rpA1, RpP1, Tp1, LP2, Ribosomal protein A1
Gene model reviewed during 5.50
There is only one protein coding transcript and one polypeptide associated with this gene
P1 and P2 exist as dimers at the large ribosomal subunit.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\RpLP2 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\RpLP2 in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: RpP1 BcDNA:SD22208
The RpLP2 gene may have been derived from a parental gene that has since degraded or been lost in D. melanogaster, but is still present in other Drosophilids.
The genetically defined "M(2)53" locus (characterized by previous aneuploidy analyses) likely comprises two separable, closely linked Minute genes ("RpLP2" and "RpS15").
Source for merge of RpP1 BcDNA:SD22208 was a shared cDNA ( date:030728 ).
Not allelic to M(2)53. RpA1 transformants did not rescue M(2)531 (Qian et al., 1988)
Likely Minute gene.
Deletions removing RpLP2 but no other cytoplasmic ribosomal protein-encoding genes show Minute phenotypes.
RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
In a sample of 79 genes with multiple introns, 33 showed significant heterogeneity in G+C content among introns of the same gene and significant positive correspondence between the intron and the third codon position G+C content within genes. These results are consistent with selection adding against preferred codons at the start of genes.
An 89 nucleotide sequence in the untranslated RpLP2 mRNA leader is by itself sufficient to confer full translational regulation to a heterologous mRNA.
Translation of RpLP2 RNA in early embryos injected with initiation factors has been studied.
RNA blot analysis demonstrates that coordination between r-protein and rRNA synthesis is achieved by regulating translation of r-protein mRNAs in early embryos and by decreasing their abundance in adult tissues.
Encodes protein homologous to 'A' family of eucaryotic ribosomal proteins involved in the initiation and elongation steps of protein synthesis (FBrf0047123). mRNA of the RpLP2 gene is regulated at the level of translation; it is associated with polysomes during oogenesis and late embryonic stages (FBrf0043241). An antisense RpLP2 gene (carrying a heat shock promoter), transformed into the fly genome, disrupts oogenesis and results in female sterility (FBrf0048956).