FlyBase Gene Report: Dmel\rib

General Information

Symbol

Dmel\rib

Species

D. melanogaster

Name

ribbon

Annotation Symbol

CG7230

Feature Type

protein_coding_gene

FlyBase ID

FBgn0003254

Gene Model Status

Stock Availability

9 publicly available

Gene Summary

ribbon (rib) encodes a nuclear BTB-domain protein, expressed in most embryonic cells. It is required for development of the salivary gland and trachea, as well as for dorsal closure. It regulates both growth and differentiation of salivary gland cells. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Red Book
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

Sequence location

2R:19,270,078..19,281,396 [+]

Recombination map

2-88

RefSeq locus

NT_033778 REGION:19270078..19281396

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (23 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables DNA binding

inferred from electronic annotation with InterPro:IPR007889, InterPro:IPR009057

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

enables DNA-binding transcription factor activity

traceable author statement

(Sudarsan, 2003)

Biological Process (20 terms)

Terms Based on Experimental Evidence (14 terms)

CV Term

Evidence

References

involved_in central nervous system development

inferred from mutant phenotype

(Jack and Myette, 1997)

involved_in dorsal closure

inferred from mutant phenotype

(Blake et al., 1998)

involved_in epithelial cell migration, open tracheal system

inferred from mutant phenotype

(Bradley and Andrew, 2001, Shim et al., 2001)

involved_in establishment or maintenance of epithelial cell apical/basal polarity

inferred from mutant phenotype

(Kerman et al., 2008)

involved_in gonad development

inferred from mutant phenotype

(Weyers et al., 2011)

involved_in head involution

inferred from mutant phenotype

(Jack and Myette, 1997)

involved_in hindgut morphogenesis

inferred from mutant phenotype

(Blake et al., 1998, Jack and Myette, 1997)

involved_in Malpighian tubule morphogenesis

inferred from mutant phenotype

(Jack and Myette, 1997)

involved_in open tracheal system development

inferred from mutant phenotype

(Jack and Myette, 1997)

involved_in protein localization

inferred from mutant phenotype

(Blake et al., 1998)

involved_in regulation of cell shape

inferred from mutant phenotype

(Blake et al., 1998, Jack and Myette, 1997)

involved_in regulation of Malpighian tubule diameter

inferred from mutant phenotype

(Jack and Myette, 1997)

involved_in salivary gland morphogenesis

inferred from mutant phenotype

(Kerman et al., 2008, Blake et al., 1998, Jack and Myette, 1997)

involved_in tracheal outgrowth, open tracheal system

inferred from mutant phenotype

(Kerman et al., 2008)

Terms Based on Predictions or Assertions (9 terms)

CV Term

Evidence

References

involved_in cell migration

traceable author statement

(Abrams et al., 2003, Bradley et al., 2001)

involved_in cytoskeleton organization

traceable author statement

(Harden, 2002)

involved_in dorsal closure

traceable author statement

(Harden, 2002, Noselli and Agnes, 1999)

non-traceable author statement

(Abrams et al., 2003)

involved_in membrane organization

traceable author statement

(Sudarsan, 2003)

involved_in open tracheal system development

traceable author statement

(Sudarsan, 2003)

non-traceable author statement

(Abrams et al., 2003)

involved_in regulation of cell shape

traceable author statement

(Bradley et al., 2001)

involved_in regulation of transcription by RNA polymerase II

inferred from biological aspect of ancestor with PANTHER:PTN001135010

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in regulation of transcription, DNA-templated

traceable author statement

(Sudarsan, 2003)

involved_in salivary gland development

traceable author statement

(Abrams et al., 2003, Sudarsan, 2003)

Cellular Component (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in nucleus

inferred from direct assay

(Shim et al., 2001)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN001135010

(assigned by GO_Central )

(Gaudet et al., 2011)

located_in nucleus

traceable author statement

(Sudarsan, 2003)

Gene Group (FlyBase)

PIPSQUEAK TRANSCRIPTION FACTORS

Protein Family (UniProt)

-

Protein Signatures (InterPro)

Summaries

Gene Snapshot

ribbon (rib) encodes a nuclear BTB-domain protein, expressed in most embryonic cells. It is required for development of the salivary gland and trachea, as well as for dorsal closure. It regulates both growth and differentiation of salivary gland cells. [Date last reviewed: 2019-03-14]

Gene Group (FlyBase)

PIPSQUEAK TRANSCRIPTION FACTORS -: Pipsqueak transcription factors are sequence-specific DNA binding proteins that regulate transcription. These family members are characterized by a heix-turn-helix DNA-binding domain called Psq domain, which consists of four tandem repeats of a conserved 50-amino acid sequence, the Psq motif. (Adapted from FBrf0148954 and FBrf0105267).

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

rib: ribbon

Homozygous embryonic lethal; lateral extents of belts narrow; fusion of adjacent dentical bands in ventral midline; dorsal closure defective.

Summary (Interactive Fly)

BTB/POZ domain transcription factor - a regulator of epithelial morphogenesis that promotes cell migration - regulates morphogenesis of the embryonic salivary gland through transcriptional activation and repression

Interactive Fly

Gene Model and Products

Number of Transcripts

3

Number of Unique Polypeptides

2

Please see the JBrowse view of Dmel\rib for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Stop-codon suppression (UGA) postulated; FBrf0216884

Gene model reviewed during 5.44

Gene model reviewed during 5.50

A non-AUG start codon may be used for translation of one or more transcripts of this gene; based on the presence of conserved protein signatures within the 5' UTR without an in-frame AUG (FBrf0243886).

Sequence Ontology: Class of Gene

gene_with_stop_codon_read_through

(Jungreis et al., 2011)

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0086512

3956

661

FBtr0330057

4244

661

FBtr0330058

3956

680

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

FBpp0085700

71.0

661

6.61

FBpp0303090

71.0

661

6.61

FBpp0303091

73.1

680

6.46

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

661 aa isoforms: rib-PA, rib-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\rib using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

rib_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 4

epithelial cell

• condensed chromosome

(Lecuyer et al., 2007)

• condensed chromosome

(Lecuyer et al., 2007)

embryonic stage 4 -- 6

foregut anlage in statu nascendi

(Fisher et al., 2012)

hindgut anlage in statu nascendi

(Fisher et al., 2012)

posterior ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

embryonic stage 7 -- 8

(Fisher et al., 2012)

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

embryonic stage 9 -- 10

dorsal ectoderm

(Fisher et al., 2012)

foregut primordium

(Fisher et al., 2012)

inclusive hindgut primordium

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

(Fisher et al., 2012)

embryonic stage 11 -- 12

anterior midgut primordium

(Fisher et al., 2012)

cardiogenic mesoderm

(Fisher et al., 2012)

dorsal epidermis primordium

(Fisher et al., 2012)

foregut primordium

(Fisher et al., 2012)

hindgut proper primordium

(Fisher et al., 2012)

labral sensory complex primordium

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

somatic muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)

visceral muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)

(Fisher et al., 2012)

ventral epidermis primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

dorsal head epidermis

(Fisher et al., 2012)

embryonic dorsal epidermis

(Fisher et al., 2012)

embryonic epipharynx

(Fisher et al., 2012)

embryonic foregut

(Fisher et al., 2012)

embryonic ventral epidermis

(Fisher et al., 2012)

labral sensory complex

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in nucleus

inferred from direct assay

(Shim et al., 2001)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\rib in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\rib

View exonic expression by tissue for Dmel\rib

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0003254

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

44855/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0003254

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0003254

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0003254

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7230

Flygut - An atlas of the Drosophila adult midgut

FBgn0003254

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\rib

Stages(s) 4-6
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 10 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of rib

Transgenic constructs containing regulatory region of rib

Aberrations (Deficiencies and Duplications) ( 11 )

Inferred from experimentation ( 11 )

Gene disrupted in

(Christensen and Cook, 2007.10.29)

(Bradley and Andrew, 2001, Shim et al., 2001)

(Ryder, 2004.4.26)

(Bradley and Andrew, 2001, Shim et al., 2001, Blake et al., 1998)

(Shim et al., 2001)

Gene not disrupted in

(Bradley and Andrew, 2001)

Df(2R)EP2445^Δ1

(Bradley and Andrew, 2001)

Df(2R)EP2445^Δ2

(Bradley and Andrew, 2001)

(Bradley and Andrew, 2001)

(Blake et al., 1998)

(Shim et al., 2001)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal (with rib¹)

rib^P16

lethal (with rib²)

rib^P16

lethal (with rib^P16)

lethal (with rib^P34)

rib^P16

lethal | recessive

lethal - all die before end of pupal stage, with Scer\GAL4^pnr-MD237

rib^GD4486

lethal - all die during embryonic stage | recessive

rib^unspecified

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

rib^GD4486

viable, with Scer\GAL4^tin.CΔ4

rib^GD4486

Other Phenotypes

Allele

abnormal cell migration | embryonic stage (with rib^35.14)

rib^55.25

abnormal cell migration | embryonic stage (with rib^55.25)

rib^35.14

abnormal cell polarity (with rib¹)

rib^P7

abnormal cell polarity (with rib^P7)

rib¹

abnormal neuroanatomy | larval stage | recessive

rib^z1

some die during embryonic stage | recessive

rib^unspecified

some die during pupal stage, with Scer\GAL4^pnr-MD237

rib^GD4486

Phenotype manifest in

Allele

abdominal 1 lateral pentascolopidial chordotonal organ lch5

rib¹

abdominal 2 lateral pentascolopidial chordotonal organ lch5

rib¹

abdominal 3 lateral pentascolopidial chordotonal organ lch5

rib¹

abdominal 4 lateral pentascolopidial chordotonal organ lch5

rib¹

abdominal 5 lateral pentascolopidial chordotonal organ lch5

rib¹

abdominal 6 lateral pentascolopidial chordotonal organ lch5

rib¹

abdominal 7 lateral pentascolopidial chordotonal organ lch5

rib¹

denticle (with rib¹)

rib²

denticle (with rib²)

rib¹

denticle belt (with rib¹)

rib²

denticle belt (with rib²)

rib¹

rib¹

dorsal trunk primordium

dorsal trunk primordium (with rib¹)

rib^P7

dorsal trunk primordium (with rib^P7)

rib¹

embryo | dorsal

rib^unspecified

embryo | dorsal closure stage

rib¹

embryonic/first instar larval cuticle

rib²

embryonic/first instar larval cuticle (with rib¹)

rib²

embryonic/first instar larval cuticle (with rib²)

rib¹

embryonic/first instar larval cuticle | dorsal

rib²

embryonic/first instar larval cuticle | dorsal (with rib¹)

rib²

embryonic/first instar larval cuticle | dorsal (with rib²)

rib¹

embryonic/larval dorsal branch

rib¹

embryonic/larval dorsal trunk

rib¹

embryonic/larval ganglionic branch

rib¹

embryonic/larval hindgut | embryonic stage

embryonic/larval lateral trunk

rib¹

embryonic/larval midgut | embryonic stage

embryonic/larval salivary gland

rib¹

embryonic/larval salivary gland | embryonic stage

embryonic/larval salivary gland common duct | embryonic stage

rib¹

embryonic/larval salivary gland duct

rib¹

embryonic/larval salivary gland duct | embryonic stage

rib¹

embryonic/larval tracheal system

rib¹

embryonic epidermis

rib¹

embryonic epidermis | dorsal

rib¹

rib^z1

embryonic midgut constriction

rib¹

germline cell | embryonic stage (with rib¹)

germline cell | embryonic stage (with rib^35.14)

germline cell | embryonic stage (with rib^55.25)

gonad | embryonic stage (with rib¹)

gonad | embryonic stage (with rib^6.24)

rib^55.25

gonad | embryonic stage (with rib^35.14)

gonad | embryonic stage (with rib^55.25)

gonadal sheath proper primordium (with rib¹)

gonadal sheath proper primordium (with rib^35.14)

gonadal sheath proper primordium (with rib^55.25)

gonadal sheath proper primordium | embryonic stage (with rib^6.24)

rib^55.25

gonadal sheath proper primordium | embryonic stage (with rib^55.25)

rib^6.24

rib¹

Malpighian tubule

rib¹

peripheral nervous system precursor cluster

rib¹

presumptive embryonic/larval central nervous system

presumptive embryonic/larval peripheral nervous system

presumptive embryonic/larval tracheal system

presumptive embryonic/larval tracheal system (with Df(2R)rib-ex12)

presumptive embryonic salivary gland

presumptive embryonic salivary gland (with rib¹)

rib^P7

presumptive embryonic salivary gland (with rib^P7)

rib¹

rib¹

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (3)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

2 of 15

Yes

No

1 of 15

No

Yes

1 of 15

No

No

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

1 of 15

Yes

Yes

Rattus norvegicus (Norway rat) (1)

1 of 13

Yes

No

Xenopus tropicalis (Western clawed frog) (1)

1 of 12

Yes

Yes

Danio rerio (Zebrafish) (1)

1 of 15

Yes

Yes

Caenorhabditis elegans (Nematode, roundworm) (1)

1 of 15

Yes

Yes

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091904UC )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Dsuz\DS10_00005834

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Drosophila persimilis

Drosophila willistoni

Drosophila virilis

Drosophila mojavensis

Drosophila grimshawi

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091505XR )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Glossina morsitans

Tsetse fly

Gmor\GMOY009099

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_09338

Mayetiola destructor

Hessian fly

Mdes\Mdes007905

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL006690

Anopheles darlingi

American malaria mosquito

Adar\ADAC000442

Anopheles gambiae

Malaria mosquito

Agam\AGAP011902

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ010694

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W05X0 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA012231

Bombyx mori

Silkmoth

Bmor\BGIBMGA001210

Danaus plexippus

Monarch butterfly

Dple\DPOGS215980-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL008679

Heliconius melpomene

Postman butterfly

Hmel\HMEL004821

Apis florea

Little honeybee

Aflo\4916778884

Apis mellifera

Western honey bee

Bombus impatiens

Common eastern bumble bee

Bombus terrestris

Buff-tailed bumblebee

Linepithema humile

Argentine ant

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:001bbb

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG009116

Dendroctonus ponderosae

Mountain pine beetle

Tribolium castaneum

Red flour beetle

Tcas\GLEAN_07162

Pediculus humanus

Human body louse

Phum\PHUM088440

Pediculus humanus

Human body louse

Phum\PHUM088430

Rhodnius prolixus

Kissing bug

Rpro\RPRC007714

Cimex lectularius

Bed bug

Clec\CLEC007268

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI004381

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_14151

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( None identified )

No non-Insect Arthropod orthologies identified

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )

No non-Arthropod Metazoa orthologies identified

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (24)

Gene Symbol

Score

Source

Alignment

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

(Silva et al., 2016)

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2011)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Rhee et al., 2014)

pull down, tag visualisation

(Cheng et al., 2013)

(Silva et al., 2016)

experimental knowledge based

(Guruharsha et al., 2011)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Kerman et al., 2008)

enhanceable

(Silva et al., 2016)

suppressible

(Kerman et al., 2008)

suppressible

(Blake et al., 1999)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Silva et al., 2016)

enhanceable

(Kerman et al., 2008)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

69332

DroID - A comprehensive database of gene and protein interactions.

FBgn0003254

MIST (genetic) - An integrated Molecular Interaction Database

rib

MIST (protein-protein) - An integrated Molecular Interaction Database

rib

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

2R

Recombination map

2-88

Cytogenetic map

Sequence location

2R:19,270,078..19,281,396 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

56C6-56C6

Limits computationally determined from genome sequence between P{PZ}ena⁰²⁰²⁹&P{lacW}cora^k08713 and P{lacW}hts^k06121

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-88

(FlyBase, 2016, Tearle and Nusslein-Volhard, 1987)

2-94.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

cora

(Shim et al., 2001)

Notes

Stocks and Reagents

Stocks (9)

7095

w¹¹¹⁸; P{UAS-rib.B}HVII

50682

y¹ v¹; P{TRiP.HMC03083}attP2

92321

y¹ w^*; PBac{rib-GFP.FPTB}VK00037

7090

cn¹ rib² bw¹/CyO, P{ftz-lacB}E3

3240

cn¹ rib¹ bw¹ speck¹/CyO

106935

cn¹ rib¹ bw¹ speck¹/CyO

v103977

P{KK103571}VIE-260B

v15900

w¹¹¹⁸ P{GD4486}v15900

v318886

PBac{fTRG00340.sfGFP-TVPTBF}VK00033

Genomic Clones (19)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (261)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD16058

Other clones

DPiM_LD16058

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0003254

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0003254

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

44855

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Source for merge of: CG7230 rib

(Bradley and Andrew, 2001)

Additional comments

Other Comments

rib is required for specific tracheal branch migration.

(Bradley and Andrew, 2001)

Mutations in rib disrupt the coupling of movement of the cell bodies and apical and basal surfaces of the tracheal epithelium that is normally seen during tracheal system development; in rib mutants the basal surface continues to extend towards its normal targets, but movement and morphogenesis of the tracheal cell boies and apical surface is severely impaired.

(Shim et al., 2001)

rib is required for the proper shape of tubular epithelial tissues in Drosophila.

(Jack and Myette, 1997)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 45 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

44855

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0003254

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0003254

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

44855/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0003254

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

rib_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0003254

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0003254

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7230

Flygut - An atlas of the Drosophila adult midgut

FBgn0003254

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

44855

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG7230

MARRVEL_MODEL - MARRVEL (model organism gene)

44855

modMine - A data warehouse for the modENCODE project

FBgn0003254

Linkouts

BioGRID - A database of protein and genetic interactions.

69332

DroID - A comprehensive database of gene and protein interactions.

FBgn0003254

DRSC - Results frm RNAi screens

FBgn0003254

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0003254

FlyMine - An integrated database for Drosophila genomics

FBgn0003254

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (genetic) - An integrated Molecular Interaction Database

rib

MIST (protein-protein) - An integrated Molecular Interaction Database

rib

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

CG7230

(Schertel et al., 2013, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Haussmann et al., 2008, Brody et al., 2002, Siegmund and Lehmann, 2002, Shim et al., 2001)

RIB

(Cheng et al., 2013, Bajpe et al., 2008)

Rib

(Loganathan et al., 2021, Chaharbakhshi and Jemc, 2016)

fus1

(Weyers et al., 2011)

gene 5

(Bradley and Andrew, 2001)

Name Synonyms

SGP cluster fusion defects 1

(Weyers et al., 2011)

ribbon

(Cohen et al., 2020, Wieschaus and Nüsslein-Volhard, 2016, Humphreys et al., 2013, Weyers et al., 2011, Biehs et al., 2010, Bates et al., 2008, Cheshire et al., 2008, Kerman et al., 2008, Kerman et al., 2007)

Secondary FlyBase IDs

FBgn0034424

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (109)

Report Sections