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Gene Dmel\amos

General Information
Symbol	Dmel\amos	Species	D. melanogaster
Name	absent MD neurons and olfactory sensilla	Annotation symbol	CG10393
Feature type	protein_coding_gene	FlyBase ID	FBgn0003270
Gene Model Status	Current	Stock availability	141 publicly available
Also Known As	Tft, Roi
Genomic Location
Chromosome (arm)	2L	Recombination map	2-53.6
Cytogenetic map	36F6-36F6	Sequence location	2L:18,596,047..18,597,200 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene absent MD neurons and olfactory sensilla is referred to in FlyBase by the symbol Dmel\amos (CG10393, FBgn0003270). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein heterodimerization activity; RNA polymerase II regulatory region DNA binding. There is experimental evidence that it is involved in the biological process: sensory organ boundary specification; sensory organ precursor cell fate determination; sensory organ development. 16 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; adult segment; external compound sense organ; peripheral nervous system; antennal segment; adult mesothoracic segment; nervous system; imaginal precursor; abdominal dorsal bipolar neuron dbp; eo support cell; rhabdomere R7; rhabdomere; dorsal thoracic disc. It has one annotated transcript and one annotated polypeptide. Protein features are: Helix-loop-helix DNA-binding. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of no expression detected. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: No expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1636062_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of amos. Gene sequence location is 2L:18596047..18597200.
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	Roi: Rough eye Eye facets of Roi/+ irregularly rounded, sometimes enlarged; eyes sometimes bulge. Roi/Roi lethal; Roi/S viable. Acts as a partial suppressor of B (E. H. Grell). Viability good. RK2A. Tft: Tufted Dominant mutation characterized by an increased number of bristles in the postalar, dorsocentral, and scutellar regions; tufts of bristles formed on mesothorax in both homo- and heterozygotes; bristles shorter in homozygotes. Extra bristles located dorsal to halteres at junction of thorax and abdomen. Posterior part of mesonotum appears wider than normal. Homo- and heterozygous females have a greatly reduced scutellum; scutoscutellar suture almost absent; heterozygous males have a nearly normal scutellum (Arnheim, 1967). Small to moderate amounts of fluid tend to remain between the epithelial layers of the wing. Penetrance of extra-bristle character 100%. Tft not suppressed by Df(1)sc19 = Df(1)1A1;1B4-5 but suppressed by Df(1)260-1 = Df(1)1A1;1B4-6 (Garcia-Bellido, communicated to Campuzano, Carramolino, Cabrera, Ruiz-Gomez, Villares, Boronat, and Modolell, 1985, Cell 40: 327-38). Cell autonomous in mosaics (Arnheim, 1967). Viability and fertility low.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Sequence features BKN25611 HFA03484 Controlled Vocabulary Terms protein heterodimerization activity RNA polymerase II regulatory region DNA binding
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 36F6-36F6   Limits computationally determined from genome sequence between P{lacW}Aac11k06710 and P{EP}CG10413EP2164
Experimentally Determined Cytological Location
Cytogenetic map Notes References 36F2-36F6   (determined by in situ hybridisation)   (Goulding et al., 2000) 36E-36F     (Huang et al., 2000) 36F-36F     (Goulding, 1999.7.7)
Experimentally Determined Recombination Data
Location	2-53.6 (Tokunaga, 1967) 2-52.5 (Chanut et al., 2002)
Left of (cM)	pr (Chanut et al., 2002) Bl (Tokunaga, 1967)
Right of (cM)	b (Chanut et al., 2002)
Notes	Left arm of chromosome 2; not separated from In(2L)t.
Gene Model & Products
Please see the GBrowse view of Dmel\amos for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) amos-RA FBtr0081081  NM_058098   1154   198
Additional Transcript Data & Comments
Reported size (kB)	0.8 (northern blot) (Goulding et al., 2000)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein amos-PA   FBpp0080631   22.6   198   5.68     NP_477446   AAF53678
Additional Polypeptide Data & Comments
Reported size (kDa)	198 (aa) (Huang et al., 2000, Goulding et al., 2000)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Helix-loop-helix DNA-binding (IPR011598)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014134 AAF53678   AC007137   AF166113 AAD45410   BT028832   BT028865
UniProtKB/Swiss-Prot	Q9Y0A7
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   embryonic antennal segment | restricted   (Huang et al., 2000) embryonic mandibular segment   (Goulding et al., 2000) antenno-maxillary complex | restricted   (Huang et al., 2000) embryonic labial segment | restricted   (Huang et al., 2000) embryonic antennal segment   (Goulding et al., 2000) embryonic labial segment   (Goulding et al., 2000) abdominal segment | restricted   (Huang et al., 2000) sensory mother cell   (Huang et al., 2000) thoracic segment | restricted   (Huang et al., 2000) antenno-maxillary complex | precursor   (Goulding et al., 2000) olfactory sensory organ | precursor   (Goulding et al., 2000) blastoderm stage   organism | ubiquitous   (Huang et al., 2000) embryonic stage 5     (Goulding et al., 2000) embryonic stage 10   abdominal segment | restricted   (Goulding et al., 2000) thoracic segment | restricted   (Goulding et al., 2000) pupal stage   antennal disc   (Goulding et al., 2000) olfactory sensory organ | precursor   (Goulding et al., 2000) adult stage & oogenesis   centripetally migrating follicle cell   (Goulding et al., 2000) nurse cell   (Goulding et al., 2000) oocyte   (Goulding et al., 2000)
Additional Descriptive Data
	amos transcripts are expressed transiently and dynamically during embryogenesis. They are present in a small cluster of ectodermal cells in each thoracic and abdominal segment during stage 10. In stage 11, expression is restricted to a single cell in each segment which quickly ceases expression of amos, first in the thorax and then in the abdomen. The restriction of amos expression to a single cell involves lateral inhibition and does not occur in N mutants. amos expression is also observed in developing head segments in the antennal, mandibular, and labial segments in regions corresponding to the anlage for the olfactory sense organs and the larval antennomaxillary complex. amos transcripts are also detected in cellular blastoderm embryos in a dorsoventral band in the posterior of the embryo and during oogenesis in nurse cells, centripetally migrating follicle cells, and in the oocyte. Later in development, amos transcripts are detected at 0-4hr APF in the anlage of the tarsal claw. The main site of later expression is in the antennal disc, initiating at puparium formation. Expression occurs in three semicircular bands on the medial side of the developing third segment. These are sites from which olfactory sensillum precursors are selected. (Goulding et al., 2000) amos transcripts are ubiquitous before cellularization. The first zygotic expression is detected in clusters of cells in the procephalic region followed by expression in the segments of the head, thorax, and abdomen. Expression is observed in one cluster in each thoracic and abdominal hemisegment and in three clusters in the maxillary and labial hemisegments and in the procephalic region. With time, expression becomes limited within each cluster. (Huang et al., 2000)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0003270    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0003270 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of no expression detected. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0003270 expression level Developmental Stage   Expression Level embryo 00-02hr    629 embryo 02-04hr    1985 embryo 04-06hr    267 embryo 06-08hr    167 embryo 08-10hr    88 embryo 10-12hr    23 embryo 12-14hr    16 embryo 14-16hr    18 embryo 16-18hr    6 embryo 18-20hr    18 embryo 20-22hr    1 embryo 22-24hr    22 larva L1    1 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    9 white prepupae new    8 white prepupae 12hr    383 white prepupae 24hr    299 pupae 2d postWPP    259 pupae 3d postWPP    50 pupae 4d postWPP    26 adult male 01day    6 adult male 05day    8 adult male 30day    3 adult female 01day    3 adult female 05day    6 adult female 30day    7 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (629) embryo 02-04hr  (1985) embryo 04-06hr  (267) embryo 06-08hr  (167) embryo 08-10hr    88 embryo 10-12hr    23 embryo 12-14hr    16 embryo 14-16hr    18 embryo 16-18hr    6 embryo 18-20hr    18 embryo 20-22hr    1 embryo 22-24hr    22 larva L1    1 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    9 white prepupae new    8 white prepupae 12hr  (383) white prepupae 24hr  (299) pupae 2d postWPP  (259) pupae 3d postWPP    50 pupae 4d postWPP    26 adult male 01day    6 adult male 05day    8 adult male 30day    3 adult female 01day    3 adult female 05day    6 adult female 30day    7 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    629 embryo 02-04hr  (1985) embryo 04-06hr    267 embryo 06-08hr    167 embryo 08-10hr    88 embryo 10-12hr    23 embryo 12-14hr    16 embryo 14-16hr    18 embryo 16-18hr    6 embryo 18-20hr    18 embryo 20-22hr    1 embryo 22-24hr    22 larva L1    1 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    9 white prepupae new    8 white prepupae 12hr    383 white prepupae 24hr    299 pupae 2d postWPP    259 pupae 3d postWPP    50 pupae 4d postWPP    26 adult male 01day    6 adult male 05day    8 adult male 30day    3 adult female 01day    3 adult female 05day    6 adult female 30day    7 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    629 embryo 02-04hr    1985 embryo 04-06hr    267 embryo 06-08hr    167 embryo 08-10hr    88 embryo 10-12hr    23 embryo 12-14hr    16 embryo 14-16hr    18 embryo 16-18hr    6 embryo 18-20hr    18 embryo 20-22hr    1 embryo 22-24hr    22 larva L1    1 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    9 white prepupae new    8 white prepupae 12hr    383 white prepupae 24hr    299 pupae 2d postWPP    259 pupae 3d postWPP    50 pupae 4d postWPP    26 adult male 01day    6 adult male 05day    8 adult male 30day    3 adult female 01day    3 adult female 05day    6 adult female 30day    7 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    629 embryo 02-04hr    1985 embryo 04-06hr    267 embryo 06-08hr    167 embryo 08-10hr    88 embryo 10-12hr    23 embryo 12-14hr    16 embryo 14-16hr    18 embryo 16-18hr    6 embryo 18-20hr    18 embryo 20-22hr    1 embryo 22-24hr    22 larva L1    1 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    9 white prepupae new    8 white prepupae 12hr    383 white prepupae 24hr    299 pupae 2d postWPP    259 pupae 3d postWPP    50 pupae 4d postWPP    26 adult male 01day    6 adult male 05day    8 adult male 30day    3 adult female 01day    3 adult female 05day    6 adult female 30day    7 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0003270 expression level Developmental Stage   Expression Level embryo 00-02hr    629 embryo 02-04hr    1985 embryo 04-06hr    267 embryo 06-08hr    167 embryo 08-10hr    88 embryo 10-12hr    23 embryo 12-14hr    16 embryo 14-16hr    18 embryo 16-18hr    6 embryo 18-20hr    18 embryo 20-22hr    1 embryo 22-24hr    22 larva L1    1 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    9 white prepupae new    8 white prepupae 12hr    383 white prepupae 24hr    299 pupae 2d postWPP    259 pupae 3d postWPP    50 pupae 4d postWPP    26 adult male 01day    6 adult male 05day    8 adult male 30day    3 adult female 01day    3 adult female 05day    6 adult female 30day    7 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (629) embryo 02-04hr  (1985) embryo 04-06hr  (267) embryo 06-08hr  (167) embryo 08-10hr    88 embryo 10-12hr    23 embryo 12-14hr    16 embryo 14-16hr    18 embryo 16-18hr    6 embryo 18-20hr    18 embryo 20-22hr    1 embryo 22-24hr    22 larva L1    1 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    9 white prepupae new    8 white prepupae 12hr  (383) white prepupae 24hr  (299) pupae 2d postWPP  (259) pupae 3d postWPP    50 pupae 4d postWPP    26 adult male 01day    6 adult male 05day    8 adult male 30day    3 adult female 01day    3 adult female 05day    6 adult female 30day    7 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    629 embryo 02-04hr  1985 embryo 04-06hr    267 embryo 06-08hr    167 embryo 08-10hr    88 embryo 10-12hr    23 embryo 12-14hr    16 embryo 14-16hr    18 embryo 16-18hr    6 embryo 18-20hr    18 embryo 20-22hr    1 embryo 22-24hr    22 larva L1    1 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    9 white prepupae new    8 white prepupae 12hr    383 white prepupae 24hr    299 pupae 2d postWPP    259 pupae 3d postWPP    50 pupae 4d postWPP    26 adult male 01day    6 adult male 05day    8 adult male 30day    3 adult female 01day    3 adult female 05day    6 adult female 30day    7 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    629 embryo 02-04hr    1985 embryo 04-06hr    267 embryo 06-08hr    167 embryo 08-10hr    88 embryo 10-12hr    23 embryo 12-14hr    16 embryo 14-16hr    18 embryo 16-18hr    6 embryo 18-20hr    18 embryo 20-22hr    1 embryo 22-24hr    22 larva L1    1 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    9 white prepupae new    8 white prepupae 12hr    383 white prepupae 24hr    299 pupae 2d postWPP    259 pupae 3d postWPP    50 pupae 4d postWPP    26 adult male 01day    6 adult male 05day    8 adult male 30day    3 adult female 01day    3 adult female 05day    6 adult female 30day    7 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    629 embryo 02-04hr    1985 embryo 04-06hr    267 embryo 06-08hr    167 embryo 08-10hr    88 embryo 10-12hr    23 embryo 12-14hr    16 embryo 14-16hr    18 embryo 16-18hr    6 embryo 18-20hr    18 embryo 20-22hr    1 embryo 22-24hr    22 larva L1    1 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    9 white prepupae new    8 white prepupae 12hr    383 white prepupae 24hr    299 pupae 2d postWPP    259 pupae 3d postWPP    50 pupae 4d postWPP    26 adult male 01day    6 adult male 05day    8 adult male 30day    3 adult female 01day    3 adult female 05day    6 adult female 30day    7 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0003270    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0003270 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: No expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0003270 expression level Tissue   Expression Level Larval Central Nervous System    4.7 Larval Midgut    7.4 Larval Hindgut    6.8 Larval Malpighian Tubules    3.9 Larval Fat Body    4 Larval Salivary Gland    3.2 Larval Trachea    2.95 Larval Carcass    6.675 Adult Head    3.3 Adult Eye    2.825 Adult Brain    3.7 Adult Thoracic-Abdominal Ganglion    3 Adult Crop    5.8 Adult Midgut no informative data Adult Hindgut    4.8 Adult Malpighian Tubules    5.8 Adult Fat Body    6.2 Adult Salivary Gland no informative data Adult Heart    1.425 Adult VirginFemale Spermatheca    7.3 Adult InseminatedFemale Spermatheca    4.5 Adult Ovary    2.6 Adult Testis    1.9 Adult Male Accessory Gland no informative data Adult Carcass    6.4 Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    4.7 Larval Midgut    7.4 Larval Hindgut    6.8 Larval Malpighian Tubules    3.9 Larval Fat Body    4 Larval Salivary Gland    3.2 Larval Trachea    2.95 Larval Carcass    6.675 Adult Head    3.3 Adult Eye    2.825 Adult Brain    3.7 Adult Thoracic-Abdominal Ganglion    3 Adult Crop    5.8 Adult Midgut no informative data Adult Hindgut    4.8 Adult Malpighian Tubules    5.8 Adult Fat Body    6.2 Adult Salivary Gland no informative data Adult Heart    1.425 Adult VirginFemale Spermatheca    7.3 Adult InseminatedFemale Spermatheca    4.5 Adult Ovary    2.6 Adult Testis    1.9 Adult Male Accessory Gland no informative data Adult Carcass    6.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    4.7 Larval Midgut    7.4 Larval Hindgut    6.8 Larval Malpighian Tubules    3.9 Larval Fat Body    4 Larval Salivary Gland    3.2 Larval Trachea    2.95 Larval Carcass    6.675 Adult Head    3.3 Adult Eye    2.825 Adult Brain    3.7 Adult Thoracic-Abdominal Ganglion    3 Adult Crop    5.8 Adult Midgut no informative data Adult Hindgut    4.8 Adult Malpighian Tubules    5.8 Adult Fat Body    6.2 Adult Salivary Gland no informative data Adult Heart    1.425 Adult VirginFemale Spermatheca    7.3 Adult InseminatedFemale Spermatheca    4.5 Adult Ovary    2.6 Adult Testis    1.9 Adult Male Accessory Gland no informative data Adult Carcass    6.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    4.7 Larval Midgut    7.4 Larval Hindgut    6.8 Larval Malpighian Tubules    3.9 Larval Fat Body    4 Larval Salivary Gland    3.2 Larval Trachea    2.95 Larval Carcass    6.675 Adult Head    3.3 Adult Eye    2.825 Adult Brain    3.7 Adult Thoracic-Abdominal Ganglion    3 Adult Crop    5.8 Adult Midgut no informative data Adult Hindgut    4.8 Adult Malpighian Tubules    5.8 Adult Fat Body    6.2 Adult Salivary Gland no informative data Adult Heart    1.425 Adult VirginFemale Spermatheca    7.3 Adult InseminatedFemale Spermatheca    4.5 Adult Ovary    2.6 Adult Testis    1.9 Adult Male Accessory Gland no informative data Adult Carcass    6.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0003270 expression level Tissue   Expression Level Larval Central Nervous System    4.7 Larval Midgut    7.4 Larval Hindgut    6.8 Larval Malpighian Tubules    3.9 Larval Fat Body    4 Larval Salivary Gland    3.2 Larval Trachea    2.95 Larval Carcass    6.675 Adult Head    3.3 Adult Eye    2.825 Adult Brain    3.7 Adult Thoracic-Abdominal Ganglion    3 Adult Crop    5.8 Adult Midgut no informative data Adult Hindgut    4.8 Adult Malpighian Tubules    5.8 Adult Fat Body    6.2 Adult Salivary Gland no informative data Adult Heart    1.425 Adult VirginFemale Spermatheca    7.3 Adult InseminatedFemale Spermatheca    4.5 Adult Ovary    2.6 Adult Testis    1.9 Adult Male Accessory Gland no informative data Adult Carcass    6.4 Expression Level Scale  None   Low  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    4.7 Larval Midgut    7.4 Larval Hindgut    6.8 Larval Malpighian Tubules    3.9 Larval Fat Body    4 Larval Salivary Gland    3.2 Larval Trachea    2.95 Larval Carcass    6.675 Adult Head    3.3 Adult Eye    2.825 Adult Brain    3.7 Adult Thoracic-Abdominal Ganglion    3 Adult Crop    5.8 Adult Midgut no informative data Adult Hindgut    4.8 Adult Malpighian Tubules    5.8 Adult Fat Body    6.2 Adult Salivary Gland no informative data Adult Heart    1.425 Adult VirginFemale Spermatheca    7.3 Adult InseminatedFemale Spermatheca    4.5 Adult Ovary    2.6 Adult Testis    1.9 Adult Male Accessory Gland no informative data Adult Carcass    6.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    4.7 Larval Midgut    7.4 Larval Hindgut    6.8 Larval Malpighian Tubules    3.9 Larval Fat Body    4 Larval Salivary Gland    3.2 Larval Trachea    2.95 Larval Carcass    6.675 Adult Head    3.3 Adult Eye    2.825 Adult Brain    3.7 Adult Thoracic-Abdominal Ganglion    3 Adult Crop    5.8 Adult Midgut no informative data Adult Hindgut    4.8 Adult Malpighian Tubules    5.8 Adult Fat Body    6.2 Adult Salivary Gland no informative data Adult Heart    1.425 Adult VirginFemale Spermatheca    7.3 Adult InseminatedFemale Spermatheca    4.5 Adult Ovary    2.6 Adult Testis    1.9 Adult Male Accessory Gland no informative data Adult Carcass    6.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    4.7 Larval Midgut    7.4 Larval Hindgut    6.8 Larval Malpighian Tubules    3.9 Larval Fat Body    4 Larval Salivary Gland    3.2 Larval Trachea    2.95 Larval Carcass    6.675 Adult Head    3.3 Adult Eye    2.825 Adult Brain    3.7 Adult Thoracic-Abdominal Ganglion    3 Adult Crop    5.8 Adult Midgut no informative data Adult Hindgut    4.8 Adult Malpighian Tubules    5.8 Adult Fat Body    6.2 Adult Salivary Gland no informative data Adult Heart    1.425 Adult VirginFemale Spermatheca    7.3 Adult InseminatedFemale Spermatheca    4.5 Adult Ovary    2.6 Adult Testis    1.9 Adult Male Accessory Gland no informative data Adult Carcass    6.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut no informative data Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland no informative data Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    3.3   NA  Eye    2.825   NA  Brain    3.7   4.7  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    3   NA  Crop    5.8   7.4  Midgut    no informative data   6.8  Hindgut    4.8   3.9  Malpighian Tubules    5.8   4  Fat Body    6.2   3.2  Salivary Gland    no informative data   NA  Heart    1.425   2.95  Trachea    NA   NA  VirginFemale Spermatheca    7.3   NA  InseminatedFemale Spermatheca    4.5   NA  Ovary    2.6   NA  Testis    1.9   NA  Male Accessory Gland    no informative data   6.675  Carcass    6.4 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_31
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003270 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10393-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4ap-md544 amosScer\UAS.cGa lethal, with Scer\GAL4Bx-MS1096 amosScer\UAS.cGa lethal, with Scer\GAL4en-e16E amosScer\UAS.cGa lethal, with Scer\GAL4pnr-MD237 amosScer\UAS.cGa lethal, with Scer\GAL4tsh-md621 amosScer\UAS.cGa lethal | larval stage, with Scer\GAL4dac-p7d23 amosScer\UAS.cGa lethal | larval stage, with Scer\GAL4dpp.blk1 amosScer\UAS.cGa lethal | larval stage, with Scer\GAL4h-H10 amosScer\UAS.cGa lethal | pharate adult stage, with Scer\GAL4C-765 amosScer\UAS.cGa lethal | pupal stage, with Scer\GAL4Bx-MS1096 amosScer\UAS.cGa lethal | pupal stage, with Scer\GAL4dpp.blk1 amosScer\UAS.cGa lethal | pupal stage, with Scer\GAL4pnr-MD237 amosGD1521 lethal | recessive amosRoi-1 amosTft-RM11 viable amos1 amos2 amos3 amosRoi-1 amosTft-Rev54 amosTft-RM9 viable, with Scer\GAL4GMR.12 amosScer\UAS.cGa viable (with Df(2L)M36F-S6) amos1 Other Phenotypes Allele neuroanatomy defective, with Scer\GAL4sca-537.4 amosScer\UAS.cHa neuroanatomy defective | embryonic stage amos1 visible amosRoi-1 visible, with Scer\GAL4C-765 amosScer\UAS.cGa visible, with Scer\GAL4hs.PB amosScer\UAS.cGa amosScer\UAS.cHa visible, with Scer\GAL4OK384 amosScer\UAS.cGa visible, with Scer\GAL4sca-109-68 amosScer\UAS.cGa visible | dominant amosTft visible | heat sensitive, with Scer\GAL4hs.PB amosScer\UAS.cGa visible | recessive amosTft Phenotype manifest in Allele abdominal dorsal bipolar neuron dbp amosTft-RM11 amosdsRNA.cHa abdominal dorsal bipolar neuron dbp | ectopic amosTft adult head & olfactory sensory organ | ectopic, with Scer\GAL4sca-109-68 amosScer\UAS.cGa adult mesothoracic segment amosTft adult thorax & macrochaeta, with Scer\GAL4sca-109-68 amosScer\UAS.cGa adult thorax & olfactory sensory organ | ectopic, with Scer\GAL4sca-109-68 amosScer\UAS.cGa antenna, with Scer\GAL4OK384 amosScer\UAS.cGa antennal segment 1 & olfactory sensory organ | ectopic, with Scer\GAL4hs.PB amosScer\UAS.cGa antennal segment 2 & olfactory sensory organ | ectopic, with Scer\GAL4hs.PB amosScer\UAS.cGa antennal sense organ, with Scer\GAL4OK384 amosScer\UAS.cGa antennal sense organ | ectopic amosTft antennal sense organ | ectopic, with Scer\GAL4OK384 amosScer\UAS.cGa chaeta | ectopic amosTft cone cell amosRoi-1 dorsal abdominal cluster amosTft amosTft-RM11 dorsal multidendritic neuron amosTft-RM11 dorsocentral bristle | supernumerary amosTft embryonic/larval neuron | ectopic, with Scer\GAL4sca-537.4 amosScer\UAS.cHa embryonic antennal sense organ amos1 eye amosRoi-1 eye disc amosRoi-1 eye photoreceptor cell amosRoi-1 eye photoreceptor cell | somatic clone amosRoi-1 eye photoreceptor cell | supernumerary amosRoi-1 macrochaeta, with Scer\GAL4sca-109-68 amosScer\UAS.cGa macrochaeta | ectopic amosTft macrochaeta | ectopic, with Scer\GAL4dpp.blk1 amosScer\UAS.cGa macrochaeta | ectopic & adult head, with Scer\GAL4C-765 amosScer\UAS.cGa macrochaeta | ectopic & antenna amos1 amos2 macrochaeta | ectopic & antenna (with Df(2L)M36F-S6) amos1 amos2 amos3 macrochaeta | ectopic & mesothoracic tergum, with Scer\GAL4C-765 amosScer\UAS.cGa mechanosensory chaeta | ectopic, with Scer\GAL4hs.PB amosScer\UAS.cGa mesothoracic metatarsus amosTft mesothoracic tarsal bristle amosTft mesothoracic tergum amosTft metathoracic laterotergite amosTft microchaeta & adult thorax, with Scer\GAL4sca-109-68 amosScer\UAS.cGa microchaeta | ectopic amosTft multidendritic neuron | ectopic, with Scer\GAL4h-1J3 amosScer\UAS.cHa multidendritic neuron | ectopic, with Scer\GAL4sca-537.4 amosScer\UAS.cHa olfactory neuron & embryonic antennal sense organ amos1 olfactory receptor neuron amos3 ommatidium amosRoi-1 ommatidium, with Scer\GAL4hs.PB amosScer\UAS.cGa pigment cell amosRoi-1 postalar bristle | supernumerary amosTft rhabdomere amosRoi-1 rhabdomere | somatic clone amosRoi-1 rhabdomere R7 amosRoi-1 rhabdomere R8 amosRoi-1 scolopidial neuron | ectopic, with Scer\GAL4h-1J3 amosScer\UAS.cHa scolopidial neuron | ectopic, with Scer\GAL4sca-537.4 amosScer\UAS.cHa scutellar bristle | supernumerary amosTft scutellum amosTft scutellum & chordotonal organ | ectopic, with Scer\GAL4sca-109-68 amosScer\UAS.cGa sense organ | ectopic, with Scer\GAL4sca-109-68 amosScer\UAS.cGa sensillum basiconicum & antenna amos1 amos2 sensillum basiconicum & antenna (with Df(2L)M36F-S6) amos1 amos2 amos3 sensillum basiconicum of antennal segment 3 | ectopic, with Scer\GAL4OK384 amosScer\UAS.cGa sensillum campaniformium | ectopic, with Scer\GAL4hs.PB amosScer\UAS.cGa sensillum campaniformium | ectopic & wing, with Scer\GAL4C-765 amosScer\UAS.cGa sensillum coeloconicum of antennal segment 3 | ectopic, with Scer\GAL4OK384 amosScer\UAS.cGa sensillum trichodeum of antennal segment 3 amos1 amos2 sensillum trichodeum of antennal segment 3 (with Df(2L)M36F-S6) amos1 amos2 amos3 sensillum trichodeum of antennal segment 3 | ectopic, with Scer\GAL4OK384 amosScer\UAS.cGa sensory mother cell & antennal disc amos1 amos3 sensory mother cell | ectopic amosTft sensory mother cell | ectopic & dorsal mesothoracic disc, with Scer\GAL4dpp.blk1 amosScer\UAS.cGa sensory neuron | dorsal amos1 sensory neuron | ectopic, with Scer\GAL4h-1J3 amosScer\UAS.cHa tormogen cell amosTft ventral multidendritic neuron, with Scer\GAL4sca-537.4 amosScer\UAS.cHa wing disc amosTft wing disc, with Scer\GAL4dpp.blk1 amosScer\UAS.cGa wing sensillum | ectopic, with Scer\GAL4C-765 amosScer\UAS.cGa wing sensillum | ectopic, with Scer\GAL4hs.PB amosScer\UAS.cHa wing vein L3 & chordotonal organ | ectopic, with Scer\GAL4sca-109-68 amosScer\UAS.cGa wing vein L3 & external sensory organ | ectopic, with Scer\GAL4sca-109-68 amosScer\UAS.cGa wing vein L3 & olfactory sensory organ | ectopic, with Scer\GAL4sca-109-68 amosScer\UAS.cGa
Classical Alleles ( 11 )
For All Classical Alleles Show
Allele of amos Class Mutagen Stocks Known lesion amosRoi-1 gain of function allele spontaneous 102 Yes amosTft gain of function allele X ray 37 Yes amos1 loss of function allele ethyl methanesulfonate 0 Yes amos2 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes amos3 loss of function allele ethyl methanesulfonate 0 Yes amosRoi-Rev PM hybrid dysgenesis P-element activity 0 Yes amosTft-Rev47 wild-type allele X ray 0 -- amosTft-Rev54 wild-type allele X ray 0 -- amosTft-RM11 hypomorphic allele - genetic evidence X ray 0 -- amosTft-RM9 X ray 0 -- amosunspecified 0 --
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of amos Class Mutagen Stocks Known lesion amosGD1521 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes amosKK104651 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes amosdsRNA.cHa in vitro construct - RNAi 0 Yes amosScer\UAS.cGa in vitro construct - regulatory fusion 0 Yes amosScer\UAS.cHa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)E71 (Wright et al., 1976, Ganetzky, 1977) Df(2L)Exel6041 (Ryder, 2004.4.26) Df(2L)hk18 (Brittnacher and Ganetzky, 1983) Df(2L)hk39 (Brittnacher and Ganetzky, 1983) Df(2L)M36F-2 (Marygold, 2005.1.19) Df(2L)M36F-S5 (Chien, 1999.9.15) Df(2L)M36F-S6 (Villa-Cuesta et al., 2003, Marygold, 2005.1.19) Df(2L)pr-A8 (Ganetzky, 1977) Df(2L)TW3 (Wright et al., 1976) Df(2L)TW50 (Wright et al., 1976) Df(2L)TW137 (Wright et al., 1976) Df(2L)TW203 (Chien, 1999.9.15, Wright et al., 1981) In(2L)TW47 (Wright et al., 1976)
Not disrupted in	Df(2L)E55 (Wright et al., 1976) Df(2L)pr21 (Brittnacher and Ganetzky, 1983) Df(2L)pr26 (Brittnacher and Ganetzky, 1983) Df(2L)pr47 (Brittnacher and Ganetzky, 1983) Df(2L)pr49 (Brittnacher and Ganetzky, 1983) Df(2L)pr65 (Brittnacher and Ganetzky, 1983) Df(2L)pr67 (Brittnacher and Ganetzky, 1983) Df(2L)pr69 (Brittnacher and Ganetzky, 1983) Df(2L)pr-A14 (Ganetzky, 1977) Df(2L)pr-A20 (Ganetzky, 1977) Df(2L)pr-B12 (Ganetzky, 1977, Brittnacher and Ganetzky, 1983) Df(2L)Sd2 (Brittnacher and Ganetzky, 1983) Df(2L)Sd14 (Brittnacher and Ganetzky, 1983) Df(2L)Sd37 (Ganetzky, 1977, Brittnacher and Ganetzky, 1983) Df(2L)Sd57 (Brittnacher and Ganetzky, 1983) Df(2L)Sd68 (Brittnacher and Ganetzky, 1983) Df(2L)Sd77 (Brittnacher and Ganetzky, 1983) Df(2L)TW1 (Wright et al., 1976) Df(2L)TW2 (Wright et al., 1976) Df(2L)TW9 (Wright et al., 1976) Df(2L)TW12 (Wright et al., 1976) Df(2L)TW65 (Wright et al., 1976, Ganetzky, 1977) Df(2L)TW84 (Wright et al., 1976) Df(2L)TW119 (Wright et al., 1976) Df(2L)TW130 (Wright et al., 1976) Df(2L)TW150 (Wright et al., 1976) Df(2L)TW158 (Wright et al., 1976, Ganetzky, 1977) Df(2L)TW161 (Wright et al., 1976, Ganetzky, 1977)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1521} NA P{KK104651} NA P{UAS-amos.G} NA P{UAS-amos.H} NA characterization construct P{amos-GAL4.Z} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{}Idgf2Roi-Rev NA
Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function
CV term Evidence References
protein heterodimerization activity inferred from physical interaction with da (Huang et al., 2000) contributes_to RNA polymerase II regulatory region DNA binding inferred from physical interaction with da (Huang et al., 2000)
Biological Process
CV term Evidence References
sensory organ boundary specification inferred from mutant phenotype (Villa-Cuesta et al., 2003, Lai, 2003) sensory organ development inferred from mutant phenotype (Grillenzoni et al., 2007) sensory organ precursor cell fate determination inferred from direct assay (Huang et al., 2000)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
sequence-specific DNA binding transcription factor activity inferred from sequence or structural similarity with UniProtKB:P48985 (FlyBase, 1992-)
Biological Process
CV term Evidence References
nervous system development non-traceable author statement (Swiss-Prot Project Members, 2002.3.1) regulation of transcription, DNA-dependent inferred from sequence or structural similarity with UniProtKB:P48985 (FlyBase, 1992-) sensory organ development traceable author statement (Skaer et al., 2002) sensory organ precursor cell fate determination traceable author statement (Hallem and Carlson, 2004)
Cellular Component
CV term Evidence References
nucleus inferred from sequence or structural similarity with UniProtKB:P48985 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions amos allele Gene References amos1 sc (zur Lage et al., 2003) amosRoi-1 ato (Chanut et al., 2002) da (Chanut et al., 2002) Dr (Heberlein et al., 1993) hh (Heberlein et al., 1993, Chanut et al., 2002) Pino (Anholt et al., 2003) ro (Heberlein et al., 1993, Chanut et al., 2002) smi26D (Anholt et al., 2003) amosRoi-Rev ro (Chanut et al., 2002) amosScer\UAS.cGa lz (Goulding et al., 2000) amosScer\UAS.cHa ato (Huang et al., 2000) da (Huang et al., 2000) amosTft Brd (Lai, 2003) da (Lai, 2003) Dl (Villa-Cuesta et al., 2003) E(spl) (Villa-Cuesta et al., 2003) emc (Villa-Cuesta et al., 2003) H (Villa-Cuesta et al., 2003) h (Villa-Cuesta et al., 2003) N (Villa-Cuesta et al., 2003) unspecified ase (Villa-Cuesta et al., 2003) da (Goulding et al., 2000)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 61105 DroID - A comprehensive database of gene and protein interactions. • FBgn0003270 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35110
Orthologs
Genome-wide drosophilid orthologs	Dana\GF14839 Dere\GG21703 Dgri\GH10530 Dmoj\GI17198 Dper\GL18743 Dpse\GA10296 Dsec\GM17083 Dsim\GD21828 Dvir\GJ19805 Dwil\GK24655 Dyak\GE12726
Curated drosophilid orthologs	Dpse\GA10296
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AGAP011985-PA Anopheles gambiae (mosquito) XP_001121050.1 Apis mellifera (honey bee) BGIBMGA008990-PA Bombyx mori (silk worm) ENSBTAP00000028589 Bos taurus (bovine) CN15376 Caenorhabditis brenneri (small nematode) ENSCAFP00000018365 Canis familiaris (dog) JA03472 Caenorhabditis japonica (nematode) CPIJ005359 Culex pipens (mosquito) ENSCPOP00000020202 Cavia porcellus (guinea pig) 227979 Daphnia pulex (daphnia) ENSDARP00000010424 Danio rerio (zebra fish) ENSDARP00000043594 Danio rerio (zebra fish) ENSDARP00000047555 Danio rerio (zebra fish) ENSMODP00000028479 Monodelphis domestica (gray opossum) ENSMMUP00000028847 Macaca mulatta (rhesus monkey) ENSMUSP00000007949 Mus musculus (house mouse) 243969 Nematostella vectensis (starlet anemone) ENSORLP00000006139 Oryzias latipes (japanese killifish) ENSPTRP00000059365 Pan troglodytes (chimpanzee) ENSRNOP00000027597 Rattus norvegicus (norway rat) XP_974297.1 Tribolium castaneum (red flour beetle) ENSTNIP00000001603 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000032008 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000050295 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • ISCW003677 FBgn0230450 FBgn0226615 FBgn0206947 FBgn0193248 FBgn0171995 JGI_V11_29107 FBgn0070354 FBgn0156344 FBgn0139942 FBgn0118011 FBgn0113881 FBgn0091866 CPIJ000953 AGAP007824 AAEL001652 GLEAN_03170
Stocks & Reagents
Stocks Listed in FlyBase ( 141 )
Bloomington	424 amosTft/CyO 1821 amosTft P{neoFRT}40A/CyO 25 Df(2L)cl-h1/CyO, amosRoi-1 1065 Dp(2;2)C619/SM1, amosRoi-1 2473 M(2)** amosTft/CyO 6958 Wnt2O/CyO, amosRoi-1
Kyoto	105904 amosTft/CyO 106524 amosTft P{neoFRT}40A/CyO 105684 Df(2L)cl-h1/CyO, amosRoi-1 106193 Dp(2;2)C619/SM1, amosRoi-1
VDRC	v100511 P{KK104651}VIE-260B v11796 w1118; P{GD1521}v11796
	More stocks available...
Genomic Clones ( 2 )
	BACR13N02 BACR25C02 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 2 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones	RT01053 RT01153
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0003270 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35110
Antibody Information
Other Information
Discoverer
	Ritterhouse, 25th June 1952. Ives, 18th Nov. 1947.
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: amos Tft (Lai and Rubin, 2003) Source for merge of: Roi amos (Chanut et al., 2002)
Additional comments	The "Roi" rough eye mutant allele is due to an inversion between 36A and 37A (In(2L)Roi[1]). The proximal breakpoint is 2.6kb downstream of "amos" and is within the last exon of CG15160. The distal breakpoint is within the first intron of CG5888. Several lines of evidence suggest that the "Roi" phenotype is caused by a gain-of-function allele of "amos" rather than being due to an effect of the inversion on another gene; "amos" is expressed in high levels in a broad area surrounding the morphogenetic furrow in "Roi" third instar larvae (in contrast to wild type), overexpression of "amos" in the eye disc can produce a phenotype similar to that of "Roi" and reversion of the phenotype has been achieved by the insertion of a P-element a few kilobases downstream of "amos" which is associated with a severe reduction of "amos" expression in the eye. In addition, although the location of the In(2L)Roi[1] breakpoints means that a chimeric gene could potentially be formed from the 5' portion of CG5888 and the 3' portion of CG15160, this chimeric RNA has not been detected in "Roi" mutants and although dac is also within the inverted segment it does not appear to be implicated in the "Roi" phenotype. (Chanut et al., 2002)
Other Comments
	amos is required for the normal formation of the larval dorsal organ. (Grillenzoni et al., 2007) amos is a proneural gene for olfactory sensilla, most likely the sensilla basiconica and trichodea. (Goulding et al., 2000) amos promotes multiple dendritic neuron formation. (Huang et al., 1999, Huang et al., 2000) Loss of amos function eliminates multiple dendritic neurons in embryos. Misexpression of amos results in ectopic multiple dendritic neurons. (Huang et al., 1999)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_058098 RefSeq (Proteins) • NP_477446 DDBJ / EMBL / GenBank • AAD45410 AAF53678 AC007137 AF166113 Entrez Gene - A searchable database of RefSeq genes. • 35110 UniProtKB/Swiss-Prot • Q9Y0A7
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Helix-loop-helix DNA-binding (IPR011598)
Linkouts
	BioGRID - A database of protein and genetic interactions • 61105 DroID - A comprehensive database of gene and protein interactions. • FBgn0003270 DRSC - Results from RNAi screens. • FBgn0003270 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003270 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10393-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0003270 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35110 InParanoid A subset of ortholog calls from InParanoid. • AGAP011985-PA Anopheles gambiae (mosquito) XP_001121050.1 Apis mellifera (honey bee) BGIBMGA008990-PA Bombyx mori (silk worm) ENSBTAP00000028589 Bos taurus (bovine) CN15376 Caenorhabditis brenneri (small nematode) ENSCAFP00000018365 Canis familiaris (dog) JA03472 Caenorhabditis japonica (nematode) CPIJ005359 Culex pipens (mosquito) ENSCPOP00000020202 Cavia porcellus (guinea pig) 227979 Daphnia pulex (daphnia) ENSDARP00000010424 Danio rerio (zebra fish) ENSDARP00000043594 Danio rerio (zebra fish) ENSDARP00000047555 Danio rerio (zebra fish) ENSMODP00000028479 Monodelphis domestica (gray opossum) ENSMMUP00000028847 Macaca mulatta (rhesus monkey) ENSMUSP00000007949 Mus musculus (house mouse) 243969 Nematostella vectensis (starlet anemone) ENSORLP00000006139 Oryzias latipes (japanese killifish) ENSPTRP00000059365 Pan troglodytes (chimpanzee) ENSRNOP00000027597 Rattus norvegicus (norway rat) XP_974297.1 Tribolium castaneum (red flour beetle) ENSTNIP00000001603 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000032008 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000050295 Xenopus tropicalis (frog) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /hjmuller/amos1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35110 modMine - Data generated by the modENCODE project. • FBgn0003270 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • ISCW003677 FBgn0230450 FBgn0226615 FBgn0206947 FBgn0193248 FBgn0171995 JGI_V11_29107 FBgn0070354 FBgn0156344 FBgn0139942 FBgn0118011 FBgn0113881 FBgn0091866 CPIJ000953 AGAP007824 AAEL001652 GLEAN_03170 REDfly - A database of transcriptional regulatory elements. • FBgn0003270
Synonyms & Secondary IDs ( 14 )
Reported As
Symbol Synonym	Amos (Kenyon et al., 2001, Sen et al., 2005) amos (Jafar-Nejad et al., 2006, Hoskins et al., 2005, Maung and Jarman, 2007, Vicente-Crespo et al., 2008, Grillenzoni et al., 2007, Holohan et al., 2006, Jarman et al., 2008, Lage and Jarman, 2008, Benton et al., 2009, Brandt, 2006, zur Lage and Jarman, 2010, Bardin et al., 2010, Cave et al., 2011, Goto et al., 2011) asolo (Huang et al., 1999) bHLHa10 (Stevens et al., 2008) CG10393 (Stevens et al., 2008, Stevens et al., 2008, Keleman et al., 2009.8.5, Brandt, 2006) Roi (Heberlein et al., 1993, Käfer et al., 2007, Hilgenfeldt et al., 2008) rolo   Tft (Sur et al., 1995, Held, 1990, Brittnacher and Ganetzky, 1983, Wright et al., 1981, Ganetzky, 1977, Wright et al., 1976, )
Name Synonym	Absent MD neurons (Cho et al., 2005) absent MD neurons and olfactory sensilla   absent md neurons and olfactory sensilla (Benton et al., 2009) amos (Bardin et al., 2010) Rough eye   Rough-eye (Käfer et al., 2007) Tufted
Secondary FlyBase IDs
	FBgn0003689 FBgn0027104
References ( 93 )
Generate a list of	All references relating to this gene ( 93 )
List References by type	Research paper  ( 53 ) Supplementary material  ( 5 ) Review  ( 9 ) Personal communication to FlyBase  ( 6 ) Abstract  ( 13 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 1 ) Protein sequence record  ( 1 ) Book  ( 1 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 5 )
	Cave et al., 2011, Mol. Cell. Biol. 31(1): 22--29 Differential Regulation of Transcription through Distinct Suppressor of Hairless DNA Binding Site Architectures during Notch Signaling in Proneural Clusters. [FBrf0212524] Goto et al., 2011, J. Neurosci. 31(14): 5454--5459 Sexually dimorphic shaping of interneuron dendrites involves the hunchback transcription factor. [FBrf0213400] Xie et al., 2011, Genetics 188(4): 823--834 Inhibition of RNA interference and modulation of transposable element expression by cell death in Drosophila. [FBrf0214636] Bardin et al., 2010, Development 137(5): 705--714 Transcriptional control of stem cell maintenance in the Drosophila intestine. [FBrf0209974] zur Lage and Jarman, 2010, BMC Dev. Biol. 10: 34 The function and regulation of the bHLH gene, cato, in Drosophila neurogenesis. [FBrf0210540] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...