FB2019_05, released Oct 15, 2019

Gene: Dmel\sax

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General Information
Symbol
Dmel\sax
Species
D. melanogaster
Name
saxophone
Annotation Symbol
CG1891
Feature Type
protein_coding_gene
FlyBase ID
FBgn0003317
Gene Model Status
Current
Stock Availability
22 publicly available
Enzyme Name (EC)
Receptor protein serine/threonine kinase (2.7.11.30)
Gene Snapshot
saxophone (sax) encodes a type I BMP receptor. Together with the BMP receptors encoded by tkv and put, it transduces signaling of the BMP ligands encoded by dpp, gbb and scw, in a wide variety of developmental processes including embryonic and imaginal disc patterning. [Date last reviewed: 2019-03-14]
Other Summaries
Also Known As
Brk43E
Key Links
Genomic Location
Cytogenetic map
43E18-43E18
Sequence location
2R:7,806,484..7,810,067 [+]
Recombination map
2-57
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Pathway (FlyBase)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
contributes_tocontributes_to BMP binding; BMP receptor activity; I-SMAD binding; transmembrane receptor protein serine/threonine kinase activity
Predictions / Assertions
ATP binding; metal ion binding; protein serine/threonine kinase activity; transforming growth factor beta receptor activity, type I
Catalytic Activity (EC)
Experimental Evidence
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate (2.7.11.30)
Predictions / Assertions
-
Summaries
Pathway (FlyBase)
BMP Signaling Pathway Core Components -
The Bone Morphogenetic Protein (BMP) signaling pathway is one of two branches of Transforming Growth Factor-β family signaling in Drosophila. The binding of a BMP family dimer to a heterodimeric serine/threonine kinase receptor complex results in the phosphorylation of Mad, a member of the Smad family. Mad forms a complex with the co-Smad, Med. This complex translocates into the nucleus and regulates the transcription of target genes in concert with other nuclear cofactors. (Adapted from FBrf0236482.)
Gene Group (FlyBase)
TGF-BETA TYPE I RECEPTORS -
The Transforming Growth Factor-β Receptor (TGF-βR) family are transmembrane serine/threonine kinases. They form heterodimeric receptor complexes composed of type I and type II subunits. Upon ligand binding, the constitutively active type II receptor phosphorylates the type I receptor which, in turn, phosphorylates a member of the Smad family. (Adapted from FBrf0236482.)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
sax: saxophone (T. Schupbach and E. Wieschaus)
Maternal effect lethal, female sterile. Embryos from homozygous mothers gastrulate abnormally. The cephalic furrow is more pronounced than in wildtype. The phenotype is reminiscent of the zygotic embryonic lethal mutaton twisted gastrulaton (twg).
Summary (Interactive Fly)
receptor s/t kinase - a type I Dpp receptor - necessary for the specification of the dorsal-most cell fate (amnioserosa) which requires the highest levels of Dpp activity - together with the BMP receptors Tkv and Put, Sax transduces signaling of the BMP ligands Dpp, Gbb and Scw in the embryo and in imaginal disc patterning
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
3

Please see the GBrowse view of Dmel\sax or the JBrowse view of Dmel\sax for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.40
Gene model reviewed during 5.49
Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
sax-RA
FBtr0088832
NM_078928
2415
570
sax-RB
FBtr0088833
NM_165559
2716
535
sax-RC
FBtr0308825
NM_001259264
2451
582
Additional Transcript Data and Comments
Reported size (kB)
3 (northern blot)
(Penton et al., 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
sax-PA
FBpp0087908
64.2
570
6.80
NP_523652
AAF59189
sax-PB
FBpp0087909
60.1
535
7.33
NP_724606
AAM68863
sax-PC
FBpp0300982
65.9
582
7.73
NP_001246193
AFH07948
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
570 (aa)
(Brummel et al., 1994, Nellen et al., 1994, Penton et al., 1994)
570 (aa); 62 (kD predicted)
(Xie et al., 1994)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\sax using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (28 terms)
Molecular Function (8 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
BMP binding
inferred from direct assay
(Brummel et al., 1994)
contributes_to BMP binding
inferred from direct assay
(Lee-Hoeflich et al., 2005, Letsou et al., 1995)
BMP receptor activity
inferred from direct assay
(Shimmi et al., 2005, Brummel et al., 1994)
inferred from mutant phenotype
(Shimmi et al., 2005)
I-SMAD binding
inferred from physical interaction with FLYBASE:Dad; FB:FBgn0020493
(Kamiya et al., 2008)
transmembrane receptor protein serine/threonine kinase activity
inferred from direct assay
(Kamiya et al., 2008)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
ATP binding
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
metal ion binding
inferred from electronic annotation with InterPro:IPR017194
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
protein serine/threonine kinase activity
inferred from biological aspect of ancestor with PANTHER:PTN000583675
(assigned by GO_Central )
(Gaudet et al., 2011)
transforming growth factor beta receptor activity, type I
non-traceable author statement
(Singer et al., 1997)
inferred from biological aspect of ancestor with PANTHER:PTN002356032
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (16 terms)
Terms Based on Experimental Evidence (12 terms)
CV Term
Evidence
References
anterior/posterior pattern specification, imaginal disc
inferred from mutant phenotype
(Singer et al., 1997)
BMP signaling pathway
inferred from mutant phenotype
(Twombly et al., 2009, Shimmi et al., 2005, Shimmi et al., 2005, McCabe et al., 2004, Haerry et al., 1998, Nellen et al., 1994)
inferred from genetic interaction with FLYBASE:scw; FB:FBgn0005590
(Nguyen et al., 1998)
inferred from genetic interaction with FLYBASE:gbb; FB:FBgn0024234
(Haerry et al., 1998)
inferred from genetic interaction with FLYBASE:dpp; FB:FBgn0000490
(Twombly et al., 1996, Brummel et al., 1994, Nellen et al., 1994, Penton et al., 1994, Xie et al., 1994)
inferred from direct assay
(Kamiya et al., 2008)
inferred from genetic interaction with FLYBASE:put; FB:FBgn0003169
(Letsou et al., 1995)
defense response to Gram-negative bacterium
inferred from high throughput mutant phenotype
(Cronin et al., 2009)
dorsal/ventral pattern formation
inferred from mutant phenotype
(Nellen et al., 1994)
inferred from genetic interaction with FLYBASE:dpp; FB:FBgn0000490
(Nellen et al., 1994)
germ-line stem cell division
inferred from mutant phenotype
(Xie and Spradling, 1998)
germ-line stem cell population maintenance
inferred from mutant phenotype
(Xie and Spradling, 1998)
imaginal disc-derived wing morphogenesis
inferred from mutant phenotype
(Haerry, 2010, Dworkin and Gibson, 2006, Nguyen et al., 1998, Singer et al., 1997)
maternal determination of anterior/posterior axis, embryo
inferred from high throughput mutant phenotype
(Schupbach and Wieschaus, 1989)
negative regulation of innate immune response
inferred from high throughput mutant phenotype
(Cronin et al., 2009)
ovarian follicle cell development
inferred from mutant phenotype
(Twombly et al., 1996)
positive regulation of synaptic growth at neuromuscular junction
inferred from mutant phenotype
(McCabe et al., 2004)
wing disc pattern formation
inferred from mutant phenotype
(Twombly et al., 2009, Haerry et al., 1998)
Terms Based on Predictions or Assertions (6 terms)
CV Term
Evidence
References
BMP signaling pathway
inferred from biological aspect of ancestor with PANTHER:PTN002356032
(assigned by GO_Central )
(Gaudet et al., 2011)
cellular response to growth factor stimulus
inferred from biological aspect of ancestor with PANTHER:PTN000583675
(assigned by GO_Central )
(Gaudet et al., 2011)
compound eye morphogenesis
non-traceable author statement
(Baker, 2001)
ovarian follicle cell development
traceable author statement
(Dobens and Raftery, 2000)
protein phosphorylation
inferred from biological aspect of ancestor with PANTHER:PTN002758232
(assigned by GO_Central )
(Gaudet et al., 2011)
transforming growth factor beta receptor signaling pathway
inferred from electronic annotation with InterPro:IPR017194
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
BMP receptor complex
inferred from physical interaction with UniProtKB:P50488
(Brummel et al., 1994)
inferred from physical interaction with FLYBASE:put; FB:FBgn0003169
(Letsou et al., 1995)
inferred from physical interaction with FLYBASE:wit; FB:FBgn0024179
(Lee-Hoeflich et al., 2005)
plasma membrane
inferred from high throughput direct assay
(Sarov et al., 2016)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
BMP receptor complex
inferred from biological aspect of ancestor with PANTHER:PTN002356032
(assigned by GO_Central )
(Gaudet et al., 2011)
integral component of plasma membrane
inferred from sequence or structural similarity with MGI:MGI:87911
(Xie et al., 1994)
plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN002758232
(assigned by GO_Central )
(Gaudet et al., 2011)
receptor complex
inferred from biological aspect of ancestor with PANTHER:PTN000583675
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- adult stage
organism | ubiquitous
(Brummel et al., 1994)
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
organism | ubiquitous
(Penton et al., 1994)
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
foregut primordium
(Fisher et al., 2012)
hindgut proper primordium
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 13 -- 16
dorsal pharyngeal muscle
(Fisher et al., 2012)
embryonic hindgut
(Fisher et al., 2012)
embryonic Malpighian tubule
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
embryonic/larval muscle system
(Fisher et al., 2012)
gonad
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
Additional Descriptive Data
sax transcripts are expressed ubiquitously in all tissues and at all stages of development.
(Brummel et al., 1994)
Uniform sax expression was observed in early embryos. While the levels decline in later embryos, expression remains ubiquitous.
(Penton et al., 1994)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
BMP receptor complex
inferred from physical interaction with UniProtKB:P50488
(Brummel et al., 1994)
inferred from physical interaction with FLYBASE:put; FB:FBgn0003169
(Letsou et al., 1995)
inferred from physical interaction with FLYBASE:wit; FB:FBgn0024179
(Lee-Hoeflich et al., 2005)
plasma membrane
inferred from high throughput direct assay
(Sarov et al., 2016)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\sax in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 23 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 37 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of sax
Transgenic constructs containing regulatory region of sax
Deletions and Duplications ( 13 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal (with Df(2R)BSC265)
lethal (with Df(2R)H23)
lethal (with Df(2R)sax1rv2)
lethal (with Df(2R)saxPE7)
lethal (with Df(2R)sax-H9)
lethal (with sax1rv1)
lethal (with sax1rv5)
lethal (with sax3)
lethal (with sax4)
lethal (with sax5)
lethal (with sax6)
lethal (with saxP)
lethal (with saxPE5)
lethal (with saxPE10)
lethal | larval stage
lethal | larval stage (with Df(2R)H23)
lethal | larval stage (with sax1rv1)
lethal | larval stage (with sax3)
lethal | larval stage (with sax4)
lethal | larval stage (with sax5)
lethal | larval stage (with sax6)
lethal | maternal effect
lethal | maternal effect (with Df(2R)H23)
lethal | maternal effect (with Df(2R)sax-H9)
lethal | maternal effect (with sax1rv1)
lethal | maternal effect (with sax2)
lethal | maternal effect | recessive
lethal | P-stage (with Df(2R)H23)
lethal | P-stage (with sax1rv1)
lethal | P-stage (with sax3)
lethal | P-stage (with sax4)
lethal | P-stage (with sax5)
lethal | P-stage (with sax6)
lethal | recessive
lethal - all die before end of embryonic stage | germline clone | non-rescuable maternal effect | recessive
lethal - all die before end of embryonic stage | maternal effect
lethal - all die before end of embryonic stage | maternal effect (with Df(2R)H23)
lethal - all die before end of embryonic stage | maternal effect (with Df(2R)P32a)
lethal - all die before end of embryonic stage | maternal effect (with sax1)
lethal - all die before end of embryonic stage | maternal effect (with sax2)
lethal - all die before end of embryonic stage | maternal effect | recessive
partially lethal - majority die (with Df(2R)H23)
partially lethal - majority die (with Df(2R)sax1rv2)
partially lethal - majority die (with Df(2R)sax-H9)
partially lethal - majority die (with sax1rv1)
partially lethal - majority die (with sax3)
partially lethal - majority die (with sax4)
partially lethal - majority die (with sax5)
partially lethal - majority die (with sax6)
partially lethal - majority die (with saxP)
partially lethal - majority die | maternal effect (with Df(2R)H23)
partially lethal - majority die | maternal effect (with Df(2R)P32a)
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
viable (with Df(2R)H23)
viable (with Df(2R)sax1rv2)
viable (with Df(2R)sax-H9)
viable (with sax1)
viable (with sax1rv1)
viable (with sax1rv5)
viable (with sax2)
viable (with sax3)
viable (with sax4)
viable (with sax5)
viable (with sax6)
viable (with saxP)
Sterility
Allele
female semi-sterile, with Scer\GAL4nos.PG, Scer\GAL4VP16.nos.UTR, Scer\GAL4VP16.otu
female semi-sterile, with Scer\GAL4VP16.mat.αTub67C
female sterile
female sterile | recessive
Other Phenotypes
Allele
circadian rhythm defective, with Scer\GAL4P2.4.Pdf
developmental rate defective | larval stage (with Df(2R)H23)
increased cell number | progressive, with Scer\GAL4nos.PU
increased occurrence of cell division | adult stage, with Scer\GAL4hh.PU
neuroanatomy defective
neuroanatomy defective (with Df(2R)cn7969)
neuroanatomy defective (with Df(2R)sax-H9)
neurophysiology defective (with sax4)
neurophysiology defective (with sax5)
size defective | adult stage, with Scer\GAL4dsx.KI
size defective | adult stage, with Scer\GAL4esg.PU
size defective | larval stage (with Df(2R)H23)
some die during embryonic stage | maternal effect
some die during embryonic stage | maternal effect (with Df(2R)H23)
some die during embryonic stage | maternal effect (with Df(2R)P32a)
some die during embryonic stage | maternal effect (with sax1)
some die during embryonic stage | maternal effect (with sax2)
some die during embryonic stage | non-rescuable maternal effect | recessive
some die during embryonic stage | recessive | maternal effect | recessive
visible
visible, with Scer\GAL4A9
visible, with Scer\GAL4ap-md544
visible, with Scer\GAL4Bx-MS1096
visible, with Scer\GAL4en-e16E
visible, with Scer\GAL4pnr-MD237
visible, with Scer\GAL4ptc-559.1
visible | dominant
visible | recessive
visible | recessive | somatic clone
wild-type
Phenotype manifest in
Allele
2nd posterior cell | somatic clone
abdominal segment 7 | maternal effect
abdominal segment 8 | maternal effect
amnioproctodeal invagination | maternal effect
amnioserosa
amnioserosa | maternal effect
amnioserosa | maternal effect (with sax1)
amnioserosa | maternal effect (with sax2)
anterior crossvein
anterior crossvein, with Scer\GAL4ptc-559.1
bouton
bouton (with Df(2R)cn7969)
brain | larval stage (with Df(2R)H23)
cephalic furrow
dense core granule | adult stage, with Scer\GAL4NP0261
discal cell | somatic clone
distal costal vein | ectopic
dorsal appendage
dorsal appendage | germline clone
dorsal double row
dorsal triple row | proximal, with Scer\GAL4A9
egg
egg | germline clone
egg | maternal effect (with Df(2R)H23)
egg | maternal effect (with Df(2R)sax-H9)
egg chamber
egg chamber, with Scer\GAL4hs.PB
egg chamber | germline clone
embryo | extended germ band stage | maternal effect
embryonic/first instar larval cuticle | maternal effect
embryonic/larval dorsal branch, with Scer\GAL4btl.PS
embryonic/larval dorsal branch, with Scer\GAL4esg-p127
embryonic/larval epidermis | dorsal
embryonic/larval epidermis | dorsal | maternal effect
embryonic/larval ganglionic branch
embryonic/larval midgut | embryonic stage
embryonic/larval midgut | embryonic stage | maternal effect
embryonic head | maternal effect
embryonic midgut constriction 2
eye
fat body (with Df(2R)H23)
female germline cyst | progressive, with Scer\GAL4nos.PU
female germline stem cell
female germline stem cell | progressive, with Scer\GAL4nos.PU
filzkorper | maternal effect
germarium
germarium | progressive, with Scer\GAL4nos.PU
germarium cap cell | progressive, with Scer\GAL4nos.PU
imaginal disc
imaginal disc (with Df(2R)H23)
imaginal disc | maternal effect
lysosome | adult stage, with Scer\GAL4dsx.KI
male accessory gland secondary cell, with Scer\GAL4dsx.KI
male accessory gland secondary cell, with Scer\GAL4esg.PU
male accessory gland secondary cell, with Scer\GAL4NP0261
male germline stem cell | germline clone
medial triple row | proximal, with Scer\GAL4A9
mitotic domain 1 | extended germ band stage
multivesicular body | adult stage, with Scer\GAL4dsx.KI
neuromuscular junction (with Df(2R)cn7969)
neuromuscular junction (with Df(2R)sax-H9)
nucleus | adult stage, with Scer\GAL4esg.PU
ommatidium
ovariole
ovary
ovary | germline clone
posterior crossvein, with Scer\GAL4A9
secretory vesicle | adult stage, with Scer\GAL4dsx.KI
synapse
t-bar
trachea | larval stage (with Df(2R)H23)
trichogen cell | supernumerary, with Scer\GAL4pnr-MD237
trichome of the posterior wing margin
triple row | ectopic
ventral double row
ventral triple row | proximal, with Scer\GAL4A9
wing
wing, with Scer\GAL4A9
wing, with Scer\GAL4ap-md544
wing | posterior, with Scer\GAL4en-e16E
wing | somatic clone
wing basal cell 2 | somatic clone
wing blade, with Scer\GAL4Bx-MS1096
wing cell
wing disc, with Scer\GAL4A9
wing vein
wing vein, with Scer\GAL4A9
wing vein, with Scer\GAL4Bx-MS1096
wing vein (with Df(2R)H23)
wing vein (with Df(2R)sax-H9)
wing vein | cell non-autonomous | ectopic | somatic clone
wing vein | ectopic
wing vein | ectopic, with Scer\GAL4A9
wing vein | ectopic, with Scer\GAL4Bx-MS1096
wing vein | ectopic, with Scer\GAL4en-e16E
wing vein | ectopic | somatic clone
wing vein L2, with Scer\GAL4A9
wing vein L4 | somatic clone
wing vein L5, with Scer\GAL4A9
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (7)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\ACVR1
12 of 15
Yes
Yes
 
Hsap\ACVRL1
8 of 15
No
Yes
Hsap\ACVR1B
3 of 15
No
No
 
Hsap\ACVR1C
3 of 15
No
No
Hsap\TGFBR1
3 of 15
No
No
Hsap\BMPR1A
2 of 15
No
No
Hsap\BMPR1B
2 of 15
No
No
 
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (7)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Acvr1
12 of 15
Yes
Yes
Mmus\Acvrl1
8 of 15
No
Yes
Mmus\Acvr1b
3 of 15
No
No
Mmus\Acvr1c
3 of 15
No
No
Mmus\Tgfbr1
3 of 15
No
No
Mmus\Bmpr1a
2 of 15
No
No
Mmus\Bmpr1b
2 of 15
No
No
Rattus norvegicus (Norway rat) (8)
Rnor\Acvr1
10 of 13
Yes
Yes
Rnor\Acvrl1
6 of 13
No
Yes
Rnor\Acvr1b
3 of 13
No
No
Rnor\Tgfbr1
3 of 13
No
No
Rnor\Acvr1c
2 of 13
No
No
Rnor\Bmpr1b
2 of 13
No
No
Rnor\Bmpr1a
1 of 13
No
No
Rnor\LOC103690035
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (6)
Xtro\acvr1
5 of 12
Yes
Yes
Xtro\acvr1b
2 of 12
No
No
Xtro\bmpr1b
2 of 12
No
No
Xtro\tgfbr1
2 of 12
No
No
Xtro\acvr1c
1 of 12
No
No
Xtro\bmpr1a
1 of 12
No
No
Danio rerio (Zebrafish) (10)
Drer\acvr1l
12 of 15
Yes
Yes
Drer\acvrl1
7 of 15
No
Yes
Drer\acvr1bb
3 of 15
No
No
Drer\acvr1ba
2 of 15
No
No
Drer\bmpr1aa
2 of 15
No
No
Drer\bmpr1ba
2 of 15
No
No
Drer\tgfbr1a
2 of 15
No
No
Drer\tgfbr1b
2 of 15
No
No
Drer\acvr1c
1 of 15
No
No
Drer\bmpr1ab
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (3)
Cele\sma-6
5 of 15
Yes
No
Cele\daf-1
2 of 15
No
No
Cele\kin-23
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (7)
Atha\AT2G19210
1 of 9
Yes
Yes
Atha\AT3G45410
1 of 9
Yes
Yes
Atha\AT3G53380
1 of 9
Yes
Yes
Atha\AT4G23050
1 of 9
Yes
Yes
Atha\CRK42
1 of 9
Yes
Yes
Atha\XIP1
1 of 9
Yes
Yes
Atha\YDA
1 of 9
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091904HI )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\sax
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00002884
Drosophila simulans
Dsim\GD15359
Drosophila sechellia
Dsec\GM20983
Drosophila erecta
Dere\GG23304
Drosophila yakuba
Dyak\GE19150
Drosophila ananassae
Dana\GF13635
Drosophila pseudoobscura pseudoobscura
Dpse\GA15112
Drosophila persimilis
Dper\GL10841
Drosophila willistoni
Dwil\GK22220
Drosophila virilis
Dvir\GJ21241
Drosophila mojavensis
Dmoj\GI19992
Drosophila grimshawi
Dgri\GH20320
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091503IG )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17021726
Glossina morsitans
Tsetse fly
Gmor\GMOY010470
Mayetiola destructor
Hessian fly
Mdes\Mdes006553
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL012152
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL015125
Anopheles darlingi
American malaria mosquito
Adar\ADAC006707
Anopheles gambiae
Malaria mosquito
Agam\AGAP007729
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ014117
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W05EX )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA000601
Bombyx mori
Silkmoth
Bmor\BGIBMGA007355
Bombyx mori
Silkmoth
Bmor\BGIBMGA009134
Danaus plexippus
Monarch butterfly
Dple\DPOGS207162-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS213346-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL016363
Heliconius melpomene
Postman butterfly
Hmel\HMEL013045
Heliconius melpomene
Postman butterfly
Hmel\HMEL017087
Apis florea
Little honeybee
Aflo\2539757204
Apis florea
Little honeybee
Aflo\2985342868
Apis florea
Little honeybee
Aflo\4290780692
Apis mellifera
Western honey bee
Amel\GB43676
Apis mellifera
Western honey bee
Amel\tkv
Apis mellifera
Western honey bee
Amel\GB45459
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP24380
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP18681
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP12749
Bombus terrestris
Buff-tailed bumblebee
Bter\15207568
Bombus terrestris
Buff-tailed bumblebee
Bter\15203007
Bombus terrestris
Buff-tailed bumblebee
Bter\15206714
Linepithema humile
Argentine ant
Lhum\LH22869
Linepithema humile
Argentine ant
Lhum\LH21834
Linepithema humile
Argentine ant
Lhum\LH10452
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000899
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000327
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG017531
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG002444
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG027266
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_02202
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_05546
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_10241
Tribolium castaneum
Red flour beetle
Tcas\babo
Tribolium castaneum
Red flour beetle
Tcas\sax
Tribolium castaneum
Red flour beetle
Tcas\tkv
Pediculus humanus
Human body louse
Phum\PHUM581100
Pediculus humanus
Human body louse
Phum\PHUM551530
Pediculus humanus
Human body louse
Phum\PHUM127230
Rhodnius prolixus
Kissing bug
Rpro\tkv
Rhodnius prolixus
Kissing bug
Rpro\RPRC001488
Cimex lectularius
Bed bug
Clec\CLEC011214
Cimex lectularius
Bed bug
Clec\CLEC012731
Cimex lectularius
Bed bug
Clec\CLEC000030
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI008573
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI005313
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_03472
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_04522
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X05B2 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR012082
Strigamia maritima
European centipede
Smar\SMAR004480
Strigamia maritima
European centipede
Smar\SMAR001378
Strigamia maritima
European centipede
Smar\SMAR014992
Strigamia maritima
European centipede
Smar\SMAR013140
Ixodes scapularis
Black-legged tick
Isca\ISCW011054
Ixodes scapularis
Black-legged tick
Isca\ISCW022003
Stegodyphus mimosarum
African social velvet spider
Smim\KFM79206.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM75752.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur22g01550
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_347227
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_347223
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_347224
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0BIU )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Alk4-5-7_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Alk3-6
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Alk2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Alk4-5-7
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000005855
Ciona intestinalis
Vase tunicate
Cint\tgfbr-ic
Ciona intestinalis
Vase tunicate
Cint\tgfbr-ia
Gallus gallus
Domestic chicken
Ggal\BMPR1A
Gallus gallus
Domestic chicken
Ggal\LOC100857446
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000014631
Gallus gallus
Domestic chicken
Ggal\ACVR1C
Gallus gallus
Domestic chicken
Ggal\ChALK5
Gallus gallus
Domestic chicken
Ggal\ACVR1
Gallus gallus
Domestic chicken
Ggal\BMPR1B
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (4)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
babo
5 of 10
tkv
4 of 10
put
2 of 10
wit
2 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 2 )
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
ACVR1; activin A receptor type 1
12 of 15
102576
 
ACVRL1; activin A receptor like type 1
8 of 15
601284
ACVR1B; activin A receptor type 1B
3 of 15
601300
       
      ACVR1C; activin A receptor type 1C
      3 of 15
      608981
          TGFBR1; transforming growth factor beta receptor 1
          3 of 15
          190181
          Functional Complementation Data
          Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
          Interactions
          Summary of Physical Interactions
          esyN Network Diagram
          Show neighbor-neighbor interactions:
          Select Layout:
          Legend:
          Protein
          RNA
          Selected Interactor(s)
          Interactions Browser
          View in Interactions Browser
          Please see the Physical Interaction reports below for full details
          protein-protein
          Physical Interaction
          Assay
          References
          sax
          anti tag coimmunoprecipitation, anti tag western blot
          (Haerry, 2010)
          sax - CG12004
          experimental knowledge based
          (Guruharsha et al., 2011)
          sax - CG14767
          experimental knowledge based
          (Guruharsha et al., 2011)
          sax - CG3164
          experimental knowledge based
          (Guruharsha et al., 2011)
          sax - CG5447
          experimental knowledge based
          (Guruharsha et al., 2011)
          sax - CG7668
          experimental knowledge based
          (Guruharsha et al., 2011)
          sax - Dad
          anti tag coimmunoprecipitation, anti tag western blot
          (Li et al., 2017, Kamiya et al., 2008)
          sax - Frl
          experimental knowledge based
          (Guruharsha et al., 2011)
          sax - Pvr
          experimental knowledge based
          (Guruharsha et al., 2011)
          sax - Syb
          experimental knowledge based
          (Guruharsha et al., 2011)
          sax - ZnT63C
          experimental knowledge based
          (Guruharsha et al., 2011)
          sax - babo
          anti tag coimmunoprecipitation, anti tag western blot
          (Haerry, 2010)
          sax - dpp
          protein cross-linking with a bifunctional reagent, autoradiography, anti tag coimmunoprecipitation, anti tag western blot
          (Haerry, 2010, Brummel et al., 1994)
          sax - gbb
          anti tag coimmunoprecipitation, anti tag western blot, western blot
          (Akiyama et al., 2012, Le and Wharton, 2012, Haerry, 2010)
          sax - put
          anti tag coimmunoprecipitation, autoradiography, anti tag western blot
          (Haerry, 2010, Letsou et al., 1995)
          sax - sty
          experimental knowledge based
          (Guruharsha et al., 2011)
          sax - tkv
          anti tag coimmunoprecipitation, anti tag western blot, experimental knowledge based
          (Guruharsha et al., 2011, Haerry, 2010)
          RNA-RNA
          Physical Interaction
          Assay
          References
          sax - mir-124
          quantitative reverse transcription pcr, luminiscence technology
          (Sun et al., 2012)
          sax - mir-184
          luminiscence technology, necessary binding region, immunohistochemistry
          (Iovino et al., 2009)
          Summary of Genetic Interactions
          esyN Network Diagram
          esyN Network Key:
          Suppression
          Enhancement
          View in Interactions Browser
          Please look at the allele data for full details of the genetic interactions
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          sax
          suppressible
          dpp
          (Xie et al., 1994)
          sax
          suppressible
          fuss
          (Fischer et al., 2012)
          sax
          suppressible
          gbb
          (Bangi and Wharton, 2006)
          sax
          enhanceable
          kek5
          (Evans et al., 2009)
          sax
          suppressible
          Mad
          (Waltzer and Bienz, 1999, Das et al., 1998)
          sax
          suppressible
          Med
          (Das et al., 1998)
          sax
          suppressible
          nej
          (Waltzer and Bienz, 1999)
          sax
          suppressible
          sax::Agam\sax
          (Fritsch et al., 2010)
          sax
          suppressible
          tkv
          (Brummel et al., 1994)
          sax|tkv
          suppressible
          trio
          (Ball et al., 2010)
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          anchor
          suppressible
          sax
          (Wang et al., 2018)
          CycE
          suppressible
          sax
          (Horsfield et al., 1998)
          Dd
          suppressible
          sax
          (Liu et al., 2011)
          dpp
          enhanceable
          sax
          (Twombly et al., 2009)
          dpp
          suppressible
          sax
          (Twombly et al., 2009, Bangi and Wharton, 2006)
          dpp|lolal
          suppressible
          sax
          (Quijano et al., 2016)
          frac
          suppressible
          sax
          (Miller et al., 2011)
          gbb
          suppressible
          sax
          (Le and Wharton, 2012, Fritsch et al., 2010, Bangi and Wharton, 2006, Haerry et al., 1998)
          gbb
          enhanceable
          sax
          (Bangi and Wharton, 2006)
          H
          suppressible
          sax
          (Johannes and Preiss, 2002)
          Impβ11
          suppressible
          sax
          (Higashi-Kovtun et al., 2010)
          mir-184
          suppressible
          sax
          (Iovino et al., 2009)
          Ppt1
          suppressible
          sax
          (Saja et al., 2010, Buff et al., 2007)
          Ppt1
          enhanceable
          sax
          (Saja et al., 2010)
          scw
          suppressible
          sax
          (Nguyen et al., 1998)
          spict
          suppressible
          sax
          (Wang et al., 2007)
          spin
          suppressible
          sax
          (Yuva-Aydemir et al., 2011, Sweeney and Davis, 2002)
          spin
          suppressible
          sax|tkv
          (Yuva-Aydemir et al., 2011)
          tkv
          enhanceable
          sax
          (Haerry, 2010)
          upd1
          suppressible
          sax
          (Bach et al., 2003)
          External Data
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          DroID - A comprehensive database of gene and protein interactions.
          InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
          MIST (genetic) - An integrated Molecular Interaction Database
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Pathways
          Gene Group - Pathway Membership (FlyBase)
          BMP Signaling Pathway Core Components -
          The Bone Morphogenetic Protein (BMP) signaling pathway is one of two branches of Transforming Growth Factor-β family signaling in Drosophila. The binding of a BMP family dimer to a heterodimeric serine/threonine kinase receptor complex results in the phosphorylation of Mad, a member of the Smad family. Mad forms a complex with the co-Smad, Med. This complex translocates into the nucleus and regulates the transcription of target genes in concert with other nuclear cofactors. (Adapted from FBrf0236482.)
          External Data
          Linkouts
          KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
          SignaLink - A signaling pathway resource with multi-layered regulatory networks.
          Genomic Location and Detailed Mapping Data
          Chromosome (arm)
          2R
          Recombination map
          2-57
          Cytogenetic map
          43E18-43E18
          Sequence location
          2R:7,806,484..7,810,067 [+]
          FlyBase Computed Cytological Location
          Cytogenetic map
          Evidence for location
          43E18-43E18
          Limits computationally determined from genome sequence between P{EP}CanB2EP774 and P{lacW}lin19k01207&P{lacW}rnh1k07624
          Experimentally Determined Cytological Location
          Cytogenetic map
          Notes
          References
          43E-43E
          (determined by in situ hybridisation)
          (Nellen et al., 1994, Penton et al., 1994, Xie et al., 1994)
          43E-43F
          (determined by in situ hybridisation)
          (Brummel et al., 1994)
          Experimentally Determined Recombination Data
          Location
          2-57
          (FlyBase, 2016, Schupbach and Wieschaus, 1989)
          2-57.0
          (Comeron et al., 2012)
          Left of (cM)
          Right of (cM)
          Notes
          Stocks and Reagents
          Stocks (22)
          Genomic Clones (17)
           

          Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

          cDNA Clones (65)
           

          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

          cDNA clones, fully sequences
          BDGP DGC clones
          Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          Antibody Information
          Laboratory Generated Antibodies
           
          Commercially Available Antibodies
           
          Other Information
          Relationship to Other Genes
          Source for database identify of
          Source for identity of: sax CG1891
          (Gabrielian, 1999.11)
          Source for database merge of
          Additional comments
          Other Comments
          dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
          (Kiger et al., 2003)
          Loss of function alleles of sax suppress the CycEJP mutant eye phenotype.
          (Horsfield et al., 1998)
          dpp/tkv signaling is obligatorily required, while scw/sax signaling is necessary but not sufficient for dorsal patterning in the embryo.
          (Nguyen et al., 1998)
          Mutations in dpp or its receptor sax accelerate germline stem cell loss and retard stem cell division.
          (Xie and Spradling, 1998)
          sax protein functions similarly in the anterior and posterior compartment. sax regulates salm through its role in anterior posterior patterning of the wing pouch.
          (Singer et al., 1997)
          sax protein participates in the determination of the anterior posterior margin fate in the developing wing pouch, even at the extreme anterior edge. sax and tkv interact with the same developmental pathways required for proper anterior posterior patterning of the wing.
          (Singer et al., 1997)
          grk and sax function control dpp expression in the posterior follicular epithelium during oogenesis.
          (Twombly et al., 1996)
          sax is required in the germline for oogenesis to proceed normally.
          (Twombly et al., 1996)
          There is at least partial overlap of function of the sax and tkv receptors in vivo.
          (Brummel et al., 1994)
          Specification of distinct cell fates in response to different concentrations of dpp product may be achieved combinatorially by the sax and tkv receptors. sax is required for the specification of the amnioserosa.
          (Nellen et al., 1994)
          Isolated in a PCR screen for receptor protein serine/threonine kinase candidates.
          (Penton et al., 1994)
          Mutations in sax result in a maternal effect phenotype with defects during the early stages of gastrulation.
          (Schupbach and Wieschaus, 1989)
          Origin and Etymology
          Discoverer
          Etymology
          Identification
          External Crossreferences and Linkouts ( 64 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
          modMine - A data warehouse for the modENCODE project
          SignaLink - A signaling pathway resource with multi-layered regulatory networks.
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          DPiM - Drosophila Protein interaction map
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          FLIGHT - Cell culture data for RNAi and other high-throughput technologies
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyMine - An integrated database for Drosophila genomics
          Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
          InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
          KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
          MIST (genetic) - An integrated Molecular Interaction Database
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Synonyms and Secondary IDs (10)
          Reported As
          Symbol Synonym
          Bkr43E
          (Penton, 1995.2.3)
          Brk43E
          (Penton et al., 1994)
          CG1891
          (Hosono et al., 2015, Schertel et al., 2013, Vogel et al., 2013, Ni et al., 2010.12.1, Ni et al., 2008, Morrison et al., 2000)
          SAX
          (Fan et al., 2018, Liu and Jin, 2017, Haerry, 2010, Gesualdi and Haerry, 2007, Pan et al., 2007, Hill, 1996)
          STK-B
          Sa
          (Liu et al., 2011)
          Sax
          (Follansbee et al., 2017, Li et al., 2017, Monsivais et al., 2017, Song et al., 2017, Upadhyay et al., 2017, Ma et al., 2016, Quijano et al., 2016, Bier and De Robertis, 2015, Bausek, 2013, Mbodj et al., 2013, Lim et al., 2012, Raftery and Umulis, 2012, Zoller and Schulz, 2012, Harris and Ashe, 2011, Schwank et al., 2011, Cronin et al., 2009, Kamiya et al., 2008, Pistillo and Desplan, 2007, Dudu, 2006, Umulis et al., 2006, Stathopoulos and Levine, 2005, Stathakis et al., 2000, Brown and Hartley, 1994)
          sax
          (Held et al., 2019, Huichalaf et al., 2019, Whittle and Extavour, 2019, Ameku et al., 2018, Gene Disruption Project members, 2018-, Hoyer et al., 2018, Kang et al., 2018, Lee et al., 2018, Le et al., 2018, Monedero Cobeta et al., 2018, Tseng et al., 2018, Wang et al., 2018, Houtz et al., 2017, Jeibmann et al., 2017, Song et al., 2017, Transgenic RNAi Project members, 2017-, Wells et al., 2017, Garaulet et al., 2016, Moulton and Letsou, 2016, Sarov et al., 2016, Testa and Dworkin, 2016, Ayyaz et al., 2015, Luo et al., 2015, Smendziuk et al., 2015, Bischof, 2014.10.20, Kang et al., 2014, Sopko et al., 2014, Sulkowski et al., 2014, Beckwith et al., 2013, Chauhan et al., 2013, Curtis et al., 2013, Saunders et al., 2013, Schertel et al., 2013, Hazelett et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Le and Wharton, 2012, Peterson et al., 2012, Sun et al., 2012, Dutko and Mullins, 2011, Dworkin et al., 2011, Miller et al., 2011, Pilgram et al., 2011, Quijano et al., 2011, Schwank et al., 2011, Yuva-Aydemir et al., 2011, Ballard et al., 2010, Ball et al., 2010, Ellis et al., 2010, Fritsch et al., 2010, Higashi-Kovtun et al., 2010, Kang and Bier, 2010, Saja et al., 2010, Debat et al., 2009, Evans et al., 2009, Iovino et al., 2009, Twombly et al., 2009, Miguel-Aliaga et al., 2008, Ng, 2008, Beltran et al., 2007, Buff et al., 2007, Christensen and Cook, 2007.3.22, Cordero et al., 2007, Goold and Davis, 2007, Kazama et al., 2007, Li et al., 2007, Wang et al., 2007, Bangi and Wharton, 2006, Dworkin and Gibson, 2006, Dworkin and Gibson., 2006, Li and Li, 2006, Kirilly et al., 2005, Marques, 2005, Yamashita et al., 2005, Baines, 2004, Stanyon et al., 2004, Rawson et al., 2003, Gim et al., 2001, Twombly et al., 1996, Nellen et al., 1994, Xie et al., 1994)
          Name Synonyms
          Saxophone
          (Monedero Cobeta et al., 2018, Bausek, 2013, Fischer et al., 2012, Lim et al., 2012, Peterson et al., 2012, Zoller and Schulz, 2012, Eliazer and Buszczak, 2011, Harris and Ashe, 2011, Schwank et al., 2011, Higashi-Kovtun et al., 2010, Evans et al., 2009, Pistillo and Desplan, 2007, Wang et al., 2007, Gim et al., 2001)
          saxophone
          (Ayyaz et al., 2015, Twombly et al., 2009, Miguel-Aliaga et al., 2008, Korey et al., 2007, Li et al., 2007, Dworkin and Gibson, 2006, Li and Li, 2006, Marques, 2005, Yamashita et al., 2005, Rawson et al., 2003, Basler, 1994.8.2)
          Secondary FlyBase IDs
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            References (327)