IMPDH, l(1)G0056, l(1)G0127, l(1)G0388, l(1)G0002
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ras using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\ras in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.
Mutant analysis suggests that GMP synthesis from IMP is an essential process, and that activity of the ras gene product, IMPDH, is regulated in a tissue-specific manner.
ras is but one of four types of mutations belonging to an interrelated complex involved some way in purine metabolism: ras, a nonauxotrophic eye-color mutant; two purine auxotrophs, pur1 and gua1, which complement ras and one another; and ras lethal alleles that fail to complement completely the other three types. The complex shares genetic features with r.
Defective in pteridine synthesis; eye color dark ruby. Appears to affect the level of guanosine triphosphate cyclohydrolase activity; ras alleles exhibit increased activity compared to wild type at pupariation, but decreased activity at eclosion (FBrf0031059). Not a purine auxotroph. Color autonomous in larval optic discs transplanted into wild-type hosts (FBrf0003530). ras1/ras-lethal display ras eye color. Larval Malpighian tubes nearly wildtype; not useful for classification FBrf0005752).
The different temperature sensitive periods for the ras gene product, demonstrated with the rasl1 mutation, indicate tissue-specific activation of a gene at different times during development, although the possibility of activation of preformed polypeptides has not been eliminated.