• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • CytoSearch
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Downloads:
  • Precomputed files
  • Archived data
  • Releases (FTP)
  • Genomes (FTP)
  • AAA data (FTP)
  • Lists:
  • Transposons (Dmel)
  • Transposons (other)
  • Vectors & Constructs
  • Anatomical Terms
  • Map Conversion
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Other links:
  • BDGP
  • DGRC
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\Sce

General Information
Symbol	Dmel\Sce	Species	D. melanogaster
Name	Sex combs extra	Annotation symbol	CG5595
Feature type	protein_coding_gene	FlyBase ID	FBgn0003330
Gene Model Status	Current	Stock availability	6 publicly available
Also Known As	dRing, dRING1, Ring, RING1
Genomic Location
Chromosome (arm)	3R	Recombination map	3-92
Cytogenetic map	98B1-98B1	Sequence location	3R:23,506,126..23,507,746 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Sex combs extra is referred to in FlyBase by the symbol Dmel\Sce (CG5595, FBgn0003330). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence that it is involved in the biological process: germarium-derived female germ-line cyst encapsulation; ovarian follicle cell stalk formation; sex comb development; multicellular organismal development; chromatin silencing; sister chromatid cohesion; neurogenesis. 12 alleles are reported. The phenotypes of these alleles are annotated with: larval abdominal segment 7; metathoracic ventral denticle belt; adult thorax; abdominal 4 ventral denticle belt; prothoracic ventral denticle belt; mesothoracic tergum; embryonic thoracic segment; mesothoracic ventral denticle belt; embryonic abdominal segment; denticle belt. It has one annotated transcript and one annotated polypeptide. Protein features are: Zinc finger, C3HC4 RING-type; Zinc finger, RING-type; Zinc finger, RING-type, conserved site; Zinc finger, RING/FYVE/PHD-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1627898_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Sce. Gene sequence location is 3R:23506126..23507746.
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	Sce: Sex combs extra A dominant enhancer of Mcp in the BXC. Sce/Sce zygotes from Sce/+ mothers die as first instar larvae with weak posteriorly directed transformations, i.e., A7 displays some A8 characteristics. Heterozygous offspring normal. Sce/Sce embryos from clones of homozygous oocytes produced by pole-cell transplantation display extreme posteriorly directed segmental transformation. Ventral setal belts of all abdominal and thoracic segments transformed toward A8; head involution blocked; abdominal type denticle belts also found anterior to T1 in the presumptive labial and maxillary segments; in addition an extensive belt of abdominal denticles of unknown derivation forms on the anterodorsal surface of the embryo. Keilin's organs and ventral pits suppressed in thoracic segments; wart-like sensilla normally found in A8 formed anteriorally as far as A2. Tracheal branches in A1-7 resemble those normally found more posteriorly. Sce/+ offspring from homozygous germ line clones in the mothers may survive to adulthood or die as pharate adults; they show patches of tissue transformed toward A8.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Controlled Vocabulary Terms nucleus Unknown in situ Alleles Sce[Scer\UAS.T:Zzzz\FLAG] Sce[Y307A.Scer\UAS.T:Zzzz\FLAG] References Wang et al., 2010, Structure 18(8): 966--975 Sequence features HFA16825 BKN29179 Transgenic Constructs M{UAS-Sce.Y307A-FLAG} M{UAS-Sce-FLAG.WT}
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 98B1-98B1   Limits computationally determined from genome sequence between P{PZ}sda03884 and P{PZ}btzrL203
Experimentally Determined Cytological Location
Cytogenetic map Notes References 98A-98A   (determined by in situ hybridisation)   (Gorfinkiel et al., 2004) 98A-99D     (Dyer, 1997.9.9) 98B-98B   Clones hybridise to both 98B and 99C, probably as a result of a repeated sequence. The hybridisation to 98B is very slightly stronger than to 99C, though both are strong. (determined by in situ hybridisation) 99C (determined by in situ hybridisation)   (Brookman, 1998.5.13)
Experimentally Determined Recombination Data
Location	3-92
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Sce for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Sce-RA FBtr0085245  NM_058161   1564   435
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Sce-PA   FBpp0084614   47.3   435   7.14     NP_477509   AAF56737
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, RING-type (IPR001841) Zinc finger, C3HC4 RING-type (IPR018957) Zinc finger, RING-type, conserved site (IPR017907) Zinc finger, RING/FYVE/PHD-type (IPR013083)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202848   AA263407   AA390843   AA392419   AA539902   AA540165   AA820372   AA941673   AA941774   AE014297 AAF56737   AC007818   AI455406   AI456123   AI512175   AI515921   AI516326   AI519376   AJ001514 CAA04797   AY058535 AAL13764   BI162361   BI162362   BI172588   BI227649   BI232231   BI242955   BI362763   BI365604   BI579128   BI579709   BI579981   BI583734   BI584833   BI586727   BI625670   BX016922   BX024870   BX026866   BX043461   CK657347   CO189328   CO296566   CO318142   EC075746   EC078222   EC229782   EC257476   EV580437   GH784713   GH792857   GH794515   GH804035   GH807588   GH814796   GH824766   GH837124   GH838031   GH841981   GH849676   GH853010   GH853205   GH854583   GH858058   GH863087   GH866350   GH869467   GH888283   GH889671   GH896523   GH898088   GH922943   GH928697   GH932582   GH933186
UniProtKB/Swiss-Prot	Q9VB08
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 11   organism | ubiquitous   (Gorfinkiel et al., 2004) embryonic stage 5 -- 11   organism   (Gorfinkiel et al., 2004) Comment:maternal component at stage 5 embryonic stage 13   ventral nerve cord primordium   (Gorfinkiel et al., 2004) Comment:NOT expressed in epidermis embryonic stage 15   central nervous system   (Gorfinkiel et al., 2004) Comment:expressed ONLY in CNS embryonic stage 15 -- 16   central nervous system   (Gorfinkiel et al., 2004) larval stage   imaginal disc   (Gorfinkiel et al., 2004) Comment:Ubiquitous Sce expression observed in all imaginal discs. imaginal disc | ubiquitous   (Gorfinkiel et al., 2004)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 11   organism | ubiquitous   (Gorfinkiel et al., 2004) embryonic stage 5 -- 11   organism   (Gorfinkiel et al., 2004) embryonic stage 13   ventral nerve cord primordium   (Gorfinkiel et al., 2004) embryonic stage 14   epidermis   (Gorfinkiel et al., 2004) embryonic stage 15 -- 16   central nervous system   (Gorfinkiel et al., 2004) embryonic head epidermis   (Gorfinkiel et al., 2004) larval stage   imaginal disc   (Gorfinkiel et al., 2004) Comment:Ubiquitous Sce expression observed in all imaginal discs. western blot Stage Tissue/Position (including subcellular localization) Reference larval stage   imaginal disc   (Gorfinkiel et al., 2004)
Additional Descriptive Data
	At stage 14 of development, Sce protein but not mRNA is observed in the epidermis, suggesting that Sce translation or stability might be spatially regulated. (Gorfinkiel et al., 2004)
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0003330    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0003330 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0003330 expression level Developmental Stage   Expression Level embryo 00-02hr    4556 embryo 02-04hr    6269 embryo 04-06hr    4692 embryo 06-08hr    4937 embryo 08-10hr    4593 embryo 10-12hr    4963 embryo 12-14hr    2573 embryo 14-16hr    3215 embryo 16-18hr    2146 embryo 18-20hr    1684 embryo 20-22hr    1756 embryo 22-24hr    1390 larva L1    1108 larva L2    901 larva L3 12hr old    631 larva L3 puffstage 1-2    709 larva L3 puffstage 3-6    1068 larva L3 puffstage 7-9    1152 white prepupae new    1229 white prepupae 12hr    1373 white prepupae 24hr    1762 pupae 2d postWPP    1354 pupae 3d postWPP    814 pupae 4d postWPP    686 adult male 01day    616 adult male 05day    801 adult male 30day    939 adult female 01day    1363 adult female 05day    1811 adult female 30day    2065 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4556) embryo 02-04hr  (6269) embryo 04-06hr  (4692) embryo 06-08hr  (4937) embryo 08-10hr  (4593) embryo 10-12hr  (4963) embryo 12-14hr  (2573) embryo 14-16hr  (3215) embryo 16-18hr  (2146) embryo 18-20hr  (1684) embryo 20-22hr  (1756) embryo 22-24hr  (1390) larva L1  (1108) larva L2  (901) larva L3 12hr old  (631) larva L3 puffstage 1-2  (709) larva L3 puffstage 3-6  (1068) larva L3 puffstage 7-9  (1152) white prepupae new  (1229) white prepupae 12hr  (1373) white prepupae 24hr  (1762) pupae 2d postWPP  (1354) pupae 3d postWPP  (814) pupae 4d postWPP  (686) adult male 01day  (616) adult male 05day  (801) adult male 30day  (939) adult female 01day  (1363) adult female 05day  (1811) adult female 30day  (2065) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4556) embryo 02-04hr  (6269) embryo 04-06hr  (4692) embryo 06-08hr  (4937) embryo 08-10hr  (4593) embryo 10-12hr  (4963) embryo 12-14hr  (2573) embryo 14-16hr  (3215) embryo 16-18hr  (2146) embryo 18-20hr  (1684) embryo 20-22hr  (1756) embryo 22-24hr    1390 larva L1    1108 larva L2    901 larva L3 12hr old    631 larva L3 puffstage 1-2    709 larva L3 puffstage 3-6    1068 larva L3 puffstage 7-9    1152 white prepupae new    1229 white prepupae 12hr    1373 white prepupae 24hr  (1762) pupae 2d postWPP    1354 pupae 3d postWPP    814 pupae 4d postWPP    686 adult male 01day    616 adult male 05day    801 adult male 30day    939 adult female 01day    1363 adult female 05day  (1811) adult female 30day  (2065) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4556 embryo 02-04hr    6269 embryo 04-06hr    4692 embryo 06-08hr    4937 embryo 08-10hr    4593 embryo 10-12hr    4963 embryo 12-14hr    2573 embryo 14-16hr    3215 embryo 16-18hr    2146 embryo 18-20hr    1684 embryo 20-22hr    1756 embryo 22-24hr    1390 larva L1    1108 larva L2    901 larva L3 12hr old    631 larva L3 puffstage 1-2    709 larva L3 puffstage 3-6    1068 larva L3 puffstage 7-9    1152 white prepupae new    1229 white prepupae 12hr    1373 white prepupae 24hr    1762 pupae 2d postWPP    1354 pupae 3d postWPP    814 pupae 4d postWPP    686 adult male 01day    616 adult male 05day    801 adult male 30day    939 adult female 01day    1363 adult female 05day    1811 adult female 30day    2065 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4556 embryo 02-04hr    6269 embryo 04-06hr    4692 embryo 06-08hr    4937 embryo 08-10hr    4593 embryo 10-12hr    4963 embryo 12-14hr    2573 embryo 14-16hr    3215 embryo 16-18hr    2146 embryo 18-20hr    1684 embryo 20-22hr    1756 embryo 22-24hr    1390 larva L1    1108 larva L2    901 larva L3 12hr old    631 larva L3 puffstage 1-2    709 larva L3 puffstage 3-6    1068 larva L3 puffstage 7-9    1152 white prepupae new    1229 white prepupae 12hr    1373 white prepupae 24hr    1762 pupae 2d postWPP    1354 pupae 3d postWPP    814 pupae 4d postWPP    686 adult male 01day    616 adult male 05day    801 adult male 30day    939 adult female 01day    1363 adult female 05day    1811 adult female 30day    2065 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0003330 expression level Developmental Stage   Expression Level embryo 00-02hr    4556 embryo 02-04hr    6269 embryo 04-06hr    4692 embryo 06-08hr    4937 embryo 08-10hr    4593 embryo 10-12hr    4963 embryo 12-14hr    2573 embryo 14-16hr    3215 embryo 16-18hr    2146 embryo 18-20hr    1684 embryo 20-22hr    1756 embryo 22-24hr    1390 larva L1    1108 larva L2    901 larva L3 12hr old    631 larva L3 puffstage 1-2    709 larva L3 puffstage 3-6    1068 larva L3 puffstage 7-9    1152 white prepupae new    1229 white prepupae 12hr    1373 white prepupae 24hr    1762 pupae 2d postWPP    1354 pupae 3d postWPP    814 pupae 4d postWPP    686 adult male 01day    616 adult male 05day    801 adult male 30day    939 adult female 01day    1363 adult female 05day    1811 adult female 30day    2065 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4556) embryo 02-04hr  (6269) embryo 04-06hr  (4692) embryo 06-08hr  (4937) embryo 08-10hr  (4593) embryo 10-12hr  (4963) embryo 12-14hr  (2573) embryo 14-16hr  (3215) embryo 16-18hr  (2146) embryo 18-20hr  (1684) embryo 20-22hr  (1756) embryo 22-24hr  (1390) larva L1  (1108) larva L2  (901) larva L3 12hr old  (631) larva L3 puffstage 1-2  (709) larva L3 puffstage 3-6  (1068) larva L3 puffstage 7-9  (1152) white prepupae new  (1229) white prepupae 12hr  (1373) white prepupae 24hr  (1762) pupae 2d postWPP  (1354) pupae 3d postWPP  (814) pupae 4d postWPP  (686) adult male 01day  (616) adult male 05day  (801) adult male 30day  (939) adult female 01day  (1363) adult female 05day  (1811) adult female 30day  (2065) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4556) embryo 02-04hr  (6269) embryo 04-06hr  (4692) embryo 06-08hr  (4937) embryo 08-10hr  (4593) embryo 10-12hr  (4963) embryo 12-14hr  (2573) embryo 14-16hr  (3215) embryo 16-18hr  2146 embryo 18-20hr  1684 embryo 20-22hr  1756 embryo 22-24hr    1390 larva L1    1108 larva L2    901 larva L3 12hr old    631 larva L3 puffstage 1-2    709 larva L3 puffstage 3-6    1068 larva L3 puffstage 7-9    1152 white prepupae new    1229 white prepupae 12hr    1373 white prepupae 24hr  1762 pupae 2d postWPP    1354 pupae 3d postWPP    814 pupae 4d postWPP    686 adult male 01day    616 adult male 05day    801 adult male 30day    939 adult female 01day    1363 adult female 05day  1811 adult female 30day  2065 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4556 embryo 02-04hr    6269 embryo 04-06hr    4692 embryo 06-08hr    4937 embryo 08-10hr    4593 embryo 10-12hr    4963 embryo 12-14hr    2573 embryo 14-16hr    3215 embryo 16-18hr    2146 embryo 18-20hr    1684 embryo 20-22hr    1756 embryo 22-24hr    1390 larva L1    1108 larva L2    901 larva L3 12hr old    631 larva L3 puffstage 1-2    709 larva L3 puffstage 3-6    1068 larva L3 puffstage 7-9    1152 white prepupae new    1229 white prepupae 12hr    1373 white prepupae 24hr    1762 pupae 2d postWPP    1354 pupae 3d postWPP    814 pupae 4d postWPP    686 adult male 01day    616 adult male 05day    801 adult male 30day    939 adult female 01day    1363 adult female 05day    1811 adult female 30day    2065 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4556 embryo 02-04hr    6269 embryo 04-06hr    4692 embryo 06-08hr    4937 embryo 08-10hr    4593 embryo 10-12hr    4963 embryo 12-14hr    2573 embryo 14-16hr    3215 embryo 16-18hr    2146 embryo 18-20hr    1684 embryo 20-22hr    1756 embryo 22-24hr    1390 larva L1    1108 larva L2    901 larva L3 12hr old    631 larva L3 puffstage 1-2    709 larva L3 puffstage 3-6    1068 larva L3 puffstage 7-9    1152 white prepupae new    1229 white prepupae 12hr    1373 white prepupae 24hr    1762 pupae 2d postWPP    1354 pupae 3d postWPP    814 pupae 4d postWPP    686 adult male 01day    616 adult male 05day    801 adult male 30day    939 adult female 01day    1363 adult female 05day    1811 adult female 30day    2065 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0003330    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0003330 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0003330 expression level Tissue   Expression Level Larval Central Nervous System    169.15 Larval Midgut    30.7 Larval Hindgut    63.1 Larval Malpighian Tubules    39.4 Larval Fat Body    37.7 Larval Salivary Gland    73.5 Larval Trachea    60.3 Larval Carcass    43.925 Adult Head    55.4 Adult Eye    57.975 Adult Brain    122.4 Adult Thoracic-Abdominal Ganglion    79.3 Adult Crop    47.9 Adult Midgut    37.7 Adult Hindgut    50.8 Adult Malpighian Tubules    26.7 Adult Fat Body    23.9 Adult Salivary Gland    61.8 Adult Heart    24.85 Adult VirginFemale Spermatheca    26.4 Adult InseminatedFemale Spermatheca    27.4 Adult Ovary    149.1 Adult Testis    40.4 Adult Male Accessory Gland    41.7 Adult Carcass    30.4 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    169.15 Larval Midgut    30.7 Larval Hindgut    63.1 Larval Malpighian Tubules    39.4 Larval Fat Body    37.7 Larval Salivary Gland    73.5 Larval Trachea    60.3 Larval Carcass    43.925 Adult Head    55.4 Adult Eye    57.975 Adult Brain    122.4 Adult Thoracic-Abdominal Ganglion    79.3 Adult Crop    47.9 Adult Midgut    37.7 Adult Hindgut    50.8 Adult Malpighian Tubules    26.7 Adult Fat Body    23.9 Adult Salivary Gland    61.8 Adult Heart    24.85 Adult VirginFemale Spermatheca    26.4 Adult InseminatedFemale Spermatheca    27.4 Adult Ovary    149.1 Adult Testis    40.4 Adult Male Accessory Gland    41.7 Adult Carcass    30.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    169.15 Larval Midgut    30.7 Larval Hindgut    63.1 Larval Malpighian Tubules    39.4 Larval Fat Body    37.7 Larval Salivary Gland    73.5 Larval Trachea    60.3 Larval Carcass    43.925 Adult Head    55.4 Adult Eye    57.975 Adult Brain    122.4 Adult Thoracic-Abdominal Ganglion    79.3 Adult Crop    47.9 Adult Midgut    37.7 Adult Hindgut    50.8 Adult Malpighian Tubules    26.7 Adult Fat Body    23.9 Adult Salivary Gland    61.8 Adult Heart    24.85 Adult VirginFemale Spermatheca    26.4 Adult InseminatedFemale Spermatheca    27.4 Adult Ovary    149.1 Adult Testis    40.4 Adult Male Accessory Gland    41.7 Adult Carcass    30.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    169.15 Larval Midgut    30.7 Larval Hindgut    63.1 Larval Malpighian Tubules    39.4 Larval Fat Body    37.7 Larval Salivary Gland    73.5 Larval Trachea    60.3 Larval Carcass    43.925 Adult Head    55.4 Adult Eye    57.975 Adult Brain    122.4 Adult Thoracic-Abdominal Ganglion    79.3 Adult Crop    47.9 Adult Midgut    37.7 Adult Hindgut    50.8 Adult Malpighian Tubules    26.7 Adult Fat Body    23.9 Adult Salivary Gland    61.8 Adult Heart    24.85 Adult VirginFemale Spermatheca    26.4 Adult InseminatedFemale Spermatheca    27.4 Adult Ovary    149.1 Adult Testis    40.4 Adult Male Accessory Gland    41.7 Adult Carcass    30.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0003330 expression level Tissue   Expression Level Larval Central Nervous System    169.15 Larval Midgut    30.7 Larval Hindgut    63.1 Larval Malpighian Tubules    39.4 Larval Fat Body    37.7 Larval Salivary Gland    73.5 Larval Trachea    60.3 Larval Carcass    43.925 Adult Head    55.4 Adult Eye    57.975 Adult Brain    122.4 Adult Thoracic-Abdominal Ganglion    79.3 Adult Crop    47.9 Adult Midgut    37.7 Adult Hindgut    50.8 Adult Malpighian Tubules    26.7 Adult Fat Body    23.9 Adult Salivary Gland    61.8 Adult Heart    24.85 Adult VirginFemale Spermatheca    26.4 Adult InseminatedFemale Spermatheca    27.4 Adult Ovary    149.1 Adult Testis    40.4 Adult Male Accessory Gland    41.7 Adult Carcass    30.4 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    169.15 Larval Midgut    30.7 Larval Hindgut    63.1 Larval Malpighian Tubules    39.4 Larval Fat Body    37.7 Larval Salivary Gland    73.5 Larval Trachea    60.3 Larval Carcass    43.925 Adult Head    55.4 Adult Eye    57.975 Adult Brain    122.4 Adult Thoracic-Abdominal Ganglion    79.3 Adult Crop    47.9 Adult Midgut    37.7 Adult Hindgut    50.8 Adult Malpighian Tubules    26.7 Adult Fat Body    23.9 Adult Salivary Gland    61.8 Adult Heart    24.85 Adult VirginFemale Spermatheca    26.4 Adult InseminatedFemale Spermatheca    27.4 Adult Ovary    149.1 Adult Testis    40.4 Adult Male Accessory Gland    41.7 Adult Carcass    30.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    169.15 Larval Midgut    30.7 Larval Hindgut    63.1 Larval Malpighian Tubules    39.4 Larval Fat Body    37.7 Larval Salivary Gland    73.5 Larval Trachea    60.3 Larval Carcass    43.925 Adult Head    55.4 Adult Eye    57.975 Adult Brain    122.4 Adult Thoracic-Abdominal Ganglion    79.3 Adult Crop    47.9 Adult Midgut    37.7 Adult Hindgut    50.8 Adult Malpighian Tubules    26.7 Adult Fat Body    23.9 Adult Salivary Gland    61.8 Adult Heart    24.85 Adult VirginFemale Spermatheca    26.4 Adult InseminatedFemale Spermatheca    27.4 Adult Ovary    149.1 Adult Testis    40.4 Adult Male Accessory Gland    41.7 Adult Carcass    30.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    169.15 Larval Midgut    30.7 Larval Hindgut    63.1 Larval Malpighian Tubules    39.4 Larval Fat Body    37.7 Larval Salivary Gland    73.5 Larval Trachea    60.3 Larval Carcass    43.925 Adult Head    55.4 Adult Eye    57.975 Adult Brain    122.4 Adult Thoracic-Abdominal Ganglion    79.3 Adult Crop    47.9 Adult Midgut    37.7 Adult Hindgut    50.8 Adult Malpighian Tubules    26.7 Adult Fat Body    23.9 Adult Salivary Gland    61.8 Adult Heart    24.85 Adult VirginFemale Spermatheca    26.4 Adult InseminatedFemale Spermatheca    27.4 Adult Ovary    149.1 Adult Testis    40.4 Adult Male Accessory Gland    41.7 Adult Carcass    30.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    55.4   NA  Eye    57.975   NA  Brain    122.4   169.15  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    79.3   NA  Crop    47.9   30.7  Midgut    37.7   63.1  Hindgut    50.8   39.4  Malpighian Tubules    26.7   37.7  Fat Body    23.9   73.5  Salivary Gland    61.8   NA  Heart    24.85   60.3  Trachea    NA   NA  VirginFemale Spermatheca    26.4   NA  InseminatedFemale Spermatheca    27.4   NA  Ovary    149.1   NA  Testis    40.4   NA  Male Accessory Gland    41.7   43.925  Carcass    30.4 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003330 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5595-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Sce Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal (with Df(3R)IR16) Sce1 lethal | embryonic stage Sce1 lethal | larval stage SceD1 lethal | larval stage | recessive Sce1 lethal | pupal stage, with Scer\GAL4en.PU SceY307A.Scer\UAS.T:Zzzz\FLAG lethal | recessive SceD1 semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 SceGD11702 Other Phenotypes Allele decreased cell number | somatic clone Sce1 mitotic cell cycle defective | somatic clone Sce1 suppressor of variegation | dominant, with P{hsp26-pt-T}39C-5 Sce1 suppressor of variegation | dominant, with P{hsp26-pt-T}39C-27 Sce1 suppressor of variegation | dominant, with P{hsp26-pt-T}39C-31 Sce1 suppressor of variegation | dominant, with P{SUPor-P.PRE#2}9M2 SceD1 suppressor of variegation | dominant, with P{SUPor-P.PRE#6}4 SceD1 suppressor of variegation | dominant, with P{SUPor-P.PRE#6}69M3 SceD1 suppressor of variegation | dominant, with P{wA}4-4 Sce1 visible, with Scer\GAL4pnr-MD237 SceGD11702 visible | somatic clone Sce33M2 Phenotype manifest in Allele abdominal 4 ventral denticle belt Sce1 adult thorax, with Scer\GAL4en.PU SceY307A.Scer\UAS.T:Zzzz\FLAG denticle belt Sce1 denticle belt | germline clone Sce1 egg chamber | somatic clone Sce1 embryonic/larval tracheal system | germline clone Sce1 embryonic abdominal segment Sce1 embryonic abdominal segment 8 | ectopic Sce1 embryonic abdominal segment 8 | ectopic | rescuable maternal effect Sce1 embryonic abdominal segment | rescuable maternal effect Sce1 embryonic head | rescuable maternal effect Sce1 embryonic thoracic segment Sce1 Sce33M2 Fell hairs | ectopic Sce1 germarium region 3 | somatic clone Sce1 interfollicle cell | cell non-autonomous | ectopic | somatic clone Sce1 Keilin's organ | germline clone Sce1 Kolbchen | germline clone Sce1 larval abdominal segment 1 | germline clone Sce1 larval abdominal segment 2 | germline clone Sce1 larval abdominal segment 3 | germline clone Sce1 larval abdominal segment 4 | germline clone Sce1 larval abdominal segment 5 | germline clone Sce1 larval abdominal segment 6 | germline clone Sce1 larval abdominal segment 7 Sce1 larval abdominal segment 7 | germline clone Sce1 larval mesothoracic segment | germline clone Sce1 larval metathoracic segment | germline clone Sce1 larval prothoracic segment | germline clone Sce1 mesothoracic tergum, with Scer\GAL4pnr-MD237 SceGD11702 mesothoracic ventral denticle belt Sce33M2 metathoracic ventral denticle belt Sce33M2 neuroblast | somatic clone Sce1 prothoracic ventral denticle belt Sce33M2 stage 14 embryo | rescuable maternal effect Sce1 wing | somatic clone Sce33M2
Classical Alleles ( 4 )
For All Classical Alleles Show
Allele of Sce Class Mutagen Stocks Known lesion Sce1 amorphic allele - genetic evidence ethyl nitrosourea 2 Yes Sce33M2 ethyl methanesulfonate 0 Yes Sceb1 0 -- SceD1 0 --
Alleles Carried on Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Sce Class Mutagen Stocks Known lesion SceGD11702 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes SceGL00371 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes SceJF01396 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes SceKK109179 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ScedsRNA.cWa in vitro construct - RNAi 0 Yes SceScer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes SceScer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion 0 Yes SceY307A.Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)IR16 (Gorfinkiel et al., 2004)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct M{UAS-Sce.Y307A-FLAG} NA M{UAS-Sce-FLAG.WT} NA P{GD11702} NA P{KK109179} NA P{TRiP.GL00371} NA P{TRiP.JF01396} NA P{UAS-Sce.Myc} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 13 unique terms )
Terms Based on Experimental Evidence ( 11 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with ord (assigned by UniProtKB) (Balicky et al., 2004)
Biological Process
CV term Evidence References
chromatin silencing inferred from direct assay (assigned by UniProtKB) (Fritsch et al., 2003) germarium-derived female germ-line cyst encapsulation inferred from mutant phenotype (Narbonne et al., 2004) multicellular organismal development inferred from direct assay (assigned by UniProtKB) (Simon et al., 1992) neurogenesis inferred from mutant phenotype (Bello et al., 2007) ovarian follicle cell stalk formation inferred from mutant phenotype (Narbonne et al., 2004) sex comb development inferred from direct assay (assigned by UniProtKB) (Simon et al., 1992) sister chromatid cohesion inferred from mutant phenotype (assigned by UniProtKB) (Balicky et al., 2004)
Cellular Component
CV term Evidence References
cohesin complex inferred from direct assay (assigned by UniProtKB) (Balicky et al., 2004) nucleolus inferred from direct assay (Chen et al., 2005) nucleus inferred from direct assay (Mulholland et al., 2003)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
zinc ion binding inferred from electronic annotation with InterPro:IPR001841 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
PRC1 complex traceable author statement (Levine et al., 2004)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Sce allele Gene References Sce1 E(z) (Bajusz et al., 2001) gpp (Shanower et al., 2005) Psc (Sharp et al., 1994) Su(z)2 (Sharp et al., 1994) w (Netter et al., 1998, Muller et al., 1999, Bloyer et al., 2003) SceD1 ash1 (Gildea et al., 2000) brm (Gildea et al., 2000) Scm (Bornemann et al., 1998) trx (Gildea et al., 2000) unspecified Abd-B (Muller et al., 1999) ara (Netter et al., 1998) Asx (Campbell et al., 1995) E(Pc) (Campbell et al., 1995) E(z) (Campbell et al., 1995) Pc (Campbell et al., 1995) Pcl (Campbell et al., 1995) pho (Campbell et al., 1995) ph-p (Fauvarque et al., 1995) ph-PRE (Bloyer et al., 2003) Psc (Campbell et al., 1995) Scm (Campbell et al., 1995) sxc (Campbell et al., 1995)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68209 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0003330 DroID - A comprehensive database of gene and protein interactions. • FBgn0003330 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43327
Orthologs
Genome-wide drosophilid orthologs	Dana\GF18697 Dere\GG12099 Dgri\GH17005 Dmoj\GI10743 Dper\GL13768 Dpse\GA18995 Dsec\GM16329 Dsim\GD18065 Dvir\GJ10686 Dwil\GK11322 Dyak\GE10548
Curated drosophilid orthologs	Dpse\GA18995
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL012209-PA Aedes aegypti (mosquito) AGAP002073-PA Anopheles gambiae (mosquito) XP_393984.2 Apis mellifera (honey bee) XP_001942602.1 Acyrthosiphon pisum (pea aphid) At1g03770.1 Arabidopsis thaliana (wall cress) At5g44280.1 Arabidopsis thaliana (wall cress) 122927 Branchiostoma floridae (lancelet) BGIBMGA006985-PA Bombyx mori (silk worm) ENSBTAP00000000025 Bos taurus (bovine) CAL0003934 Candida albicans (a form of yeast) ENSCAFP00000019876 Canis familiaris (dog) ENSCINP00000019449 Ciona intestinalis (sea squirt) CPIJ009418 Culex pipens (mosquito) ENSCPOP00000012564 Cavia porcellus (guinea pig) RP42110 Caenorhabditis remanei (nematode) ENSCSAVP00000015925 Ciona savignyi (sedentary tunicate) 219532 Capitella spl (polychaete worm) 202413 Daphnia pulex (daphnia) ENSDARP00000002609 Danio rerio (zebra fish) ENSECAP00000012533 Equus caballus (horse) ENSGACP00000019278 Gymnopilus aculeatus (mushroom) ENSGALP00000007694 Gallus gallus (chicken) ENSP00000363787 Homo sapiens (human) ENSP00000372557 Homo sapiens (human) ENSP00000372699 Homo sapiens (human) ISCW016231-PA Ixodes scapularis (deer tick) ENSMODP00000017718 Monodelphis domestica (gray opossum) ENSMMUP00000005154 Macaca mulatta (rhesus monkey) ENSMUSP00000075476 Mus musculus (house mouse) XP_001608228.1 Nasonia vitripennis (wasp) ENSOANP00000001603 Ornithorynchus anatinus (platypus) ENSORLP00000006752 Oryzias latipes (japanese killifish) LOC_Os03g58390.1 Oryza sativa (asian rice) PHUM002051-PA Pediculus humanus (human body louse) PP15581 Pristionchus pacificus (nematode) 173127 Physcomitrella patens (moss) ENSPPYP00000019327 Pongo pygmaeus (orangutan) 83899 Phytophthora ramorum (sudden oak death pathogen) 137036 Phytophthora sojae (root rot pathogen) 594655 Populus trichocarpa (black cottonwood) ENSPTRP00000030805 Pan troglodytes (chimpanzee) ENSRNOP00000003471 Rattus norvegicus (norway rat) 5059764 Sorghum bicolor (sorghum) Smp_050160 Schistosoma mansoni (trematode parasite) XP_970564.1 Tribolium castaneum (red flour beetle) ENSTNIP00000021314 Tetraodon nigroviridis (green spotted pufferfish) ENSXETP00000055088 Xenopus tropicalis (frog) YALI0B00110g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV14190 LH23892 ISCW016231 FBgn0228405 FBgn0213333 FBgn0197964 FBgn0189609 FBgn0171245 JGI_V11_202413 FBgn0078994 FBgn0151373 FBgn0133507 FBgn0124476 FBgn0104391 FBgn0095715 CPIJ009418 BGIBMGA006985 ACYPI009684 ACYPI007206 ACYPI006307 ACYPI004477 ACYPI004367 ACYPI003259 GB13204 AGAP002073 AAEL012209 PB22380 PHUM464900 GLEAN_01392
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	31612 y1 v1; P{TRiP.JF01396}attP2 7364 pp Abd-BMcp-1 Sce1/TM1 35446 y1 sc* v1; P{TRiP.GL00371}attP2/TM3, Sb1 24618 w*; P{neoFRT}82B Abd-BMcp-1 Sce1/TM6C, Sb1 Tb1
VDRC	v106328 P{KK109179}VIE-260B v27465 w1118; P{GD11702}v27465
Genomic Clones ( 1 )
	BACR02M05 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 64 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD23953
Other clones	DPiM_LD23953
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD03177 LD06636 LD09046 LD11273 LD19196 LD19556 LD25958 LD27028 LD35974 LD38948 LD41628 LD42158 LD43929 LP23558 RE15121 RE24756 RE28263 RE40464 RE47418 RE50965 RE73112 RE73781 RE74093 RH22414 RH24123 RH26819 RH66138
Other clones	81226 165910 214349.17 CK01.54A.C5 Dmel_dig_013703_0679_0451 EK044011 EK214132 EK270442 RE01706 RP003034261 RP003040037 RP003046221 RP003066037 RP003109679 RP003159801 RP003171686 RP003214619 RP003283434 RP003331455 RP003360869 RP003387665 RP003425184 RP003436136 RP003484407 RP003492789 RP003495131 RP003503699 RP003507633 RP003521525 RP003539005 RP003546941 RP003554785 RP003555053 RP003647084 RP003673371
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0003330 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43327
Antibody Information
	polyclonal (Gorfinkiel et al., 2004)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Sce Ring (Fritsch et al., 2003)
Additional comments
Other Comments
	DNA-protein interactions: genome-wide binding profile assayed for Sce protein in Kc167 cells; see Chromatin_types_NKI collection report. Individual protein-binding experiments listed under "Samples" at GEO_GSE22069 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE22069). (Filion et al., 2010) Gene expression is increased in response to the presence of two copies of Scer\GAL4hs.PB. (Liu and Lehmann, 2008) Sce is required for normal neuroblast survival and proliferation in postembryonic central nervous system development. (Bello et al., 2007) Silencing activity of the iab-7PRE in the bithorax complex is dependent upon proteins from the Polycomb group. (Hagstrom et al., 1997) In an effort to subdivide the Pc-group genes functionally, the phenotypes of adult flies heterozygous for every pairwise combination of Pc-group mutation were examined. Asx, Pc, Pcl, Psc, Scm and Sce have similar functions in some imaginal tissues. Most duplications of Pc-group genes neither exhibit anterior transformations nor suppress the extra sex comb phenotype of Pc-group mutations, suggesting that not all Pc-group genes behave as predicted by the mass action model. (Campbell et al., 1995) Sections of the Scr regulatory region may be important for regulation of Scr by Polycomb- and trithorax-group genes. (Gindhart and Kaufman, 1995) Mutations of genes in the polycomb group (esc, E(z), Pc, ph-p, ph-d, Scm, Pcl, Sce, Asx, Psc, pho and Antp) cause abnormal segmental development due to the ectopic expression of abd-A and Abd-B. Embryos lacking both maternal and zygotic Sce product were generated to determine abd-A and Abd-B expression patterns. (Simon et al., 1992) The Pc group genes are negative regulators of homeotic genes. (McKeon and Brock, 1991) Pole cell transplantation techniques demonstrate that Sce is maternally expressed and is required for normal BXC expression during embryogenesis. (Breen and Duncan, 1986)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_058161 RefSeq (Proteins) • NP_477509 DDBJ / EMBL / GenBank • AA263407 AA820372 AAF56737 AAL13764 AC007818 AI455406 AJ001514 AY058535 CAA04797 Entrez Gene - A searchable database of RefSeq genes. • 43327 UniProtKB/Swiss-Prot • Q9VB08
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, RING-type (IPR001841) Zinc finger, C3HC4 RING-type (IPR018957) Zinc finger, RING-type, conserved site (IPR017907) Zinc finger, RING/FYVE/PHD-type (IPR013083)
Linkouts
	BioGRID - A database of protein and genetic interactions • 68209 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0003330 DroID - A comprehensive database of gene and protein interactions. • FBgn0003330 DRSC - Results from RNAi screens. • FBgn0003330 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003330 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5595-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0003330 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43327 InParanoid A subset of ortholog calls from InParanoid. • AAEL012209-PA Aedes aegypti (mosquito) AGAP002073-PA Anopheles gambiae (mosquito) XP_393984.2 Apis mellifera (honey bee) XP_001942602.1 Acyrthosiphon pisum (pea aphid) At1g03770.1 Arabidopsis thaliana (wall cress) At5g44280.1 Arabidopsis thaliana (wall cress) 122927 Branchiostoma floridae (lancelet) BGIBMGA006985-PA Bombyx mori (silk worm) ENSBTAP00000000025 Bos taurus (bovine) CAL0003934 Candida albicans (a form of yeast) ENSCAFP00000019876 Canis familiaris (dog) ENSCINP00000019449 Ciona intestinalis (sea squirt) CPIJ009418 Culex pipens (mosquito) ENSCPOP00000012564 Cavia porcellus (guinea pig) RP42110 Caenorhabditis remanei (nematode) ENSCSAVP00000015925 Ciona savignyi (sedentary tunicate) 219532 Capitella spl (polychaete worm) 202413 Daphnia pulex (daphnia) ENSDARP00000002609 Danio rerio (zebra fish) ENSECAP00000012533 Equus caballus (horse) ENSGACP00000019278 Gymnopilus aculeatus (mushroom) ENSGALP00000007694 Gallus gallus (chicken) ENSP00000363787 Homo sapiens (human) ENSP00000372557 Homo sapiens (human) ENSP00000372699 Homo sapiens (human) ISCW016231-PA Ixodes scapularis (deer tick) ENSMODP00000017718 Monodelphis domestica (gray opossum) ENSMMUP00000005154 Macaca mulatta (rhesus monkey) ENSMUSP00000075476 Mus musculus (house mouse) XP_001608228.1 Nasonia vitripennis (wasp) ENSOANP00000001603 Ornithorynchus anatinus (platypus) ENSORLP00000006752 Oryzias latipes (japanese killifish) LOC_Os03g58390.1 Oryza sativa (asian rice) PHUM002051-PA Pediculus humanus (human body louse) PP15581 Pristionchus pacificus (nematode) 173127 Physcomitrella patens (moss) ENSPPYP00000019327 Pongo pygmaeus (orangutan) 83899 Phytophthora ramorum (sudden oak death pathogen) 137036 Phytophthora sojae (root rot pathogen) 594655 Populus trichocarpa (black cottonwood) ENSPTRP00000030805 Pan troglodytes (chimpanzee) ENSRNOP00000003471 Rattus norvegicus (norway rat) 5059764 Sorghum bicolor (sorghum) Smp_050160 Schistosoma mansoni (trematode parasite) XP_970564.1 Tribolium castaneum (red flour beetle) ENSTNIP00000021314 Tetraodon nigroviridis (green spotted pufferfish) ENSXETP00000055088 Xenopus tropicalis (frog) YALI0B00110g Yarrowia lipolytica (nonconventional yeast) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /polycomb/sexcombex-ring1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43327 modMine - Data generated by the modENCODE project. • FBgn0003330 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV14190 LH23892 ISCW016231 FBgn0228405 FBgn0213333 FBgn0197964 FBgn0189609 FBgn0171245 JGI_V11_202413 FBgn0078994 FBgn0151373 FBgn0133507 FBgn0124476 FBgn0104391 FBgn0095715 CPIJ009418 BGIBMGA006985 ACYPI009684 ACYPI007206 ACYPI006307 ACYPI004477 ACYPI004367 ACYPI003259 GB13204 AGAP002073 AAEL012209 PB22380 PHUM464900 GLEAN_01392
Synonyms & Secondary IDs ( 18 )
Reported As
Symbol Synonym	CG5595 (Keleman et al., 2009.8.5, Ni et al., 2008, Ni et al., 2011.7.19) Ding   dRing (Lund and van Lohuizen, 2004, Wang et al., 2004, Chen et al., 2006, Schuettengruber, 2006, Chen et al., 2005) dRING (Balicky et al., 2001, van Lohuizen, 1999, Buszczak and Spradling, 2006, Zhou and Bickel, 2008, Francis et al., 2009, Lee et al., 2010) DRING (Dyer, 1997.9.9) Dring   dring (Balicky et al., 2004, Tuckfield et al., 2002) dRING1 (Marx, 2005, Lavigne et al., 2004, Peterson et al., 2004, Mulholland et al., 2003, Francis et al., 2001, Simon and Tamkun, 2002, Mallin et al., 2002, Saurin et al., 2001, King et al., 2002, Lo et al., 2009, Mohd-Sarip et al., 2006, Wang et al., 2010) dRing1 (King et al., 2005) Ring (Brookman, 1998.5.13, Giot et al., 2003, Khan et al., 2009) RING (Schwartz and Pirrotta, 2007, Oktaba et al., 2008) RING1 (Simon, 2003, Ali and Bender, 2004) Ring/Sce (Papp and Muller, 2006) Rnf2   Sce (Brown et al., 2005, Adler et al., 1991, Gan et al., 2010, Bello et al., 2007, Muller and Kassis, 2006, Zhou and Bickel, 2008, Bejarano et al., 2005, Liu and Lehmann, 2008, de Ayala Alonso et al., 2007, Blastyak et al., 2006, Pindyurin et al., 2007, González et al., 2008, Oktaba et al., 2008, Shevelyov et al., 2009, Tolhuis et al., 2006, Classen et al., 2009, de Wit et al., 2008, Li et al., 2010, Scheuermann et al., 2010, Wang et al., 2010) SCE (Schwartz and Pirrotta, 2007, van Steensel et al., 2010, Filion et al., 2010)
Name Synonym	dRing1 (Levine et al., 2004) dRING1 (Maeda and Karch, 2006) Ring (Muller and Kassis, 2006, Gambetta et al., 2009, Gambetta et al., 2009) Sex comb extra (Bejarano et al., 2005) Sex combs extra (Brown et al., 2005, Maeda and Karch, 2006, Bello et al., 2007, Muller and Kassis, 2006, Zhou and Bickel, 2008, Ali and Bender, 2004, Blastyak et al., 2006, Classen et al., 2009)
Secondary FlyBase IDs
	FBgn0020911
References ( 112 )
Generate a list of	All references relating to this gene ( 112 )
List References by type	Research paper  ( 75 ) Supplementary material  ( 5 ) Review  ( 14 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 6 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 1 ) Book  ( 1 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 7 )
	Filion et al., 2010, Cell 143(2): 212--224 Systematic protein location mapping reveals five principal chromatin types in Drosophila cells. [FBrf0212051] Gan et al., 2010, Cell Res. 20(7): 763--783 Dynamic regulation of alternative splicing and chromatin structure in Drosophila gonads revealed by RNA-seq. [FBrf0211191] Lee et al., 2010, Mol. Cell. Biol. 30(10): 2563--2577 Drosophila RB proteins repress differentiation-specific genes via two different mechanisms. [FBrf0210656] Li et al., 2010, Genes Dev. 24(9): 933--946 Polycomb group genes Psc and Su(z)2 restrict follicle stem cell self-renewal and extrusion by controlling canonical and noncanonical Wnt signaling. [FBrf0210675] Scheuermann et al., 2010, Nature 465(7295): 243--247 Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB. [FBrf0210760] van Steensel et al., 2010, Genome Res. 20(2): 190--200 Bayesian network analysis of targeting interactions in chromatin. [FBrf0209848] Wang et al., 2010, Structure 18(8): 966--975 Polycomb Group Targeting through Different Binding Partners of RING1B C-Terminal Domain. [FBrf0211462] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...