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Gene Dmel\qua

General Information
Symbol	Dmel\qua	Species	D. melanogaster
Name	quail	Annotation symbol	CG6433
Feature type	protein_coding_gene	FlyBase ID	FBgn0003187
Gene Model Status	Current	Stock availability	17 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map	2-53
Cytogenetic map	36C10-36C10	Sequence location	2L:17,486,806..17,497,208 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene quail is referred to in FlyBase by the symbol Dmel\qua (CG6433, FBgn0003187). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: actin binding. There is experimental evidence that it is involved in the biological process: ovarian nurse cell to oocyte transport; actin filament organization; imaginal disc-derived wing hair organization. 40 alleles are reported. The phenotypes of these alleles are annotated with: organ system; multicellular structure; anatomical structure; ovariole; multi-tissue structure; organelle; adult segment; spindle; acellular anatomical structure; female organism; organ system subdivision; portion of tissue. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Villin headpiece; Villin/Gelsolin. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed during late pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult ovary, adult testis. Expression at moderate levels in the following post-embryonic organs or tissues: adult crop. Comments on Affy2 ProbeSet: ProbeSet 1634526_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of qua. Gene sequence location is 2L:17486806..17497208.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	fs(2)A12 Homozygous females anatomically normal; lay foreshortened eggs with truncated anterior tip and short fat chorionic filaments. Eggs similar to stage-11 oocytes, some with adhering follicle and nurse cells. A few eggs lack stainable chromatin; most have one to three large spherical masses of fragmented chromosomes or tripolar spindles and abnormally elongated mitotic figures. qua: quail (T. Schupbach) Female sterile; nurse-cell contents not transported into the egg; follicle cells produce normal chorion around tiny eggs, which remain unfertilized.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02	Controlled Vocabulary Terms actin filament cytoplasm
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 36C10-36C10   Limits computationally determined from genome sequence between P{lacW}Aac11k06710 and P{EP}CG10413EP2164
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location	2-53 (Tearle and Nusslein-Volhard, 1987) 2- (Bakken, 1973)
Left of (cM)
Right of (cM)	dl (Tearle and Nusslein-Volhard, 1987)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\qua for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.49 Low-frequency RNA-Seq exon junction(s) not annotated. Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) qua-RA FBtr0080996  NM_165222   3266   887 qua-RB FBtr0080997  NM_165223   3306   888 qua-RC FBtr0306165  NM_001259137   3318   892
Additional Transcript Data & Comments
Reported size (kB)	3.3 (northern blot) (Mahajan-Miklos and Cooley, 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein qua-PA   FBpp0080549   100.9   887   7.96     NP_724060   AAF53623 qua-PB   FBpp0080550   101.0   888   7.70     NP_724061   AAN10991 qua-PC   FBpp0297295   101.5   892   7.84     NP_001246066   AFH03740
Additional Polypeptide Data & Comments
Reported size (kDa)	887 (aa); 97 (kD observed); 97 (kD predicted) (Mahajan-Miklos and Cooley, 1994)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Villin headpiece (IPR003128) Villin/Gelsolin (IPR007122)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014134 AAF53623   AE014134 AAN10991   AE014134 AFH03740   AI516331   AX154722   AY121684 AAM52011   BF488360   BG639036   BI163090   BI164389   BI164477   BI240178   BI363930   BI365486   BT100209   CL610126   CO191785   CO194469   CZ467029   CZ478283   CZ478313   CZ478314   CZ482524   DU635320   EC052474   EC056991   EC079859   ES688870   EV576171   GH774786   GH777129   GH778931   GH782491   GH789847   GH794911   GH923625   GH939208   U10070 AAC13765
UniProtKB/Swiss-Prot	Q23989
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   pole cell   (Fisher et al., 2012) embryonic stage 7 -- 8   pole cell   (Fisher et al., 2012) embryonic stage 9 -- 10   germline cell   (Fisher et al., 2012) embryonic stage 11 -- 12   dorsal epidermis primordium   (Fisher et al., 2012) gnathal primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   atrium   (Fisher et al., 2012) embryonic dorsal epidermis   (Fisher et al., 2012) embryonic epipharynx   (Fisher et al., 2012) embryonic foregut   (Fisher et al., 2012) embryonic head epidermis   (Fisher et al., 2012) embryonic hindgut   (Fisher et al., 2012) embryonic hypopharynx   (Fisher et al., 2012) embryonic ventral epidermis   (Fisher et al., 2012) embryonic/larval lymph gland   (Fisher et al., 2012) germline cell   (Fisher et al., 2012) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 9     (Mahajan-Miklos and Cooley, 1994) Comment:reference states 0-4 hr AEL pupal stage     (Mahajan-Miklos and Cooley, 1994) adult stage | female   ovary   (Mahajan-Miklos and Cooley, 1994) adult stage & oogenesis   oocyte   (Mahajan-Miklos and Cooley, 1994) nurse cell   (Mahajan-Miklos and Cooley, 1994) spermatogenesis & adult stage   testis   (Mahajan-Miklos and Cooley, 1994)
Additional Descriptive Data
	qua transcripts are abundant in male testes and female ovaries and in early embyros and are detected at very low levels at other times of development by northern blots. qua transcripts are detected in nurse cells and in the oocyte by in situ hybridization. (Mahajan-Miklos and Cooley, 1994)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference adult stage & oogenesis   nurse cell   (Mahajan-Miklos and Cooley, 1994) ring canal   (Mahajan-Miklos and Cooley, 1994) oocyte   (Mahajan-Miklos and Cooley, 1994)
Additional Descriptive Data
	In oocyte stages S8-S10A, qua protein colocalizes with the subcortical actin filament network in the nurse cells and the oocyte. It is also present in the cytoplasm of nurse cells. Occasionally, it localizes to ring canals. In stage S10B, the levels of qua protein rise significantly and it is found along the length of the newly assembled actin filament bundles in the nurse cell cytoplasm. (Mahajan-Miklos and Cooley, 1994)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
colocalizes_with actin filament inferred from direct assay (Mahajan-Miklos and Cooley, 1994) cytoplasm inferred from direct assay (Mahajan-Miklos and Cooley, 1994)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult ovary, adult testis. Expression at moderate levels in the following post-embryonic organs or tissues: adult crop. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    1.95 Larval Midgut    84.1 Larval Hindgut    1.7 Larval Malpighian Tubules    2.2 Larval Fat Body    55.7 Larval Salivary Gland    1.8 Larval Trachea    10.325 Larval Carcass    1.35 Adult Head    4.5 Adult Eye    4.175 Adult Brain    0.6 Adult Thoracic-Abdominal Ganglion    2 Adult Crop    327.2 Adult Midgut    5.1 Adult Hindgut    59 Adult Malpighian Tubules    4.5 Adult Fat Body    5.1 Adult Salivary Gland    91.9 Adult Heart    1.05 Adult VirginFemale Spermatheca    9.7 Adult InseminatedFemale Spermatheca    19.8 Adult Ovary    521.3 Adult Testis    688.2 Adult Male Accessory Gland    6.9 Adult Carcass    6.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    1.95 Larval Midgut    84.1 Larval Hindgut    1.7 Larval Malpighian Tubules    2.2 Larval Fat Body    55.7 Larval Salivary Gland    1.8 Larval Trachea    10.325 Larval Carcass    1.35 Adult Head    4.5 Adult Eye    4.175 Adult Brain    0.6 Adult Thoracic-Abdominal Ganglion    2 Adult Crop    327.2 Adult Midgut    5.1 Adult Hindgut    59 Adult Malpighian Tubules    4.5 Adult Fat Body    5.1 Adult Salivary Gland    91.9 Adult Heart    1.05 Adult VirginFemale Spermatheca    9.7 Adult InseminatedFemale Spermatheca    19.8 Adult Ovary  521.3 Adult Testis  (688.2) Adult Male Accessory Gland    6.9 Adult Carcass    6.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    1.95 Larval Midgut    84.1 Larval Hindgut    1.7 Larval Malpighian Tubules    2.2 Larval Fat Body    55.7 Larval Salivary Gland    1.8 Larval Trachea    10.325 Larval Carcass    1.35 Adult Head    4.5 Adult Eye    4.175 Adult Brain    0.6 Adult Thoracic-Abdominal Ganglion    2 Adult Crop    327.2 Adult Midgut    5.1 Adult Hindgut    59 Adult Malpighian Tubules    4.5 Adult Fat Body    5.1 Adult Salivary Gland    91.9 Adult Heart    1.05 Adult VirginFemale Spermatheca    9.7 Adult InseminatedFemale Spermatheca    19.8 Adult Ovary    521.3 Adult Testis    688.2 Adult Male Accessory Gland    6.9 Adult Carcass    6.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1.95 Larval Midgut    84.1 Larval Hindgut    1.7 Larval Malpighian Tubules    2.2 Larval Fat Body    55.7 Larval Salivary Gland    1.8 Larval Trachea    10.325 Larval Carcass    1.35 Adult Head    4.5 Adult Eye    4.175 Adult Brain    0.6 Adult Thoracic-Abdominal Ganglion    2 Adult Crop    327.2 Adult Midgut    5.1 Adult Hindgut    59 Adult Malpighian Tubules    4.5 Adult Fat Body    5.1 Adult Salivary Gland    91.9 Adult Heart    1.05 Adult VirginFemale Spermatheca    9.7 Adult InseminatedFemale Spermatheca    19.8 Adult Ovary    521.3 Adult Testis    688.2 Adult Male Accessory Gland    6.9 Adult Carcass    6.7 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    1.95 Larval Midgut    84.1 Larval Hindgut    1.7 Larval Malpighian Tubules    2.2 Larval Fat Body    55.7 Larval Salivary Gland    1.8 Larval Trachea    10.325 Larval Carcass    1.35 Adult Head    4.5 Adult Eye    4.175 Adult Brain    0.6 Adult Thoracic-Abdominal Ganglion    2 Adult Crop    327.2 Adult Midgut    5.1 Adult Hindgut    59 Adult Malpighian Tubules    4.5 Adult Fat Body    5.1 Adult Salivary Gland    91.9 Adult Heart    1.05 Adult VirginFemale Spermatheca    9.7 Adult InseminatedFemale Spermatheca    19.8 Adult Ovary    521.3 Adult Testis    688.2 Adult Male Accessory Gland    6.9 Adult Carcass    6.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    1.95 Larval Midgut    84.1 Larval Hindgut    1.7 Larval Malpighian Tubules    2.2 Larval Fat Body    55.7 Larval Salivary Gland    1.8 Larval Trachea    10.325 Larval Carcass    1.35 Adult Head    4.5 Adult Eye    4.175 Adult Brain    0.6 Adult Thoracic-Abdominal Ganglion    2 Adult Crop    327.2 Adult Midgut    5.1 Adult Hindgut    59 Adult Malpighian Tubules    4.5 Adult Fat Body    5.1 Adult Salivary Gland    91.9 Adult Heart    1.05 Adult VirginFemale Spermatheca    9.7 Adult InseminatedFemale Spermatheca    19.8 Adult Ovary  521.3 Adult Testis  688.2 Adult Male Accessory Gland    6.9 Adult Carcass    6.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    1.95 Larval Midgut    84.1 Larval Hindgut    1.7 Larval Malpighian Tubules    2.2 Larval Fat Body    55.7 Larval Salivary Gland    1.8 Larval Trachea    10.325 Larval Carcass    1.35 Adult Head    4.5 Adult Eye    4.175 Adult Brain    0.6 Adult Thoracic-Abdominal Ganglion    2 Adult Crop    327.2 Adult Midgut    5.1 Adult Hindgut    59 Adult Malpighian Tubules    4.5 Adult Fat Body    5.1 Adult Salivary Gland    91.9 Adult Heart    1.05 Adult VirginFemale Spermatheca    9.7 Adult InseminatedFemale Spermatheca    19.8 Adult Ovary    521.3 Adult Testis    688.2 Adult Male Accessory Gland    6.9 Adult Carcass    6.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1.95 Larval Midgut    84.1 Larval Hindgut    1.7 Larval Malpighian Tubules    2.2 Larval Fat Body    55.7 Larval Salivary Gland    1.8 Larval Trachea    10.325 Larval Carcass    1.35 Adult Head    4.5 Adult Eye    4.175 Adult Brain    0.6 Adult Thoracic-Abdominal Ganglion    2 Adult Crop    327.2 Adult Midgut    5.1 Adult Hindgut    59 Adult Malpighian Tubules    4.5 Adult Fat Body    5.1 Adult Salivary Gland    91.9 Adult Heart    1.05 Adult VirginFemale Spermatheca    9.7 Adult InseminatedFemale Spermatheca    19.8 Adult Ovary    521.3 Adult Testis    688.2 Adult Male Accessory Gland    6.9 Adult Carcass    6.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    4.5   NA  Eye    4.175   NA  Brain    0.6   1.95  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    2   NA  Crop    327.2   84.1  Midgut    5.1   1.7  Hindgut    59   2.2  Malpighian Tubules    4.5   no informative data  Fat Body    5.1   1.8  Salivary Gland    91.9   NA  Heart    1.05   no informative data  Trachea    NA   NA  VirginFemale Spermatheca    9.7   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    521.3   NA  Testis    688.2   NA  Male Accessory Gland    6.9   1.35  Carcass    6.7 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    1 central nervous system, pupae P8    3 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    15 carcass, larvae L3 wandering    2 carcass, 1-day adult    1 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    37 ovary, mated 4-day female    31 testis, mated 4-day male    33 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    1 central nervous system, pupae P8    3 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    15 carcass, larvae L3 wandering    2 carcass, 1-day adult    1 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female  (37) ovary, mated 4-day female  (31) testis, mated 4-day male  (33) accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    1 central nervous system, pupae P8    3 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    15 carcass, larvae L3 wandering    2 carcass, 1-day adult    1 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    37 ovary, mated 4-day female    31 testis, mated 4-day male    33 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    1 central nervous system, pupae P8    3 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    15 carcass, larvae L3 wandering    2 carcass, 1-day adult    1 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    37 ovary, mated 4-day female    31 testis, mated 4-day male    33 accessory gland, mated 4-day male    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    1 central nervous system, pupae P8    3 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    15 carcass, larvae L3 wandering    2 carcass, 1-day adult    1 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    37 ovary, mated 4-day female    31 testis, mated 4-day male    33 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    1 central nervous system, pupae P8    3 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    15 carcass, larvae L3 wandering    2 carcass, 1-day adult    1 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female  (37) ovary, mated 4-day female  31 testis, mated 4-day male  (33) accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    1 central nervous system, pupae P8    3 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    15 carcass, larvae L3 wandering    2 carcass, 1-day adult    1 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    37 ovary, mated 4-day female    31 testis, mated 4-day male    33 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    1 central nervous system, pupae P8    3 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    15 carcass, larvae L3 wandering    2 carcass, 1-day adult    1 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    37 ovary, mated 4-day female    31 testis, mated 4-day male    33 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed during late pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    48 embryo 02-04hr    8 embryo 04-06hr    2 embryo 06-08hr    2 embryo 08-10hr    5 embryo 10-12hr    19 embryo 12-14hr    42 embryo 14-16hr    37 embryo 16-18hr    18 embryo 18-20hr    6 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    2 larva L2    6 larva L3 12hr old    3 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    6 white prepupae 12hr    9 white prepupae 24hr    15 pupae 2d postWPP    75 pupae 3d postWPP    16 pupae 4d postWPP    12 adult male 01day    25 adult male 05day    30 adult male 30day    29 adult female 01day    11 adult female 05day    27 adult female 30day    28 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (48) embryo 02-04hr    8 embryo 04-06hr    2 embryo 06-08hr    2 embryo 08-10hr    5 embryo 10-12hr    19 embryo 12-14hr  (42) embryo 14-16hr  (37) embryo 16-18hr    18 embryo 18-20hr    6 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    2 larva L2    6 larva L3 12hr old    3 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    6 white prepupae 12hr    9 white prepupae 24hr    15 pupae 2d postWPP  (75) pupae 3d postWPP    16 pupae 4d postWPP    12 adult male 01day    25 adult male 05day  (30) adult male 30day  (29) adult female 01day    11 adult female 05day  (27) adult female 30day  (28) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    48 embryo 02-04hr    8 embryo 04-06hr    2 embryo 06-08hr    2 embryo 08-10hr    5 embryo 10-12hr    19 embryo 12-14hr    42 embryo 14-16hr    37 embryo 16-18hr    18 embryo 18-20hr    6 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    2 larva L2    6 larva L3 12hr old    3 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    6 white prepupae 12hr    9 white prepupae 24hr    15 pupae 2d postWPP    75 pupae 3d postWPP    16 pupae 4d postWPP    12 adult male 01day    25 adult male 05day    30 adult male 30day    29 adult female 01day    11 adult female 05day    27 adult female 30day    28 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    48 embryo 02-04hr    8 embryo 04-06hr    2 embryo 06-08hr    2 embryo 08-10hr    5 embryo 10-12hr    19 embryo 12-14hr    42 embryo 14-16hr    37 embryo 16-18hr    18 embryo 18-20hr    6 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    2 larva L2    6 larva L3 12hr old    3 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    6 white prepupae 12hr    9 white prepupae 24hr    15 pupae 2d postWPP    75 pupae 3d postWPP    16 pupae 4d postWPP    12 adult male 01day    25 adult male 05day    30 adult male 30day    29 adult female 01day    11 adult female 05day    27 adult female 30day    28 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    48 embryo 02-04hr    8 embryo 04-06hr    2 embryo 06-08hr    2 embryo 08-10hr    5 embryo 10-12hr    19 embryo 12-14hr    42 embryo 14-16hr    37 embryo 16-18hr    18 embryo 18-20hr    6 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    2 larva L2    6 larva L3 12hr old    3 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    6 white prepupae 12hr    9 white prepupae 24hr    15 pupae 2d postWPP    75 pupae 3d postWPP    16 pupae 4d postWPP    12 adult male 01day    25 adult male 05day    30 adult male 30day    29 adult female 01day    11 adult female 05day    27 adult female 30day    28 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (48) embryo 02-04hr    8 embryo 04-06hr    2 embryo 06-08hr    2 embryo 08-10hr    5 embryo 10-12hr    19 embryo 12-14hr  (42) embryo 14-16hr  (37) embryo 16-18hr    18 embryo 18-20hr    6 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    2 larva L2    6 larva L3 12hr old    3 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    6 white prepupae 12hr    9 white prepupae 24hr    15 pupae 2d postWPP  (75) pupae 3d postWPP    16 pupae 4d postWPP    12 adult male 01day    25 adult male 05day  30 adult male 30day  29 adult female 01day    11 adult female 05day  27 adult female 30day  28 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    48 embryo 02-04hr    8 embryo 04-06hr    2 embryo 06-08hr    2 embryo 08-10hr    5 embryo 10-12hr    19 embryo 12-14hr    42 embryo 14-16hr    37 embryo 16-18hr    18 embryo 18-20hr    6 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    2 larva L2    6 larva L3 12hr old    3 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    6 white prepupae 12hr    9 white prepupae 24hr    15 pupae 2d postWPP    75 pupae 3d postWPP    16 pupae 4d postWPP    12 adult male 01day    25 adult male 05day    30 adult male 30day    29 adult female 01day    11 adult female 05day    27 adult female 30day    28 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    48 embryo 02-04hr    8 embryo 04-06hr    2 embryo 06-08hr    2 embryo 08-10hr    5 embryo 10-12hr    19 embryo 12-14hr    42 embryo 14-16hr    37 embryo 16-18hr    18 embryo 18-20hr    6 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    2 larva L2    6 larva L3 12hr old    3 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    6 white prepupae 12hr    9 white prepupae 24hr    15 pupae 2d postWPP    75 pupae 3d postWPP    16 pupae 4d postWPP    12 adult male 01day    25 adult male 05day    30 adult male 30day    29 adult female 01day    11 adult female 05day    27 adult female 30day    28 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    1 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    1 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    1 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    1 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    1 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    1 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    1 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    1 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    26 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    22 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    21 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3  26 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    22 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    21 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    26 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    22 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    21 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    26 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    22 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    21 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    26 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    22 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    21 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3  26 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    22 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    21 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    26 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    22 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    21 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    26 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    22 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    21 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_26
External Data & Images
Linkouts	BDGP expression data • RE36860 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003187 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6433-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for qua Stages(s) 4-6 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable quaEY03072 viable, with Scer\GAL4pnr-MD237 quaGD11926 Sterility Allele female sterile qua1 qua8 qua9 qua10 qua11 qua12 female sterile | recessive qua1 qua6-396 qua8-1012 qua8-1028 qua8-1062 qua8-1306 qua8 qua9-134 qua10 qua11 qua12 female sterile | recessive | heat sensitive quaWP614 fertile quaEY03072 Other Phenotypes Allele mitotic cell cycle defective | recessive qua6-396 qua8-1012 qua8-1028 qua8-1062 qua8-1306 qua9-134 wild-type quaGerm.WT quaHsp26.PK Phenotype manifest in Allele actin filament & egg chamber qua1 dorsal appendage qua1 qua6-396 qua8-1012 qua8-1028 qua8-1062 qua8-1306 qua9 qua9-134 egg qua1 qua6-396 qua8-1012 qua8-1028 qua8-1062 qua8-1306 qua9-134 egg chamber qua1 qua10 qua11 qua12 qua8 female reproductive system qua6-396 qua8-1012 qua8-1028 qua8-1062 qua8-1306 qua9-134 nurse cell qua1 nurse cell & actin filament quaWP614 quaunspecified nurse cell ring canal qua1 nurse follicle cell qua1 qua10 qua11 qua12 qua8 oocyte qua1 qua10 qua11 qua12 qua8 ovary qua6-396 qua8-1062 spindle qua6-396 qua8-1012 qua8-1028 qua8-1062 qua8-1306 qua9-134 wing hair (with qua1) qua6-396 wing hair (with qua6-396) qua1
Classical Alleles ( 33 )
For All Classical Alleles Show
Allele of qua Class Mutagen Stocks Known lesion qua1 ethyl methanesulfonate 2 -- qua6-396 ethyl methanesulfonate 2 -- qua8-1062 ethyl methanesulfonate 2 -- qua5-HA-2017 1 -- quac01267 piggyBac transposase 1 -- quae00392 piggyBac transposase 1 -- quae00426 piggyBac transposase 1 -- quaEY03072 P-element activity 1 -- quaEY14603 P-element activity 1 -- quaf00039 piggyBac transposase 1 -- quaMI07365 1 -- qua10 ethyl methanesulfonate 0 -- qua11 ethyl methanesulfonate 0 -- qua12 ethyl methanesulfonate 0 -- qua1374 P-element activity 0 Yes qua2 0 -- qua3 0 -- qua4 0 -- qua5-HA-1936 0 -- qua5 0 -- qua6 0 -- qua7 0 -- qua8-1012 ethyl methanesulfonate 0 -- qua8-1028 ethyl methanesulfonate 0 -- qua8-1306 ethyl methanesulfonate 0 -- qua8 ethyl methanesulfonate 0 -- qua9-134 ethyl methanesulfonate 0 -- qua9 ethyl methanesulfonate 0 -- quaDG29711 P-element activity 0 -- quaNP5224 0 -- quaunspecified 0 -- quaWP165 ethyl methanesulfonate 0 -- quaWP614 0 --
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of qua Class Mutagen Stocks Known lesion quaGD11926 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes quaGL01284 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes quaKK103765 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes quaGerm.HL in vitro construct - regulatory fusion 0 Yes quaGerm.WT in vitro construct - regulatory fusion 0 Yes quaHsp26.PK in vitro construct - regulatory fusion 0 Yes quaNIG.6433R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)A92 (Hardy, 2005.6.1) Df(2L)BSC148 (Christensen and Cook, 2006.3.8) Df(2L)Exel7069 (Ryder, 2004.4.26) Df(2L)H20 (Steward and Nusslein-Volhard, 1986, Schupbach and Wieschaus, 1991) Df(2L)H68 (Steward and Nusslein-Volhard, 1986) Df(2L)M36F18 (Steward and Nusslein-Volhard, 1986) Df(2L)qua1374 (Mahajan-Miklos and Cooley, 1994) Df(2L)T317 (Steward and Nusslein-Volhard, 1986) Df(2L)TW119 (Steward and Nusslein-Volhard, 1986, Tearle and Nusslein-Volhard, 1987) Df(2L)TW137 (Bloomington Drosophila Stock Center, 1998.9.22, Schnorrer et al., 2002, Steward and Nusslein-Volhard, 1986, Mahajan-Miklos and Cooley, 1994)
Not disrupted in	Df(2L)GpdhA (Bloomington Drosophila Stock Center, 1998.9.22) Df(2L)M36F-S5 (Bloomington Drosophila Stock Center, 1998.9.22, Steward and Nusslein-Volhard, 1986, Tearle and Nusslein-Volhard, 1987) Df(2L)TW201 (Steward and Nusslein-Volhard, 1986) Df(2L)TW202 (Steward and Nusslein-Volhard, 1986) Df(2L)TW203 (Steward and Nusslein-Volhard, 1986) Df(2L)TW330 (Steward and Nusslein-Volhard, 1986) Df(2L)VA18 (Steward and Nusslein-Volhard, 1986)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11926} NA P{KK103765} NA P{NIG.6433R} NA P{TRiP.GL01284} NA heat-shock construct P{hsp26-quail} NA characterization construct P{quaGerm.HL} NA P{quaGerm.WT} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}quaEY03072 NA P{EPgy2}quaEY14603 NA miscellaneous insertions Mi{MIC}quaMI07365 NA P{RS5}qua5-HA-1936 NA P{RS5}qua5-HA-2017 NA P{wHy}quaDG29711 NA PBac{PB}quac01267 NA PBac{RB}quae00392 NA PBac{RB}quae00426 NA PBac{RB}quae03015 NA PBac{WH}quaf00039 NA insertion of enhancer trap binary system P{GawB}quaNP5224 No
Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
Terms Based on Experimental Evidence ( 6 terms )
Molecular Function
CV term Evidence References
actin binding inferred from direct assay (Matova and Cooley, 1998) inferred from direct assay AND inferred from mutant phenotype AND inferred from sequence or structural similarity with Gel AND inferred from sequence or structural similarity with human VIL1 (Mahajan-Miklos and Cooley, 1994)
Biological Process
CV term Evidence References
actin filament organization inferred from direct assay (Matova and Cooley, 1998) imaginal disc-derived wing hair organization inferred from mutant phenotype (Guild et al., 2005) ovarian nurse cell to oocyte transport inferred from mutant phenotype (Schupbach and Wieschaus, 1991)
Cellular Component
CV term Evidence References
colocalizes_with actin filament inferred from direct assay (Mahajan-Miklos and Cooley, 1994) cytoplasm inferred from direct assay (Mahajan-Miklos and Cooley, 1994)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
actin binding inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) calcium ion binding inferred from sequence or structural similarity with human VIL1 (Mahajan-Miklos and Cooley, 1994)
Biological Process
CV term Evidence References
actin filament bundle assembly non-traceable author statement (Swiss-Prot Project Members, 1997.2.1) actin filament organization non-traceable author statement (Swiss-Prot Project Members, 1997.2.1) traceable author statement (Buszczak and Cooley, 2000) cytoplasmic transport, nurse cell to oocyte non-traceable author statement (Swiss-Prot Project Members, 1997.2.1)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
qua - B52 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) qua - CG11876 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) qua - CG15735 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) qua - CG16753 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) qua - CG1785 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) qua - CG18178 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) qua - CG3689 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) qua - CG43444 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) qua - CG4619 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) qua - CG5746 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) qua - CG6422 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) qua - Hsc70-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) qua - Jupiter anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) qua - Psi anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) qua - Rbp1-like anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) qua - RpL35A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) qua - RpS19b anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) qua - Rrp40 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) qua - Rsf1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) qua - Saf-B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) qua - bocksbeutel anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) qua - clu anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) qua - eIF6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) qua - mRpS24 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) qua - mbo anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) qua - nonA-l anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) qua - vig anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions qua allele Gene References qua9 CycB (Ji et al., 2002) sn (Cant et al., 1998) qua10 CycB (Ji et al., 2002) quaGerm.WT sn (Cant et al., 1998) quaWP165 CycB (Ji et al., 2002)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 61054 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0003187 DroID - A comprehensive database of gene and protein interactions. • FBgn0003187 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35058
Orthologs
OrthoDB Orthologs (28) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6X982J Dipteran inclusive ortholog search EOG6FTW7P Insect inclusive ortholog search EOG6HX3WM Arthropod inclusive ortholog search EOG6573NX Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6X982J)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\qua     Drosophila simulans   Dsim\GD21863 Y   Drosophila sechellia   Dsec\GM17122 Y   Drosophila erecta   Dere\GG21739 Y   Drosophila yakuba   Dyak\GE13128 Y   Drosophila ananassae   Dana\GF15098 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA19589 Y   Drosophila persimilis   Dper\GL15950 Y   Drosophila willistoni   Dwil\GK18228 Y   Drosophila virilis   Dvir\GJ20295 Y   Drosophila mojavensis   Dmoj\GI22399 Y   Drosophila grimshawi   Dgri\GH10154 Y
Orthologs in non-Drosophila Dipterans (EOG6FTW7P)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL000334   Anopheles gambiae Malaria mosquito  Agam\AGAP009232   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ004696
Orthologs in non-Dipteran Insects (EOG6HX3WM)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\qua   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG003280   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH21398   Atta cephalotes Leafcutter ant  Acep\ACEP10935   Camponotus floridanus Florida carpenter ant  Cflo\CFLO19054   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL15992   Linepithema humile Argentine ant  Lhum\LH22583   Pogonomyrmex barbatus Red harvester ant  Pbar\PB10321   Solenopsis invicta Red fire ant  Sinv\SINV14277   Bombyx mori Silkmoth  Bmor\BGIBMGA003119   Pediculus humanus Human body louse  Phum\PHUM507400   Tribolium castaneum Red flour beetle  Tcas\TC013108
Orthologs in non-Insect Arthropods (EOG6573NX)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\emm
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD21863 Drosophila sechellia Dsec\GM17122 Drosophila erecta Dere\GG21739 Drosophila yakuba Dyak\GE13128 Drosophila ananassae Dana\GF15098 Drosophila pseudoobscura pseudoobscura Dpse\GA19589 Drosophila persimilis Dper\GL15950 Drosophila willistoni Dwil\GK18228 Drosophila virilis Dvir\GJ20295 Drosophila mojavensis Dmoj\GI22399 Drosophila grimshawi Dgri\GH10154
Stocks & Reagents
Stocks Listed in FlyBase ( 17 )
Bloomington	4571 qua6-396/SM1 4572 qua8-1062/SM1 41856 y1 v1; P{TRiP.GL01284}attP2
Harvard	- PBac{PB}quac01267 - PBac{RB}quae00392 - PBac{RB}quae00426 - PBac{WH}quaf00039
Kyoto	107801 qua6-396/SM1 107802 qua8-1062/CyO 125527 w1118; P{RS5}qua5-HA-2017
VDRC	v100856 P{KK103765}VIE-260B v27623 w1118; P{GD11926}v27623
	More stocks available...
Genomic Clones ( 1 )
	BACR07M13 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 23 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT02619 RE36860
Other clones	DPiM_RE36860
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT23612 RE02406 RE04055 RE04161 RE48919 RE50819
Other clones	CK01.5D.C5 Dmel_dig_013104_0665_3225 EC32024 EC38624 EC052474 LD42165 RP003154105 RP003196577 RP003247742 RP003324929 RP003346877 RP003471279 RP003556332 RP003599037
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0003187 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35058
Antibody Information
	monoclonal (Mahajan-Miklos and Cooley, 1994)
Other Information
Discoverer
	Wieschaus and Nusslein-Volhard.
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: qua CG6433 (Zhong, 1999.11)
Source for database merge of	Source for merge of: qua anon-WO0140519.71 (FlyBase, 1996-) Source for merge of: qua fs(2)A12 (Bloomington Drosophila Stock Center, 1998.9.22)
Additional comments	Source for merge of qua anon-WO0140519.71 was sequence comparison (date:051113). (FlyBase, 1996-)
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation. (Rogers et al., 2003) qua protein can bind and bundle filamentous actin in vitro, regardless of the concentration of calcium ions. (Matova et al., 1999) Like vertebrate villin, qua product can bundle actin filaments in vitro. (Knowles et al., 1995) The villin-like product of the qua locus is required for the formation of cytoplasmic actin filament bundles in nurse cells, possibly by regulating both the polymerization and organization of actin filaments as has been demonstrated for vertebrate villin in vitro. (Mahajan-Miklos and Cooley, 1994) Mutations at the qua locus cause defects in midoogenesis. (Schupbach and Wieschaus, 1991)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_165222 NM_165223 NM_001259137 RefSeq (Proteins) • NP_724060 NP_724061 NP_001246066 DDBJ / EMBL / GenBank • AAC13765 AAF53623 AAM52011 AAN10991 AFH03740 AX154722 AY121684 BI240178 CL610126 CZ467029 CZ478283 CZ478313 CZ478314 CZ482524 DU635320 U10070 Entrez Gene - A searchable database of RefSeq genes. • 35058 UniProtKB/Swiss-Prot • Q23989
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Villin headpiece (IPR003128) Villin/Gelsolin (IPR007122) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RE36860
Linkouts
	BioGRID - A database of protein and genetic interactions • 61054 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0003187 DroID - A comprehensive database of gene and protein interactions. • FBgn0003187 DRSC - Results from RNAi screens. • FBgn0003187 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003187 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6433-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0003187 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35058 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35058 modMine - Data generated by the modENCODE project. • FBgn0003187
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	anon-WO0140519.71   CG6433 (Goldstein and Gunawardena, 2000, Rogers et al., 2003, Guo et al., 2011, Keleman et al., 2009.8.5, Ni et al., 2010.12.1) fs(2)A12   qua (Reeves and Posakony, 2005, Neuman-Silberberg, 2007, Guild et al., 2005, Gan et al., 2010, Borghese et al., 2006, Formstecher et al., 2005, Buffin and Gho, 2010, Zhai et al., 2010, Habermann et al., 2012, Japanese National Institute of Genetics, 2012.5.21) Qua (Martin et al., 2007)
Name Synonym	female sterile(2)A12   quail (Rogers et al., 2003, Cooley, 1994.5.25, Foley and Cooley, 1998, Matova et al., 1997, Schubiger et al., 1997, Neuman-Silberberg, 2007, Guild et al., 2005, Borghese et al., 2006, Noguchi et al., 2008, Tilney et al., 2004, Snee and Macdonald, 2009, Formstecher et al., 2005, Buffin and Gho, 2010, Zhai et al., 2010) Quail (Lerit and Gavis, 2007, Rogers et al., 2003, Bosveld et al., 2008) villin (Guild et al., 2005, Starr and Han, 2003, Noguchi et al., 2008, Tilney et al., 2004)
Secondary FlyBase IDs
	FBgn0000942 FBgn0044556
References ( 100 )
Generate a list of	All references relating to this gene ( 100 )
List References by type	Research paper  ( 39 ) Supplementary material  ( 6 ) Review  ( 14 ) Personal communication to FlyBase  ( 14 ) Abstract  ( 14 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 1 ) Stock list  ( 2 ) Curated genome annotation  ( 3 ) Protein sequence record  ( 1 ) Website  ( 1 ) Patent  ( 1 ) Book  ( 1 )
Recent research papers ( 2 )
	Habermann et al., 2012, Mol. Cell. Biol. 32(17): 3554--3569 Functional Analysis of Centrosomal Kinase Substrates in Drosophila melanogaster Reveals a New Function of the Nuclear Envelope Component Otefin in Cell Cycle Progression. [FBrf0219185] Guo et al., 2011, Mol. Cell. Biol. 31(4): 639--651 Poly(A) Signals Located near the 5' End of Genes Are Silenced by a General Mechanism That Prevents Premature 3'-End Processing. [FBrf0212905] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...