FB2021_02, released April 13, 2021

Gene: Dmel\Ras64B

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General Information
Symbol
Dmel\Ras64B
Species
D. melanogaster
Name
Ras oncogene at 64B
Annotation Symbol
CG1167
Feature Type
protein_coding_gene
FlyBase ID
FBgn0003206
Gene Model Status
Current
Stock Availability
9 publicly available
Gene Summary
May be involved in endocytic processes and/or other transport pathways mediated by vesicle trafficking. May interact functionally with ROP protein. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. (UniProt, P04388)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

Ras2, Ras, Dras2, ras-2, Dmras64B

Key Links
Genomic Location
Cytogenetic map
64A7-64A7
Sequence location
3L:4,139,076..4,141,398 [+]
Recombination map
3-10
RefSeq locus
NT_037436 REGION:4139076..4141398
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (6 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables protein binding
inferred from physical interaction with FLYBASE:Rgl; FB:FBgn0026376
(Mirey et al., 2003)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables GDP binding
inferred from biological aspect of ancestor with PANTHER:PTN000631348
(assigned by GO_Central )
(Gaudet et al., 2011)
enables GTP binding
inferred from biological aspect of ancestor with PANTHER:PTN000631348
(assigned by GO_Central )
(Gaudet et al., 2011)
enables GTPase activity
inferred from biological aspect of ancestor with PANTHER:PTN000631348
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in Ras protein signal transduction
inferred from biological aspect of ancestor with PANTHER:PTN001529867
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence or structural similarity with MGI:MGI:1914172
(FlyBase Curators, 2008--)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN000631348
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the small GTPase superfamily. Ras family. (P04388)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
RAS GTPASES -
The Ras family are members of the Ras superfamily of small GTPases. Ras proteins act in signal transduction cascades, generally the activated GTPase recruits and activates downstream effectors. Members this family are typically membrane-associated via isoprenylation of a CaaX motif in the C-terminus. (Adapted from PMID:15731001).
Protein Function (UniProtKB)
May be involved in endocytic processes and/or other transport pathways mediated by vesicle trafficking. May interact functionally with ROP protein. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
(UniProt, P04388)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
Ras2
Encodes a 22.7 kilodalton, 195 amino acid, polypeptide, p21.
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Ras64B for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.43

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.45

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Ras64B-RA
FBtr0073212
NM_079193
1620
192
Additional Transcript Data and Comments
Reported size (kB)

1.4 (northern blot)

(Segal and Shilo, 1986)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Ras64B-PA
FBpp0073068
22.2
192
6.76
NP_523917
AAF47845
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts with hzg.

(UniProt, P04388)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ras64B using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
wing disc
(Segal and Shilo, 1986)
genital disc
(Segal and Shilo, 1986)
adult stage
adult brain | restricted
(Segal and Shilo, 1986)
adult ventral nerve cord
(Segal and Shilo, 1986)
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
garland cell
(Salzberg et al., 1993)
(Segal and Shilo, 1986)
antenno-maxillary complex
(Salzberg et al., 1993)
presumptive embryonic/larval central nervous system
(Salzberg et al., 1993)
third instar larval stage
embryonic/larval brain | restricted
(Segal and Shilo, 1986)
eye-antennal disc
(Segal and Shilo, 1986)
adult stage
adult ventral nerve cord
(Segal and Shilo, 1986)
Additional Descriptive Data

Ras64B transcripts are expressed inthe garland cells starting in stage 13 of embryogenesis. They are alsoobserved in the CNS and the antenno-maxillary complex. The pattern is verysimilar to that of Rop. The probe used does not distinguish between thetwo transcripts.

(Salzberg et al., 1993)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Ras64B in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 21 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 22 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Ras64B
Transgenic constructs containing regulatory region of Ras64B
Aberrations (Deficiencies and Duplications) ( 11 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL469B
lethal, with Tn10\tetRtTA.Hsp26
lethal | female, with Tn10\tetRtTA.Yp3
lethal | maternal effect
lethal - all die before end of pupal stage, with Scer\GAL4h-1J3
lethal - all die before end of pupal stage, with Scer\GAL4how-24B
lethal - all die before end of pupal stage | heat sensitive, with Scer\GAL4Ras64B.PW
lethal - all die during embryonic stage | maternal effect
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
abnormal cell polarity
decreased body size | adult stage, with Scer\GAL4Ras64B.PW
some die during embryonic stage | maternal effect
some die during pupal stage, with Scer\GAL4h-1J3
some die during pupal stage, with Scer\GAL4how-24B
some die during pupal stage | heat sensitive, with Scer\GAL4Ras64B.PW
visible
visible, with Scer\GAL430A
visible, with Scer\GAL432B
visible, with Scer\GAL471B
visible, with Scer\GAL4GMR.PF
visible, with Scer\GAL4hs.2sev
visible | dominant
Phenotype manifest in
Allele
anterior sternopleural bristle | maternal effect
dorsal triple row | maternal effect
embryonic head
eye
eye, with Scer\GAL430A
eye, with Scer\GAL432B
eye, with Scer\GAL471B
eye, with Scer\GAL4GMR.PF
eye, with Scer\GAL4hs.2sev
humeral sclerite | maternal effect
lower humeral bristle | maternal effect
medial triple row | maternal effect
middle sternopleural bristle | maternal effect
ommatidium
ommatidium, with Scer\GAL4GMR.PF
ommatidium | maternal effect
photoreceptor cell
photoreceptor cell R1
photoreceptor cell R2
photoreceptor cell R3
photoreceptor cell R4
photoreceptor cell R5
photoreceptor cell R6
photoreceptor cell R7
posterior sternopleural bristle | maternal effect
upper humeral bristle | maternal effect
ventral sternopleural bristle | maternal effect
ventral triple row | maternal effect
wing, with Scer\GAL430A
wing, with Scer\GAL432B
wing, with Scer\GAL471B
wing blade dorsal compartment | maternal effect
wing blade ventral compartment | maternal effect
wing vein | ectopic
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (19)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\RRAS2
13 of 15
Yes
Yes
Hsap\RRAS
9 of 15
No
Yes
Hsap\HRAS
4 of 15
No
No
1  
Hsap\KRAS
4 of 15
No
No
Hsap\NRAS
3 of 15
No
No
Hsap\MRAS
2 of 15
No
Yes
Hsap\RAP1A
2 of 15
No
No
3  
Hsap\RAP1B
2 of 15
No
No
Hsap\ERAS
1 of 15
No
No
Hsap\RALA
1 of 15
No
No
1  
Hsap\RALB
1 of 15
No
No
1  
Hsap\RAP2A
1 of 15
No
No
Hsap\RAP2B
1 of 15
No
No
Hsap\RAP2C
1 of 15
No
No
Hsap\RERG
1 of 15
No
No
Hsap\RHEB
1 of 15
No
No
1  
Hsap\RHEBL1
1 of 15
No
No
Hsap\RIT1
1 of 15
No
No
Hsap\RIT2
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (18)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Rras2
13 of 15
Yes
Yes
Mmus\Rras
9 of 15
No
Yes
Mmus\Kras
4 of 15
No
No
Mmus\Hras
3 of 15
No
No
Mmus\Nras
3 of 15
No
No
Mmus\Mras
2 of 15
No
Yes
Mmus\Rap1a
2 of 15
No
No
Mmus\Rap1b
2 of 15
No
No
Mmus\Eras
1 of 15
No
No
Mmus\Rala
1 of 15
No
No
Mmus\Rap2a
1 of 15
No
No
Mmus\Rap2b
1 of 15
No
No
Mmus\Rap2c
1 of 15
No
No
Mmus\Rerg
1 of 15
No
No
Mmus\Rhebl1
1 of 15
No
No
Mmus\Rheb
1 of 15
No
No
Mmus\Rit1
1 of 15
No
No
Mmus\Rit2
1 of 15
No
No
Rattus norvegicus (Norway rat) (20)
Rnor\Rras2
12 of 13
Yes
Yes
Rnor\Rras
7 of 13
No
Yes
Rnor\Hras
3 of 13
No
No
Rnor\Kras
3 of 13
No
No
Rnor\Nras
3 of 13
No
No
Rnor\LOC367858
2 of 13
No
Yes
Rnor\Mras
2 of 13
No
Yes
Rnor\LOC103690157
1 of 13
No
Yes
Rnor\Rala
1 of 13
No
No
Rnor\Ralb
1 of 13
No
No
Rnor\Rap1a
1 of 13
No
No
Rnor\Rap1b
1 of 13
No
No
Rnor\Rap2a
1 of 13
No
No
Rnor\Rap2b
1 of 13
No
No
Rnor\Rap2c
1 of 13
No
No
Rnor\Rerg
1 of 13
No
No
Rnor\Rhebl1
1 of 13
No
No
Rnor\Rheb
1 of 13
No
No
Rnor\Rit1
1 of 13
No
No
Rnor\Rit2
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (16)
Xtro\rras
7 of 12
Yes
Yes
Xtro\hras
3 of 12
No
No
Xtro\kras
3 of 12
No
No
Xtro\LOC100485959
3 of 12
No
No
Xtro\mras
2 of 12
No
Yes
Xtro\nras
2 of 12
No
No
Xtro\rap1b
2 of 12
No
No
Xtro\rala
1 of 12
No
No
Xtro\rap1a
1 of 12
No
No
Xtro\rap2a
1 of 12
No
No
Xtro\rap2b
1 of 12
No
No
Xtro\rap2c
1 of 12
No
No
Xtro\rerg
1 of 12
No
No
Xtro\rhebl1
1 of 12
No
No
Xtro\rheb
1 of 12
No
No
Xtro\rit1
1 of 12
No
No
Danio rerio (Zebrafish) (23)
Drer\rras2
13 of 15
Yes
Yes
Drer\rras
9 of 15
No
Yes
Drer\hrasa
4 of 15
No
No
Drer\hrasb
4 of 15
No
No
Drer\kras
4 of 15
No
No
Drer\zgc:55558
4 of 15
No
No
Drer\nras
3 of 15
No
No
Drer\mras
2 of 15
No
Yes
Drer\rap1aa
2 of 15
No
No
Drer\rap1ab
2 of 15
No
No
Drer\rap1b
2 of 15
No
No
Drer\si:ch73-116o1.2
2 of 15
No
Yes
Drer\LOC100332969
1 of 15
No
No
Drer\ralaa
1 of 15
No
No
Drer\ralab
1 of 15
No
No
Drer\ralba
1 of 15
No
No
Drer\rap2ab
1 of 15
No
No
Drer\rap2b
1 of 15
No
No
Drer\rap2c
1 of 15
No
No
Drer\rerg
1 of 15
No
No
Drer\rheb
1 of 15
No
No
Drer\rhebl1
1 of 15
No
No
Drer\rit1
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (9)
Cele\ras-1
15 of 15
Yes
Yes
Cele\let-60
4 of 15
No
No
Cele\rap-1
2 of 15
No
No
Cele\ras-2
2 of 15
No
Yes
Cele\ral-1
1 of 15
No
No
Cele\rap-2
1 of 15
No
No
Cele\rap-3
1 of 15
No
No
Cele\rheb-1
1 of 15
No
No
Cele\ZK669.5
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (3)
Atha\GB2
1 of 9
Yes
No
Atha\RABA6a
1 of 9
Yes
Yes
Atha\RABB1a
1 of 9
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (4)
Scer\RAS1
9 of 15
Yes
Yes
Scer\RAS2
8 of 15
No
Yes
Scer\RSR1
2 of 15
No
No
Scer\RHB1
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\ras1
10 of 12
Yes
Yes
Spom\rhb1
1 of 12
No
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190GCZ )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00010041
Drosophila simulans
Dsim\Ras64B
Drosophila sechellia
Dsec\GM14626
Drosophila erecta
Dere\GG15195
Drosophila yakuba
Dyak\GE21414
Drosophila ananassae
Dana\GF10554
Drosophila pseudoobscura pseudoobscura
Dpse\GA11132
Drosophila persimilis
Dper\GL12826
Drosophila willistoni
Dwil\GK12838
Drosophila virilis
Dvir\GJ12824
Drosophila mojavensis
Dmoj\GI16572
Drosophila grimshawi
Dgri\GH15920
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150E21 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17015977
Glossina morsitans
Tsetse fly
Gmor\GMOY003471
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_08938
Mayetiola destructor
Hessian fly
Mdes\Mdes007349
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL002119
Anopheles darlingi
American malaria mosquito
Adar\ADAC006475
Anopheles gambiae
Malaria mosquito
Agam\CLIPD4
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ004306
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0H7C )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA008723
Danaus plexippus
Monarch butterfly
Dple\DPOGS215215-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL009271
Apis florea
Little honeybee
Aflo\4643102100
Apis mellifera
Western honey bee
Amel\LOC409529
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP25137
Bombus terrestris
Buff-tailed bumblebee
Bter\15208235
Linepithema humile
Argentine ant
Lhum\LH12238
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG013647
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_02333
Tribolium castaneum
Red flour beetle
Tcas\TC008799
Pediculus humanus
Human body louse
Phum\PHUM194950
Rhodnius prolixus
Kissing bug
Rpro\RPRC006886
Cimex lectularius
Bed bug
Clec\CLEC003238
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI005579
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_00508
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0GMK )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR009471
Strigamia maritima
European centipede
Smar\SMAR011511
Stegodyphus mimosarum
African social velvet spider
Smim\KFM77725.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur05g07840
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_192739
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_301818
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0UAU )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Rit1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Mras
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_026578gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Adsda
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-RalA
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Kras
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000023365
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000021692
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000021946
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000001900
Gallus gallus
Domestic chicken
Ggal\TM2D3
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000026692
Gallus gallus
Domestic chicken
Ggal\RALA
Gallus gallus
Domestic chicken
Ggal\MRAS
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000026924
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000014647
Gallus gallus
Domestic chicken
Ggal\KRAS
Gallus gallus
Domestic chicken
Ggal\RRAS2
Gallus gallus
Domestic chicken
Ggal\H-RAS
Gallus gallus
Domestic chicken
Ggal\RALB
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (15)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Ras85D
7 of 10
Rap1
4 of 10
Rala
3 of 10
Rap2l
3 of 10
Rheb
3 of 10
Ric
3 of 10
CG8500
2 of 10
CG13375
2 of 10
CG5160
1 of 10
CG8519
1 of 10
CG8641
1 of 10
CG14669
1 of 10
CG30158
1 of 10
κB-Ras
1 of 10
Rgk3
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    RRAS2; RAS related 2
    model of  Noonan syndrome 12
    IEA
    (FlyBase, 2019-)
    Modifiers Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Interaction
    References
    Ras64BGD1517
    ameliorates  autosomal dominant cerebellar ataxia
    modeled by Hsap\ATXN182Q.UAS
    (Park et al., 2013)
    ameliorates  Huntington's disease
    modeled by @Huntington's??not a valid allele symbol??@, @disease??not a valid allele symbol??@
    (Miller et al., 2012)
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    RRAS2; RAS related 2
    13 of 15
    600098
    RRAS; RAS related
    9 of 15
    165090
        HRAS; HRas proto-oncogene, GTPase
        4 of 15
        190020
         
        KRAS; KRAS proto-oncogene, GTPase
        4 of 15
        190070
        NRAS; NRAS proto-oncogene, GTPase
        3 of 15
        164790
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        Summary of Genetic Interactions
        esyN Network Diagram
        esyN Network Key:
        Suppression
        Enhancement
        View in Interactions Browser
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Ras64B
        suppressible
        aos
        (Strutt and Strutt, 2003)
        Ras64B
        enhanceable
        cno
        (Matsuo et al., 1997)
        Ras64B
        suppressible
        dpp
        (de Celis, 1997)
        Ras64B
        suppressible
        Ras85D
        (Strutt and Strutt, 2003)
        Ras64B
        suppressible
        sty
        (Strutt and Strutt, 2003)
        Ras64B
        enhanceable
        tkv
        (de Celis, 1997)
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        14-3-3ε
        suppressible
        Ras64B
        (Yang and Terman, 2012)
        foxo
        suppressible
        Ras64B
        (Kramer et al., 2003)
        PlexA
        suppressible
        Ras64B
        (Yang and Terman, 2012)
        Zdhhc8
        enhanceable
        Ras64B
        (Strassburger et al., 2019)
        External Data
        Subunit Structure (UniProtKB)
        Interacts with hzg.
        (UniProt, P04388 )
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Linkouts
        KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        3L
        Recombination map
        3-10
        Cytogenetic map
        64A7-64A7
        Sequence location
        3L:4,139,076..4,141,398 [+]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        64A7-64A7
        Limits computationally determined from genome sequence between P{PZ}l(3)rG166rG166 and P{PZ}sinu06524
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        64A10-64A11
        (determined by in situ hybridisation)
        (Harrison et al., 1995)
        64B-64B
        (determined by in situ hybridisation)
        (Bishop and Corces, 1988, Brock, 1987, Mozer et al., 1985, Neuman-Silberberg et al., 1984)
        Experimentally Determined Recombination Data
        Location

        3-10

        (FlyBase, 2016)

        3-8.9

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (9)
        Genomic Clones (16)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (53)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of

        Source for identity of: Ras64B CG1167

        (Shue, 1999.11)
        Source for database merge of

        Source for merge of: Ras64B BcDNA:RE36103

        (FlyBase, 1996-)
        Additional comments

        Source for merge of Ras64B BcDNA:RE36103 was a shared cDNA ( date:030728 ).

        (FlyBase, 1996-)
        Other Comments

        dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

        (Kiger et al., 2003)

        One of a class of genes with TATA-less promoters that have a subset of the conserved DPE sequence.

        (Burke and Kadonaga, 1996)

        Discussed during genetic analysis of the Ras64B-Rop region.

        (Harrison et al., 1995)

        Ras64B/Rop bidirectional promoter supports the transcription of both genes. Mobility shift assays indicate the binding of a single major protein complex to the Ras64B/Rop promoter.

        (Lightfoot et al., 1994)

        Expression of an activated form of Ras64B results in dominant eye and wing defects.

        (Brand and Perrimon, 1993)

        Ras64B is divergently transcribed from Rop, and the two transcription units are only 93 bases apart. Based on sequence similarities with related interacting proteins in yeast, it is suggested that Rop and Ras2 gene products are not simply coexpressed, but may interact with each other.

        (Salzberg et al., 1993)

        Ras64B has been cloned and sequenced.

        (Brock, 1987)
        Origin and Etymology
        Discoverer
        Etymology
        Identification
        External Crossreferences and Linkouts ( 54 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
        Other crossreferences
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        modMine - A data warehouse for the modENCODE project
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DPiM - Drosophila Protein interaction map
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        FlyMine - An integrated database for Drosophila genomics
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Synonyms and Secondary IDs (23)
        Reported As
        Symbol Synonym
        BcDNA:RE36103
        C-ras2
        CG1167
        (Hosono et al., 2015, Cammarato et al., 2011, Li et al., 2010, Keleman et al., 2009.8.5, Perkins et al., 2009, Walker et al., 2006, Colicelli, 2004)
        D-ras-2
        (Pribyl et al., 1988)
        D-ras2
        (de Celis and Garcia-Bellido, 1994)
        DRas2
        (Harrison, 1994.10.14)
        Dm-ras-64B
        Dmras64B
        (Brock, 1987)
        Dras2
        (Andolfatto, 2001, Andolfatto and Przeworski, 2001, Aquadro et al., 2001, Gasperini and Gibson, 1999, Gibson et al., 1999, Brand, 1997.6.30, Dobrovolskaia and Belitsky, 1997, Brand et al., 1994, Brand and Perrimon, 1993, Kaiser, 1993)
        Dras64B
        (Dobrovolskaia and Belitsky, 1997)
        RAS
        (Ashton-Beaucage and Therrien, 2007, Silver et al., 2003, Sternberg and Alberola-Ila, 1998)
        RAS2
        (Mirey et al., 2003)
        RAS64B
        (Sentürk et al., 2020, Park et al., 2013)
        Ras
        (Golovnin et al., 2015, Pastor-Pareja and Xu, 2013, Yamanaka et al., 2013, Gurskiy et al., 2012, Turski et al., 2012, Zhang and Therrien, 2008, Khoo et al., 2007, Yoneda et al., 2007, Caldwell et al., 2005, Jekely et al., 2005, Bilder, 2004, Pollock et al., 2004, Rebay, 2002, Baker, 2001, Foley and Sprenger, 2000, Potter et al., 2000, Montell, 1999)
        Ras2
        (Vega-Cuesta et al., 2020, Gurskiy et al., 2012, Yang and Terman, 2012, Bangi et al., 2011, Orme et al., 2006, Walker et al., 2006, Kramer et al., 2003, Santoni et al., 1998, Feng et al., 1995, Harrison et al., 1995, Lev et al., 1995, Harrison et al., 1994, Harrison et al., 1993, Lu et al., 1993, Salzberg et al., 1993, Fortini et al., 1992, Lev, 1992.7.8)
        Ras64B
        (Padash Barmchi et al., 2021, Nil et al., 2019, Rao and Deng, 2019.10.23, Strassburger et al., 2019, Jordán-Álvarez et al., 2017, Transgenic RNAi Project members, 2017-, Kuleesha et al., 2016, Xia et al., 2015, Bischof and FlyORF project members, 2014.6.20, Kwon et al., 2013, Park et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Miller et al., 2012, Morris et al., 2012, Munoz-Soriano et al., 2012, Diez et al., 2011, Franzdóttir et al., 2009, Curtis et al., 2007, Friedman and Perrimon, 2006)
        c-ras2
        (Cherbas and Cherbas, 1993)
        ras
        (Hariharan, 2005, Pollock et al., 2005, Ruiz-Gomez et al., 2005, Morey et al., 2003, Silver et al., 2003, Wolpert, 1994)
        ras-2
        (de Celis, 1997, Diaz-Benjumea and Hafen, 1994)
        ras2
        (Kopytova et al., 2016, Poels et al., 2004, Gasperini, 1999.8.27, Burke et al., 1998, Lightfoot et al., 1994, Yamamoto, 1994, Bishop and Corces, 1988, Cohen et al., 1988, Lev, 1988.3.28)
        Name Synonyms
        Ras oncogene at 64B
        (Cammarato et al., 2011)
        ras oncogene
        (Mozer, 1988.6.15)
        small GTP binding protein
        (Harrison, 1994.10.14)
        Secondary FlyBase IDs
        • FBgn0063029
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        References (148)