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General Information
Symbol
Dmel\rst
Species
D. melanogaster
Name
roughest
Annotation Symbol
CG4125
Feature Type
FlyBase ID
FBgn0003285
Gene Model Status
Stock Availability
Gene Snapshot
roughest (rst) encodes a multi-purpose transmembrane protein that is well studied in the fly eye and muscle during development. It interacts with the transmembrane ligand encoded by hbs to guide cell movement. [Date last reviewed: 2019-03-14]
Also Known As
irreC, irreC-rst, rst-irreC, irreC-roughest, irregular chiasm C-roughest
Key Links
Genomic Location
Cytogenetic map
Sequence location
X:2,950,399..2,973,834 [-]
Recombination map
1-2
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Protein Family (UniProt)
-
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
Predictions / Assertions
-
Summaries
Protein Function (UniProtKB)
Required for correct axonal pathway formation in the optic lobe and for programmed cell death in the developing retina.
(UniProt, Q08180)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
irreC: irregular chiasm-C (J.C. Hall)
In optic ganglia, fiber tracts from the medulla to the lobula plate penetrate lobula neuropile instead of projecting through second optic chiasm; occasionally, ectopic bundles of axonal fibers penetrate lobula-plate neuropile; in most severely deformed individuals, lobula and lobula plate are partly fused. In first optic chiasm, fibers from lamina are misrouted, taking detour around posterior medulla neuropile, penetrating the latter at variable positions on its inner (posterior) face from which positions the fiber tracts turn around and form normal-appearing terminals in retinotopic locations. Gynandromorph analysis showed that eye genotype does not induce optic lobe phenotypes. It also appears as if first- (or second-) chiasm defect does not induce that in the second (or first); among several mutant individuals analyzed (cf. variable expressivity under alleles), there is no correlation between the anatomical abnormalities in these two locations (though there is high correlation between defective first or second chiasm in left and right sides of head). Optic lobe pioneer axons [larval neurons, which persist into adulthood and can be seen following path of first optic chiasm, and may guide newly growing fibers during formation of imaginal visual system (Tix, Minden, and Technau, 1989, Development 105: 739-46)] are displaced in irreC pupae, with their axons having followed ectopic pathways.
rst: roughest
Eyes rough and bulging; facets irregular in size and arrangement.
UB883
Eye mutant. Inner optic chiasma in disorder. Bundles of fibers connecting medulla and lobula plate penetrate neuropil of lobula.
Summary (Interactive Fly)
Ig-C2-type-domain protein - transmembrane - required in at least three independent events in eye development and axon guidance - The adhesion molecules Roughest, Hibris, Kin of Irre and Sticks and Stones are required for long range spacing of the Drosophila wing disc sensory sensilla
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\rst or the JBrowse view of Dmel\rst for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.45
Gene model reviewed during 5.52
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0070562
4818
764
FBtr0343758
6251
764
Additional Transcript Data and Comments
Reported size (kB)
5 (northern blot)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0070537
83.0
764
6.99
FBpp0310320
83.0
764
6.99
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

764 aa isoforms: rst-PA, rst-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
764 (aa); 83 (kD predicted)
Comments
External Data
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\rst using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (13 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
inferred from physical interaction with FLYBASE:X11L; FB:FBgn0026313
Terms Based on Predictions or Assertions (0 terms)
Biological Process (7 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
Cellular Component (5 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from sequence or structural similarity
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
dorsal ectoderm anlage

Comment: anlage in statu nascendi

ventral ectoderm anlage

Comment: anlage in statu nascendi

antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

antennal anlage

Comment: reported as procephalic ectoderm anlage

central brain anlage

Comment: reported as procephalic ectoderm anlage

dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

visual anlage

Comment: reported as procephalic ectoderm anlage

ventral nerve cord primordium

Comment: reported as ventral nerve cord anlage

organism | dorsal | restricted

Comment: dorsal midline; expression fades at stage 12

cell of mesoderm

Comment: expression in majority of mesodermal cells

RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
rst mRNA is first detected at low levels in early pupae, peaks at 24% APF and then returns to basal levels by 43% APF.
rst transcripts are found predominantly within the interommatidial cell at 24 hours APF.
rst transcript is expressed from embryonic stage 4-14. Embryonic stage 4 expression is initially in a pattern of seven stripes, which soon fades. Subsequently, rst is expressed in dorsally in the procephalic region and in the amnioserosa anlage. At stage 8, rst is expressed in mesectodermal cells in a segmental pattern. At stage 9, rst is expressed at the dorsal midline and in mesodermal cells. Dorsal midline expression intensifies during stage 10-11, as expression begins in visceral muscle progenitors. At stage 12, rst has strong expression in most mesodermal cells as dorsal midline expression fades. At stages 13-14, expression is in muscle founder cells, and in fusion-competent myoblasts.
rst transcripts are expressed throughout development with peaks in embryonic and pupal stages. In late stage 11 embryos, transcripts are detected in lateral mesodermal cell clusters, in the midline, in cell clusters in the mandibular, maxillary, and labial buds, and in the clypeolabrum. In late third instar larvae, strong signal is observed in the imaginal discs and in the outer optic anlagen. In the eye disc, expression starts just in front of the morphogenetic furrow. In pupae, expression is observed in the lamina and in subpopulations of medullar cells. At 36hr, retinal expression is restricted to cells between the ommatidiial clusters (ie. to presumptive secondary and tertiary pigment cells and to cells of the bristle complex). Expression is then down-regulated in the retina and transcripts can no longer be detected 72hr after puparium formation.
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
distribution deduced from reporter
Stage
Tissue/Position (including subcellular localization)
Reference
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
rst and rst are observed primarily in interommatidial cells in a pattern complementary to sns and hbs.
In late third instar larvae salivary glands, strong rst immunoreactivity is observed at cell boundaries and in an internal lace-like pattern that appears to show colocalization with tubulin. No expression is observed in the luminal region of the gland. A few hours later, no staining is seen and then signal is observed again at 3 hours APF but in a reorganized intracellular pattern. Expression persists until 10 hours APF.
rst exhibits dynamic expression from larval through pupal development. High levels are seen at the border between two primary pigment cells and between neighboring interommatidial cells in pupal cells from 24-42 hours APF.
rst protein is localised along the border between secondary and tertiary pigment cells,
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\rst in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 23 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 12 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of rst
Transgenic constructs containing regulatory region of rst
Deletions and Duplications ( 98 )
Disrupted in
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
thorax & microchaeta
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (11)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
12 of 15
Yes
Yes
11 of 15
No
Yes
10 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
 
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (10)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
12 of 15
Yes
Yes
 
11 of 15
No
Yes
 
10 of 15
No
Yes
 
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
Rattus norvegicus (Norway rat) (7)
12 of 13
Yes
Yes
10 of 13
No
Yes
7 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (7)
9 of 12
Yes
Yes
2 of 12
No
Yes
1 of 12
No
No
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
No
1 of 12
No
No
Danio rerio (Zebrafish) (22)
13 of 15
Yes
Yes
12 of 15
No
Yes
11 of 15
No
Yes
7 of 15
No
Yes
5 of 15
No
Yes
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (6)
8 of 15
Yes
Yes
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190425 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501IG )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W04IX )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bombyx mori
Silkmoth
Bombyx mori
Silkmoth
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Danaus plexippus
Monarch butterfly
Danaus plexippus
Monarch butterfly
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Heliconius melpomene
Postman butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X08BT )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (38)
6 of 10
3 of 10
3 of 10
2 of 10
2 of 10
2 of 10
2 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Gene Group - Pathway Membership (FlyBase)
    External Data
    Linkouts
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    X
    Recombination map
    1-2
    Cytogenetic map
    Sequence location
    X:2,950,399..2,973,834 [-]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    3C3-3C4
    Limits computationally determined from genome sequence between P{EP}EP1362 and P{EP}dncEP1395
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    3C5-3C5
    (determined by in situ hybridisation)
    Experimentally Determined Recombination Data
    Notes
    Mapping based on 132 w-Nspl-1 recombinants.
    Stocks and Reagents
    Stocks (19)
    Genomic Clones (12)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (99)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
     
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for identity of: rst CG4125
    Source for database merge of
    Source for merge of: rst UB883
    Additional comments
    Other Comments
    rst is required for differentiation and time of death of interommatidial cells during pupal stages of compound eye development.
    rst and kirre act redundantly during muscle development as myoblast attractants.
    Loss of function and misexpression of rst results in an altered arrangement of sensory organ founder cells within the antennal disc.
    Amorphic mutations of z are strong recessive enhancers of position effect variegation (PEV) for the w, rst and N loci.
    Restricted expression of the rst protein is required for normal axonal projections of columnar visual neurons.
    rst gene product is required for the normal number of cell deaths in the eye imaginal discs.
    Eyes rough and bulging; facets irregular in size and arrangement. In optic ganglia, fiber tracts from the medulla to the lobula plate penetrate lobula neuropil instead of projecting through second optic chiasm; occasionally, ectopic bundles of axonal fibers penetrate lobula-plate neuropil; in most severely deformed individuals, lobula and lobula plate are partly fused. In first optic chiasm, fibers from lamina are misrouted, taking detour around posterior medulla neuropil, penetrating the latter at variable positions on its inner (posterior) face from which positions the fiber tracts turn around and form normal-appearing terminals in retinotopic locations. Gynandromorph analysis showed that eye genotype does not induce optic lobe phenotypes. It also appears as if first- (or second-) chiasm defect does not induce that in the second (or first); among several mutant individuals analyzed, there is no correlation between the anatomical abnormalities in these two locations (though there is high correlation between defective first or second chiasm in left and right sides of head). Optic lobe pioneer axons <up>larval neurons, which persist into adulthood and can be seen following path of first optic chiasm and may guide newly growing fibers during formation of imaginal visual system</up> are displaced in rst pupae, with their axons having followed ectopic pathways.
    rst is required for normal elimination of surplus cells from the retinal epithelium. Cell death eliminates 2 or 3 cells per ommatidium 35 and 50 hours after pupation.
    rst is necessary for the correct projection of visual fibres in the optic chiasms of optic ganglia.
    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 128 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
    KEGG Genes - Molecular building blocks of life in the genomic space.
    modMine - A data warehouse for the modENCODE project
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyMine - An integrated database for Drosophila genomics
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    Synonyms and Secondary IDs (32)
    Reported As
    Symbol Synonym
    IrreC-Rst
    UB883
    Secondary FlyBase IDs
    • FBgn0001272
    • FBgn0005381
    Datasets (0)
    Study focus (0)
    Experimental Role
    Project
    Project Type
    Title
    References (285)