DLGR2, lgr2, DLGR-2, BG:DS00180.13
G-protein coupled receptor expressed in the CNS and muscle - required for wing expansion, cuticle hardening and melanization
Please see the JBrowse view of Dmel\rk for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.52
5.5 (northern blot)
There is only one protein coding transcript and one polypeptide associated with this gene
1360 (aa)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\rk using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
rk transcripts are detected in pupae and in embryos, but not in larvae or adults.
JBrowse - Visual display of RNA-Seq signals
View Dmel\rk in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
rk is necessary for the death and resorption of wing blade cells after eclosion.
Strong alleles have legs, especially metathoracic ones, flattened and bent. Femora and tibiae bowed in middle; first two tarsal joints shortened, bent and flattened; last three tarsal joints almost fused. Wings unexpanded, resembling those of pu. Posterior scutellar bristles erect and crossed. Viability may be reduced. Weak alleles do not show the leg phenotype, or they overlap wild type; may have partially expanded wings and normal posterior scutellar bristles. Even strong alleles more extreme when hemizygous with rk deficiencies.
Source for identity of glycoprotein-hormone-receptor-II CG8930 was sequence comparison ( date:000504 ).
Source for identity of: rk CG8930
Source for identity of: glycoprotein-hormone-receptor-II CG8930