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Gene Dmel\RanGAP

General Information
Symbol	Dmel\RanGAP	Species	D. melanogaster
Name	Ran GTPase activating protein	Annotation symbol	CG9999
Feature type	protein_coding_gene	FlyBase ID	FBgn0003346
Gene Model Status	Current	Stock availability	12 publicly available
Also Known As	Sd, rangap, Sd-RanGAP
Genomic Location
Chromosome (arm)	2L	Recombination map	2-54
Cytogenetic map	37E1-37E1	Sequence location	2L:19,441,959..19,447,317 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Ran GTPase activating protein is referred to in FlyBase by the symbol Dmel\RanGAP (CG9999, FBgn0003346). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: Ran GTPase activator activity. There is experimental evidence that it is involved in the biological process: neurogenesis. 31 alleles are reported. The phenotypes of these alleles are annotated with: spermatid; mesothoracic tergum. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Ran GTPase-activating protein. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult hindgut, larval fat body, larval salivary gland, larval trachea, adult male reproductive system, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1623819_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of RanGap. Gene sequence location is 2L:19441959..19447317.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	Sd: Segregation distorter Sd-bearing second chromosomes are referred to as SD; they carry, in addition to Sd, other components of the segregation distortion system; they may carry inversions and recessive lethal alleles as well. The constitutions of various SD chromosomes are tabulated below. Other components of the segregation distortion system are E(SD) (Enhancer of SD) at the base of 2L; and Rsp (Responder) at the base of 2R; St(SD) (Stabilizer of SD) located more distally in 2R appears to comprise several weak enhancers of distortion (Miklos, 1972, Genetics 70: 405-18). All naturally occurring SD chromosomes carry Sd and E(SD) but lack Rsp [sometimes said to carry Rspi (Responder insensitive)]; most normal chromosomes carry a Rsp element. SD/+ males transmit SD-bearing, to the virtual exclusion of +-bearing, homologues; as many as 99% of the functional sperm may carry SD (defined as k = .99). The sex ratio of the minority class of offspring, in diverse crosses, is skewed in proportion to k in such a way as to indicate that within this class the probability of recovery of XY- < X - < Y -bearing <nullo-X, nullo-Y sperm (Denell, Judd, and Richardson, 1969, Genetics 61: 129-39; Denell and Miklos, 1971, Mol. Gen. Genet. 110: 167-77). Distortion by Sd requires heterozygosity at the Rsp locus; when Rsp is on the homologue, the Sd-bearing chromosome is preferentially recovered. and when Rsp and Sd are in coupling, the homologue is recovered preferentially. Extensive electron microscopic studies of spermatogenesis (Tokuyasu, Peacock, and Hardy, 1972, Z. Zellforsch. 124: 479-506; 127: 492-525; 1977, J. Ultrastruct. Res. 48: 284-303) demonstrate that spermiogenesis of SD/+ males is defective; chromatin in half of the spermatid nuclei fails to condense properly, leading in some cases to a failure of the spermatids to become individually invested in membrane, remaining syncytial instead, and in all cases to incomplete maturation of half the sperm. In addition, the transition from lysine-rich to sperm-specific arginine-rich histone, which normally occurs in late spermiogenesis, does not appear to take place in half the spermatids of SD/+ males (Hauschteck-Jungen and Hartl, 1978, Genetics 101: 57-69). Temperature-sensitive period of distortion said to be in the primary spermatocyte (Mange, 1968, Genetics 58: 399-413); however, see Matthews and Mortin (1983, Canad. J. Genet. Cytol. 25: 662-67). k values also reported to increase with time of storage of sperm by females (Hartl, 1973, Genetics 74: 619-31), to decrease with the age of SD/+ males (Hiraizumi and Watanabe, 1969, Genetics 63: 212-31), and to be influenced by the genotype of the female to which such males are crossed (Denell and Judd, 1969, Mol. Gen. Genet. 105: 262-74). Segregation distortion is subject to modification by numerous genetic factors throughout the genome; in addition various abnormal chromosome constitutions have been reported to reduce k values (Novitski and Erlich, 1970, DIS 45: 102; Enns, 1970, DIS 45: 136; Fowler, 1971, DIS 46: 74). Homozygous (when viable) and heteroallelic constitutions exhibit variably reduced male fertility, but the contribution of Sd vis a vis other components of the SD chromosomes involved not easily ascertainable. SD chromosomes without effect in females.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 37E1-37E1   Limits computationally determined from genome sequence between P{EP}dntEP2158 and P{EP}EP623&P{PZ}spi01068
Experimentally Determined Cytological Location
Cytogenetic map Notes References 37D2-37D5     (Merrill, 1999.4.16) 37D3-37D5   (determined by in situ hybridisation)   (Powers and Ganetzky, 1991)
Experimentally Determined Recombination Data
Location	2-54
Left of (cM)	pr
Right of (cM)	hk
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\RanGAP for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.47
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) RanGAP-RA FBtr0081234  NM_057364   2401   596 RanGAP-RB FBtr0334174  NM_001273649   2008   596 RanGAP-RC FBtr0334175  NM_001273650   2144   588
Additional Transcript Data & Comments
Reported size (kB)	2.0 (northern blot) (Powers and Ganetzky, 1991)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein RanGAP-PA   FBpp0080775   66.1   596   4.29     NP_476712   AAF53801 RanGAP-PB   FBpp0306291   66.1   596   4.29     NP_001260578   AGB93113 RanGAP-PC   FBpp0306292   65.2   588   4.29     NP_001260579   AGB93114
Additional Polypeptide Data & Comments
Reported size (kDa)	596 (aa); 66 (kD observed) (Merrill et al., 1999) 363 (aa) (Powers and Ganetzky, 1991)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Ran GTPase-activating protein (IPR027038)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202164   AA246228   AA391387   AA391535   AA441427   AA539177   AA540454   AA540727   AA541103   AA696641   AA801930   AA804116   AA942513   AA979505   AA979511   AE014134 AAF53801   AC005428   AC007082   AF143860 AAD31518   AE014134 AGB93113   AE014134 AGB93114   AI295891   AI456141   AI456957   AI515976   AI519270   AI531117   AI546396   AQ025044   AW942414   AX094031   AY061219 AAL28767   BG636704   BG638884   BG640347   BI163254   BI213883   BI227586   BI228432   BI230157   BI243285   BI352850   BI353475   BI355760   BI369168   BI370138   BI375378   BI481655   BI579997   BI580663   BI637266   BP557672   BP557673   CO177388   CO278055   CO282659   CO292782   CO340011   CO341168   CZ471178   CZ471183   CZ471187   EC068444   EC084037   EC086099   EC199603   EC224157   EC230118   EC247365   EC255788   EC258249   EV588143   EV595592
UniProtKB/Swiss-Prot	Q9VIW3
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference adult stage     (Powers and Ganetzky, 1991) in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   anlage in statu nascendi   (Fisher et al., 2012) dorsal ectoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi ectoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi endoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi foregut anlage in statu nascendi   (Fisher et al., 2012) hindgut anlage in statu nascendi   (Fisher et al., 2012) mesectoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi mesoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi organism | ubiquitous   (Fisher et al., 2012) ventral ectoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi visual anlage in statu nascendi   (Fisher et al., 2012) embryonic stage 7 -- 8   antennal anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage central brain anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage dorsal head epidermis anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage visual anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage anterior endoderm anlage   (Fisher et al., 2012) dorsal ectoderm   (Fisher et al., 2012) foregut anlage   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) hindgut anlage   (Fisher et al., 2012) mesectoderm   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral ectoderm   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) Comment:reported as ventral nerve cord anlage embryonic stage 9 -- 10   antennal primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium central brain primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium visual primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium dorsal head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium lateral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium ventral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium anterior endoderm   (Fisher et al., 2012) dorsal ectoderm   (Fisher et al., 2012) foregut primordium   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) inclusive hindgut primordium   (Fisher et al., 2012) mesectoderm   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral ectoderm   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 11 -- 12   central brain primordium   (Fisher et al., 2012) embryonic central brain glial cell   (Fisher et al., 2012) embryonic central brain neuron   (Fisher et al., 2012) embryonic neuroblast of ventral nerve cord primordium   (Fisher et al., 2012) lateral cord glial cell   (Fisher et al., 2012) lateral cord neuron   (Fisher et al., 2012) procephalic neuroblast   (Fisher et al., 2012) proventriculus primordium   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) embryonic central brain glial cell   (Fisher et al., 2012) embryonic central brain neuron   (Fisher et al., 2012) embryonic central brain surface glia   (Fisher et al., 2012) embryonic/larval nervous system   (Fisher et al., 2012) gonad   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012) northern blot Stage Tissue/Position (including subcellular localization) Reference pupal stage     (Powers and Ganetzky, 1991)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage     • nuclear membrane (Trieselmann and Wilde, 2002) larval stage   embryonic/larval salivary gland   • nuclear membrane & cytoplasm (Kusano et al., 2001) adult stage   testis   • nuclear membrane & cytoplasm (Kusano et al., 2001) western blot Stage Tissue/Position (including subcellular localization) Reference adult stage | male   testis   (Merrill et al., 1999)
Additional Descriptive Data
	The protein is localized to the cytoplamic side of the nuclear membrane in both adult testis cells and larval salivary gland cells. (Kusano et al., 2001) The RanGAP protein is detected in Western blots of dissected testes. (Merrill et al., 1999)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult hindgut, larval fat body, larval salivary gland, larval trachea, adult male reproductive system, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    777.4 Larval Midgut    71.3 Larval Hindgut    117.7 Larval Malpighian Tubules    74.3 Larval Fat Body    110.9 Larval Salivary Gland    213.6 Larval Trachea    309.475 Larval Carcass    163.625 Adult Head    63.3 Adult Eye    64.9 Adult Brain    52.2 Adult Thoracic-Abdominal Ganglion    84.1 Adult Crop    78.9 Adult Midgut    73.8 Adult Hindgut    113.8 Adult Malpighian Tubules    60 Adult Fat Body    73.5 Adult Salivary Gland    43.2 Adult Heart    58.45 Adult VirginFemale Spermatheca    79.3 Adult InseminatedFemale Spermatheca    94.1 Adult Ovary    560.2 Adult Testis    222.2 Adult Male Accessory Gland    118.3 Adult Carcass    60.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (777.4) Larval Midgut    71.3 Larval Hindgut    117.7 Larval Malpighian Tubules    74.3 Larval Fat Body    110.9 Larval Salivary Gland    213.6 Larval Trachea    309.475 Larval Carcass    163.625 Adult Head    63.3 Adult Eye    64.9 Adult Brain    52.2 Adult Thoracic-Abdominal Ganglion    84.1 Adult Crop    78.9 Adult Midgut    73.8 Adult Hindgut    113.8 Adult Malpighian Tubules    60 Adult Fat Body    73.5 Adult Salivary Gland    43.2 Adult Heart    58.45 Adult VirginFemale Spermatheca    79.3 Adult InseminatedFemale Spermatheca    94.1 Adult Ovary  (560.2) Adult Testis    222.2 Adult Male Accessory Gland    118.3 Adult Carcass    60.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    777.4 Larval Midgut    71.3 Larval Hindgut    117.7 Larval Malpighian Tubules    74.3 Larval Fat Body    110.9 Larval Salivary Gland    213.6 Larval Trachea    309.475 Larval Carcass    163.625 Adult Head    63.3 Adult Eye    64.9 Adult Brain    52.2 Adult Thoracic-Abdominal Ganglion    84.1 Adult Crop    78.9 Adult Midgut    73.8 Adult Hindgut    113.8 Adult Malpighian Tubules    60 Adult Fat Body    73.5 Adult Salivary Gland    43.2 Adult Heart    58.45 Adult VirginFemale Spermatheca    79.3 Adult InseminatedFemale Spermatheca    94.1 Adult Ovary    560.2 Adult Testis    222.2 Adult Male Accessory Gland    118.3 Adult Carcass    60.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    777.4 Larval Midgut    71.3 Larval Hindgut    117.7 Larval Malpighian Tubules    74.3 Larval Fat Body    110.9 Larval Salivary Gland    213.6 Larval Trachea    309.475 Larval Carcass    163.625 Adult Head    63.3 Adult Eye    64.9 Adult Brain    52.2 Adult Thoracic-Abdominal Ganglion    84.1 Adult Crop    78.9 Adult Midgut    73.8 Adult Hindgut    113.8 Adult Malpighian Tubules    60 Adult Fat Body    73.5 Adult Salivary Gland    43.2 Adult Heart    58.45 Adult VirginFemale Spermatheca    79.3 Adult InseminatedFemale Spermatheca    94.1 Adult Ovary    560.2 Adult Testis    222.2 Adult Male Accessory Gland    118.3 Adult Carcass    60.7 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    777.4 Larval Midgut    71.3 Larval Hindgut    117.7 Larval Malpighian Tubules    74.3 Larval Fat Body    110.9 Larval Salivary Gland    213.6 Larval Trachea    309.475 Larval Carcass    163.625 Adult Head    63.3 Adult Eye    64.9 Adult Brain    52.2 Adult Thoracic-Abdominal Ganglion    84.1 Adult Crop    78.9 Adult Midgut    73.8 Adult Hindgut    113.8 Adult Malpighian Tubules    60 Adult Fat Body    73.5 Adult Salivary Gland    43.2 Adult Heart    58.45 Adult VirginFemale Spermatheca    79.3 Adult InseminatedFemale Spermatheca    94.1 Adult Ovary    560.2 Adult Testis    222.2 Adult Male Accessory Gland    118.3 Adult Carcass    60.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  777.4 Larval Midgut    71.3 Larval Hindgut    117.7 Larval Malpighian Tubules    74.3 Larval Fat Body    110.9 Larval Salivary Gland    213.6 Larval Trachea    309.475 Larval Carcass    163.625 Adult Head    63.3 Adult Eye    64.9 Adult Brain    52.2 Adult Thoracic-Abdominal Ganglion    84.1 Adult Crop    78.9 Adult Midgut    73.8 Adult Hindgut    113.8 Adult Malpighian Tubules    60 Adult Fat Body    73.5 Adult Salivary Gland    43.2 Adult Heart    58.45 Adult VirginFemale Spermatheca    79.3 Adult InseminatedFemale Spermatheca    94.1 Adult Ovary  560.2 Adult Testis    222.2 Adult Male Accessory Gland    118.3 Adult Carcass    60.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    777.4 Larval Midgut    71.3 Larval Hindgut    117.7 Larval Malpighian Tubules    74.3 Larval Fat Body    110.9 Larval Salivary Gland    213.6 Larval Trachea    309.475 Larval Carcass    163.625 Adult Head    63.3 Adult Eye    64.9 Adult Brain    52.2 Adult Thoracic-Abdominal Ganglion    84.1 Adult Crop    78.9 Adult Midgut    73.8 Adult Hindgut    113.8 Adult Malpighian Tubules    60 Adult Fat Body    73.5 Adult Salivary Gland    43.2 Adult Heart    58.45 Adult VirginFemale Spermatheca    79.3 Adult InseminatedFemale Spermatheca    94.1 Adult Ovary    560.2 Adult Testis    222.2 Adult Male Accessory Gland    118.3 Adult Carcass    60.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    777.4 Larval Midgut    71.3 Larval Hindgut    117.7 Larval Malpighian Tubules    74.3 Larval Fat Body    110.9 Larval Salivary Gland    213.6 Larval Trachea    309.475 Larval Carcass    163.625 Adult Head    63.3 Adult Eye    64.9 Adult Brain    52.2 Adult Thoracic-Abdominal Ganglion    84.1 Adult Crop    78.9 Adult Midgut    73.8 Adult Hindgut    113.8 Adult Malpighian Tubules    60 Adult Fat Body    73.5 Adult Salivary Gland    43.2 Adult Heart    58.45 Adult VirginFemale Spermatheca    79.3 Adult InseminatedFemale Spermatheca    94.1 Adult Ovary    560.2 Adult Testis    222.2 Adult Male Accessory Gland    118.3 Adult Carcass    60.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    63.3   NA  Eye    64.9   NA  Brain    52.2   777.4  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    84.1   NA  Crop    78.9   71.3  Midgut    73.8   117.7  Hindgut    113.8   74.3  Malpighian Tubules    60   110.9  Fat Body    73.5   213.6  Salivary Gland    no informative data   NA  Heart    58.45   309.475  Trachea    NA   NA  VirginFemale Spermatheca    79.3   NA  InseminatedFemale Spermatheca    94.1   NA  Ovary    560.2   NA  Testis    222.2   NA  Male Accessory Gland    118.3   163.625  Carcass    60.7 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    56 central nervous system, larvae L3    99 central nervous system, pupae P8    16 head, virgin 1-day female    6 head, virgin 4-day female    8 head, virgin 20-day female    3 head, mated 1-day female    8 head, mated 4-day female    9 head, mated 20-day female    4 head, mated 1-day male    7 head, mated 4-day male    12 head, mated 20-day male    11 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    5 digestive system, 4-day adult    15 digestive system, 20-day adult    9 fat body, larvae L3 wandering    12 fat body, white prepupae    16 fat body, pupae P8    12 carcass, larvae L3 wandering    46 carcass, 1-day adult    9 carcass, 4-day adult    15 carcass, 20-day adult    10 ovary, virgin 4-day female    86 ovary, mated 4-day female    188 testis, mated 4-day male    57 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (56) central nervous system, larvae L3  (99) central nervous system, pupae P8    16 head, virgin 1-day female    6 head, virgin 4-day female    8 head, virgin 20-day female    3 head, mated 1-day female    8 head, mated 4-day female    9 head, mated 20-day female    4 head, mated 1-day male    7 head, mated 4-day male    12 head, mated 20-day male    11 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    5 digestive system, 4-day adult    15 digestive system, 20-day adult    9 fat body, larvae L3 wandering    12 fat body, white prepupae    16 fat body, pupae P8    12 carcass, larvae L3 wandering  (46) carcass, 1-day adult    9 carcass, 4-day adult    15 carcass, 20-day adult    10 ovary, virgin 4-day female  (86) ovary, mated 4-day female  (188) testis, mated 4-day male  (57) accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    56 central nervous system, larvae L3    99 central nervous system, pupae P8    16 head, virgin 1-day female    6 head, virgin 4-day female    8 head, virgin 20-day female    3 head, mated 1-day female    8 head, mated 4-day female    9 head, mated 20-day female    4 head, mated 1-day male    7 head, mated 4-day male    12 head, mated 20-day male    11 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    5 digestive system, 4-day adult    15 digestive system, 20-day adult    9 fat body, larvae L3 wandering    12 fat body, white prepupae    16 fat body, pupae P8    12 carcass, larvae L3 wandering    46 carcass, 1-day adult    9 carcass, 4-day adult    15 carcass, 20-day adult    10 ovary, virgin 4-day female    86 ovary, mated 4-day female  (188) testis, mated 4-day male    57 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    56 central nervous system, larvae L3    99 central nervous system, pupae P8    16 head, virgin 1-day female    6 head, virgin 4-day female    8 head, virgin 20-day female    3 head, mated 1-day female    8 head, mated 4-day female    9 head, mated 20-day female    4 head, mated 1-day male    7 head, mated 4-day male    12 head, mated 20-day male    11 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    5 digestive system, 4-day adult    15 digestive system, 20-day adult    9 fat body, larvae L3 wandering    12 fat body, white prepupae    16 fat body, pupae P8    12 carcass, larvae L3 wandering    46 carcass, 1-day adult    9 carcass, 4-day adult    15 carcass, 20-day adult    10 ovary, virgin 4-day female    86 ovary, mated 4-day female    188 testis, mated 4-day male    57 accessory gland, mated 4-day male    15 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    56 central nervous system, larvae L3    99 central nervous system, pupae P8    16 head, virgin 1-day female    6 head, virgin 4-day female    8 head, virgin 20-day female    3 head, mated 1-day female    8 head, mated 4-day female    9 head, mated 20-day female    4 head, mated 1-day male    7 head, mated 4-day male    12 head, mated 20-day male    11 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    5 digestive system, 4-day adult    15 digestive system, 20-day adult    9 fat body, larvae L3 wandering    12 fat body, white prepupae    16 fat body, pupae P8    12 carcass, larvae L3 wandering    46 carcass, 1-day adult    9 carcass, 4-day adult    15 carcass, 20-day adult    10 ovary, virgin 4-day female    86 ovary, mated 4-day female    188 testis, mated 4-day male    57 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (56) central nervous system, larvae L3  (99) central nervous system, pupae P8    16 head, virgin 1-day female    6 head, virgin 4-day female    8 head, virgin 20-day female    3 head, mated 1-day female    8 head, mated 4-day female    9 head, mated 20-day female    4 head, mated 1-day male    7 head, mated 4-day male    12 head, mated 20-day male    11 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    5 digestive system, 4-day adult    15 digestive system, 20-day adult    9 fat body, larvae L3 wandering    12 fat body, white prepupae    16 fat body, pupae P8    12 carcass, larvae L3 wandering  (46) carcass, 1-day adult    9 carcass, 4-day adult    15 carcass, 20-day adult    10 ovary, virgin 4-day female  (86) ovary, mated 4-day female  (188) testis, mated 4-day male  (57) accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    56 central nervous system, larvae L3    99 central nervous system, pupae P8    16 head, virgin 1-day female    6 head, virgin 4-day female    8 head, virgin 20-day female    3 head, mated 1-day female    8 head, mated 4-day female    9 head, mated 20-day female    4 head, mated 1-day male    7 head, mated 4-day male    12 head, mated 20-day male    11 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    5 digestive system, 4-day adult    15 digestive system, 20-day adult    9 fat body, larvae L3 wandering    12 fat body, white prepupae    16 fat body, pupae P8    12 carcass, larvae L3 wandering    46 carcass, 1-day adult    9 carcass, 4-day adult    15 carcass, 20-day adult    10 ovary, virgin 4-day female    86 ovary, mated 4-day female  (188) testis, mated 4-day male    57 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    56 central nervous system, larvae L3    99 central nervous system, pupae P8    16 head, virgin 1-day female    6 head, virgin 4-day female    8 head, virgin 20-day female    3 head, mated 1-day female    8 head, mated 4-day female    9 head, mated 20-day female    4 head, mated 1-day male    7 head, mated 4-day male    12 head, mated 20-day male    11 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    5 digestive system, 4-day adult    15 digestive system, 20-day adult    9 fat body, larvae L3 wandering    12 fat body, white prepupae    16 fat body, pupae P8    12 carcass, larvae L3 wandering    46 carcass, 1-day adult    9 carcass, 4-day adult    15 carcass, 20-day adult    10 ovary, virgin 4-day female    86 ovary, mated 4-day female    188 testis, mated 4-day male    57 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    83 embryo 02-04hr    140 embryo 04-06hr    156 embryo 06-08hr    77 embryo 08-10hr    62 embryo 10-12hr    34 embryo 12-14hr    26 embryo 14-16hr    26 embryo 16-18hr    22 embryo 18-20hr    11 embryo 20-22hr    29 embryo 22-24hr    24 larva L1    17 larva L2    22 larva L3 12hr old    15 larva L3 puffstage 1-2    21 larva L3 puffstage 3-6    26 larva L3 puffstage 7-9    28 white prepupae new    27 white prepupae 12hr    33 white prepupae 24hr    34 pupae 2d postWPP    19 pupae 3d postWPP    14 pupae 4d postWPP    15 adult male 01day    18 adult male 05day    24 adult male 30day    24 adult female 01day    31 adult female 05day    53 adult female 30day    53 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (83) embryo 02-04hr  (140) embryo 04-06hr  (156) embryo 06-08hr  (77) embryo 08-10hr  (62) embryo 10-12hr  (34) embryo 12-14hr  26 embryo 14-16hr  26 embryo 16-18hr    22 embryo 18-20hr    11 embryo 20-22hr  (29) embryo 22-24hr    24 larva L1    17 larva L2    22 larva L3 12hr old    15 larva L3 puffstage 1-2    21 larva L3 puffstage 3-6  26 larva L3 puffstage 7-9  (28) white prepupae new  (27) white prepupae 12hr  (33) white prepupae 24hr  (34) pupae 2d postWPP    19 pupae 3d postWPP    14 pupae 4d postWPP    15 adult male 01day    18 adult male 05day    24 adult male 30day    24 adult female 01day  (31) adult female 05day  (53) adult female 30day  (53) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    83 embryo 02-04hr  (140) embryo 04-06hr  (156) embryo 06-08hr    77 embryo 08-10hr    62 embryo 10-12hr    34 embryo 12-14hr    26 embryo 14-16hr    26 embryo 16-18hr    22 embryo 18-20hr    11 embryo 20-22hr    29 embryo 22-24hr    24 larva L1    17 larva L2    22 larva L3 12hr old    15 larva L3 puffstage 1-2    21 larva L3 puffstage 3-6    26 larva L3 puffstage 7-9    28 white prepupae new    27 white prepupae 12hr    33 white prepupae 24hr    34 pupae 2d postWPP    19 pupae 3d postWPP    14 pupae 4d postWPP    15 adult male 01day    18 adult male 05day    24 adult male 30day    24 adult female 01day    31 adult female 05day    53 adult female 30day    53 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    83 embryo 02-04hr    140 embryo 04-06hr    156 embryo 06-08hr    77 embryo 08-10hr    62 embryo 10-12hr    34 embryo 12-14hr    26 embryo 14-16hr    26 embryo 16-18hr    22 embryo 18-20hr    11 embryo 20-22hr    29 embryo 22-24hr    24 larva L1    17 larva L2    22 larva L3 12hr old    15 larva L3 puffstage 1-2    21 larva L3 puffstage 3-6    26 larva L3 puffstage 7-9    28 white prepupae new    27 white prepupae 12hr    33 white prepupae 24hr    34 pupae 2d postWPP    19 pupae 3d postWPP    14 pupae 4d postWPP    15 adult male 01day    18 adult male 05day    24 adult male 30day    24 adult female 01day    31 adult female 05day    53 adult female 30day    53 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    83 embryo 02-04hr    140 embryo 04-06hr    156 embryo 06-08hr    77 embryo 08-10hr    62 embryo 10-12hr    34 embryo 12-14hr    26 embryo 14-16hr    26 embryo 16-18hr    22 embryo 18-20hr    11 embryo 20-22hr    29 embryo 22-24hr    24 larva L1    17 larva L2    22 larva L3 12hr old    15 larva L3 puffstage 1-2    21 larva L3 puffstage 3-6    26 larva L3 puffstage 7-9    28 white prepupae new    27 white prepupae 12hr    33 white prepupae 24hr    34 pupae 2d postWPP    19 pupae 3d postWPP    14 pupae 4d postWPP    15 adult male 01day    18 adult male 05day    24 adult male 30day    24 adult female 01day    31 adult female 05day    53 adult female 30day    53 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (83) embryo 02-04hr  (140) embryo 04-06hr  (156) embryo 06-08hr  (77) embryo 08-10hr  (62) embryo 10-12hr  (34) embryo 12-14hr  26 embryo 14-16hr  26 embryo 16-18hr    22 embryo 18-20hr    11 embryo 20-22hr  29 embryo 22-24hr    24 larva L1    17 larva L2    22 larva L3 12hr old    15 larva L3 puffstage 1-2    21 larva L3 puffstage 3-6  26 larva L3 puffstage 7-9  28 white prepupae new  27 white prepupae 12hr  (33) white prepupae 24hr  (34) pupae 2d postWPP    19 pupae 3d postWPP    14 pupae 4d postWPP    15 adult male 01day    18 adult male 05day    24 adult male 30day    24 adult female 01day  31 adult female 05day  (53) adult female 30day  (53) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    83 embryo 02-04hr  140 embryo 04-06hr  (156) embryo 06-08hr    77 embryo 08-10hr    62 embryo 10-12hr    34 embryo 12-14hr    26 embryo 14-16hr    26 embryo 16-18hr    22 embryo 18-20hr    11 embryo 20-22hr    29 embryo 22-24hr    24 larva L1    17 larva L2    22 larva L3 12hr old    15 larva L3 puffstage 1-2    21 larva L3 puffstage 3-6    26 larva L3 puffstage 7-9    28 white prepupae new    27 white prepupae 12hr    33 white prepupae 24hr    34 pupae 2d postWPP    19 pupae 3d postWPP    14 pupae 4d postWPP    15 adult male 01day    18 adult male 05day    24 adult male 30day    24 adult female 01day    31 adult female 05day    53 adult female 30day    53 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    83 embryo 02-04hr    140 embryo 04-06hr    156 embryo 06-08hr    77 embryo 08-10hr    62 embryo 10-12hr    34 embryo 12-14hr    26 embryo 14-16hr    26 embryo 16-18hr    22 embryo 18-20hr    11 embryo 20-22hr    29 embryo 22-24hr    24 larva L1    17 larva L2    22 larva L3 12hr old    15 larva L3 puffstage 1-2    21 larva L3 puffstage 3-6    26 larva L3 puffstage 7-9    28 white prepupae new    27 white prepupae 12hr    33 white prepupae 24hr    34 pupae 2d postWPP    19 pupae 3d postWPP    14 pupae 4d postWPP    15 adult male 01day    18 adult male 05day    24 adult male 30day    24 adult female 01day    31 adult female 05day    53 adult female 30day    53 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    89 Schneider line 2 Sg4    70 embryonic 1182-4H    105 embryonic GM2    46 embryonic Kc167    42 embryonic S1    88 embryonic S3    78 leg disc CME L1    124 wing disc CME-W2    59 wing disc ML-DmD8    65 wing disc ML-DmD9    84 wing disc ML-DmD16-c3    192 wing disc ML-DmD21    146 wing disc ML-DmD32    100 haltere disc ML-DmD17-c3    100 eye-antennal disc ML-DmD11    116 antennal disc ML-DmD20-c5    83 mixed discs ML-DmD4-c1    137 CNS ML-DmBG1-c1    182 CNS ML-DmBG2-c2    60 tumorous blood cells mbn2    36 ovary fGS/OSS    238 ovary OSC    232 ovary OSS    291 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (89) Schneider line 2 Sg4  (70) embryonic 1182-4H  (105) embryonic GM2  (46) embryonic Kc167  (42) embryonic S1  (88) embryonic S3  (78) leg disc CME L1  (124) wing disc CME-W2  (59) wing disc ML-DmD8  (65) wing disc ML-DmD9  (84) wing disc ML-DmD16-c3  (192) wing disc ML-DmD21  (146) wing disc ML-DmD32  (100) haltere disc ML-DmD17-c3  (100) eye-antennal disc ML-DmD11  (116) antennal disc ML-DmD20-c5  (83) mixed discs ML-DmD4-c1  (137) CNS ML-DmBG1-c1  (182) CNS ML-DmBG2-c2  (60) tumorous blood cells mbn2  (36) ovary fGS/OSS  (238) ovary OSC  (232) ovary OSS  (291) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    89 Schneider line 2 Sg4    70 embryonic 1182-4H  105 embryonic GM2    46 embryonic Kc167    42 embryonic S1    88 embryonic S3    78 leg disc CME L1  (124) wing disc CME-W2    59 wing disc ML-DmD8    65 wing disc ML-DmD9    84 wing disc ML-DmD16-c3  (192) wing disc ML-DmD21  (146) wing disc ML-DmD32    100 haltere disc ML-DmD17-c3    100 eye-antennal disc ML-DmD11  (116) antennal disc ML-DmD20-c5    83 mixed discs ML-DmD4-c1  (137) CNS ML-DmBG1-c1  (182) CNS ML-DmBG2-c2    60 tumorous blood cells mbn2    36 ovary fGS/OSS  (238) ovary OSC  (232) ovary OSS  (291) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    89 Schneider line 2 Sg4    70 embryonic 1182-4H    105 embryonic GM2    46 embryonic Kc167    42 embryonic S1    88 embryonic S3    78 leg disc CME L1    124 wing disc CME-W2    59 wing disc ML-DmD8    65 wing disc ML-DmD9    84 wing disc ML-DmD16-c3    192 wing disc ML-DmD21    146 wing disc ML-DmD32    100 haltere disc ML-DmD17-c3    100 eye-antennal disc ML-DmD11    116 antennal disc ML-DmD20-c5    83 mixed discs ML-DmD4-c1    137 CNS ML-DmBG1-c1    182 CNS ML-DmBG2-c2    60 tumorous blood cells mbn2    36 ovary fGS/OSS    238 ovary OSC    232 ovary OSS    291 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    89 Schneider line 2 Sg4    70 embryonic 1182-4H    105 embryonic GM2    46 embryonic Kc167    42 embryonic S1    88 embryonic S3    78 leg disc CME L1    124 wing disc CME-W2    59 wing disc ML-DmD8    65 wing disc ML-DmD9    84 wing disc ML-DmD16-c3    192 wing disc ML-DmD21    146 wing disc ML-DmD32    100 haltere disc ML-DmD17-c3    100 eye-antennal disc ML-DmD11    116 antennal disc ML-DmD20-c5    83 mixed discs ML-DmD4-c1    137 CNS ML-DmBG1-c1    182 CNS ML-DmBG2-c2    60 tumorous blood cells mbn2    36 ovary fGS/OSS    238 ovary OSC    232 ovary OSS    291 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (89) Schneider line 2 Sg4  (70) embryonic 1182-4H  (105) embryonic GM2  (46) embryonic Kc167  (42) embryonic S1  (88) embryonic S3  (78) leg disc CME L1  (124) wing disc CME-W2  (59) wing disc ML-DmD8  (65) wing disc ML-DmD9  (84) wing disc ML-DmD16-c3  (192) wing disc ML-DmD21  (146) wing disc ML-DmD32  (100) haltere disc ML-DmD17-c3  (100) eye-antennal disc ML-DmD11  (116) antennal disc ML-DmD20-c5  (83) mixed discs ML-DmD4-c1  (137) CNS ML-DmBG1-c1  (182) CNS ML-DmBG2-c2  (60) tumorous blood cells mbn2  (36) ovary fGS/OSS  (238) ovary OSC  (232) ovary OSS  (291) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    89 Schneider line 2 Sg4    70 embryonic 1182-4H  105 embryonic GM2    46 embryonic Kc167    42 embryonic S1    88 embryonic S3    78 leg disc CME L1  124 wing disc CME-W2    59 wing disc ML-DmD8    65 wing disc ML-DmD9    84 wing disc ML-DmD16-c3  (192) wing disc ML-DmD21  (146) wing disc ML-DmD32    100 haltere disc ML-DmD17-c3    100 eye-antennal disc ML-DmD11  116 antennal disc ML-DmD20-c5    83 mixed discs ML-DmD4-c1  137 CNS ML-DmBG1-c1  (182) CNS ML-DmBG2-c2    60 tumorous blood cells mbn2    36 ovary fGS/OSS  (238) ovary OSC  (232) ovary OSS  (291) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    89 Schneider line 2 Sg4    70 embryonic 1182-4H    105 embryonic GM2    46 embryonic Kc167    42 embryonic S1    88 embryonic S3    78 leg disc CME L1    124 wing disc CME-W2    59 wing disc ML-DmD8    65 wing disc ML-DmD9    84 wing disc ML-DmD16-c3    192 wing disc ML-DmD21    146 wing disc ML-DmD32    100 haltere disc ML-DmD17-c3    100 eye-antennal disc ML-DmD11    116 antennal disc ML-DmD20-c5    83 mixed discs ML-DmD4-c1    137 CNS ML-DmBG1-c1    182 CNS ML-DmBG2-c2    60 tumorous blood cells mbn2    36 ovary fGS/OSS    238 ovary OSC    232 ovary OSS    291 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    110 cold shock, 4-day adult    63 heat shock, 4-day adult    58 Cadmium 50 mM 6 hrs, larvae L3    24 Cadmium 50 mM 12 hrs, larvae L3    22 Cadmium 50 mM 48 hrs, 4-day adult    59 Cadmium 100 mM 48 hrs, 4-day adult    114 Copper 0.5 mM 12 hrs, larvae L3    83 Copper 15 mM 48 hrs, 4-day adult    97 Zinc 5 mM 12 hrs, larvae L3    45 Zinc 4.5 mM 48 hrs, 4-day adult    74 Ethanol 2.5% 3 hrs, larvae L3    74 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    103 Caffeine 25 mg/ml 48 hrs, 4-day adult    131 Paraquat 5 mM 48 hrs, 4-day adult    96 Paraquat 10 mM 48 hrs, 4-day adult    50 Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (110) cold shock, 4-day adult  (63) heat shock, 4-day adult  (58) Cadmium 50 mM 6 hrs, larvae L3    24 Cadmium 50 mM 12 hrs, larvae L3    22 Cadmium 50 mM 48 hrs, 4-day adult  (59) Cadmium 100 mM 48 hrs, 4-day adult  (114) Copper 0.5 mM 12 hrs, larvae L3  (83) Copper 15 mM 48 hrs, 4-day adult  (97) Zinc 5 mM 12 hrs, larvae L3  (45) Zinc 4.5 mM 48 hrs, 4-day adult  (74) Ethanol 2.5% 3 hrs, larvae L3  (74) Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (103) Caffeine 25 mg/ml 48 hrs, 4-day adult  (131) Paraquat 5 mM 48 hrs, 4-day adult  (96) Paraquat 10 mM 48 hrs, 4-day adult  (50) Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    16 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (110) cold shock, 4-day adult    63 heat shock, 4-day adult    58 Cadmium 50 mM 6 hrs, larvae L3    24 Cadmium 50 mM 12 hrs, larvae L3    22 Cadmium 50 mM 48 hrs, 4-day adult    59 Cadmium 100 mM 48 hrs, 4-day adult  (114) Copper 0.5 mM 12 hrs, larvae L3    83 Copper 15 mM 48 hrs, 4-day adult    97 Zinc 5 mM 12 hrs, larvae L3    45 Zinc 4.5 mM 48 hrs, 4-day adult    74 Ethanol 2.5% 3 hrs, larvae L3    74 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  103 Caffeine 25 mg/ml 48 hrs, 4-day adult  (131) Paraquat 5 mM 48 hrs, 4-day adult    96 Paraquat 10 mM 48 hrs, 4-day adult    50 Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    110 cold shock, 4-day adult    63 heat shock, 4-day adult    58 Cadmium 50 mM 6 hrs, larvae L3    24 Cadmium 50 mM 12 hrs, larvae L3    22 Cadmium 50 mM 48 hrs, 4-day adult    59 Cadmium 100 mM 48 hrs, 4-day adult    114 Copper 0.5 mM 12 hrs, larvae L3    83 Copper 15 mM 48 hrs, 4-day adult    97 Zinc 5 mM 12 hrs, larvae L3    45 Zinc 4.5 mM 48 hrs, 4-day adult    74 Ethanol 2.5% 3 hrs, larvae L3    74 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    103 Caffeine 25 mg/ml 48 hrs, 4-day adult    131 Paraquat 5 mM 48 hrs, 4-day adult    96 Paraquat 10 mM 48 hrs, 4-day adult    50 Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    16 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    110 cold shock, 4-day adult    63 heat shock, 4-day adult    58 Cadmium 50 mM 6 hrs, larvae L3    24 Cadmium 50 mM 12 hrs, larvae L3    22 Cadmium 50 mM 48 hrs, 4-day adult    59 Cadmium 100 mM 48 hrs, 4-day adult    114 Copper 0.5 mM 12 hrs, larvae L3    83 Copper 15 mM 48 hrs, 4-day adult    97 Zinc 5 mM 12 hrs, larvae L3    45 Zinc 4.5 mM 48 hrs, 4-day adult    74 Ethanol 2.5% 3 hrs, larvae L3    74 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    103 Caffeine 25 mg/ml 48 hrs, 4-day adult    131 Paraquat 5 mM 48 hrs, 4-day adult    96 Paraquat 10 mM 48 hrs, 4-day adult    50 Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (110) cold shock, 4-day adult  (63) heat shock, 4-day adult  (58) Cadmium 50 mM 6 hrs, larvae L3    24 Cadmium 50 mM 12 hrs, larvae L3    22 Cadmium 50 mM 48 hrs, 4-day adult  (59) Cadmium 100 mM 48 hrs, 4-day adult  (114) Copper 0.5 mM 12 hrs, larvae L3  (83) Copper 15 mM 48 hrs, 4-day adult  (97) Zinc 5 mM 12 hrs, larvae L3  (45) Zinc 4.5 mM 48 hrs, 4-day adult  (74) Ethanol 2.5% 3 hrs, larvae L3  (74) Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (103) Caffeine 25 mg/ml 48 hrs, 4-day adult  (131) Paraquat 5 mM 48 hrs, 4-day adult  (96) Paraquat 10 mM 48 hrs, 4-day adult  (50) Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    16 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  110 cold shock, 4-day adult    63 heat shock, 4-day adult    58 Cadmium 50 mM 6 hrs, larvae L3    24 Cadmium 50 mM 12 hrs, larvae L3    22 Cadmium 50 mM 48 hrs, 4-day adult    59 Cadmium 100 mM 48 hrs, 4-day adult  114 Copper 0.5 mM 12 hrs, larvae L3    83 Copper 15 mM 48 hrs, 4-day adult    97 Zinc 5 mM 12 hrs, larvae L3    45 Zinc 4.5 mM 48 hrs, 4-day adult    74 Ethanol 2.5% 3 hrs, larvae L3    74 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  103 Caffeine 25 mg/ml 48 hrs, 4-day adult  131 Paraquat 5 mM 48 hrs, 4-day adult    96 Paraquat 10 mM 48 hrs, 4-day adult    50 Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    110 cold shock, 4-day adult    63 heat shock, 4-day adult    58 Cadmium 50 mM 6 hrs, larvae L3    24 Cadmium 50 mM 12 hrs, larvae L3    22 Cadmium 50 mM 48 hrs, 4-day adult    59 Cadmium 100 mM 48 hrs, 4-day adult    114 Copper 0.5 mM 12 hrs, larvae L3    83 Copper 15 mM 48 hrs, 4-day adult    97 Zinc 5 mM 12 hrs, larvae L3    45 Zinc 4.5 mM 48 hrs, 4-day adult    74 Ethanol 2.5% 3 hrs, larvae L3    74 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    103 Caffeine 25 mg/ml 48 hrs, 4-day adult    131 Paraquat 5 mM 48 hrs, 4-day adult    96 Paraquat 10 mM 48 hrs, 4-day adult    50 Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_17 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • LD16356 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003346 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9999-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for RanGAP Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal RanGAPGD4386 partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 RanGAPGD4386 Other Phenotypes Allele meiotic cell cycle defective RanGAPSD meiotic cell cycle defective | dominant RanGAPSd.tPa.5 RanGAPSd.tPa neuroanatomy defective | larval stage RanGAPGD4386 visible, with Scer\GAL4pnr-MD237 RanGAPGD4386 Phenotype manifest in Allele embryonic/larval neuroblast | larval stage RanGAPGD4386 ganglion mother cell | larval stage RanGAPGD4386 mesothoracic tergum, with Scer\GAL4pnr-MD237 RanGAPGD4386 spermatid RanGAPSD
Classical Alleles ( 14 )
For All Classical Alleles Show
Allele of RanGAP Class Mutagen Stocks Known lesion RanGAPSD gain of function allele natural population 4 Yes RanGAPEP1173 P-element activity 2 -- RanGAPc07031 piggyBac transposase 1 -- RanGAPc07037 piggyBac transposase 1 -- RanGAPEY21763 P-element activity 1 -- RanGAPc07034 piggyBac transposase 0 -- RanGAPSd-ER2 ethyl methanesulfonate 0 Yes RanGAPSd-ER5 ethyl methanesulfonate 0 Yes RanGAPSd-ER8.2 ethyl methanesulfonate 0 Yes RanGAPSd-ER8 ethyl methanesulfonate 0 Yes RanGAPSd-R19 X ray 0 Yes RanGAPSd-Rev1 spontaneous 0 Yes RanGAPSd-Rev2 spontaneous 0 Yes RanGAPSd.tPa.5 P-element activity 0 --
Alleles Carried on Transgenic Constructs ( 17 )
For All Alleles Carried on Transgenic Constructs Show
Allele of RanGAP Class Mutagen Stocks Known lesion RanGAPGD4386 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes RanGAPJF03244 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes RanGAPKK102830 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes RanGAPNIG.9999R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes RanGAPR87A.βTub85D in vitro construct - site directed mutagenesis 0 Yes RanGAPScer\UAS.T:Zzzz\FLAG,T:Zzzz\BLRP,T:Disc\RFP-mCherry in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes RanGAPSd.12A in vitro construct 0 Yes RanGAPSd.D241A in vitro construct - amino acid replacement 0 Yes RanGAPSd.E189A in vitro construct - amino acid replacement 0 Yes RanGAPSd.R87A in vitro construct - amino acid replacement 0 Yes RanGAPSd.T:Ivir\HA1,T:Ocun\nes-P12 in vitro construct - coding region fusion 0 Yes RanGAPSd.T:Ivir\HA1,T:Ocun\nes in vitro construct - coding region fusion 0 Yes RanGAPSd.T:Ivir\HA1 in vitro construct - coding region fusion 0 Yes RanGAPSd.tPa.1 P-element activity 0 Yes RanGAPSd.tPa in vitro construct 0 Yes RanGAPtwi.T:Zzzz\FLAG,T:Zzzz\BLRP,T:Disc\RFP-mCherry in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes RanGAPβTub85D.PK in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Partially duplicated in	Dp(2;2)RanGapSD (Merrill et al., 1999)
Disrupted in	Df(2L)E55 (Brittnacher and Ganetzky, 1983) Df(2L)Exel7075 (Ryder, 2004.4.26) Df(2L)Exel7076 (Ryder, 2004.4.26) Df(2L)Exel8041 (Ryder, 2004.4.26) Df(2L)pr-A8 (Ganetzky, 1977) Df(2L)pr-A14 (Ganetzky, 1977) Df(2L)pr-A16 (Ganetzky, 1977) Df(2L)Sd2 (Brittnacher and Ganetzky, 1983, Brittnacher and Ganetzky, 1984, Temin, 1991) Df(2L)Sd14 (Brittnacher and Ganetzky, 1983, Brittnacher and Ganetzky, 1984, Powers and Ganetzky, 1991, Temin, 1991) Df(2L)Sd37 (Ganetzky, 1977, Brittnacher and Ganetzky, 1983, Brittnacher and Ganetzky, 1984, Temin, 1991, McLean et al., 1994) Df(2L)Sd57 (Brittnacher and Ganetzky, 1983, Brittnacher and Ganetzky, 1984, Temin, 1991) Df(2L)Sd68 (Brittnacher and Ganetzky, 1983, Temin, 1991) Df(2L)Sd77 (Brittnacher and Ganetzky, 1983, Brittnacher and Ganetzky, 1984, Temin, 1991, McLean et al., 1994) Df(2L)TW158 (Palopoli and Wu, 1996) Df(2L)VA6 (Brittnacher and Ganetzky, 1983) Df(2L)VA8 (Brittnacher and Ganetzky, 1983) Dp(2;Y)R10 (Temin, 1991)
Not disrupted in	Df(2L)E71 (Ganetzky, 1977, Brittnacher and Ganetzky, 1983) Df(2L)hk18 (Brittnacher and Ganetzky, 1983) Df(2L)hk39 (Brittnacher and Ganetzky, 1983) Df(2L)pr21 (Brittnacher and Ganetzky, 1983) Df(2L)pr26 (Brittnacher and Ganetzky, 1983) Df(2L)pr47 (Brittnacher and Ganetzky, 1983) Df(2L)pr49 (Brittnacher and Ganetzky, 1983) Df(2L)pr65 (Brittnacher and Ganetzky, 1983) Df(2L)pr67 (Brittnacher and Ganetzky, 1983) Df(2L)pr69 (Brittnacher and Ganetzky, 1983) Df(2L)pr-B12 (Brittnacher and Ganetzky, 1983) Df(2L)TW2 (Brittnacher and Ganetzky, 1983) Df(2L)TW130 (Brittnacher and Ganetzky, 1983) Df(2L)VA14 (Brittnacher and Ganetzky, 1983) Df(2L)VA16 (Brittnacher and Ganetzky, 1983)
Duplicated in	Dp(2;Y)c53 (Golic, 1990, Temin, 1991) Dp(2;Y)G (Lyttle, 1986) Dp(2;Y)Sd (Temin, 1991)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}RanGAPEP1173 NA P{EPgy2}RanGAPEY21763 NA miscellaneous insertions P{Sd.P}5 NA PBac{PB}RanGAPc07031 NA PBac{PB}RanGAPc07034 NA PBac{PB}RanGAPc07037 NA
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function
CV term Evidence References
Ran GTPase activator activity inferred from direct assay (Kusano et al., 2001)
Biological Process
CV term Evidence References
neurogenesis inferred from mutant phenotype (Neumüller et al., 2011)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
Ran GTPase activator activity non-traceable author statement (Merrill, 1999.4.16, Johnson, 2002, Merrill et al., 1998)
Biological Process
CV term Evidence References
meiotic chromosome segregation traceable author statement (Kusano et al., 2003) nucleocytoplasmic transport non-traceable author statement (Kusano et al., 2003, Johnson, 2002)
Cellular Component
CV term Evidence References
cytoplasm non-traceable author statement (Johnson, 2002, Swiss-Prot Project Members, 2002.3.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
RanGAP - 5-HT7 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RanGAP - AIF experimental knowledge based (Guruharsha et al., 2011) RanGAP - Bub1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RanGAP - CG12057 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RanGAP - CG1513 experimental knowledge based (Guruharsha et al., 2011) RanGAP - CG1603 experimental knowledge based (Guruharsha et al., 2011) RanGAP - CG33523 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RanGAP - CG4908 experimental knowledge based (Guruharsha et al., 2011) RanGAP - CG9205 experimental knowledge based (Guruharsha et al., 2011) RanGAP - CG9723 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) RanGAP - Dredd anti tag coimmunoprecipitation, peptide massfingerprinting (Fukuyama et al., 2012) RanGAP - Fs(2)Ket experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) RanGAP - GAPcenA experimental knowledge based (Guruharsha et al., 2011) RanGAP - Nup358 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) RanGAP - Nxt1 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) RanGAP - Orc5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RanGAP - Pk92B experimental knowledge based (Guruharsha et al., 2011) RanGAP - Ran anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RanGAP - RnrL anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RanGAP - Sk2 experimental knowledge based (Guruharsha et al., 2011) RanGAP - az2 experimental knowledge based (Guruharsha et al., 2011) RanGAP - cert experimental knowledge based (Guruharsha et al., 2011) RanGAP - coro anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RanGAP - l(2)k01209 experimental knowledge based (Guruharsha et al., 2011) RanGAP - mib2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RanGAP - rdgB experimental knowledge based (Guruharsha et al., 2011) RanGAP - sbr experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions RanGAP allele Gene References RanGapSD Ran (Kusano et al., 2001) Rcc1 (Kusano et al., 2001) Su(Sd)2a-1 (McDaniel et al., 2002) Su(Sd)4a-2 (McDaniel et al., 2002)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 61202 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0003346 DroID - A comprehensive database of gene and protein interactions. • FBgn0003346 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35223
Orthologs
OrthoDB Orthologs (41) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG62NJK1 Dipteran inclusive ortholog search EOG6G7C6Q Insect inclusive ortholog search EOG6NK9QT Arthropod inclusive ortholog search EOG6DJHBP Metazoa inclusive ortholog search EOG6NSG4R
Orthologs in Drosophila Species (EOG62NJK1)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\RanGAP     Drosophila simulans   Dsim\GD12035     Drosophila sechellia   Dsec\GM17349 Y   Drosophila erecta   Dere\GG21182 Y   Drosophila yakuba   Dyak\GE13255 Y   Drosophila ananassae   Dana\GF14235 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA22178 Y   Drosophila persimilis   Dper\GL21210 Y   Drosophila willistoni   Dwil\GK24798 Y   Drosophila virilis   Dvir\GJ18130 Y   Drosophila mojavensis   Dmoj\GI18223 Y   Drosophila grimshawi   Dgri\GH11099 Y
Orthologs in non-Drosophila Dipterans (EOG6G7C6Q)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL007858   Anopheles gambiae Malaria mosquito  Agam\AGAP008267   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ801427
Orthologs in non-Dipteran Insects (EOG6NK9QT)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB48170   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG015003   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH13396   Atta cephalotes Leafcutter ant  Acep\ACEP24792   Camponotus floridanus Florida carpenter ant  Cflo\CFLO22239   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL15832   Linepithema humile Argentine ant  Lhum\LH21696   Pogonomyrmex barbatus Red harvester ant  Pbar\PB13204   Solenopsis invicta Red fire ant  Sinv\SINV24850   Acyrthosiphon pisum Pea aphid  Apim\ACYPI009742   Bombyx mori Silkmoth  Bmor\BGIBMGA001699   Pediculus humanus Human body louse  Phum\PHUM475800   Tribolium castaneum Red flour beetle  Tcas\TC002993
Orthologs in non-Insect Arthropods (EOG6DJHBP)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Fuk   Ixodes scapularis Deer tick  Isca\ISCW016093
Orthologs in non-Arthropod Metazoa (EOG6NSG4R)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\ran-2   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_004276gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_019616gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_000168gn   Danio rerio Zebrafish  Drer\rangap1   Danio rerio Zebrafish  Drer\zgc:154097   Xenopus tropicalis Western clawed frog  Xtro\rangap1   Gallus gallus Domestic chicken  Ggal\RANGAP1   Mus musculus House mouse  Mmus\Rangap1   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000031789   Homo sapiens Human  Hsap\RANGAP1
Human Orthologs (1)
Gene OMIM HGNC Hsap\RANGAP1
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD24207 Drosophila sechellia Dsec\GM17349 Drosophila erecta Dere\GG21182 Drosophila yakuba Dyak\GE13255 Drosophila ananassae Dana\GF14235 Drosophila pseudoobscura pseudoobscura Dpse\GA22178 Drosophila persimilis Dper\GL21210 Drosophila willistoni Dwil\GK24798 Drosophila virilis Dvir\GJ18130 Drosophila mojavensis Dmoj\GI18223 Drosophila grimshawi Dgri\GH11099
Stocks & Reagents
Stocks Listed in FlyBase ( 12 )
Bloomington	16995 w1118; P{EP}RanGAPEP1173/CyO 22503 y1 w67c23; P{EPgy2}RanGAPEY21763 29565 y1 v1; P{TRiP.JF03244}attP2/TM3, Sb1 393 In(2R)SD5, In(2R)NS, Dp(2;2)RanGapSD, RanGAPSD/SM1 394 In(2LR)SD72, In(2R)NS, Dp(2;2)RanGapSD, RanGAPSD/SM5
Harvard	- PBac{PB}RanGAPc07031 - PBac{PB}RanGAPc07037
Kyoto	105887 In(2R)SD5, In(2R)NS, Dp(2;2)RanGapSD, RanGAPSD/SM1 105888 In(2LR)SD72, In(2R)NS, Dp(2;2)RanGapSD, RanGAPSD/SM5 114633 yd2 w1118 P{ey-FLP.N}2; P{EP}RanGAPEP1173 P{neoFRT}40A/CyO y+
VDRC	v108264 P{KK102830}VIE-260B v30568 w1118; P{GD4386}v30568/TM3
Genomic Clones ( 2 )
	BACR27M12 BACR28G24 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 59 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD16356
Other clones	DPiM_LD16356
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM03602 GM08054 GM12882 GM15163 GM21062 GM23802 GM32255 LD02279 LD06018 LD10270 LD10545 LD17282 LD19948 LD20516 LD20904 LD26770 LD34112 LD34123 LD35996 LD37136 LD38617 LD38792 LD41703 LD47959 LP09655 RE02608 RE19518 RE24676 RE25975 RE40870 RE55272 RE56551 RE63165 RE64244 RE74115 RE74881 SD02041 SD11342 SD14470 SD19230
Other clones	45075 63926 72400 77054 214469.24 214537.34 CK01.16C.A12 CK01.65C.H7 Dmel_neb_007637_0197_1419 Dmel_neb_011827_0697_3576 EK053332 EK128623 EK160924 EK200941 EP09857 EP11961 FGM310E12
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0003346 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35223
Antibody Information
	polyclonal (Merrill et al., 1999)
Other Information
Discoverer
	Hiraizumi.
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: RanGAP RanGap (FlyBase, 2009-)
Source for database merge of
Additional comments	FlyBase curator comment: 'RanGap' changed to 'RanGAP' to capitalize the 'GAP' to be consistent with all other GAP gene symbols. (FlyBase, 2009-)
Other Comments
	Area matching Drosophila gene RanGAP, Acc. No. AF143860. (Davies, 2001.3.15) The truncated RanGap product encoded by SD distorting chromosomes (RanGapSD) retains normal enzyme activity, but has abnormal subcellular location, being distributed diffusely throughout the cytoplasm and also having a distinct nuclear component in primary spermatocytes and salivary gland cells. Mislocalisation of the active RanGapSD product to the nucleus is responsible for segregation distortion (distortion is abolished if enzymatic activity or nuclear localisation of the RanGapSD product is perturbed). (Kusano et al., 2001) SD chromosomes have a tandem duplication at the RanGap locus. Distortion is caused by a truncated RanGap product encoded by the distal half of the duplication. (Merrill et al., 1999) A mutation of RanGap generated by loss of a P-element in RanGap exhibits a maternal effect embryonic lethal phenotype. Homozygous females are completely normal but hemizygotes are sterile regardless of the genotype of the male. Embryos from these females die before the syncytial blastoderm stage, around the 7th or 8th nuclear division. In addition, their nuclei are no longer mitotically synchronous and many appear abnormal in size and shape. (McLean et al., 1997) Encodes a Ran GTPase activator.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057364 NM_001273649 NM_001273650 RefSeq (Proteins) • NP_476712 NP_001260578 NP_001260579 DDBJ / EMBL / GenBank • AA441427 AAD31518 AAF53801 AAL28767 AC005428 AC007082 AF143860 AGB93113 AGB93114 AQ025044 AW942414 AX094031 AY061219 CZ471178 CZ471183 CZ471187 Entrez Gene - A searchable database of RefSeq genes. • 35223 UniProtKB/Swiss-Prot • Q9VIW3
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Ran GTPase-activating protein (IPR027038) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD16356
Linkouts
	BioGRID - A database of protein and genetic interactions • 61202 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0003346 DroID - A comprehensive database of gene and protein interactions. • FBgn0003346 DRSC - Results from RNAi screens. • FBgn0003346 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003346 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9999-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0003346 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35223 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35223 modMine - Data generated by the modENCODE project. • FBgn0003346
Synonyms & Secondary IDs ( 19 )
Reported As
Symbol Synonym	CG9999 (Giot et al., 2003, Brody et al., 2002, Mason and Goldfarb, 2009, Keleman et al., 2009.8.5, Haussmann et al., 2008, Perkins et al., 2009) CT28175 (Hynes and Zhao, 2000) dRanGAP (Merrill et al., 1999) Ran (Kim et al., 2008) rangap (Merrill et al., 1998) RanGAP (Johnson, 2002, Kusano et al., 2003, Trieselmann and Wilde, 2002, Kusano et al., 2001, McElroy and McLean, 2006, Silverman-Gavrila and Wilde, 2006, Roth et al., 2003, Cesario and McKim, 2011, Xylourgidis et al., 2006, Minakhina et al., 2005, Moshkin et al., 2009, Liu et al., 2011, ) ranGAP (Minakhina et al., 2004, Reid et al., 2012) ranGap (Mason and Goldfarb, 2009) RanGap (Casper and Van Doren, 2009, Obbard et al., 2009, Japanese National Institute of Genetics, 2012.5.21, Sinkins and Gould, 2006, Steiner et al., 2012, Bakal et al., 2007, Neumüller et al., 2011, Schrider et al., 2011) RanGap1 (Houtchens and Lyttle, 2003) RGP1_DROME (Fukuyama et al., 2012) Scl (Hynes and Zhao, 2000) Sd (Gibson et al., 2005, Barrio and de Celis, 2004, Dominguez et al., 1993, Hiraizumi, 1993, Gatti and Pimpinelli, 1992, Hiraizumi, 1990, Hiraizumi et al., 1980, Hiraizumi, 1989, Brittnacher and Ganetzky, 1983, Walker et al., 1989, Temin, 1991, Temin and Marthas, 1984, Pimpinelli and Dimitri, 1989, Palopoli et al., 1994, Palopoli and Wu, 1996, Moschetti et al., 1996, Merrill and Ganetzky, 1995, McLean et al., 1994, Powers and Ganetzky, 1991, Temin et al., 1991, Dimova et al., 2003, McElroy and McLean, 2006, McLean et al., 2008, Tanji et al., 2006, McElroy et al., 2008, Minakhina et al., 2005, Haussmann et al., 2008, Ferree and Prasad, 2012) SD (Stadler, 1996, Hurst, 1993, McDaniel et al., 2002, Lyttle, 2002, Minakhina et al., 2004, Singh, 2000, Kelly and Wade, 2000, Sergeev et al., 2001, Houtchens and Lyttle, 2003) Sd-RanGAP (McLean et al., 2008, Minakhina et al., 2005) Sd-RanGap (Presgraves et al., 2009)
Name Synonym	Ran GTPase activating protein (Minakhina et al., 2005) Segregation distorter (McLean et al., 1994, Sergeev et al., 2001, McLean et al., 2008, Dimitri et al., 2003, Presgraves et al., 2009) Segregation Distorter (Houtchens and Lyttle, 2003)
Secondary FlyBase IDs
References ( 175 )
Generate a list of	All references relating to this gene ( 175 )
List References by type	Research paper  ( 93 ) Supplementary material  ( 8 ) Review  ( 23 ) Personal communication to FlyBase  ( 11 ) Abstract  ( 25 ) FlyBase analysis  ( 3 ) Stock list  ( 1 ) Patent  ( 1 ) DNA/RNA sequence record  ( 2 ) Protein sequence record  ( 1 ) Website  ( 1 ) Conference report  ( 3 ) Curated genome annotation  ( 2 ) Book  ( 1 )
Recent research papers ( 7 )
	Fukuyama et al., 2012, J. Proteomics 75(15): 4610--4619 On-bead tryptic proteolysis: An attractive procedure for LC-MS/MS analysis of the Drosophila caspase 8 protein complex during immune response against bacteria. [FBrf0218992] Reid et al., 2012, Front. Cell. Infect. Microbiol. 2: 24 Identification of genetic modifiers of CagA-induced epithelial disruption in Drosophila. [FBrf0219288] Steiner et al., 2012, Genome Res. 22(4): 766--777 Cell-type-specific nuclei purification from whole animals for genome-wide expression and chromatin profiling. [FBrf0217906] Cesario and McKim, 2011, J. Cell Sci. 124(22): 3797--3810 RanGTP is required for meiotic spindle organization and the initiation of embryonic development in Drosophila. [FBrf0216751] Liu et al., 2011, Dev. Growth Differ. 53(6): 822--841 Negative modulation of bone morphogenetic protein signaling by Dullard during wing vein formation in Drosophila. [FBrf0214664] Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593 Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621] Schrider et al., 2011, Genome Res. 21(12): 2087--2095 Genome-wide analysis of retrogene polymorphisms in Drosophila melanogaster. [FBrf0216827] Show all research papers ...
Recent reviews ( 1 )
	Ferree and Prasad, 2012, Genet. Res. Int. 2012: 430136 How can satellite DNA divergence cause reproductive isolation? Let us count the chromosomal ways. [FBrf0218238] Show all reviews ...