General Information
Symbol
Dmel\Rsp
Species
D. melanogaster
Name
Responder to Sd
Annotation Symbol
Feature Type
FlyBase ID
FBgn0003284
Gene Model Status
Stock Availability
GO Summary Ribbons
Families, Domains and Molecular Function
Gene Group Membership (FlyBase)
Protein Family (UniProt, Sequence Similarities)
-
Protein Domains/Motifs
Molecular Function (see GO section for details)
Experimental Evidence
-
Predictions / Assertions
-
Summaries
Phenotypic Description from the Red Book (Lindsley and Zimm 1992)
Rsp: Responder
The region of the chromosome upon which Sd acts to cause dysfunction of sperm that receive it; the sensitivity of Rsp is unaffected by its position in the genome, being equally responsive to Sd either in repulsion or coupling with Sd, or when located ectopically as in Dp(2;f)Rsp (Brittnacher and Ganetzky, 1989, Genetics 121: 739-50) or in Dp(2;Y)Rsp (Lyttle and Ault, 1985, Genetics 110: s23; Lyttle, 1989, Genetics 121: 751-63).
Gene Model and Products
Number of Transcripts
0
Number of Unique Polypeptides
0

Please see the GBrowse view of Dmel\Rsp or the JBrowse view of Dmel\Rsp for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Polypeptides with Identical Sequences

 

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Rsp using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Gene Ontology (0 terms)
Molecular Function (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Rsp in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Alleles, Insertions, Transgenic Constructs and Phenotypes
Classical and Insertion Alleles ( 16 )
For All Classical and Insertion Alleles Show
 
Allele of Rsp
Class
Mutagen
Associated Insertion
Stocks
Known lesion
    0
    --
    Other relevant insertions
    Transgenic Constructs ( 0 )
    For All Alleles Carried on Transgenic Constructs Show
    Transgenic constructs containing/affecting coding region of Rsp
    Allele of Rsp
    Mutagen
    Associated Transgenic Construct
    Stocks
    Transgenic constructs containing regulatory region of Rsp
    Deletions and Duplications ( 22 )
    Summary of Phenotypes
    For more details about a specific phenotype click on the relevant allele symbol.
    Lethality
    Allele
    Sterility
    Allele
    Phenotype manifest in
    Allele
    Orthologs
    Human Orthologs (via DIOPT v7.1)
    Homo sapiens (Human) (0)
    No orthologs reported.
    Model Organism Orthologs (via DIOPT v7.1)
    Mus musculus (laboratory mouse) (0)
    No orthologs reported.
    Rattus norvegicus (Norway rat) (0)
    No orthologs reported.
    Xenopus tropicalis (Western clawed frog) (0)
    No orthologs reported.
    Danio rerio (Zebrafish) (0)
    No orthologs reported.
    Caenorhabditis elegans (Nematode, roundworm) (0)
    No orthologs reported.
    Arabidopsis thaliana (thale-cress) (0)
    No orthologs reported.
    Saccharomyces cerevisiae (Brewer's yeast) (0)
    No orthologs reported.
    Schizosaccharomyces pombe (Fission yeast) (0)
    No orthologs reported.
    Orthologs in Drosophila Species (via OrthoDB v9.1) ( None identified )
    No orthologies identified
    Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( None identified )
    No non-Drosophilid orthologies identified
    Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( None identified )
    No non-Dipteran orthologies identified
    Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( None identified )
    No non-Insect Arthropod orthologies identified
    Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
    No non-Arthropod Metazoa orthologies identified
    Human Disease Model Data
    FlyBase Human Disease Model Reports
      Alleles Reported to Model Human Disease (Disease Ontology)
      Download
      Models ( 0 )
      Allele
      Disease
      Evidence
      References
      Interactions ( 0 )
      Allele
      Disease
      Interaction
      References
      Comments ( 0 )
       
      Human Orthologs (via DIOPT v7.1)
      Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
      Homo sapiens (Human)
      Gene name
      Score
      OMIM
      OMIM Phenotype
      Complementation?
      Transgene?
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      esyN Network Diagram
      Interactions Browser
      Summary of Genetic Interactions
      esyN Network Diagram
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      External Data
      Linkouts
      DroID - A comprehensive database of gene and protein interactions.
      Pathways
      Gene Group - Pathway Membership (FlyBase)
      External Data
      Linkouts
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      Recombination map
      2-56.61
      Cytogenetic map
      Sequence location
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      h38-h38
      Left limit from inclusion within Tp(2;Y)cb25-24 (FBrf0049925) Right limit from inclusion within Tp(2;Y)cb25-24 (FBrf0049925)
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      Experimentally Determined Recombination Data
      Location
      2-56.61
      Right of (cM)
      Notes
      Mapping based on 122 pr-cn recombinants.
      Stocks and Reagents
      Stocks (13)
      Genomic Clones (0)
       
        cDNA Clones (0)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequences
        BDGP DGC clones
          Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
                Other clones
                  RNAi and Array Information
                  Linkouts
                  Antibody Information
                  Laboratory Generated Antibodies
                   
                  Commercially Available Antibodies
                   
                  Other Information
                  Relationship to Other Genes
                  Source for database identify of
                  Source for database merge of
                  Additional comments
                  Other Comments
                  All naturally occurring SD chromosomes carry RanGapSD and Rspi. Typical SD+ chromosomes carry Rsps and its presence is sufficient to render a chromosome sensitive to the action of RanGapSD. Some SD+ chromosomes carry Rspi. To cause high levels of distortion, RanGapSD requires the presence of a series of upward modifiers known as E(SD)unspecified, St-SDunspecified and M(Sd)unspecified.
                  Analysis of the large scale molecular structure of Rsp reveals that Rsp repeats isolated from one chromosome are not more similar than those from a different chromosome, the repeats usually have a dimeric structure and frequent unequal crossover events can obscure the phylogenetic relationships between repeats.
                  The recessive semi-lethality caused by Df(2R)Rsp16, and previously suggested to be due to the deletion of Rsp, may actually be at least partly due to the deletion of closely linked Bari1.
                  Structural role of Rsp is determined by preferentially perturbing the locus using Hoechest 33258.
                  Rsp is the target for the action of RanGapSD and can exist in a sensitive or insensitive state. E(SD)unspecified distortion is mediated via Rsp, whether Rsp is on the Y or second chromosome. E(SD)unspecified is independently capable of acting on Rsp and is not a simple modifier of RanGapSD.
                  A possible relationship between the SD system of segregation distortion and the P, I and hobo transposable element systems has been suggested.
                  Rsp is the most proximal known locus within the 2R heterochromatin: determined by free duplications for the centromeric region of the second chromosome and their sensitivity to distortion.
                  Rsp has been mapped as the most proximal locus in 2R heterochromatin by cytology and lethal complementation tests of autosomal insertions into the long arm of the Y chromosome. This suggests that Rsp is separable from the second chromosome centromere and its behaviour does not depend on gross chromosomal position.
                  The sensitivity of Rsp to RanGapSD depends on the size of the h39 band: this demonstrates that the Rsp locus is composed of repeated DNA.
                  In flies without SD, deletion of the Rsp region results in flies (both male and female) that are less fit than Rsp+ flies.
                  Dp(2;Y)Sd causes dysfunction of Rsps bearing sperm indicating that Rsp activity does not depend on pairing with a normal autosomal homologue.
                  Spontaneous and radiation-induced recombination analyses and deficiency studies of the SD-5 chromosome provide evidence that the Rsp locus lies within the proximal heterochromatin of the right arm of chromosome 2.
                  To investigate how SD behaves and is maintained in nature the major components of the SD system have been examined in two natural populations.
                  Origin and Etymology
                  Discoverer
                  Etymology
                  Identification
                  External Crossreferences and Linkouts ( 9 )
                  Crossreferences
                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                  Linkouts
                  DroID - A comprehensive database of gene and protein interactions.
                  Synonyms and Secondary IDs (11)
                  Datasets (0)
                  Study focus (0)
                  Experimental Role
                  Project
                  Project Type
                  Title
                  References (94)