Gene model reviewed during 5.47
There is only one protein coding transcript and one polypeptide associated with this gene
Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Rh2 using the Feature Mapper tool.
Eye-enriched transcripts determined by ratio of expression level in wild-type heads. versus expression level in so heads.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Rh2 in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Rh2 CG16740
In a sample of 79 genes with multiple introns, 33 showed significant heterogeneity in G+C content among introns of the same gene and significant positive correspondence between the intron and the third codon position G+C content within genes. These results are consistent with selection adding against preferred codons at the start of genes.
ninaE and Rh2 chimeric constructs demonstrate multiple regions of the opsin protein are involved in regulating rhodopsin spectral specificity and the native and photoactivated forms of rhodopsin can be tuned independently of each other.
Transgenic flies expressing both Rh1 (ninaE) and Rh2 in photoreceptors R1-6 demonstrate a response that indicates that photoreceptors trigger receptor potentials tuned to combined spectral response of both rhodopsins.
The production of functional Rh2 protein requires ninaA.
The promoter region of Rh2 is a simple bipartite structure, the proximal region constitutes a functionally equivalent promoter core and the distal region determines cell-type specificity.
Analysis of the Rh2 promoter sequences using Ecol\lacZ and Ecol\CAT reporter gene constructs has shown that a promoter fragment extending from 183bp upstream of the transcription initiation site plus 32bp of the 5' untranslated leader is capable of conferring expression patterns characteristic of the endogenous Rh2 upon Ecol\CAT and Ecol\lacZ.
Encodes the opsin moiety of the rhodopsin specific to the ocelli. Not expressed in the eye nor is it expressed in Bolwig's organ, the larval photoreceptor (FBrf0048777). Rh2 under the control of the ninaE promoter in a ninaE background functions in R1-6 cells (FBrf0047647) but with different spectral characteristics and physiology (FBrf0048775). Rh2 encodes a 381-amino-acid protein that is 67% homologous to the opsin found in R1-6 encoded by ninaE, but only 35% homologous to Rh3 and Rh4 opsins.