FlyBase Gene Report: Dmel\PpY-55A

General Information

Symbol

Dmel\PpY-55A

Species

D. melanogaster

Name

Protein phosphatase Y at 55A

Annotation Symbol

CG10930

Feature Type

protein_coding_gene

FlyBase ID

FBgn0003140

Gene Model Status

Current

Stock Availability

8 publicly available

Enzyme Name (EC)

protein-serine/threonine phosphatase (3.1.3.16)

Gene Summary

Protein phosphatase Y at 55A (PpY-55A) encodes a male serine/threonine phosphatase expressed in testis somatic cells. [Date last reviewed: 2019-08-01] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

PPY, PPY 55A

Key Links

Genomic Location

Cytogenetic map

55A2-55A2

Sequence location

2R:17,955,396..17,956,570 [-]

Recombination map

2-84

RefSeq locus

NT_033778 REGION:17955396..17956570

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (4 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables protein serine/threonine phosphatase activity

inferred from direct assay

(Kokai et al., 2006, Armstrong et al., 1995)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables hydrolase activity

inferred from electronic annotation with InterPro:IPR004843, InterPro:IPR006186

(InterPro Project Members, 2004-)

enables protein serine/threonine phosphatase activity

inferred from biological aspect of ancestor with PANTHER:PTN000185233

(GO Reference Genome Project, 2011-)

Biological Process (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(Armstrong et al., 1995)

located_in nucleus

inferred from direct assay

(Kokai et al., 2006, Armstrong et al., 1995)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN000185233

(GO Reference Genome Project, 2011-)

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN000185231

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

PPP FAMILY PROTEIN SERINE/THREONINE PHOSPHATASES

Protein Family (UniProt)

Belongs to the PPP phosphatase family. PP-Y subfamily. (P11612)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

protein serine/threonine phosphatase activity

(1) O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate (3.1.3.16)

(2) O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate (3.1.3.16)

Summaries

Gene Snapshot

Protein phosphatase Y at 55A (PpY-55A) encodes a male serine/threonine phosphatase expressed in testis somatic cells. [Date last reviewed: 2019-08-01]

Gene Group (FlyBase)

PPP FAMILY PROTEIN SERINE/THREONINE PHOSPHATASES -: The Phosphoprotein Phosphatase (PPP) family members are serine/threonine phosphatases. They often function in association with regulatory subunits. (Adapted from PMID:11230548 and PMID:19879837).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\PpY-55A for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry P11612)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.50

Gene model reviewed during 5.55

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

PpY-55A-RA

FBtr0086817

NM_057341

1175

314

PpY-55A-RB

FBtr0344898

NM_001299625

1082

314

Additional Transcript Data and Comments

Reported size (kB)

1.4 (northern blot)

(Armstrong et al., 1995)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

PpY-55A-PA

FBpp0085996

36.0

314

6.28

FBpp0311209

36.0

314

6.28

P11612

NP_001286554

AHN56350

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

314 aa isoforms: PpY-55A-PA, PpY-55A-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

314 (aa); 36 (kD predicted)

(Dombradi et al., 1989)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\PpY-55A using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

PpY-55A_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

5.03

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | male

testis

(Adám et al., 2010)

cyst cell of testis

(Adám et al., 2010)

primary spermatocyte

(Adám et al., 2010)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

pupal stage

(Armstrong et al., 1995)

spermatogenesis & adult stage

testis

(Armstrong et al., 1995)

Additional Descriptive Data

In situ analysis of male adults shows that expression of PpY-55A transcript is testis-specific.

(Adám et al., 2010)

PpY-55A transcripts are detected in males, pupae and at a low level in larvae. They are detected in testes in larvae and males but not in the carcasses from which the gonads were removed.

(Armstrong et al., 1995)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage

cyst cell of testis

(Armstrong et al., 1995)

larval stage & spermatogenesis

testis

(Armstrong et al., 1995)

spermatogenesis & adult stage

testis

(Armstrong et al., 1995)

cyst cell of testis

(Armstrong et al., 1995)

Additional Descriptive Data

PpY-55A protein is detected only in extracts from testis on western blots. Immunolocalization studies demonstrate that it is found predominantly in the nuclei of cells distributed along the length of the testis. Staining is weak in the apical region. Colocalization studies with an enhancer trap marker line show that the site of PpY-55A protein expression is the cyst cells.

(Armstrong et al., 1995)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(Armstrong et al., 1995)

located_in nucleus

inferred from direct assay

(Kokai et al., 2006, Armstrong et al., 1995)

Expression Deduced from Reporters

Reporter: P{PpY-55A-GAL4.J}

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | male

cyst cell of testis

(Rotkopf et al., 2011)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\PpY-55A in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\PpY-55A

View exonic expression by tissue for Dmel\PpY-55A

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0003140

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

48532/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0003140

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0003140

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0003140

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG10930

Flygut - An atlas of the Drosophila adult midgut

FBgn0003140

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 0 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 5 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of PpY-55A

Transgenic constructs containing regulatory region of PpY-55A

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 5 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

PpY-55A^GD7130

viable, with Scer\GAL4^Mef2.PR

PpY-55A^GD7130

viable, with Scer\GAL4^pnr-MD237

PpY-55A^GD7130

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (13)

Hsap\PPP1CA

8 of 14

Yes

7 of 14

5 of 14

4 of 14

4 of 14

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (14)

Rnor\Ppp1ca

8 of 14

Yes

7 of 14

5 of 14

4 of 14

4 of 14

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Mus musculus (laboratory mouse) (14)

Mmus\Ppp1ca

8 of 14

Yes

6 of 14

5 of 14

4 of 14

4 of 14

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (13)

Xtro\ppp1cc

6 of 13

Yes

4 of 13

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (18)

Drer\ppp1caa

7 of 14

Yes

Drer\ppp1cab

7 of 14

Yes

Drer\ppp1cc

7 of 14

Yes

5 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (47)

Cele\C06A1.3

7 of 14

Yes

Cele\C25A6.1

7 of 14

Yes

Cele\C47A4.3

7 of 14

Yes

Cele\F25B3.4

7 of 14

Yes

Cele\F58G1.3

7 of 14

Yes

Cele\gsp-2

7 of 14

Yes

Cele\ZK938.1

7 of 14

Yes

Cele\C23G10.1

6 of 14

Yes

Cele\F22D6.9

6 of 14

Yes

Cele\F23B12.1

6 of 14

Yes

Cele\F52H3.6

6 of 14

Yes

Cele\pph-1

6 of 14

Yes

Cele\T25B9.2

6 of 14

Yes

Cele\Y69E1A.4

6 of 14

Yes

Cele\Y71G12B.30

6 of 14

Yes

Cele\ZK354.9

6 of 14

Yes

Cele\C09H5.7

5 of 14

Yes

Cele\C24H11.1

5 of 14

Yes

Cele\C24H11.2

5 of 14

Yes

Cele\C30A5.4

5 of 14

Yes

Cele\C34D4.2

5 of 14

Yes

Cele\F26B1.5

5 of 14

Yes

Cele\F42G8.8

5 of 14

Yes

Cele\F49E11.7

5 of 14

Yes

Cele\gsp-3

5 of 14

Yes

Cele\gsp-4

5 of 14

Yes

Cele\R13A5.11

5 of 14

Yes

Cele\T16G12.7

5 of 14

Yes

Cele\ZC477.2

5 of 14

Yes

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

Yes

Cele\R08C7.8

4 of 14

Yes

Cele\Y40H4A.2

4 of 14

Yes

Cele\C27B7.6

3 of 14

Yes

Cele\F44B9.9

3 of 14

Yes

Cele\pph-4.2

3 of 14

Cele\R03D7.8

3 of 14

Yes

Cele\W03D8.2

3 of 14

Yes

Cele\F20D6.6

2 of 14

Yes

Cele\F40E3.5

2 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (8)

Agam\AgaP_AGAP011166

6 of 12

Yes

5 of 12

5 of 12

4 of 12

4 of 12

3 of 12

3 of 12

2 of 12

Arabidopsis thaliana (thale-cress) (32)

Atha\TOPP3

7 of 13

Yes

Atha\TOPP7

7 of 13

Yes

Atha\TOPP4

6 of 13

Atha\TOPP6

6 of 13

Atha\TOPP8

6 of 13

Yes

Atha\TOPP9

6 of 13

Yes

5 of 13

5 of 13

5 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

3 of 13

Yes

Atha\BSL2

3 of 13

Yes

Atha\BSL3

3 of 13

Yes

Atha\BSU1

3 of 13

Yes

3 of 13

3 of 13

3 of 13

3 of 13

Yes

2 of 13

2 of 13

2 of 13

1 of 13

Yes

Atha\AT3G09970

1 of 13

Yes

Atha\SGT1A

1 of 13

Atha\SGT1B

1 of 13

Atha\SLP1

1 of 13

Yes

Atha\SLP2

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (13)

Scer\GLC7

6 of 13

Yes

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

2 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (11)

Spom\dis2

6 of 12

Yes

5 of 12

4 of 12

4 of 12

4 of 12

Yes

3 of 12

3 of 12

3 of 12

3 of 12

2 of 12

1 of 12

Yes

Escherichia coli (enterobacterium) (3)

Ecol\pphA

2 of 11

Yes

Ecol\pphB

2 of 11

Yes

Ecol\apaH

1 of 11

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:PpY-55A. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (18)

flw

6 of 13

6 of 13

6 of 13

6 of 13

6 of 13

6 of 13

6 of 13

mts

5 of 13

5 of 13

5 of 13

5 of 13

4 of 13

PpV

4 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PPP1CA; protein phosphatase 1 catalytic subunit alpha

8 of 14

176875

PPP1CC; protein phosphatase 1 catalytic subunit gamma

7 of 14

176914

PPP1CB; protein phosphatase 1 catalytic subunit beta

5 of 14

600590

NOONAN SYNDROME-LIKE DISORDER WITH LOOSE ANAGEN HAIR 2; NSLH2

Noonan syndrome-like disorder with loose anagen hair 2

PPP2CA; protein phosphatase 2 catalytic subunit alpha

4 of 14

176915

HOUGE-JANSSENS SYNDROME 3; HJS3

PPP2CB; protein phosphatase 2 catalytic subunit beta

4 of 14

176916

PPP4C; protein phosphatase 4 catalytic subunit

4 of 14

602035

PPP6C; protein phosphatase 6 catalytic subunit

4 of 14

612725

PPEF1; protein phosphatase with EF-hand domain 1

3 of 14

300109

PPEF2; protein phosphatase with EF-hand domain 2

3 of 14

602256

PPP3CA; protein phosphatase 3 catalytic subunit alpha

3 of 14

114105

developmental and epileptic encephalopathy 91

PPP3CB; protein phosphatase 3 catalytic subunit beta

3 of 14

114106

PPP3CC; protein phosphatase 3 catalytic subunit gamma

3 of 14

114107

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

PpY-55A - PPYR1

two hybrid

(Kerekes et al., 2014)

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Acn

suppressible

PpY-55A

(Nandi et al., 2022)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0003140

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

mRNA surveillance pathway

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

P11612

Class of Gene

nuclear_gene

protein_coding_gene

retrogene

(dos Santos, 2014, Miskei et al., 2011, Dai et al., 2006)

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-84

Cytogenetic map

55A2-55A2

Sequence location

2R:17,955,396..17,956,570 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

55A2-55A2

Limits computationally determined from genome sequence between P{PZ}grh⁰⁶⁸⁵⁰&P{lacW}olf186-F^k11505 and P{PZ}Hsf⁰³⁰⁹¹&P{EP}Dgp-1^EP731

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

55A1-55A3

(determined by in situ hybridisation)

(Dombradi et al., 1989)

Experimentally Determined Recombination Data

Location

2-84

(FlyBase, 2016)

2-88.0

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (8)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

74255

w¹¹¹⁸; P{VT018472-p65.AD}attP40

74177

w¹¹¹⁸; P{VT018472-GAL4.DBD}attP2

57519

y¹ sc^* v¹ sev²¹; P{TRiP.HMC04834}attP40

Korea

14924

P{VT018472-GAL4}attP2

NIG-Fly

2RG-0568

y² VhaAC39-1^cho-1 v¹; P{U6-PpY-55A.NIG.sgRNA}attP40/CyO

VDRC

v102021

P{KK110377}VIE-260B

v16096

w¹¹¹⁸; P{GD7130}v16096

v342312

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD02057}attP40/CyO-GFP

Genomic Clones (21)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (8)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

AT05565

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0003140

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0003140

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Armstrong et al., 1995)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

PpY-55A is a testis specific protein phosphatase with biochemical properties distinct from rabbit PP1. Localisation of PpY-55A to somatic cyst cells in testis indicates the protein may be important for differentiation of mature spermatozoa.

(Armstrong et al., 1995)

Isolated from a Drosophila head cDNA library, using a rabbit serine/threonine-specific protein phosphatase (PP-1) cDNA fragment as a probe.

(Dombradi et al., 1989)

A PpY-55A cDNA has been cloned and sequenced.

(Dombradi et al., 1989)

Relationship to Other Genes

Source for database merge of

Source for merge of: PpY-55A CG10930

(Bayraktaroglu, 2000.4.13)

Source for merge of: PpD19 CG10930

(Misra, 2000.7.28)

Additional comments

The PpY-55A gene may have been derived from a related phosphoprotein phosphatase gene by retroposition and subsequent tandem duplication.

(Miskei et al., 2011)

The PpY-55A gene may have been derived from the flw gene by retroposition.

(Dai et al., 2006)

PpY-55A and adp are different genes.

(Doane, 1999)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

CG10930

(National Institute of Genetics Fly Stocks, 2022-, Hosono et al., 2015, Kerekes et al., 2014, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Dai et al., 2006, Morrison et al., 2000)

D19

(Chen et al., 1992)

DmPpY-55A

(Cohen et al., 2005)

PPY

(Kokai et al., 2006, Morrison et al., 2000, Helps et al., 1998, Helps et al., 1998, Armstrong et al., 1995, Cohen et al., 1990)

PPY 55A

(Morrison et al., 2000, Armstrong et al., 1998, Cohen, 1997, Chen et al., 1992)

PpD19

PpY-55A

(Cridland et al., 2023, Ostalé et al., 2021, dos Santos, 2014, Miskei et al., 2011, Adám et al., 2010)

Name Synonyms

Protein phosphatase D19

Protein phosphatase Y at 55A

protein phosphatase from PCR fragment D19

(Chen, 1993.1.7)

protein phosphatase-Y

(Dombradi et al., 1989)

Secondary FlyBase IDs

FBgn0005781
FBgn0034285

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

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External Crossreferences and Linkouts ( 41 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

48532

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

P11612

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P11612

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

A0A0B4LFR7

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

P11612

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0003140

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

48532/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0003140

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0003140

FlyMine - An integrated database for Drosophila genomics

FBgn0003140

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG10930

MARRVEL_MODEL - MARRVEL (model organism gene)

48532

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0003140

DroID - A comprehensive database of gene and protein interactions.

FBgn0003140

DRSC - Results frm RNAi screens

FBgn0003140

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

PpY-55A_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0003140

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0003140

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG10930

Flygut - An atlas of the Drosophila adult midgut

FBgn0003140

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

mRNA surveillance pathway

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

P11612

References (57)

The following external sites may use different assemblies or annotations than FlyBase.

5.03

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