FlyBase Gene Report: Dmel\rod

General Information

Symbol

Dmel\rod

Species

D. melanogaster

Name

rough deal

Annotation Symbol

CG1569

Feature Type

protein_coding_gene

FlyBase ID

FBgn0003268

Gene Model Status

Current

Stock Availability

3 publicly available

Gene Summary

rough deal (rod) encodes the major subunit of the Rod-Zw10-Zwilch (RZZ) complex. RZZ is an essential component of the outer kinetochore during mitosis. RZZ helps monitor and correct kinetochore-microtubule attachments during prometaphase, and consequently it regulates mitotic progression. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Red Book
Interactive Fly

Also Known As

EP3408

Key Links

Genomic Location

Cytogenetic map

100C6-100C7

Sequence location

3R:31,580,951..31,588,244 [+]

Recombination map

3-102

RefSeq locus

NT_033777 REGION:31580951..31588244

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (17 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables protein binding

inferred from physical interaction with FLYBASE:Zw10; FB:FBgn0004643, FLYBASE:Zwilch; FB:FBgn0061476

(Williams et al., 2003)

enables small GTPase binding

inferred from physical interaction with FLYBASE:Rab18; FB:FBgn0015794

(Gillingham et al., 2014)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables small GTPase binding

inferred from biological aspect of ancestor with PANTHER:PTN001038564

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (7 terms)

Terms Based on Experimental Evidence (6 terms)

CV Term

Evidence

References

involved_in Golgi organization

inferred from mutant phenotype

(Wainman et al., 2012)

involved_in mitotic sister chromatid segregation

inferred from mutant phenotype

(Scaerou et al., 2001)

involved_in mitotic spindle assembly checkpoint signaling

inferred from mutant phenotype

(Basto et al., 2000)

involved_in protein localization to kinetochore

inferred from mutant phenotype

(Dzhindzhev et al., 2005)

involved_in regulation of chromosome separation

inferred from mutant phenotype

(Clemente-Ruiz et al., 2016)

involved_in regulation of mitotic metaphase/anaphase transition

inferred from mutant phenotype

(Défachelles et al., 2015)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in mitotic sister chromatid segregation

inferred from biological aspect of ancestor with PANTHER:PTN001038564

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in mitotic spindle assembly checkpoint signaling

inferred from biological aspect of ancestor with PANTHER:PTN001038564

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in protein localization to kinetochore involved in kinetochore assembly

inferred from biological aspect of ancestor with PANTHER:PTN001038564

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (8 terms)

Terms Based on Experimental Evidence (8 terms)

CV Term

Evidence

References

located_in acroblast

inferred from direct assay

(Wainman et al., 2012)

located_in cytoplasm

inferred from direct assay

(Buffin et al., 2005)

located_in Golgi stack

inferred from direct assay

(Wainman et al., 2012)

located_in kinetochore microtubule

inferred from direct assay

(Wainman et al., 2012, Buffin et al., 2005, Basto et al., 2004, Scaerou et al., 2001, Scaerou et al., 1999)

located_in kinetochore

inferred from direct assay

(Wainman et al., 2012, Griffis et al., 2007, Buffin et al., 2005, Basto et al., 2004, Scaerou et al., 2001, Scaerou et al., 1999)

part_of RZZ complex

inferred from direct assay

(Williams et al., 2003)

inferred from physical interaction with FLYBASE:Zw10; FB:FBgn0004643, FLYBASE:Zwilch; FB:FBgn0061476

(Défachelles et al., 2015)

located_in spindle midzone

inferred from direct assay

(Wainman et al., 2012)

located_in spindle

inferred from direct assay

(Griffis et al., 2007)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN001038564

(assigned by GO_Central )

(Gaudet et al., 2011)

is_active_in kinetochore microtubule

inferred from biological aspect of ancestor with PANTHER:PTN001038564

(assigned by GO_Central )

(Gaudet et al., 2011)

part_of RZZ complex

inferred from biological aspect of ancestor with PANTHER:PTN001038564

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

RZZ COMPLEX

Protein Family (UniProt)

Protein Signatures (InterPro)

RZZ complex, subunit KNTC1/ROD, C-terminal

Summaries

Gene Snapshot

Gene Group (FlyBase)

RZZ COMPLEX -: The RZZ (Rod, Zwilch and Zw10) complex is a kinetochore component that plays an essential role in spindle assembly checkpoint, blocking the metaphase-to-anaphase transition until all chromosomes properly aligned in a metaphase plate. In mammalian cells, the RZZ complex has a fourth component, Zwint-1. (Adapted from FBrf0219791).

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

rod: rough deal

Mutants show mitotic abnormalities in larval neuroblasts; there is a high frequency of both aneuploid cells and abnormal anaphase figures, with lagging chromatids, anaphase bridges, and stretched chromatid arms. Abnormal chromosome behavior also occurs in the second meiotic anaphase in male meiosis, although motile sperm are produced. All surviving homozygous females and 90% of surviving homozygous males are sterile and have roughened eyes, sparse abdominal bristles, and notched wings.

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\rod for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure New Section

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9V9W7)

If you don't see the viewer to the right, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Gene model reviewed during 5.53

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.55

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

rod-RA

FBtr0085795

NM_057357

6479

2089

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

rod-PA

FBpp0085156

239.7

2089

6.07

NP_476705

AAF57162

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

2098 (aa); 200 (kD observed); 240 (kD predicted)

(Scaerou et al., 1999)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

RZZ complex, subunit KNTC1/ROD, C-terminal

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\rod using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

rod_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage

embryonic/larval brain

(Scaerou et al., 1999)

third instar larval stage

neuroblast of embryonic/larval brain

(Scaerou et al., 1999)

spermatogenesis & adult stage

spermatocyte

(Scaerou et al., 1999)

Additional Descriptive Data

A 200 kD rod protein is detected in western blots of extracts of Schneider L2 tissue culture cells and of larval brains. rod protein localizes in similar dynamic patterns in meiotic spermatocytes and in mitotic neuroblasts from third larval instar brains. The protein localizes to kinetochores at prometaphase, is found in kinetochores and kinetochore microtubule fibers at metaphase, and once again localizes to kinetochores at anaphase.

(Scaerou et al., 1999)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in acroblast

inferred from direct assay

(Wainman et al., 2012)

located_in cytoplasm

inferred from direct assay

(Buffin et al., 2005)

located_in Golgi stack

inferred from direct assay

(Wainman et al., 2012)

located_in kinetochore microtubule

inferred from direct assay

(Wainman et al., 2012, Buffin et al., 2005, Basto et al., 2004, Scaerou et al., 2001, Scaerou et al., 1999)

located_in kinetochore

inferred from direct assay

(Wainman et al., 2012, Griffis et al., 2007, Buffin et al., 2005, Basto et al., 2004, Scaerou et al., 2001, Scaerou et al., 1999)

part_of RZZ complex

inferred from direct assay

(Williams et al., 2003)

inferred from physical interaction with FLYBASE:Zw10; FB:FBgn0004643, FLYBASE:Zwilch; FB:FBgn0061476

(Défachelles et al., 2015)

located_in spindle midzone

inferred from direct assay

(Wainman et al., 2012)

located_in spindle

inferred from direct assay

(Griffis et al., 2007)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\rod in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\rod

View exonic expression by tissue for Dmel\rod

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43719/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0003268

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0003268

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0003268

Flygut - An atlas of the Drosophila adult midgut

FBgn0003268

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 17 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 22 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of rod

Transgenic constructs containing regulatory region of rod

Aberrations (Deficiencies and Duplications) ( 6 )

Inferred from experimentation ( 6 )

Gene disrupted in

Df(3R)A113

(Schejter and Wieschaus, 1993)

Df(3R)E(sina)9

(Wisotzkey et al., 1998)

Df(3R)P4.1

(Scaerou et al., 1999)

Gene not disrupted in

Df(3R)E40

(Wisotzkey et al., 1998)

Df(3R)Kpn-A

(Wisotzkey et al., 1998)

Gene duplicated in

Dp(3;1)48

(Schejter and Wieschaus, 1993)

Inferred from location ( 0 )

Dp(3;2)GV-CH321-70F21

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | recessive

rod^X-1

lethal - all die before end of larval stage | recessive

rod^H4.8

lethal - all die during embryonic stage | maternal effect

rod^Z3

partially lethal

partially lethal - majority live

rod^X-2

viable

rod^EY04576

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

rod^GD8768

viable, with Scer\GAL4^Mef2.PR

rod^GD8768

viable, with Scer\GAL4^pnr-MD237

rod^GD8768

viable, with Scer\GAL4^tin.CΔ4

rod^GD8768

Sterility

Allele

fertile

rod^EY04576

Other Phenotypes

Allele

abnormal mitotic cell cycle

abnormal mitotic cell cycle | embryonic stage 4 | maternal effect | drug conditional

rod^Z3

abnormal mitotic cell cycle | maternal effect

rod^Z3

abnormal neuroanatomy | dominant | third instar larval stage

rod^Z3

abnormal neuroanatomy | third instar larval stage

abnormal neuroanatomy | third instar larval stage | drug conditional

rod^unspecified

some die during larval stage | recessive

rod^H4.8

visible, with Scer\GAL4^ey.PH

rod^EP3408

visible, with Scer\GAL4^pnr-MD237

rod^GD8768

wild-type

rod^+tC3L9

Phenotype manifest in

Allele

acroblast

rod¹¹⁰⁰

chromatin & mitotic anaphase

rod^H4.8

chromatin & mitotic telophase

rod^H4.8

embryonic/larval brain | third instar larval stage

rod^Z3

embryonic/larval brain | third instar larval stage | drug conditional

rod^unspecified

eye, with Scer\GAL4^ey.PH

rod^EP3408

Golgi stack

rod¹¹⁰⁰

kinetochore | third instar larval stage

larval intersegmental nerve, with Scer\GAL4^elav-C155

rod^EP3408

larval neuroblast | third instar larval stage

meiotic cell cycle

rod¹¹⁰⁰

mitotic anaphase

neuroblast

rod^X-1

nuclear chromosome

nuclear chromosome & mitotic anaphase

rod^H4.8

nuclear chromosome | embryonic stage

rod^Z3

nucleus | embryonic stage

rod^Z3

polar body nucleus | embryonic stage

rod^Z3

polar body nucleus | embryonic stage 4 | drug conditional

rod^Z3

spermatocyte

rod¹¹⁰⁰

trichogen cell, with Scer\GAL4^pnr-MD237

rod^GD8768

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\KNTC1

12 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Kntc1

11 of 15

Yes

Rattus norvegicus (Norway rat) (2)

Rnor\Kntc1

9 of 13

Yes

Rnor\LOC103693647

2 of 13

Yes

Xenopus tropicalis (Western clawed frog) (1)

Xtro\kntc1

7 of 12

Yes

Danio rerio (Zebrafish) (1)

Drer\kntc1

8 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\rod-1

8 of 15

Yes

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Other Organism Orthologs (via OrthoDB)

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (0)

No records found.

Human Disease Associations

FlyBase Human Disease Model Reports

cancer, models of chromosomal instability

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

rod^GD8768

model of cancer

CEA with BacA\p35^UAS.cHa

(Muzzopappa et al., 2017)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

rod^unspecified

ameliorates primary autosomal recessive microcephaly 5

modeled by asp^E3

(Buffin et al., 2007)

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

KNTC1; kinetochore associated 1

12 of 15

607363

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

rod - DCTN1-p150

anti tag coimmunoprecipitation, western blot

(Basto et al., 2004)

rod - DCTN2-p50

anti tag coimmunoprecipitation, western blot

(Basto et al., 2004)

rod - Dhc64C

anti tag coimmunoprecipitation, western blot

(Basto et al., 2004)

rod - Mad1

anti tag coimmunoprecipitation, western blot, peptide massfingerprinting

(Défachelles et al., 2015)

rod - Mis12

anti tag coimmunoprecipitation, peptide massfingerprinting

(Przewloka et al., 2007)

rod - Nnf1a

anti tag coimmunoprecipitation, peptide massfingerprinting

(Przewloka et al., 2007)

rod - Rab18

pull down, peptide massfingerprinting, anti tag western blot

(Gillingham et al., 2014, Gillingham et al., 2014)

rod - Zw10

anti tag coimmunoprecipitation, peptide massfingerprinting, comigration in non denaturing gel electrophoresis, molecular weight estimation by staining, western blot, anti bait coimmunoprecipitation, molecular sieving

(Menant and Karess, 2020, Défachelles et al., 2015, D'Avino et al., 2009, Chen et al., 2007, Williams et al., 2003, Scaerou et al., 2001)

rod - Zwilch

comigration in non denaturing gel electrophoresis, molecular weight estimation by staining, anti bait coimmunoprecipitation, peptide massfingerprinting, anti tag coimmunoprecipitation, western blot

(Menant and Karess, 2020, Défachelles et al., 2015, Williams et al., 2003)

rod - sstn

anti tag coimmunoprecipitation, peptide massfingerprinting

(Liu et al., 2015)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

rod

suppressible

CycB

(Défachelles et al., 2015)

rod

suppressible

shtd

(Défachelles et al., 2015)

rod

suppressible

(Muzzopappa et al., 2017)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

asp

suppressible

rod

(Basto et al., 2000)

enhanceable

rod

(Singh et al., 2005)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0003268

MIST (protein-protein) - An integrated Molecular Interaction Database

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-102

Cytogenetic map

100C6-100C7

Sequence location

3R:31,580,951..31,588,244 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

100C6-100C7

Limits computationally determined from genome sequence between P{EP}pygo^EP1076 and P{PZ}ttk⁰²⁶⁶⁷&P{lacW}ttk^j6C7

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

100C5-100C5

(Aguliera, 1998.12.16)

100C-100D

(determined by in situ hybridisation)

(Karess and Glover, 1989)

Experimentally Determined Recombination Data

Location

3-102

(FlyBase, 2016)

3-99.1

(Comeron et al., 2012)

3-105.1

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (3)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

19842

y¹ w^67c23; P{EPgy2}rod^EY04576

29721

w^*; P{rod^+tC3L9}2/CyO; rod^X-1/TM6B, Tb¹

VDRC

v19152

w¹¹¹⁸; P{GD8768}v19152

Genomic Clones (20)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (16)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0003268

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

43719

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Scaerou et al., 1999)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: rod CG1569

(Zhao, 1999.11)

Source for database merge of

Source for merge of: rod EP3408

(FlyBase, 1996-)

Additional comments

FlyBase curator comment: "EP3408" overexpression phenotype stated to be due to its effect on pygo but orientation of the P{EP} element suggests otherwise.

(Singh et al., 2005)

Source for merge of rod EP3408 was that EP3408 insertion is within rod (and in the right orientation) ( date:040519 ).

(FlyBase, 1996-)

Other Comments

dsRNA has been synthesised against this gene and transfected into S2 cells.

(Griffis et al., 2007)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Mutations in rod result in mitotic segregational failure due to delayed or incomplete release of sister chromatids.

(Karess et al., 1990)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 32 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

43719

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9V9W7

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9V9W7

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43719/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0003268

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

rod_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0003268

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0003268

Flygut - An atlas of the Drosophila adult midgut

FBgn0003268

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

43719

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC034281

InterPro - A database of protein families, domains and functional sites

RZZ complex, subunit KNTC1/ROD, C-terminal

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG1569

MARRVEL_MODEL - MARRVEL (model organism gene)

43719

modMine - A data warehouse for the modENCODE project

FBgn0003268

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0003268

DRSC - Results frm RNAi screens

FBgn0003268

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0003268

FlyMine - An integrated database for Drosophila genomics

FBgn0003268

MIST (protein-protein) - An integrated Molecular Interaction Database

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

CG1569

(Çiçek et al., 2016, Howell et al., 2012, Przewloka et al., 2007, Buffin, 2005, Buffin et al., 2005, Pile et al., 2003)

EP3408

(Singh et al., 2005)

ROD

(Radford et al., 2015, Olszak et al., 2011, Torras-Llort et al., 2010, Godinho and Tavares, 2008, Blower et al., 2006, Heun et al., 2006, Erhardt et al., 2005, Parry et al., 2003, Williams et al., 2003)

Rod1

(Rosa-Ferreira et al., 2018)

pNB20A

(Scaerou et al., 1999)

Name Synonyms

Rough Deal

(Emre et al., 2011)

Rough deal

(Dzhindzhev et al., 2005)

rough deal

(Défachelles et al., 2015, Howell et al., 2012, Castellanos et al., 2008, Parker et al., 2008, Aguliera, 1998.12.16)

roughdeal

(Kuang et al., 2014)

Secondary FlyBase IDs

FBgn0044458

Datasets (8)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (8)

Result

Result Type

Title

scRNAseq_2020_Cattenoz_NI_seq_clustering

cell clustering analysis

Clustering analysis of hemocytes from non-infested third instar larvae

scRNAseq_2020_Cattenoz_WI_seq_clustering

cell clustering analysis

Clustering analysis of hemocytes from wasp-infested third instar larvae

scRNAseq_2020_Cho_NI72LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from non-infested larvae at 72 h after egg-laying

scRNAseq_2020_Cho_NI96LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from non-infested larvae at 96 h after egg-laying

scRNAseq_2020_Cho_NI120LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from non-infested larvae at 120 h after egg-laying

scRNAseq_2020_Cho_WI96LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from wasp-infested larvae at 96 h after egg-laying

scRNAseq_2020_Cho_NI96HL_seq_clustering

cell clustering analysis

Clustering analysis of circulating hemocytes from non-infested larvae at 96 h after egg-laying

scRNAseq_2020_Cho_NI120HL_seq_clustering

cell clustering analysis

Clustering analysis of circulating hemocytes from non-infested larvae at 120 h after egg-laying

References (134)

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