PM/mPM, l(3)10631, mPM, Para, miniparamyosin
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.46
Gene model includes transcripts encoding non-overlapping portions of the full CDS.
Gene model reviewed during 5.48
Heterodimer of two isoforms.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Prm using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Prm in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Relative amounts of Prm and miniparamyosin are different in different muscle types. The pattern of Prm and miniparamyosin isoforms changes with the maturation of adult musculature. Miniparamyosin has a possible role in the sequential transition of nonfunction to functional muscle, in general, while Prm transition is more specifically related to the onset of function in thoracic flight muscles.
Alternate promoter selection of Prm generates two polypeptides, standard paramyosin and mini-paramyosin.
The 60kD miniparamyosin isoform is encoded by the Prm gene. The 5' flanking regions of the Dvir\Prm gene and the D.melanogaster Prm gene have been sequenced and compared to try to identify any evolutionarily conserved sequences.
A number of Prm cDNAs have been cloned and sequenced, and its RNA expression pattern has been analysed. The Prm gene encodes two forms of Prm protein, "standard paramyosin" and "miniparamyosin", which share the same 363 carboxy-terminal amino acids, but differ in their amino terminal regions.