novel regulator of cell cycle - a cyclin dependent kinase inhibitor that specifically inhibits Cdk1-CycA - required to inhibit Cdk1-CycA kinase activity during metaphase, thereby facilitating the transition to anaphase
Gene model reviewed during 5.46
Low-frequency RNA-Seq exon junction(s) not annotated.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\rux using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\rux in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: rux CG4336
Shows particularly robust cycling of transcription in adult heads, as assessed by expression analysis using high density oligonucleotide arrays with probe generated during three 12-point time course experiments over the course of 6 days.
rux is a cyclin dependent kinase inhibitor (CKI) specific for mitotic cyclin-cdk complexes.
In vitro studies demonstrate rux binds CycE but does not inhibit CycE-Cdk activity directly. Overexpression studies suggest the ectopic rux converts the mitotic cycle into an endoreplication cycle by down-regulating CycA-associated kinase activity.
The rux mutant phenotype is due to a developmental defect: pattern formation defect.