FB2025_01 , released February 20, 2025
Gene: Dmel\Polr2F
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General Information
Symbol
Dmel\Polr2F
Species
D. melanogaster
Name
RNA polymerase II, I and III subunit F
Annotation Symbol
CG1163
Feature Type
protein_coding_gene
FlyBase ID
FBgn0003275
Gene Model Status
Current
Stock Availability
4 publicly available
Enzyme Name (EC)
DNA-directed RNA polymerase (2.7.7.6)
Gene Summary
RNA polymerase II, I and III subunit F (Polr2F) encodes a shared subunit of RNA polymerases I, II, and III. [Date last reviewed: 2018-09-20] (FlyBase Gene Snapshot)
All Summaries
Also Known As

RNA polymerase II, Pol II, RpII18, PolII, RNA Pol II

Key Links
Genomic Location
Cytogenetic map
83A1-83A1
Sequence location
Recombination map
3-47.5
RefSeq locus
NT_033777 REGION:5371795..5372397
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (10 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables DNA binding
(InterPro Project Members, 2004-)
contributes_to DNA-directed 5'-3' RNA polymerase activity
inferred from sequence or structural similarity with UniProtKB:P20435
(Gene Ontology Curators, 2002-, Aoyagi and Wassarman, 2000)
enables DNA-directed 5'-3' RNA polymerase activity
(InterPro Project Members, 2004-)
Biological Process (4 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
involved_in DNA-templated transcription
(InterPro Project Members, 2004-)
involved_in transcription by RNA polymerase II
inferred from sequence or structural similarity with UniProtKB:P20435
(Aoyagi and Wassarman, 2000)
inferred from biological aspect of ancestor with PANTHER:PTN008715205
(GO Reference Genome Project, 2011-)
involved_in transcription by RNA polymerase I
inferred from sequence or structural similarity with UniProtKB:P20435
(Gene Ontology Curators, 2002-)
inferred from biological aspect of ancestor with PANTHER:PTN008715205
(GO Reference Genome Project, 2011-)
involved_in tRNA transcription by RNA polymerase III
inferred from sequence or structural similarity with UniProtKB:P20435
(Gene Ontology Curators, 2002-)
inferred from biological aspect of ancestor with PANTHER:PTN008715205
(GO Reference Genome Project, 2011-)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
part_of RNA polymerase II, core complex
inferred from direct assay
(Hamilton et al., 1993)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
located_in nucleus
inferred from electronic annotation with InterPro:IPR028363
(InterPro Project Members, 2004-)
part_of RNA polymerase I complex
inferred from biological aspect of ancestor with PANTHER:PTN000080812
(GO Reference Genome Project, 2011-)
inferred from sequence or structural similarity with UniProtKB:P20435
(Gene Ontology Curators, 2002-)
part_of RNA polymerase II, core complex
inferred from biological aspect of ancestor with PANTHER:PTN000080812
(GO Reference Genome Project, 2011-)
inferred from electronic annotation with InterPro:IPR028363
(InterPro Project Members, 2004-)
inferred from sequence or structural similarity with UniProtKB:P20435
(Aoyagi and Wassarman, 2000)
part_of RNA polymerase III complex
inferred from biological aspect of ancestor with PANTHER:PTN000080812
(GO Reference Genome Project, 2011-)
inferred from sequence or structural similarity with UniProtKB:P20435
(Gene Ontology Curators, 2002-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family. (Q24320)
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
DNA-directed 5'-3' RNA polymerase activity
RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate (2.7.7.6)
Summaries
Gene Snapshot
RNA polymerase II, I and III subunit F (Polr2F) encodes a shared subunit of RNA polymerases I, II, and III. [Date last reviewed: 2018-09-20]
Gene Group (FlyBase)
RNA POLYMERASE II -
RNA Polymerase II (RNAP II) synthesizes mRNAs and a variety of non-coding RNAs, including snRNAs, snoRNAs, microRNAs, piRNAs and lncRNAs. It comprises 12-13 subunits (13 in D. melanogaster), ten of which form a structurally conserved catalytic core with additional subunits located on the periphery. Notably, five RNAP II subunits are shared with the other two nuclear RNAPs. For transcription initiation, RNAPII assembles with the general transcription factors at promoter DNA to form the pre-initiation complex. (Adapted from FBrf0247389, FBrf0228779, FBrf0213652, PMID:25693126, PMID:23463798 and PMID:17318225.)
RNA POLYMERASE I -
RNA polymerase I (RNAP I) synthesizes the ribosomal RNA precursor that is processed into most ribosomal RNAs (rRNAs). It comprises 12-14 subunits (12 in D. melanogaster), ten of which form a structurally conserved catalytic core with additional subunits located on the periphery. Notably, five RNAP I subunits are shared with the other two nuclear RNAPs, and two others are shared between RNAPs I and III. (Adapted from FBrf0247389.)
RNA POLYMERASE III -
RNA polymerase III (RNAP III) synthesizes short, non-coding RNAs including tRNAs, the small 5S rRNA and the U6 snRNA. It comprises 17 subunits, ten of which form a structurally conserved catalytic core with additional subunits located on the periphery. Notably, five RNAP III subunits are shared among all three RNAPs and two others are shared between RNAPs I and III. (Adapted from FBrf0247389.)
RNA POLYMERASE CATALYTIC SUBUNITS -
DNA-directed RNA polymerases (RNAPs) catalyze the synthesis of RNA from DNA templates. Nuclear DNA is transcribed by three different multi-subunit polymerases, RNAPs I, II and III, which synthesize mRNAs, rRNAs, tRNAs and other non-coding RNAs. Although composed of between 12-17 subunits, all three nuclear RNAPs contain a ten-subunit catalytic core. Mitochondrial RNA is synthesized by a single subunit RNA polymerase. DNA primases are a class of RNA polymerases that catalyse the synthesis of short RNA primers that are extended by DNA polymerases during DNA replication. (Adapted from PMID:22365827 and PMID:19540940.)
Protein Function (UniProtKB)
DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, Polr2F/RPB6 is part of the clamp element and together with parts of Polr2A/RPB1 and RPB2 forms a pocket to which the Polr2D/RPB4-Polr2G/RPB7 subcomplex binds (By similarity).
(UniProt, Q24320)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Polr2F for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q24320)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.45

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Polr2F-RA
FBtr0078787
NM_080171
541
131
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Polr2F-PA
FBpp0078433
14.7
131
3.91
Q24320
NP_524910
AAF52039
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.

(UniProt, Q24320)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Polr2F using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

4.60

Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
part_of RNA polymerase II, core complex
inferred from direct assay
(Hamilton et al., 1993)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Polr2F in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 0 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Polr2F
Transgenic constructs containing regulatory region of Polr2F
Aberrations (Deficiencies and Duplications) ( 0 )
Inferred from experimentation ( 0 )
Inferred from location ( 4 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal - all die during larval stage, with Scer\GAL4Mef2.PR
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (1)
Hsap\POLR2F
14 of 14
Yes
Yes
1  
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (1)
Rnor\Polr2f
14 of 14
Yes
Yes
Mus musculus (laboratory mouse) (1)
Mmus\Polr2f
12 of 14
Yes
Yes
Xenopus tropicalis (Western clawed frog) (2)
Xtro\polr2f
11 of 13
Yes
Yes
Xtro\tinf2
1 of 13
No
Yes
Danio rerio (Zebrafish) (1)
Drer\polr2f
14 of 14
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\rpb-6
14 of 14
Yes
Yes
Anopheles gambiae (African malaria mosquito) (1)
Agam\AgaP_AGAP005873
12 of 12
Yes
Yes
Arabidopsis thaliana (thale-cress) (3)
Atha\NRPB6A
12 of 13
Yes
Yes
Atha\NRPB6B
12 of 13
Yes
Yes
Atha\AT1G53210
1 of 13
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\RPO26
11 of 13
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\rpb6
10 of 12
Yes
Yes
Escherichia coli (enterobacterium) (1)
Ecol\rpoZ
1 of 11
Yes
Yes
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Polr2F. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    POLR2F; RNA polymerase II, I and III subunit F
    14 of 14
    604414
         
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Show neighbor-neighbor interactions:
        Show/hide secondary interactors 
        (data from AllianceMine provided by esyN)
        Select Layout:
        Legend:
        Protein
        RNA
        Selected Interactor(s)
        Other Interaction Browsers
        View in FlyBase Interactions Browser   View in MIST tool (external link)
        Please see the Physical Interaction reports below for full details
        protein-protein
        Physical Interaction
        Assay
        References
        Polr2F - CG8117
        anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
        (Rhee et al., 2014)
        Polr2F - Polr2A
        anti bait coimmunoprecipitation, molecular weight estimation by staining
        (Dollinger et al., 2023)
        Summary of Genetic Interactions
        esyN Network Diagram
        Other Interaction Browsers
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Subunit Structure (UniProtKB)
        Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.
        (UniProt, Q24320 )
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Class of Gene
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        3R
        Recombination map
        3-47.5
        Cytogenetic map
        83A1-83A1
        Sequence location
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        83A1-83A1
        Limits computationally determined from genome sequence between P{PZ}l(3)0273302733 and P{EP}EP974
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        83A-83A
        (determined by in situ hybridisation)
        (Hamilton et al., 1993, Hamilton, 1990)
        Experimentally Determined Recombination Data
        Location

        3-47.5

        (FlyBase, 2016)

        3-44.1

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (4)
        Genomic Clones (16)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (46)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          Antibody Information
          Laboratory Generated Antibodies
           
          Commercially Available Antibodies
           
          Cell Line Information
          Publicly Available Cell Lines
           
            Other Stable Cell Lines
             
              Other Comments

              DNA-protein interactions: genome-wide binding profile assayed for RpII18 protein in Kc167 cells; see Chromatin_types_NKI collection report. Individual protein-binding experiments listed under "Samples" at GEO_GSE22069 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE22069).

              (Filion et al., 2010)

              RNAi screen using dsRNA made from templates generated with primers directed against this gene results in aberrantly long spindles with misaligned chromosomes when assayed in S2 cells in the presence of Cdc27 dsRNA. This phenotype cannot be observed when the screen is performed without Cdc27 dsRNA.

              (Goshima et al., 2007)

              Used in a phylogenetic analysis, the tree in inferred by parsimony method from RpoB sequences, or homologous, multiple alignment.

              (Mollet et al., 1998)

              Isolated from a D.melanogaster embryonic cDNA library using human Hs6 (hRPB14.4) cDNA as a probe.

              (Shpakovski et al., 1995)

              RpII18 cDNA has been cloned and sequenced.

              (Shpakovski et al., 1995)

              The technique of paramagnetic particle-mediated selection of terminated run-on transcripts was used to examine RNA polymerase II pausing and 5' cap formation at high resolution on the heat shock genes Hsp70A, Hsp70B, Hsp26 and Hsp27. Results demonstrate that polymerases pause over a narrow region of each heat shock gene, not at a defined point. 5' capping occurs over a region coincidental with that of pausing.

              (Rasmussen and Lis, 1993)

              Protein complexes of RNA polymerase II localise to major developmental puffs and heat shock puffs.

              (Weeks et al., 1993)
              Relationship to Other Genes
              Source for database merge of

              Source for merge of: RpII18 RpABC14

              (Aoyagi and Wassarman, 2000)

              Source for merge of: RpII18 BcDNA:RH21608

              (FlyBase, 1996-)
              Additional comments

              Source for merge of RpII18 BcDNA:RH21608 was a shared cDNA ( date:030728 ).

              (FlyBase, 1996-)
              Nomenclature History
              Source for database identify of

              Source for identity of: RpABC14 CG1163

              (Guan, 1999.11)

              Source for identity of: Polr2F RpII18

              (Marygold et al., 2020)
              Nomenclature comments
              Etymology

              Named 'Polr2F' after the human ortholog.

              (Marygold et al., 2020)
              Synonyms and Secondary IDs (29)
              Reported As
              Symbol Synonym
              BcDNA:RH21608
              CG1163
              (Marygold et al., 2020, Schertel et al., 2013, Keleman et al., 2009.8.5, Weber et al., 2008, Goshima et al., 2007, Aoyagi and Wassarman, 2000)
              Dm6
              (Shpakovski et al., 1995)
              H5
              (Leatherman et al., 2002, Robertson et al., 1999)
              Pol II
              (Vorobyeva et al., 2011, Hendrix et al., 2008, Moorman et al., 2006, Moorman et al., 2006, Kim et al., 2004, Boehm et al., 2003, Armstrong et al., 2002)
              PolII
              (Yamada et al., 2020, Shao and Zeitlinger, 2017, Chen et al., 2008, Piel et al., 2008, Zhang et al., 2004)
              Polr2F
              (Marygold et al., 2020)
              RNA Pol II
              (Blythe and Wieschaus, 2015, Mito et al., 2005, Meehan et al., 2001)
              RNA pol II
              (Gilfillan et al., 2006, Farkas et al., 2000)
              RNA polII
              (Leclerc et al., 2000)
              RNA polymerase II
              (Ulianov et al., 2016)
              RNAP
              (Ma, 2005)
              RNAP II
              (Leatherman and Jongens, 2003, Mollet et al., 1998, Seydoux and Dunn, 1997)
              RNApolII
              (Sauer et al., 1995, Sauer et al., 1995)
              RPB6
              (Marygold et al., 2020)
              RPB6_DROME
              (Storm and Sonnhammer, 2003)
              RPII18
              (Kondo and Perrimon, 2011, Filion et al., 2010)
              RPO26
              (Marygold et al., 2020)
              RpABC14
              RpII18
              (Schertel et al., 2013, Japanese National Institute of Genetics, 2012.5.21, White et al., 2011, Swaminathan et al., 2010, Goshima et al., 2007)
              Rpb6
              (Dollinger et al., 2023)
              Rpll18
              (Weber et al., 2008)
              pol II
              (Zhang and Gilmour, 2006)
              polII
              (Gu et al., 2002, Bentley, 1998, Lis, 1998)
              rpII18
              (Zaytseva et al., 2023)
              Name Synonyms
              RNA polymerase II
              (Zhao et al., 2020, Ratnaparkhi and Courey, 2008, Silverman et al., 2008, Redhouse and White, 2007, Yao et al., 2006, Heinkoff et al., 2004, Shore et al., 2003, Chao and Price, 2001, Mahowald, 2001, Mizuguchi et al., 2001, Morcillo and MacIntyre, 2001, Chao et al., 2000, Kal et al., 2000, Pham et al., 1999, Reim et al., 1999, Robertson et al., 1999, Schock et al., 1999, Bentley, 1998, Gu, 1998, Peng et al., 1998, Peng et al., 1998, Sandaltzopoulos and Becker, 1998, Hansen et al., 1997, Kephart et al., 1992, Visa et al., 1991, Spencer and Groudine, 1990, Wampler et al., 1990, Visa et al., 1988)
              RNA polymerase II (18-kDa subunit)
              (Moorman et al., 2006)
              RNA polymerase II 18kD subunit
              (Swaminathan et al., 2010)
              RNA polymerase II, I and III subunit F
              RNA-polymerase ABC 14kD subunit
              Secondary FlyBase IDs
              • FBgn0014025
              • FBgn0064834
              Datasets (1)
              Study focus (1)
              Experimental Role
              Project
              Project Type
              Title
              • transgene_used
              FBGSE22069
              Protein profiling reveals five principal chromatin types in Drosophila cells.
              Study result (0)
              Result
              Result Type
              Title
              External Crossreferences and Linkouts ( 60 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
              UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
              Other crossreferences
              AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
              DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
              EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
              FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
              FlyMine - An integrated database for Drosophila genomics
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              MARRVEL_MODEL - MARRVEL (model organism gene)
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              Flygut - An atlas of the Drosophila adult midgut
              FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              References (110)