dRING, dRING1, Ring, Sex comb extra, RING1
Polycomb group - protein ubiquitination - a member of a protein complex, termed PRC1 (Polycomb repressive complex 1) - monoubiquitylates histone H2A, an activity thought to be crucial for repression by PRC1-type complexes
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Gene model reviewed during 5.44
There is only one protein coding transcript and one polypeptide associated with this gene
Interacts with ORD. Component of PRC1 complex, which contains many PcG proteins like Pc, ph, Scm, Psc, Sce and also chromatin remodeling proteins such as histone deacetylases. This complex is distinct from the Esc/E(z) complex, at least composed of esc, E(z), Su(z)12, Rpd3 and Caf1. The two complexes however cooperate and interact together during the first 3 hours of development to establish PcG silencing.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Sce using the Feature Mapper tool.
Comment: maternal component at stage 5
Comment: NOT expressed in epidermis
Comment: expressed ONLY in CNS
Comment: Ubiquitous Sce expression observed in all imaginal discs.
Comment: maternally deposited
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: Ubiquitous Sce expression observed in all imaginal discs.
GBrowse - Visual display of RNA-Seq signals
View Dmel\Sce in GBrowse 23-94
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Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Source for merge of: Sce Ring
DNA-protein interactions: genome-wide binding profile assayed for Sce protein in Kc167 cells; see Chromatin_types_NKI collection report. Individual protein-binding experiments listed under "Samples" at GEO_GSE22069 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE22069).
Gene expression is increased in response to the presence of two copies of Scer\GAL4hs.PB.
Sce is required for normal neuroblast survival and proliferation in postembryonic central nervous system development.
Silencing activity of the iab-7PRE in the bithorax complex is dependent upon proteins from the Polycomb group.
In an effort to subdivide the Pc-group genes functionally, the phenotypes of adult flies heterozygous for every pairwise combination of Pc-group mutation were examined. Asx, Pc, Pcl, Psc, Scm and Sce have similar functions in some imaginal tissues. Most duplications of Pc-group genes neither exhibit anterior transformations nor suppress the extra sex comb phenotype of Pc-group mutations, suggesting that not all Pc-group genes behave as predicted by the mass action model.
Mutations of genes in the polycomb group (esc, E(z), Pc, ph-p, ph-d, Scm, Pcl, Sce, Asx, Psc, pho and Antp) cause abnormal segmental development due to the ectopic expression of abd-A and Abd-B. Embryos lacking both maternal and zygotic Sce product were generated to determine abd-A and Abd-B expression patterns.
The Pc group genes are negative regulators of homeotic genes.
Pole cell transplantation techniques demonstrate that Sce is maternally expressed and is required for normal BXC expression during embryogenesis.