transcription factor - homeodomain - plays a critical role in restriction of the number of photoreceptor precursors in the specification of R8 photoreceptors - a bistable loop between and locks in R8 fate
Gene model reviewed during 5.48
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ro using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\ro in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
The R8 fate in the developing eye is likely to be decided by the balance of the transcription factors encoded by ato and ro. The ato and ro products act as positive and negative factors, respectively, of such R8-specific genes as boss.
A 5.8kb genomic fragment contains all the information required for normal ro expression and function. Important cis-regulatory sequences are located both in the 5' promoter region (between -940 and -340, coordinates from FBrf0047664) and a tissue-specific enhancer is located in the first intron. Amino acids located in the C-terminal region of the homeodomain play an important role in binding site recognition.
ro and gl gene products are required for B and B-H2 gene expression in R1 and R6.
Expression of ro in the presumptive R7 cell transforms the cell into an R1-6 type photoreceptor. The transformation is cell autonomous and depends on the presence of the sev gene. In wild type, ro may function autonomously in the specification of R2/5 photoreceptor identity but by itself may not initiate neural development.
Adult eyes are rough with irregular facet size and shape. Ommatidia irregular size and shape. The abnormal ro phenotype is due to a developmental defect: pattern formation defect.
Analysis of somatic mosaics suggests that the or gene function is required only in photoreceptors R2 and R5.