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Gene Dmel\sd

General Information
Symbol	Dmel\sd	Species	D. melanogaster
Name	scalloped	Annotation symbol	CG8544
Feature type	protein_coding_gene	FlyBase ID	FBgn0003345
Gene Model Status	Current	Stock availability	74 publicly available
Genomic Location
Chromosome (arm)	X	Recombination map	1-51.5
Cytogenetic map	13F1-13F4	Sequence location	X:15,698,403..15,721,714 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene scalloped is referred to in FlyBase by the symbol Dmel\sd (CG8544, FBgn0003345). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: RNA polymerase II distal enhancer sequence-specific DNA binding; transcription factor binding; transcription regulatory region DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; protein domain specific binding. There is experimental evidence that it is involved in the biological process: wing disc development; somatic muscle development; positive regulation of transcription from RNA polymerase II promoter; sensory organ development; stem cell proliferation; imaginal disc-derived wing morphogenesis; imaginal disc-derived leg morphogenesis; cardiac muscle cell development; compound eye morphogenesis. 203 alleles are reported. The phenotypes of these alleles are annotated with: adult segment; organ system subdivision; organ system; thoracic segment; ISN innervated muscle of A1-7; hypodermal muscle of larval abdomen; external compound sense organ; imaginal precursor; non-connected developing system; indirect flight muscle. It has 20 annotated transcripts and 20 annotated polypeptides. Protein features are: TEA/ATTS; Transcriptional enhancer factor. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 06-18 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval trachea. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult salivary gland, adult spermathecae, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1625515_a_at completely aligns to an exonic region common to each of the 9 FlyBase-annotated transcript isoforms of sd. Gene sequence location is X:15698403..15721714.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	sd: scalloped (S. D. Campbell and A. Chovnick) sd: scalloped From Edith M. Wallace, unpublished. Wing margins scalloped and veins thickened. Eyes slightly roughened. Does not overlap wild type. Additional defects noted are uplifting of posterior scutellar bristles, haltere diminution, and ectopic bristles on the wing blade. RK1. *sd2 More extreme than sd. Wings small and scalloped. Like vg at high temperatures. Crossing over inhibited. RK2A? *sd56j More extreme than sd. Expression enhanced by high temperature. Visible in prepupal wing buds. Interacts with Bx and bi. RK1. sd58d Wings reduced to vestiges, like vg. Halteres and bristles also like vg. sd58d/sd has strap-shaped wing. Temperature sensitive; effects of temperature pulses at different developmental stages suggest that wing areas eliminated in a specific order (Simpson, Lawrence, and Maschat, 1981, Dev. Biol. 84: 206-11). RK2A. sd[ry+] Extreme allele of sd associated with the insertion of a P element carrying ry+ at 13F. In hemizygous males, wings reduced to mere vestiges similar to vg; in homozygous females the wings are narrow and strap-like. One or both scutellar bristles are sometimes truncated, and halteres appear somewhat reduced in males. Severity of wing defect may vary with temperature. Under dysgenic conditions, excision of the P element leads to the loss of ry+ and amelioration of the sd phenotype (i.e., wild type or nibbled wings); the molecular lesions of a number of such derivatives have been characterized (Daniels, McCarron, Love, and Chovnick, 1985, Genetics 109: 95-117). One derivative was used as a "tag" for cloning the sd region (Campbell et al.). *sds: scalloped-sterile Wings divergent and slightly nicked. Male sterile. RK2. sdsp: scalloped-spatula Wings cut at tips and along both margins. sdsp +/+ Bxr give slight nicking of wings. RK1A. sdts Wings vestigial-like at 29; also capitellum of haltere extremely reduced; some crippling of legs. At 22 wings have parts of wing blade or wing margin or both missing; halteres normal. Viability and fertility good at 22. Increases incidence of pattern duplications and deficiencies in l(1)ts504. *sdUCI Extreme vestigial-like wing (as in sd58d) with erect postscutellar bristles. Halteres greatly reduced in size. In some flies, outgrowths of tissue found on one side of the metanotum; in extreme cases, these outgrowths can be recognized as mirror-image pattern duplications of the notum and ventral hinge and reduction of the wing blade. Pupation delayed until about 168 hr after oviposition, with four days being spent as third-instar larvae. Average size of mature wing disk about 56% normal; reduction in size and pattern duplication attributable to extensive cell death in the wing imaginal disk. Wing margins of sdUCI/Basc females frequently incised; such females also produce significant numbers of patroclinous males. (Vyse and James, 1972, DIS 49: 39; James and Bryant, 1981, Dev. Biol. 85: 39-54).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02	Controlled Vocabulary Terms hippo signaling cascade
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 13F1-13F4   Limits computationally determined from genome sequence between P{EP}BEST:RE35685EP1581&P{EP}sdEP1088 and P{EP}Gβ13FEP1071
Experimentally Determined Cytological Location
Cytogenetic map Notes References 13F1-13F4   (determined by in situ hybridisation) 13E13--F2 (determined by in situ hybridisation) 13F1--2 (determined by in situ hybridisation)   (Peter et al., 2002) 13F1-13F2   (determined by in situ hybridisation)   (Abdelilah-Seyfried et al., 2000) 13F-13F   (determined by in situ hybridisation)   (Shyamala and Chopra, 1999) 13F1-13F2   (determined by in situ hybridisation)   (Schaefer et al., 1999.12.2) 13F1-13F2   (determined by in situ hybridisation) 13E13--F2 (determined by in situ hybridisation)   (Schaefer et al., 1999.6.15) 13E-13F   (determined by in situ hybridisation)   (Inamdar et al., 1993) 13F-13F   (determined by in situ hybridisation)   (Campbell et al., 1992) 13F-13F   (determined by in situ hybridisation)   (Campbell et al., 1991)
Experimentally Determined Recombination Data
Location	1-51.5
Left of (cM)	nonA (Kulkarni et al., 1988) B (Valencia, 1959) vb (Waddle et al., 1991)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\sd for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.43 Gene model reviewed during 5.50 Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters. Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) sd-RA FBtr0074100  NM_167465   2677   370 sd-RB FBtr0074099  NM_078614   3194   440 sd-RC FBtr0074101  NM_206727   2835   370 sd-RD FBtr0112824  NM_001103519   3288   410 sd-RE FBtr0112825  NM_001103520   3252   440 sd-RF FBtr0112826  NM_001103521   3047   440 sd-RG FBtr0112827  NM_001103522   3139   440 sd-RH FBtr0301543  NM_001169290   3237   435 sd-RI FBtr0301544  NM_001169291   3280   435 sd-RJ FBtr0308128  NM_001258767   3942   410 sd-RK FBtr0308129  NM_001258768   3113   440 sd-RL FBtr0308130  NM_001258769   2621   370 sd-RM FBtr0308131  NM_001258770   5331   435 sd-RN FBtr0308132  NM_001258771   3471   370 sd-RO FBtr0308133  NM_001258772   3678   410 sd-RP FBtr0308134  NM_001258773   3355   410 sd-RQ FBtr0310311  NM_001272652   3670   625 sd-RR FBtr0310312  NM_001272653   3076   440 sd-RS FBtr0310313  NM_001272654   3164   440 sd-RT FBtr0340115     2666   375
Additional Transcript Data & Comments
Reported size (kB)	4.5, 3.3 (northern blot) (Campbell et al., 1991)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein sd-PA   FBpp0073915   42.5   370   7.09     NP_727900   AAN09366 sd-PB   FBpp0073914   49.7   440   6.03     NP_511169   AAF48521 sd-PC   FBpp0089157   42.5   370   7.09     NP_996450   AAS65351 sd-PD   FBpp0111736   46.5   410   6.78     NP_001096989   ABW09420 sd-PE   FBpp0111737   49.7   440   6.03     NP_001096990   ABW09421 sd-PF   FBpp0111738   49.7   440   6.03     NP_001096991   ABW09422 sd-PG   FBpp0111739   49.7   440   6.03     NP_001096992   ABW09423 sd-PH   FBpp0290758   49.0   435   6.28     NP_001162761   ACZ95296 sd-PI   FBpp0290759   49.0   435   6.28     NP_001162762   ACZ95297 sd-PJ   FBpp0300450   46.5   410   6.78     NP_001245696   AFH07409 sd-PK   FBpp0300451   49.7   440   6.03     NP_001245697   AFH07410 sd-PL   FBpp0300452   42.5   370   7.09     NP_001245698   AFH07411 sd-PM   FBpp0300453   49.0   435   6.28     NP_001245699   AFH07412 sd-PN   FBpp0300454   42.5   370   7.09     NP_001245700   AFH07413 sd-PO   FBpp0300455   46.5   410   6.78     NP_001245701   AFH07414 sd-PP   FBpp0300456   46.5   410   6.78     NP_001245702   AFH07415 sd-PQ   FBpp0301994   69.1   625   7.61     NP_001259581   AGB95423 sd-PR   FBpp0301995   49.7   440   6.03     NP_001259582   AGB95424 sd-PS   FBpp0301996   49.7   440   6.03     NP_001259583   AGB95425 sd-PT   FBpp0309110   43.1   375   6.78
Additional Polypeptide Data & Comments
Reported size (kDa)	440 (aa) (Campbell et al., 1992)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • TEA/ATTS (IPR000818) Transcriptional enhancer factor (IPR016361)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA696994   AA816604   AE014298 AAF48521   AE014298 AAN09366   AE014298 AAS65351   AE014298 ABW09420   AE014298 ABW09421   AE014298 ABW09422   AE014298 ABW09423   AE014298 ACZ95296   AE014298 ACZ95297   AE014298 AFH07409   AE014298 AFH07410   AE014298 AFH07411   AE014298 AFH07412   AE014298 AFH07413   AE014298 AFH07414   AE014298 AFH07415   AE014298 AGB95423   AE014298 AGB95424   AE014298 AGB95425   AI124301   AI541910   AI542068   AJ426940   AJ426941   AJ426943   AJ426945   AQ025381   AQ025462   AY071181 AAL48803   AY863462   AY863463   AY863464   AY863465   AY863466   AY863467   AY863468   AY863469   AY863470   AY863471   AY863472   AY863473   AY863474   AY863475   AY863476   AY863477   AY863478   AY863479   AY863480   AY863481   BF494317   BG637192   BG639901   BI216193   BI231690   BI239249   BI486630   BI619092   BP555443   BT023934   BT029128   BT126285   BT133072   CO152680   CO152715   CO156112   CO272073   CO272499   CO272604   CO273209   CO280922   CO285665   CO294414   CO298916   CO303731   CO304284   CO305674   CO306360   CO307938   CO308709   CO310222   CO313259   CO314033   CO317211   CO317840   CO321009   CO321072   CO325151   CO329192   CO330320   CO330418   CO342577   CZ473820   CZ476708   CZ480145   CZ486626   CZ487021   CZ488730   CZ488731   CZ489177   CZ489178   DN154091   DQ327770   EC060954   EC062201   EC071677   EC074216   EC076029   EC076570   EC077469   EC078072   EC078163   EC079094   EC084072   EC204933   EC204941   EC206623   EC209703   EC210061   EC212258   EC215083   EC222306   EC226325   EC227742   EC232108   EC232430   EC236829   EC237288   EC237833   EC238142   EC239591   EC247910   EC249992   EC262095   EC263559   EC265375   EL885118   EL885119   EV575522   EV597865   GH861341   GH961999   GH964556   GH965942   GH966569   GH966885   GH973264   GH982593   L07659   L07660   L07661   L07662   L07663   M83787 AAA28881   Z32346
UniProtKB/Swiss-Prot	P30052
UniProtKB/TrEMBL	Q8IR25 A8JUY9 A8JUY5 E1JJ99 Q8SZ20
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage   sense organ   (Campbell et al., 1992) embryonic stage 9 -- 17   central nervous system   (Campbell et al., 1992) larval stage   scutellum | precursor   (Campbell et al., 1992) antennal sense organ   (Campbell et al., 1992) embryonic/larval labral segment sense organ   (Campbell et al., 1992) wing disc   (Campbell et al., 1992) adult stage   protocerebrum   (Campbell et al., 1992) mesothoracic extracoxal depressor muscle 66   (Campbell et al., 1992) photoreceptor cell   (Campbell et al., 1992) mushroom body calyx   (Campbell et al., 1992) in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   supraesophageal ganglion   (Campbell et al., 1992) perineurial sheath glial cell   (Campbell et al., 1992) embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   antennal primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium central brain primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium visual primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium dorsal head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium lateral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium ventral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium organism | ubiquitous   (Fisher et al., 2012) ventral ectoderm   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 11   organism   (Bantignies et al., 2003) embryonic stage 11 -- 12   central brain primordium   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 11 -- 17   peripheral nervous system   (Campbell et al., 1992) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012) larval stage   maxillary palp sense organ   (Campbell et al., 1992) eye-antennal disc   (Campbell et al., 1992) anepisternum | precursor   (Campbell et al., 1992)   (Campbell et al., 1992) third instar larval stage   wing pouch   (Bantignies et al., 2003) adult stage   sacculus   (Campbell et al., 1992) subesophageal ganglion | restricted   (Campbell et al., 1992) subesophageal ganglion   (Campbell et al., 1992) microchaeta   (Campbell et al., 1992)
Additional Descriptive Data
	sd expression is first observed in embryos at stage 9 in cephalic neuroblasts. Expression continues weakly in the CNS throughout embryogenesis and includes sheath cells. Expression in the PNS is first observed at stage 11. By stage 14, intense staining is seen in ventral and lateral sense organs along the trunk and in the antennomaxillary complex. During head involution, strong expression is observed in the antennomaxillary complex and in the labral sense organs. In larvae, expression is observed in a restricted set of cells in the optic proliferation centers, the cerebral hemispheres and the ventral ganglion. The cells are probably not neuroblasts and may be glia or sheath cells. sd expression is observed in all of the imaginal discs except the labial disc. Expression in the wing disc occurs in regions that will give rise to the adult wing blade, the scutellum, and the mesopleura. In the eye disc, expression initiates immediately behind the morphogenetic furrow. In adults, sd expression is observed in discrete regions of the adult brain including cell bodies in the suboesophageal ganglion, nuclei lying medial to the antennal neuropile and within the lobular plate, cell bodies in the calyx of the mushroom bodies and cell bodies in the protocerebrum. Expression is also observed in the proboscis in two cells per sensillum that are thought to be the sheath cell and the glial cell. The sacculus and a subset of cells in the olfactory sensilla show expression as well as photoreceptor cells and restricted cells in the ventral ganglion. Finally, expression is observed in the jump muscle and in hairs located all over the adult cuticle. The expression pattern was observed from in situ hybridization experiments and deduced from the enhancer trap expression pattern. The probe used does not distinguish between sd transcripts. (Campbell et al., 1992) sd transcripts are detected in RNA from embryos, larvae, and adults. (Campbell et al., 1991)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
nucleus inferred from direct assay (Goulev et al., 2008) inferred from direct assay (assigned by UniProtKB) (Simmonds et al., 1998)
Expression Deduced from Reporters
Reporter: P{GawB}sdSG29.1 Stage Tissue/Position (including subcellular localization) Reference larval stage   myoblast   (Shyamala and Chopra, 1999) third instar larval stage   wing blade | presumptive   (Shyamala and Chopra, 1999) mesothoracic tergum | presumptive   (Shyamala and Chopra, 1999) wing disc | dorsal   (Milan et al., 1997) scutellum | presumptive   (Shyamala and Chopra, 1999) wing disc | restricted   (Shyamala and Chopra, 1999) pupal stage | late   thoracic adult muscle precursor cell   (Roy et al., 1997) pupal stage -- adult stage   indirect flight muscle   (Shyamala and Chopra, 1999) adult stage   subesophageal ganglion | restricted   (Shyamala and Chopra, 1999) antennal nerve   (Shyamala and Chopra, 1999) adult brain | restricted   (Shyamala and Chopra, 1999) proboscis muscle   (Shyamala and Chopra, 1999) cibarial dilator muscle   (Shyamala and Chopra, 1999) sensory neuron of maxillary palpus   (Shyamala and Chopra, 1999) maxillary palpus | restricted   (Shyamala and Chopra, 1999) sensory neuron | subset   (Shyamala and Chopra, 1999) adult antennal lobe glomerulus   (Shyamala and Chopra, 1999) Reporter: P{lArB}sdETX4 Stage Tissue/Position (including subcellular localization) Reference embryonic stage   perineurial sheath glial cell   (Campbell et al., 1992) supraesophageal ganglion   (Campbell et al., 1992) sense organ   (Campbell et al., 1992) embryonic stage 9 -- 17   central nervous system   (Campbell et al., 1992) embryonic stage 11 -- 17   peripheral nervous system   (Campbell et al., 1992) larval stage     (Campbell et al., 1992) scutellum | precursor   (Campbell et al., 1992) maxillary palp sense organ   (Campbell et al., 1992) antennal sense organ   (Campbell et al., 1992) embryonic/larval labral segment sense organ   (Campbell et al., 1992) eye-antennal disc   (Campbell et al., 1992) anepisternum | precursor   (Campbell et al., 1992) wing disc   (Campbell et al., 1992) third instar larval stage   adepithelial cell of wing disc   (Bernard et al., 2003) pupal stage P6   dorsal medial muscle   • nucleus (Bernard et al., 2003) Comment:reference states 21 hr APF myoblast | subset   • nucleus (Bernard et al., 2003) Comment:myoblasts surrounding dorsal medial muscle; reference states 21 hr APF adult stage   microchaeta   (Campbell et al., 1992) protocerebrum   (Campbell et al., 1992) mesothoracic extracoxal depressor muscle 66   (Campbell et al., 1992) sacculus   (Campbell et al., 1992) photoreceptor cell   (Campbell et al., 1992) mushroom body calyx   (Campbell et al., 1992) subesophageal ganglion   (Campbell et al., 1992) subesophageal ganglion | restricted   (Campbell et al., 1992)
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval trachea. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult salivary gland, adult spermathecae, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    460.325 Larval Midgut    150.3 Larval Hindgut    213.2 Larval Malpighian Tubules    134.2 Larval Fat Body    46.9 Larval Salivary Gland    210.1 Larval Trachea    558.975 Larval Carcass    248.425 Adult Head    132.4 Adult Eye    312.775 Adult Brain    302.4 Adult Thoracic-Abdominal Ganglion    305.7 Adult Crop    304 Adult Midgut    133.8 Adult Hindgut    176.8 Adult Malpighian Tubules    227.7 Adult Fat Body    68.2 Adult Salivary Gland    317.2 Adult Heart    188.775 Adult VirginFemale Spermatheca    117 Adult InseminatedFemale Spermatheca    156.7 Adult Ovary    90.7 Adult Testis    82.5 Adult Male Accessory Gland    364.1 Adult Carcass    167 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    460.325 Larval Midgut    150.3 Larval Hindgut    213.2 Larval Malpighian Tubules    134.2 Larval Fat Body    46.9 Larval Salivary Gland    210.1 Larval Trachea  (558.975) Larval Carcass    248.425 Adult Head    132.4 Adult Eye    312.775 Adult Brain    302.4 Adult Thoracic-Abdominal Ganglion    305.7 Adult Crop    304 Adult Midgut    133.8 Adult Hindgut    176.8 Adult Malpighian Tubules    227.7 Adult Fat Body    68.2 Adult Salivary Gland    317.2 Adult Heart    188.775 Adult VirginFemale Spermatheca    117 Adult InseminatedFemale Spermatheca    156.7 Adult Ovary    90.7 Adult Testis    82.5 Adult Male Accessory Gland    364.1 Adult Carcass    167 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    460.325 Larval Midgut    150.3 Larval Hindgut    213.2 Larval Malpighian Tubules    134.2 Larval Fat Body    46.9 Larval Salivary Gland    210.1 Larval Trachea    558.975 Larval Carcass    248.425 Adult Head    132.4 Adult Eye    312.775 Adult Brain    302.4 Adult Thoracic-Abdominal Ganglion    305.7 Adult Crop    304 Adult Midgut    133.8 Adult Hindgut    176.8 Adult Malpighian Tubules    227.7 Adult Fat Body    68.2 Adult Salivary Gland    317.2 Adult Heart    188.775 Adult VirginFemale Spermatheca    117 Adult InseminatedFemale Spermatheca    156.7 Adult Ovary    90.7 Adult Testis    82.5 Adult Male Accessory Gland    364.1 Adult Carcass    167 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    460.325 Larval Midgut    150.3 Larval Hindgut    213.2 Larval Malpighian Tubules    134.2 Larval Fat Body    46.9 Larval Salivary Gland    210.1 Larval Trachea    558.975 Larval Carcass    248.425 Adult Head    132.4 Adult Eye    312.775 Adult Brain    302.4 Adult Thoracic-Abdominal Ganglion    305.7 Adult Crop    304 Adult Midgut    133.8 Adult Hindgut    176.8 Adult Malpighian Tubules    227.7 Adult Fat Body    68.2 Adult Salivary Gland    317.2 Adult Heart    188.775 Adult VirginFemale Spermatheca    117 Adult InseminatedFemale Spermatheca    156.7 Adult Ovary    90.7 Adult Testis    82.5 Adult Male Accessory Gland    364.1 Adult Carcass    167 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    460.325 Larval Midgut    150.3 Larval Hindgut    213.2 Larval Malpighian Tubules    134.2 Larval Fat Body    46.9 Larval Salivary Gland    210.1 Larval Trachea    558.975 Larval Carcass    248.425 Adult Head    132.4 Adult Eye    312.775 Adult Brain    302.4 Adult Thoracic-Abdominal Ganglion    305.7 Adult Crop    304 Adult Midgut    133.8 Adult Hindgut    176.8 Adult Malpighian Tubules    227.7 Adult Fat Body    68.2 Adult Salivary Gland    317.2 Adult Heart    188.775 Adult VirginFemale Spermatheca    117 Adult InseminatedFemale Spermatheca    156.7 Adult Ovary    90.7 Adult Testis    82.5 Adult Male Accessory Gland    364.1 Adult Carcass    167 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    460.325 Larval Midgut    150.3 Larval Hindgut    213.2 Larval Malpighian Tubules    134.2 Larval Fat Body    46.9 Larval Salivary Gland    210.1 Larval Trachea  558.975 Larval Carcass    248.425 Adult Head    132.4 Adult Eye    312.775 Adult Brain    302.4 Adult Thoracic-Abdominal Ganglion    305.7 Adult Crop    304 Adult Midgut    133.8 Adult Hindgut    176.8 Adult Malpighian Tubules    227.7 Adult Fat Body    68.2 Adult Salivary Gland    317.2 Adult Heart    188.775 Adult VirginFemale Spermatheca    117 Adult InseminatedFemale Spermatheca    156.7 Adult Ovary    90.7 Adult Testis    82.5 Adult Male Accessory Gland    364.1 Adult Carcass    167 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    460.325 Larval Midgut    150.3 Larval Hindgut    213.2 Larval Malpighian Tubules    134.2 Larval Fat Body    46.9 Larval Salivary Gland    210.1 Larval Trachea    558.975 Larval Carcass    248.425 Adult Head    132.4 Adult Eye    312.775 Adult Brain    302.4 Adult Thoracic-Abdominal Ganglion    305.7 Adult Crop    304 Adult Midgut    133.8 Adult Hindgut    176.8 Adult Malpighian Tubules    227.7 Adult Fat Body    68.2 Adult Salivary Gland    317.2 Adult Heart    188.775 Adult VirginFemale Spermatheca    117 Adult InseminatedFemale Spermatheca    156.7 Adult Ovary    90.7 Adult Testis    82.5 Adult Male Accessory Gland    364.1 Adult Carcass    167 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    460.325 Larval Midgut    150.3 Larval Hindgut    213.2 Larval Malpighian Tubules    134.2 Larval Fat Body    46.9 Larval Salivary Gland    210.1 Larval Trachea    558.975 Larval Carcass    248.425 Adult Head    132.4 Adult Eye    312.775 Adult Brain    302.4 Adult Thoracic-Abdominal Ganglion    305.7 Adult Crop    304 Adult Midgut    133.8 Adult Hindgut    176.8 Adult Malpighian Tubules    227.7 Adult Fat Body    68.2 Adult Salivary Gland    317.2 Adult Heart    188.775 Adult VirginFemale Spermatheca    117 Adult InseminatedFemale Spermatheca    156.7 Adult Ovary    90.7 Adult Testis    82.5 Adult Male Accessory Gland    364.1 Adult Carcass    167 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    132.4   NA  Eye    312.775   NA  Brain    302.4   460.325  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    305.7   NA  Crop    304   150.3  Midgut    133.8   213.2  Hindgut    176.8   134.2  Malpighian Tubules    227.7   no informative data  Fat Body    no informative data   210.1  Salivary Gland    317.2   NA  Heart    188.775   558.975  Trachea    NA   NA  VirginFemale Spermatheca    117   NA  InseminatedFemale Spermatheca    156.7   NA  Ovary    90.7   NA  Testis    82.5   NA  Male Accessory Gland    364.1   248.425  Carcass    167 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    29 central nervous system, larvae L3    32 central nervous system, pupae P8    17 head, virgin 1-day female    11 head, virgin 4-day female    11 head, virgin 20-day female    6 head, mated 1-day female    13 head, mated 4-day female    9 head, mated 20-day female    6 head, mated 1-day male    15 head, mated 4-day male    14 head, mated 20-day male    15 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    39 digestive system, larvae L3 wandering    12 digestive system, 1-day adult    7 digestive system, 4-day adult    8 digestive system, 20-day adult    8 fat body, larvae L3 wandering    1 fat body, white prepupae    7 fat body, pupae P8    9 carcass, larvae L3 wandering    22 carcass, 1-day adult    9 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female    7 ovary, mated 4-day female    7 testis, mated 4-day male    4 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (29) central nervous system, larvae L3  (32) central nervous system, pupae P8    17 head, virgin 1-day female    11 head, virgin 4-day female    11 head, virgin 20-day female    6 head, mated 1-day female    13 head, mated 4-day female    9 head, mated 20-day female    6 head, mated 1-day male    15 head, mated 4-day male    14 head, mated 20-day male    15 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae  (39) digestive system, larvae L3 wandering    12 digestive system, 1-day adult    7 digestive system, 4-day adult    8 digestive system, 20-day adult    8 fat body, larvae L3 wandering    1 fat body, white prepupae    7 fat body, pupae P8    9 carcass, larvae L3 wandering    22 carcass, 1-day adult    9 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female    7 ovary, mated 4-day female    7 testis, mated 4-day male    4 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    29 central nervous system, larvae L3    32 central nervous system, pupae P8    17 head, virgin 1-day female    11 head, virgin 4-day female    11 head, virgin 20-day female    6 head, mated 1-day female    13 head, mated 4-day female    9 head, mated 20-day female    6 head, mated 1-day male    15 head, mated 4-day male    14 head, mated 20-day male    15 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    39 digestive system, larvae L3 wandering    12 digestive system, 1-day adult    7 digestive system, 4-day adult    8 digestive system, 20-day adult    8 fat body, larvae L3 wandering    1 fat body, white prepupae    7 fat body, pupae P8    9 carcass, larvae L3 wandering    22 carcass, 1-day adult    9 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female    7 ovary, mated 4-day female    7 testis, mated 4-day male    4 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    29 central nervous system, larvae L3    32 central nervous system, pupae P8    17 head, virgin 1-day female    11 head, virgin 4-day female    11 head, virgin 20-day female    6 head, mated 1-day female    13 head, mated 4-day female    9 head, mated 20-day female    6 head, mated 1-day male    15 head, mated 4-day male    14 head, mated 20-day male    15 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    39 digestive system, larvae L3 wandering    12 digestive system, 1-day adult    7 digestive system, 4-day adult    8 digestive system, 20-day adult    8 fat body, larvae L3 wandering    1 fat body, white prepupae    7 fat body, pupae P8    9 carcass, larvae L3 wandering    22 carcass, 1-day adult    9 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female    7 ovary, mated 4-day female    7 testis, mated 4-day male    4 accessory gland, mated 4-day male    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    29 central nervous system, larvae L3    32 central nervous system, pupae P8    17 head, virgin 1-day female    11 head, virgin 4-day female    11 head, virgin 20-day female    6 head, mated 1-day female    13 head, mated 4-day female    9 head, mated 20-day female    6 head, mated 1-day male    15 head, mated 4-day male    14 head, mated 20-day male    15 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    39 digestive system, larvae L3 wandering    12 digestive system, 1-day adult    7 digestive system, 4-day adult    8 digestive system, 20-day adult    8 fat body, larvae L3 wandering    1 fat body, white prepupae    7 fat body, pupae P8    9 carcass, larvae L3 wandering    22 carcass, 1-day adult    9 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female    7 ovary, mated 4-day female    7 testis, mated 4-day male    4 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  29 central nervous system, larvae L3  32 central nervous system, pupae P8    17 head, virgin 1-day female    11 head, virgin 4-day female    11 head, virgin 20-day female    6 head, mated 1-day female    13 head, mated 4-day female    9 head, mated 20-day female    6 head, mated 1-day male    15 head, mated 4-day male    14 head, mated 20-day male    15 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae  (39) digestive system, larvae L3 wandering    12 digestive system, 1-day adult    7 digestive system, 4-day adult    8 digestive system, 20-day adult    8 fat body, larvae L3 wandering    1 fat body, white prepupae    7 fat body, pupae P8    9 carcass, larvae L3 wandering    22 carcass, 1-day adult    9 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female    7 ovary, mated 4-day female    7 testis, mated 4-day male    4 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    29 central nervous system, larvae L3    32 central nervous system, pupae P8    17 head, virgin 1-day female    11 head, virgin 4-day female    11 head, virgin 20-day female    6 head, mated 1-day female    13 head, mated 4-day female    9 head, mated 20-day female    6 head, mated 1-day male    15 head, mated 4-day male    14 head, mated 20-day male    15 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    39 digestive system, larvae L3 wandering    12 digestive system, 1-day adult    7 digestive system, 4-day adult    8 digestive system, 20-day adult    8 fat body, larvae L3 wandering    1 fat body, white prepupae    7 fat body, pupae P8    9 carcass, larvae L3 wandering    22 carcass, 1-day adult    9 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female    7 ovary, mated 4-day female    7 testis, mated 4-day male    4 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    29 central nervous system, larvae L3    32 central nervous system, pupae P8    17 head, virgin 1-day female    11 head, virgin 4-day female    11 head, virgin 20-day female    6 head, mated 1-day female    13 head, mated 4-day female    9 head, mated 20-day female    6 head, mated 1-day male    15 head, mated 4-day male    14 head, mated 20-day male    15 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    39 digestive system, larvae L3 wandering    12 digestive system, 1-day adult    7 digestive system, 4-day adult    8 digestive system, 20-day adult    8 fat body, larvae L3 wandering    1 fat body, white prepupae    7 fat body, pupae P8    9 carcass, larvae L3 wandering    22 carcass, 1-day adult    9 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female    7 ovary, mated 4-day female    7 testis, mated 4-day male    4 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 06-18 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    4 embryo 04-06hr    16 embryo 06-08hr    27 embryo 08-10hr    34 embryo 10-12hr    35 embryo 12-14hr    32 embryo 14-16hr    13 embryo 16-18hr    14 embryo 18-20hr    11 embryo 20-22hr    9 embryo 22-24hr    12 larva L1    8 larva L2    6 larva L3 12hr old    7 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    17 white prepupae new    19 white prepupae 12hr    16 white prepupae 24hr    22 pupae 2d postWPP    14 pupae 3d postWPP    10 pupae 4d postWPP    7 adult male 01day    7 adult male 05day    7 adult male 30day    8 adult female 01day    6 adult female 05day    5 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    4 embryo 04-06hr    16 embryo 06-08hr  (27) embryo 08-10hr  (34) embryo 10-12hr  (35) embryo 12-14hr  (32) embryo 14-16hr    13 embryo 16-18hr    14 embryo 18-20hr    11 embryo 20-22hr    9 embryo 22-24hr    12 larva L1    8 larva L2    6 larva L3 12hr old    7 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    17 white prepupae new    19 white prepupae 12hr    16 white prepupae 24hr    22 pupae 2d postWPP    14 pupae 3d postWPP    10 pupae 4d postWPP    7 adult male 01day    7 adult male 05day    7 adult male 30day    8 adult female 01day    6 adult female 05day    5 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    4 embryo 04-06hr    16 embryo 06-08hr    27 embryo 08-10hr    34 embryo 10-12hr    35 embryo 12-14hr    32 embryo 14-16hr    13 embryo 16-18hr    14 embryo 18-20hr    11 embryo 20-22hr    9 embryo 22-24hr    12 larva L1    8 larva L2    6 larva L3 12hr old    7 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    17 white prepupae new    19 white prepupae 12hr    16 white prepupae 24hr    22 pupae 2d postWPP    14 pupae 3d postWPP    10 pupae 4d postWPP    7 adult male 01day    7 adult male 05day    7 adult male 30day    8 adult female 01day    6 adult female 05day    5 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    4 embryo 04-06hr    16 embryo 06-08hr    27 embryo 08-10hr    34 embryo 10-12hr    35 embryo 12-14hr    32 embryo 14-16hr    13 embryo 16-18hr    14 embryo 18-20hr    11 embryo 20-22hr    9 embryo 22-24hr    12 larva L1    8 larva L2    6 larva L3 12hr old    7 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    17 white prepupae new    19 white prepupae 12hr    16 white prepupae 24hr    22 pupae 2d postWPP    14 pupae 3d postWPP    10 pupae 4d postWPP    7 adult male 01day    7 adult male 05day    7 adult male 30day    8 adult female 01day    6 adult female 05day    5 adult female 30day    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    4 embryo 04-06hr    16 embryo 06-08hr    27 embryo 08-10hr    34 embryo 10-12hr    35 embryo 12-14hr    32 embryo 14-16hr    13 embryo 16-18hr    14 embryo 18-20hr    11 embryo 20-22hr    9 embryo 22-24hr    12 larva L1    8 larva L2    6 larva L3 12hr old    7 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    17 white prepupae new    19 white prepupae 12hr    16 white prepupae 24hr    22 pupae 2d postWPP    14 pupae 3d postWPP    10 pupae 4d postWPP    7 adult male 01day    7 adult male 05day    7 adult male 30day    8 adult female 01day    6 adult female 05day    5 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    4 embryo 04-06hr    16 embryo 06-08hr  27 embryo 08-10hr  (34) embryo 10-12hr  (35) embryo 12-14hr  32 embryo 14-16hr    13 embryo 16-18hr    14 embryo 18-20hr    11 embryo 20-22hr    9 embryo 22-24hr    12 larva L1    8 larva L2    6 larva L3 12hr old    7 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    17 white prepupae new    19 white prepupae 12hr    16 white prepupae 24hr    22 pupae 2d postWPP    14 pupae 3d postWPP    10 pupae 4d postWPP    7 adult male 01day    7 adult male 05day    7 adult male 30day    8 adult female 01day    6 adult female 05day    5 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    4 embryo 04-06hr    16 embryo 06-08hr    27 embryo 08-10hr    34 embryo 10-12hr    35 embryo 12-14hr    32 embryo 14-16hr    13 embryo 16-18hr    14 embryo 18-20hr    11 embryo 20-22hr    9 embryo 22-24hr    12 larva L1    8 larva L2    6 larva L3 12hr old    7 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    17 white prepupae new    19 white prepupae 12hr    16 white prepupae 24hr    22 pupae 2d postWPP    14 pupae 3d postWPP    10 pupae 4d postWPP    7 adult male 01day    7 adult male 05day    7 adult male 30day    8 adult female 01day    6 adult female 05day    5 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    4 embryo 04-06hr    16 embryo 06-08hr    27 embryo 08-10hr    34 embryo 10-12hr    35 embryo 12-14hr    32 embryo 14-16hr    13 embryo 16-18hr    14 embryo 18-20hr    11 embryo 20-22hr    9 embryo 22-24hr    12 larva L1    8 larva L2    6 larva L3 12hr old    7 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    17 white prepupae new    19 white prepupae 12hr    16 white prepupae 24hr    22 pupae 2d postWPP    14 pupae 3d postWPP    10 pupae 4d postWPP    7 adult male 01day    7 adult male 05day    7 adult male 30day    8 adult female 01day    6 adult female 05day    5 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    24 embryonic 1182-4H    24 embryonic GM2    50 embryonic Kc167    34 embryonic S1    49 embryonic S3    13 leg disc CME L1    23 wing disc CME-W2    25 wing disc ML-DmD8    24 wing disc ML-DmD9    38 wing disc ML-DmD16-c3    35 wing disc ML-DmD21    26 wing disc ML-DmD32    44 haltere disc ML-DmD17-c3    34 eye-antennal disc ML-DmD11    34 antennal disc ML-DmD20-c5    25 mixed discs ML-DmD4-c1    26 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    24 tumorous blood cells mbn2    28 ovary fGS/OSS    60 ovary OSC    38 ovary OSS    44 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    24 embryonic 1182-4H    24 embryonic GM2  (50) embryonic Kc167  (34) embryonic S1  (49) embryonic S3    13 leg disc CME L1    23 wing disc CME-W2    25 wing disc ML-DmD8    24 wing disc ML-DmD9  (38) wing disc ML-DmD16-c3  (35) wing disc ML-DmD21  26 wing disc ML-DmD32  (44) haltere disc ML-DmD17-c3  (34) eye-antennal disc ML-DmD11  (34) antennal disc ML-DmD20-c5    25 mixed discs ML-DmD4-c1  26 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    24 tumorous blood cells mbn2  (28) ovary fGS/OSS  (60) ovary OSC  (38) ovary OSS  (44) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    24 embryonic 1182-4H    24 embryonic GM2    50 embryonic Kc167    34 embryonic S1    49 embryonic S3    13 leg disc CME L1    23 wing disc CME-W2    25 wing disc ML-DmD8    24 wing disc ML-DmD9    38 wing disc ML-DmD16-c3    35 wing disc ML-DmD21    26 wing disc ML-DmD32    44 haltere disc ML-DmD17-c3    34 eye-antennal disc ML-DmD11    34 antennal disc ML-DmD20-c5    25 mixed discs ML-DmD4-c1    26 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    24 tumorous blood cells mbn2    28 ovary fGS/OSS    60 ovary OSC    38 ovary OSS    44 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    24 embryonic 1182-4H    24 embryonic GM2    50 embryonic Kc167    34 embryonic S1    49 embryonic S3    13 leg disc CME L1    23 wing disc CME-W2    25 wing disc ML-DmD8    24 wing disc ML-DmD9    38 wing disc ML-DmD16-c3    35 wing disc ML-DmD21    26 wing disc ML-DmD32    44 haltere disc ML-DmD17-c3    34 eye-antennal disc ML-DmD11    34 antennal disc ML-DmD20-c5    25 mixed discs ML-DmD4-c1    26 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    24 tumorous blood cells mbn2    28 ovary fGS/OSS    60 ovary OSC    38 ovary OSS    44 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    24 embryonic 1182-4H    24 embryonic GM2    50 embryonic Kc167    34 embryonic S1    49 embryonic S3    13 leg disc CME L1    23 wing disc CME-W2    25 wing disc ML-DmD8    24 wing disc ML-DmD9    38 wing disc ML-DmD16-c3    35 wing disc ML-DmD21    26 wing disc ML-DmD32    44 haltere disc ML-DmD17-c3    34 eye-antennal disc ML-DmD11    34 antennal disc ML-DmD20-c5    25 mixed discs ML-DmD4-c1    26 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    24 tumorous blood cells mbn2    28 ovary fGS/OSS    60 ovary OSC    38 ovary OSS    44 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    24 embryonic 1182-4H    24 embryonic GM2  (50) embryonic Kc167  (34) embryonic S1  (49) embryonic S3    13 leg disc CME L1    23 wing disc CME-W2    25 wing disc ML-DmD8    24 wing disc ML-DmD9  (38) wing disc ML-DmD16-c3  (35) wing disc ML-DmD21  26 wing disc ML-DmD32  (44) haltere disc ML-DmD17-c3  (34) eye-antennal disc ML-DmD11  (34) antennal disc ML-DmD20-c5    25 mixed discs ML-DmD4-c1  26 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    24 tumorous blood cells mbn2  28 ovary fGS/OSS  (60) ovary OSC  (38) ovary OSS  (44) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    24 embryonic 1182-4H    24 embryonic GM2    50 embryonic Kc167    34 embryonic S1    49 embryonic S3    13 leg disc CME L1    23 wing disc CME-W2    25 wing disc ML-DmD8    24 wing disc ML-DmD9    38 wing disc ML-DmD16-c3    35 wing disc ML-DmD21    26 wing disc ML-DmD32    44 haltere disc ML-DmD17-c3    34 eye-antennal disc ML-DmD11    34 antennal disc ML-DmD20-c5    25 mixed discs ML-DmD4-c1    26 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    24 tumorous blood cells mbn2    28 ovary fGS/OSS    60 ovary OSC    38 ovary OSS    44 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    24 embryonic 1182-4H    24 embryonic GM2    50 embryonic Kc167    34 embryonic S1    49 embryonic S3    13 leg disc CME L1    23 wing disc CME-W2    25 wing disc ML-DmD8    24 wing disc ML-DmD9    38 wing disc ML-DmD16-c3    35 wing disc ML-DmD21    26 wing disc ML-DmD32    44 haltere disc ML-DmD17-c3    34 eye-antennal disc ML-DmD11    34 antennal disc ML-DmD20-c5    25 mixed discs ML-DmD4-c1    26 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    24 tumorous blood cells mbn2    28 ovary fGS/OSS    60 ovary OSC    38 ovary OSS    44 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    13 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    19 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    11 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    13 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    19 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    11 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    13 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    19 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    11 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    13 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    19 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    11 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    13 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    19 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    11 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    13 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    19 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    11 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    13 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    19 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    11 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    13 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    19 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    11 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_11 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • RE23308 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003345 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8544-RB FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for sd Stages(s) 1-3 Stages(s) 4-6 Stages(s) 9-10 Stages(s) 11-12
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | larval stage sd9 sd12 sdG0262 sdG0315b sdG0483 lethal | larval stage | recessive sd9 sd12 lethal | pharate adult stage sdG0239 sdG0262 lethal | prepupal stage sdG0262 sdG0315b lethal | pupal stage sdG0262 sdG0300 sdG0309 sdG0315b lethal | pupal stage, with Scer\GAL4ptc-559.1 sdScer\UAS.cSa lethal | pupal stage | recessive sd10 sd11 sd13 sdETX81 lethal | recessive sd9 sd10 sd11 sd12 sd13 sdg6 sdG0239 sdG0262 sdG0309 sdG0315b sdG0483 sdS278 partially lethal - majority die | pupal stage, with Scer\GAL4Mef2.PR sdΔ88-159.Scer\UAS partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 sdGD4744 viable sd2 sdCA07575 sdE3 sdETX4 sdjP sdsp sdts viable (with sdETX81) sdSG29.1 viable (with sdSG29.1) sdETX81 Sterility Allele female fertile sdsp fertile sd2 sdE3 male fertile sdsp male sterile sds Other Phenotypes Allele chemosensitive behavior defective sdE3 sdts chemosensitive behavior defective | recessive sdETX4 sdex-3 sdex-11 decreased cell number | third instar larval stage, with Scer\GAL4repo.PU sdKK108877 developmental rate defective sdUCI increased cell death, with Scer\GAL4ptc-559.1 sdScer\UAS.cSa sdΔ200.Scer\UAS mitotic cell cycle defective sd58d size defective, with Scer\GAL4GMR.PF sdScer\UAS.cSa size defective, with Scer\GAL4vg.PU sdScer\UAS.cSa stress response defective sdBG02605 taste perception defective | recessive sdETX4 visible sd1 sd2 sd58d sdCMM1 sdCMM2 sdE3 sdETX4 sdjP sdR-7 sdR-11 sdR-12 sdR-14 sdR-15 sdR-39 sdR-49 sdR-50 sdR-57 sdR-58 sdR-59 sdR-68 sdR-69 sdR-83 sdR-84 sdR-90 sdR-95 sdR-96 sdR-99 sdR-106 sdR-107 sdR-111 sdR-113 sdR-115 sdR-117 sdR-118 sdR-119 sdR-122 sdSG29.1 sdUCI visible, with rprScer\UAS.cVa sd213-440.hs.T:Scer\GAL4 visible, with Scer\GAL4ap-md544 sdEP1088 sdEP1435 visible, with Scer\GAL4ey.PH sddsRNA.C.Scer\UAS sddsRNA.N.Scer\UAS visible, with Scer\GAL4ey.PH, sddsRNA.C.Scer\UAS sddsRNA.N.Scer\UAS visible, with Scer\GAL4ey.PH, sddsRNA.N.Scer\UAS sddsRNA.C.Scer\UAS visible, with Scer\GAL4GMR.PF sdGA.Scer\UAS.T:Scer\GAL4-GAD sdScer\UAS.cSa visible, with Scer\GAL4pnr-MD237 sdGD4744 visible, with Scer\GAL4ptc-559.1 sdScer\UAS.cSa sdScer\UAS.cVa sdΔ200.Scer\UAS visible, with Scer\GAL4sca-537.4 sdEP1435 visible, with Scer\GAL4vg.int2.1 sdScer\UAS.cVa visible, with Scer\GAL4vg.int2.1, sd58d sdScer\UAS.cVa visible, with Scer\GAL4vg.int2.1, sdScer\UAS.cVa sd58d visible, with Scer\GAL4vg.PU sdScer\UAS.cSa visible (with Df(1)Exel6251) sd1 visible (with sd1) sdΔB sdΔC visible (with sd9) sdETX4 visible (with sd11) sdETX4 visible (with sd12) sdETX4 visible (with sd13) sdETX4 visible (with sd58d) sdETX4 visible (with sdETX4) sd9 sd11 sd12 sd13 sd58d sdSG29.1 visible (with sdSG29.1) sdETX4 visible (with sdΔB) sd1 visible (with sdΔC) sd1 visible | dominant sd11 sdE3 sdSG29.1 visible | heat sensitive sdCMM2 visible | heat sensitive, with Scer\GAL4dpp.blk1 sdScer\UAS.cSa visible | recessive sd1 sd48b sd58a sd58d sd91a sd103b sd109a sd115a sd115b sd194b sd215a sd232a sd232b sd267a sd311a sd330a sd330b sd338b sd358b sdETX4 sdex-3 sdex-11 sdFab-X sdry2216-853 sdry+ sdSG29.1 sdsp visible | recessive | heat sensitive sdts visible | recessive | somatic clone sd12 wild-type sdex-2 sdex-5 sdex-6 sdex-7 sdex-9 sdhs.PC Phenotype manifest in Allele A1-7 dorsal acute muscle 1, with Scer\GAL4Mef2.PR sdΔ88-159.Scer\UAS A1-7 lateral longitudinal muscle 1, with Scer\GAL4Mef2.PR sdScer\UAS.T:Zzzz\FLAG A1-7 ventral longitudinal muscle 1, with Scer\GAL4Mef2.PR sdScer\UAS.T:Zzzz\FLAG A1-7 ventral longitudinal muscle 2, with Scer\GAL4Mef2.PR sdScer\UAS.T:Zzzz\FLAG A1-7 ventral oblique muscle 4 sd9 A1-7 ventral oblique muscle 4, with Scer\GAL4Mef2.PR sdScer\UAS.T:Zzzz\FLAG A1-7 ventral oblique muscle 5 sd9 A1-7 ventral oblique muscle 5, with Scer\GAL4Mef2.PR sdScer\UAS.T:Zzzz\FLAG A1-7 ventral oblique muscle 6 sd9 A1-7 ventral oblique muscle 6, with Scer\GAL4Mef2.PR sdScer\UAS.T:Zzzz\FLAG adult, with Scer\GAL4sd-SG29.1 sdΔ88-159.Scer\UAS adult head, with Scer\GAL4ptc-559.1 sdScer\UAS.cSa adult thorax, with Scer\GAL4ap-md544 sdEP1088 capitellum sdETX4 chaeta, with Scer\GAL4ap-md544 sdEP1088 crossvein, with Scer\GAL4vg.int2.1 sdScer\UAS.cVa crossvein, with Scer\GAL4vg.int2.1, sd58d sdScer\UAS.cVa crossvein, with Scer\GAL4vg.int2.1, sdScer\UAS.cVa sd58d embryonic/larval cardial cell sd9 embryonic/larval cardial cell, with Scer\GAL4Mef2.PR sdScer\UAS.T:Zzzz\FLAG eye sd1 eye, with Scer\GAL4ey.PH sddsRNA.N.Scer\UAS sddsRNA.C.Scer\UAS eye, with Scer\GAL4ey.PH, sddsRNA.C.Scer\UAS sddsRNA.N.Scer\UAS eye, with Scer\GAL4ey.PH, sddsRNA.N.Scer\UAS sddsRNA.C.Scer\UAS eye, with Scer\GAL4GMR.PF sdGA.Scer\UAS.T:Scer\GAL4-GAD sdScer\UAS.cSa eye, with Scer\GAL4ptc-559.1 sdΔ200.Scer\UAS sdScer\UAS.cSa eye disc | third instar larval stage, with Scer\GAL4repo.PU sdKK108877 haltere sd1 sd58d sdUCI sdry+ head | P-stage sd10 sd11 indirect flight muscle sd13 indirect flight muscle, with Scer\GAL41151 sdScer\UAS.cSa interommatidial bristle, with Scer\GAL4ptc-559.1 sdΔ200.Scer\UAS interommatidial bristle | ectopic, with Scer\GAL4ptc-559.1 sdΔ200.Scer\UAS interommatidial bristle | ectopic | somatic clone sd12 interommatidial bristle | somatic clone sd12 lamina, with Scer\GAL4ptc-559.1 sdScer\UAS.cSa leg, with Scer\GAL4ptc-559.1 sdScer\UAS.cSa leg | ectopic, with Scer\GAL4ptc-559.1 sdΔ200.Scer\UAS leg | somatic clone sd12 lobula plate, with Scer\GAL4ptc-559.1 sdScer\UAS.cSa macrochaeta sdBG02605 macrochaeta & wing sd58d sdry2216-853 macrochaeta | ectopic sd1 sd2 macrochaeta | ectopic, with Scer\GAL4sca-537.4 sdEP1435 mesothoracic tergum, with Scer\GAL4pnr-MD237 sdGD4744 metathoracic laterotergite sdUCI microchaeta, with Scer\GAL4ap-md544 sdEP1435 microchaeta, with Scer\GAL4sca-537.4 sdEP1435 midgut constriction, with Scer\GAL4Mef2.PR sdScer\UAS.T:Zzzz\FLAG ommatidium, with Scer\GAL4ptc-559.1 sdΔ200.Scer\UAS posterior scutellar bristle sd1 sdUCI posterior wing margin sdSG29.1 pupa, with Scer\GAL4sd-SG29.1 sdΔ88-159.Scer\UAS scutellar bristle sdry+ scutellum, with Scer\GAL4ap-md544 sdEP1088 somatic muscle, with Scer\GAL4Mef2.PR sdΔ88-159.Scer\UAS unguis | somatic clone sd12 ventral thoracic disc, with Scer\GAL4ptc-559.1 sdΔ200.Scer\UAS wing sd1 sd103b sd109a sd11 sd115a sd115b sd13 sd194b sd2 sd215a sd232a sd232b sd267a sd311a sd330a sd330b sd338b sd358b sd48b sd5 sd58a sd58d sd62l sd91a sdCMM1 sdCMM2 sdE3 sdETX4 sdFab-X sdR-106 sdR-107 sdR-11 sdR-111 sdR-113 sdR-115 sdR-117 sdR-118 sdR-119 sdR-12 sdR-122 sdR-14 sdR-15 sdR-39 sdR-49 sdR-50 sdR-57 sdR-58 sdR-59 sdR-68 sdR-69 sdR-7 sdR-83 sdR-84 sdR-90 sdR-95 sdR-96 sdR-99 sdSG29.1 sdUCI sdex-11 sdex-3 sdjP sdry+ sds sdsp wing, with rprScer\UAS.cVa sd213-440.hs.T:Scer\GAL4 wing, with Scer\GAL4ap-md544 sdEP1088 wing, with Scer\GAL4ptc-559.1 sdΔ200.Scer\UAS sdScer\UAS.cVa wing, with Scer\GAL4sd-SG29.1 sdΔ88-159.Scer\UAS wing, with Scer\GAL4vg.boundary sdΔ160-219.Scer\UAS sdΔ200.Scer\UAS sdΔ88-159.Scer\UAS wing, with Scer\GAL4vg.boundary, sd58d sdΔ124-159.Scer\UAS sdΔ160-219.Scer\UAS sdΔ200.Scer\UAS sdΔ88-123.Scer\UAS sdΔ88-159.Scer\UAS wing, with Scer\GAL4vg.boundary, sdETX4 sdΔ124-159.Scer\UAS sdΔ160-219.Scer\UAS sdΔ200.Scer\UAS sdΔ88-123.Scer\UAS sdΔ88-159.Scer\UAS wing, with Scer\GAL4vg.boundary, sdΔ88-123.Scer\UAS sd58d sdETX4 wing, with Scer\GAL4vg.boundary, sdΔ88-159.Scer\UAS sd58d sdETX4 wing, with Scer\GAL4vg.boundary, sdΔ124-159.Scer\UAS sd58d sdETX4 wing, with Scer\GAL4vg.boundary, sdΔ160-219.Scer\UAS sd58d sdETX4 wing, with Scer\GAL4vg.boundary, sdΔ200.Scer\UAS sd58d sdETX4 wing, with Scer\GAL4vg.int2.1 sdScer\UAS.cVa wing, with Scer\GAL4vg.int2.1, sd58d sdScer\UAS.cVa wing, with Scer\GAL4vg.int2.1, sdScer\UAS.cVa sd58d wing, with Scer\GAL4vg.PU sdScer\UAS.cSa wing (with Df(1)Exel6251) sd1 wing (with sd1) sdΔB sdΔC wing (with sd9) sdETX4 wing (with sd11) sdETX4 wing (with sd12) sdETX4 wing (with sd13) sdETX4 wing (with sd58d) sdETX4 wing (with sdETX4) sd11 sd12 sd13 sd58d sd9 sdSG29.1 wing (with sdSG29.1) sdETX4 wing (with sdΔB) sd1 wing (with sdΔC) sd1 wing & macrochaeta sd1 wing | anterior sdE3 wing | heat sensitive sdCMM2 wing | heat sensitive, with Scer\GAL4dpp.blk1 sdScer\UAS.cSa wing | heat sensitive, with Scer\GAL4vg.boundary, sd58d sdΔ87.Scer\UAS sdScer\UAS.cSa wing | heat sensitive, with Scer\GAL4vg.boundary, sdETX4 sdΔ87.Scer\UAS sdScer\UAS.cSa wing | heat sensitive, with Scer\GAL4vg.boundary, sdScer\UAS.cSa sd58d sdETX4 wing | heat sensitive, with Scer\GAL4vg.boundary, sdΔ87.Scer\UAS sd58d sdETX4 wing | P-stage sd1 sd11 wing blade sdFab-X wing blade, with Scer\GAL4ptc-559.1 sdΔ200.Scer\UAS wing blade, with Scer\GAL4vg.int2.1 sdScer\UAS.cVa wing blade, with Scer\GAL4vg.int2.1, sd58d sdScer\UAS.cVa wing blade, with Scer\GAL4vg.int2.1, sdScer\UAS.cVa sd58d wing disc sd58d sdETX81 sdUCI wing disc, with Scer\GAL4dpp.blk1 sdScer\UAS.cVa wing disc, with Scer\GAL4hh-Gal4, sddsRNA.C.Scer\UAS sddsRNA.N.Scer\UAS wing disc, with Scer\GAL4hh-Gal4, sddsRNA.N.Scer\UAS sddsRNA.C.Scer\UAS wing disc, with Scer\GAL4ptc-559.1 sdΔ200.Scer\UAS sdScer\UAS.cVa wing disc, with Scer\GAL4vg.int2.1 sdScer\UAS.cVa wing disc | somatic clone sd12 sd58d wing disc | somatic clone, with Scer\GAL4Act5C.PI sdScer\UAS.cSa wing hinge, with Scer\GAL4vg.int2.1 sdScer\UAS.cVa wing hinge, with Scer\GAL4vg.int2.1, sd58d sdScer\UAS.cVa wing hinge, with Scer\GAL4vg.int2.1, sdScer\UAS.cVa sd58d wing margin sd1 sd2 sdETX4 sdUCI wing margin (with sd9) sdETX4 wing margin (with sd11) sdETX4 wing margin (with sd12) sdETX4 wing margin (with sd13) sdETX4 wing margin (with sdETX4) sd11 sd12 sd13 sd9 wing pouch | somatic clone sdΔB wing sensillum sdETX4 wing vein sd1 sd2 sd3 sd4 sd5 sd6 sd7 sd8 sdry+ wing vein, with Scer\GAL4vg.int2.1 sdScer\UAS.cVa wing vein, with Scer\GAL4vg.int2.1, sd58d sdScer\UAS.cVa wing vein, with Scer\GAL4vg.int2.1, sdScer\UAS.cVa sd58d wing vein & macrochaeta sd2 wing vein | ectopic, with rprScer\UAS.cVa sd213-440.hs.T:Scer\GAL4 wing vein L2, with rprScer\UAS.cVa sd213-440.hs.T:Scer\GAL4 wing vein L4, with rprScer\UAS.cVa sd213-440.hs.T:Scer\GAL4 wing vein L5, with rprScer\UAS.cVa sd213-440.hs.T:Scer\GAL4
Classical Alleles ( 178 )
For All Classical Alleles Show
Allele of sd Class Mutagen Stocks Known lesion sd1 hypomorphic allele - genetic evidence X ray 17 -- sdG0239 P-element activity 2 -- sdG0262 P-element activity 2 -- sdG0309 P-element activity 2 -- sdG0315b P-element activity 2 -- sdG0483 P-element activity 2 -- sd11 hypomorphic allele - genetic evidence ethyl methanesulfonate 1 Yes sd12 ethyl methanesulfonate 1 Yes sd2 hypomorphic allele - genetic evidence X ray 1 -- sd5-HA-1903 1 -- sd5-HA-2741 1 -- sd58d hypomorphic allele - genetic evidence gamma ray 1 -- sdCB-0135-3 1 -- sdCB-5372-3 1 -- sdCB-5790-3 1 -- sdCB-6764-3 1 -- sdCB-6939-3 1 -- sdd01505 1 -- sdd04263 P-element activity 1 -- sde00587 1 -- sde02321 piggyBac transposase 1 -- sde04539 1 -- sdE3 PM hybrid dysgenesis P-element activity 1 Yes sdEP1088 P-element activity 1 Yes sdETX4 loss of function allele, hypomorphic allele - genetic evidence Delta2-3 P-element activity 1 Yes sdEY10259 1 -- sdf04046 piggyBac transposase 1 -- sdf04484 piggyBac transposase 1 -- sdf06474 piggyBac transposase 1 -- sdKG04449 1 -- sdNP0274 1 -- sdNP0654 1 -- sdNP0759 1 -- sdNP0790 1 -- sdNP0975 1 -- sdNP1035 1 -- sdNP1090 1 -- sdNP1521 1 -- sdNP2014 1 -- sdNP2542 1 -- sdNP4066 1 -- sdNP5124 1 -- sdNP7148 1 -- sdNP7192 1 -- sdNP7222 1 -- sdNP7228 1 -- sdSG29.1 P-element activity 1 Yes sdg6 amorphic allele - genetic evidence gamma ray 0 -- sd+109b Delta2-3 0 Yes sd+175a Delta2-3 0 Yes sd+175b Delta2-3 0 Yes sd+215b Delta2-3 0 Yes sd+231a Delta2-3 0 Yes sd+231b Delta2-3 0 Yes sd+239b Delta2-3 0 Yes sd+253b Delta2-3 0 Yes sd+263b Delta2-3 0 Yes sd+267b Delta2-3 0 Yes sd+292b Delta2-3 0 Yes sd+311b Delta2-3 0 Yes sd+358a Delta2-3 0 Yes sd+422a Delta2-3 0 Yes sd+422b Delta2-3 0 Yes sd+58b Delta2-3 0 Yes sd+91b Delta2-3 0 Yes sd103b Delta2-3 0 Yes sd109a Delta2-3 0 Yes sd10 ethyl methanesulfonate 0 Yes sd115a Delta2-3 0 Yes sd115b Delta2-3 0 Yes sd13 ethyl methanesulfonate 0 Yes sd14 PM hybrid dysgenesis P-element activity 0 Yes sd15 PM hybrid dysgenesis 0 -- sd194b Delta2-3 0 Yes sd215a Delta2-3 0 Yes sd232a Delta2-3 0 Yes sd232b Delta2-3 0 Yes sd267a Delta2-3 0 Yes sd311a Delta2-3 0 Yes sd330a Delta2-3 0 Yes sd330b Delta2-3 0 Yes sd338b Delta2-3 0 Yes sd358b Delta2-3 0 Yes sd35 0 -- sd3 PM hybrid dysgenesis 0 Yes sd409b Delta2-3 0 Yes sd48b Delta2-3 0 Yes sd4 PM hybrid dysgenesis 0 Yes sd56j X ray 0 -- sd58a Delta2-3 0 Yes sd5 PM hybrid dysgenesis 0 Yes sd62l 0 -- sd6 PM hybrid dysgenesis 0 Yes sd7 PM hybrid dysgenesis 0 Yes sd8 PM hybrid dysgenesis 0 Yes sd91a Delta2-3 0 Yes sd9 ethyl methanesulfonate 0 Yes sdBG02605 P-element activity 0 Yes sdBL1 PM hybrid dysgenesis 0 -- sdCA07575 P-element activity 0 Yes sdCMM1 P-element activity 0 -- sdCMM2 P-element activity 0 Yes sdd09376 P-element activity 0 -- sdEP1188 P-element activity 0 Yes sdEP1435 P-element activity 0 Yes sdETX81 loss of function allele Delta2-3 P-element activity 0 Yes sdex-11 Delta2-3 0 -- sdex-2 Delta2-3 0 Yes sdex-3 Delta2-3 0 -- sdex-5 Delta2-3 0 Yes sdex-6 Delta2-3 0 Yes sdex-7 Delta2-3 0 Yes sdex-9 Delta2-3 0 Yes sdf06088 piggyBac transposase 0 -- sdFab-X P-element activity 0 Yes sdG0300 P-element activity 0 -- sdGG01029 0 -- sdGG01101 0 -- sdGG01829 0 -- sdjP transposable element activity 0 -- sdM1.A P-element activity 0 Yes sdM19 P-element activity 0 Yes sdM20 P-element activity 0 Yes sdM21 P-element activity 0 Yes sdM26 P-element activity 0 Yes sdM27 P-element activity 0 Yes sdM28 P-element activity 0 Yes sdM2 P-element activity 0 Yes sdM3 P-element activity 0 Yes sdR-106 PM hybrid dysgenesis 0 Yes sdR-107 PM hybrid dysgenesis 0 Yes sdR-111 PM hybrid dysgenesis 0 Yes sdR-113 PM hybrid dysgenesis 0 Yes sdR-115 PM hybrid dysgenesis 0 Yes sdR-117 PM hybrid dysgenesis 0 Yes sdR-118 PM hybrid dysgenesis 0 Yes sdR-119 PM hybrid dysgenesis 0 Yes sdR-11 PM hybrid dysgenesis 0 Yes sdR-122 PM hybrid dysgenesis 0 Yes sdR-12 PM hybrid dysgenesis 0 Yes sdR-14 PM hybrid dysgenesis 0 Yes sdR-15 PM hybrid dysgenesis 0 Yes sdR-39 PM hybrid dysgenesis 0 Yes sdR-49 PM hybrid dysgenesis 0 Yes sdR-50 PM hybrid dysgenesis 0 Yes sdR-57 PM hybrid dysgenesis 0 Yes sdR-58 PM hybrid dysgenesis 0 Yes sdR-59 PM hybrid dysgenesis 0 Yes sdR-68 PM hybrid dysgenesis 0 Yes sdR-69 PM hybrid dysgenesis 0 Yes sdR-7 PM hybrid dysgenesis 0 Yes sdR-83 PM hybrid dysgenesis 0 Yes sdR-84 PM hybrid dysgenesis 0 Yes sdR-90 PM hybrid dysgenesis 0 Yes sdR-95 PM hybrid dysgenesis 0 Yes sdR-96 PM hybrid dysgenesis 0 Yes sdR-99 PM hybrid dysgenesis 0 Yes sdry+ PM hybrid dysgenesis P-element activity 0 Yes sdry2216-547 PM hybrid dysgenesis 0 Yes sdry2216-853 PM hybrid dysgenesis 0 -- sdS278 P-element activity 0 Yes sds X ray 0 -- sdsp X ray 0 -- sdts ethyl methanesulfonate 0 -- sdUCI 0 -- sdunspecified 0 -- sdwa P-element activity 0 Yes sdWT10 P-element activity 0 Yes sdWT11 P-element activity 0 Yes sdWT12 P-element activity 0 Yes sdWT13 P-element activity 0 Yes sdWT1 P-element activity 0 Yes sdWT2 P-element activity 0 Yes sdWT3 P-element activity 0 Yes sdWT8 P-element activity 0 Yes sdWT9 P-element activity 0 Yes sdΔB FLPase 0 Yes sdΔC FLPase 0 Yes
Alleles Carried on Transgenic Constructs ( 25 )
For All Alleles Carried on Transgenic Constructs Show
Allele of sd Class Mutagen Stocks Known lesion sdScer\UAS.cSa in vitro construct - regulatory fusion 2 Yes sdGD4744 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes sdGL00410 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes sdJF02514 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes sdKK108877 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes sd213-440.hs.T:Scer\GAL4 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes sdAct5C.PH in vitro construct - regulatory fusion 0 Yes sddsRNA.C.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes sddsRNA.N.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes sdGA.Scer\UAS.T:Scer\GAL4-GAD in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes sdhs.PC in vitro construct - regulatory fusion 0 Yes sdNIG.8544R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes sdScer\UAS.cVa in vitro construct - regulatory fusion 0 Yes sdScer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes sdScer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes sdΔ124-159.Scer\UAS in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes sdΔ160-219.Scer\UAS in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes sdΔ200.Scer\UAS in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes sdΔ220-281.Scer\UAS in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes sdΔ220-344.Scer\UAS in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes sdΔ282-344.Scer\UAS in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes sdΔ87.Scer\UAS in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes sdΔ88-123.Scer\UAS in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes sdΔ88-159.Scer\UAS in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes sdΔ96.Scer\UAS in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)BSC629 (Christensen et al., 2008.9.29) Df(1)BSC707 (Christensen et al., 2008.12.28) Df(1)BSC714 (Christensen et al., 2008.12.28) Df(1)BSC756 (Christensen et al., 2009.5.6) Df(1)BSC757 (Christensen et al., 2009.2.28) Df(1)EM43 (Katzen, 1990) Df(1)Exel6251 (Ryder, 2004.4.26) Df(1)sd72b (Katzen, 1990, Katzen and Bishop, 1996) Df(1)sdΔC (Zhang et al., 2008) In(1)sd2 (Panshin, 1935)
Partially disrupted in	Df(1)sdΔC (Zhang et al., 2008)
Duplicated in	Dp(1;4)r+l (Katzen, 1990) Dp(1;Y)shi+1 (Poodry, 1980, Katzen, 1990, Katzen and Bishop, 1996) Dp(1;Y)shi+2 (Poodry, 1980, Poodry, 1980) Dp(1;Y)shi+3 (Poodry, 1980)
Not disrupted in	Df(1)19 (Katzen, 1990, Katzen and Bishop, 1996) Df(1)354 (Patterson, 1932) Dp(1;4)r+m (Katzen and Bishop, 1996) Dp(1;4)r+s (Katzen and Bishop, 1996) In(1)AC2LABR (Roote, 1997.4.9)
Not duplicated in	Dp(1;3)v+74c (Schalet, 1986) Dp(1;4)r+l (Schalet, 1986) Dp(1;4)r+m (Katzen, 1990) Dp(1;4)r+s (Katzen, 1990) Dp(1;Y)BSsog+y+ (Wickline and Lindsley, 1997)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4744} NA P{KK108877} NA P{NIG.8544R} NA P{TRiP.GL00410} NA P{TRiP.JF02514} NA P{UAS-sd.3xFLAG} NA P{UAS-sd.GA} NA P{UAS-sd.HA} NA P{UAS-sd.RNAi.C} NA P{UAS-sd.RNAi.N} NA P{UAS-sd.S} NA P{UAS-sd.V} NA P{UAS-sd.Δ87} NA P{UAS-sd.Δ88-123} NA P{UAS-sd.Δ88-159} NA P{UAS-sd.Δ96} NA P{UAS-sd.Δ124-159} NA P{UAS-sd.Δ160-219} NA P{UAS-sd.Δ200} NA P{UAS-sd.Δ220-281} NA P{UAS-sd.Δ220-344} NA P{UAS-sd.Δ282-344} NA GAL4 construct P{hs-sd.T:Scer\GAL4} No P{sd-GAL4.U} No P{UAS-sd.GA} No heat-shock construct P{hs-sd.C} NA P{hs-sd.T:Scer\GAL4} NA characterization construct P{ry1-547} NA P{UAS-vg::sd.TEA} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}sdEP1088 NA P{EP}sdEP1188 NA P{EP}sdEP1435 NA P{EPgy2}sdEY10259 NA P{GSV1}C373C373 NA P{Mae-UAS.6.11}B2022B2022 NA P{Mae-UAS.6.11}B2023B2023 NA P{Mae-UAS.6.11}sdGG01029 NA P{Mae-UAS.6.11}sdGG01101 NA P{Mae-UAS.6.11}sdGG01829 NA P{XP}sdd01505 NA P{XP}sdd04263 NA P{XP}sdd09376 NA PBac{RB5.WH5}sdΔB NA miscellaneous insertions P{3'ry1}sd+175ba NA P{3'ry1}sd+175bb NA P{3'ry1}sd+231ba NA P{3'ry1}sd+231bb NA P{3'ry1}sd+292b NA P{3'ry1-Δ57}sdR-57 NA P{3'ry1-Δ58}sdR-58 NA P{3'ry1-Δ69}sdR-69 NA P{3'ry1-Δ111}sdR-111 NA P{3'ry1-Δ119}sdR-119 NA P{5'ry1-Δ7}sdR-7 NA P{?'hswa.M3}sdM3 NA P{?'hswa.M27}sdM27 NA P{?'hswa.M28}sdM28 NA P{?ry1}sd4 NA P{?ry1}sd5 NA P{?ry1}sd6 NA P{?ry1}sd7 NA P{?ry1}sd8 NA P{GalW}sdS278 NA P{GT1}BG01540BG01540 NA P{GT1}sdBG02605 NA P{hswa}sdwa NA P{hswa-ΔM1.A}sdM1.A NA P{hswa-ΔM2}sdM2 NA P{hswa-ΔM19}sdM19 NA P{hswa-ΔM20}sdM20 NA P{hswa-ΔM21}sdM21 NA P{hswa-ΔM26}sdM26 NA P{hswa-ΔWT1}sdWT1 NA P{hswa-ΔWT2}sdWT2 NA P{hswa-ΔWT3}sdWT3 NA P{hswa-ΔWT8}sdWT8 NA P{hswa-ΔWT9}sdWT9 NA P{hswa-ΔWT10}sdWT10 NA P{hswa-ΔWT11}sdWT11 NA P{hswa-ΔWT12}sdWT12 NA P{hswa-ΔWT13}sdWT13 NA P{PTT-GA}sdCA07575 NA P{RS3}sdCB-0135-3 NA P{RS3}sdCB-5372-3 NA P{RS3}sdCB-5790-3 NA P{RS3}sdCB-6764-3 NA P{RS3}sdCB-6939-3 NA P{RS5}sd5-HA-1903 NA P{RS5}sd5-HA-2741 NA P{ry1-547}sdry2216-547 NA P{ry1-853}sdry2216-853 NA P{ry1}sd48b NA P{ry1}sd91a NA P{ry1}sd109a NA P{ry1}sd194b NA P{ry1}sd215a NA P{ry1}sd232b NA P{ry1}sd330a NA P{ry1}sd+91b NA P{ry1}sd+109b NA P{ry1}sd+175a NA P{ry1}sd+267b NA P{ry1}sd+311b NA P{ry1}sd+422b NA P{ry1}sdry+ NA P{ry1-sd.358}sd358b NA P{ry1-sd.358}sd+358a NA P{ry1-Δ11}sdR-11 NA P{ry1-Δ12}sdR-12 NA P{ry1-Δ14}sdR-14 NA P{ry1-Δ15}sdR-15 NA P{ry1-Δ49}sdR-49 NA P{ry1-Δ50}sdR-50 NA P{ry1-Δ58a}sd58a NA P{ry1-Δ58ab}sd+58ba NA P{ry1-Δ58b}sd+58bb NA P{ry1-Δ59}sdR-59 NA P{ry1-Δ68}sdR-68 NA P{ry1-Δ83}sdR-83 NA P{ry1-Δ84}sdR-84 NA P{ry1-Δ95}sdR-95 NA P{ry1-Δ96}sdR-96 NA P{ry1-Δ99}sdR-99 NA P{ry1-Δ103b}sd103b NA P{ry1-Δ106}sdR-106 NA P{ry1-Δ107}sdR-107 NA P{ry1-Δ113}sdR-113 NA P{ry1-Δ115}sdR-115 NA P{ry1-Δ115a}sd115a NA P{ry1-Δ117}sdR-117 NA P{ry1-Δ118}sdR-118 NA P{ry1-Δ215b}sd+215b NA P{ry1-Δ231a}sd+231aa NA P{ry1-Δ231a}sd+231ab NA P{ry1-Δ232a}sd232a NA P{ry1-Δ239b}sd+239b NA P{ry1-Δ253b}sd+253b NA P{ry1-Δ263b}sd+263b NA P{ry1-Δ267a}sd267a NA P{ry1-Δ311a}sd311a NA P{ry1-Δ330b}sd330b NA P{ry1-Δ338b}sd338b NA P{ry1-Δ409b}sd409b NA P{ry1-Δ422a}sd+422a NA P{SUPor-P}sdKG04449 NA P{UAS-lacZ.Abd-B.5F3}sdCMM1 NA P{UAS-lacZ.Abd-B.5F24}25,2a NA P{UAS-lacZ.Abd-B.5F24}25,2b NA P{UAS-lacZ.Abd-B.5F24}sdCMM2 NA P{wE}sdE3 NA PBac{RB}sde00587 NA PBac{RB}sde02321 NA PBac{RB}sde04539 NA PBac{WH}sdf04046 NA PBac{WH}sdf04484 NA PBac{WH}sdf06088 NA PBac{WH}sdf06474 NA insertion of enhancer trap binary system P{GawB}sdNP0274 No P{GawB}sdNP0654 No P{GawB}sdNP0759 No P{GawB}sdNP0790 No P{GawB}sdNP0975 No P{GawB}sdNP1035 No P{GawB}sdNP1090 No P{GawB}sdNP1521 No P{GawB}sdNP2014 No P{GawB}sdNP2542 No P{GawB}sdNP4066 No P{GawB}sdNP5124 No P{GawB}sdNP7148 No P{GawB}sdNP7192 No P{GawB}sdNP7222 No P{GawB}sdNP7228 No P{GawB}sdSG29.1 No insertion of enhancer trap P{lacW}sdG0239 No P{lacW}sdG0262 No P{lacW}sdG0300 No P{lacW}sdG0309 No P{lacW}sdG0315b No P{lacW}sdG0483 No P{lacZ-un1}sd3 No P{lacZ-un1}sd14 No P{lacZ-un1}sd15 No P{lArB}sdETX4 No P{lArB}sdETX81a No P{lArB}sdETX81b No
Gene Ontology: Function, Process & Cellular Component ( 19 unique terms )
Terms Based on Experimental Evidence ( 15 terms )
Molecular Function
CV term Evidence References
protein domain specific binding inferred from physical interaction with UniProtKB:Q26366 (assigned by UniProtKB) (Simmonds et al., 1998) RNA polymerase II distal enhancer sequence-specific DNA binding inferred from direct assay (Halder et al., 1998) contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity inferred from direct assay (Halder et al., 1998) transcription factor binding inferred from physical interaction with yki (Goulev et al., 2008) transcription regulatory region DNA binding inferred from direct assay (Wu et al., 2008)
Biological Process
CV term Evidence References
cardiac muscle cell development inferred from mutant phenotype (Deng et al., 2009) compound eye morphogenesis inferred from mutant phenotype (Garg et al., 2007) imaginal disc-derived leg morphogenesis inferred from mutant phenotype (Garg et al., 2007) imaginal disc-derived wing morphogenesis inferred from direct assay (assigned by UniProtKB) (Simmonds et al., 1998) inferred from mutant phenotype (Dworkin and Gibson, 2006, Carreira et al., 2011) positive regulation of transcription from RNA polymerase II promoter inferred from genetic interaction with vg (Halder et al., 1998) inferred from mutant phenotype (Halder et al., 1998) sensory organ development inferred from mutant phenotype (Srivastava and Bell, 2003) somatic muscle development inferred from mutant phenotype (Deng et al., 2009) stem cell proliferation inferred from direct assay (Ren et al., 2010) wing disc development inferred from genetic interaction with vg (Halder et al., 1998)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (Goulev et al., 2008) inferred from direct assay (assigned by UniProtKB) (Simmonds et al., 1998)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
sequence-specific DNA binding transcription factor activity inferred from sequence or structural similarity with UniProtKB:P28347 (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 1993.4.1)
Biological Process
CV term Evidence References
hippo signaling cascade inferred from electronic annotation with InterPro:IPR016361 (FlyBase Curators et al., 2004-) imaginal disc-derived wing morphogenesis traceable author statement (Curtiss et al., 2002) nervous system development non-traceable author statement (Swiss-Prot Project Members, 1993.4.1) regulation of transcription from RNA polymerase II promoter inferred from sequence or structural similarity with UniProtKB:P28347 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
nucleus inferred from sequence or structural similarity with UniProtKB:P28347 (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 1993.4.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions sd allele Gene References sd1 vg (Paumard-Rigal et al., 1998) sd58d sens (Srivastava and Bell, 2003) vg (Simmonds et al., 1998, Chow et al., 2004) wg (Srivastava and Bell, 2003) sdEP1088 pnr (Pena-Rangel et al., 2002) sdEP1435 pnr (Pena-Rangel et al., 2002) sdETX4 sens (Srivastava and Bell, 2003) vg (Paumard-Rigal et al., 1998, Chow et al., 2004) wg (Srivastava and Bell, 2003) sdFab-X trx (Bantignies et al., 2003) sdg6 ct (Morcillo et al., 1996) sdScer\UAS.cSa vg (Simmonds et al., 1998, Chow et al., 2004) sdSG29.1 N (Shyamala and Chopra, 1999) Ser (Shyamala and Chopra, 1999) sdunspecified bi (Bridges and Brehme, 1944) sdΔ200.Scer\UAS vg (Chow et al., 2004) unspecified ct (Jack and DeLotto, 1992) E(sd)   H (Mueller et al., 2005) N (Hing et al., 1999) rho (Sturtevant and Bier, 1995) su(Hw) (Morcillo et al., 1996) vg (Legent et al., 2006, Garg et al., 2007, Silber et al., 1995)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58884 DroID - A comprehensive database of gene and protein interactions. • FBgn0003345 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32536
Orthologs
OrthoDB Orthologs (54) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6ZGPZ3 Dipteran inclusive ortholog search EOG6J9N7C Insect inclusive ortholog search EOG6F1VZH Arthropod inclusive ortholog search EOG693207 Metazoa inclusive ortholog search EOG6M0SVB
Orthologs in Drosophila Species (EOG6ZGPZ3)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\sd     Drosophila sechellia   Dsec\GM22588 Y   Drosophila erecta   Dere\GG17919 Y   Drosophila ananassae   Dana\GF10606 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA21152 Y   Drosophila persimilis   Dper\GL22923 Y   Drosophila willistoni   Dwil\GK25682 Y   Drosophila virilis   Dvir\GJ19539 Y   Drosophila mojavensis   Dmoj\GI14876 Y   Drosophila grimshawi   Dgri\GH10841
Orthologs in non-Drosophila Dipterans (EOG6J9N7C)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL014670   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL015035   Anopheles gambiae Malaria mosquito  Agam\AGAP000512   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ013490
Orthologs in non-Dipteran Insects (EOG6F1VZH)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\sd   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG012495   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH10333   Atta cephalotes Leafcutter ant  Acep\ACEP20936   Camponotus floridanus Florida carpenter ant  Cflo\CFLO15135   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL16140   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL16139   Linepithema humile Argentine ant  Lhum\LH26238   Pogonomyrmex barbatus Red harvester ant  Pbar\PB27252   Solenopsis invicta Red fire ant  Sinv\SINV25010   Acyrthosiphon pisum Pea aphid  Apim\ACYPI001652   Bombyx mori Silkmoth  Bmor\BGIBMGA001129   Pediculus humanus Human body louse  Phum\PHUM251000   Tribolium castaneum Red flour beetle  Tcas\TC030781
Orthologs in non-Insect Arthropods (EOG693207)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\COI   Daphnia pulex Water flea  Dpux\COI   Ixodes scapularis Deer tick  Isca\ISCW001055
Orthologs in non-Arthropod Metazoa (EOG6M0SVB)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\egl-44   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_021210gn   Danio rerio Zebrafish  Drer\tead3a   Danio rerio Zebrafish  Drer\ENSDARG00000087397   Danio rerio Zebrafish  Drer\tead1b   Danio rerio Zebrafish  Drer\tead1a   Danio rerio Zebrafish  Drer\zgc:171784   Danio rerio Zebrafish  Drer\CABZ01090021.1   Xenopus tropicalis Western clawed frog  Xtro\tead4   Gallus gallus Domestic chicken  Ggal\TEAD4   Gallus gallus Domestic chicken  Ggal\ENSGALG00000000953   Gallus gallus Domestic chicken  Ggal\TEAD1   Mus musculus House mouse  Mmus\Tead2   Mus musculus House mouse  Mmus\Tead1   Mus musculus House mouse  Mmus\Tead3   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000005608   Rattus norvegicus Norway rat  Rnor\Tead1   Rattus norvegicus Norway rat  Rnor\Tead2   Rattus norvegicus Norway rat  Rnor\Tead3   Homo sapiens Human  Hsap\TEAD2   Homo sapiens Human  Hsap\ENSG00000197905   Homo sapiens Human  Hsap\ENSG00000007866   Homo sapiens Human  Hsap\ENSG00000187079
Human Orthologs (4)
Gene OMIM HGNC Hsap\TEAD2     Hsap\ENSG00000197905     Hsap\ENSG00000007866     Hsap\ENSG00000187079
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD24822 Drosophila sechellia Dsec\GM22588 Drosophila erecta Dere\GG17919 Drosophila yakuba Dyak\GE17227 Drosophila ananassae Dana\GF10606 Drosophila pseudoobscura pseudoobscura Dpse\GA21152 Drosophila persimilis Dper\GL22923 Drosophila willistoni Dwil\GK25682 Drosophila virilis Dvir\GJ19539 Drosophila mojavensis Dmoj\GI14876 Drosophila grimshawi Dgri\GH12522
Stocks & Reagents
Stocks Listed in FlyBase ( 74 )
Bloomington	1027 sd1 9373 w*; P{UAS-sd.S}V1
Harvard	- P{XP}sdd01505 - P{XP}sdd04263 - PBac{RB}sde00587 - PBac{RB}sde02321 - PBac{RB}sde04539 - PBac{WH}sdf04046 - PBac{WH}sdf04484 - PBac{WH}sdf06474
Kyoto	106174 sd1
VDRC	v101497 P{KK108877}VIE-260B
	More stocks available...
Genomic Clones ( 2 )
	BACR22H11 BACR25C18 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 90 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP16090 RE23308 RE25404
Other clones	FI18101 IP16390
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT02767 GM08868 LD02619 RE23135 RE35685 RE70080 RH50062 SD15070
Other clones	893 10137 17508 18205 28974 30935 42086 47321 58186 67597 97574 98278 102826 106221 108209 144588 146481 147627 153019 156258 163006 164588 164750 190216 192143 192245 210982 272507 473495 473576 527154 CK01.40A.F8 CK01.168D.F11 Dmel_dig_019950_0674_3336 Dmel_neb_010076_0885_0993 EK105804 EK107409 EK107807 EK110054 EK155505 EK169825 EK174114 EK175423 EK195712 EK206903 EK220814 EK232023 EK234743 EK242637 EK244251 EK249227 EK250847 EK256231 EK259149 EK267338 EK269262 EK290129 EK290248 EK292224 EK294953 EK295227 EN00159 EN00259 EN07353 EP15142 FGM235C10 IP16290 RP003676404 RP004219296 RP004384872 RP004474845 RP004479211 RP004485691 RP004502226 RP004528726 SD07871 SD08135
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0003345 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32536
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: sd CG8544 (Wang, 1999.11)
Source for database merge of	Source for merge of: sd anon-EST:Liang-2.14 (Ashburner, 2004.6.30) Source for merge of: sd EP1088 (Bidet et al., 2003) Source for merge of: sd l(1)G0239 l(1)G0262 l(1)G0309 l(1)G0483 (Peter et al., 2002)
Additional comments	Hsap\TCF13 can substitute for sd function. (Deshpande, 1998)
Other Comments
	It appears that sd must be functional for proper sens expression, and ultimately for sensory organ precursor development. (Srivastava and Bell, 2003) Binding of vg protein to sd protein switches the DNA-binding selectivity of sd. (Halder and Carroll, 2001) sd and vg-dependant cell adhesion may contribute to separation of the wing blade from the wing hinge and to a gradient of cell affinities along the dorsal-ventral axis of the wing. (Liu et al., 2000) Specific interactions between vg and sd are required to promote wing tissue proliferation. (Paumard-Rigal et al., 1998) vg and sd function coordinately to control the expression of genes required for wing development. (Simmonds et al., 1998) Targeted expression of sd does not induced proliferation in imaginal discs, wing outgrowths in adult tissues or vg expression. Thus sd plays a subordinate role to vg in wing development. (Kim et al., 1996) sd, mam and Chi cooperate synergistically to regulate ct expression. (Morcillo et al., 1996) vg is required for the proper pattern of expression of ap, sd and Ser. (Silber et al., 1995) The wg product is required to restrict the expression of the apterous gene to dorsal cells in the developing wing and to promote the expression of the vestigial and scalloped genes that demarcate the wing primordia and are required for the development of the wing proper. The pro-wing vg and sd genes regulate each other. (Williams et al., 1993) Expression of an sd enhancer trap line suggests that sd gene product participates in a regulatory network controlling the differentiation of the nervous system. (Campbell et al., 1992) sd is essential for normal development. Mutation analysis suggests that sd might be haploinsufficient for both the wing margin and ectopic bristle traits. (Campbell et al., 1991)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078614 NM_167465 NM_206727 NM_001103519 NM_001103520 NM_001103521 NM_001103522 NM_001169290 NM_001169291 NM_001258767 NM_001258768 NM_001258769 NM_001258770 NM_001258771 NM_001258772 NM_001258773 NM_001272652 NM_001272653 NM_001272654 RefSeq (Proteins) • NP_511169 NP_727900 NP_996450 NP_001096989 NP_001096990 NP_001096991 NP_001096992 NP_001162761 NP_001162762 NP_001245696 NP_001245697 NP_001245698 NP_001245699 NP_001245700 NP_001245701 NP_001245702 NP_001259581 NP_001259582 NP_001259583 DDBJ / EMBL / GenBank • AAA28881 AAF48521 AAL48803 AAN09366 AAS65351 ABW09420 ABW09421 ABW09422 ABW09423 ACZ95296 ACZ95297 AFH07409 AFH07410 AFH07411 AFH07412 AFH07413 AFH07414 AFH07415 AGB95423 AGB95424 AGB95425 AI124301 AJ426940 AJ426941 AJ426943 AJ426945 AQ025381 AQ025462 AY071181 AY863462 AY863463 AY863464 AY863465 AY863466 AY863467 AY863468 AY863469 AY863470 AY863471 AY863472 AY863473 AY863474 AY863475 AY863476 AY863477 AY863478 AY863479 AY863480 AY863481 BI231690 CZ473820 CZ476708 CZ480145 CZ486626 CZ487021 CZ488730 CZ488731 CZ489177 CZ489178 DQ327770 L07659 L07660 L07661 L07662 L07663 M83787 Z32346 Entrez Gene - A searchable database of RefSeq genes. • 32536 UniProtKB/Swiss-Prot • P30052 UniProtKB/TrEMBL • A8JUY5 A8JUY9 E1JJ99 Q8IR25 Q8SZ20
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • TEA/ATTS (IPR000818) Transcriptional enhancer factor (IPR016361) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RE23308
Linkouts
	BioGRID - A database of protein and genetic interactions • 58884 DroID - A comprehensive database of gene and protein interactions. • FBgn0003345 DRSC - Results from RNAi screens. • FBgn0003345 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003345 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8544-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0003345 FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways • 101208 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32536 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /gene/scallopd.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32536 modMine - Data generated by the modENCODE project. • FBgn0003345 REDfly - A database of transcriptional regulatory elements. • FBgn0003345
Synonyms & Secondary IDs ( 22 )
Reported As
Symbol Synonym	anon-EST:Liang-2.14   CG8544 (Ashburner, 2004.6.30, Norga et al., 2003, Mount, 2001.8.14, Hadar et al., 2012, Molnar et al., 2006, Grieder et al., 2007, Keleman et al., 2009.8.5, Perkins et al., 2009, Ni et al., 2011.7.19) clone 2.14 (Liang and Biggin, 1998) DROEXO (Schug et al., 1998) DROEXO2 (Schug et al., 1997) EP1088   EP(X)1088 (Pena-Rangel et al., 2002) l(1)G0239 (Schaefer et al., 1999.6.15, ) l(1)G0262 (Schaefer et al., 1999.6.15, ) l(1)G0309 (Schaefer et al., 1999.6.15, ) l(1)G0315   l(1)G0483 (Schaefer et al., 1999.12.2, ) l(1)HF394   l(1)III   sd (Dworkin and Gibson., 2006, Grimaud et al., 2006, Dworkin and Gibson, 2006, Delanoue et al., 2002, Legent et al., 2006, Aerts et al., 2007, Ayyub et al., 2005, Delanoue et al., 2004, Buszczak et al., 2007, Kavi et al., 2006, Garg et al., 2007, Tussey et al., 2008, Molnar et al., 2006, Grieder et al., 2007, Blumenthal, 2008, Christensen et al., 2008.9.29, Macdonald and Long, 2005, Grimberg et al., 2011, González et al., 2009, Zhang et al., 2011, Magico and Bell, 2011, Pastor-Pareja and Xu, 2011, Takemura and Adachi-Yamada, 2011, Fedorova et al., 2008, Oh and Irvine, 2011, Christensen et al., 2008.12.28, Zhang et al., 2008, Wu et al., 2008, Goulev et al., 2008, Ray et al., 2008, Christensen et al., 2009.2.28, Zhao et al., 2008, Deng et al., 2009, Ayroles et al., 2009, Christensen et al., 2009.5.6, Angulo et al., 2004, Dworkin et al., 2009, Carreira et al., 2009, Bernard et al., 2009, Zhang et al., 2008, Manak et al., 2006, Otsuna and Ito, 2006, Robinson et al., 2010, Chan et al., 2010, Reddy et al., 2010, Ziosi et al., 2010, Neto-Silva et al., 2010, Lawrence et al., 2000, Yatsu et al., 2008, Beltran et al., 2007, Ren et al., 2010, Dworkin et al., 2011, Deng et al., 2010, Marygold et al., 2011, Bejarano et al., 2012, Reddy and Irvine, 2011, Carreira et al., 2011, Schönbauer et al., 2011, Japanese National Institute of Genetics, 2012.5.21) Sd (Mann and Carroll, 2002, Takanaka and Courey, 2005, Zhang et al., 2011, Dutta and Baehrecke, 2008, Oh and Irvine, 2009, Zhang et al., 2009, Magalhaes et al., 2007, Ren et al., 2010, Ribeiro et al., 2010, Jin et al., 2012) SD (Garg et al., 2007, Garg and Bell, 2010) sp (Valencia, 1959, ) TEAD (Oh and Irvine, 2009)
Name Synonym	Scalloped (Richter et al., 2011, Garg et al., 2007, Takanaka and Courey, 2005, Pastor-Pareja and Xu, 2011, Zhang et al., 2008, Wu et al., 2008, Dutta and Baehrecke, 2008, Ren et al., 2010, Ribeiro et al., 2010, Reddy et al., 2010, Neto-Silva et al., 2010, Garg and Bell, 2010) scalloped (Campbell, 1992.5.28, Dworkin and Gibson, 2006, Legent et al., 2006, Ayyub et al., 2005, Hadar et al., 2012, Delanoue et al., 2004, Poodry, 1980, Kavi et al., 2006, Tussey et al., 2008, Li and Baker, 2007, Blumenthal, 2008, Takemura and Adachi-Yamada, 2011, Seppa et al., 2008, Goulev et al., 2008, Ray et al., 2008, Deng et al., 2009, Dworkin et al., 2009, Carreira et al., 2009, Magalhaes et al., 2007, Robinson et al., 2010, Chan et al., 2010, Lawrence et al., 2000, Marygold et al., 2011, Schönbauer et al., 2011) spatula (Valencia, 1959, )
Secondary FlyBase IDs
	FBgn0025967 FBgn0026840 FBgn0027221 FBgn0027225 FBgn0027247 FBgn0027258 FBgn0040146 FBgn0062702
References ( 273 )
Generate a list of	All references relating to this gene ( 273 )
List References by type	Research paper  ( 167 ) Supplementary material  ( 9 ) Review  ( 27 ) Personal communication to FlyBase  ( 24 ) Abstract  ( 31 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Stock list  ( 1 ) Curated genome annotation  ( 3 ) Protein sequence record  ( 1 ) Website  ( 1 ) Thesis  ( 2 ) Book  ( 2 ) Letter  ( 1 )
Recent research papers ( 24 )
	Singh et al., 2013, Genetics 193(1): 215--228 Inferences of Demography and Selection in an African Population of Drosophila melanogaster. [FBrf0220398] Bayarmagnai et al., 2012, Cell Cycle 11(22): 4191--4202 Drosophila GAGA factor is required for full activation of the dE2f1-Yki/Sd transcriptional program. [FBrf0220001] Bejarano et al., 2012, Development 139(15): 2821--2831 A genome-wide transgenic resource for conditional expression of Drosophila microRNAs. [FBrf0218840] Hadar et al., 2012, Gene 494(1): 65--72 A screen identifying genes responsive to Dpp and Wg signaling in the Drosophila developing wing. [FBrf0217293] Jin et al., 2012, J. Biol. Chem. 287(8): 5784--5796 Dimerization and cytoplasmic localization regulate Hippo kinase signaling activity in organ size control. [FBrf0217990] Sebé-Pedrós et al., 2012, Cell Rep. 1(1): 13--20 Premetazoan origin of the hippo signaling pathway. [FBrf0219051] Verghese et al., 2012, PLoS ONE 7(11): e47173 Scribble acts in the Drosophila fat-hippo pathway to regulate warts activity. [FBrf0219901] Wandler and Guillemin, 2012, PLoS Pathog. 8(10): e1002939 Transgenic Expression of the Helicobacter pylori Virulence Factor CagA Promotes Apoptosis or Tumorigenesis through JNK Activation in Drosophila. [FBrf0219744] Carreira et al., 2011, BMC Dev. Biol. 11: 32 Genetic basis of wing morphogenesis in Drosophila: sexual dimorphism and non-allometric effects of shape variation. [FBrf0214273] Doggett et al., 2011, BMC Dev. Biol. 11: 57 Loss of the Drosophila cell polarity regulator Scribbled promotes epithelial tissue overgrowth and cooperation with oncogenic Ras-Raf through impaired Hippo pathway signaling. [FBrf0216618] Dworkin et al., 2011, Genetics 187(4): 1171--1184 The effects of weak genetic perturbations on the transcriptome of the wing imaginal disc and its association with wing shape in Drosophila melanogaster. [FBrf0214376] Grimberg et al., 2011, Mol. Cell. Biol. 31(4): 897--909 Basic Leucine Zipper Protein Cnc-C Is a Substrate and Transcriptional Regulator of the Drosophila 26S Proteasome. [FBrf0212906] Magico and Bell, 2011, PLoS ONE 6(6): e21431 Identification of a Classical Bipartite Nuclear Localization Signal in the Drosophila TEA/ATTS Protein Scalloped. [FBrf0214267] Marygold et al., 2011, Fly 5(4): 291--303 Genetic characterization of ebi reveals its critical role in Drosophila wing growth. [FBrf0216882] Nicolay et al., 2011, Genes Dev. 25(4): 323--335 Cooperation between dE2F1 and Yki/Sd defines a distinct transcriptional program necessary to bypass cell cycle exit. [FBrf0214348] Oh and Irvine, 2011, Dev. Cell 20(1): 109--122 Cooperative Regulation of Growth by Yorkie and Mad through bantam. [FBrf0212763] Pastor-Pareja and Xu, 2011, Dev. Cell 21(2): 245--256 Shaping Cells and Organs in Drosophila by Opposing Roles of Fat Body-Secreted Collagen IV and Perlecan. [FBrf0214668] Poon et al., 2011, Dev. Cell 21(5): 896--906 The Sterile 20-like Kinase Tao-1 Controls Tissue Growth by Regulating the Salvador-Warts-Hippo Pathway. [FBrf0216620] Reddy and Irvine, 2011, Development 138(23): 5201--5212 Regulation of Drosophila glial cell proliferation by Merlin-Hippo signaling. [FBrf0216584] Richter et al., 2011, Nat. Cell Biol. 13(9): 1029--1039 The tumour suppressor L(3)mbt inhibits neuroepithelial proliferation and acts on insulator elements. [FBrf0215050] Schönbauer et al., 2011, Nature 479(7373): 406--409 Spalt mediates an evolutionarily conserved switch to fibrillar muscle fate in insects. [FBrf0216735] Takemura and Adachi-Yamada, 2011, Dev. Biol. 357(2): 336--346 Cell death and selective adhesion reorganize the dorsoventral boundary for zigzag patterning of Drosophila wing margin hairs. [FBrf0214791] Zhang et al., 2011, Cell Death Differ. 18(8): 1346--1355 Wbp2 cooperates with Yorkie to drive tissue growth downstream of the Salvador-Warts-Hippo pathway. [FBrf0214266] Zhang et al., 2011, PLoS ONE 6(7): e22278 Yki/YAP, Sd/TEAD and Hth/MEIS Control Tissue Specification in the Drosophila Eye Disc Epithelium. [FBrf0214606] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...