo 12-14hr    2831 embryo 14-16hr    3631 embryo 16-18hr    2895 embryo 18-20hr    1908 embryo 20-22hr    2736 embryo 22-24hr    2105 larva L1    1308 larva L2    992 larva L3 12hr old    919 larva L3 puffstage 1-2    1067 larva L3 puffstage 3-6    1957 larva L3 puffstage 7-9    2552 white prepupae new    2675 white prepupae 12hr    2559 white prepupae 24hr    3343 pupae 2d postWPP    2111 pupae 3d postWPP    1886 pupae 4d postWPP    1940 adult male 01day    1886 adult male 05day    2366 adult male 30day    2540 adult female 01day    3045 adult female 05day    4444 adult female 30day    4504 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (9177) embryo 02-04hr  (8755) embryo 04-06hr  (4895) embryo 06-08hr  (5358) embryo 08-10hr  (4830) embryo 10-12hr  (3223) embryo 12-14hr  (2831) embryo 14-16hr  (3631) embryo 16-18hr  (2895) embryo 18-20hr  (1908) embryo 20-22hr  (2736) embryo 22-24hr  (2105) larva L1  (1308) larva L2  (992) larva L3 12hr old  (919) larva L3 puffstage 1-2  (1067) larva L3 puffstage 3-6  (1957) larva L3 puffstage 7-9  (2552) white prepupae new  (2675) white prepupae 12hr  (2559) white prepupae 24hr  (3343) pupae 2d postWPP  (2111) pupae 3d postWPP  (1886) pupae 4d postWPP  (1940) adult male 01day  (1886) adult male 05day  (2366) adult male 30day  (2540) adult female 01day  (3045) adult female 05day  (4444) adult female 30day  (4504) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (9177) embryo 02-04hr  (8755) embryo 04-06hr  (4895) embryo 06-08hr  (5358) embryo 08-10hr  (4830) embryo 10-12hr  (3223) embryo 12-14hr  (2831) embryo 14-16hr  (3631) embryo 16-18hr  (2895) embryo 18-20hr  1908 embryo 20-22hr  (2736) embryo 22-24hr  2105 larva L1    1308 larva L2    992 larva L3 12hr old    919 larva L3 puffstage 1-2    1067 larva L3 puffstage 3-6  1957 larva L3 puffstage 7-9  (2552) white prepupae new  (2675) white prepupae 12hr  (2559) white prepupae 24hr  (3343) pupae 2d postWPP  2111 pupae 3d postWPP  1886 pupae 4d postWPP  1940 adult male 01day  1886 adult male 05day  2366 adult male 30day  (2540) adult female 01day  (3045) adult female 05day  (4444) adult female 30day  (4504) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    9177 embryo 02-04hr    8755 embryo 04-06hr    4895 embryo 06-08hr    5358 embryo 08-10hr    4830 embryo 10-12hr    3223 embryo 12-14hr    2831 embryo 14-16hr    3631 embryo 16-18hr    2895 embryo 18-20hr    1908 embryo 20-22hr    2736 embryo 22-24hr    2105 larva L1    1308 larva L2    992 larva L3 12hr old    919 larva L3 puffstage 1-2    1067 larva L3 puffstage 3-6    1957 larva L3 puffstage 7-9    2552 white prepupae new    2675 white prepupae 12hr    2559 white prepupae 24hr    3343 pupae 2d postWPP    2111 pupae 3d postWPP    1886 pupae 4d postWPP    1940 adult male 01day    1886 adult male 05day    2366 adult male 30day    2540 adult female 01day    3045 adult female 05day    4444 adult female 30day    4504 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    9177 embryo 02-04hr    8755 embryo 04-06hr    4895 embryo 06-08hr    5358 embryo 08-10hr    4830 embryo 10-12hr    3223 embryo 12-14hr    2831 embryo 14-16hr    3631 embryo 16-18hr    2895 embryo 18-20hr    1908 embryo 20-22hr    2736 embryo 22-24hr    2105 larva L1    1308 larva L2    992 larva L3 12hr old    919 larva L3 puffstage 1-2    1067 larva L3 puffstage 3-6    1957 larva L3 puffstage 7-9    2552 white prepupae new    2675 white prepupae 12hr    2559 white prepupae 24hr    3343 pupae 2d postWPP    2111 pupae 3d postWPP    1886 pupae 4d postWPP    1940 adult male 01day    1886 adult male 05day    2366 adult male 30day    2540 adult female 01day    3045 adult female 05day    4444 adult female 30day    4504 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0003138    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0003138 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult female reproductive system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval Malpighian tubules, adult heart, larval/adult salivary gland, larval trachea, inseminated spermatheca, adult male reproductive system, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Heatmap Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary no informative data Adult Testis no informative data Adult Male Accessory Gland no informative data Adult Carcass no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_01
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003138 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9181-RC;CG9181-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Ptp61F Stages(s) 1-3 Stages(s) 4-6 Stages(s) 9-10 Stages(s) 11-12
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable Ptp61Ff06926 Ptp61FLA00327 viable, with Scer\GAL4pnr-MD237 Ptp61FGD3571 Sterility Allele fertile Ptp61Ff06926 Ptp61FLA00327 Phenotype manifest in Allele
Classical Alleles ( 27 )
For All Classical Alleles Show
Allele of Ptp61F Class Mutagen Stocks Known lesion Ptp61Fc05292 piggyBac transposase 2 -- Ptp61Ff06926 piggyBac transposase 2 -- Ptp61FLA00327 P-element activity 2 -- Ptp61FB106 1 -- Ptp61FBG02243 1 -- Ptp61Fc00282 piggyBac transposase 1 -- Ptp61Fc05697 piggyBac transposase 1 -- Ptp61Fc05849 piggyBac transposase 1 -- Ptp61Fd01050 1 -- Ptp61Fd07829 P-element activity 1 -- Ptp61Fe00366 piggyBac transposase 1 -- Ptp61Ff00532 piggyBac transposase 1 -- Ptp61Ff07223 1 -- Ptp61FG8581 P-element activity 1 -- Ptp61FMB00652 1 -- Ptp61FMB00813 1 -- Ptp61FMB08823 1 -- Ptp61FMI00172 1 -- Ptp61FMI03132 1 -- Ptp61F5-HA-2445 0 -- Ptp61Fd07829-f07223 FLPase 0 Yes Ptp61Fd07943 P-element activity 0 -- Ptp61Fe01281 piggyBac transposase 0 -- Ptp61FEP826 P-element activity 0 Yes Ptp61Ff05423-d01050 FLPase 0 Yes Ptp61FMB04181 0 -- Ptp61FMI01473 0 --
Alleles Carried on Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Ptp61F Class Mutagen Stocks Known lesion Ptp61FGD3571 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Ptp61FHMS00421 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Ptp61Fa.Act5C in vitro construct - regulatory fusion 0 Yes Ptp61Fa.Scer\UAS in vitro construct - regulatory fusion 0 Yes Ptp61Fc.Act5C in vitro construct - regulatory fusion 0 Yes Ptp61Fc.Scer\UAS in vitro construct - regulatory fusion 0 Yes Ptp61FdsRNA.cCa in vitro construct - RNAi 0 Yes Ptp61FKK101883 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Ptp61FScer\UAS.cBa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)ED4238 (Baeg et al., 2005)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD3571} NA P{KK101883} NA P{TRiP.HMS00421} NA P{UAS-Ptp61F.a} NA P{UAS-Ptp61F.B} NA P{UAS-Ptp61F.c} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}312EP826 NA P{EP}Ptp61FG8581 NA P{GSV1}C865C865 NA P{Mae-UAS.6.11}Ptp61FLA00327 NA P{XP}Ptp61Fd01050 NA P{XP}Ptp61Fd07829 NA P{XP}Ptp61Fd07943 NA miscellaneous insertions Mi{MIC}Ptp61FMI00172 NA Mi{MIC}Ptp61FMI01473 NA Mi{MIC}Ptp61FMI03132 NA P{GT1}Ptp61FBG02243 NA P{RS5}Ptp61F5-HA-2445 NA PBac{5HPw+}Ptp61FB106 NA PBac{PB}312c05697 NA PBac{PB}Ptp61Fc00282 NA PBac{PB}Ptp61Fc05292 NA PBac{PB}Ptp61Fc05697 NA PBac{PB}Ptp61Fc05849 NA PBac{RB}Ptp61Fe00366 NA PBac{RB}Ptp61Fe01281 NA PBac{WH}Ptp61Ff00532 NA PBac{WH}Ptp61Ff06926 NA PBac{WH}Ptp61Ff07223 NA insertion of enhancer trap binary system Mi{ET1}CG32320MB04181 No Mi{ET1}Ptp61FMB00652 No Mi{ET1}Ptp61FMB00813 No Mi{ET1}Ptp61FMB08823 No
Gene Ontology: Function, Process & Cellular Component ( 14 unique terms )
Terms Based on Experimental Evidence ( 14 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with Abi (Huang et al., 2007) protein tyrosine phosphatase activity inferred from direct assay (McLaughlin and Dixon, 1993) inferred from direct assay AND inferred from sequence or structural similarity (McLaughlin and Dixon, 1993) inferred from mutant phenotype (Huang et al., 2007)
Biological Process
CV term Evidence References
axon guidance inferred from physical interaction with dock (Clemens et al., 1996) cellular response to hypoxia inferred from mutant phenotype (Lee et al., 2008) germ-band extension inferred from direct assay (assigned by UniProtKB) (Ursuliak et al., 1997) mitotic cell cycle inferred from mutant phenotype (Chen et al., 2007) negative regulation of peptidyl-tyrosine phosphorylation inferred from mutant phenotype (Huang et al., 2007) oogenesis inferred from direct assay (assigned by UniProtKB) (Ursuliak et al., 1997) protein dephosphorylation inferred from direct assay (McLaughlin and Dixon, 1993) regulation of protein localization inferred from direct assay (Huang et al., 2007) regulation of protein stability inferred from mutant phenotype (Huang et al., 2007)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (McLaughlin and Dixon, 1993) nucleus inferred from direct assay (McLaughlin and Dixon, 1993) perinuclear region of cytoplasm inferred from direct assay (Huang et al., 2007)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
protein tyrosine phosphatase activity non-traceable author statement (McLaughlin, 1993.5.19, Zou et al., 2000, Morrison et al., 2000)
Biological Process
CV term Evidence References
protein dephosphorylation non-traceable author statement (Morrison et al., 2000)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Ptp61F allele Gene References Ptp61Fc.Scer\UAS hop (Muller et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 63702 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0003138 DroID - A comprehensive database of gene and protein interactions. • FBgn0003138 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38160
Orthologs
Genome-wide drosophilid orthologs	Dana\GF10060 Dere\GG14603 Dgri\GH16593 Dmoj\GI12440 Dper\GL20849 Dpse\GA21595 Dsec\GM14217 Dsim\GD13480 Dvir\GJ12338 Dwil\GK16610 Dyak\GE20964
Curated drosophilid orthologs	Dpse\GA21595
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL001919-PB Aedes aegypti (mosquito) AGAP005352-PA Anopheles gambiae (mosquito) XP_392429.2 Apis mellifera (honey bee) XP_001948698.1 Acyrthosiphon pisum (pea aphid) 88737 Branchiostoma floridae (lancelet) BGIBMGA002096-PA Bombyx mori (silk worm) ENSBTAP00000008678 Bos taurus (bovine) CBP22070 Caenorhabditis briggsae (nematode) CE06525 Caenorhabditis elegans (worm) ENSCAFP00000016950 Canis familiaris (dog) ENSCINP00000016137 Ciona intestinalis (sea squirt) CPIJ011976 Culex pipens (mosquito) ENSCPOP00000001741 Cavia porcellus (guinea pig) RP33431 Caenorhabditis remanei (nematode) ENSCSAVP00000014189 Ciona savignyi (sedentary tunicate) ENSDARP00000062692 Danio rerio (zebra fish) ENSECAP00000000666 Equus caballus (horse) XP_655870 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000015646 Gymnopilus aculeatus (mushroom) ENSGALP00000022449 Gallus gallus (chicken) ENSP00000360683 Homo sapiens (human) 218669 Lottia gigantea (owl limpet) 25202 Monocosta brevicollis (choanoflagellate) ENSMODP00000020417 Monodelphis domestica (gray opossum) ENSMMUP00000010349 Macaca mulatta (rhesus monkey) ENSMUSP00000112675 Mus musculus (house mouse) XP_001603887.1 Nasonia vitripennis (wasp) ENSOANP00000004753 Ornithorynchus anatinus (platypus) ENSORLP00000003160 Oryzias latipes (japanese killifish) PHUM002237-PA Pediculus humanus (human body louse) ENSPPYP00000012433 Pongo pygmaeus (orangutan) ENSPTRP00000043532 Pan troglodytes (chimpanzee) ENSRNOP00000023763 Rattus norvegicus (norway rat) Smp_139930 Schistosoma mansoni (trematode parasite) XP_787465.2 Strongylocentrotus purpuratus (purple sea urchin) XP_969316.1 Tribolium castaneum (red flour beetle) Tc00.1047053510187.234 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000016302 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000017380 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000042578 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB10373 NV13283 LH10126 FBgn0238249 FBgn0218612 FBgn0199584 FBgn0185191 FBgn0169143 JGI_V11_207917 FBgn0081581 FBgn0158444 FBgn0135197 FBgn0124064 FBgn0106859 FBgn0087101 CPIJ011976 BGIBMGA002096 ACYPI008536 GB14529 AGAP005352 AAEL001919 PHUM581330 GLEAN_03328
Stocks & Reagents
Stocks Listed in FlyBase ( 25 )
Harvard	- P{XP}Ptp61Fd01050 - P{XP}Ptp61Fd07829 - PBac{PB}Ptp61Fc00282 - PBac{PB}Ptp61Fc05292 - PBac{PB}Ptp61Fc05697 - PBac{PB}Ptp61Fc05849 - PBac{RB}Ptp61Fe00366 - PBac{WH}Ptp61Ff00532 - PBac{WH}Ptp61Ff06926 - PBac{WH}Ptp61Ff07223
VDRC	v37436 w1118; P{GD3571}v37436 v37437 w1118; P{GD3571}v37437/TM3
	More stocks available...
Genomic Clones ( 2 )
	BACR17K17 BACR27O01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 242 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GM09783 LP01280 LP02164 RE73935
Other clones	DPiM_LP01280
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT10282 AT14029 AT14033 AT18821 AT19269 AT20426 AT20873 AT28161 AT31981 GH07203 GH26214 HL01022 HL01331 HL01534 LD08378 LD10932 LD13842 LD16615 LD22541 LD22735 LD22743 LD24480 LD26937 LD30440 LD31179 LD32012 LD37180 LD37465 LD37740 LD38107 LD39771 LD43436 LD43526 LD44050 LD44468 LD44974 LD46183 LD46316 LD46748 LD46759 LD46771 LD46772 LD47194 LD47476 LD47685 LD47707 LP04519 RE03330 RE03988 RE04875 RE07716 RE08593 RE12493 RE14680 RE14948 RE15435 RE15780 RE16167 RE19694 RE21856 RE22274 RE22367 RE25610 RE26057 RE30462 RE30961 RE32854 RE33760 RE34388 RE34895 RE36191 RE36292 RE36528 RE37302 RE38450 RE38550 RE40558 RE40607 RE42176 RE44844 RE46178 RE46319 RE46406 RE46907 RE48366 RE49495 RE49652 RE51395 RE57553 RE57761 RE60358 RE61104 RE62285 RE63701 RE64344 RE64486 RE65760 RE65959 RE66455 RE68511 RE68867 RE69721 RE70867 RE71566 RE72314 RE73258 RE73353 RE73436 RE73492 RE74302 RE74405 RE74695 RE74908 RH02041 RH04810 RH04851 RH05833 RH08030 RH15080 RH18014 RH35086 RH42109 RH43122 RH52737 RH57536 RH61331 RH62408 RH63639 RH64663 RH66446 RH74613 SD02289 SD03350 SD03405 SD05138 SD12520 SD13664 SD13735 SD25386
Other clones	10975 33982 43839 58041 59973 69655 70993 101272 102542 107796 160506 163202 175210 177599 177770 181429 193197 214407.24 522129 CK01.50D.A2 CK01.59A.D11 Dmel_neb_001006_0110_3648 Dmel_neb_015829_0339_2113 EC052157 EC052646 EC052647 EC053146 EC053147 EC054824 EC055680 EC056092 EC056402 EK041733 EK047912 EK060807 EK146515 EK159215 EK177507 EK199017 EK225635 EK234243 EK243561 EK263543 EK267223 EK279210 EK282632 EK287135 EK296426 EN01426 EP03203 EP04458 EP08464 ESG015d.E21.1_E11 FGM101B06 GM12509 IP03335 LD15970 LD30437 LD35034 RE01370 RE01571 RE04848 RE19940 RE25616 RE40162 RE57187 RE66502 RE69865 RP001020125 RP004005743 RP004006540 RP004041211 RP004065308 RP004074107 RP004120129 RP004140453 RP004190710 RP004215384 RP004215648 RP004217266 RP004218860 RP004222947 RP004227269 RP004252192 RP004256331 RP004258280 RP004290124 RP004306373 RP004324709 RP004336515 RP004383956 RP004412955 RP004440131 RP004500089 RP004508263 RP004535179 RP004558000 SD05388
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0003138 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38160
Antibody Information
	polyclonal (Clemens et al., 1996, McLaughlin and Dixon, 1993, McLaughlin and Dixon, 1993)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Ptp61F anon-WO0140519.98 anon-WO0118547.297 (FlyBase, 1996-) Source for merge of: Ptp61F BEST:LP01280 (FlyBase, 1996-) Source for merge of: Ptp61F CG9178 (FlyBase, 1996-)
Additional comments	Source for merge of Ptp61F BEST:LP01280 was a shared cDNA (date:030206). (FlyBase, 1996-) Source for merge of Ptp61F anon-WO0140519.98 anon-WO0118547.297 was sequence comparison (date:051113). (FlyBase, 1996-) Release 1 annotation CG9178 corresponds to part of release 3.2 annotation CG9181 (which is Ptp61F). (FlyBase, 1996-)
Other Comments
	Ptp61F negatively regulates JAK/STAT signaling and is also a transcriptional target of JAK/STAT signaling. (Baeg et al., 2005) S2-derived S2-NP cells treated with dsRNA made from templates generated with primers directed against Ptp61F experience a more than four-fold increase in Stat92E-dependent reporter activity and a significant increase in Stat92E phosphorylation. dsRNA knock-down also results in a dramatic increase in tyrosine phosphorylation of hop protein. (Baeg et al., 2005) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Area matching Drosophila EST AA567483 (inverted). (Davies, 2001.3.15) The spatial and temporal expression of two alternative transcripts of Ptp61F during Drosophila embryogenesis has been analysed in wild-type embryos and in embryos mutant for pair-rule and segment-polarity genes. (Ursuliak et al., 1997) Spatial and temporal transcript accumulation pattern in ovaries is determined by in situ hybridisation. (Fitzpatrick et al., 1995) Two 3' splice variants of this gene generate two proteins that differ in their C-termini. One is targeted to the cytoplasmic membrane, the other to the nucleus. (McLaughlin and Dixon, 1993)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057339 NM_057340 NM_167874 NM_167875 RefSeq (Proteins) • NP_476687 NP_476688 NP_728600 NP_728601 DDBJ / EMBL / GenBank • AA567483 AAA28748 AAA75338 AAA75339 AAA75348 AAA75349 AAF47486 AAF47487 AAL39858 AAN11475 AAN11476 AC004489 AC005847 AI258156 AW943967 AX094173 AX154749 AY069713 CZ466343 CZ469851 CZ470193 CZ470300 CZ475944 CZ476005 CZ478262 CZ479087 CZ482995 CZ489663 CZ489664 DU708629 L11249 L11250 L11251 L11252 L11253 L14849 Entrez Gene - A searchable database of RefSeq genes. • 38160 UniProtKB/Swiss-Prot • Q9W0G1 UniProtKB/TrEMBL • Q8IRH4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein-tyrosine phosphatase, receptor/non-receptor type (IPR000242) Protein-tyrosine/Dual-specificity phosphatase (IPR000387) Protein-tyrosine phosphatase, non-receptor type-1, -2 (IPR012265) Protein-tyrosine phosphatase, active site (IPR016130)
Linkouts
	BioGRID - A database of protein and genetic interactions • 63702 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0003138 DroID - A comprehensive database of gene and protein interactions. • FBgn0003138 DRSC - Results from RNAi screens. • FBgn0003138 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003138 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9181-RC;CG9181-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0003138 FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways • 415769 152593 152594 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38160 InParanoid A subset of ortholog calls from InParanoid. • AAEL001919-PB Aedes aegypti (mosquito) AGAP005352-PA Anopheles gambiae (mosquito) XP_392429.2 Apis mellifera (honey bee) XP_001948698.1 Acyrthosiphon pisum (pea aphid) 88737 Branchiostoma floridae (lancelet) BGIBMGA002096-PA Bombyx mori (silk worm) ENSBTAP00000008678 Bos taurus (bovine) CBP22070 Caenorhabditis briggsae (nematode) CE06525 Caenorhabditis elegans (worm) ENSCAFP00000016950 Canis familiaris (dog) ENSCINP00000016137 Ciona intestinalis (sea squirt) CPIJ011976 Culex pipens (mosquito) ENSCPOP00000001741 Cavia porcellus (guinea pig) RP33431 Caenorhabditis remanei (nematode) ENSCSAVP00000014189 Ciona savignyi (sedentary tunicate) ENSDARP00000062692 Danio rerio (zebra fish) ENSECAP00000000666 Equus caballus (horse) XP_655870 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000015646 Gymnopilus aculeatus (mushroom) ENSGALP00000022449 Gallus gallus (chicken) ENSP00000360683 Homo sapiens (human) 218669 Lottia gigantea (owl limpet) 25202 Monocosta brevicollis (choanoflagellate) ENSMODP00000020417 Monodelphis domestica (gray opossum) ENSMMUP00000010349 Macaca mulatta (rhesus monkey) ENSMUSP00000112675 Mus musculus (house mouse) XP_001603887.1 Nasonia vitripennis (wasp) ENSOANP00000004753 Ornithorynchus anatinus (platypus) ENSORLP00000003160 Oryzias latipes (japanese killifish) PHUM002237-PA Pediculus humanus (human body louse) ENSPPYP00000012433 Pongo pygmaeus (orangutan) ENSPTRP00000043532 Pan troglodytes (chimpanzee) ENSRNOP00000023763 Rattus norvegicus (norway rat) Smp_139930 Schistosoma mansoni (trematode parasite) XP_787465.2 Strongylocentrotus purpuratus (purple sea urchin) XP_969316.1 Tribolium castaneum (red flour beetle) Tc00.1047053510187.234 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000016302 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000017380 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000042578 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38160 modMine - Data generated by the modENCODE project. • FBgn0003138 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB10373 NV13283 LH10126 FBgn0238249 FBgn0218612 FBgn0199584 FBgn0185191 FBgn0169143 JGI_V11_207917 FBgn0081581 FBgn0158444 FBgn0135197 FBgn0124064 FBgn0106859 FBgn0087101 CPIJ011976 BGIBMGA002096 ACYPI008536 GB14529 AGAP005352 AAEL001919 PHUM581330 GLEAN_03328
Synonyms & Secondary IDs ( 16 )
Reported As
Symbol Synonym	anon-WO0118547.297   anon-WO0140519.98   BEST:LP01280   CG9178   CG9181 (Morrison et al., 2000, Molnar et al., 2006, Lee et al., 2008, Keleman et al., 2009.8.5, Ni et al., 2010.12.1) DPTP61F (Muda et al., 2002, Clemens et al., 2000, den Hertog, 1999, Stoker and Dutta, 1998, Ursuliak et al., 1997, Nieto, 1996, Ursuliak et al., 1996, Fitzpatrick et al., 1995) dPTP61F (Walchli et al., 2000, Garcia-Alonso, 1999, McCarty, 1998, Clemens et al., 1996, McLaughlin and Dixon, 1993, Erfurth and Schmucker, 2008) dptp61F (Ursuliak et al., 1997) PTP61F (Baeg et al., 2005, Kung, 1993, Gotea and Makalowski, 2006, Huang et al., 2007, Arbouzova and Zeidler, 2006, Perrimon and Mathey-Prevot, 2007, Huang et al., 2007) ptp61F (Muller, 2005, Arbouzova and Zeidler, 2006, Wright et al., 2011) Ptp61F (Chen et al., 2007, Baeg et al., 2007, Molnar et al., 2006, Bakal et al., 2008, Lee et al., 2008, Lipatov et al., 2005, Hilger et al., 2009, Wei et al., 2003, Yu et al., 2010) R-PTP 61F (Morrison et al., 2000)
Name Synonym	protein tyrosine phosphatase (McLaughlin, 1993.5.19, McLaughlin, 1993.5.19, McLaughlin, 1993.5.19, McLaughlin, 1995.9.13, McLaughlin, 1993.5.19) protein-tyrosine-phosphatase (Zou et al., 2000) Protein tyrosine phosphatase 61F   protein tyrosine phosphatase 61F (Lee et al., 2008)
Secondary FlyBase IDs
	FBgn0035219 FBgn0043788 FBgn0044527 FBgn0062112
References ( 78 )
Generate a list of	All references relating to this gene ( 78 )
List References by type	Research paper  ( 23 ) Supplementary material  ( 6 ) Review  ( 7 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 17 ) Abstract  ( 5 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 7 ) Conference report  ( 1 ) Patent  ( 2 ) Computer file  ( 4 ) Curated genome annotation  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 3 )
	Horn et al., 2011, Nat. Methods 8(4): 341--346 Mapping of signaling networks through synthetic genetic interaction analysis by RNAi. [FBrf0213352] Wright et al., 2011, Cell. Signal. 23(5): 920--927 Differential activities of the Drosophila JAK/STAT pathway ligands Upd, Upd2 and Upd3. [FBrf0213113] Yu et al., 2010, PLoS Genet. 6(5): e1000969 Affecting Rhomboid-3 function causes a dilated heart in adult Drosophila. [FBrf0210954] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...