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Gene Dmel\sax

General Information
Symbol	Dmel\sax	Species	D. melanogaster
Name	saxophone	Annotation symbol	CG1891
Feature type	protein_coding_gene	FlyBase ID	FBgn0003317
Gene Model Status	Current	Stock availability	15 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map	2-57
Cytogenetic map	43E18-43E18	Sequence location	2R:3,693,989..3,697,572 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene saxophone is referred to in FlyBase by the symbol Dmel\sax (CG1891, FBgn0003317). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: transforming growth factor beta receptor activity, type I. There is experimental evidence for 15 unique biological process terms, many of which group under: single-organism developmental process; biological regulation; multicellular organism reproduction; regionalization; gamete generation; ovarian follicle cell development; regulation of developmental process; system development; cellular component organization or biogenesis; anterior/posterior axis specification; post-embryonic organ morphogenesis; negative regulation of response to stimulus. 53 alleles are reported. The phenotypes of these alleles are annotated with: organ system; adult segment; organ system subdivision; thoracic segment; synapse; external compound sense organ; imaginal precursor; extended germ band embryo; portion of tissue; non-connected developing system; epithelial furrow; spiracle; late extended germ band embryo. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine-protein kinase, active site; TGF beta receptor, GS motif; TGF-beta receptor/activin receptor, type I/II. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1633805_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of sax. Gene sequence location is 2R:3693989..3697572.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	sax: saxophone (T. Schupbach and E. Wieschaus) Maternal effect lethal, female sterile. Embryos from homozygous mothers gastrulate abnormally. The cephalic furrow is more pronounced than in wildtype. The phenotype is reminiscent of the zygotic embryonic lethal mutaton twisted gastrulaton (twg).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03	Controlled Vocabulary Terms protein binding
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 43E18-43E18   Limits computationally determined from genome sequence between P{EP}CanB2EP774 and P{lacW}lin19k01207&P{lacW}rnh1k07624
Experimentally Determined Cytological Location
Cytogenetic map Notes References 43E-43E   (determined by in situ hybridisation)   (Penton et al., 1994) 43E-43E   (determined by in situ hybridisation)   (Nellen et al., 1994) 43E-43F   (determined by in situ hybridisation)   (Brummel et al., 1994) 43E-43E   (determined by in situ hybridisation)   (Xie et al., 1994)
Experimentally Determined Recombination Data
Location	2-57 (Schupbach and Wieschaus, 1989)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\sax for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.40 Gene model reviewed during 5.49
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) sax-RA FBtr0088832  NM_078928   2415   570 sax-RB FBtr0088833  NM_165559   2716   535 sax-RC FBtr0308825  NM_001259264   2451   582
Additional Transcript Data & Comments
Reported size (kB)	3 (northern blot) (Penton et al., 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein sax-PA   FBpp0087908   64.2   570   6.80     NP_523652   AAF59189 sax-PB   FBpp0087909   60.1   535   7.33     NP_724606   AAM68863 sax-PC   FBpp0300982   65.9   582   7.73     NP_001246193   AFH07948
Additional Polypeptide Data & Comments
Reported size (kDa)	570 (aa); 62 (kD predicted) (Xie et al., 1994) 570 (aa) (Brummel et al., 1994, Nellen et al., 1994, Penton et al., 1994)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • TGF-beta receptor/activin receptor, type I/II (IPR000472) Protein kinase, catalytic domain (IPR000719) TGF beta receptor, GS motif (IPR003605) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201752   AA264360   AA390533   AA438725   AA539352   AA817404   AA817656   AA941422   AA951364   AA979340   AE013599 AAF59189   AE013599 AAM68863   AE013599 AFH07948   AI135563   AI406128   AI454997   AI455432   AI511864   AI517901   AI518717   AI519308   AI531849   AI532181   AI533389   AI533748   AI542414   AW940507   AY058363 AAL13592   BI236884   BI237151   BI242563   BI362921   BI363057   BI368722   BI372227   BI481618   BI482899   BI580093   BI637479   BI637993   BP559904   BP559905   BT099904   BT124882   BT133186   BZ286263   CO185065   CO186703   CO263566   CO275555   CO279890   CO287196   CO294370   CO299848   CO304617   CO308533   CO311851   CO311876   CO312427   EC056105   EC059042   EC064976   EC076215   EC198373   EC217729   EC217817   EC231937   EC238229   EC242429   EC245629   EC247329   EC248353   EV593454   L33476 AAA28878   L33790 AAA61946   U05209 AAA18208   U11441 AAA53242   Z70837
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q95U21 Q7JQ36 Q7JPM7 Q7JPN8 Q7JQ39
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage   organism | ubiquitous   (Brummel et al., 1994) in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism | ubiquitous   (Penton et al., 1994) embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) foregut primordium   (Fisher et al., 2012) hindgut proper primordium   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) embryonic stage 13 -- 16   dorsal pharyngeal muscle   (Fisher et al., 2012) embryonic hindgut   (Fisher et al., 2012) embryonic Malpighian tubule   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) embryonic/larval muscle system   (Fisher et al., 2012) gonad   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012)
Additional Descriptive Data
	sax transcripts are expressed ubiquitously in all tissues and at all stages of development. (Brummel et al., 1994) Uniform sax expression was observed in early embryos. While the levels decline in later embryos, expression remains ubiquitous. (Penton et al., 1994)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    318.85 Larval Midgut    160.5 Larval Hindgut    189.9 Larval Malpighian Tubules    209.5 Larval Fat Body    116.9 Larval Salivary Gland    179.7 Larval Trachea    160.175 Larval Carcass    172.75 Adult Head    206.2 Adult Eye    209.6 Adult Brain    277.6 Adult Thoracic-Abdominal Ganglion    237.7 Adult Crop    260 Adult Midgut    232 Adult Hindgut    222.5 Adult Malpighian Tubules    185.1 Adult Fat Body    202 Adult Salivary Gland    331 Adult Heart    162.6 Adult VirginFemale Spermatheca    191.1 Adult InseminatedFemale Spermatheca    197.3 Adult Ovary    562.6 Adult Testis    193.6 Adult Male Accessory Gland    288.7 Adult Carcass    204.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    318.85 Larval Midgut    160.5 Larval Hindgut    189.9 Larval Malpighian Tubules    209.5 Larval Fat Body    116.9 Larval Salivary Gland    179.7 Larval Trachea    160.175 Larval Carcass    172.75 Adult Head    206.2 Adult Eye    209.6 Adult Brain    277.6 Adult Thoracic-Abdominal Ganglion    237.7 Adult Crop    260 Adult Midgut    232 Adult Hindgut    222.5 Adult Malpighian Tubules    185.1 Adult Fat Body    202 Adult Salivary Gland    331 Adult Heart    162.6 Adult VirginFemale Spermatheca    191.1 Adult InseminatedFemale Spermatheca    197.3 Adult Ovary  (562.6) Adult Testis    193.6 Adult Male Accessory Gland    288.7 Adult Carcass    204.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    318.85 Larval Midgut    160.5 Larval Hindgut    189.9 Larval Malpighian Tubules    209.5 Larval Fat Body    116.9 Larval Salivary Gland    179.7 Larval Trachea    160.175 Larval Carcass    172.75 Adult Head    206.2 Adult Eye    209.6 Adult Brain    277.6 Adult Thoracic-Abdominal Ganglion    237.7 Adult Crop    260 Adult Midgut    232 Adult Hindgut    222.5 Adult Malpighian Tubules    185.1 Adult Fat Body    202 Adult Salivary Gland    331 Adult Heart    162.6 Adult VirginFemale Spermatheca    191.1 Adult InseminatedFemale Spermatheca    197.3 Adult Ovary    562.6 Adult Testis    193.6 Adult Male Accessory Gland    288.7 Adult Carcass    204.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    318.85 Larval Midgut    160.5 Larval Hindgut    189.9 Larval Malpighian Tubules    209.5 Larval Fat Body    116.9 Larval Salivary Gland    179.7 Larval Trachea    160.175 Larval Carcass    172.75 Adult Head    206.2 Adult Eye    209.6 Adult Brain    277.6 Adult Thoracic-Abdominal Ganglion    237.7 Adult Crop    260 Adult Midgut    232 Adult Hindgut    222.5 Adult Malpighian Tubules    185.1 Adult Fat Body    202 Adult Salivary Gland    331 Adult Heart    162.6 Adult VirginFemale Spermatheca    191.1 Adult InseminatedFemale Spermatheca    197.3 Adult Ovary    562.6 Adult Testis    193.6 Adult Male Accessory Gland    288.7 Adult Carcass    204.8 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    318.85 Larval Midgut    160.5 Larval Hindgut    189.9 Larval Malpighian Tubules    209.5 Larval Fat Body    116.9 Larval Salivary Gland    179.7 Larval Trachea    160.175 Larval Carcass    172.75 Adult Head    206.2 Adult Eye    209.6 Adult Brain    277.6 Adult Thoracic-Abdominal Ganglion    237.7 Adult Crop    260 Adult Midgut    232 Adult Hindgut    222.5 Adult Malpighian Tubules    185.1 Adult Fat Body    202 Adult Salivary Gland    331 Adult Heart    162.6 Adult VirginFemale Spermatheca    191.1 Adult InseminatedFemale Spermatheca    197.3 Adult Ovary    562.6 Adult Testis    193.6 Adult Male Accessory Gland    288.7 Adult Carcass    204.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    318.85 Larval Midgut    160.5 Larval Hindgut    189.9 Larval Malpighian Tubules    209.5 Larval Fat Body    116.9 Larval Salivary Gland    179.7 Larval Trachea    160.175 Larval Carcass    172.75 Adult Head    206.2 Adult Eye    209.6 Adult Brain    277.6 Adult Thoracic-Abdominal Ganglion    237.7 Adult Crop    260 Adult Midgut    232 Adult Hindgut    222.5 Adult Malpighian Tubules    185.1 Adult Fat Body    202 Adult Salivary Gland    331 Adult Heart    162.6 Adult VirginFemale Spermatheca    191.1 Adult InseminatedFemale Spermatheca    197.3 Adult Ovary  562.6 Adult Testis    193.6 Adult Male Accessory Gland    288.7 Adult Carcass    204.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    318.85 Larval Midgut    160.5 Larval Hindgut    189.9 Larval Malpighian Tubules    209.5 Larval Fat Body    116.9 Larval Salivary Gland    179.7 Larval Trachea    160.175 Larval Carcass    172.75 Adult Head    206.2 Adult Eye    209.6 Adult Brain    277.6 Adult Thoracic-Abdominal Ganglion    237.7 Adult Crop    260 Adult Midgut    232 Adult Hindgut    222.5 Adult Malpighian Tubules    185.1 Adult Fat Body    202 Adult Salivary Gland    331 Adult Heart    162.6 Adult VirginFemale Spermatheca    191.1 Adult InseminatedFemale Spermatheca    197.3 Adult Ovary    562.6 Adult Testis    193.6 Adult Male Accessory Gland    288.7 Adult Carcass    204.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    318.85 Larval Midgut    160.5 Larval Hindgut    189.9 Larval Malpighian Tubules    209.5 Larval Fat Body    116.9 Larval Salivary Gland    179.7 Larval Trachea    160.175 Larval Carcass    172.75 Adult Head    206.2 Adult Eye    209.6 Adult Brain    277.6 Adult Thoracic-Abdominal Ganglion    237.7 Adult Crop    260 Adult Midgut    232 Adult Hindgut    222.5 Adult Malpighian Tubules    185.1 Adult Fat Body    202 Adult Salivary Gland    331 Adult Heart    162.6 Adult VirginFemale Spermatheca    191.1 Adult InseminatedFemale Spermatheca    197.3 Adult Ovary    562.6 Adult Testis    193.6 Adult Male Accessory Gland    288.7 Adult Carcass    204.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    206.2   NA  Eye    209.6   NA  Brain    277.6   318.85  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    237.7   NA  Crop    260   160.5  Midgut    232   189.9  Hindgut    222.5   209.5  Malpighian Tubules    185.1   116.9  Fat Body    202   179.7  Salivary Gland    331   NA  Heart    162.6   160.175  Trachea    NA   NA  VirginFemale Spermatheca    191.1   NA  InseminatedFemale Spermatheca    197.3   NA  Ovary    562.6   NA  Testis    193.6   NA  Male Accessory Gland    288.7   172.75  Carcass    204.8 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    30 central nervous system, larvae L3    15 central nervous system, pupae P8    20 head, virgin 1-day female    9 head, virgin 4-day female    8 head, virgin 20-day female    10 head, mated 1-day female    8 head, mated 4-day female    10 head, mated 20-day female    10 head, mated 1-day male    13 head, mated 4-day male    18 head, mated 20-day male    23 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    14 digestive system, 1-day adult    9 digestive system, 4-day adult    10 digestive system, 20-day adult    12 fat body, larvae L3 wandering    2 fat body, white prepupae    8 fat body, pupae P8    4 carcass, larvae L3 wandering    15 carcass, 1-day adult    8 carcass, 4-day adult    8 carcass, 20-day adult    7 ovary, virgin 4-day female    53 ovary, mated 4-day female    34 testis, mated 4-day male    14 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (30) central nervous system, larvae L3    15 central nervous system, pupae P8    20 head, virgin 1-day female    9 head, virgin 4-day female    8 head, virgin 20-day female    10 head, mated 1-day female    8 head, mated 4-day female    10 head, mated 20-day female    10 head, mated 1-day male    13 head, mated 4-day male    18 head, mated 20-day male    23 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    14 digestive system, 1-day adult    9 digestive system, 4-day adult    10 digestive system, 20-day adult    12 fat body, larvae L3 wandering    2 fat body, white prepupae    8 fat body, pupae P8    4 carcass, larvae L3 wandering    15 carcass, 1-day adult    8 carcass, 4-day adult    8 carcass, 20-day adult    7 ovary, virgin 4-day female  (53) ovary, mated 4-day female  (34) testis, mated 4-day male    14 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    30 central nervous system, larvae L3    15 central nervous system, pupae P8    20 head, virgin 1-day female    9 head, virgin 4-day female    8 head, virgin 20-day female    10 head, mated 1-day female    8 head, mated 4-day female    10 head, mated 20-day female    10 head, mated 1-day male    13 head, mated 4-day male    18 head, mated 20-day male    23 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    14 digestive system, 1-day adult    9 digestive system, 4-day adult    10 digestive system, 20-day adult    12 fat body, larvae L3 wandering    2 fat body, white prepupae    8 fat body, pupae P8    4 carcass, larvae L3 wandering    15 carcass, 1-day adult    8 carcass, 4-day adult    8 carcass, 20-day adult    7 ovary, virgin 4-day female    53 ovary, mated 4-day female    34 testis, mated 4-day male    14 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    30 central nervous system, larvae L3    15 central nervous system, pupae P8    20 head, virgin 1-day female    9 head, virgin 4-day female    8 head, virgin 20-day female    10 head, mated 1-day female    8 head, mated 4-day female    10 head, mated 20-day female    10 head, mated 1-day male    13 head, mated 4-day male    18 head, mated 20-day male    23 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    14 digestive system, 1-day adult    9 digestive system, 4-day adult    10 digestive system, 20-day adult    12 fat body, larvae L3 wandering    2 fat body, white prepupae    8 fat body, pupae P8    4 carcass, larvae L3 wandering    15 carcass, 1-day adult    8 carcass, 4-day adult    8 carcass, 20-day adult    7 ovary, virgin 4-day female    53 ovary, mated 4-day female    34 testis, mated 4-day male    14 accessory gland, mated 4-day male    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    30 central nervous system, larvae L3    15 central nervous system, pupae P8    20 head, virgin 1-day female    9 head, virgin 4-day female    8 head, virgin 20-day female    10 head, mated 1-day female    8 head, mated 4-day female    10 head, mated 20-day female    10 head, mated 1-day male    13 head, mated 4-day male    18 head, mated 20-day male    23 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    14 digestive system, 1-day adult    9 digestive system, 4-day adult    10 digestive system, 20-day adult    12 fat body, larvae L3 wandering    2 fat body, white prepupae    8 fat body, pupae P8    4 carcass, larvae L3 wandering    15 carcass, 1-day adult    8 carcass, 4-day adult    8 carcass, 20-day adult    7 ovary, virgin 4-day female    53 ovary, mated 4-day female    34 testis, mated 4-day male    14 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  30 central nervous system, larvae L3    15 central nervous system, pupae P8    20 head, virgin 1-day female    9 head, virgin 4-day female    8 head, virgin 20-day female    10 head, mated 1-day female    8 head, mated 4-day female    10 head, mated 20-day female    10 head, mated 1-day male    13 head, mated 4-day male    18 head, mated 20-day male    23 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    14 digestive system, 1-day adult    9 digestive system, 4-day adult    10 digestive system, 20-day adult    12 fat body, larvae L3 wandering    2 fat body, white prepupae    8 fat body, pupae P8    4 carcass, larvae L3 wandering    15 carcass, 1-day adult    8 carcass, 4-day adult    8 carcass, 20-day adult    7 ovary, virgin 4-day female  (53) ovary, mated 4-day female  (34) testis, mated 4-day male    14 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    30 central nervous system, larvae L3    15 central nervous system, pupae P8    20 head, virgin 1-day female    9 head, virgin 4-day female    8 head, virgin 20-day female    10 head, mated 1-day female    8 head, mated 4-day female    10 head, mated 20-day female    10 head, mated 1-day male    13 head, mated 4-day male    18 head, mated 20-day male    23 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    14 digestive system, 1-day adult    9 digestive system, 4-day adult    10 digestive system, 20-day adult    12 fat body, larvae L3 wandering    2 fat body, white prepupae    8 fat body, pupae P8    4 carcass, larvae L3 wandering    15 carcass, 1-day adult    8 carcass, 4-day adult    8 carcass, 20-day adult    7 ovary, virgin 4-day female    53 ovary, mated 4-day female    34 testis, mated 4-day male    14 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    30 central nervous system, larvae L3    15 central nervous system, pupae P8    20 head, virgin 1-day female    9 head, virgin 4-day female    8 head, virgin 20-day female    10 head, mated 1-day female    8 head, mated 4-day female    10 head, mated 20-day female    10 head, mated 1-day male    13 head, mated 4-day male    18 head, mated 20-day male    23 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    14 digestive system, 1-day adult    9 digestive system, 4-day adult    10 digestive system, 20-day adult    12 fat body, larvae L3 wandering    2 fat body, white prepupae    8 fat body, pupae P8    4 carcass, larvae L3 wandering    15 carcass, 1-day adult    8 carcass, 4-day adult    8 carcass, 20-day adult    7 ovary, virgin 4-day female    53 ovary, mated 4-day female    34 testis, mated 4-day male    14 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    51 embryo 02-04hr    50 embryo 04-06hr    60 embryo 06-08hr    56 embryo 08-10hr    48 embryo 10-12hr    46 embryo 12-14hr    38 embryo 14-16hr    26 embryo 16-18hr    19 embryo 18-20hr    14 embryo 20-22hr    17 embryo 22-24hr    16 larva L1    9 larva L2    6 larva L3 12hr old    5 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    17 white prepupae new    18 white prepupae 12hr    18 white prepupae 24hr    23 pupae 2d postWPP    17 pupae 3d postWPP    14 pupae 4d postWPP    10 adult male 01day    11 adult male 05day    14 adult male 30day    14 adult female 01day    18 adult female 05day    27 adult female 30day    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (51) embryo 02-04hr  (50) embryo 04-06hr  (60) embryo 06-08hr  (56) embryo 08-10hr  (48) embryo 10-12hr  (46) embryo 12-14hr  (38) embryo 14-16hr  26 embryo 16-18hr    19 embryo 18-20hr    14 embryo 20-22hr    17 embryo 22-24hr    16 larva L1    9 larva L2    6 larva L3 12hr old    5 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    17 white prepupae new    18 white prepupae 12hr    18 white prepupae 24hr    23 pupae 2d postWPP    17 pupae 3d postWPP    14 pupae 4d postWPP    10 adult male 01day    11 adult male 05day    14 adult male 30day    14 adult female 01day    18 adult female 05day  (27) adult female 30day  (27) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    51 embryo 02-04hr    50 embryo 04-06hr    60 embryo 06-08hr    56 embryo 08-10hr    48 embryo 10-12hr    46 embryo 12-14hr    38 embryo 14-16hr    26 embryo 16-18hr    19 embryo 18-20hr    14 embryo 20-22hr    17 embryo 22-24hr    16 larva L1    9 larva L2    6 larva L3 12hr old    5 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    17 white prepupae new    18 white prepupae 12hr    18 white prepupae 24hr    23 pupae 2d postWPP    17 pupae 3d postWPP    14 pupae 4d postWPP    10 adult male 01day    11 adult male 05day    14 adult male 30day    14 adult female 01day    18 adult female 05day    27 adult female 30day    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    51 embryo 02-04hr    50 embryo 04-06hr    60 embryo 06-08hr    56 embryo 08-10hr    48 embryo 10-12hr    46 embryo 12-14hr    38 embryo 14-16hr    26 embryo 16-18hr    19 embryo 18-20hr    14 embryo 20-22hr    17 embryo 22-24hr    16 larva L1    9 larva L2    6 larva L3 12hr old    5 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    17 white prepupae new    18 white prepupae 12hr    18 white prepupae 24hr    23 pupae 2d postWPP    17 pupae 3d postWPP    14 pupae 4d postWPP    10 adult male 01day    11 adult male 05day    14 adult male 30day    14 adult female 01day    18 adult female 05day    27 adult female 30day    27 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    51 embryo 02-04hr    50 embryo 04-06hr    60 embryo 06-08hr    56 embryo 08-10hr    48 embryo 10-12hr    46 embryo 12-14hr    38 embryo 14-16hr    26 embryo 16-18hr    19 embryo 18-20hr    14 embryo 20-22hr    17 embryo 22-24hr    16 larva L1    9 larva L2    6 larva L3 12hr old    5 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    17 white prepupae new    18 white prepupae 12hr    18 white prepupae 24hr    23 pupae 2d postWPP    17 pupae 3d postWPP    14 pupae 4d postWPP    10 adult male 01day    11 adult male 05day    14 adult male 30day    14 adult female 01day    18 adult female 05day    27 adult female 30day    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (51) embryo 02-04hr  (50) embryo 04-06hr  (60) embryo 06-08hr  (56) embryo 08-10hr  (48) embryo 10-12hr  (46) embryo 12-14hr  (38) embryo 14-16hr  26 embryo 16-18hr    19 embryo 18-20hr    14 embryo 20-22hr    17 embryo 22-24hr    16 larva L1    9 larva L2    6 larva L3 12hr old    5 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    17 white prepupae new    18 white prepupae 12hr    18 white prepupae 24hr    23 pupae 2d postWPP    17 pupae 3d postWPP    14 pupae 4d postWPP    10 adult male 01day    11 adult male 05day    14 adult male 30day    14 adult female 01day    18 adult female 05day  27 adult female 30day  27 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    51 embryo 02-04hr    50 embryo 04-06hr    60 embryo 06-08hr    56 embryo 08-10hr    48 embryo 10-12hr    46 embryo 12-14hr    38 embryo 14-16hr    26 embryo 16-18hr    19 embryo 18-20hr    14 embryo 20-22hr    17 embryo 22-24hr    16 larva L1    9 larva L2    6 larva L3 12hr old    5 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    17 white prepupae new    18 white prepupae 12hr    18 white prepupae 24hr    23 pupae 2d postWPP    17 pupae 3d postWPP    14 pupae 4d postWPP    10 adult male 01day    11 adult male 05day    14 adult male 30day    14 adult female 01day    18 adult female 05day    27 adult female 30day    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    51 embryo 02-04hr    50 embryo 04-06hr    60 embryo 06-08hr    56 embryo 08-10hr    48 embryo 10-12hr    46 embryo 12-14hr    38 embryo 14-16hr    26 embryo 16-18hr    19 embryo 18-20hr    14 embryo 20-22hr    17 embryo 22-24hr    16 larva L1    9 larva L2    6 larva L3 12hr old    5 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    17 white prepupae new    18 white prepupae 12hr    18 white prepupae 24hr    23 pupae 2d postWPP    17 pupae 3d postWPP    14 pupae 4d postWPP    10 adult male 01day    11 adult male 05day    14 adult male 30day    14 adult female 01day    18 adult female 05day    27 adult female 30day    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    98 Schneider line 2 Sg4    24 embryonic 1182-4H    26 embryonic GM2    38 embryonic Kc167    42 embryonic S1    34 embryonic S3    24 leg disc CME L1    23 wing disc CME-W2    26 wing disc ML-DmD8    26 wing disc ML-DmD9    25 wing disc ML-DmD16-c3    24 wing disc ML-DmD21    27 wing disc ML-DmD32    31 haltere disc ML-DmD17-c3    35 eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1    25 CNS ML-DmBG1-c1    33 CNS ML-DmBG2-c2    49 tumorous blood cells mbn2    35 ovary fGS/OSS    29 ovary OSC    16 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (98) Schneider line 2 Sg4    24 embryonic 1182-4H  26 embryonic GM2  (38) embryonic Kc167  (42) embryonic S1  (34) embryonic S3    24 leg disc CME L1    23 wing disc CME-W2  26 wing disc ML-DmD8  26 wing disc ML-DmD9    25 wing disc ML-DmD16-c3    24 wing disc ML-DmD21  (27) wing disc ML-DmD32  (31) haltere disc ML-DmD17-c3  (35) eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1    25 CNS ML-DmBG1-c1  (33) CNS ML-DmBG2-c2  (49) tumorous blood cells mbn2  (35) ovary fGS/OSS  (29) ovary OSC    16 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    98 Schneider line 2 Sg4    24 embryonic 1182-4H    26 embryonic GM2    38 embryonic Kc167    42 embryonic S1    34 embryonic S3    24 leg disc CME L1    23 wing disc CME-W2    26 wing disc ML-DmD8    26 wing disc ML-DmD9    25 wing disc ML-DmD16-c3    24 wing disc ML-DmD21    27 wing disc ML-DmD32    31 haltere disc ML-DmD17-c3    35 eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1    25 CNS ML-DmBG1-c1    33 CNS ML-DmBG2-c2    49 tumorous blood cells mbn2    35 ovary fGS/OSS    29 ovary OSC    16 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    98 Schneider line 2 Sg4    24 embryonic 1182-4H    26 embryonic GM2    38 embryonic Kc167    42 embryonic S1    34 embryonic S3    24 leg disc CME L1    23 wing disc CME-W2    26 wing disc ML-DmD8    26 wing disc ML-DmD9    25 wing disc ML-DmD16-c3    24 wing disc ML-DmD21    27 wing disc ML-DmD32    31 haltere disc ML-DmD17-c3    35 eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1    25 CNS ML-DmBG1-c1    33 CNS ML-DmBG2-c2    49 tumorous blood cells mbn2    35 ovary fGS/OSS    29 ovary OSC    16 ovary OSS    13 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    98 Schneider line 2 Sg4    24 embryonic 1182-4H    26 embryonic GM2    38 embryonic Kc167    42 embryonic S1    34 embryonic S3    24 leg disc CME L1    23 wing disc CME-W2    26 wing disc ML-DmD8    26 wing disc ML-DmD9    25 wing disc ML-DmD16-c3    24 wing disc ML-DmD21    27 wing disc ML-DmD32    31 haltere disc ML-DmD17-c3    35 eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1    25 CNS ML-DmBG1-c1    33 CNS ML-DmBG2-c2    49 tumorous blood cells mbn2    35 ovary fGS/OSS    29 ovary OSC    16 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (98) Schneider line 2 Sg4    24 embryonic 1182-4H  26 embryonic GM2  (38) embryonic Kc167  (42) embryonic S1  (34) embryonic S3    24 leg disc CME L1    23 wing disc CME-W2  26 wing disc ML-DmD8  26 wing disc ML-DmD9    25 wing disc ML-DmD16-c3    24 wing disc ML-DmD21  27 wing disc ML-DmD32  31 haltere disc ML-DmD17-c3  (35) eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1    25 CNS ML-DmBG1-c1  (33) CNS ML-DmBG2-c2  (49) tumorous blood cells mbn2  (35) ovary fGS/OSS  29 ovary OSC    16 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    98 Schneider line 2 Sg4    24 embryonic 1182-4H    26 embryonic GM2    38 embryonic Kc167    42 embryonic S1    34 embryonic S3    24 leg disc CME L1    23 wing disc CME-W2    26 wing disc ML-DmD8    26 wing disc ML-DmD9    25 wing disc ML-DmD16-c3    24 wing disc ML-DmD21    27 wing disc ML-DmD32    31 haltere disc ML-DmD17-c3    35 eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1    25 CNS ML-DmBG1-c1    33 CNS ML-DmBG2-c2    49 tumorous blood cells mbn2    35 ovary fGS/OSS    29 ovary OSC    16 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    98 Schneider line 2 Sg4    24 embryonic 1182-4H    26 embryonic GM2    38 embryonic Kc167    42 embryonic S1    34 embryonic S3    24 leg disc CME L1    23 wing disc CME-W2    26 wing disc ML-DmD8    26 wing disc ML-DmD9    25 wing disc ML-DmD16-c3    24 wing disc ML-DmD21    27 wing disc ML-DmD32    31 haltere disc ML-DmD17-c3    35 eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1    25 CNS ML-DmBG1-c1    33 CNS ML-DmBG2-c2    49 tumorous blood cells mbn2    35 ovary fGS/OSS    29 ovary OSC    16 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    6 heat shock, 4-day adult    19 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    31 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    23 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    36 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    30 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    28 Paraquat 10 mM 48 hrs, 4-day adult    25 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    6 heat shock, 4-day adult    19 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult  (31) Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    23 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3  (36) Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (30) Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult  (28) Paraquat 10 mM 48 hrs, 4-day adult    25 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    6 heat shock, 4-day adult    19 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    31 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    23 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    36 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    30 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    28 Paraquat 10 mM 48 hrs, 4-day adult    25 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    6 heat shock, 4-day adult    19 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    31 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    23 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    36 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    30 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    28 Paraquat 10 mM 48 hrs, 4-day adult    25 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    6 heat shock, 4-day adult    19 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    31 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    23 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    36 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    30 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    28 Paraquat 10 mM 48 hrs, 4-day adult    25 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    6 heat shock, 4-day adult    19 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult  31 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    23 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3  (36) Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  30 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult  28 Paraquat 10 mM 48 hrs, 4-day adult    25 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    6 heat shock, 4-day adult    19 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    31 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    23 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    36 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    30 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    28 Paraquat 10 mM 48 hrs, 4-day adult    25 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    6 heat shock, 4-day adult    19 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    31 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    23 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    36 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    30 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    28 Paraquat 10 mM 48 hrs, 4-day adult    25 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_17 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • GH13369 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003317 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1891-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for sax Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal (with Df(2R)H23) sax1rv1 sax1rv5 sax3 sax5 sax6 saxPE5 saxPE10 lethal (with Df(2R)sax1rv2) sax3 sax4 sax5 sax6 lethal (with Df(2R)saxPE7) sax4 sax5 lethal (with Df(2R)sax-H9) sax1rv1 sax1rv5 sax3 sax4 sax5 sax6 saxPE5 saxPE10 lethal (with sax1rv1) sax3 sax5 sax6 lethal (with sax1rv5) sax3 sax4 sax5 sax6 saxP lethal (with sax3) sax1rv1 sax1rv5 sax5 sax6 lethal (with sax4) sax1rv5 saxPE5 saxPE10 lethal (with sax5) sax1rv1 sax1rv5 sax3 sax6 saxPE5 saxPE10 lethal (with sax6) sax1rv1 sax1rv5 sax3 sax5 lethal (with saxP) sax1rv5 lethal (with saxPE5) sax4 sax5 lethal (with saxPE10) sax4 sax5 lethal | embryonic stage | germline clone | non-rescuable maternal effect | recessive sax2R-73-35 sax2R-306-37 lethal | embryonic stage | maternal effect sax1 sax2 lethal | embryonic stage | maternal effect (with Df(2R)H23) sax1 lethal | embryonic stage | maternal effect (with Df(2R)P32a) sax1 lethal | embryonic stage | maternal effect (with sax1) sax2 lethal | embryonic stage | maternal effect (with sax2) sax1 lethal | embryonic stage | maternal effect | recessive sax1 sax2 lethal | larval stage saxP lethal | larval stage (with Df(2R)H23) sax4 lethal | larval stage (with sax1rv1) sax4 lethal | larval stage (with sax3) sax4 lethal | larval stage (with sax4) sax1rv1 sax3 sax5 sax6 lethal | larval stage (with sax5) sax4 lethal | larval stage (with sax6) sax4 lethal | maternal effect saxP lethal | maternal effect (with Df(2R)H23) sax1rv1 sax3 lethal | maternal effect (with Df(2R)sax-H9) sax3 lethal | maternal effect (with sax1rv1) sax2 lethal | maternal effect (with sax2) sax1rv1 lethal | maternal effect | recessive sax1 sax2 lethal | P-stage (with Df(2R)H23) sax4 lethal | P-stage (with sax1rv1) sax4 lethal | P-stage (with sax3) sax4 lethal | P-stage (with sax4) sax1rv1 sax3 sax5 sax6 lethal | P-stage (with sax5) sax4 lethal | P-stage (with sax6) sax4 lethal | recessive sax1 sax1rv1 sax4 sax5 partially lethal - majority die (with Df(2R)H23) saxP partially lethal - majority die (with Df(2R)sax1rv2) saxP partially lethal - majority die (with Df(2R)sax-H9) saxP partially lethal - majority die (with sax1rv1) saxP partially lethal - majority die (with sax3) saxP partially lethal - majority die (with sax4) saxP partially lethal - majority die (with sax5) saxP partially lethal - majority die (with sax6) saxP partially lethal - majority die (with saxP) sax1rv1 sax3 sax4 sax5 sax6 partially lethal - majority die | embryonic stage | maternal effect (with Df(2R)H23) sax2 partially lethal - majority die | embryonic stage | maternal effect (with Df(2R)P32a) sax2 viable sax2 viable, with Scer\GAL4pnr-MD237 saxGD50 saxGD2546 viable (with Df(2R)H23) sax1 sax2 viable (with Df(2R)sax1rv2) sax1 sax2 viable (with Df(2R)sax-H9) sax1 sax2 viable (with sax1) sax1rv1 sax1rv5 sax2 sax3 sax4 sax5 sax6 saxP viable (with sax1rv1) sax1 sax2 viable (with sax1rv5) sax1 sax2 viable (with sax2) sax1 sax1rv1 sax1rv5 sax3 sax4 sax5 sax6 saxP viable (with sax3) sax1 sax2 viable (with sax4) sax1 sax2 viable (with sax5) sax1 sax2 viable (with sax6) sax1 sax2 viable (with saxP) sax1 sax2 Sterility Allele female sterile sax1 female sterile | recessive sax1 sax2 Other Phenotypes Allele developmental rate defective | larval stage (with Df(2R)H23) sax3 sax4 sax5 sax6 neuroanatomy defective saxunspecified neuroanatomy defective (with Df(2R)cn7969) sax4 neuroanatomy defective (with Df(2R)sax-H9) sax4 neurophysiology defective (with sax4) sax5 neurophysiology defective (with sax5) sax4 size defective | larval stage (with Df(2R)H23) sax3 sax4 sax5 sax6 visible saxP visible, with Scer\GAL4A9 saxA-K382T.Scer\UAS saxQ263D.Scer\UAS.T:Ivir\HA1 saxScer\UAS.T:Zzzz\FLAG saxΔI.Scer\UAS visible, with Scer\GAL4ap-md544 saxScer\UAS.T:Zzzz\FLAG visible, with Scer\GAL4Bx-MS1096 saxA.Scer\UAS saxΔI.Scer\UAS visible, with Scer\GAL4en-e16E saxQ263D.Scer\UAS.cDa visible, with Scer\GAL4pnr-MD237 saxGD2546 visible, with Scer\GAL4ptc-559.1 saxΔI.Scer\UAS visible | dominant sax4 saxKG07525 visible | recessive saxQ263D.Scer\UAS.T:Ivir\HA1 visible | recessive | somatic clone sax4 sax5 wild-type sax+t8.9 Phenotype manifest in Allele 2nd posterior cell | somatic clone sax5 abdominal segment 7 | maternal effect sax1 sax2 abdominal segment 8 | maternal effect sax1 sax2 amnioproctodeal invagination | maternal effect sax1 sax2 amnioserosa sax4 amnioserosa | maternal effect sax1 sax2 saxP amnioserosa | maternal effect (with sax1) sax2 amnioserosa | maternal effect (with sax2) sax1 anterior crossvein saxP anterior crossvein, with Scer\GAL4ptc-559.1 saxΔI.Scer\UAS bouton saxunspecified bouton (with Df(2R)cn7969) sax4 brain | larval stage (with Df(2R)H23) sax6 sax3 sax4 sax5 cephalic furrow sax1 sax2 discal cell | somatic clone sax5 distal costal vein | ectopic sax4 dorsal appendage sax5 dorsal appendage | germline clone sax4 sax5 dorsal double row sax4 dorsal triple row | proximal, with Scer\GAL4A9 saxΔI.Scer\UAS egg sax5 egg | germline clone sax4 sax5 egg | maternal effect (with Df(2R)H23) sax3 egg | maternal effect (with Df(2R)sax-H9) sax3 egg chamber saxΔIC.1.hs sax1rv5 egg chamber, with Scer\GAL4hs.PB saxQ263D.Scer\UAS.cDa egg chamber | germline clone sax5 embryonic/first instar larval cuticle | maternal effect sax1 sax2 embryonic/larval dorsal branch, with Scer\GAL4btl.PS saxΔI.Scer\UAS embryonic/larval dorsal branch, with Scer\GAL4esg-p127 saxΔI.Scer\UAS embryonic/larval epidermis | dorsal sax2 embryonic/larval epidermis | dorsal | maternal effect sax1 embryonic/larval midgut | embryonic stage sax2 embryonic/larval midgut | embryonic stage | maternal effect sax1 embryonic/larval tracheal system, with Scer\GAL4btl.PS saxQ263D.Scer\UAS embryonic head saxDN.SP6 embryonic head | maternal effect sax1 sax2 extended germ band embryo sax1 sax2 extended germ band embryo | maternal effect sax1 sax2 eye saxP fat body (with Df(2R)H23) sax5 female germline stem cell saxP filzkorper saxDN.SP6 filzkorper | maternal effect sax1 sax2 germarium saxP imaginal disc sax2 imaginal disc (with Df(2R)H23) sax6 sax3 sax4 sax5 imaginal disc | maternal effect sax1 male germline stem cell | germline clone sax4 saxunspecified medial triple row | proximal, with Scer\GAL4A9 saxΔI.Scer\UAS midgut constriction 2 sax+t8.9 saxP neuromuscular junction (with Df(2R)cn7969) sax4 neuromuscular junction (with Df(2R)sax-H9) sax4 ommatidium saxP ovariole sax1rv5 ovary saxΔIC.1.hs sax5 ovary | germline clone sax4 posterior crossvein, with Scer\GAL4A9 saxΔI.Scer\UAS saxQ263D.Scer\UAS.T:Ivir\HA1 synapse saxunspecified t-bar saxunspecified trachea | larval stage (with Df(2R)H23) sax6 sax3 sax4 sax5 trichogen cell | supernumerary, with Scer\GAL4pnr-MD237 saxGD2546 trichome of the posterior wing margin sax4 triple row | ectopic sax4 ventral double row sax4 ventral triple row | proximal, with Scer\GAL4A9 saxΔI.Scer\UAS wing sax4 saxKG07525 wing, with Scer\GAL4A9 saxΔI.Scer\UAS saxQ263D.Scer\UAS.T:Ivir\HA1 saxScer\UAS.T:Zzzz\FLAG wing, with Scer\GAL4ap-md544 saxScer\UAS.T:Zzzz\FLAG wing | posterior, with Scer\GAL4en-e16E saxQ263D.Scer\UAS.cDa wing | somatic clone sax4 wing basal cell 2 | somatic clone sax5 wing blade, with Scer\GAL4Bx-MS1096 saxΔI.Scer\UAS wing cell saxQ263D.Scer\UAS.T:Ivir\HA1 wing disc, with Scer\GAL4A9 saxΔI.Scer\UAS wing vein saxQ263D.Scer\UAS.T:Ivir\HA1 wing vein, with Scer\GAL4A9 saxQ263D.Scer\UAS.T:Ivir\HA1 saxA-K382T.Scer\UAS wing vein, with Scer\GAL4Bx-MS1096 saxΔI.Scer\UAS wing vein (with Df(2R)H23) sax3 wing vein (with Df(2R)sax-H9) sax3 wing vein | cell non-autonomous | ectopic | somatic clone sax4 wing vein | ectopic sax4 saxKG07525 wing vein | ectopic, with Scer\GAL4A9 saxQ263D.Scer\UAS.T:Ivir\HA1 wing vein | ectopic, with Scer\GAL4Bx-MS1096 saxA.Scer\UAS wing vein | ectopic, with Scer\GAL4en-e16E saxQ263D.Scer\UAS.cDa wing vein | ectopic | somatic clone sax4 wing vein L2, with Scer\GAL4A9 saxΔI.Scer\UAS wing vein L4 | somatic clone sax5 wing vein L5, with Scer\GAL4A9 saxΔI.Scer\UAS
Classical Alleles ( 22 )
For All Classical Alleles Show
Allele of sax Class Mutagen Stocks Known lesion saxKG07525 P-element activity 2 -- sax4 loss of function allele, amorphic allele - genetic evidence, amorphic allele ethyl methanesulfonate 1 Yes sax5 amorphic allele - genetic evidence ethyl methanesulfonate 1 Yes saxEY04377 1 -- saxMI05726 1 -- sax1rv1 amorphic allele - genetic evidence gamma ray 0 -- saxP amorphic allele - genetic evidence, hypomorphic allele - genetic evidence P-element activity 0 Yes sax1 neomorphic allele - genetic evidence, antimorphic allele - genetic evidence, hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes sax1rv5 ethyl methanesulfonate 0 -- sax2 neomorphic allele - genetic evidence, antimorphic allele - genetic evidence, hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes sax2R-306-37 ethyl methanesulfonate 0 -- sax2R-73-35 ethyl methanesulfonate 0 -- sax3 ethyl methanesulfonate 0 Yes sax6 ethyl methanesulfonate 0 Yes sax8 0 -- saxB18 0 -- saxhrv1 loss of function allele 0 -- saxPE10 P-element activity 0 Yes saxPE5 P-element activity 0 Yes saxSL306 0 -- saxSL73 0 -- saxunspecified 0 --
Alleles Carried on Transgenic Constructs ( 31 )
For All Alleles Carried on Transgenic Constructs Show
Allele of sax Class Mutagen Stocks Known lesion saxGD2546 in vitro construct - RNAi in vitro construct - regulatory fusion 5 Yes saxGD50 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes saxHMJ02118 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes saxJF03431 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes sax+t8.7 in vitro construct - genomic fragment 0 Yes sax+t8.9 in vitro construct - genomic fragment 0 Yes saxA-K382D.Scer\UAS in vitro construct - amino acid replacement in vitro construct - regulatory fusion 0 Yes saxA-K382T.Scer\UAS in vitro construct - amino acid replacement in vitro construct - regulatory fusion 0 Yes saxA.cNa in vitro construct 0 Yes saxA.Scer\UAS.cBa in vitro construct - regulatory fusion 0 Yes saxA.Scer\UAS in vitro construct - regulatory fusion 0 Yes saxDE-Q263D.Scer\UAS.T:Ivir\HA1 in vitro construct - deletion 0 Yes saxDE.Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - deletion in vitro construct - coding region fusion 0 Yes saxDN.cNa in vitro construct 0 Yes saxDN.SP6 in vitro construct 0 Yes saxdsRNA.cSa in vitro construct - RNAi 0 Yes saxGD14397 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes saxhs.PB in vitro construct - regulatory fusion 0 Yes saxK291M in vitro construct - amino acid replacement 0 Yes saxNIG.1891R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes saxQ263D.Scer\UAS.cDa in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes saxQ263D.Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes saxQ263D.Scer\UAS in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes saxQ263D.SP6 in vitro construct - amino acid replacement 0 Yes saxQ263D.tld.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes saxScer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes saxScer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes saxUbi-p63E.PM in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes saxwt.SP6 in vitro construct 0 Yes saxΔI.Scer\UAS in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes saxΔIC.1.hs heat sensitive antimorphic allele - genetic evidence in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2)Hr-1 (Marques et al., 2003) Df(2R)BSC265 (Christensen and Cook, 2007.3.22) Df(2R)CA53 (Nellen et al., 1994) Df(2R)cn9 (Nellen et al., 1994) Df(2R)cn83c (Nellen et al., 1994) Df(2R)Exel6054 (Ryder, 2004.4.26) Df(2R)H23 (Twombly et al., 2009, Brummel et al., 1994) Df(2R)P32a (Twombly et al., 2009, Nellen et al., 1994) Df(2R)pk78s (Schupbach and Wieschaus, 1989, Schupbach and Wieschaus, 1991, Nellen et al., 1994, Bilder and Scott, 1995) Df(2R)sax-H9 (Twombly et al., 2009, Twombly et al., 1996) Df(2R)sax-H30 (Twombly et al., 2009, Brummel et al., 1994)
Not disrupted in	Df(2R)pk78k (Nellen et al., 1994) Df(2R)ST1 (Twombly et al., 2009)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD50} NA P{GD2546} NA P{GD14397} NA P{NIG.1891R} NA P{TRiP.HMJ02118} NA P{TRiP.JF03431} NA P{UAS-DE-sax.Q263D.T:HA1} NA P{UAS-sax.A.B} NA P{UAS-sax.A} NA P{UAS-sax.A-K382D} NA P{UAS-sax.A-K382T} NA P{UAS-sax.FLAG} NA P{UAS-sax.HA} NA P{UAS-sax.Q263D.D} NA P{UAS-sax.Q263D.T:HA1} NA P{UAS-sax.Q263D} NA P{UAS-sax.ΔE} NA P{UAS-sax.ΔI} NA heat-shock construct P{hs-sax} NA P{hs-tsax} NA characterization construct P{sax.8.7} NA P{sax+8.9} NA P{saxK291M} NA P{sax-Agam\sax.EX.Dmel\sax.IN} NA P{tld-sax.Q263D.T:HA1} NA P{Ubi-p63E.sax-EC.wit-IC} NA P{Ubi-p63E.wit-EC.sax-IC} NA P{Ubi-p63E-sax.M} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}saxMI05726 NA P{SUPor-P}saxKG07525 NA insertion of mobile activating element P{EPgy2}Nop17lEY04377 NA insertion of enhancer trap P{lacW}saxP No
Gene Ontology: Function, Process & Cellular Component ( 27 unique terms )
Terms Based on Experimental Evidence ( 17 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with Dad (Kamiya et al., 2008) transforming growth factor beta receptor activity, type I inferred from direct assay (Brummel et al., 1994)
Biological Process
CV term Evidence References
actin filament organization inferred from mutant phenotype (Twombly et al., 1996) anterior/posterior pattern specification, imaginal disc inferred from mutant phenotype (Singer et al., 1997) chorion-containing eggshell formation inferred from genetic interaction with tkv (Twombly et al., 1996) decapentaplegic signaling pathway inferred from genetic interaction with dpp (Nellen et al., 1994, Xie et al., 1994) inferred from mutant phenotype (Nellen et al., 1994) dorsal/ventral pattern formation inferred from genetic interaction with dpp (Nellen et al., 1994) inferred from mutant phenotype (Nellen et al., 1994) germ-line stem cell division inferred from mutant phenotype (Xie and Spradling, 1998) germ-line stem cell maintenance inferred from mutant phenotype (Xie and Spradling, 1998) imaginal disc-derived wing morphogenesis inferred from mutant phenotype (Singer et al., 1997, Dworkin and Gibson, 2006, Haerry, 2010) maternal determination of anterior/posterior axis, embryo inferred from genetic interaction with dpp (Brummel et al., 1994) inferred from mutant phenotype (Schupbach and Wieschaus, 1989) negative regulation of BMP signaling pathway inferred from mutant phenotype (Bangi and Wharton, 2006) negative regulation of transforming growth factor beta receptor signaling pathway inferred from direct assay (Twombly et al., 2009) inferred from genetic interaction with dpp (Twombly et al., 2009) oogenesis inferred from mutant phenotype (Twombly et al., 1996) ovarian follicle cell development inferred from mutant phenotype (Twombly et al., 1996) positive regulation of synaptic growth at neuromuscular junction inferred from mutant phenotype (McCabe et al., 2004) wing disc pattern formation inferred from mutant phenotype (Twombly et al., 2009)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 12 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR003605, InterPro:IPR017441 (FlyBase Curators et al., 2004-) protein kinase activity non-traceable author statement (Morrison et al., 2000) protein serine/threonine kinase activity non-traceable author statement (Padgett, 1994.1.17) transforming growth factor beta receptor activity, type I inferred from sequence or structural similarity with mouse Acvr1 (Xie et al., 1994) non-traceable author statement (Singer et al., 1997, Padgett, 1994.1.17)
Biological Process
CV term Evidence References
BMP signaling pathway traceable author statement (Letsou et al., 1995) compound eye morphogenesis non-traceable author statement (Baker, 2001) ovarian follicle cell development traceable author statement (Dobens and Raftery, 2000) ovarian nurse cell to oocyte transport traceable author statement (Buszczak and Cooley, 2000) protein phosphorylation inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR003605, InterPro:IPR008271 (FlyBase Curators et al., 2004-) non-traceable author statement (Morrison et al., 2000) transforming growth factor beta receptor signaling pathway inferred from sequence or structural similarity (Brummel et al., 1994) non-traceable author statement (Affolter et al., 2001)
Cellular Component
CV term Evidence References
integral to plasma membrane inferred from sequence or structural similarity with mouse Acvr1 (Xie et al., 1994) plasma membrane inferred from sequence or structural similarity (Brummel et al., 1994) inferred from sequence or structural similarity with mouse AcvrI (Penton et al., 1994)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
sax - CG11710 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sax - CG12004 experimental knowledge based (Guruharsha et al., 2011) sax - CG12264 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sax - CG14767 experimental knowledge based (Guruharsha et al., 2011) sax - CG31051 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sax - CG3164 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) sax - CG32138 experimental knowledge based (Guruharsha et al., 2011) sax - CG4901 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sax - CG5261 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sax - CG5447 experimental knowledge based (Guruharsha et al., 2011) sax - CG5642 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sax - CG7668 experimental knowledge based (Guruharsha et al., 2011) sax - Cdc37 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sax - Hsp23 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sax - Pvr experimental knowledge based (Guruharsha et al., 2011) sax - Rpn5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sax - Syb experimental knowledge based (Guruharsha et al., 2011) sax - Trap1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sax - Tsp29Fb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sax - ZnT63C experimental knowledge based (Guruharsha et al., 2011) sax - awd anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sax - mib2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sax - olf186-F anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sax - pUf68 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sax - pzg anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sax - ref(2)P anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sax - sty experimental knowledge based (Guruharsha et al., 2011) sax - tkv experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions sax allele Gene References sax1 dpp (Xie et al., 1994) Mef2 (Mantrova et al., 1999) os (Bach et al., 2003) tkv (Brummel et al., 1994, Twombly et al., 1996) sax2 dpp (Xie et al., 1994) H (Johannes and Preiss, 2002) os (Bach et al., 2003) sax4 gbb (Khalsa et al., 1998) os (Bach et al., 2003) spin (Sweeney and Davis, 2002) wit (McCabe et al., 2004) sax5 E(tkv)D2 (Chen et al., 1998) gbb (Khalsa et al., 1998) Mad (Chen et al., 1998) tkv (Chen et al., 1998) saxDN.cNa scw (Nguyen et al., 1998) saxDN.SP6 scw (Neul and Ferguson, 1998) saxQ263D.Scer\UAS.cDa Mad (Waltzer and Bienz, 1999) nej (Waltzer and Bienz, 1999) saxunspecified dpp (Xie et al., 1994) saxΔI.Scer\UAS scw (Nguyen et al., 1998) unspecified CycE (Horsfield et al., 1998) dpp (Bangi and Wharton, 2006, Nellen et al., 1994) gbb (Bangi and Wharton, 2006) Mad (Das et al., 1998) Med (Das et al., 1998) Ppt1 (Buff et al., 2007) tkv (Neul and Ferguson, 1998)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 61598 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0003317 DroID - A comprehensive database of gene and protein interactions. • FBgn0003317 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35731 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q7JPM7
Orthologs
OrthoDB Orthologs (75) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6PNZ2G Dipteran inclusive ortholog search EOG6WQ19R Insect inclusive ortholog search EOG6ZKHGR Arthropod inclusive ortholog search EOG6VT4CP Metazoa inclusive ortholog search EOG6JX76R
Orthologs in Drosophila Species (EOG6PNZ2G)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\sax     Drosophila simulans   Dsim\GD15359 Y   Drosophila simulans   Dsim\GD10510     Drosophila sechellia   Dsec\GM20983 Y   Drosophila erecta   Dere\GG23304 Y   Drosophila yakuba   Dyak\GE19150 Y   Drosophila ananassae   Dana\GF13635 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA15112 Y   Drosophila persimilis   Dper\GL10841 Y   Drosophila willistoni   Dwil\GK22220 Y   Drosophila virilis   Dvir\GJ21241 Y   Drosophila mojavensis   Dmoj\GI19992 Y   Drosophila grimshawi   Dgri\GH20320 Y
Orthologs in non-Drosophila Dipterans (EOG6WQ19R)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL012152   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL015125   Anopheles gambiae Malaria mosquito  Agam\AGAP007729   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ014117
Orthologs in non-Dipteran Insects (EOG6ZKHGR)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB43676   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG027266   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH13808   Camponotus floridanus Florida carpenter ant  Cflo\CFLO14362   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL16548   Linepithema humile Argentine ant  Lhum\LH10452   Pogonomyrmex barbatus Red harvester ant  Pbar\PB27374   Bombyx mori Silkmoth  Bmor\BGIBMGA009134   Pediculus humanus Human body louse  Phum\PHUM551530   Tribolium castaneum Red flour beetle  Tcas\sax
Orthologs in non-Insect Arthropods (EOG6VT4CP)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_347227   Ixodes scapularis Deer tick  Isca\ISCW011054
Orthologs in non-Arthropod Metazoa (EOG6JX76R)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\daf-1 Y Caenorhabditis elegans Nematode  Cele\sma-6 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_028066gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_016079gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_016272gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_016008gn Y Danio rerio Zebrafish  Drer\CABZ01079442.1 Y Danio rerio Zebrafish  Drer\acvr1b Y Danio rerio Zebrafish  Drer\bmpr1bb Y Danio rerio Zebrafish  Drer\acvr1l Y Danio rerio Zebrafish  Drer\acvrl1 Y Danio rerio Zebrafish  Drer\bmpr1aa Y Danio rerio Zebrafish  Drer\ENSDARG00000052142 Y Danio rerio Zebrafish  Drer\tgfbr1b Y Danio rerio Zebrafish  Drer\DKEY-24C2.2 Y Danio rerio Zebrafish  Drer\bmpr1ab Y Danio rerio Zebrafish  Drer\bmpr1ba Y Xenopus tropicalis Western clawed frog  Xtro\acvr1 Y Xenopus tropicalis Western clawed frog  Xtro\tgfbr1 Y Xenopus tropicalis Western clawed frog  Xtro\acvr1c Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000031897 Y Xenopus tropicalis Western clawed frog  Xtro\bmpr1a Y Xenopus tropicalis Western clawed frog  Xtro\acvr1b Y Xenopus tropicalis Western clawed frog  Xtro\bmpr1b Y Gallus gallus Domestic chicken  Ggal\BMPR1A Y Gallus gallus Domestic chicken  Ggal\ENSGALG00000014631 Y Gallus gallus Domestic chicken  Ggal\ACVR1C Y Gallus gallus Domestic chicken  Ggal\ChALK5 Y Gallus gallus Domestic chicken  Ggal\ACVR1 Y Gallus gallus Domestic chicken  Ggal\BMPR1B Y Mus musculus House mouse  Mmus\Acvr1b Y Mus musculus House mouse  Mmus\Bmpr1a Y Mus musculus House mouse  Mmus\Tgfbr1 Y Mus musculus House mouse  Mmus\Bmpr1b Y Rattus norvegicus Norway rat  Rnor\Tgfbr1 Y Rattus norvegicus Norway rat  Rnor\Bmpr1a Y Rattus norvegicus Norway rat  Rnor\Acvr1c Y Rattus norvegicus Norway rat  Rnor\Acvr1b Y Rattus norvegicus Norway rat  Rnor\Acvr1 Y Rattus norvegicus Norway rat  Rnor\Acvrl1 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000016289 Y Homo sapiens Human  Hsap\ACVR1 Y Homo sapiens Human  Hsap\BMPR1A Y Homo sapiens Human  Hsap\BMPR1B Y Homo sapiens Human  Hsap\ACVR1C Y Homo sapiens Human  Hsap\ENSG00000135503 Y
Human Orthologs (5)
Gene OMIM HGNC Hsap\ACVR1     Hsap\BMPR1A     Hsap\BMPR1B     Hsap\ACVR1C     Hsap\ENSG00000135503
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD15359 Drosophila sechellia Dsec\GM20983 Drosophila erecta Dere\GG23304 Drosophila yakuba Dyak\GE19150 Drosophila ananassae Dana\GF13635 Drosophila pseudoobscura pseudoobscura Dpse\GA15112 Drosophila persimilis Dper\GL10841 Drosophila willistoni Dwil\GK22220 Drosophila virilis Dvir\GJ21241 Drosophila mojavensis Dmoj\GI19992 Drosophila grimshawi Dgri\GH20320
Stocks & Reagents
Stocks Listed in FlyBase ( 15 )
Bloomington	8785 y1 w*; sax5/SM6a 36131 y1 v1; P{TRiP.JF03431}attP2 41495 y1 w*; Mi{MIC}saxMI05726 42546 y1 v1; P{TRiP.HMJ02118}attP40/CyO 14920 y1; P{SUPor-P}saxKG07525/CyO; ry506
VDRC	v42457 w1118; P{GD50}v42457 v9433 w1118 P{GD2546}v9433 v9434 w1118 P{GD2546}v9434 v46350 w1118; P{GD2546}v46350 v46356 w1118; P{GD2546}v46356 v46358 w1118; P{GD2546}v46358 v42456 w1118; P{GD50}v42456/TM3
	More stocks available...
Genomic Clones ( 1 )
	BACR04B09 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 65 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH13369 GM27691
Other clones	DPiM_GH13369 FI19445 MIP17172
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH26333 LD02831 LD04978 LD08041 LD08757 LD13065 LD17446 LD22672 LD25554 LD31787 LD33851 LD38413 LD38846 LD43039 LD43410 RE33013 RE33324 RE39940 RE47612 RE47772 RE54739 RE59136 RE64194 RE65708 RE74230 SD03130 SD03577 SD05181 SD05706 SD08729 SD19517 SD20240
Other clones	28498 50958 76589 101776 103910 104497 155906 CK01.25A.F3 CK01.29A.B10 CK01.100B.D8 CK01.141C.D3 Dmel_neb_012560_0682_3001 EC29260 EC056105 EK022322 EK065204 EK088934 EK117914 EK136323 EK176734 EK206749 EK227010 EK227120 EK228742 EK245302 EK258627 FGM323E12 LD24180
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0003317 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35731
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: sax CG1891 (Gabrielian, 1999.11)
Source for database merge of
Additional comments
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Loss of function alleles of sax suppress the CycEJP mutant eye phenotype. (Horsfield et al., 1998) dpp/tkv signaling is obligatorily required, while scw/sax signaling is necessary but not sufficient for dorsal patterning in the embryo. (Nguyen et al., 1998) Mutations in dpp or its receptor sax accelerate germline stem cell loss and retard stem cell division. (Xie and Spradling, 1998) sax protein functions similarly in the anterior and posterior compartment. sax regulates salm through its role in anterior posterior patterning of the wing pouch. (Singer et al., 1997) sax protein participates in the determination of the anterior posterior margin fate in the developing wing pouch, even at the extreme anterior edge. sax and tkv interact with the same developmental pathways required for proper anterior posterior patterning of the wing. (Singer et al., 1997) grk and sax function control dpp expression in the posterior follicular epithelium during oogenesis. (Twombly et al., 1996) sax is required in the germline for oogenesis to proceed normally. (Twombly et al., 1996) There is at least partial overlap of function of the sax and tkv receptors in vivo. (Brummel et al., 1994) Specification of distinct cell fates in response to different concentrations of dpp product may be achieved combinatorially by the sax and tkv receptors. sax is required for the specification of the amnioserosa. (Nellen et al., 1994) Isolated in a PCR screen for receptor protein serine/threonine kinase candidates. (Penton et al., 1994) Mutations in sax result in a maternal effect phenotype with defects during the early stages of gastrulation. (Schupbach and Wieschaus, 1989)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078928 NM_165559 NM_001259264 RefSeq (Proteins) • NP_523652 NP_724606 NP_001246193 DDBJ / EMBL / GenBank • AAA18208 AAA28878 AAA53242 AAA61946 AAF59189 AAL13592 AAM68863 AFH07948 AI135563 AW940507 AY058363 BZ286263 L33476 L33790 U05209 U11441 Z70837 Entrez Gene - A searchable database of RefSeq genes. • 35731 UniProtKB/TrEMBL • Q7JPM7 Q7JPN8 Q7JQ36 Q7JQ39 Q95U21
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • TGF-beta receptor/activin receptor, type I/II (IPR000472) Protein kinase, catalytic domain (IPR000719) TGF beta receptor, GS motif (IPR003605) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH13369
Linkouts
	BioGRID - A database of protein and genetic interactions • 61598 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0003317 DroID - A comprehensive database of gene and protein interactions. • FBgn0003317 DRSC - Results from RNAi screens. • FBgn0003317 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003317 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1891-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0003317 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35731 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /gene/saxophon.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35731 modMine - Data generated by the modENCODE project. • FBgn0003317 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q7JPM7
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	Bkr43E (Penton, 1995.2.3) Brk43E (Penton et al., 1994, ) CG1891 (Ni et al., 2008, Morrison et al., 2000, Ni et al., 2010.12.1) Sa (Liu et al., 2011) sax (Dworkin and Gibson., 2006, Nellen et al., 1994, Sun et al., 2012, Bangi and Wharton, 2006, Christensen and Cook, 2007.3.22, Dworkin and Gibson, 2006, Ball et al., 2010, Kirilly et al., 2005, Rawson et al., 2003, Xie et al., 1994, Twombly et al., 1996, Kang and Bier, 2010, Yuva-Aydemir et al., 2011, Buff et al., 2007, Baines, 2004, Hazelett et al., 2012, Wang et al., 2007, Yamashita et al., 2005, Marques, 2005, Miller et al., 2011, Debat et al., 2009, Ng, 2008, Li et al., 2007, Goold and Davis, 2007, Miguel-Aliaga et al., 2008, Li and Li, 2006, Evans et al., 2009, Iovino et al., 2009, Cordero et al., 2007, Fritsch et al., 2010, Twombly et al., 2009, Gim et al., 2001, Ballard et al., 2010, Ellis et al., 2010, Higashi-Kovtun et al., 2010, Saja et al., 2010, Beltran et al., 2007, Pilgram et al., 2011, Dworkin et al., 2011, Kazama et al., 2007, Peterson et al., 2012, Le and Wharton, 2012, Quijano et al., 2011, Japanese National Institute of Genetics, 2012.5.21) Sax (Stathakis et al., 2000, Brown and Hartley, 1994, Pistillo and Desplan, 2007, Dudu, 2006, Umulis et al., 2006, Stathopoulos and Levine, 2005, Kamiya et al., 2008, Cronin et al., 2009) SAX (Gesualdi and Haerry, 2007, Haerry, 2010, Hill, 1996) STK-B
Name Synonym	saxophone (Basler, 1994.8.2, Korey et al., 2007, Dworkin and Gibson, 2006, Rawson et al., 2003, Yamashita et al., 2005, Marques, 2005, Li et al., 2007, Miguel-Aliaga et al., 2008, Li and Li, 2006, Twombly et al., 2009) Saxophone (Pistillo and Desplan, 2007, Wang et al., 2007, Evans et al., 2009, Gim et al., 2001, Higashi-Kovtun et al., 2010, Fischer et al., 2012, Peterson et al., 2012)
Secondary FlyBase IDs
References ( 251 )
Generate a list of	All references relating to this gene ( 251 )
List References by type	Research paper  ( 120 ) Supplementary material  ( 12 ) Review  ( 57 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 42 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 3 ) Stock list  ( 1 ) Curated genome annotation  ( 3 ) Website  ( 1 ) Conference report  ( 1 )
Recent research papers ( 13 )
	Gorostiza and Ceriani, 2013, J. Neurosci. 33(2): 687--696 Retrograde bone morphogenetic protein signaling shapes a key circadian pacemaker circuit. [FBrf0220479] Fischer et al., 2012, PLoS ONE 7(8): e42349 fussel (fuss) - A Negative Regulator of BMP Signaling in Drosophila melanogaster. [FBrf0219160] Hazelett et al., 2012, G3 (Bethesda) 2(7): 789--802 Comparison of Parallel High-Throughput RNA Sequencing Between Knockout of TDP-43 and Its Overexpression Reveals Primarily Nonreciprocal and Nonoverlapping Gene Expression Changes in the Central Nervous System of Drosophila. [FBrf0219102] Le and Wharton, 2012, Dev. Dyn. 241(1): 200--214 Hyperactive BMP signaling induced by ALK2(R206H) requires type II receptor function in a Drosophila model for classic fibrodysplasia ossificans progressiva. [FBrf0217004] Peterson et al., 2012, PLoS ONE 7(5): e36548 R-smad competition controls activin receptor output in Drosophila. [FBrf0218205] Sun et al., 2012, PLoS Genet. 8(2): e1002515 Neurophysiological Defects and Neuronal Gene Deregulation in Drosophila mir-124 Mutants. [FBrf0217508] Dworkin et al., 2011, Genetics 187(4): 1171--1184 The effects of weak genetic perturbations on the transcriptome of the wing imaginal disc and its association with wing shape in Drosophila melanogaster. [FBrf0214376] Liu et al., 2011, Dev. Growth Differ. 53(6): 822--841 Negative modulation of bone morphogenetic protein signaling by Dullard during wing vein formation in Drosophila. [FBrf0214664] Miller et al., 2011, J. Neurosci. 31(14): 5335--5347 Drosophila mmp2 regulates the matrix molecule faulty attraction (frac) to promote motor axon targeting in Drosophila. [FBrf0213409] Pilgram et al., 2011, J. Neurosci. 31(2): 492--500 The RhoGAP crossveinless-c Interacts with Dystrophin and Is Required for Synaptic Homeostasis at the Drosophila Neuromuscular Junction. [FBrf0212767] Quijano et al., 2011, Genetics 189(3): 809--824 Wg Signaling via Zw3 and Mad Restricts Self-Renewal of Sensory Organ Precursor Cells in Drosophila. [FBrf0216675] Schwank et al., 2011, PLoS Biol. 9(7): e1001111 Formation of the long range dpp morphogen gradient. [FBrf0214609] Yuva-Aydemir et al., 2011, J. Neurosci. 31(19): 7005--7015 Spinster Controls Dpp Signaling during Glial Migration in the Drosophila Eye. [FBrf0213705] Show all research papers ...
Recent reviews ( 1 )
	Broadie et al., 2011, Dev. Neurobiol. 71(11): 1102--1130 Extracellular matrix and its receptors in drosophila neural development. [FBrf0216377] Show all reviews ...