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Gene Dmel\px

General Information
Symbol	Dmel\px	Species	D. melanogaster
Name	plexus	Annotation symbol	CG4444
Feature type	protein_coding_gene	FlyBase ID	FBgn0003175
Gene Model Status	Current	Stock availability	90 publicly available
Also Known As	l(2)k08316
Genomic Location
Chromosome (arm)	2R	Recombination map	2-100.5
Cytogenetic map	58E4-58E8	Sequence location	2R:18,381,802..18,449,570 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene plexus is referred to in FlyBase by the symbol Dmel\px (CG4444, FBgn0003175). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: inter-male aggressive behavior; imaginal disc-derived wing vein morphogenesis. 58 alleles are reported. The phenotypes of these alleles are annotated with: leg; eye; wing; wing vein. It has 4 annotated transcripts and 4 annotated polypeptides. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult crop, adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, larval/adult fat body, adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1638412_at completely aligns to an exonic region of only a subset of 2 of the 3 FlyBase-annotated transcript isoforms of px. Gene sequence location is 2R:18381802..18449570.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	px: plexus px: plexus From "Edith M. Wallace, unpublished." Wings have network of extra veins, especially towards tips and margins; L4 vein bent near tip. Semidominant with some Minutes. Suppressed by S (Bedichek, 1936, DIS 4: 24); suppresses expression of ve (Thompson, 1973, DIS 50: 59). Venation effect caused by inadequate contraction of wing during pupal stage, leaving spaces between epithelial layers (Waddington, 1940). Vein patterns of px flies studied in lines selected for increased or decreased expression (Thompson, 1974).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 58E4-58E8   Limits computationally determined from genome sequence between P{lacW}l(2)k13211k13211&P{EP}EP827 and P{PZ}l(2)rG270rG270
Experimentally Determined Cytological Location
Cytogenetic map Notes References 58E1-58E2   (determined by in situ hybridisation)   (Spradling et al., 1999) 58E1-58E2   59B1--2   (BDGP Project Members, 1994-1999) 58E1-58E2   The cytological location of either the P{lacW}pxk08316 insert (58E1-58E2) or the P{lacW}pxk08134 insert (59B1-59B2) must be wrong, but this has not been resolved. (determined by in situ hybridisation) 59B1--2 (determined by in situ hybridisation)   (Spradling, 1999.12.9)
Experimentally Determined Recombination Data
Location	2-100.5 (Williams, 1956)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\px for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.45 Gene model reviewed during 5.48
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) px-RA FBtr0071838  NM_166535   6842   1995 px-RB FBtr0112820  NM_001103947   5214   1535 px-RD FBtr0331941  NM_001274206   4365   944 px-RE FBtr0331942  NM_001274207   8360   1916
Additional Transcript Data & Comments
Reported size (kB)	7.3, 5.8, 5.3 (northern blot) (Matakatsu et al., 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein px-PA   FBpp0071749   213.9   1995   8.77     NP_726208   AAF46855 px-PB   FBpp0111732   164.1   1535   8.94     NP_001097417   ABV53884 px-PD   FBpp0304274   98.7   944   9.10     NP_001261135   AGB93666 px-PE   FBpp0304275   206.0   1916   8.80     NP_001261136   AGB93667
Additional Polypeptide Data & Comments
Reported size (kDa)	1990 (aa); 213 (kD predicted) (Matakatsu et al., 1999)
Comments
External Data
Linkouts
Crossreferences
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA390944   AA699237   AE013599 AAF46855   AB032181 BAA86717   AE013599 ABV53884   AE013599 AGB93666   AE013599 AGB93667   AI530850   AI542354   AQ025858   AQ034014   AW944190   AY058753 AAL13982   AY089343   BG637998   BI367551   BI367593   BI575864   BI584433   BI632150   BI632835   BI633245   BI636560   BI636624   BT029592   BT132822   CK445224   CL527722   CL528203   CL844327   CO153137   CO153855   CO190198   CO264753   CO270436   CO274099   CO278895   CO286158   CO296771   CO296848   CO299982   CO302855   CO303553   CO303863   CO311059   CO314969   CO315485   CO315769   CO317004   CO325929   CO326641   CO329021   CO331803   CO337451   CO339269   CO342155   CO344291   CO344394   CZ467475   CZ469640   CZ469704   CZ469705   CZ470157   CZ470650   CZ470651   CZ470670   CZ471622   CZ472532   CZ472533   CZ474591   CZ480715   CZ482884   CZ482885   CZ484654   CZ485850   CZ487328   CZ489242   EC052497   EC053488   EC053626   EC053740   EC054343   EC055476   EC056589   EC060885   EC060986   EC064949   EC074475   EC077126   EC077865   EC083484   EC084169   EC088507   EC195512   EC195955   EC199249   EC201776   EC205206   EC208405   EC211305   EC213512   EC234256   EC238385   EC241395   EC247877   EC254790   EC255568   EC256710   EC257465   EC264296   EL885465   EL885696   EL885817   EL885818   EV587918
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9W244 A8DYM3 A8DYM2 Q95TI5 Q9U8Q0
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage & larval stage     (Matakatsu et al., 1999)
Additional Descriptive Data
	5.3kb px transcripts are detected in embryos and larvae on northern blots. (Matakatsu et al., 1999) 7.3kb px transcripts are detected in embryos and larvae on northern blots. (Matakatsu et al., 1999) 5.8kb px transcripts are detected in embryos and larvae on northern blots. (Matakatsu et al., 1999)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 8   cell   • nucleus & nuclear matrix (Matakatsu et al., 1999) third instar larval stage   wing disc   (Matakatsu et al., 1999) wing pouch   • nucleus & nuclear matrix (Matakatsu et al., 1999) salivary gland   • nucleus & nuclear matrix (Matakatsu et al., 1999)
Additional Descriptive Data
	px protein is ubiquitously distributed in the nucleus. (Matakatsu et al., 1999)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
nuclear matrix inferred from direct assay (Matakatsu et al., 1999)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult crop, adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, larval/adult fat body, adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    101.9 Larval Midgut    91.4 Larval Hindgut    176.5 Larval Malpighian Tubules    299.6 Larval Fat Body    199.9 Larval Salivary Gland    667.2 Larval Trachea    162.725 Larval Carcass    106.8 Adult Head    93.6 Adult Eye    49.4 Adult Brain    54.5 Adult Thoracic-Abdominal Ganglion    57.3 Adult Crop    180.5 Adult Midgut    198.7 Adult Hindgut    239.2 Adult Malpighian Tubules    119.2 Adult Fat Body    124.4 Adult Salivary Gland    179.8 Adult Heart    86.275 Adult VirginFemale Spermatheca    140.8 Adult InseminatedFemale Spermatheca    104.3 Adult Ovary    157.3 Adult Testis    29.9 Adult Male Accessory Gland    131.7 Adult Carcass    116.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    101.9 Larval Midgut    91.4 Larval Hindgut    176.5 Larval Malpighian Tubules    299.6 Larval Fat Body    199.9 Larval Salivary Gland  (667.2) Larval Trachea    162.725 Larval Carcass    106.8 Adult Head    93.6 Adult Eye    49.4 Adult Brain    54.5 Adult Thoracic-Abdominal Ganglion    57.3 Adult Crop    180.5 Adult Midgut    198.7 Adult Hindgut    239.2 Adult Malpighian Tubules    119.2 Adult Fat Body    124.4 Adult Salivary Gland    179.8 Adult Heart    86.275 Adult VirginFemale Spermatheca    140.8 Adult InseminatedFemale Spermatheca    104.3 Adult Ovary    157.3 Adult Testis    29.9 Adult Male Accessory Gland    131.7 Adult Carcass    116.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    101.9 Larval Midgut    91.4 Larval Hindgut    176.5 Larval Malpighian Tubules    299.6 Larval Fat Body    199.9 Larval Salivary Gland    667.2 Larval Trachea    162.725 Larval Carcass    106.8 Adult Head    93.6 Adult Eye    49.4 Adult Brain    54.5 Adult Thoracic-Abdominal Ganglion    57.3 Adult Crop    180.5 Adult Midgut    198.7 Adult Hindgut    239.2 Adult Malpighian Tubules    119.2 Adult Fat Body    124.4 Adult Salivary Gland    179.8 Adult Heart    86.275 Adult VirginFemale Spermatheca    140.8 Adult InseminatedFemale Spermatheca    104.3 Adult Ovary    157.3 Adult Testis    29.9 Adult Male Accessory Gland    131.7 Adult Carcass    116.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    101.9 Larval Midgut    91.4 Larval Hindgut    176.5 Larval Malpighian Tubules    299.6 Larval Fat Body    199.9 Larval Salivary Gland    667.2 Larval Trachea    162.725 Larval Carcass    106.8 Adult Head    93.6 Adult Eye    49.4 Adult Brain    54.5 Adult Thoracic-Abdominal Ganglion    57.3 Adult Crop    180.5 Adult Midgut    198.7 Adult Hindgut    239.2 Adult Malpighian Tubules    119.2 Adult Fat Body    124.4 Adult Salivary Gland    179.8 Adult Heart    86.275 Adult VirginFemale Spermatheca    140.8 Adult InseminatedFemale Spermatheca    104.3 Adult Ovary    157.3 Adult Testis    29.9 Adult Male Accessory Gland    131.7 Adult Carcass    116.5 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    101.9 Larval Midgut    91.4 Larval Hindgut    176.5 Larval Malpighian Tubules    299.6 Larval Fat Body    199.9 Larval Salivary Gland    667.2 Larval Trachea    162.725 Larval Carcass    106.8 Adult Head    93.6 Adult Eye    49.4 Adult Brain    54.5 Adult Thoracic-Abdominal Ganglion    57.3 Adult Crop    180.5 Adult Midgut    198.7 Adult Hindgut    239.2 Adult Malpighian Tubules    119.2 Adult Fat Body    124.4 Adult Salivary Gland    179.8 Adult Heart    86.275 Adult VirginFemale Spermatheca    140.8 Adult InseminatedFemale Spermatheca    104.3 Adult Ovary    157.3 Adult Testis    29.9 Adult Male Accessory Gland    131.7 Adult Carcass    116.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    101.9 Larval Midgut    91.4 Larval Hindgut    176.5 Larval Malpighian Tubules    299.6 Larval Fat Body    199.9 Larval Salivary Gland  667.2 Larval Trachea    162.725 Larval Carcass    106.8 Adult Head    93.6 Adult Eye    49.4 Adult Brain    54.5 Adult Thoracic-Abdominal Ganglion    57.3 Adult Crop    180.5 Adult Midgut    198.7 Adult Hindgut    239.2 Adult Malpighian Tubules    119.2 Adult Fat Body    124.4 Adult Salivary Gland    179.8 Adult Heart    86.275 Adult VirginFemale Spermatheca    140.8 Adult InseminatedFemale Spermatheca    104.3 Adult Ovary    157.3 Adult Testis    29.9 Adult Male Accessory Gland    131.7 Adult Carcass    116.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    101.9 Larval Midgut    91.4 Larval Hindgut    176.5 Larval Malpighian Tubules    299.6 Larval Fat Body    199.9 Larval Salivary Gland    667.2 Larval Trachea    162.725 Larval Carcass    106.8 Adult Head    93.6 Adult Eye    49.4 Adult Brain    54.5 Adult Thoracic-Abdominal Ganglion    57.3 Adult Crop    180.5 Adult Midgut    198.7 Adult Hindgut    239.2 Adult Malpighian Tubules    119.2 Adult Fat Body    124.4 Adult Salivary Gland    179.8 Adult Heart    86.275 Adult VirginFemale Spermatheca    140.8 Adult InseminatedFemale Spermatheca    104.3 Adult Ovary    157.3 Adult Testis    29.9 Adult Male Accessory Gland    131.7 Adult Carcass    116.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    101.9 Larval Midgut    91.4 Larval Hindgut    176.5 Larval Malpighian Tubules    299.6 Larval Fat Body    199.9 Larval Salivary Gland    667.2 Larval Trachea    162.725 Larval Carcass    106.8 Adult Head    93.6 Adult Eye    49.4 Adult Brain    54.5 Adult Thoracic-Abdominal Ganglion    57.3 Adult Crop    180.5 Adult Midgut    198.7 Adult Hindgut    239.2 Adult Malpighian Tubules    119.2 Adult Fat Body    124.4 Adult Salivary Gland    179.8 Adult Heart    86.275 Adult VirginFemale Spermatheca    140.8 Adult InseminatedFemale Spermatheca    104.3 Adult Ovary    157.3 Adult Testis    29.9 Adult Male Accessory Gland    131.7 Adult Carcass    116.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    93.6   NA  Eye    49.4   NA  Brain    54.5   101.9  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    57.3   NA  Crop    180.5   91.4  Midgut    198.7   176.5  Hindgut    239.2   299.6  Malpighian Tubules    119.2   199.9  Fat Body    124.4   667.2  Salivary Gland    179.8   NA  Heart    86.275   162.725  Trachea    NA   NA  VirginFemale Spermatheca    140.8   NA  InseminatedFemale Spermatheca    104.3   NA  Ovary    157.3   NA  Testis    29.9   NA  Male Accessory Gland    131.7   106.8  Carcass    116.5 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    27 central nervous system, pupae P8    25 head, virgin 1-day female    11 head, virgin 4-day female    14 head, virgin 20-day female    10 head, mated 1-day female    13 head, mated 4-day female    13 head, mated 20-day female    11 head, mated 1-day male    18 head, mated 4-day male    20 head, mated 20-day male    19 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    7 digestive system, 4-day adult    11 digestive system, 20-day adult    9 fat body, larvae L3 wandering    13 fat body, white prepupae    18 fat body, pupae P8    9 carcass, larvae L3 wandering    15 carcass, 1-day adult    7 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female    14 ovary, mated 4-day female    19 testis, mated 4-day male    3 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3  (27) central nervous system, pupae P8    25 head, virgin 1-day female    11 head, virgin 4-day female    14 head, virgin 20-day female    10 head, mated 1-day female    13 head, mated 4-day female    13 head, mated 20-day female    11 head, mated 1-day male    18 head, mated 4-day male    20 head, mated 20-day male    19 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    7 digestive system, 4-day adult    11 digestive system, 20-day adult    9 fat body, larvae L3 wandering    13 fat body, white prepupae    18 fat body, pupae P8    9 carcass, larvae L3 wandering    15 carcass, 1-day adult    7 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female    14 ovary, mated 4-day female    19 testis, mated 4-day male    3 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    27 central nervous system, pupae P8    25 head, virgin 1-day female    11 head, virgin 4-day female    14 head, virgin 20-day female    10 head, mated 1-day female    13 head, mated 4-day female    13 head, mated 20-day female    11 head, mated 1-day male    18 head, mated 4-day male    20 head, mated 20-day male    19 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    7 digestive system, 4-day adult    11 digestive system, 20-day adult    9 fat body, larvae L3 wandering    13 fat body, white prepupae    18 fat body, pupae P8    9 carcass, larvae L3 wandering    15 carcass, 1-day adult    7 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female    14 ovary, mated 4-day female    19 testis, mated 4-day male    3 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    27 central nervous system, pupae P8    25 head, virgin 1-day female    11 head, virgin 4-day female    14 head, virgin 20-day female    10 head, mated 1-day female    13 head, mated 4-day female    13 head, mated 20-day female    11 head, mated 1-day male    18 head, mated 4-day male    20 head, mated 20-day male    19 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    7 digestive system, 4-day adult    11 digestive system, 20-day adult    9 fat body, larvae L3 wandering    13 fat body, white prepupae    18 fat body, pupae P8    9 carcass, larvae L3 wandering    15 carcass, 1-day adult    7 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female    14 ovary, mated 4-day female    19 testis, mated 4-day male    3 accessory gland, mated 4-day male    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    27 central nervous system, pupae P8    25 head, virgin 1-day female    11 head, virgin 4-day female    14 head, virgin 20-day female    10 head, mated 1-day female    13 head, mated 4-day female    13 head, mated 20-day female    11 head, mated 1-day male    18 head, mated 4-day male    20 head, mated 20-day male    19 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    7 digestive system, 4-day adult    11 digestive system, 20-day adult    9 fat body, larvae L3 wandering    13 fat body, white prepupae    18 fat body, pupae P8    9 carcass, larvae L3 wandering    15 carcass, 1-day adult    7 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female    14 ovary, mated 4-day female    19 testis, mated 4-day male    3 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3  27 central nervous system, pupae P8    25 head, virgin 1-day female    11 head, virgin 4-day female    14 head, virgin 20-day female    10 head, mated 1-day female    13 head, mated 4-day female    13 head, mated 20-day female    11 head, mated 1-day male    18 head, mated 4-day male    20 head, mated 20-day male    19 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    7 digestive system, 4-day adult    11 digestive system, 20-day adult    9 fat body, larvae L3 wandering    13 fat body, white prepupae    18 fat body, pupae P8    9 carcass, larvae L3 wandering    15 carcass, 1-day adult    7 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female    14 ovary, mated 4-day female    19 testis, mated 4-day male    3 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    27 central nervous system, pupae P8    25 head, virgin 1-day female    11 head, virgin 4-day female    14 head, virgin 20-day female    10 head, mated 1-day female    13 head, mated 4-day female    13 head, mated 20-day female    11 head, mated 1-day male    18 head, mated 4-day male    20 head, mated 20-day male    19 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    7 digestive system, 4-day adult    11 digestive system, 20-day adult    9 fat body, larvae L3 wandering    13 fat body, white prepupae    18 fat body, pupae P8    9 carcass, larvae L3 wandering    15 carcass, 1-day adult    7 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female    14 ovary, mated 4-day female    19 testis, mated 4-day male    3 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    27 central nervous system, pupae P8    25 head, virgin 1-day female    11 head, virgin 4-day female    14 head, virgin 20-day female    10 head, mated 1-day female    13 head, mated 4-day female    13 head, mated 20-day female    11 head, mated 1-day male    18 head, mated 4-day male    20 head, mated 20-day male    19 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    7 digestive system, 4-day adult    11 digestive system, 20-day adult    9 fat body, larvae L3 wandering    13 fat body, white prepupae    18 fat body, pupae P8    9 carcass, larvae L3 wandering    15 carcass, 1-day adult    7 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female    14 ovary, mated 4-day female    19 testis, mated 4-day male    3 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    11 embryo 04-06hr    24 embryo 06-08hr    22 embryo 08-10hr    17 embryo 10-12hr    16 embryo 12-14hr    16 embryo 14-16hr    18 embryo 16-18hr    14 embryo 18-20hr    14 embryo 20-22hr    9 embryo 22-24hr    8 larva L1    7 larva L2    5 larva L3 12hr old    5 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    9 white prepupae new    11 white prepupae 12hr    13 white prepupae 24hr    14 pupae 2d postWPP    9 pupae 3d postWPP    7 pupae 4d postWPP    6 adult male 01day    8 adult male 05day    8 adult male 30day    8 adult female 01day    9 adult female 05day    10 adult female 30day    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    11 embryo 04-06hr    24 embryo 06-08hr    22 embryo 08-10hr    17 embryo 10-12hr    16 embryo 12-14hr    16 embryo 14-16hr    18 embryo 16-18hr    14 embryo 18-20hr    14 embryo 20-22hr    9 embryo 22-24hr    8 larva L1    7 larva L2    5 larva L3 12hr old    5 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    9 white prepupae new    11 white prepupae 12hr    13 white prepupae 24hr    14 pupae 2d postWPP    9 pupae 3d postWPP    7 pupae 4d postWPP    6 adult male 01day    8 adult male 05day    8 adult male 30day    8 adult female 01day    9 adult female 05day    10 adult female 30day    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    11 embryo 04-06hr    24 embryo 06-08hr    22 embryo 08-10hr    17 embryo 10-12hr    16 embryo 12-14hr    16 embryo 14-16hr    18 embryo 16-18hr    14 embryo 18-20hr    14 embryo 20-22hr    9 embryo 22-24hr    8 larva L1    7 larva L2    5 larva L3 12hr old    5 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    9 white prepupae new    11 white prepupae 12hr    13 white prepupae 24hr    14 pupae 2d postWPP    9 pupae 3d postWPP    7 pupae 4d postWPP    6 adult male 01day    8 adult male 05day    8 adult male 30day    8 adult female 01day    9 adult female 05day    10 adult female 30day    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    11 embryo 04-06hr    24 embryo 06-08hr    22 embryo 08-10hr    17 embryo 10-12hr    16 embryo 12-14hr    16 embryo 14-16hr    18 embryo 16-18hr    14 embryo 18-20hr    14 embryo 20-22hr    9 embryo 22-24hr    8 larva L1    7 larva L2    5 larva L3 12hr old    5 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    9 white prepupae new    11 white prepupae 12hr    13 white prepupae 24hr    14 pupae 2d postWPP    9 pupae 3d postWPP    7 pupae 4d postWPP    6 adult male 01day    8 adult male 05day    8 adult male 30day    8 adult female 01day    9 adult female 05day    10 adult female 30day    11 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    11 embryo 04-06hr    24 embryo 06-08hr    22 embryo 08-10hr    17 embryo 10-12hr    16 embryo 12-14hr    16 embryo 14-16hr    18 embryo 16-18hr    14 embryo 18-20hr    14 embryo 20-22hr    9 embryo 22-24hr    8 larva L1    7 larva L2    5 larva L3 12hr old    5 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    9 white prepupae new    11 white prepupae 12hr    13 white prepupae 24hr    14 pupae 2d postWPP    9 pupae 3d postWPP    7 pupae 4d postWPP    6 adult male 01day    8 adult male 05day    8 adult male 30day    8 adult female 01day    9 adult female 05day    10 adult female 30day    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    11 embryo 04-06hr    24 embryo 06-08hr    22 embryo 08-10hr    17 embryo 10-12hr    16 embryo 12-14hr    16 embryo 14-16hr    18 embryo 16-18hr    14 embryo 18-20hr    14 embryo 20-22hr    9 embryo 22-24hr    8 larva L1    7 larva L2    5 larva L3 12hr old    5 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    9 white prepupae new    11 white prepupae 12hr    13 white prepupae 24hr    14 pupae 2d postWPP    9 pupae 3d postWPP    7 pupae 4d postWPP    6 adult male 01day    8 adult male 05day    8 adult male 30day    8 adult female 01day    9 adult female 05day    10 adult female 30day    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    11 embryo 04-06hr    24 embryo 06-08hr    22 embryo 08-10hr    17 embryo 10-12hr    16 embryo 12-14hr    16 embryo 14-16hr    18 embryo 16-18hr    14 embryo 18-20hr    14 embryo 20-22hr    9 embryo 22-24hr    8 larva L1    7 larva L2    5 larva L3 12hr old    5 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    9 white prepupae new    11 white prepupae 12hr    13 white prepupae 24hr    14 pupae 2d postWPP    9 pupae 3d postWPP    7 pupae 4d postWPP    6 adult male 01day    8 adult male 05day    8 adult male 30day    8 adult female 01day    9 adult female 05day    10 adult female 30day    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    11 embryo 04-06hr    24 embryo 06-08hr    22 embryo 08-10hr    17 embryo 10-12hr    16 embryo 12-14hr    16 embryo 14-16hr    18 embryo 16-18hr    14 embryo 18-20hr    14 embryo 20-22hr    9 embryo 22-24hr    8 larva L1    7 larva L2    5 larva L3 12hr old    5 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    9 white prepupae new    11 white prepupae 12hr    13 white prepupae 24hr    14 pupae 2d postWPP    9 pupae 3d postWPP    7 pupae 4d postWPP    6 adult male 01day    8 adult male 05day    8 adult male 30day    8 adult female 01day    9 adult female 05day    10 adult female 30day    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    5 embryonic 1182-4H    6 embryonic GM2    5 embryonic Kc167    3 embryonic S1    12 embryonic S3    2 leg disc CME L1    7 wing disc CME-W2    2 wing disc ML-DmD8    5 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    14 wing disc ML-DmD21    15 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    46 eye-antennal disc ML-DmD11    5 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    7 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    8 tumorous blood cells mbn2    6 ovary fGS/OSS    17 ovary OSC    25 ovary OSS    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    5 embryonic 1182-4H    6 embryonic GM2    5 embryonic Kc167    3 embryonic S1    12 embryonic S3    2 leg disc CME L1    7 wing disc CME-W2    2 wing disc ML-DmD8    5 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    14 wing disc ML-DmD21    15 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3  (46) eye-antennal disc ML-DmD11    5 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    7 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    8 tumorous blood cells mbn2    6 ovary fGS/OSS    17 ovary OSC    25 ovary OSS    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    5 embryonic 1182-4H    6 embryonic GM2    5 embryonic Kc167    3 embryonic S1    12 embryonic S3    2 leg disc CME L1    7 wing disc CME-W2    2 wing disc ML-DmD8    5 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    14 wing disc ML-DmD21    15 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    46 eye-antennal disc ML-DmD11    5 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    7 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    8 tumorous blood cells mbn2    6 ovary fGS/OSS    17 ovary OSC    25 ovary OSS    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    5 embryonic 1182-4H    6 embryonic GM2    5 embryonic Kc167    3 embryonic S1    12 embryonic S3    2 leg disc CME L1    7 wing disc CME-W2    2 wing disc ML-DmD8    5 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    14 wing disc ML-DmD21    15 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    46 eye-antennal disc ML-DmD11    5 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    7 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    8 tumorous blood cells mbn2    6 ovary fGS/OSS    17 ovary OSC    25 ovary OSS    14 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    5 embryonic 1182-4H    6 embryonic GM2    5 embryonic Kc167    3 embryonic S1    12 embryonic S3    2 leg disc CME L1    7 wing disc CME-W2    2 wing disc ML-DmD8    5 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    14 wing disc ML-DmD21    15 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    46 eye-antennal disc ML-DmD11    5 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    7 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    8 tumorous blood cells mbn2    6 ovary fGS/OSS    17 ovary OSC    25 ovary OSS    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    5 embryonic 1182-4H    6 embryonic GM2    5 embryonic Kc167    3 embryonic S1    12 embryonic S3    2 leg disc CME L1    7 wing disc CME-W2    2 wing disc ML-DmD8    5 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    14 wing disc ML-DmD21    15 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3  (46) eye-antennal disc ML-DmD11    5 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    7 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    8 tumorous blood cells mbn2    6 ovary fGS/OSS    17 ovary OSC    25 ovary OSS    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    5 embryonic 1182-4H    6 embryonic GM2    5 embryonic Kc167    3 embryonic S1    12 embryonic S3    2 leg disc CME L1    7 wing disc CME-W2    2 wing disc ML-DmD8    5 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    14 wing disc ML-DmD21    15 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    46 eye-antennal disc ML-DmD11    5 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    7 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    8 tumorous blood cells mbn2    6 ovary fGS/OSS    17 ovary OSC    25 ovary OSS    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    5 embryonic 1182-4H    6 embryonic GM2    5 embryonic Kc167    3 embryonic S1    12 embryonic S3    2 leg disc CME L1    7 wing disc CME-W2    2 wing disc ML-DmD8    5 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    14 wing disc ML-DmD21    15 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    46 eye-antennal disc ML-DmD11    5 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    7 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    8 tumorous blood cells mbn2    6 ovary fGS/OSS    17 ovary OSC    25 ovary OSS    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    11 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    14 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    11 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    14 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    11 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    14 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    11 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    14 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    11 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    14 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    11 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    14 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    11 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    14 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    11 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    14 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_30 mE1_20_mRNA_expression_cluster_09
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003175 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4444-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | recessive pxk08134 pxk08316 viable pxe02948 pxEY03862 pxEY10083 pxEY10541 pxT190-202 viable, with Scer\GAL4pnr-MD237 pxGD11318 Sterility Allele fertile pxe02948 pxEY03862 pxEY10083 pxEY10541 Other Phenotypes Allele behavior defective | recessive pxBG02217 visible px1 px2 px52g px54h px55k pxe02948 pxhb246 visible, with Scer\GAL4C-765 pxScer\UAS.cMa visible | recessive px1 px72 visible | recessive | somatic clone px72 wild-type pxhs.PM Phenotype manifest in Allele eye px1 leg px1 wing px1 px2 px52g px54h px55k px72 pxM1 pxM2 pxM3 pxM4 pxM5 pxM6 pxhb246 wing, with Scer\GAL4C-765 pxScer\UAS.cMa wing, with Scer\GAL4ptc-559.1 pxScer\UAS.cMa wing vein px1 px72 pxM1 pxM2 pxM3 pxM4 pxM5 pxM6 pxe02948 wing vein | ectopic px1 px72 pxhb246 wing vein | ectopic | somatic clone px72
Classical Alleles ( 54 )
For All Classical Alleles Show
Allele of px Class Mutagen Stocks Known lesion px1 spontaneous 66 -- pxe02948 piggyBac transposase 2 -- pxk08316 P-element activity 2 -- px5-HA-1422 1 -- pxA130.1F2 P-element activity 1 Yes pxc03342 1 -- pxc04083 1 -- pxc04958 piggyBac transposase 1 -- pxc06385 piggyBac transposase 1 -- pxc06408 piggyBac transposase 1 -- pxc06572 1 -- pxd00474 P-element activity 1 -- pxd01959 P-element activity 1 -- pxEY03862 P-element activity 1 -- pxEY10083 P-element activity 1 -- pxf00418 piggyBac transposase 1 -- pxf03306 piggyBac transposase 1 -- pxf04768 piggyBac transposase 1 -- pxf06534 piggyBac transposase 1 -- pxMB02577 1 -- pxMI00080 1 -- px01D01W-L043 0 -- px01D01W-L053 0 -- px01D01W-L147 0 -- px01D01W-L198 0 -- px19 0 -- px2 spontaneous 0 -- px45j natural population 0 -- px52g X ray 0 Yes px54h spontaneous 0 -- px55k spontaneous 0 -- px70 spontaneous 0 -- px72 loss of function allele, hypomorphic allele - genetic evidence 0 Yes pxBG00631 P-element activity 0 -- pxBG02217 0 -- pxc01821 piggyBac transposase 0 -- pxc03225 0 -- pxc05044 piggyBac transposase 0 -- pxc05653 piggyBac transposase 0 -- pxCB-5060-3 0 -- pxd05539 P-element activity 0 -- pxDG29811 P-element activity 0 -- pxEY10541 P-element activity 0 -- pxf02152 piggyBac transposase 0 -- pxhb246 hobo activity 0 Yes pxk08134 P-element activity 0 -- pxM1 0 -- pxM2 0 -- pxM3 0 -- pxM4 0 -- pxM5 0 -- pxM6 0 -- pxT190-202 P-element activity 0 Yes pxunspecified 0 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of px Class Mutagen Stocks Known lesion pxGD11318 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes pxhs.PM in vitro construct - regulatory fusion 0 Yes pxNIG.4444R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes pxScer\UAS.cMa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Duplicated in	Dp(2;3)P
Not disrupted in	Df(2R)59AB (BDGP Project Members, 1994-1999) Df(2R)59AD (BDGP Project Members, 1994-1999) Df(2R)02311 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2R)E3578 (BDGP Project Members, 1994-1999) Df(2R)X58-7 (BDGP Project Members, 1994-1999)
Disrupted in	Df(2R)M58F (Bridges, 1937, Dunn and Mossige, 1937) Df(2R)P (Bridges, 1937) Df(2R)X58-6 (Kerrebrock et al., 1992) In(2LR)px52g (Matakatsu et al., 1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11318} NA P{NIG.4444R} NA P{UAS-px.M} NA heat-shock construct P{hs-px.M} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}pxk08134 No P{lacW}pxk08316 No P{lArB}pxA130.1F2 No insertion of mobile activating element P{EPgy2}pxEY03862 NA P{EPgy2}pxEY10083 NA P{EPgy2}pxEY10541 NA P{GSV1}EP-575EP-575 NA P{Mae-UAS.6.11}B0377B0377 NA P{XP}pxd00474 NA P{XP}pxd01959 NA P{XP}pxd03821 NA P{XP}pxd05539 NA miscellaneous insertions H{}pxhb246 NA Mi{MIC}pxMI00080 NA P{5'wHy}px01D01W-L043 NA P{5'wHy}px01D01W-L053 NA P{5'wHy}px01D01W-L147 NA P{5'wHy}px01D01W-L198 NA P{GT1}pxBG00631 NA P{GT1}pxBG02217 NA P{RS3}pxCB-5060-3 NA P{RS5}px5-HA-1422 NA P{T1}pxT190-202 NA P{wHy}pxDG29811 NA PBac{PB}pxc01821 NA PBac{PB}pxc03225 NA PBac{PB}pxc03342 NA PBac{PB}pxc04083 NA PBac{PB}pxc04958 NA PBac{PB}pxc05044 NA PBac{PB}pxc05653 NA PBac{PB}pxc06385 NA PBac{PB}pxc06408 NA PBac{PB}pxc06572 NA PBac{RB}pxe02948 NA PBac{WH}pxf00418 NA PBac{WH}pxf02152 NA PBac{WH}pxf03306 NA PBac{WH}pxf04768 NA PBac{WH}pxf06534 NA insertion of enhancer trap binary system Mi{ET1}pxMB02577 No
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
imaginal disc-derived wing vein morphogenesis inferred from mutant phenotype (Matakatsu et al., 1999) inter-male aggressive behavior inferred from mutant phenotype (Edwards et al., 2009)
Cellular Component
CV term Evidence References
nuclear matrix inferred from direct assay (Matakatsu et al., 1999)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
imaginal disc-derived wing vein morphogenesis traceable author statement (de Celis, 2003)
Cellular Component
CV term Evidence References
nucleoplasm non-traceable author statement (Hayashi, 1999.9.6)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions px allele Gene References px1 Dl (Wessendorf et al., 1992) Egfr (Diaz-Benjumea and Garcia-Bellido, 1990) H (Johannes and Preiss, 2002) if (Wessendorf et al., 1992) N (Wessendorf et al., 1992) nmo (Verheyen et al., 2001) os (Bach et al., 2003) rho (Wessendorf et al., 1992) slt (Curry, 1939) px19 Dl (Klein and Campos-Ortega, 1992) px72 bs (Roch et al., 1998, Matakatsu et al., 1999) emc (Baonza and Garcia-Bellido, 1999) rho (Wessendorf et al., 1992) Snr1 (Marenda et al., 2004) pxk08134 peb (Wilk et al., 2004) pxk08316 os (Bach et al., 2003) peb (Wilk et al., 2004) pxunspecified ast (Lewis, 1945) S (Lewis, 1945) unspecified ast   aya (Suzuki et al., 2000) Cb   Egfr (Read et al., 2005) Ret (Read et al., 2005) rho (Sturtevant and Bier, 1995)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 63189 DroID - A comprehensive database of gene and protein interactions. • FBgn0003175 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37573
Orthologs
OrthoDB Orthologs (30) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6RV39R Dipteran inclusive ortholog search EOG62RDGB Insect inclusive ortholog search EOG69P8TC Arthropod inclusive ortholog search EOG6M0CGK Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6RV39R)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\px     Drosophila melanogaster fruit fly  Dmel\Bacc     Drosophila simulans   Dsim\GD25124 Y Y Drosophila erecta   Dere\GG21786 Y Y Drosophila yakuba   Dyak\GE11861 Y Y Drosophila ananassae   Dana\GF13017 Y Y Drosophila ananassae   Dana\GF19131   Y Drosophila pseudoobscura pseudoobscura   Dpse\GA24382   Y Drosophila persimilis   Dper\GL10478   Y Drosophila willistoni   Dwil\GK22138 Y Y Drosophila virilis   Dvir\GJ20397   Y Drosophila mojavensis   Dmoj\GI18600 Y Y Drosophila grimshawi   Dgri\GH21424 Y Y
Orthologs in non-Drosophila Dipterans (EOG62RDGB)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL000591 Y Anopheles gambiae Malaria mosquito  Agam\AGAP001608 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ007308 Y
Orthologs in non-Dipteran Insects (EOG69P8TC)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB52975 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH15823 Y Atta cephalotes Leafcutter ant  Acep\ACEP11044 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO18527 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19117 Y Linepithema humile Argentine ant  Lhum\LH17872 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB14218 Y Solenopsis invicta Red fire ant  Sinv\SINV19042 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI001179 Y Bombyx mori Silkmoth  Bmor\BGIBMGA013671 Y Pediculus humanus Human body louse  Phum\PHUM204580 Y Tribolium castaneum Red flour beetle  Tcas\TC008852 Y
Orthologs in non-Insect Arthropods (EOG6M0CGK)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\dam8 Y Ixodes scapularis Deer tick  Isca\ISCW000854 Y
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (7) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD25124 Drosophila erecta Dere\GG21786 Drosophila yakuba Dyak\GE11861 Drosophila ananassae Dana\GF13017 Drosophila willistoni Dwil\GK22138 Drosophila mojavensis Dmoj\GI18600 Drosophila grimshawi Dgri\GH21424
Stocks & Reagents
Stocks Listed in FlyBase ( 90 )
Bloomington	377 px1
Harvard	- P{XP}pxd00474 - P{XP}pxd01959 - PBac{PB}pxc03342 - PBac{PB}pxc04083 - PBac{PB}pxc04958 - PBac{PB}pxc06385 - PBac{PB}pxc06408 - PBac{PB}pxc06572 - PBac{RB}pxe02948 - PBac{WH}pxf00418
Kyoto	105879 px1
	More stocks available...
Genomic Clones ( 2 )
	BACR01E01 BACR48M13 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 82 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT16518 IP16954 SD01586
Other clones	FI16805
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	HL08018 LP14201 RE53343 RE53388 RH23635 RH32203 SD08646 SD18278 SD18366 SD25761 SD26717 SD27283
Other clones	12307 19071 29888 31343 38838 51242 54128 61641 81397 97023 100550 103435 120446 121957 158977 159276 214213.67 214213.68 214507.72 214539.39 274270 569121 CK01.58B.F2 CK01.61A.D11 CK01.79D.H5 CK01.109B.E6 Dmel_neb_011878_0070_2876 EC052497 EC053488 EC053626 EC053740 EC054343 EC055476 EC056589 EK046953 EK061931 EK098851 EK113142 EK132116 EK140247 EK177148 EK185035 EK215127 EK215304 EK223241 EK238626 EK242062 EK243011 EK261627 EK262415 EK266555 EK291851 EK301734 EN01344 EN02948 EN14559 EP01356 EP02928 EP04353 EP13954 EP19011 EP19210 IP16854 IP17054 IP17154 LD11785
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0003175 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37573
Antibody Information
	polyclonal (Matakatsu et al., 1999)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: px CG4444 (Milshina, 1999.11)
Source for database merge of	Source for merge of: l(2)k08316 l(2)k08134 (Spradling et al., 1999) Source for merge of: px l(2)k08316 (Levis, 2001.2.19)
Additional comments
Other Comments
	px encodes an essential component of a global repressor of vein differentiation. px acts downstream of kni. (Matakatsu et al., 1999) Mutations in px allow ectopic venation in the intervein regions of the wing. (Matakatsu et al., 1999) The px gene product may regulate transcription of vein and intervein genes by tethering transcriptional regulators to specific locations in the nucleus. (Matakatsu et al., 1999) Extra vein mutations cause enhancement of rhohs.PSt ectopic vein phenotype and suppression of the rhove-1 loss of vein phenotype. (Sturtevant and Bier, 1995) Mutants display hyperplastic phenotype, showing tissue overgrowth in mitotic recombination clones. (Mechler, 1994) A screen that identified Dominant enhancers of the wing phenotype associated with Dl9P and DlFE32 identified one new px allele. (Klein and Campos-Ortega, 1992) Mutations in px cause extra longitudinal or transverse veins with plexated vein phenotypes. Px, px, net, dsr and emc belong to the same synergistic group and act synergistically against kn, fu and shf. (Diaz-Benjumea and Garcia-Bellido, 1990) Px, net, dsr, px and emc loci belong to the plexus phenotypic group within the 'excess-of-vein' mutant class. Extra veins occur parallel to and between normal veins that connect to each other by crossveins, forming plexi. Plexi are distal. Proximal regions shift to the margin leaving a central area devoid of veins. Sensilla and chaetae appear shifted. Combinations of mutations produce superadditive phenotypes. (Diaz-Benjumea et al., 1989)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_166535 NM_001103947 NM_001274206 NM_001274207 RefSeq (Proteins) • NP_726208 NP_001097417 NP_001261135 NP_001261136 DDBJ / EMBL / GenBank • AAF46855 AAL13982 AB032181 ABV53884 ABV53885 AGB93666 AGB93667 AI530850 AQ025858 AQ034014 AW944190 AY058753 BAA86717 CL527722 CL528203 CL844327 CZ467475 CZ469640 CZ469704 CZ469705 CZ470157 CZ470650 CZ470651 CZ470670 CZ471622 CZ472532 CZ472533 CZ474591 CZ480715 CZ482884 CZ482885 CZ484654 CZ485850 CZ487328 CZ489242 Entrez Gene - A searchable database of RefSeq genes. • 37573 UniProtKB/TrEMBL • A8DYM2 A8DYM3 Q9U8Q0 Q9W244 Q95TI5
Other Crossreferences
Linkouts
	BioGRID - A database of protein and genetic interactions • 63189 DroID - A comprehensive database of gene and protein interactions. • FBgn0003175 DRSC - Results from RNAi screens. • FBgn0003175 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003175 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4444-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0003175 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37573 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37573 modMine - Data generated by the modENCODE project. • FBgn0003175
Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	CG4444 (Molnar et al., 2006, Grieder et al., 2007) l(2)k08134   l(2)k08316 (Li et al., 2003, Spradling, 1999.12.9, Spradling et al., 1999, ) px (Haynes et al., 2006, Molnar et al., 2006, Grieder et al., 2007, Whitlock and Bourguet, 2000, Levis et al., 2011.12.16, Franciscovich et al., 2008, Terriente-Félix and de Celis, 2009, Beltran et al., 2007, Japanese National Institute of Genetics, 2012.5.21)
Name Synonym	plexus (Hayashi, 1999.9.6, Whitlock and Bourguet, 2000, Turner et al., 2011, Edwards et al., 2009, Maclellan et al., 2012)
Secondary FlyBase IDs
	FBgn0022042 FBgn0022054
References ( 121 )
Generate a list of	All references relating to this gene ( 121 )
List References by type	Research paper  ( 75 ) Supplementary material  ( 6 ) Review  ( 8 ) Personal communication to FlyBase  ( 16 ) Abstract  ( 6 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Stock list  ( 1 ) Curated genome annotation  ( 2 ) Book  ( 3 )
Recent research papers ( 5 )
	Housden et al., 2013, PLoS Genet. 9(1): e1003162 Transcriptional Dynamics Elicited by a Short Pulse of Notch Activation Involves Feed-Forward Regulation by E(spl)/Hes Genes. [FBrf0220474] Arbuthnott and Rundle, 2012, Evolution 66(7): 2127--2137 Sexual selection is ineffectual or inhibits the purging of deleterious mutations in Drosophila melanogaster. [FBrf0218756] Maclellan et al., 2012, Heredity 108(3): 203--210 Dietary stress does not strengthen selection against single deleterious mutations in Drosophila melanogaster. [FBrf0217530] Weber et al., 2012, PLoS ONE 7(4): e34745 Genome-Wide Association Analysis of Oxidative Stress Resistance in Drosophila melanogaster. [FBrf0218073] Turner et al., 2011, PLoS Genet. 7(3): e1001336 Population-Based Resequencing of Experimentally Evolved Populations Reveals the Genetic Basis of Body Size Variation in Drosophila melanogaster. [FBrf0213327] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...