Brk43E
receptor s/t kinase - a type I Dpp receptor - necessary for the specification of the dorsal-most cell fate (amnioserosa) which requires the highest levels of Dpp activity - together with the BMP receptors Tkv and Put, Sax transduces signaling of the BMP ligands Dpp, Gbb and Scw in the embryo and in imaginal disc patterning
Please see the JBrowse view of Dmel\sax for information on other features
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Gene model reviewed during 5.40
Gene model reviewed during 5.49
3 (northern blot)
None of the polypeptides share 100% sequence identity.
570 (aa); 62 (kD predicted)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\sax using the Feature Mapper tool.
Comment: maternally deposited
GBrowse - Visual display of RNA-Seq signals
View Dmel\sax in GBrowse 22-57
2-57.0
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: sax CG1891
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
sax is required in the germline for oogenesis to proceed normally.
Isolated in a PCR screen for receptor protein serine/threonine kinase candidates.
Mutations in sax result in a maternal effect phenotype with defects during the early stages of gastrulation.