Atr-II, TGF-β, l(3)10460
receptor for Dpp - type II TGFß receptor - functions in both Dpp/BMP and Activin signaling - mutants lack and expression in the visceral mesoderm and fail to induce in the adjacent endodermal cells - pathway specificity in signaling output is determined by which type I receptor (Dpp/BMP or Activin one) is engaged in the complex with Put
Please see the JBrowse view of Dmel\put for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.44
Stop-codon suppression (UAG) postulated; FBrf0216885.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.46
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
2.7 (unknown)
2.7 (northern blot)
516 (aa)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\put using the Feature Mapper tool.
put transcripts are detected throughout development on northern blots. They are abundant in nurse cells and in the developing oocyte. The transcript persists at high levels in the embryo until cellularization. Transcript levels decrease at cellularization but remain highest under the pole cells. At the start of gastrulation, transcripts are observed in the invaginating mesoderm. By stage 11, expression is observed along the entire length of the germ band in the mesoderm as well as in the developing gut. Expression continues in the fore- mid- and hindgut throughout most of embryogenesis. Third instar larval imaginal discs show prominant put expression.
put protein is observed throughout the embryo at syncytial blastoderm stage. At the start of gastrulation, Pburs protein is observed in the invaginating mesoderm. By stage 11 it is expressed along the entire length of the germ band in the mesoderm as well as in the developing gut. Expression continues in the fore- mid- and hindgut throughout most of embryogenesis.
GBrowse - Visual display of RNA-Seq signals
View Dmel\put in GBrowse 2Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: put CG7904
put is required during the late larval stage for development of adult-specific neurons.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
shn and put are required to limit transient amplification of germ cells. Mosaic analysis demonstrates shn and put act within somatic cyst cells that surround germ cells, rather than in germ cells. Thus a cyst-cell-derived signal restricts germ cell proliferation and this signal is initiated by input from a member of the TGF-β superfamily. Thus, a signal relay regulates progression through the germline stem cell lineage.
dpp receptors tkv and put are not required for photoreceptor cell differentiation. tkv and put play a nonessential role in morphogenetic furrow progression, but are required for initiation of the furrow at the posterior margin. Ectopic activation of the dpp pathway does not lead to ectopic neuronal differentiation.
Maternal and zygotic loss of put ventralises the embryo.
Mitotic recombination analysis demonstrates a requirement for maternal put gene product in dorsal-ventral patterning.
TGF-β like activity is present in cell extracts.
put mutants display failure of dorsal closure.
