MCM8
mini-chromosome maintenance (MCM) family protein - facilitates repair synthesis during meiotic recombination
Please see the JBrowse view of Dmel\rec for information on other features
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Gene model reviewed during 5.45
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.47
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\rec using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signals
View Dmel\rec in GBrowse 23-58
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Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: rec CG4828
Source for merge of: rec CG14875
Annotations CG14875 and CG4828 merged as CG31293 in release 3 of the genome annotation.
Not allelic to c(3)G, since rec and c(3)G fully complement, also unlike c(3)G, rec has no discernible effect on the synaptonemal complex.
Recombination in homozygous females drastically reduced; total cross over between y and f in the X chromosome reduced from 56% to 2% with distal recombination being more severely affected than proximal. X nondisjunction increased from virtually 0 to 27%. In rec1/rec2, females show a similar reduction for ten regions between al and sp, where crossing over decreases to 9.1%, corresponding to 9% of normal. The number of progeny per homozygous female is reduced 75%; attributed to lethality of nondisjunctional products arising from distributive pairing between noncrossover heterologues. Phenotype of rec/+ is the same as wild-type; rec1 and rec2 homozygotes and hemizygotes have equivalent effects on recombination.