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Gene Dmel\S

General Information
Symbol	Dmel\S	Species	D. melanogaster
Name	Star	Annotation symbol	CG4385
Feature type	protein_coding_gene	FlyBase ID	FBgn0003310
Gene Model Status	Current	Stock availability	101 publicly available
Also Known As	star, Star/asteroid
Genomic Location
Chromosome (arm)	2L	Recombination map	2-1.3
Cytogenetic map	21E4-21E4	Sequence location	2L:1,050,877..1,077,811 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Star is referred to in FlyBase by the symbol Dmel\S (CG4385, FBgn0003310). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: stomatogastric nervous system development; determination of genital disc primordium; protein targeting to Golgi; compound eye retinal cell programmed cell death; regulation of epidermal growth factor receptor signaling pathway; ommatidial rotation; epidermal growth factor receptor ligand maturation; imaginal disc-derived wing morphogenesis; behavioral response to ethanol. 152 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; adult segment; nervous system; external compound sense organ; embryonic/larval neuron; peripheral nervous system; adult mesothoracic segment; female germline cyst; commissure; multi-cell-component structure. It has 2 annotated transcripts and 2 annotated polypeptides. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1638189_s_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of S. Gene sequence location is 2L:1050877..1077811.
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	S: Star Eyes slightly smaller and narrower than wild type; texture somewhat rough from rounded, irregular facets. Arrangement of hairs on surface of eye irregular. S/ast has small rough eyes; S ast/+ + is like S/+. Enhanced by E(S); partially suppresses px and net (Bedichek, 1936, DIS 5: 24; Lewis, 1945). Homozygote dies in late embryonic stage (Sivertzev-Dobzhansky, 1927, Wilhelm Roux's Arch. Entwicklungsmech. Organ. 109: 535-48; Sonnenblick and Huettner, 1938, Genetics 23: 169). A member of the so-called spitz group of mutants; embryos lack structures derived from ventral-lateral region of blastoderm. Denticle bands narrow and ventral arms of head skeleton fused. Anal pads reduced. Transverse commisures of ventral nervous system reduced; Keilin organs, maxillary and antennal sense organs strongly reduced. Lethal in homozygous clones in female germ line (Nusslein-Volhard, Wieschaus, and Kluding, 1984, Wilhelm Roux's Arch. Dev. Biol. 193: 267-82; Mayer and Nusslein-Volhard). RK1.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Controlled Vocabulary Terms precursor cell of the stomatogastric nervous system embryonic stage 10 References Rousso et al., 2010, Development 137(20): 3427--3437 Sequence features HFA00785 BKN30371
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 21E4-21E4   Limits computationally determined from genome sequence between P{lacW}l(2)k09610k09610&P{lacW}Sk09538a and P{PZ}l(2)1068510685&P{lacW}Tango14k00619
Experimentally Determined Cytological Location
Cytogenetic map Notes References 21E2-21E2     (Prokopenko, 1999.8.3) 21D2-21D3   (determined by in situ hybridisation)   (Spradling et al., 1999) 21E1-21E2   (determined by in situ hybridisation)   (Forjanic et al., 1997) 21E-21F   (determined by in situ hybridisation)   (Kania et al., 1995) 21E1-21E2   (determined by in situ hybridisation)   (Kotarski et al., 1991) 21C6-21C7   21E1--2 21E1--3 21E2--3 21E3--4   (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location	2-1.3 (Reuter and Szidonya, 1983, Tearle and Nusslein-Volhard, 1987, Waletzky, 1939) 2- (Neufeld et al., 1998)
Left of (cM)	ast (Lewis, 1945)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\S for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) S-RA FBtr0077994  NM_164403   3182   597 S-RB FBtr0077993  NM_078726   3999   597
Additional Transcript Data & Comments
Reported size (kB)	4.0 (northern blot) (Kolodkin et al., 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein S-PA   FBpp0077659   65.8   597   7.98     NP_722674   AAF51425 S-PB   FBpp0077658   65.8   597   7.98     NP_523450   AAN10478
Additional Polypeptide Data & Comments
Reported size (kDa)	597 (aa); 66 (kD predicted) (Kolodkin et al., 1994)
Comments
External Data
Linkouts
Crossreferences
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA438599   AA950739   AE014134 AAF51425   AE014134 AAN10478   AF174675   AF174676   AI403375   AQ025780   AQ025896   AY113201 AAM29206   BF485912   BF495387   BF504778   BG638616   BI374709   BI375222   BI633836   BP554495   CL844419   CO187071   CO262198   CO262432   CO268587   CO276275   CO278697   CO290004   CO291340   CO295216   CO298104   CO306808   CO323596   CO342244   CZ466184   CZ472344   EC057505   EC068165   EC081862   EC081863   EC082507   EC085356   EC087738   EC195168   EC196369   EC196582   EC198182   EC202511   EC220249   EC220368   EC226082   EC233201   EC235117   EC236118   EC254812   G00465   GH748163   GH751980   GH754769   GH759561   GH770193   GH782314   GH793193   GH804284   GH804831   GH815552   GH821570   GH822736   GH824326   GH831168   GH833457   GH834785   GH836780   GH837738   GH838150   GH839023   GH846439   GH847483   GH848548   GH849436   GH852244   GH854518   GH854599   GH855478   GH855656   GH856221   GH860877   GH864053   GH864210   GH867540   GH868448   GH874636   GH875747   GH884747   GH893565   GH894893   GH897696   GH902090   GH902763   GH907259   GH908902   GH919457   GH920050   GH923317   GH924351   GH924781   GH933206   GH935410   L31886 AAB04161   Z31977   Z32315
UniProtKB/Swiss-Prot	P42519
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   embryonic optic lobe primordium   (Kolodkin et al., 1994) mesectoderm   (Kolodkin et al., 1994) midline glial cell   (Kolodkin et al., 1994) embryonic stage 10   precursor cell of the stomatogastric nervous system   (Gonzalez-Gaitan and Jackle, 2000) third instar larval stage   photoreceptor cell R5 | presumptive   (Kolodkin et al., 1994) photoreceptor cell R8 | presumptive   (Kolodkin et al., 1994) eye-antennal disc   (Kolodkin et al., 1994) photoreceptor cell R2 | presumptive   (Kolodkin et al., 1994) morphogenetic furrow   (Kolodkin et al., 1994)
Additional Descriptive Data
	S transcripts are expressed throughout embryonic development. S transcripts are initially detected at ~stage 4 in a ventrolateral domain 7-9 cells wide. As gastrulation proceeds, the expression domain moves ventrally and is located in a 5-7 cell wide band on either side of the ventral midline. By stage 8 a single band 2-4 cells wide is stained along the midline and by stage 9,10, expression is refined to a single band of cells 1-2 cells wide that corresponds to the mesectoderm. The midline expression is further refined to small clusters of cells that are thought to be midline glia. Expression is also observed in ventrolateral stripes and in the optic lobe anlage. In the eye disc, S transcripts are observed at the morphogenetic furrow in a narrow band that is only one cluster wide. Immediately posterior to the furrow, the level of S transcripts drops dramatically for three to four columns before being expressed again at high levels in the developing photoreceptor cell clusters. Initially, the transcript is expressed strongly in three cells that are likely to be R2, R5, and R8. Later, other photoreceptor cells also express S. (Kolodkin et al., 1994)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0003310    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0003310 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0003310 expression level Developmental Stage   Expression Level embryo 00-02hr    4639 embryo 02-04hr    3353 embryo 04-06hr    6078 embryo 06-08hr    5221 embryo 08-10hr    4130 embryo 10-12hr    2259 embryo 12-14hr    1932 embryo 14-16hr    1630 embryo 16-18hr    1019 embryo 18-20hr    820 embryo 20-22hr    717 embryo 22-24hr    757 larva L1    584 larva L2    365 larva L3 12hr old    267 larva L3 puffstage 1-2    320 larva L3 puffstage 3-6    701 larva L3 puffstage 7-9    798 white prepupae new    833 white prepupae 12hr    1183 white prepupae 24hr    1374 pupae 2d postWPP    1085 pupae 3d postWPP    696 pupae 4d postWPP    775 adult male 01day    671 adult male 05day    846 adult male 30day    954 adult female 01day    2128 adult female 05day    2814 adult female 30day    2829 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4639) embryo 02-04hr  (3353) embryo 04-06hr  (6078) embryo 06-08hr  (5221) embryo 08-10hr  (4130) embryo 10-12hr  (2259) embryo 12-14hr  (1932) embryo 14-16hr  (1630) embryo 16-18hr  (1019) embryo 18-20hr  (820) embryo 20-22hr  (717) embryo 22-24hr  (757) larva L1  (584) larva L2  (365) larva L3 12hr old  (267) larva L3 puffstage 1-2  (320) larva L3 puffstage 3-6  (701) larva L3 puffstage 7-9  (798) white prepupae new  (833) white prepupae 12hr  (1183) white prepupae 24hr  (1374) pupae 2d postWPP  (1085) pupae 3d postWPP  (696) pupae 4d postWPP  (775) adult male 01day  (671) adult male 05day  (846) adult male 30day  (954) adult female 01day  (2128) adult female 05day  (2814) adult female 30day  (2829) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4639) embryo 02-04hr  (3353) embryo 04-06hr  (6078) embryo 06-08hr  (5221) embryo 08-10hr  (4130) embryo 10-12hr  (2259) embryo 12-14hr  (1932) embryo 14-16hr  (1630) embryo 16-18hr    1019 embryo 18-20hr    820 embryo 20-22hr    717 embryo 22-24hr    757 larva L1    584 larva L2    365 larva L3 12hr old    267 larva L3 puffstage 1-2    320 larva L3 puffstage 3-6    701 larva L3 puffstage 7-9    798 white prepupae new    833 white prepupae 12hr    1183 white prepupae 24hr    1374 pupae 2d postWPP    1085 pupae 3d postWPP    696 pupae 4d postWPP    775 adult male 01day    671 adult male 05day    846 adult male 30day    954 adult female 01day  (2128) adult female 05day  (2814) adult female 30day  (2829) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4639 embryo 02-04hr    3353 embryo 04-06hr    6078 embryo 06-08hr    5221 embryo 08-10hr    4130 embryo 10-12hr    2259 embryo 12-14hr    1932 embryo 14-16hr    1630 embryo 16-18hr    1019 embryo 18-20hr    820 embryo 20-22hr    717 embryo 22-24hr    757 larva L1    584 larva L2    365 larva L3 12hr old    267 larva L3 puffstage 1-2    320 larva L3 puffstage 3-6    701 larva L3 puffstage 7-9    798 white prepupae new    833 white prepupae 12hr    1183 white prepupae 24hr    1374 pupae 2d postWPP    1085 pupae 3d postWPP    696 pupae 4d postWPP    775 adult male 01day    671 adult male 05day    846 adult male 30day    954 adult female 01day    2128 adult female 05day    2814 adult female 30day    2829 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4639 embryo 02-04hr    3353 embryo 04-06hr    6078 embryo 06-08hr    5221 embryo 08-10hr    4130 embryo 10-12hr    2259 embryo 12-14hr    1932 embryo 14-16hr    1630 embryo 16-18hr    1019 embryo 18-20hr    820 embryo 20-22hr    717 embryo 22-24hr    757 larva L1    584 larva L2    365 larva L3 12hr old    267 larva L3 puffstage 1-2    320 larva L3 puffstage 3-6    701 larva L3 puffstage 7-9    798 white prepupae new    833 white prepupae 12hr    1183 white prepupae 24hr    1374 pupae 2d postWPP    1085 pupae 3d postWPP    696 pupae 4d postWPP    775 adult male 01day    671 adult male 05day    846 adult male 30day    954 adult female 01day    2128 adult female 05day    2814 adult female 30day    2829 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0003310 expression level Developmental Stage   Expression Level embryo 00-02hr    4639 embryo 02-04hr    3353 embryo 04-06hr    6078 embryo 06-08hr    5221 embryo 08-10hr    4130 embryo 10-12hr    2259 embryo 12-14hr    1932 embryo 14-16hr    1630 embryo 16-18hr    1019 embryo 18-20hr    820 embryo 20-22hr    717 embryo 22-24hr    757 larva L1    584 larva L2    365 larva L3 12hr old    267 larva L3 puffstage 1-2    320 larva L3 puffstage 3-6    701 larva L3 puffstage 7-9    798 white prepupae new    833 white prepupae 12hr    1183 white prepupae 24hr    1374 pupae 2d postWPP    1085 pupae 3d postWPP    696 pupae 4d postWPP    775 adult male 01day    671 adult male 05day    846 adult male 30day    954 adult female 01day    2128 adult female 05day    2814 adult female 30day    2829 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4639) embryo 02-04hr  (3353) embryo 04-06hr  (6078) embryo 06-08hr  (5221) embryo 08-10hr  (4130) embryo 10-12hr  (2259) embryo 12-14hr  (1932) embryo 14-16hr  (1630) embryo 16-18hr  (1019) embryo 18-20hr  (820) embryo 20-22hr  (717) embryo 22-24hr  (757) larva L1  (584) larva L2  (365) larva L3 12hr old  (267) larva L3 puffstage 1-2  (320) larva L3 puffstage 3-6  (701) larva L3 puffstage 7-9  (798) white prepupae new  (833) white prepupae 12hr  (1183) white prepupae 24hr  (1374) pupae 2d postWPP  (1085) pupae 3d postWPP  (696) pupae 4d postWPP  (775) adult male 01day  (671) adult male 05day  (846) adult male 30day  (954) adult female 01day  (2128) adult female 05day  (2814) adult female 30day  (2829) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4639) embryo 02-04hr  (3353) embryo 04-06hr  (6078) embryo 06-08hr  (5221) embryo 08-10hr  (4130) embryo 10-12hr  2259 embryo 12-14hr  1932 embryo 14-16hr  1630 embryo 16-18hr    1019 embryo 18-20hr    820 embryo 20-22hr    717 embryo 22-24hr    757 larva L1    584 larva L2    365 larva L3 12hr old    267 larva L3 puffstage 1-2    320 larva L3 puffstage 3-6    701 larva L3 puffstage 7-9    798 white prepupae new    833 white prepupae 12hr    1183 white prepupae 24hr    1374 pupae 2d postWPP    1085 pupae 3d postWPP    696 pupae 4d postWPP    775 adult male 01day    671 adult male 05day    846 adult male 30day    954 adult female 01day  2128 adult female 05day  (2814) adult female 30day  (2829) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4639 embryo 02-04hr    3353 embryo 04-06hr    6078 embryo 06-08hr    5221 embryo 08-10hr    4130 embryo 10-12hr    2259 embryo 12-14hr    1932 embryo 14-16hr    1630 embryo 16-18hr    1019 embryo 18-20hr    820 embryo 20-22hr    717 embryo 22-24hr    757 larva L1    584 larva L2    365 larva L3 12hr old    267 larva L3 puffstage 1-2    320 larva L3 puffstage 3-6    701 larva L3 puffstage 7-9    798 white prepupae new    833 white prepupae 12hr    1183 white prepupae 24hr    1374 pupae 2d postWPP    1085 pupae 3d postWPP    696 pupae 4d postWPP    775 adult male 01day    671 adult male 05day    846 adult male 30day    954 adult female 01day    2128 adult female 05day    2814 adult female 30day    2829 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4639 embryo 02-04hr    3353 embryo 04-06hr    6078 embryo 06-08hr    5221 embryo 08-10hr    4130 embryo 10-12hr    2259 embryo 12-14hr    1932 embryo 14-16hr    1630 embryo 16-18hr    1019 embryo 18-20hr    820 embryo 20-22hr    717 embryo 22-24hr    757 larva L1    584 larva L2    365 larva L3 12hr old    267 larva L3 puffstage 1-2    320 larva L3 puffstage 3-6    701 larva L3 puffstage 7-9    798 white prepupae new    833 white prepupae 12hr    1183 white prepupae 24hr    1374 pupae 2d postWPP    1085 pupae 3d postWPP    696 pupae 4d postWPP    775 adult male 01day    671 adult male 05day    846 adult male 30day    954 adult female 01day    2128 adult female 05day    2814 adult female 30day    2829 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0003310    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0003310 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0003310 expression level Tissue   Expression Level Larval Central Nervous System    152.85 Larval Midgut    34.2 Larval Hindgut    39.9 Larval Malpighian Tubules    21.5 Larval Fat Body    21.1 Larval Salivary Gland    79.5 Larval Trachea    45.575 Larval Carcass    37.425 Adult Head    54.4 Adult Eye    23.675 Adult Brain    115.1 Adult Thoracic-Abdominal Ganglion    104.3 Adult Crop    52.2 Adult Midgut    28.8 Adult Hindgut    51.1 Adult Malpighian Tubules no informative data Adult Fat Body    33.1 Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca    25.6 Adult InseminatedFemale Spermatheca    25.5 Adult Ovary    304.2 Adult Testis    5.4 Adult Male Accessory Gland    55.4 Adult Carcass    26 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    152.85 Larval Midgut    34.2 Larval Hindgut    39.9 Larval Malpighian Tubules    21.5 Larval Fat Body    21.1 Larval Salivary Gland    79.5 Larval Trachea    45.575 Larval Carcass    37.425 Adult Head    54.4 Adult Eye    23.675 Adult Brain    115.1 Adult Thoracic-Abdominal Ganglion    104.3 Adult Crop    52.2 Adult Midgut    28.8 Adult Hindgut    51.1 Adult Malpighian Tubules no informative data Adult Fat Body    33.1 Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca    25.6 Adult InseminatedFemale Spermatheca    25.5 Adult Ovary    304.2 Adult Testis    5.4 Adult Male Accessory Gland    55.4 Adult Carcass    26 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    152.85 Larval Midgut    34.2 Larval Hindgut    39.9 Larval Malpighian Tubules    21.5 Larval Fat Body    21.1 Larval Salivary Gland    79.5 Larval Trachea    45.575 Larval Carcass    37.425 Adult Head    54.4 Adult Eye    23.675 Adult Brain    115.1 Adult Thoracic-Abdominal Ganglion    104.3 Adult Crop    52.2 Adult Midgut    28.8 Adult Hindgut    51.1 Adult Malpighian Tubules no informative data Adult Fat Body    33.1 Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca    25.6 Adult InseminatedFemale Spermatheca    25.5 Adult Ovary    304.2 Adult Testis    5.4 Adult Male Accessory Gland    55.4 Adult Carcass    26 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    152.85 Larval Midgut    34.2 Larval Hindgut    39.9 Larval Malpighian Tubules    21.5 Larval Fat Body    21.1 Larval Salivary Gland    79.5 Larval Trachea    45.575 Larval Carcass    37.425 Adult Head    54.4 Adult Eye    23.675 Adult Brain    115.1 Adult Thoracic-Abdominal Ganglion    104.3 Adult Crop    52.2 Adult Midgut    28.8 Adult Hindgut    51.1 Adult Malpighian Tubules no informative data Adult Fat Body    33.1 Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca    25.6 Adult InseminatedFemale Spermatheca    25.5 Adult Ovary    304.2 Adult Testis    5.4 Adult Male Accessory Gland    55.4 Adult Carcass    26 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0003310 expression level Tissue   Expression Level Larval Central Nervous System    152.85 Larval Midgut    34.2 Larval Hindgut    39.9 Larval Malpighian Tubules    21.5 Larval Fat Body    21.1 Larval Salivary Gland    79.5 Larval Trachea    45.575 Larval Carcass    37.425 Adult Head    54.4 Adult Eye    23.675 Adult Brain    115.1 Adult Thoracic-Abdominal Ganglion    104.3 Adult Crop    52.2 Adult Midgut    28.8 Adult Hindgut    51.1 Adult Malpighian Tubules no informative data Adult Fat Body    33.1 Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca    25.6 Adult InseminatedFemale Spermatheca    25.5 Adult Ovary    304.2 Adult Testis    5.4 Adult Male Accessory Gland    55.4 Adult Carcass    26 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    152.85 Larval Midgut    34.2 Larval Hindgut    39.9 Larval Malpighian Tubules    21.5 Larval Fat Body    21.1 Larval Salivary Gland    79.5 Larval Trachea    45.575 Larval Carcass    37.425 Adult Head    54.4 Adult Eye    23.675 Adult Brain    115.1 Adult Thoracic-Abdominal Ganglion    104.3 Adult Crop    52.2 Adult Midgut    28.8 Adult Hindgut    51.1 Adult Malpighian Tubules no informative data Adult Fat Body    33.1 Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca    25.6 Adult InseminatedFemale Spermatheca    25.5 Adult Ovary    304.2 Adult Testis    5.4 Adult Male Accessory Gland    55.4 Adult Carcass    26 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    152.85 Larval Midgut    34.2 Larval Hindgut    39.9 Larval Malpighian Tubules    21.5 Larval Fat Body    21.1 Larval Salivary Gland    79.5 Larval Trachea    45.575 Larval Carcass    37.425 Adult Head    54.4 Adult Eye    23.675 Adult Brain    115.1 Adult Thoracic-Abdominal Ganglion    104.3 Adult Crop    52.2 Adult Midgut    28.8 Adult Hindgut    51.1 Adult Malpighian Tubules no informative data Adult Fat Body    33.1 Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca    25.6 Adult InseminatedFemale Spermatheca    25.5 Adult Ovary    304.2 Adult Testis    5.4 Adult Male Accessory Gland    55.4 Adult Carcass    26 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    152.85 Larval Midgut    34.2 Larval Hindgut    39.9 Larval Malpighian Tubules    21.5 Larval Fat Body    21.1 Larval Salivary Gland    79.5 Larval Trachea    45.575 Larval Carcass    37.425 Adult Head    54.4 Adult Eye    23.675 Adult Brain    115.1 Adult Thoracic-Abdominal Ganglion    104.3 Adult Crop    52.2 Adult Midgut    28.8 Adult Hindgut    51.1 Adult Malpighian Tubules no informative data Adult Fat Body    33.1 Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca    25.6 Adult InseminatedFemale Spermatheca    25.5 Adult Ovary    304.2 Adult Testis    5.4 Adult Male Accessory Gland    55.4 Adult Carcass    26 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules no informative data Adult Fat Body     Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    54.4   NA  Eye    23.675   NA  Brain    115.1   152.85  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    104.3   NA  Crop    52.2   34.2  Midgut    28.8   39.9  Hindgut    51.1   21.5  Malpighian Tubules    no informative data   21.1  Fat Body    33.1   79.5  Salivary Gland    no informative data   NA  Heart    no informative data   45.575  Trachea    NA   NA  VirginFemale Spermatheca    25.6   NA  InseminatedFemale Spermatheca    25.5   NA  Ovary    304.2   NA  Testis    5.4   NA  Male Accessory Gland    55.4   37.425  Carcass    26 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_01
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003310 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4385-RB FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for S Stages(s) 4-6 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal SrK134 lethal (with S1) SrK134 lethal (with S05671) SrK134 lethal (with S07056) SrK134 lethal (with SIIN) SrK134 lethal (with SrK134) S1 S05671 S07056 SIIN lethal | embryonic stage S1 lethal | embryonic stage | germline clone SKoj-R1 SKoj-R3 SKoj-R5 lethal | embryonic stage | maternal effect | recessive SKoj-R1 SKoj-R3 SKoj-R5 lethal | embryonic stage | recessive S126 S218 S528 S606 S05671 S7051 SF126 Sk06921 Sk09530 Sk09531 SrK134 Sunspecified SX155 lethal | recessive S1 S2J1 S51 S104E S07056 SBA651 Sc00080 Sdb123 SeAA2 SeAD7 SeAG4 SeAG5 SeAL11 SeAN5 SeAO3 SeAQ3 SeAS5 SeCJ9 SeDO3 SeE6 SeO7 SeQ10 SeT6 SeW4 Sk06101 Sk06920 Sk09312 Sk09530 Sk09534 Sk09538a Sk09541 Sk10232 Sk14005 Sk14020 Sk15907 Sk17024 SKoj-R1 SKoj-R2 SKoj-R3 SKoj-R4 SKoj-R5 SKoj-R6 SSC1 SSC2 SSC3 SSC4 SSC5 SSC6 SSC7 SSC8 SSC9 SSC10 SSC11 SSC12 SSCG1 SSCG2 SSCG3 SSCG4 SSCG5 SSCG6 SSCG7 SSCG8 SSCG9 SSCG10 SSCG11 SSCG12 SSCP1 SSCP2 SSCP3 SU132 Sunspecified viable SK Sterility Allele female fertile SKoj-R1 SKoj-R3 SKoj-R5 female sterile | dominant SKojak female sterile | recessive SKoj-R2 SKoj-R4 SKoj-R6 female sterile soma-dependent | dominant SKojak Other Phenotypes Allele cell polarity defective S48-5 S05671 chemical sensitive Sd01624 increased cell death | pupal stage P7 S48-5 neuroanatomy defective SIIN neuroanatomy defective | embryonic stage S54 visible S1 S07056 Sdb123 SL SM SW SX155 SX visible, with Scer\GAL4Bx-MS1096 SScer\UAS.cGb visible, with Scer\GAL4GMR.PF SScer\UAS.cGa visible | dominant S1 S51 S54 S104E S05671 SeAA2 SeAD7 SeAG4 SeAG5 SeAL11 SeAN5 SeAO3 SeAQ3 SeAS5 SeCJ9 SeDO3 SeE6 SeO7 SeQ10 SeT6 SeW4 Sk09530 SKojak SKoj-R4 Sunspecified wild-type, with Scer\GAL4CY2 SScer\UAS.cBa Phenotype manifest in Allele anal pad Sunspecified anterior commissure S1 cephalopharyngeal skeleton Sunspecified chordotonal organ | lateral Sk06921 Sk09530 Sk09531 commissure SIIN Sunspecified denticle belt S218 SF126 Sunspecified denticle belt | ventral S1 SIIN dorsal appendage, with Scer\GAL4unspecified Sa.Scer\UAS.P\T dorsal appendage | maternal effect | somatic clone S218 dorsal neurohemal organ S126 dorsocentral bristle SKojak egg chamber SKojak embryonic/first instar larval cuticle S218 SKoj-R2 embryonic/first instar larval cuticle | germline clone | maternal effect SKoj-R1 SKoj-R3 SKoj-R5 embryonic/first instar larval cuticle | maternal effect SKoj-R1 SKoj-R3 embryonic/larval dorsal trunk SIIN embryonic/larval somatic muscle SIIN embryonic/larval stomatogastric nervous system S54 embryonic/larval trachea SIIN embryonic anterior Malpighian tubule SIIN embryonic posterior Malpighian tubule SIIN embryonic ventral epidermis SIIN embryonic ventral nervous system Sunspecified eye S05671 S07056 S1 S104E S48-5 S51 S54 S606 SL SM SW SX Sdb123 Shs.sev Sunspecified eye, with Scer\GAL4GMR.PF SScer\UAS.cGa eye | somatic clone S126 S218 S606 SX155 eye photoreceptor cell S1 S104E S218 Shs.7 Shs.8 fascicle Sk09530 Sk09531 genital disc primordium SIIN interommatidial bristle S1 SKoj-R4 SKojak inter-ommatidial precursor cell | pupal stage P7 S48-5 Keilin's organ S1 SIIN Sunspecified larval sense organ & antennal segment Sunspecified larval sense organ & maxillary segment Sunspecified lch5 neuron SIIN longitudinal connective S1 Sunspecified macrochaeta SKoj-R1 SKoj-R2 SKoj-R3 SKoj-R4 SKoj-R5 SKoj-R6 SKojak mesothoracic tarsal segment 1 & bract S05671 mesothoracic tibial bract S05671 midline glial cell S1 S126 Sunspecified midline glial cell, with Scer\GAL4elav.PLu SScer\UAS.cGa midline ventral glial cell SIIN motor neuron Sunspecified MP1 neuron S1 nurse cell SKojak ommatidium S05671 S1 S48-5 S51 S54 S606 SL SM SW Sdb123 SeAA2 SeAD7 SeAG4 SeAG5 SeAL11 SeAN5 SeAO3 SeAQ3 SeAS5 SeCJ9 SeDO3 SeE6 SeO7 SeQ10 SeT6 SeW4 Shs.7 Shs.8 ommatidium | pupal stage P7 S48-5 ommatidium | somatic clone S606 oocyte SKojak ovariole | germline clone S1 SIIN SKoj-R2 SKoj-R4 SKoj-R6 photoreceptor S05671 photoreceptor cell S48-5 photoreceptor cell R2 S05671 photoreceptor cell R5 S05671 photoreceptor cell R8 S05671 posterior commissure S1 presumptive embryonic/larval central nervous system S05671 S126 S218 S7051 SF126 SX155 Sk06921 SrK134 Sunspecified presumptive embryonic/larval peripheral nervous system Sk06921 Sk09530 Sk09531 Sunspecified scutellar bristle SKojak sensory neuron Sunspecified stomodeal invagination S54 ventral nerve cord SIIN VUM1 neuron S1 VUM2 neuron S1 VUM3 neuron S1 VUM4 neuron S1 VUM5 neuron S1 VUM6 neuron S1 wing Sk09530 wing, with Scer\GAL4Bx-MS1096 SNeo1.Scer\UAS SScer\UAS.cGb wing margin, with Scer\GAL4Bx-MS1096 SNeo1.Scer\UAS wing vein, with Scer\GAL4Bx-MS1096 SDN.Scer\UAS SNeo1.Scer\UAS wing vein | ectopic, with Scer\GAL4Bx-MS1096 SScer\UAS.cGb wing vein | germline clone SX155 wing vein L2 S05671 wing vein L2, with Scer\GAL4Bx-MS1096 SDN.Scer\UAS wing vein L2 | germline clone SX155 wing vein L3 S05671 wing vein L3 | germline clone SX155 wing vein L4 S05671 wing vein L4 | germline clone SX155 wing vein L5 S05671
Classical Alleles ( 128 )
For All Classical Alleles Show
Allele of S Class Mutagen Stocks Known lesion S1 spontaneous 64 Yes S2 spontaneous 14 -- SX X ray 4 -- SIIN amorphic allele - genetic evidence ethyl methanesulfonate 2 -- SEY11186 P-element activity 2 -- Sk09530 P-element activity 2 Yes Sc00080 piggyBac transposase 1 -- Sc01192 1 -- Sd01624 P-element activity 1 -- Se00776 1 -- Sk06101 P-element activity 1 Yes Sk06920 P-element activity 1 -- Sk06921 P-element activity 1 Yes Sk09538a P-element activity 1 -- Sk15907 P-element activity 1 -- SNP5259 1 -- SSC2 ethyl methanesulfonate 1 -- S05671 P-element activity 0 -- S07056 P-element activity 0 -- S104E X ray 0 -- S11 gamma ray 0 -- S126 P-element activity 0 -- S218 ethyl methanesulfonate 0 -- S2J1 ethyl methanesulfonate 0 -- S30 heat-treatment 0 -- S32c heat-treatment 0 -- S39b spontaneous 0 -- S48-5 0 -- S51 U.V. 0 -- S528 0 -- S54 ethyl methanesulfonate 0 Yes S55 ethyl methanesulfonate 0 -- S56 ethyl methanesulfonate 0 -- S57 ethyl methanesulfonate 0 -- S58 ethyl methanesulfonate 0 -- S59 ethyl methanesulfonate 0 -- S606 0 -- S60 ethyl methanesulfonate 0 -- S61 ethyl methanesulfonate 0 -- S62 ethyl methanesulfonate 0 -- S63 ethyl methanesulfonate 0 -- S64 ethyl methanesulfonate 0 -- S65 ethyl methanesulfonate 0 -- S66 ethyl methanesulfonate 0 -- S67 ethyl methanesulfonate 0 -- S7051 P-element activity 0 -- S7 gamma ray 0 -- S8 gamma ray 0 -- SBA651 X ray ethyl methanesulfonate 0 -- SBTE 0 -- SCB-6112-3 0 -- SD-80 gamma ray 0 -- Sdb123 0 -- Se220 ethyl methanesulfonate X ray 0 -- SeAA2 ethyl methanesulfonate 0 -- SeAD7 ethyl methanesulfonate 0 -- SeAG4 ethyl methanesulfonate 0 -- SeAG5 ethyl methanesulfonate 0 -- SeAL11 ethyl methanesulfonate 0 -- SeAN5 ethyl methanesulfonate 0 -- SeAO3 ethyl methanesulfonate 0 -- SeAQ3 ethyl methanesulfonate 0 -- SeAS5 ethyl methanesulfonate 0 -- SeCJ9 ethyl methanesulfonate 0 -- SeDO3 X ray 0 -- SeE6 ethyl methanesulfonate 0 -- SEF2-1 ethyl methanesulfonate 0 -- SEM2-4 ethyl methanesulfonate 0 -- SeO7 ethyl methanesulfonate 0 -- SEP2472 0 -- SeQ10 X ray 0 -- SeT6 X ray 0 -- SeW4 ethyl methanesulfonate 0 -- SF126 P-element activity 0 Yes Shs.7 P-element activity 0 -- Shs.8 wild-type allele P-element activity 0 -- SI 0 -- Sk09312 P-element activity 0 Yes Sk09531 P-element activity 0 Yes Sk09534 P-element activity 0 -- Sk09541 P-element activity 0 -- Sk10232 P-element activity 0 -- Sk14005 P-element activity 0 -- Sk14020 P-element activity 0 -- Sk17024 P-element activity 0 -- SK 0 -- SKoj-R1 0 Yes SKoj-R2 0 Yes SKoj-R3 0 Yes SKoj-R4 0 Yes SKoj-R5 0 Yes SKoj-R6 0 Yes SKojak gain of function allele ethyl methanesulfonate 0 -- SKP347 ethyl methanesulfonate 0 -- SL2-20 0 -- SL X ray 0 -- SM X ray 0 -- SrK134 P-element activity 0 Yes SSC10 ethyl methanesulfonate 0 -- SSC11 ethyl methanesulfonate 0 -- SSC12 ethyl methanesulfonate 0 -- SSC1 ethyl methanesulfonate 0 -- SSC3 ethyl methanesulfonate 0 -- SSC4 ethyl methanesulfonate 0 -- SSC5 ethyl methanesulfonate 0 -- SSC6 ethyl methanesulfonate 0 -- SSC7 ethyl methanesulfonate 0 -- SSC8 ethyl methanesulfonate 0 -- SSC9 ethyl methanesulfonate 0 -- SSCG10 gamma ray 0 -- SSCG11 gamma ray 0 -- SSCG12 gamma ray 0 -- SSCG1 gamma ray 0 -- SSCG2 gamma ray 0 -- SSCG3 gamma ray 0 -- SSCG4 gamma ray 0 -- SSCG5 gamma ray 0 -- SSCG6 gamma ray 0 -- SSCG7 gamma ray 0 -- SSCG8 gamma ray 0 -- SSCG9 gamma ray 0 -- SSCP1 PM hybrid dysgenesis 0 -- SSCP2 PM hybrid dysgenesis 0 -- SSCP3 PM hybrid dysgenesis 0 -- SU132 X ray ethyl methanesulfonate 0 -- Sunspecified ethyl methanesulfonate X ray 0 -- SW X ray 0 -- SX155 X ray 0 --
Alleles Carried on Transgenic Constructs ( 24 )
For All Alleles Carried on Transgenic Constructs Show
Allele of S Class Mutagen Stocks Known lesion SScer\UAS.cBa in vitro construct - regulatory fusion 1 Yes SScer\UAS.T:Ecol\lexA,T:Hsim\VP16 in vitro construct - regulatory fusion in vitro construct - coding region fusion 1 Yes Sa.Scer\UAS.P\T in vitro construct - regulatory fusion 0 Yes SAct5C.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes SC1.Scer\UAS.T:Ecol\lexA,T:Hsim\VP16 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes SDN.Scer\UAS Delta2-3 0 Yes SGD798 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Shs.30 in vitro construct - regulatory fusion 0 Yes Shs.PK in vitro construct - regulatory fusion 0 Yes Shs.PS in vitro construct - regulatory fusion 0 Yes Shs.sev in vitro construct - regulatory fusion 0 Yes Shs.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes SKK110371 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes SMtnA.PL in vitro construct - regulatory fusion 0 Yes SMtnA.PR in vitro construct - regulatory fusion 0 Yes SMtnA.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes SNeo1.Scer\UAS Delta2-3 0 Yes SNeo2.Scer\UAS Delta2-3 0 Yes SScer\UAS.cGa in vitro construct - regulatory fusion 0 Yes SScer\UAS.cGb in vitro construct - regulatory fusion 0 Yes SScer\UAS.NTM.T:Ivir\HA1 in vitro construct - deletion in vitro construct - coding region fusion 0 Yes SScer\UAS.P\T.cGa in vitro construct - regulatory fusion 0 Yes SScer\UAS.T:Ivir\HA1 in vitro construct - coding region fusion 0 Yes SScer\UAS.TMC.T:Ivir\HA1 in vitro construct - deletion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)ast1 (BDGP Project Members, 1994-1999, Dickson et al., 1996) Df(2L)ast2 (Spradling et al., 1999, Thibault et al., 2004, BDGP Project Members, 1994-1999, Kolodkin et al., 1994, Begemann et al., 1995, Kania et al., 1995, Harbecke and Lengyel, 1995, Clegg et al., 1997) Df(2L)ast10 (BDGP Project Members, 1994-1999) Df(2L)S1 (Lewis, 1945) Df(2L)S2 (Tearle and Nusslein-Volhard, 1987, Lewis, 1945, Harbecke and Lengyel, 1995) Df(2L)S3 (Sapir et al., 1998, Tearle and Nusslein-Volhard, 1987, Lewis, 1945, Dickson et al., 1996) Df(2L)S4 (Lewis, 1945) Df(2L)S5 (Lewis, 1945) In(2L)ast-1 (BDGP Project Members, 1994-1999) In(2LR)S56f   In(2LR)SK (Agol, 1936)
Duplicated in	Dp(2;2)S (Lewis, 1945) In(2LR)Px4
Not disrupted in	Df(2L)al (Lewis, 1945) Df(2L)S2 (BDGP Project Members, 1994-1999, Kania et al., 1995) Df(2R)12 (BDGP Project Members, 1994-1999) Df(2R)stan2 (BDGP Project Members, 1994-1999) Df(2R)X1 (BDGP Project Members, 1994-1999) In(2L)dppho40 (Lewis, 1945) T(Y;2)21E (Lewis, 1945)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data heat-shock construct P{hsp70-S} NA P{hs-S.30} NA P{hs-S.HA} NA P{sE-Star} NA UAS construct P{GD798} NA P{KK110371} NA P{UASp-S.a} NA P{UASp-S.G} NA P{UAS-S.B} NA P{UAS-S.C1-LV} NA P{UAS-S.DN} NA P{UAS-S.LV} NA P{UAS-S.Neo1.Δ} NA P{UAS-S.Neo2} NA P{UAS-Star.G} NA P{UAS-Star.HA1} NA P{UAS-Star.NTM.HA1} NA P{UAS-Star.TMC.HA1} NA P{UAS-Star} NA characterization construct P{UAS-Afra\Ubx.S/T-A.1-5.7} NA P{UAS-Afra\Ubx.S/T-A.1-5} NA P{UAS-gap-GFP.S} NA P{UAS-wld.M} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{FZ}SF126 No P{lacW}l(2)SH2285SH2285 No P{lacW}Sk06101 No P{lacW}Sk06920 No P{lacW}Sk06921 No P{lacW}Sk09312 No P{lacW}Sk09530 No P{lacW}Sk09531 No P{lacW}Sk09534 No P{lacW}Sk09538a No P{lacW}Sk09541 No P{lacW}Sk10232 No P{lacW}Sk14005 No P{lacW}Sk14020 No P{lacW}Sk15907 No P{lacW}Sk17024 No P{lacZ}S7051 No P{lacZ}SKP347 No P{PZ}S05671 No P{PZ}S07056 No P{PZ}SrK134 No insertion of mobile activating element P{EP}SEP2472 NA P{EPgy2}SEY11186 NA P{XP}Sd01624 NA miscellaneous insertions P{}S126 NA P{hsp70-S}7 NA P{hsp70-S}l(2)47Aa1 NA P{RS3}SCB-6112-3 NA PBac{PB}Sc00080 NA PBac{PB}Sc01192 NA PBac{RB}Se00776 NA insertion of enhancer trap binary system P{GawB}SNP5259 No
Gene Ontology: Function, Process & Cellular Component ( 22 unique terms )
Terms Based on Experimental Evidence ( 12 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
behavioral response to ethanol inferred from mutant phenotype (Corl et al., 2009) compound eye retinal cell programmed cell death inferred from mutant phenotype (Montrasio et al., 2007) determination of genital disc primordium inferred from mutant phenotype (Chen et al., 2005) epidermal growth factor receptor ligand maturation inferred from genetic interaction with spi (Lee et al., 2001) imaginal disc-derived wing morphogenesis inferred from mutant phenotype (Dworkin and Gibson, 2006) ommatidial rotation inferred from mutant phenotype (Montrasio et al., 2007) protein targeting to Golgi inferred from genetic interaction with spi (Lee et al., 2001) regulation of epidermal growth factor receptor signaling pathway inferred from genetic interaction with rho, spi (Lee et al., 2001) stomatogastric nervous system development inferred from mutant phenotype (Gonzalez-Gaitan and Jackle, 2000)
Cellular Component
CV term Evidence References
endoplasmic reticulum inferred from direct assay (Lee et al., 2001) Golgi apparatus inferred from direct assay (Lee et al., 2001) plasma membrane inferred from direct assay (Lee et al., 2001)
Terms Based on Predictions or Assertions ( 15 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
branched duct epithelial cell fate determination, open tracheal system traceable author statement (Zelzer and Shilo, 2000) compound eye photoreceptor development non-traceable author statement (Swiss-Prot Project Members, 1995.6.1) embryo development traceable author statement (Prokopenko et al., 2000) epidermal growth factor receptor signaling pathway non-traceable author statement (Swiss-Prot Project Members, 1995.6.1) traceable author statement (Bier, 1998) mesoderm development traceable author statement (Prokopenko et al., 2000) oogenesis traceable author statement (Schnorr et al., 2001) peripheral nervous system development traceable author statement (Prokopenko et al., 2000) photoreceptor cell development traceable author statement (Prokopenko et al., 2000) protein targeting to Golgi non-traceable author statement (Swiss-Prot Project Members, 1995.6.1) traceable author statement (Shilo, 2003) regulation of epidermal growth factor receptor signaling pathway traceable author statement (Prokopenko et al., 2000)
Cellular Component
CV term Evidence References
endoplasmic reticulum non-traceable author statement (Swiss-Prot Project Members, 1995.6.1) Golgi apparatus non-traceable author statement (Swiss-Prot Project Members, 1995.6.1) integral to membrane traceable author statement (Prokopenko et al., 2000) membrane non-traceable author statement (Bier, 1998) plasma membrane inferred from sequence or structural similarity (Kolodkin et al., 1994) non-traceable author statement (Kolodkin, 1994.11.25, Swiss-Prot Project Members, 1995.6.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions S allele Gene References S1 aret (Yan and Macdonald, 2004) ast (Lewis, 1945, Kotarski et al., 1998) csw (Firth et al., 2000) Dl (Schultz, 1929) E(S) (Lewis, 1945) Egfr (Kolodkin et al., 1994) ml (Mohr, 1925) net (Lewis, 1945) px (Lewis, 1945) rux (Thomas et al., 1994) Snr1 (Marenda et al., 2004) S2J1 phl (Dickson et al., 1996) phl::tor (Dickson et al., 1996) S48-5 capt (Gaengel and Mlodzik, 2003) chic (Gaengel and Mlodzik, 2003) cno (Gaengel and Mlodzik, 2003) Egfr (Gaengel and Mlodzik, 2003) pnut (Gaengel and Mlodzik, 2003) Ras85D (Gaengel and Mlodzik, 2003) shg (Gaengel and Mlodzik, 2003) spi (Gaengel and Mlodzik, 2003) stan (Gaengel and Mlodzik, 2003) zip (Gaengel and Mlodzik, 2003) S51 ast (Meyer, 1952) S54 ast (Kotarski et al., 1998) H (Johannes and Preiss, 2002) rg (Shamloula et al., 2002) Sos (Kolodkin et al., 1994) S55 Dl (Klein and Campos-Ortega, 1992) S56 Dl (Klein and Campos-Ortega, 1992) S57 Dl (Klein and Campos-Ortega, 1992) S58 Dl (Klein and Campos-Ortega, 1992) S104E sev (Kolodkin et al., 1994) S218 aos (Sawamoto et al., 1996) edl (Yamada et al., 2003) Egfr (Freeman, 1994) rho (Freeman, 1994) spi (Freeman, 1994) S05671 bun (Treisman et al., 1995) Kr (Abrell et al., 2000) Ras85D (Held, 2002) rho (Freeman, 1994) shg (Brown and Freeman, 2003) spi (Brown and Freeman, 2003) S07056 Kr (Abrell et al., 2000) SBA651 aop (Rebay et al., 2000) phl (Rebay et al., 2000) Ras85D (Rebay et al., 2000) Se220 sina (Neufeld et al., 1998) SeAA2 N (Verheyen et al., 1996) SeAD7 N (Verheyen et al., 1996) SeAG4 N (Verheyen et al., 1996) SeAG5 N (Verheyen et al., 1996) SEF2-1 aos (Taguchi et al., 2000) Ras85D (Taguchi et al., 2000) rpr (Taguchi et al., 2000) SEM2-4 aos (Taguchi et al., 2000) Ras85D (Taguchi et al., 2000) rpr (Taguchi et al., 2000) Shs.7 sev (Kolodkin et al., 1994) Shs.8 ast (Kolodkin et al., 1994) rg (Shamloula et al., 2002) sev (Kolodkin et al., 1994) Shs.30 rg (Shamloula et al., 2002) Shs.PK rho (Guichard et al., 1999) Shs.sev sev (Kolodkin et al., 1994) sty (Casci et al., 1999) SIIN Egfr (Buff et al., 1998) jing (Sonnenfeld et al., 2004) phl (Ruden et al., 1999) Ras85D (Ruden et al., 1999) Src42A (Zhang et al., 1999) Sk09312 Ras85D (Schnorr et al., 2001) Sk09530 H (Johannes and Preiss, 2002) SKojak phl (Ruden et al., 1999) Ras85D (Ruden et al., 1999) sev (Ruden et al., 1999) SL ast (Kotarski et al., 1998) SScer\UAS.cBa Egfr (Buff et al., 1998) grk (Ghiglione et al., 2002) SScer\UAS.cGa spi (Pickup and Banerjee, 1999, Hsiung et al., 2001) SScer\UAS.cGb grk (Guichard et al., 2000) stet (Guichard et al., 2000) SU132 aop (Rebay et al., 2000) phl (Rebay et al., 2000) Ras85D (Rebay et al., 2000) Sunspecified grk (Ghiglione et al., 2002) phl (Therrien et al., 2000) sina (Neufeld et al., 1998) SX155 aos (Sawamoto et al., 1996, Sawamoto et al., 1996) rho (Guichard et al., 1999) stet (Guichard et al., 2000) SX ast (Lewis, 1945) unspecified ast   Dl (Klein and Campos-Ortega, 1992) e(S)   Egfr (Read et al., 2005) ksr (Therrien et al., 2000) mael (Bryant et al., 1997, Clegg et al., 1997) N (Verheyen et al., 1996) Psn (Mahoney et al., 2006) Ret (Read et al., 2005) rho (Sapir et al., 1998) ru (Wasserman et al., 2000)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 59534 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0003310 DroID - A comprehensive database of gene and protein interactions. • FBgn0003310 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33281
Orthologs
Genome-wide drosophilid orthologs	Dana\GF21096 Dere\GG24616 Dgri\GH13204 Dper\GL15087 Dpse\GA18149 Dsim\GD22931 Dvir\GJ16115 Dwil\GK24332 Dyak\GE15810
Curated drosophilid orthologs	Dpro\S (Spassky et al., 1950) Dpse\GA18149   Dpse\Ro (Sturtevant and Novitski, 1941, Sturtevant and Tan, 1937) Dvir\St (Sturtevant and Novitski, 1941) Dwil\S (Spassky and Dobzhansky, 1950)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL005704-PA Aedes aegypti (mosquito) XP_001947802.1 Acyrthosiphon pisum (pea aphid) CPIJ000923 Culex pipens (mosquito) 218731 Capitella spl (polychaete worm) XP_966666.1 Tribolium castaneum (red flour beetle) 9966 Thalassiosira pseudonana (marine diatom) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB11508 NV22267 LH25147 FBgn0233375 FBgn0226292 FBgn0203300 FBgn0194325 FBgn0171544 JGI_V11_108484 JGI_V11_253743 JGI_V11_325755 JGI_V11_224483 JGI_V11_103026 JGI_V11_314237 JGI_V11_322909 JGI_V11_260927 JGI_V11_260938 JGI_V11_323557 JGI_V11_326665 JGI_V11_264358 JGI_V11_105159 JGI_V11_255633 JGI_V11_327085 JGI_V11_111607 JGI_V11_264435 JGI_V11_229355 JGI_V11_301984 JGI_V11_268273 JGI_V11_335870 FBgn0078157 FBgn0152691 FBgn0120681 FBgn0116748 FBgn0098101 CPIJ000923 BGIBMGA010766 GB13389 AAEL005704 GLEAN_12408
Stocks & Reagents
Stocks Listed in FlyBase ( 101 )
Bloomington	29860 w1118; P{UAS-S.LV}2 8616 S1/SM1; Sb1/TM6 5365 y1 w*; P{UAS-S.B}28-29-1 33233 w*; S1/CyO; P{ID.QF}Q33A 24153 w*; Df(2L)RACK1-mts/CyO, S2 33218 w*; S1/CyO; P{ID.VP16AD}D37.1
Harvard	- P{XP}Sd01624 - PBac{PB}Sc00080 - PBac{PB}Sc01192 - PBac{RB}Se00776
Kyoto	102716 w67c23 ; P{lacW}Sk09538a / CyO 105842 ex1 ds1 SX astX/SM1
	More stocks available...
Genomic Clones ( 2 )
	BACR23E23 BACR35O22 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 78 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT04225
Other clones	DPiM_AT04225
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT06801 AT19994 GH22801 RE62373 RE62973 SD28010
Other clones	CK01.38B.D8 CK01.100A.C6 EK026120 EK072826 EK077735 EK084633 EK085335 EK092033 EK120227 EK131141 EK171515 EK190921 EK208933 EK252438 EP14260 FGM230B09 LD12914 LD30846 RP003021517 RP003024411 RP003039076 RP003046350 RP003060562 RP003066434 RP003072517 RP003078455 RP003079638 RP003125792 RP003128008 RP003142085 RP003143748 RP003167031 RP003176596 RP003186536 RP003200775 RP003231389 RP003239815 RP003242224 RP003276592 RP003280276 RP003287017 RP003291572 RP003315543 RP003324925 RP003329896 RP003332209 RP003336176 RP003338082 RP003348289 RP003364148 RP003383956 RP003413635 RP003437163 RP003473008 RP003479856 RP003491679 RP003498713 RP003501487 RP003506270 RP003528755 RP003537330 RP003620272 RP003622147 RP003629422 RP003638296 RP003659014 RP003666336 RP003671277 RP003674366 RP003681763
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0003310 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33281
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: S CG4385 (Li, 1999.11)
Source for database merge of	Source for merge of: S l(2)c00080 (Gene Disruption Project members and Exelixis, 2005) Source for merge of: S l(2)k09538 (Freeman, 2000.11.29)
Additional comments	Shs.8 (FBrf0073598) rescues the embryonic lethality of S104E and S1, and the rough eye phenotype of ast, even in the absence of heat shock. On the basis of this rescue, ast and S merged to same gene. Split again on the basis of molecular data (FBrf0085372) Many deficiencies were formerly described as alleles (see Df(2L)S).
Other Comments
	S protein appears to traffic the spi precursor while cycling between the endoplasmic reticulum and late endosomes in S[[2]]R[+] cells. (Tsruya et al., 2007) Cleavage of the S protein (by rho or ru protein) leads to its inactivation as a spi chaperone. (Tsruya et al., 2007) S may have a role in spi processing or transmission. (Hsiung et al., 2001) S interacts directly with spi. (Hsiung et al., 2001) S is required to export spi protein from the endoplasmic reticulum to the Golgi apparatus. (Lee et al., 2001) rho and S function in a synergistic and co-dependent manner, that is independent of spi, to promote vein development through the Egfr/MAPK signalling pathway. (Guichard et al., 1999) Four EMS induced alleles were identified in a screen for mutations affecting commissure formation in the CNS of the embryo. (Hummel et al., 1999) S protein is likely to be involved in spi ligand processing. (Pickup and Banerjee, 1999) 6 "ES2-4" alleles of S have been isolated in a screen for dominant modifiers of the sinaGMR.PN eye phenotype. (Neufeld et al., 1998) Genetic interaction studies suggest the S gene may participate in Egfr signalling in the ovary. (Sapir et al., 1998) In vivo culture of mutant discs from genotypes that are normally embryonic lethal demonstrates S has no role in wing disc growth. (Simcox, 1997) Identified in a genetic screen for modifiers of the phl::tor12D.sev rough eye mutant phenotype. (Dickson et al., 1996) The function of spi, rho and S appears to be non-autonomous; expression of the precursor only in the midline is sufficient for patterning the ventral ectoderm. Facilitating the expression of spi, rho and S is the only sim-dependent contribution of the midline to patterning the ventral ectoderm, since the mutant sim ectodermal defects can be overcome by expression of secreted spi in the ectoderm. These results suggest a mechanism for generating a graded distribution of secreted spi, which may subsequently give rise to graded activation of Egfr in the ectoderm. (Golembo et al., 1996) S mutants show a suppressive effect on mutant argos phenotypes. (Sawamoto et al., 1996) Studies of interaction between argos and members of the Ras/MAPK pathway demonstrate the argos gene product is a negative regulator of signal transduction that acts upstream of the Ras/MAPK cascade. (Sawamoto et al., 1996) The spi product triggers the Egfr signaling cascade. Graded activation of the Egfr pathway may normally give rise to a repertoire of discrete cell fates in the ventral ectoderm and graded distribution of spi may be responsible for the graded activation. The rho and S products may act as modulators of Egfr signaling. Epistatic relationships suggest that rho and S may normally facilitate processing of the spi precursor. (Schweitzer et al., 1995) Alleles of S and of ro have been identified in a screen for abnormal numbers of R8 cells. (Spencer et al., 1995) The interaction of rap and rg with S is synergistic and dosage sensitive. (Venkatesh et al., 1995) Mutations can act as dominant modifiers of the activated N eye phenotype (FBrf0064452). (Verheyen et al., 1995) Rescue analysis of mutant alleles with heat inducible S constructs shows that the asteroid mutants are a viable class of alleles in the S gene. (Kolodkin et al., 1994) Loss of function mutations in S act as suppressors of R7 development in a sensitized genetic background involving Sos, and overexpression of S enhances R7 development in this genetic background. (Kolodkin et al., 1994) S plays an early role in photoreceptor development, and interacts with Egfr in the developing eye. S may also have a later role in photoreceptor development including the recruitment of the R7 cell through the sev pathway. (Kolodkin et al., 1994) The differentiation of individual mesectoderm cells (MECs) lineages is traced. S is necessary for determining the correct number of cells in many neuronal MEC lineages. The correct number of midline glia are determined but later become apoptotic in embryos mutant for S. (Sonnenfeld and Jacob, 1994) S function is required for the reception of a signal and/or the execution of a developmental program that leads to the neuronal differentiation of photoreceptors R8, R2 and R5. S is also required for the formation of the wing veins. Dosage-dependent genetic interaction between S and sev, Ras85D and Sos (involved in receptor tyrosine kinase signalling) supports a role for S in cell-cell signalling. (Heberlein et al., 1993) Molecular data and phenotypic interactions are consistent with the interpretation that S and ast mutations are lesions within the same gene or within genes that are functionally related. (Higson et al., 1993) rho gene product acts synergistically with Egfr signalling components. (Sturtevant et al., 1993) A screen that identified Dominant suppressors of the wing phenotype associated with Dl9P and DlFE32 identified 14 new S alleles. (Klein and Campos-Ortega, 1992) S mutants have a weak salivary placode phenotype: the placodes are separated by two cells instead of four. (Panzer et al., 1992) Zygotically active locus involved in the terminal developmental program in the embryo. (Strecker et al., 1991) rho, pnt, S and spi all function in the formation of the same chordotonal organs. (Bier et al., 1990) ve, vn, ci, cg, svs, ast (S), H, Vno and vvl belong to the vein phenotypic group (Puro, 1982, D. I. S. 58:205--208) within the 'lack-of-vein' mutant class. Loss-of-function alleles at these loci remove stretches of veins in two or more longitudinal veins. Double mutations within members of this group remove all veins, have smaller, slightly lanceolate wings, no sensilla and extra chaetae. (Diaz-Benjumea et al., 1989) Eyes slightly smaller and narrower than wild type; texture somewhat rough from rounded, irregular facets. Arrangement of hairs on surface of eye irregular. S/ast has small rough eyes; S ast/+ + is like S/+. Enhanced by E(S); partially suppresses px and net (Bedichek, 1936; Lewis, 1945). Homozygote dies in late embryonic stage (Sivertzev-Dobzhansky, 1927; Sonnenblick and Huettner, 1938). A member of the so-called spitz group of mutants; embryos lack structures derived from ventral-lateral region of blastoderm. Denticle bands narrow and ventral arms of head skeleton fused. Anal pads reduced. Transverse commissures of ventral nervous system reduced; Keilin organs, maxillary and antennal sense organs strongly reduced. Lethal in homozygous clones in female germ line (Nusslein-Volhard, Wieschaus and Kluding, 1984; Mayer and Nusslein-Volhard, 1988).
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078726 NM_164403 RefSeq (Proteins) • NP_523450 NP_722674 DDBJ / EMBL / GenBank • AA438599 AAB04161 AAF51425 AAM29206 AAN10478 AF174675 AF174676 AQ025780 AQ025896 AY113201 BF495387 CL844419 CZ466184 CZ472344 G00465 L31886 Z31977 Z32315 Entrez Gene - A searchable database of RefSeq genes. • 33281 UniProtKB/Swiss-Prot • P42519
Other Crossreferences
Linkouts
	BioGRID - A database of protein and genetic interactions • 59534 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0003310 DroID - A comprehensive database of gene and protein interactions. • FBgn0003310 DRSC - Results from RNAi screens. • FBgn0003310 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003310 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4385-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0003310 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33281 InParanoid A subset of ortholog calls from InParanoid. • AAEL005704-PA Aedes aegypti (mosquito) XP_001947802.1 Acyrthosiphon pisum (pea aphid) CPIJ000923 Culex pipens (mosquito) 218731 Capitella spl (polychaete worm) XP_966666.1 Tribolium castaneum (red flour beetle) 9966 Thalassiosira pseudonana (marine diatom) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /torstoll/star.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33281 modMine - Data generated by the modENCODE project. • FBgn0003310 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB11508 NV22267 LH25147 FBgn0233375 FBgn0226292 FBgn0203300 FBgn0194325 FBgn0171544 JGI_V11_108484 JGI_V11_253743 JGI_V11_325755 JGI_V11_224483 JGI_V11_103026 JGI_V11_314237 JGI_V11_322909 JGI_V11_260927 JGI_V11_260938 JGI_V11_323557 JGI_V11_326665 JGI_V11_264358 JGI_V11_105159 JGI_V11_255633 JGI_V11_327085 JGI_V11_111607 JGI_V11_264435 JGI_V11_229355 JGI_V11_301984 JGI_V11_268273 JGI_V11_335870 FBgn0078157 FBgn0152691 FBgn0120681 FBgn0116748 FBgn0098101 CPIJ000923 BGIBMGA010766 GB13389 AAEL005704 GLEAN_12408
Synonyms & Secondary IDs ( 20 )
Reported As
Symbol Synonym	CG4385 (Freeman, 2000.11.29, Ida et al., 2009, Keleman et al., 2009.8.5) E(Raf)2B   EK2-2 (Therrien et al., 2000) ES2-4 (Neufeld et al., 1998) EY2-4 (Rebay et al., 2000) fltr (Kania et al., 1995, ) l(2)21Eb   l(2)05671 (Abrell et al., 2000, ) l(2)07056 (Abrell et al., 2000, ) l(2)c00080   l(2)k09538   l(2)rK134   S (Dworkin and Gibson., 2006, Kim et al., 2007, Duncan and Celniker, 2004, Dworkin and Gibson, 2006, Mahoney et al., 2006, Terriente and de Celis, 2007, Curtis et al., 2011, Maeda et al., 2007, Montrasio et al., 2007, Yogev et al., 2008, Brown et al., 2007, Huh et al., 2009, Ida et al., 2009, Corl et al., 2009, Zeitlinger et al., 2007, Oishi et al., 2006, Oishi et al., 2009, Iyadurai et al., 2008, Terriente-Félix et al., 2010, Lee et al., 1999, Chang et al., 2001, Jiang et al., 2011, Dworkin et al., 2011) star (White, 2002) Star (Foltenyi et al., 2007, Protzer et al., 2008) Star/asteroid (Schnorr and Berg, 1997, Higson et al., 1993) unnamed (Thibault et al., 2004)
Name Synonym	Enhancer of GMR-sina 2-4 (Neufeld et al., 1998) floater (Prokopenko and Bellen, 1997.1.7, Kania et al., 1995, ) lethal (2) c00080   star (Dworkin and Gibson., 2006, Sandmann et al., 2006, Figeac et al., 2010, Liu et al., 2010) Star (Klambt, 2000, Kolodkin, 1994.11.25, Guichard et al., 1997, Duncan and Celniker, 2004, Schlesinger and Shilo, 2005, Tyler et al., 2007, Dworkin and Gibson, 2006, Yogev et al., 2007, Urban, 2006, Stathopoulos and Levine, 2005, Miura et al., 2006, Yogev et al., 2008, Maeda et al., 2007, Zarnescu et al., 2005, Foltenyi et al., 2007, Gonzalez-Gaitan and Jackle, 2000, Wech and Nagel, 2005, Montrasio et al., 2007, Tsruya et al., 2007, Yogev et al., 2008, Dimitri et al., 2003, Iyadurai et al., 2008, Melicharek et al., 2008, Castro et al., 2007, Kelkar and Dobberstein, 2009, Hurlbut et al., 2009, Schlesinger et al., 2004, Corl et al., 2009, O'Keefe et al., 2009, Oishi et al., 2006, Oishi et al., 2009, Brown et al., 2007, Terriente-Félix et al., 2010, Kitadate and Kobayashi, 2010, Figeac et al., 2010, Lee et al., 1999, Chang et al., 2001, Jiang et al., 2011, Rousso et al., 2010)
Secondary FlyBase IDs
	FBgn0010102 FBgn0010674 FBgn0069199
References ( 312 )
Generate a list of	All references relating to this gene ( 312 )
List References by type	Research paper  ( 186 ) Supplementary material  ( 6 ) Review  ( 41 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 52 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 2 ) Obituary  ( 3 ) Curated genome annotation  ( 1 ) Computer file  ( 4 ) Stock list  ( 1 ) Protein sequence record  ( 1 ) Book  ( 3 ) Teaching note  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 8 )
	Curtis et al., 2011, Dev. Biol. 350(2): 534--547 Histone lysine demethylases function as co-repressors of SWI/SNF remodeling activities during Drosophila wing development. [FBrf0212876] Dworkin et al., 2011, Genetics 187(4): 1171--1184 The effects of weak genetic perturbations on the transcriptome of the wing imaginal disc and its association with wing shape in Drosophila melanogaster. [FBrf0214376] Jiang et al., 2011, Cell Stem Cell 8(1): 84--95 EGFR/Ras/MAPK Signaling Mediates Adult Midgut Epithelial Homeostasis and Regeneration in Drosophila. [FBrf0212694] Figeac et al., 2010, Development 137(12): 1965--1973 Drosophila adult muscle precursors form a network of interconnected cells and are specified by the rhomboid-triggered EGF pathway. [FBrf0210887] Kitadate and Kobayashi, 2010, Proc. Natl. Acad. Sci. U.S.A. 107(32): 14241--14246 Notch and Egfr signaling act antagonistically to regulate germ-line stem cell niche formation in Drosophila male embryonic gonads. [FBrf0211513] Liu et al., 2010, Sci. Signal. 3(132): ra57 The Drosophila Female Germline Stem Cell Lineage Acts to Spatially Restrict DPP Function Within the Niche. [FBrf0211426] Rousso et al., 2010, Development 137(20): 3427--3437 Generation of distinct signaling modes via diversification of the Egfr ligand-processing cassette. [FBrf0211899] Terriente-Félix et al., 2010, Genetics 185(2): 671--684 Identification of genes affecting wing patterning through a loss-of-function mutagenesis screen and characterization of med15 function during wing development. [FBrf0211230] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...