Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Rsp using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Rsp in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
All naturally occurring SD chromosomes carry RanGapSD and Rspi. Typical SD+ chromosomes carry Rsps and its presence is sufficient to render a chromosome sensitive to the action of RanGapSD. Some SD+ chromosomes carry Rspi. To cause high levels of distortion, RanGapSD requires the presence of a series of upward modifiers known as E(SD)unspecified, St-SDunspecified and M(Sd)unspecified.
Analysis of the large scale molecular structure of Rsp reveals that Rsp repeats isolated from one chromosome are not more similar than those from a different chromosome, the repeats usually have a dimeric structure and frequent unequal crossover events can obscure the phylogenetic relationships between repeats.
Structural role of Rsp is determined by preferentially perturbing the locus using Hoechest 33258.
Rsp is the target for the action of RanGapSD and can exist in a sensitive or insensitive state. E(SD)unspecified distortion is mediated via Rsp, whether Rsp is on the Y or second chromosome. E(SD)unspecified is independently capable of acting on Rsp and is not a simple modifier of RanGapSD.
A possible relationship between the SD system of segregation distortion and the P, I and hobo transposable element systems has been suggested.
Rsp is the most proximal known locus within the 2R heterochromatin: determined by free duplications for the centromeric region of the second chromosome and their sensitivity to distortion.
Rsp has been mapped as the most proximal locus in 2R heterochromatin by cytology and lethal complementation tests of autosomal insertions into the long arm of the Y chromosome. This suggests that Rsp is separable from the second chromosome centromere and its behaviour does not depend on gross chromosomal position.
Spontaneous and radiation-induced recombination analyses and deficiency studies of the SD-5 chromosome provide evidence that the Rsp locus lies within the proximal heterochromatin of the right arm of chromosome 2.
To investigate how SD behaves and is maintained in nature the major components of the SD system have been examined in two natural populations.