FB2019_06, released Dec 19, 2019

Gene: Dmel\put

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General Information
Symbol
Dmel\put
Species
D. melanogaster
Name
punt
Annotation Symbol
CG7904
Feature Type
protein_coding_gene
FlyBase ID
FBgn0003169
Gene Model Status
Current
Stock Availability
15 publicly available
Gene Snapshot
punt (put) encodes a transforming growth factor beta type II receptor that functions in both Dpp/BMP and Activin signaling. Pathway specificity in signaling output is determined by which type I receptor (Dpp/BMP or Activin one) is engaged in the complex with the product of put. [Date last reviewed: 2019-03-14]
Other Summaries
Also Known As
Atr-II, l(3)10460, TGF-β
Key Links
Genomic Location
Cytogenetic map
88C9-88C9
Sequence location
3R:14,619,030..14,625,703 [-]
Recombination map
3-55
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Pathway (FlyBase)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
activin binding; activin receptor activity, type II; activin-activated receptor activity; contributes_to BMP binding; BMP receptor activity; transforming growth factor beta-activated receptor activity
Predictions / Assertions
activin binding; activin-activated receptor activity; ATP binding; protein serine/threonine kinase activity
Summaries
Pathway (FlyBase)
BMP Signaling Pathway Core Components -
The Bone Morphogenetic Protein (BMP) signaling pathway is one of two branches of Transforming Growth Factor-β family signaling in Drosophila. The binding of a BMP family dimer to a heterodimeric serine/threonine kinase receptor complex results in the phosphorylation of Mad, a member of the Smad family. Mad forms a complex with the co-Smad, Med. This complex translocates into the nucleus and regulates the transcription of target genes in concert with other nuclear cofactors. (Adapted from FBrf0236482.)
Activin Signaling Pathway Core Components -
The activin signaling pathway is one of two branches of Transforming Growth Factor-β family signaling in Drosophila. The binding of an activin family dimer to a heterodimeric serine/threonine kinase receptor complex results in the phosphorylation of Smox, a members of the Smad family. Smox forms a complex with the co-Smad, Med. This complex translocates into the nucleus and regulates the transcription of target genes in concert with other nuclear cofactors. (Adapted from FBrf0236482.)
Gene Group (FlyBase)
TGF-BETA TYPE II RECEPTORS -
The Transforming Growth Factor-β Receptor (TGF-βR) family are transmembrane serine/threonine kinases. They form heterodimeric receptor complexes composed of type I and type II subunits. Upon ligand binding, the constitutively active type II receptor phosphorylates the type I receptor which, in turn, phosphorylates a member of the Smad family. (Adapted from FBrf0236482.)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
put: punt
Homozygous lethal in embryo. Dorsal part of embryo open.
Summary (Interactive Fly)
receptor for Dpp - type II TGFß receptor - functions in both Dpp/BMP and Activin signaling - mutants lack and expression in the visceral mesoderm and fail to induce in the adjacent endodermal cells - pathway specificity in signaling output is determined by which type I receptor (Dpp/BMP or Activin one) is engaged in the complex with Put
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
2

Please see the GBrowse view of Dmel\put or the JBrowse view of Dmel\put for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.44
Stop-codon suppression (UAG) postulated; FBrf0216885.
gene_with_stop_codon_read_through ; SO:0000697
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.46
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Sequence Ontology: Class of Gene
gene_with_stop_codon_read_through
(Jungreis, 2011.11.18)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
put-RA
FBtr0082977
NM_169591
2713
516
put-RB
FBtr0330227
NM_001275646
2713
520
put-RC
FBtr0334030
NM_001275645
4013
516
Additional Transcript Data and Comments
Reported size (kB)
2.7 (unknown)
(Ruberte et al., 1995)
2.7 (northern blot)
(Childs et al., 1993)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
put-PA
FBpp0082436
58.6
516
6.74
NP_731926
AAF55079
put-PB
FBpp0303260
59.2
520
6.91
NP_001262575
AGB95956
put-PC
FBpp0306147
58.6
516
6.74
NP_001262574
AGB95955
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

516 aa isoforms: put-PA, put-PC
Additional Polypeptide Data and Comments
Reported size (kDa)
516 (aa)
(Ruberte et al., 1995, Childs et al., 1993)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\put using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Gene Ontology (36 terms)
Molecular Function (8 terms)
Terms Based on Experimental Evidence (6 terms)
CV Term
Evidence
References
activin binding
inferred from direct assay
(Lee-Hoeflich et al., 2005, Wrana et al., 1994, Childs et al., 1993)
activin receptor activity, type II
inferred from direct assay
(Childs et al., 1993)
inferred from mutant phenotype
(Jensen et al., 2009, Gesualdi and Haerry, 2007)
activin-activated receptor activity
inferred from direct assay
(Das et al., 1999, Childs et al., 1993)
contributes_to BMP binding
inferred from direct assay
(Letsou et al., 1995)
BMP receptor activity
inferred from mutant phenotype
(Gesualdi and Haerry, 2007, Shimmi et al., 2005, Shimmi and O'Connor, 2003)
inferred from direct assay
(Anderson and Wharton, 2017, Jensen et al., 2009, Shimmi et al., 2005, Inoue et al., 1998)
transforming growth factor beta-activated receptor activity
inferred from genetic interaction with FLYBASE:dpp; FB:FBgn0000490
(Ruberte et al., 1995)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
activin binding
inferred from biological aspect of ancestor with PANTHER:PTN001147373
(assigned by GO_Central )
(Gaudet et al., 2011)
activin-activated receptor activity
inferred from biological aspect of ancestor with PANTHER:PTN001147373
(assigned by GO_Central )
(Gaudet et al., 2011)
ATP binding
inferred from electronic annotation with InterPro:IPR000333, InterPro:IPR000719
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
protein serine/threonine kinase activity
inferred from biological aspect of ancestor with PANTHER:PTN000583675
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (24 terms)
Terms Based on Experimental Evidence (19 terms)
CV Term
Evidence
References
activin receptor signaling pathway
inferred from mutant phenotype
(Chng et al., 2014, Jensen et al., 2009)
inferred from direct assay
(Gesualdi and Haerry, 2007, Parker et al., 2006, Brummel et al., 1999, Das et al., 1999)
inferred from genetic interaction with FLYBASE:wit; FB:FBgn0024179
(Zheng et al., 2003)
axon guidance
inferred from mutant phenotype
(Parker et al., 2006, Serpe and O'Connor, 2006)
BMP signaling pathway
inferred from mutant phenotype
(Fuentes-Medel et al., 2012, Gesualdi and Haerry, 2007, Shimmi et al., 2005, Shimmi et al., 2005, Shimmi and O'Connor, 2003, Haerry et al., 1998, Letsou et al., 1995, Ruberte et al., 1995)
inferred from genetic interaction with FLYBASE:tkv; FB:FBgn0003716
(Nellen et al., 1996)
inferred from direct assay
(Anderson and Wharton, 2017, Jensen et al., 2009, Das et al., 1998, Inoue et al., 1998)
inferred from genetic interaction with FLYBASE:dpp; FB:FBgn0000490
(Ruberte et al., 1995)
inferred from genetic interaction with FLYBASE:sax; FB:FBgn0003317
(Letsou et al., 1995)
cellular response to glucose stimulus
inferred from mutant phenotype
(Chng et al., 2014)
dorsal closure
inferred from mutant phenotype
(Serpe and O'Connor, 2006, Riesgo-Escovar and Hafen, 1997, Letsou et al., 1995)
dorsal/ventral pattern formation
inferred from mutant phenotype
(Letsou et al., 1995)
inferred from genetic interaction with FLYBASE:dpp; FB:FBgn0000490
(Ruberte et al., 1995)
germ-line stem cell division
inferred from mutant phenotype
(Xie and Spradling, 1998)
germ-line stem cell population maintenance
inferred from mutant phenotype
(Xie and Spradling, 1998)
glucose homeostasis
inferred from mutant phenotype
(Song et al., 2017)
head involution
inferred from mutant phenotype
(Serpe and O'Connor, 2006, Letsou et al., 1995)
imaginal disc-derived wing morphogenesis
inferred from genetic interaction with FLYBASE:tkv; FB:FBgn0003716
(Nellen et al., 1996)
Malpighian tubule morphogenesis
inferred from mutant phenotype
(Jack and Myette, 1999)
neuron development
inferred from mutant phenotype
(Zheng et al., 2006)
open tracheal system development
inferred from mutant phenotype
(Myat et al., 2005)
positive regulation of neuromuscular junction development
inferred from mutant phenotype
(Fuentes-Medel et al., 2012)
positive regulation of SMAD protein signal transduction
inferred from direct assay
(Das et al., 1998)
primary branching, open tracheal system
inferred from mutant phenotype
(Ribeiro et al., 2002)
R8 cell fate specification
inferred from mutant phenotype
(Wells et al., 2017)
wing disc pattern formation
inferred from mutant phenotype
(Haerry et al., 1998)
Terms Based on Predictions or Assertions (7 terms)
CV Term
Evidence
References
activin receptor signaling pathway
inferred from biological aspect of ancestor with PANTHER:PTN001147373
(assigned by GO_Central )
(Gaudet et al., 2011)
cellular response to growth factor stimulus
inferred from biological aspect of ancestor with PANTHER:PTN000583675
(assigned by GO_Central )
(Gaudet et al., 2011)
compound eye morphogenesis
non-traceable author statement
(Baker, 2001)
dendrite morphogenesis
non-traceable author statement
(Grueber and Jan, 2004)
dorsal closure
traceable author statement
(Harden, 2002, Noselli and Agnes, 1999)
negative regulation of salivary gland boundary specification
traceable author statement
(Bradley et al., 2001)
protein phosphorylation
inferred from biological aspect of ancestor with PANTHER:PTN002758232
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
activin receptor complex
inferred from physical interaction with FLYBASE:babo; FB:FBgn0011300
(Lee-Hoeflich et al., 2005, Brummel et al., 1999, Das et al., 1999, Wrana et al., 1994)
BMP receptor complex
inferred from physical interaction with FLYBASE:sax; FB:FBgn0003317
(Letsou et al., 1995)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
activin receptor complex
inferred from biological aspect of ancestor with PANTHER:PTN001147373
(assigned by GO_Central )
(Gaudet et al., 2011)
plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN002758232
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence model
(Childs et al., 1993)
receptor complex
inferred from biological aspect of ancestor with PANTHER:PTN000583675
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism | intense | ubiquitous

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
pole cell
(Fisher et al., 2012)
embryonic stage 7 -- 8
anterior endoderm anlage
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
pole cell
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
embryonic stage 9 -- 10
anterior endoderm
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
visceral muscle primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic/larval midgut
(Fisher et al., 2012)
embryonic/larval visceral muscle
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 6 -- 11
mesoderm
(Childs et al., 1993)
adult stage & oogenesis
oocyte
(Childs et al., 1993)
nurse cell
(Childs et al., 1993)
embryonic stage 11 -- 16
embryonic/larval midgut
(Childs et al., 1993)
embryonic/larval hindgut
(Childs et al., 1993)
embryonic/larval foregut
(Childs et al., 1993)
embryonic stage 1 -- 4
organism | ubiquitous
(Childs et al., 1993)
embryonic stage 5
pole cell
(Childs et al., 1993)
third instar larval stage
imaginal disc
(Childs et al., 1993)
embryonic stage -- adult stage
(Childs et al., 1993)
Additional Descriptive Data
put transcripts are detected throughout development on northern blots. They are abundant in nurse cells and in the developing oocyte. The transcript persists at high levels in the embryo until cellularization. Transcript levels decrease at cellularization but remain highest under the pole cells. At the start of gastrulation, transcripts are observed in the invaginating mesoderm. By stage 11, expression is observed along the entire length of the germ band in the mesoderm as well as in the developing gut. Expression continues in the fore- mid- and hindgut throughout most of embryogenesis. Third instar larval imaginal discs show prominant put expression.
(Childs et al., 1993)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 11 -- 16
embryonic/larval foregut
(Childs et al., 1993)
embryonic/larval hindgut
(Childs et al., 1993)
embryonic stage 6 -- 11
mesoderm
(Childs et al., 1993)
embryonic stage 5
pole cell
(Childs et al., 1993)
embryonic stage 14 -- 16
embryonic/larval anterior midgut
(Childs et al., 1993)
embryonic stage 11 -- 13
embryonic/larval midgut
(Childs et al., 1993)
embryonic stage 4
organism | ubiquitous
(Childs et al., 1993)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
put protein is observed throughout the embryo at syncytial blastoderm stage. At the start of gastrulation, Pburs protein is observed in the invaginating mesoderm. By stage 11 it is expressed along the entire length of the germ band in the mesoderm as well as in the developing gut. Expression continues in the fore- mid- and hindgut throughout most of embryogenesis.
(Childs et al., 1993)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
activin receptor complex
inferred from physical interaction with FLYBASE:babo; FB:FBgn0011300
(Lee-Hoeflich et al., 2005, Brummel et al., 1999, Das et al., 1999, Wrana et al., 1994)
BMP receptor complex
inferred from physical interaction with FLYBASE:sax; FB:FBgn0003317
(Letsou et al., 1995)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\put in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 20 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 23 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of put
Transgenic constructs containing regulatory region of put
Deletions and Duplications ( 7 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal, with Scer\GAL4Act5C.PU
lethal, with Scer\GAL4GMR.PF, Scer\GAL4ey.PH
lethal, with Scer\GAL4pnr-MD237
lethal (with put135)
lethal (with putD13)
lethal (with putD18)
lethal | embryonic stage | recessive
lethal | maternal effect | recessive
lethal | pupal stage, with Scer\GAL4pnr-MD237
lethal | recessive
lethal - all die before end of embryonic stage | recessive
lethal - all die before end of embryonic stage | recessive | heat sensitive
lethal - all die during P-stage, with Scer\GAL4Mef2.PR
partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237
partially lethal - majority die | recessive | cold sensitive
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
female sterile, with Scer\GAL4VP16.mat.αTub67C
Other Phenotypes
Allele
decreased cell number | spermatogenesis | heat sensitive (with put135)
decreased cell number | spermatogenesis | heat sensitive (with put10460)
decreased cell size | somatic clone | spermatogenesis
decreased occurrence of cell division | oogenesis | oogenesis
decreased occurrence of cell division | somatic clone | third instar larval stage
hyperplasia | somatic clone
increased cell number | somatic clone | spermatogenesis
increased occurrence of cell division | somatic clone | spermatogenesis
locomotor behavior defective | adult stage, with Scer\GAL4Mef2.PR
neuroanatomy defective | embryonic stage, with Scer\GAL4RapGAP1-OK6
neuroanatomy defective | embryonic stage | heat sensitive
neuroanatomy defective | embryonic stage | heat sensitive (with put62)
neuroanatomy defective | embryonic stage | heat sensitive (with put135)
neuroanatomy defective | larval stage
neuroanatomy defective | somatic clone
neuroanatomy defective | third instar larval stage, with Scer\GAL4C57
size defective | adult stage, with Scer\GAL4A9
size defective | adult stage, with Scer\GAL4dsx.KI
size defective | adult stage, with Scer\GAL4esg.PU
size defective | spermatogenesis | heat sensitive (with put135)
size defective | spermatogenesis | heat sensitive (with put10460)
small body (with put51)
small body (with put135)
some die during embryonic stage | recessive
some die during embryonic stage | recessive | heat sensitive
some die during embryonic stage | rescuable maternal effect
visible
visible, with Scer\GAL4A9
visible, with Scer\GAL4hs.PB
visible, with Scer\GAL4pnr-MD237
visible, with Scer\GAL4ptc-559.1
visible, with Scer\GAL4tsh-Gal4-1
visible, with Scer\GAL4vg.PM
visible | adult stage, with Scer\GAL4A9
visible | recessive
wild-type
Phenotype manifest in
Allele
abdominal segmental nerve | heat sensitive
abdominal segmental nerve | heat sensitive (with put62)
abdominal segmental nerve | heat sensitive (with put135)
adult optic lobe | somatic clone
antenna
antenna | distal
antenna | distal | heat sensitive
antenna | heat sensitive
antenna | pharate adult stage
anterior crossvein, with Scer\GAL4ptc-559.1
bouton | third instar larval stage, with Scer\GAL4C57
crystal cell
dense core granule | adult stage, with Scer\GAL4NP0261
dorsal branch primordium
dorsal cluster neuron & axon | somatic clone
dorsal cluster neuron & neurite | somatic clone
dorsal cluster neuron & neurite | somatic clone | conditional ts
dorsal cluster neuron | somatic clone
dorsal cluster neuron | somatic clone | heat sensitive
dorsal mesothorax
dorsal mesothorax | heat sensitive
dorsocentral bristle
embryo | anterior | dorsal
embryo | dorsal closure stage | heat sensitive (with put62)
embryo | dorsal closure stage | heat sensitive (with put135)
embryo | maternal effect, with Scer\GAL4VP16.mat.αTub67C
embryonic/first instar larval cuticle
embryonic/first instar larval cuticle | dorsal
embryonic/first instar larval cuticle | dorsal | germline clone
embryonic/first instar larval cuticle | dorsal | heat sensitive
embryonic/first instar larval cuticle | heat sensitive
embryonic/larval dorsal branch
embryonic/larval dorsal trunk
embryonic/larval lateral trunk
embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4C57
embryonic/larval tracheal system
embryonic abdominal segment 1 | heat sensitive
embryonic abdominal segment 2 | heat sensitive
embryonic abdominal segment 3 | heat sensitive
embryonic abdominal segment 4 | heat sensitive
embryonic abdominal segment 5 | heat sensitive
embryonic abdominal segment 6 | heat sensitive
embryonic abdominal segment 7 | heat sensitive
embryonic abdominal segment 8 | heat sensitive
embryonic abdominal segment 9 | heat sensitive
embryonic abdominal segment 10 | heat sensitive
embryonic abdominal segment 11 | heat sensitive
embryonic dorsal epidermis
embryonic epidermis
embryonic epidermis | heat sensitive
embryonic head
embryonic head | heat sensitive
eye
eye | heat sensitive
eye | pharate adult stage
eye disc | posterior | somatic clone
eye disc | somatic clone
eye disc posterior compartment | somatic clone | third instar larval stage
fascicle | somatic clone
female germline stem cell
female germline stem cell (with put135)
female germline stem cell (with put10460)
ganglion mother cell | larval stage
germline cell
interommatidial bristle
interommatidial bristle | heat sensitive
intersegmental nerve, with Scer\GAL4RapGAP1-OK6
intersegmental nerve | heat sensitive
intersegmental nerve | heat sensitive (with put62)
intersegmental nerve | heat sensitive (with put135)
intestinal stem cell | somatic clone
larval neuroblast | larval stage
leg
leg | distal
leg | distal | heat sensitive
leg | dorsal | pharate adult stage
leg | heat sensitive
leg | pharate adult stage | ventral
lysosome | adult stage, with Scer\GAL4dsx.KI
macrochaeta
macrochaeta | ectopic, with Scer\GAL4hs.PB
macrochaeta | ectopic, with Scer\GAL4tsh-Gal4-1
male accessory gland secondary cell, with Scer\GAL4dsx.KI
male accessory gland secondary cell, with Scer\GAL4esg.PU
male accessory gland secondary cell, with Scer\GAL4NP0261
male germline cyst | somatic clone | spermatogenesis
male germline stem cell | germline clone
male germline stem cell | heat sensitive (with put135)
male germline stem cell | heat sensitive (with put10460)
Malpighian tubule
mesothoracic tergum, with Scer\GAL4pnr-MD237
morphogenetic furrow
multivesicular body | adult stage, with Scer\GAL4dsx.KI
nucleus | adult stage, with Scer\GAL4esg.PU
ommatidium
ommatidium | heat sensitive
photoreceptor cell | somatic clone
pigment granule
plasmatocyte
primary pigment cell | pupal stage P7
protocerebrum | somatic clone
salivary gland
scutum & macrochaeta, with Scer\GAL4hs.PB
scutum & macrochaeta, with Scer\GAL4tsh-Gal4-1
secretory vesicle | adult stage, with Scer\GAL4dsx.KI
sensory mother cell & dorsal mesothoracic disc
sex comb
sex comb | heat sensitive
somatic muscle (with put51)
somatic muscle (with put135)
spermatogonium | heat sensitive (with put135)
spermatogonium | heat sensitive (with put10460)
tertiary pigment cell | pupal stage P7
testis | germline clone
testis | heat sensitive (with put135)
testis | heat sensitive (with put10460)
wing
wing, with Scer\GAL4A9
wing, with Scer\GAL4Bx-MS1096
wing, with Scer\GAL4vg.PM
wing blade posterior compartment, with Scer\GAL4vg.int2.1
wing cell
wing margin | ectopic
wing vein
wing vein, with Scer\GAL4A9
wing vein | ectopic
wing vein L2, with Scer\GAL4A9
wing vein L3, with Scer\GAL4A9
wing vein L4, with Scer\GAL4A9
wing vein L5, with Scer\GAL4A9
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (5)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\ACVR2B
13 of 15
Yes
Yes
Hsap\ACVR2A
12 of 15
No
Yes
Hsap\TGFBR2
3 of 15
No
Yes
Hsap\AMHR2
2 of 15
No
No
Hsap\BMPR2
2 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (5)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Acvr2a
13 of 15
Yes
Yes
Mmus\Acvr2b
13 of 15
Yes
Yes
Mmus\Tgfbr2
3 of 15
No
Yes
Mmus\Bmpr2
2 of 15
No
No
Mmus\Amhr2
1 of 15
No
No
Rattus norvegicus (Norway rat) (5)
Rnor\Acvr2a
11 of 13
Yes
Yes
Rnor\Acvr2b
8 of 13
No
Yes
Rnor\Amhr2
2 of 13
No
No
Rnor\Bmpr2
2 of 13
No
No
Rnor\Tgfbr2
2 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (4)
Xtro\acvr2a
6 of 12
Yes
Yes
Xtro\acvr2b
6 of 12
Yes
Yes
Xtro\bmpr2
1 of 12
No
No
Xtro\tgfbr2
1 of 12
No
Yes
Danio rerio (Zebrafish) (9)
Drer\acvr2aa
13 of 15
Yes
Yes
Drer\LOC100331938
9 of 15
No
Yes
Drer\acvr2ba
8 of 15
No
Yes
Drer\acvr2ab
5 of 15
No
Yes
Drer\tgfbr2b
3 of 15
No
Yes
Drer\si:dkey-101k6.5
2 of 15
No
Yes
Drer\tgfbr2b
2 of 15
No
Yes
Drer\bmpr2a
1 of 15
No
No
Drer\bmpr2b
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\daf-4
8 of 15
Yes
Yes
Cele\daf-1
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (6)
Atha\AT2G19210
1 of 9
Yes
Yes
Atha\AT3G45410
1 of 9
Yes
Yes
Atha\AT3G53380
1 of 9
Yes
Yes
Atha\AT4G23050
1 of 9
Yes
Yes
Atha\CRK42
1 of 9
Yes
Yes
Atha\XIP1
1 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091905MD )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\put
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00012246
Drosophila simulans
Dsim\GD20410
Drosophila sechellia
Dsec\GM25839
Drosophila erecta
Dere\GG21187
Drosophila yakuba
Dyak\GE26437
Drosophila ananassae
Dana\GF17542
Drosophila pseudoobscura pseudoobscura
Dpse\GA20674
Drosophila persimilis
Dper\GL23126
Drosophila willistoni
Dwil\GK14450
Drosophila virilis
Dvir\GJ23013
Drosophila mojavensis
Dmoj\GI10656
Drosophila grimshawi
Dgri\GH14126
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915057F )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17016681
Glossina morsitans
Tsetse fly
Gmor\GMOY005812
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_05213
Mayetiola destructor
Hessian fly
Mdes\Mdes001658
Mayetiola destructor
Hessian fly
Mdes\Mdes014288
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL009652
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL007384
Anopheles darlingi
American malaria mosquito
Adar\ADAC001802
Anopheles gambiae
Malaria mosquito
Agam\AGAP000763
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ017753
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W02O1 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA013608
Danaus plexippus
Monarch butterfly
Dple\DPOGS204127-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL012902
Apis florea
Little honeybee
Aflo\3517994292
Apis mellifera
Western honey bee
Amel\put
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP13836
Bombus terrestris
Buff-tailed bumblebee
Bter\15216077
Linepithema humile
Argentine ant
Lhum\LH18061
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002f4b
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG009567
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG010886
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_02368
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_02369
Tribolium castaneum
Red flour beetle
Tcas\put
Pediculus humanus
Human body louse
Phum\PHUM105440
Rhodnius prolixus
Kissing bug
Rpro\put
Cimex lectularius
Bed bug
Clec\CLEC001795
Cimex lectularius
Bed bug
Clec\CLEC001794
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI004428
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_00777
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X01U2 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR009121
Strigamia maritima
European centipede
Smar\SMAR000389
Ixodes scapularis
Black-legged tick
Isca\ISCW020983
Ixodes scapularis
Black-legged tick
Isca\ISCW001127
Stegodyphus mimosarum
African social velvet spider
Smim\KFM65634.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM68339.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM61867.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur02g05430
Tetranychus urticae
Two-spotted spider mite
Turt\tetur08g06290
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G03YO )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Bmpr2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-TgfbrtII
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Acvr2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Bmpr2_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Acvr2_1
Ciona intestinalis
Vase tunicate
Cint\tgfbr-iib
Ciona intestinalis
Vase tunicate
Cint\tgfbr-iia
Gallus gallus
Domestic chicken
Ggal\LOC424261
Gallus gallus
Domestic chicken
Ggal\ACVR2A
Gallus gallus
Domestic chicken
Ggal\TGFBR2
Gallus gallus
Domestic chicken
Ggal\ACVR2B
Gallus gallus
Domestic chicken
Ggal\BRK-3
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (4)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
wit
5 of 10
babo
2 of 10
sax
2 of 10
tkv
2 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Allele
Disease
Evidence
References
put135
model of  juvenile polyposis syndrome
CEA
(Guo et al., 2013)
Potential Models Based on Orthology ( 4 )
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
ACVR2B; activin A receptor type 2B
13 of 15
602730
ACVR2A; activin A receptor type 2A
12 of 15
102581
      TGFBR2; transforming growth factor beta receptor 2
      3 of 15
      190182
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      Summary of Genetic Interactions
      esyN Network Diagram
      esyN Network Key:
      Suppression
      Enhancement
      View in Interactions Browser
      Please look at the allele data for full details of the genetic interactions
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      put
      enhanceable
      I-2
      (Bennett et al., 2003)
      put
      enhanceable
      NiPp1
      (Bennett et al., 2003)
      put
      enhanceable
      Pp1-87B
      (Bennett et al., 2003, Bennett and Alphey, 2002)
      NiPp1|put
      suppressible
      Pp1-87B
      (Bennett et al., 2003)
      I-2|put
      suppressible
      Pp1-87B
      (Bennett et al., 2003)
      put
      suppressible
      Raf
      (Yan et al., 2009)
      I-2|put
      suppressible
      tkv
      (Bennett et al., 2003)
      put
      enhanceable
      tkv
      (Bennett et al., 2003)
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      anchor
      suppressible
      put
      (Wang et al., 2018)
      CycE
      suppressible
      dpp|put
      (Horsfield et al., 1998)
      dally
      enhanceable
      put
      (Fujise et al., 2001)
      daw
      enhanceable
      put
      (Parker et al., 2006)
      Dd
      suppressible
      put
      (Liu et al., 2011)
      ea
      enhanceable
      put
      (George and Terracol, 1997)
      gbb
      suppressible
      put
      (Bangi and Wharton, 2006)
      Mad
      enhanceable
      put
      (Haerry, 2010)
      Myc
      suppressible
      put
      (Moreno and Basler, 2004)
      Raf
      suppressible
      put
      (Yan et al., 2009)
      tkv
      enhanceable
      put
      (Chen et al., 1998)
      upd1
      suppressible
      put
      (Bach et al., 2003)
      External Data
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      MIST (genetic) - An integrated Molecular Interaction Database
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Pathways
      Signaling Pathways (FlyBase)
      BMP Signaling Pathway Core Components -
      The Bone Morphogenetic Protein (BMP) signaling pathway is one of two branches of Transforming Growth Factor-β family signaling in Drosophila. The binding of a BMP family dimer to a heterodimeric serine/threonine kinase receptor complex results in the phosphorylation of Mad, a member of the Smad family. Mad forms a complex with the co-Smad, Med. This complex translocates into the nucleus and regulates the transcription of target genes in concert with other nuclear cofactors. (Adapted from FBrf0236482.)
      Activin Signaling Pathway Core Components -
      The activin signaling pathway is one of two branches of Transforming Growth Factor-β family signaling in Drosophila. The binding of an activin family dimer to a heterodimeric serine/threonine kinase receptor complex results in the phosphorylation of Smox, a members of the Smad family. Smox forms a complex with the co-Smad, Med. This complex translocates into the nucleus and regulates the transcription of target genes in concert with other nuclear cofactors. (Adapted from FBrf0236482.)
      Metabolic Pathways
      External Data
      Linkouts
      KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      3R
      Recombination map
      3-55
      Cytogenetic map
      88C9-88C9
      Sequence location
      3R:14,619,030..14,625,703 [-]
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      88C9-88C9
      Limits computationally determined from genome sequence between P{PZ}cv-c06951 and P{PZ}put10460
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      88C9-88C10
      (determined by in situ hybridisation)
      (Ranz et al., 2001, Spradling et al., 1999, Perrimon et al., 1996)
      88C6-88C7
      88C9--10
      (BDGP Project Members, 1994-1999)
      88D-88D
      (determined by in situ hybridisation)
      (Childs et al., 1993)
      Experimentally Determined Recombination Data
      Location
      3-55
      (FlyBase, 2016)
      3-54.2
      (Comeron et al., 2012)
      3-58
      (Tearle and Nusslein-Volhard, 1987)
      Left of (cM)
      Right of (cM)
      (Jurgens et al., 1984)
      Notes
      Stocks and Reagents
      Stocks (15)
      Genomic Clones (26)
      cDNA Clones (64)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequences
      BDGP DGC clones
      Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         
        polyclonal
        (Childs et al., 1993)
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of
        Source for identity of: put CG7904
        (Zheng, 1999.11)
        Source for database merge of
        Additional comments
        Other Comments
        The put product negatively regulates dac expression in the embryonic head.
        (Anderson et al., 2006)
        put is required during the late larval stage for development of adult-specific neurons.
        (Zheng et al., 2006)
        dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
        (Kiger et al., 2003)
        One of five genes identified as encoding downstream components of the dpp signalling cascade which is necessary for blocking salivary gland gene activation by Scr in the dorsal region of parasegment 2.
        (Henderson et al., 1999)
        Loss of function alleles of tkv, put, Mad, Med and shn suppress the CycEJP mutant eye phenotype in combination with dppd-ho.
        (Horsfield et al., 1998)
        The embryonic dorsoventral patterning and dorsal closure phenotypes seen in put mutants correspond to distinct maternal and zygotic requirements for put.
        (Simin et al., 1998)
        shn and put are required to limit transient amplification of germ cells. Mosaic analysis demonstrates shn and put act within somatic cyst cells that surround germ cells, rather than in germ cells. Thus a cyst-cell-derived signal restricts germ cell proliferation and this signal is initiated by input from a member of the TGF-β superfamily. Thus, a signal relay regulates progression through the germline stem cell lineage.
        (Matunis et al., 1997)
        dpp receptors tkv and put are not required for photoreceptor cell differentiation. tkv and put play a nonessential role in morphogenetic furrow progression, but are required for initiation of the furrow at the posterior margin. Ectopic activation of the dpp pathway does not lead to ectopic neuronal differentiation.
        (Burke and Basler, 1996)
        dpp receptors put and tkv, or the shn transcription factor, are autonomously required for cell proliferation in the entire developing wing. The dpp signal has to travel several cell diameters from its source in order to reach all cells that require its signal.
        (Burke and Basler, 1996)
        put gene product is a dpp type II receptor, type II receptors have a dual ligand binding specificity.
        (Arora et al., 1995)
        Genetic interactions and the strikingly similar phenotypes in shn and dpp receptors encoded by thv and put suggest the shn plays a downstream role in dpp signalling.
        (Arora et al., 1995)
        Activin type II receptor is encoded by the put gene. Loss of the maternal function of the put gene disrupts a signalling pathway required for embryonic pattern function, causing cells throughout the embryo to adopt a fate normally reserved for those at the ventral surface.
        (Letsou et al., 1995)
        Maternal and zygotic loss of put ventralises the embryo.
        (Letsou et al., 1995)
        Mitotic recombination analysis demonstrates a requirement for maternal put gene product in dorsal-ventral patterning.
        (Letsou et al., 1995)
        The P-element line 10460 fails to complement the EMS allele put135.
        (Ruberte et al., 1995)
        put and tkv encode type II and type I receptors, both act in concert to mediate all known dpp signalling processes in the developing midgut.
        (Ruberte et al., 1995)
        put encodes a type II receptor for dpp, Rec88D.
        (Xie et al., 1995)
        Ligand binding studies reveal put gene product binds activin with high specificity. The sequence and binding characteristics of put indicate that only a small number of amino acids are required for specification of activin binding.
        (Childs et al., 1993)
        TGF-β like activity is present in cell extracts.
        (Benzakour et al., 1990)
        put mutants display failure of dorsal closure.
        (Jurgens et al., 1984)
        Origin and Etymology
        Discoverer
        Etymology
        Identification
        External Crossreferences and Linkouts ( 54 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        modMine - A data warehouse for the modENCODE project
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        SignaLink - A signaling pathway resource with multi-layered regulatory networks.
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        FlyMine - An integrated database for Drosophila genomics
        Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Synonyms and Secondary IDs (26)
        Reported As
        Symbol Synonym
        Act-r
        Atr
        Atr-II
        (Josso and di Clemente, 1997, Moses and Serra, 1996, Ruberte et al., 1995, Wharton, 1995, Hogan, 1994, Wrana et al., 1994, Childs et al., 1993)
        Atr88CD
        AtrII
        CG7904
        (Hosono et al., 2015, Cui et al., 2013, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Mummery-Widmer et al., 2009, Perkins et al., 2009, Schiess et al., 2009, Toledano-Katchalski et al., 2007, Kim et al., 2004, Morrison et al., 2000)
        PUNT
        (Hill, 1996)
        Punt
        (Ahmed-de-Prado and Baonza, 2018, Liu and Jin, 2017, Richard et al., 2017, Upadhyay et al., 2017, Bausek, 2013, Mbodj et al., 2013, Yamanaka et al., 2013, Lim et al., 2012, Zoller and Schulz, 2012, Eliazer and Buszczak, 2011, Schwank et al., 2011, Kamiya et al., 2008, Yao et al., 2008, Huggins et al., 2002)
        Put
        (Follansbee et al., 2017, Song et al., 2017, Wells et al., 2017, Jiang et al., 2016, Bier and De Robertis, 2015, Bausek, 2013, Haerry, 2010, Yakoby et al., 2007, Dudu, 2006)
        STK-C
        (Ruberte et al., 1995)
        TGF-B
        (Gibson and Schubiger, 2001)
        TGF-β
        (Bonfini et al., 2016, Benzakour et al., 1990)
        Tgf-r
        atrII
        (Vanden Broeck et al., 2001)
        dlhC
        l(3)10460
        (Perrimon et al., 1996)
        l(3)j5A5
        pun
        (Martinez Arias, 1993)
        punt
        (Whittle and Extavour, 2019, Eusebio et al., 2018, Al Khatib et al., 2017, Gleason et al., 2017, Makhijani et al., 2017, Redhai et al., 2016, Sopko et al., 2014, Yan et al., 2014, Boulanger et al., 2012, Pennetier et al., 2012, Schwank et al., 2011, Li et al., 2010, Jin et al., 2008, Kirilly et al., 2005)
        put
        (Bangi et al., 2019, Ng, 2019.8.30, Xu et al., 2019, Ameku et al., 2018, Hoyer et al., 2018, Le et al., 2018, Wang et al., 2018, Yeung et al., 2018, Houtz et al., 2017, Jordán-Álvarez et al., 2017, Ma et al., 2017, Song et al., 2017, Moulton and Letsou, 2016, Sarov et al., 2016, Aradska et al., 2015, Ugrankar et al., 2015, Ashwal-Fluss et al., 2014, Roy et al., 2014, Sopko et al., 2014, Sulkowski et al., 2014, Curtis et al., 2013, Li et al., 2013, Marinho et al., 2013, Saunders et al., 2013, Le and Wharton, 2012, Jungreis, 2011.11.18, Michel et al., 2011, Neumüller et al., 2011, Yuva-Aydemir et al., 2011, Ables and Drummond-Barbosa, 2010, Salzer et al., 2010, Cook et al., 2009.11.25, Wagner et al., 2009, Yan et al., 2009, Ng, 2008, Wang et al., 2008, Adryan et al., 2007, Chen et al., 2007, Cordero et al., 2007, Dietzl et al., 2007, Fernández et al., 2007, Zeitlinger et al., 2007, Anderson et al., 2006, Bangi and Wharton, 2006, Joulia et al., 2006, Li and Li, 2006, Roote, 2006.8.30, Xie et al., 2005, Bennett and Alphey, 2002, Pickeral et al., 2000, Riesgo-Escovar and Hafen, 1997)
        Name Synonyms
        Activin-A-receptor-88CD
        DPP receptor
        (Gonzalez-Reyes, 2003)
        PUNT
        (Gesualdi and Haerry, 2007)
        Punt
        (Gui et al., 2016, Niwa and Niwa, 2016, Roy et al., 2014, Fuentes-Medel et al., 2012, Raftery and Umulis, 2012, Chen and Xu, 2010, Arora et al., 2008, Xu et al., 2007, Chen et al., 2006, Parker et al., 2006)
        TGF-β-type-receptor-like
        activin receptor
        (Childs, 1993.12.9)
        activin receptor type II
        (Childs et al., 1993)
        dorsal holes C
        punt
        (Whittle and Extavour, 2019, Chandran et al., 2018, Kang et al., 2018, Tseng et al., 2018, Song et al., 2017, Wieschaus and Nüsslein-Volhard, 2016, Iordanou et al., 2014, Cui et al., 2013, Denholm, 2013, Guo et al., 2013, Laver et al., 2013, Marinho et al., 2013, Peterson et al., 2012, Liu et al., 2011, Salzer et al., 2010, Jensen et al., 2009, Wagner et al., 2009, Yu et al., 2009, Wang et al., 2008, Fernández et al., 2007, Toledano-Katchalski et al., 2007, Anderson et al., 2006, Chen and Schupbach, 2006, Serpe and O'Connor, 2006, Bennett and Alphey, 2002, Lee and Treisman, 2001, Brummel et al., 1999, Byars et al., 1999, Chen et al., 1998, Hazelett et al., 1998, Horsfield et al., 1998, Simin et al., 1998, Tomoyasu et al., 1998, Xie and Spradling, 1998, Riesgo-Escovar and Hafen, 1997, Akhmanova, 1996.4.22, Burke and Basler, 1996, Arora et al., 1995, Basler, 1995.4.24, Letsou et al., 1995)
        Secondary FlyBase IDs
        • FBgn0000467
        • FBgn0004912
        • FBgn0004920
        • FBgn0010942
        • FBgn0011375
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        References (370)