Gene Dmel\Px

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General Information

Symbol

Dmel\Px

Species

D. melanogaster

Name

Plexate

Annotation symbol

Feature type

gene

FlyBase ID

FBgn0003176

Gene Model Status

Unannotated

Stock availability

None publicly available

Genomic Location

Chromosome (arm)

Recombination map

2-107.2

Cytogenetic map

60C6-60D1

Sequence location

Summary Information

Automatically generated summary

See sections below for more information

The gene Plexate is referred to in FlyBase by the symbol Dmel\Px (FBgn0003176). It is a gene from Drosophila melanogaster. Its molecular function is unknown. The biological processes in which it is involved are not known. 7 alleles are reported. No phenotypic data is available. It has no annotated transcripts. Gene has not been localized to the genome sequence.

User Contributed Data

Beta version, feedback welcome

Phenotypic Description from the Red Book (Lindsley & Zimm 1992)

Gene/Allele symbols may differ from current usage

Px: Plexate

Px: Plexate
From "Edith M. Wallace, unpublished."

Wing veins of heterozygote with plexuslike or delta-like thickenings, most often near posterior crossvein, and free fragments of vein, most often in third posterior cell; L4 vein bent near margin. Wings smaller and narrower than wild type and dusky textured. Closely resembles bs. Expression more extreme in female; enhanced by cold (19). Homozygous Df(2R)Px lethal as embryo (Li, 1927, Genetics 12: 1-58); Df(2R)Px2 cell lethal (Ripoll and Garcia-Bellido, 1979, Genetics 91: 443-53). Mutants asssociated with deficiencies near tip of 2R.

Recent Updates

Description

What does this section display?

This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).

What does this section not display?

This section does not currently display links that were removed or gene model changes.

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FB2013_03

FB2013_02

All updates

Click here to see a list of all updates to this record from FB2010_08 and on.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

60C6-60D1

Left limit from inclusion within Df(2R)Px5 (FBrf0015196) Right limit from inclusion within Df(2R)Px5 (FBrf0015196)

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-107.2

Left of (cM)

Right of (cM)

Notes

Map position approximate.

Gene Model & Products

Comments on Gene Model

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

Additional Polypeptide Data & Comments

Reported size (kDa)

Comments

External Data

Linkouts

Crossreferences

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Mapped Features

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization (GO Cellular Component)

CV term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

Reference

See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

FlyAtlas Anatomy Microarray

modENCODE Anatomy RNA-Seq

modENCODE Development RNA-Seq

modENCODE Cell Lines RNA-Seq

modENCODE Treatments RNA-Seq

Expression Clusters

External Data & Images

Linkouts

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

lethal | recessive

Phenotype manifest in

Allele

Classical Alleles ( 7 )

For All Classical Alleles Show

Allele of Px	Mutagen	Known lesion
Px¹⁰	ethyl methanesulfonate	--
Px¹¹	ethyl methanesulfonate	--
Px⁹	ethyl methanesulfonate	--
Px^D10	ethyl methanesulfonate	--
Px^D123	ethyl methanesulfonate	--
Px^F5	ethyl methanesulfonate	--
Px^F7	ethyl methanesulfonate	--

Alleles Carried on Transgenic Constructs ( 0 )

For All Alleles Carried on Transgenic Constructs Show

Allele of Px	Class	Mutagen	Stocks	Known lesion

Aneuploid Aberrations

Disrupted in

Df(2R)Px5

(Thompson, 1963)

In(2LR)Px⁴

Duplicated in

In(2LR)S^56f

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

Insertions

Type of insertions

Name

Expression data

Gene Ontology: Function, Process & Cellular Component ( 0 unique terms )

Terms Based on Experimental Evidence ( 0 terms )

Terms Based on Predictions or Assertions ( 0 terms )

Sequence Ontology: Class of Gene

gene

Interactions & Pathways

Summary of Physical Interactions

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

Px allele

Gene

References

Px⁹

(Klein and Campos-Ortega, 1992)

Px¹⁰

(Klein and Campos-Ortega, 1992)

Px¹¹

(Klein and Campos-Ortega, 1992)

Px^D10

(Klein and Campos-Ortega, 1992)

unspecified

(Klein and Campos-Ortega, 1992)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0003176

Orthologs

OrthoDB Orthologs (0) - based on analysis using Dmel annotation version 5.41

OrthoDB Ortholog Groups

OrthoDB orthology group searches

(Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288)

Drosophila inclusive ortholog search

No orthologs identified

Dipteran inclusive ortholog search

No orthologs identified

Insect inclusive ortholog search

No orthologs identified

Arthropod inclusive ortholog search

No orthologs identified

Metazoa inclusive ortholog search

No orthologs identified

Orthologs in Drosophila Species (None identified)

No orthologies identified

Orthologs in non-Drosophila Dipterans (None identified)

No non-Drosophilid orthologies identified

Orthologs in non-Dipteran Insects (None identified)

No non-Dipteran orthologies identified

Orthologs in non-Insect Arthropods (None identified)

No non-Insect Arthropod orthologies identified

Orthologs in non-Arthropod Metazoa (None identified)

No non-Arthropod Metazoa orthologies identified

Human Orthologs (0)

Gene

OMIM

HGNC

AAA Orthologs (0) based on analysis using Dmel annotation version 4.3

No orthologs identified

Stocks & Reagents

Stocks Listed in FlyBase ( 0 )

Genomic Clones ( 0 )

cDNA Clones ( 0 )

cDNA Clones, Fully Sequenced

BDGP DGC clones

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Linkouts

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

45918

Antibody Information

Other Information

Discoverer

Bridges, 6th June 1922.

Etymology

Identification

Relationship to Other Genes

Source for database identity of

Source for database merge of

Additional comments

May be part of a pseudoallelic complex with ba and bs.

Other Comments

Haploinsufficient locus (not associated with strong haplolethality or haplosterility).

(Cook et al., 2012)

A screen that identified Dominant enhancers of the wing phenotype associated with Dl^9P and Dl^FE32 identified 7 new Px alleles.

(Klein and Campos-Ortega, 1992)

Px, net, dsr, px and emc loci belong to the plexus phenotypic group within the 'excess-of-vein' mutant class. Extra veins occur parallel to and between normal veins that connect to each other by crossveins forming plexi. Plexi are distal. Proximal regions shift to the margin leaving a central area devoid of veins. Sensilla and chaetae appear shifted. Combinations of mutations produce superadditive phenotypes.

(Diaz-Benjumea et al., 1989)

Dominant loss of function phenotype seen in Df(2R)Px1 (FBab0002026) Df(2R)Px2 (FBab0002027), Df(2R)Px5 (FBab0002028) and In(2LR)Px⁴ (FBab0004789).

Wing veins of heterozygote with plexus-like or delta-like thickenings, most often near posterior crossvein and free fragments of vein, most often in third posterior cell; L4 vein bent near margin. Wings smaller and narrower than wild type and dusky textured. Closely resembles bs. Expression more extreme in female; enhanced by cold (19[o]).

External Crossreferences & Linkouts

Sequence Crossreferences

Other Crossreferences

Linkouts

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0003176

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

45918

Synonyms & Secondary IDs ( 2 )

Reported As

Symbol Synonym

(Cook et al., 2012)

Name Synonym

Plexate

(Cook et al., 2012)

Secondary FlyBase IDs

References ( 17 )

Research paper

Cook et al., 2012, Genome Biol. 13(3): R21: The generation of chromosomal deletions to provide extensive coverage and subdivision of the Drosophila melanogaster genome. [FBrf0219066]
Greaves et al., 1999, Genetics 153(4): 1753--1766: A screen for identifying genes interacting with armadillo, the Drosophila homolog of beta-catenin. [FBrf0123026]
Klein and Campos-Ortega, 1992, Rouxs Arch. Dev. Biol. 202(1): 49--60: Second-site modifiers of the Delta wing phenotype in Drosophila melanogaster. [FBrf0057610]
Gridley et al., 1990, Development 109: 235--242: Molecular analysis of the Mov 34 mutation: transcript disrupted by proviral integration in mice is conserved in Drosophila. [FBrf0051560]
Kimble et al., 1990, Genetics 126: 991--1005: The -3-tubulin gene of Drosophila melanogaster is essential for viability and fertility. [FBrf0051997]
Diaz-Benjumea et al., 1989, Genome 31(2): 612--619: Developmental genetics of the wing vein pattern of Drosophila. [FBrf0050002]
Ripoll and Garcia-Bellido, 1979, Genetics 91: 443--453: Viability of homozygous deficiencies in somatic cells of Drosophila melanogaster. [FBrf0033184]
Lindsley et al., 1972, Genetics 71: 157--184: Segmental aneuploidy and the genetic gross structure of the Drosophila genome. [FBrf0023910]
Seattle-La Jolla Drosophila Laboratories, 1971, D. I. S. 47(Suppl.): 7pp: The use of Y-autosome translocations in the construction of autosomal duplications and deficiencies. (Special supplement to DIS 47). [FBrf0022239]
Thompson, 1963, D. I. S. 38: 28: [New mutants report.] [FBrf0015196]
Burdick, 1956, D. I. S. 30: 69: [New mutants report.] [FBrf0010759]
Bridges, 1937, Cytologia Fujii Jubil. Vol.: 745--755: Correspondences between linkage maps and salivary chromosome structure as illustrated in the tip of chromosome 2R of Drosophila melanogaster. [FBrf0003816]
Li, 1927, Genetics 12: 1--58: The effect of chromosome aberrations on development in Drosophila melanogaster. [FBrf0001565]

Review

Crozatier et al., 2004, Trends Genet. 20(10): 498--505: Patterns in evolution: veins of the Drosophila wing. [FBrf0179903]
Klingenberg, 2002, Gene 287(1-2): 3--10: Morphometrics and the role of the phenotype in studies of the evolution of developmental mechanisms. [FBrf0148999]

Abstract

Kraut and Campos-Ortega, 1993, Davis, Zipursky, 1993: 44: inscuteable: analysis of a neurally expressed enhancer-trap line reveals functions in wing and CNS. [FBrf0078831]

Book

Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster.: The Genome of Drosophila melanogaster. [FBrf0066905]