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Gene Dmel\sei

General Information
Symbol	Dmel\sei	Species	D. melanogaster
Name	seizure	Annotation symbol	CG3182
Feature type	protein_coding_gene	FlyBase ID	FBgn0003353
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	erg, Derg
Genomic Location
Chromosome (arm)	2R	Recombination map	2-106
Cytogenetic map	60B5-60B6	Sequence location	2R:19,936,728..19,940,562 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene seizure is referred to in FlyBase by the symbol Dmel\sei (CG3182, FBgn0003353). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: voltage-gated potassium channel activity. It is reported to be involved in the biological process: potassium ion transport. 18 alleles are reported. The phenotypes of these alleles are annotated with: dorsal medial muscle; adult central nervous system; neuromuscular junction; adult brain. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Cyclic nucleotide-binding domain; Cyclic nucleotide-binding-like; Ion transport; Potassium channel, voltage-dependent, EAG/ELK/ERG; Potassium channel, voltage-dependent, ERG; RmlC-like jelly roll fold. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed within 00-12 hour embryonic stages, at stages throughout the pupal period, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system. Comments on Affy2 ProbeSet: ProbeSet 1629418_s_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of sei. Gene sequence location is 2R:19936728..19940562.
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	sei: seizure (J.C. Hall) Paralyzed fairly rapidly at temperatures above 38; adults seem to have a fit before becoming immobile, as opposed to immediately ceasing their movements; increasing times of exposure to high temperature leads to progressively longer times necessary for recovery when temperature is lowered (Jackson et al., 1985); sei1 is recessive for heat-sensitive paralysis (Jackson et al., 1985); sei2 is semi-dominant in this respect, and behavior of hyperploid adults exhibits dose dependence: sei2/sei2/+ flies become paralyzed, at 40, slightly less rapidly than homozygous mutants; sei2/+/+ paralyzed more slowly than sei2/+ but faster than wild-type (Jackson et al., 1985); biochemically, head membrane extracts from sei2 adults exhibit anomalously high Kd of saxitoxin (STX) binding activity, and a different pH dependence of this activity from wild-type; these abnormalities observed when the incubations done at high, but not low, temperatures (Jackson et al., 1984); in flies carrying three sei alleles, apparent reductions in the amounts of STX bound are observed, which are proportional to the relative number of mutant alleles (Jackson et al., 1985); when these kinds of biochemical experiments are performed on head extracts from sei1, Kd values are not appreciably different from wild-type at all assay temperatures, but the concentrations of STX binding activity are lower than wild-type under the influence of this allele, with such reductions being more marked at higher assay temperatures; recovery times, after exposure to high temperature and subsequent return to mild conditions, are shortened when sei2 is combined with napts (Jackson et al., 1985). Recordings of action potentials in the adult giant-fiber pathway reveal no decrement in sei2 at 40 (Nelson and Baird, 1985, Neurosci. Abstr. 11: 313); at temperatures >40, sei2 causes spontaneous activity in recordings from dorsal longitudinal flight muscles, to appear coincidentally with the heat-induced paralysis (Kasbekar et al., 1989); from "tight-seal whole-cell" recordings, using cultured neurons from sei1 embryos, this mutation found to cause sodium current density to be about half-normal; yet, voltage dependence and channel-gating properties were not different from wild type (O'Dowd and Aldrich, 1988); for other aspects of sei-associated defects in physiology, see enhancer of seizure.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Sequence features HFA04713 BKN20069
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 60B5-60B6   Limits computationally determined from genome sequence between P{lacW}Phmk07623&P{lacW}tsrk05633 and P{EP}EP503
Experimentally Determined Cytological Location
Cytogenetic map Notes References 60B1-60B2     (Titus, 1995.12.5) 60B1-60B2   (determined by in situ hybridisation)   (Titus et al., 1997)
Experimentally Determined Recombination Data
Location	2-106
Left of (cM)	sp (Germeraad et al., 1992)
Right of (cM)	bw (Germeraad et al., 1992)
Notes	Mapped by B. Ganetzky. Probably maps a short interval (<1 mu) to 2-106, inferred from cytology. (Hall, 1992)
Gene Model & Products
Please see the GBrowse view of Dmel\sei for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) sei-RA FBtr0072169  NM_057365   2718   855 sei-RB FBtr0072170  NM_166653   2754   855
Additional Transcript Data & Comments
Reported size (kB)	3.4, 3.0 (northern blot) (Wang et al., 1997) 2.8-3.0 (northern blot) (Titus et al., 1997)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein sei-PA   FBpp0072078   97.6   855   9.13     NP_476713   AAM68296 sei-PB   FBpp0072079   97.6   855   9.13     NP_726408   AAF47148
Additional Polypeptide Data & Comments
Reported size (kDa)	855 (aa); 97.5 (kD predicted) (Wang et al., 1997) 855 (aa) (Titus et al., 1997)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Cyclic nucleotide-binding-like (IPR018490) Cyclic nucleotide-binding domain (IPR000595) Potassium channel, voltage-dependent, EAG/ELK/ERG (IPR003938) Potassium channel, voltage-dependent, ERG (IPR003967) Ion transport (IPR005821) RmlC-like jelly roll fold (IPR014710)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF47148   AE013599 AAM68296   AC004642   AI134701   AY058350 AAL13579   BI170737   BI365251   BI367725   CO288088   CO305495   CO310191   EC070114   EC202041   EC226307   EC227126   U36925 AAB50936   U42204 AAB50956
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7JPB9
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage   presumptive embryonic/larval central nervous system   (Titus et al., 1997) adult stage     (Titus et al., 1997)
Additional Descriptive Data
	A single 2.8-3.0 kb sei transcript is detected in northern blots of whole adult mRNA. In situ hybridization experiments show that sei is expressed in the embryonic CNS. (Titus et al., 1997)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0003353    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0003353 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed within 00-12 hour embryonic stages, at stages throughout the pupal period, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0003353 expression level Developmental Stage   Expression Level embryo 00-02hr    494 embryo 02-04hr    145 embryo 04-06hr    374 embryo 06-08hr    404 embryo 08-10hr    296 embryo 10-12hr    178 embryo 12-14hr    224 embryo 14-16hr    214 embryo 16-18hr    269 embryo 18-20hr    229 embryo 20-22hr    229 embryo 22-24hr    290 larva L1    220 larva L2    142 larva L3 12hr old    84 larva L3 puffstage 1-2    161 larva L3 puffstage 3-6    252 larva L3 puffstage 7-9    360 white prepupae new    329 white prepupae 12hr    471 white prepupae 24hr    630 pupae 2d postWPP    593 pupae 3d postWPP    402 pupae 4d postWPP    278 adult male 01day    347 adult male 05day    339 adult male 30day    351 adult female 01day    396 adult female 05day    560 adult female 30day    538 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (494) embryo 02-04hr  (145) embryo 04-06hr  (374) embryo 06-08hr  (404) embryo 08-10hr  (296) embryo 10-12hr  (178) embryo 12-14hr  (224) embryo 14-16hr  (214) embryo 16-18hr  (269) embryo 18-20hr  (229) embryo 20-22hr  (229) embryo 22-24hr  (290) larva L1  (220) larva L2  (142) larva L3 12hr old    84 larva L3 puffstage 1-2  (161) larva L3 puffstage 3-6  (252) larva L3 puffstage 7-9  (360) white prepupae new  (329) white prepupae 12hr  (471) white prepupae 24hr  (630) pupae 2d postWPP  (593) pupae 3d postWPP  (402) pupae 4d postWPP  (278) adult male 01day  (347) adult male 05day  (339) adult male 30day  (351) adult female 01day  (396) adult female 05day  (560) adult female 30day  (538) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    494 embryo 02-04hr    145 embryo 04-06hr    374 embryo 06-08hr    404 embryo 08-10hr    296 embryo 10-12hr    178 embryo 12-14hr    224 embryo 14-16hr    214 embryo 16-18hr    269 embryo 18-20hr    229 embryo 20-22hr    229 embryo 22-24hr    290 larva L1    220 larva L2    142 larva L3 12hr old    84 larva L3 puffstage 1-2    161 larva L3 puffstage 3-6    252 larva L3 puffstage 7-9    360 white prepupae new    329 white prepupae 12hr    471 white prepupae 24hr    630 pupae 2d postWPP    593 pupae 3d postWPP    402 pupae 4d postWPP    278 adult male 01day    347 adult male 05day    339 adult male 30day    351 adult female 01day    396 adult female 05day    560 adult female 30day    538 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    494 embryo 02-04hr    145 embryo 04-06hr    374 embryo 06-08hr    404 embryo 08-10hr    296 embryo 10-12hr    178 embryo 12-14hr    224 embryo 14-16hr    214 embryo 16-18hr    269 embryo 18-20hr    229 embryo 20-22hr    229 embryo 22-24hr    290 larva L1    220 larva L2    142 larva L3 12hr old    84 larva L3 puffstage 1-2    161 larva L3 puffstage 3-6    252 larva L3 puffstage 7-9    360 white prepupae new    329 white prepupae 12hr    471 white prepupae 24hr    630 pupae 2d postWPP    593 pupae 3d postWPP    402 pupae 4d postWPP    278 adult male 01day    347 adult male 05day    339 adult male 30day    351 adult female 01day    396 adult female 05day    560 adult female 30day    538 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    494 embryo 02-04hr    145 embryo 04-06hr    374 embryo 06-08hr    404 embryo 08-10hr    296 embryo 10-12hr    178 embryo 12-14hr    224 embryo 14-16hr    214 embryo 16-18hr    269 embryo 18-20hr    229 embryo 20-22hr    229 embryo 22-24hr    290 larva L1    220 larva L2    142 larva L3 12hr old    84 larva L3 puffstage 1-2    161 larva L3 puffstage 3-6    252 larva L3 puffstage 7-9    360 white prepupae new    329 white prepupae 12hr    471 white prepupae 24hr    630 pupae 2d postWPP    593 pupae 3d postWPP    402 pupae 4d postWPP    278 adult male 01day    347 adult male 05day    339 adult male 30day    351 adult female 01day    396 adult female 05day    560 adult female 30day    538 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0003353 expression level Developmental Stage   Expression Level embryo 00-02hr    494 embryo 02-04hr    145 embryo 04-06hr    374 embryo 06-08hr    404 embryo 08-10hr    296 embryo 10-12hr    178 embryo 12-14hr    224 embryo 14-16hr    214 embryo 16-18hr    269 embryo 18-20hr    229 embryo 20-22hr    229 embryo 22-24hr    290 larva L1    220 larva L2    142 larva L3 12hr old    84 larva L3 puffstage 1-2    161 larva L3 puffstage 3-6    252 larva L3 puffstage 7-9    360 white prepupae new    329 white prepupae 12hr    471 white prepupae 24hr    630 pupae 2d postWPP    593 pupae 3d postWPP    402 pupae 4d postWPP    278 adult male 01day    347 adult male 05day    339 adult male 30day    351 adult female 01day    396 adult female 05day    560 adult female 30day    538 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (494) embryo 02-04hr  (145) embryo 04-06hr  (374) embryo 06-08hr  (404) embryo 08-10hr  (296) embryo 10-12hr  (178) embryo 12-14hr  (224) embryo 14-16hr  (214) embryo 16-18hr  (269) embryo 18-20hr  (229) embryo 20-22hr  (229) embryo 22-24hr  (290) larva L1  (220) larva L2  142 larva L3 12hr old    84 larva L3 puffstage 1-2  (161) larva L3 puffstage 3-6  (252) larva L3 puffstage 7-9  (360) white prepupae new  (329) white prepupae 12hr  (471) white prepupae 24hr  (630) pupae 2d postWPP  (593) pupae 3d postWPP  (402) pupae 4d postWPP  (278) adult male 01day  (347) adult male 05day  (339) adult male 30day  (351) adult female 01day  (396) adult female 05day  (560) adult female 30day  (538) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    494 embryo 02-04hr    145 embryo 04-06hr    374 embryo 06-08hr    404 embryo 08-10hr    296 embryo 10-12hr    178 embryo 12-14hr    224 embryo 14-16hr    214 embryo 16-18hr    269 embryo 18-20hr    229 embryo 20-22hr    229 embryo 22-24hr    290 larva L1    220 larva L2    142 larva L3 12hr old    84 larva L3 puffstage 1-2    161 larva L3 puffstage 3-6    252 larva L3 puffstage 7-9    360 white prepupae new    329 white prepupae 12hr    471 white prepupae 24hr    630 pupae 2d postWPP    593 pupae 3d postWPP    402 pupae 4d postWPP    278 adult male 01day    347 adult male 05day    339 adult male 30day    351 adult female 01day    396 adult female 05day    560 adult female 30day    538 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    494 embryo 02-04hr    145 embryo 04-06hr    374 embryo 06-08hr    404 embryo 08-10hr    296 embryo 10-12hr    178 embryo 12-14hr    224 embryo 14-16hr    214 embryo 16-18hr    269 embryo 18-20hr    229 embryo 20-22hr    229 embryo 22-24hr    290 larva L1    220 larva L2    142 larva L3 12hr old    84 larva L3 puffstage 1-2    161 larva L3 puffstage 3-6    252 larva L3 puffstage 7-9    360 white prepupae new    329 white prepupae 12hr    471 white prepupae 24hr    630 pupae 2d postWPP    593 pupae 3d postWPP    402 pupae 4d postWPP    278 adult male 01day    347 adult male 05day    339 adult male 30day    351 adult female 01day    396 adult female 05day    560 adult female 30day    538 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    494 embryo 02-04hr    145 embryo 04-06hr    374 embryo 06-08hr    404 embryo 08-10hr    296 embryo 10-12hr    178 embryo 12-14hr    224 embryo 14-16hr    214 embryo 16-18hr    269 embryo 18-20hr    229 embryo 20-22hr    229 embryo 22-24hr    290 larva L1    220 larva L2    142 larva L3 12hr old    84 larva L3 puffstage 1-2    161 larva L3 puffstage 3-6    252 larva L3 puffstage 7-9    360 white prepupae new    329 white prepupae 12hr    471 white prepupae 24hr    630 pupae 2d postWPP    593 pupae 3d postWPP    402 pupae 4d postWPP    278 adult male 01day    347 adult male 05day    339 adult male 30day    351 adult female 01day    396 adult female 05day    560 adult female 30day    538 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0003353    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0003353 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0003353 expression level Tissue   Expression Level Larval Central Nervous System    143.675 Larval Midgut    3.7 Larval Hindgut    5.3 Larval Malpighian Tubules    1.5 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    30.625 Larval Carcass no informative data Adult Head    137.4 Adult Eye    198.25 Adult Brain    453.8 Adult Thoracic-Abdominal Ganglion    466.9 Adult Crop    8.7 Adult Midgut no informative data Adult Hindgut    5.5 Adult Malpighian Tubules    4.7 Adult Fat Body    61.4 Adult Salivary Gland    7.2 Adult Heart    47.45 Adult VirginFemale Spermatheca    59 Adult InseminatedFemale Spermatheca    91.3 Adult Ovary    58.7 Adult Testis    27.7 Adult Male Accessory Gland no informative data Adult Carcass    35.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    143.675 Larval Midgut    3.7 Larval Hindgut    5.3 Larval Malpighian Tubules    1.5 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    30.625 Larval Carcass no informative data Adult Head    137.4 Adult Eye    198.25 Adult Brain    453.8 Adult Thoracic-Abdominal Ganglion    466.9 Adult Crop    8.7 Adult Midgut no informative data Adult Hindgut    5.5 Adult Malpighian Tubules    4.7 Adult Fat Body    61.4 Adult Salivary Gland    7.2 Adult Heart    47.45 Adult VirginFemale Spermatheca    59 Adult InseminatedFemale Spermatheca    91.3 Adult Ovary    58.7 Adult Testis    27.7 Adult Male Accessory Gland no informative data Adult Carcass    35.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    143.675 Larval Midgut    3.7 Larval Hindgut    5.3 Larval Malpighian Tubules    1.5 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    30.625 Larval Carcass no informative data Adult Head    137.4 Adult Eye    198.25 Adult Brain    453.8 Adult Thoracic-Abdominal Ganglion    466.9 Adult Crop    8.7 Adult Midgut no informative data Adult Hindgut    5.5 Adult Malpighian Tubules    4.7 Adult Fat Body    61.4 Adult Salivary Gland    7.2 Adult Heart    47.45 Adult VirginFemale Spermatheca    59 Adult InseminatedFemale Spermatheca    91.3 Adult Ovary    58.7 Adult Testis    27.7 Adult Male Accessory Gland no informative data Adult Carcass    35.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    143.675 Larval Midgut    3.7 Larval Hindgut    5.3 Larval Malpighian Tubules    1.5 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    30.625 Larval Carcass no informative data Adult Head    137.4 Adult Eye    198.25 Adult Brain    453.8 Adult Thoracic-Abdominal Ganglion    466.9 Adult Crop    8.7 Adult Midgut no informative data Adult Hindgut    5.5 Adult Malpighian Tubules    4.7 Adult Fat Body    61.4 Adult Salivary Gland    7.2 Adult Heart    47.45 Adult VirginFemale Spermatheca    59 Adult InseminatedFemale Spermatheca    91.3 Adult Ovary    58.7 Adult Testis    27.7 Adult Male Accessory Gland no informative data Adult Carcass    35.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0003353 expression level Tissue   Expression Level Larval Central Nervous System    143.675 Larval Midgut    3.7 Larval Hindgut    5.3 Larval Malpighian Tubules    1.5 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    30.625 Larval Carcass no informative data Adult Head    137.4 Adult Eye    198.25 Adult Brain    453.8 Adult Thoracic-Abdominal Ganglion    466.9 Adult Crop    8.7 Adult Midgut no informative data Adult Hindgut    5.5 Adult Malpighian Tubules    4.7 Adult Fat Body    61.4 Adult Salivary Gland    7.2 Adult Heart    47.45 Adult VirginFemale Spermatheca    59 Adult InseminatedFemale Spermatheca    91.3 Adult Ovary    58.7 Adult Testis    27.7 Adult Male Accessory Gland no informative data Adult Carcass    35.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    143.675 Larval Midgut    3.7 Larval Hindgut    5.3 Larval Malpighian Tubules    1.5 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    30.625 Larval Carcass no informative data Adult Head    137.4 Adult Eye    198.25 Adult Brain    453.8 Adult Thoracic-Abdominal Ganglion    466.9 Adult Crop    8.7 Adult Midgut no informative data Adult Hindgut    5.5 Adult Malpighian Tubules    4.7 Adult Fat Body    61.4 Adult Salivary Gland    7.2 Adult Heart    47.45 Adult VirginFemale Spermatheca    59 Adult InseminatedFemale Spermatheca    91.3 Adult Ovary    58.7 Adult Testis    27.7 Adult Male Accessory Gland no informative data Adult Carcass    35.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    143.675 Larval Midgut    3.7 Larval Hindgut    5.3 Larval Malpighian Tubules    1.5 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    30.625 Larval Carcass no informative data Adult Head    137.4 Adult Eye    198.25 Adult Brain    453.8 Adult Thoracic-Abdominal Ganglion    466.9 Adult Crop    8.7 Adult Midgut no informative data Adult Hindgut    5.5 Adult Malpighian Tubules    4.7 Adult Fat Body    61.4 Adult Salivary Gland    7.2 Adult Heart    47.45 Adult VirginFemale Spermatheca    59 Adult InseminatedFemale Spermatheca    91.3 Adult Ovary    58.7 Adult Testis    27.7 Adult Male Accessory Gland no informative data Adult Carcass    35.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    143.675 Larval Midgut    3.7 Larval Hindgut    5.3 Larval Malpighian Tubules    1.5 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    30.625 Larval Carcass no informative data Adult Head    137.4 Adult Eye    198.25 Adult Brain    453.8 Adult Thoracic-Abdominal Ganglion    466.9 Adult Crop    8.7 Adult Midgut no informative data Adult Hindgut    5.5 Adult Malpighian Tubules    4.7 Adult Fat Body    61.4 Adult Salivary Gland    7.2 Adult Heart    47.45 Adult VirginFemale Spermatheca    59 Adult InseminatedFemale Spermatheca    91.3 Adult Ovary    58.7 Adult Testis    27.7 Adult Male Accessory Gland no informative data Adult Carcass    35.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea     Larval Carcass no informative data Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut no informative data Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland no informative data Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    137.4   NA  Eye    198.25   NA  Brain    453.8   143.675  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    466.9   NA  Crop    8.7   3.7  Midgut    no informative data   5.3  Hindgut    5.5   1.5  Malpighian Tubules    4.7   no informative data  Fat Body    61.4   no informative data  Salivary Gland    7.2   NA  Heart    47.45   30.625  Trachea    NA   NA  VirginFemale Spermatheca    59   NA  InseminatedFemale Spermatheca    91.3   NA  Ovary    58.7   NA  Testis    27.7   NA  Male Accessory Gland    no informative data   no informative data  Carcass    35.5 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_27
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003353 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3182-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 seiGD2196 Other Phenotypes Allele behavior defective | heat sensitive sei1 neuroanatomy defective sei1 sei2 neuroanatomy defective (with sei1) sei2 neuroanatomy defective (with sei2) sei1 neuroanatomy defective | adult stage sei2 neuroanatomy defective | heat sensitive sei1 neuroanatomy defective | temperature conditional sei1 neurophysiology defective | heat sensitive sei1 sei2 paralytic | codominant | heat sensitive sei2 paralytic | heat sensitive sei1 sei2 seiG43 seiG50 seiG64 wild-type seihs.PW Phenotype manifest in Allele adult brain sei2 adult central nervous system sei1 sei2 dorsal medial muscle sei1 neuromuscular junction sei1 sei2 neuromuscular junction (with sei1) sei2 neuromuscular junction (with sei2) sei1 neuromuscular junction & synapse sei1 neuromuscular junction | heat sensitive sei1 neuromuscular junction | temperature conditional sei1 NMJ bouton | ectopic (with sei1) sei2 NMJ bouton | ectopic (with sei2) sei1 NMJ bouton | supernumerary sei1 sei2 NMJ bouton | supernumerary (with sei1) sei2 NMJ bouton | supernumerary (with sei2) sei1 NMJ bouton | supernumerary | heat sensitive sei1 NMJ bouton | temperature conditional sei1 synapse | ectopic | heat sensitive sei1
Classical Alleles ( 10 )
For All Classical Alleles Show
Allele of sei Class Mutagen Stocks Known lesion seiHP21840 1 -- sei1 loss of function allele ethyl methanesulfonate 0 Yes sei2 ethyl methanesulfonate 0 Yes seiG43 gamma ray 0 Yes seiG50 gamma ray 0 Yes seiG64 gamma ray 0 Yes seiG85 gamma ray 0 Yes seiG87 gamma ray 0 Yes seiRK3 gamma ray 0 Yes seiRK4 gamma ray 0 Yes
Alleles Carried on Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Allele of sei Class Mutagen Stocks Known lesion seiGD2196 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes seiJF01474 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes seiJF01475 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes seiKK105733 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes seihs.PW in vitro construct - regulatory fusion 0 Yes seiScer\UAS.cFa in vitro construct - regulatory fusion 0 Yes seiScer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes seits2.Scer\UAS in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel6081 (Ryder, 2004.4.26) Df(2R)or-BR6 (Wang et al., 1997) Df(2R)or-BR11 (Wang et al., 1997)
Not disrupted in	Df(2R)bw-D23 (Wang et al., 1997) Df(2R)bw-S46 (Jackson et al., 1985, Wang et al., 1997) Df(2R)Px1 (Jackson et al., 1985, Wang et al., 1997) Df(2R)spMP (Wang et al., 1997) In(2LR)ltG10LBR27R (Wang et al., 1997) In(2LR)Px4 (Wang et al., 1997)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD2196} NA P{KK105733} NA P{TRiP.JF01474} NA P{TRiP.JF01475} NA P{UAS-sei.F} NA P{UAS-sei.GFP} NA P{UAS-sei.ts2} NA heat-shock construct P{hs-sei} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPg}seiHP21840 NA
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
voltage-gated potassium channel activity inferred from electronic annotation with InterPro:IPR003938, InterPro:IPR003967 (FlyBase Curators et al., 2004-) non-traceable author statement (Littleton and Ganetzky, 2000)
Biological Process
CV term Evidence References
potassium ion transport inferred from electronic annotation with InterPro:IPR003938, InterPro:IPR003967 (FlyBase Curators et al., 2004-) non-traceable author statement (Littleton and Ganetzky, 2000) transmembrane transport inferred from electronic annotation with InterPro:IPR005821 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
membrane inferred from electronic annotation with InterPro:IPR003938, InterPro:IPR003967, InterPro:IPR005821 (FlyBase Curators et al., 2004-) voltage-gated potassium channel complex non-traceable author statement (Littleton and Ganetzky, 2000)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions sei allele Gene References unspecified e(sei) (Jackson et al., 1985)
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0003353 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37843
Orthologs
Genome-wide drosophilid orthologs	Dana\GF11362 Dere\GG22928 Dper\GL11656 Dsec\GM18295 Dsim\GD11824 Dwil\GK21385 Dyak\GE14365
Curated drosophilid orthologs
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AGAP007709-PA Anopheles gambiae (mosquito) XP_001947207.1 Acyrthosiphon pisum (pea aphid) At5g46240.1 Arabidopsis thaliana (wall cress) 21153 Batrachochytrium dendrobatidis (chytrid fungus) 243555 Branchiostoma floridae (lancelet) BGIBMGA007794-PA Bombyx mori (silk worm) ENSBTAP00000022102 Bos taurus (bovine) CBP29744 Caenorhabditis briggsae (nematode) CE41299 Caenorhabditis elegans (worm) JA05247 Caenorhabditis japonica (nematode) ENSCPOP00000001460 Cavia porcellus (guinea pig) 148683 Chlamidomonas reinhardtii (green alga) RP31964 Caenorhabditis remanei (nematode) ENSCSAVP00000005805 Ciona savignyi (sedentary tunicate) 177706 Capitella spl (polychaete worm) 39704 Daphnia pulex (daphnia) ENSDARP00000085307 Danio rerio (zebra fish) ENSECAP00000021257 Equus caballus (horse) ENSGACP00000001384 Gymnopilus aculeatus (mushroom) ENSGALP00000030828 Gallus gallus (chicken) 86941 Hypsipyla robusta (cedar shoot borer) ENSMODP00000032539 Monodelphis domestica (gray opossum) ENSMUSP00000001965 Mus musculus (house mouse) 236199 Nematostella vectensis (starlet anemone) ENSORLP00000004166 Oryzias latipes (japanese killifish) LOC_Os02g14840.1 Oryza sativa (asian rice) 20710 Ostreococcus tauri (green alga) PHUM005443-PA Pediculus humanus (human body louse) 1388 Physcomitrella patens (moss) 77922 Physcomitrella patens (moss) 74787 Phytophthora ramorum (sudden oak death pathogen) 129135 Phytophthora sojae (root rot pathogen) 414107 Populus trichocarpa (black cottonwood) ENSPTRP00000016153 Pan troglodytes (chimpanzee) ENSRNOP00000010816 Rattus norvegicus (norway rat) 144325 Sorghum bicolor (sorghum) 55030 Trichoplax adhaerens (metazoa) XP_973853.2 Tribolium castaneum (red flour beetle) ENSTNIP00000011631 Tetraodon nigroviridis (green spotted pufferfish) 2481 Thalassiosira pseudonana (marine diatom) ENSTRUP00000027499 Takifugu rubripes (pufferfish Takifugu) 342.m00027 Tetrahymena thermophila (ciliate protozoa) 3686.m00112 Tetrahymena thermophila (ciliate protozoa) 88289.m00141 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000014249 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB18104 LH15357 ISCW003234 FBgn0231976 FBgn0223377 FBgn0183563 FBgn0173202 JGI_V11_39704 FBgn0149265 FBgn0115085 FBgn0088402 CPIJ017948 BGIBMGA007794 ACYPI010128 GB18644 AGAP007709 AAEL001542 PHUM193530 GLEAN_15503
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	21935 w1118; P{EPg}seiHP21840 31682 y1 v1; P{TRiP.JF01475}attP2 31681 y1 v1; P{TRiP.JF01474}attP2/TM3, Ser1
VDRC	v104698 P{KK105733}VIE-260B v3606 w1118; P{GD2196}v3606/TM3
Genomic Clones ( 1 )
	BACR28M05 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 11 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH12235
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE12292 RE50501 RE53547
Other clones	97879 146203 165999 CK01.85C.E7 EK067720 EK220663 EK248816
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0003353 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37843
Antibody Information
Other Information
Discoverer
	Wu and Ganetzky.
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: sei CG3182 (Wang, 1999.11)
Source for database merge of
Additional comments
Other Comments
	The erg polypeptide corresponds to sei, based on sequence analysis and failure of complementation. (Titus et al., 1997) Isolation and characterisation of sei. The primary defect in sei is in a K+ channel polypeptide. (Titus et al., 1997) From 'tight-seal whole-cell' recordings, using cultured neurons from sei1 embryos, this mutation found to cause sodium current density to be about half-normal; yet, voltage dependence and channel-gating properties were not different from wild type. (O'Dowd and Aldrich, 1988) Though some of the data mentioned above suggest sei might code for a voltage-sensitive sodium-channel component, this gene could not be co-localized with a known sodium-channel-encoding factor in 2R, which on the basis of clone and sequence plus in situ hybridization, maps within 60D-E. (Salkoff et al., 1987) Paralyzed fairly rapidly at temperatures above 38oC; adults seem to have a fit before becoming immobile, as opposed to immediately ceasing their movements; increasing times of exposure to high temperature leads to progressively longer times necessary for recovery when temperature is lowered. (Jackson et al., 1985)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057365 NM_166653 RefSeq (Proteins) • NP_476713 NP_726408 DDBJ / EMBL / GenBank • AAB50936 AAB50956 AAF47148 AAL13579 AAM68296 AC004642 AI134701 AY058350 U36925 U42204 Entrez Gene - A searchable database of RefSeq genes. • 37843 UniProtKB/TrEMBL • Q7JPB9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Cyclic nucleotide-binding-like (IPR018490) Cyclic nucleotide-binding domain (IPR000595) Potassium channel, voltage-dependent, EAG/ELK/ERG (IPR003938) Potassium channel, voltage-dependent, ERG (IPR003967) Ion transport (IPR005821) RmlC-like jelly roll fold (IPR014710)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0003353 DRSC - Results from RNAi screens. • FBgn0003353 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003353 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3182-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0003353 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37843 InParanoid A subset of ortholog calls from InParanoid. • AGAP007709-PA Anopheles gambiae (mosquito) XP_001947207.1 Acyrthosiphon pisum (pea aphid) At5g46240.1 Arabidopsis thaliana (wall cress) 21153 Batrachochytrium dendrobatidis (chytrid fungus) 243555 Branchiostoma floridae (lancelet) BGIBMGA007794-PA Bombyx mori (silk worm) ENSBTAP00000022102 Bos taurus (bovine) CBP29744 Caenorhabditis briggsae (nematode) CE41299 Caenorhabditis elegans (worm) JA05247 Caenorhabditis japonica (nematode) ENSCPOP00000001460 Cavia porcellus (guinea pig) 148683 Chlamidomonas reinhardtii (green alga) RP31964 Caenorhabditis remanei (nematode) ENSCSAVP00000005805 Ciona savignyi (sedentary tunicate) 177706 Capitella spl (polychaete worm) 39704 Daphnia pulex (daphnia) ENSDARP00000085307 Danio rerio (zebra fish) ENSECAP00000021257 Equus caballus (horse) ENSGACP00000001384 Gymnopilus aculeatus (mushroom) ENSGALP00000030828 Gallus gallus (chicken) 86941 Hypsipyla robusta (cedar shoot borer) ENSMODP00000032539 Monodelphis domestica (gray opossum) ENSMUSP00000001965 Mus musculus (house mouse) 236199 Nematostella vectensis (starlet anemone) ENSORLP00000004166 Oryzias latipes (japanese killifish) LOC_Os02g14840.1 Oryza sativa (asian rice) 20710 Ostreococcus tauri (green alga) PHUM005443-PA Pediculus humanus (human body louse) 1388 Physcomitrella patens (moss) 77922 Physcomitrella patens (moss) 74787 Phytophthora ramorum (sudden oak death pathogen) 129135 Phytophthora sojae (root rot pathogen) 414107 Populus trichocarpa (black cottonwood) ENSPTRP00000016153 Pan troglodytes (chimpanzee) ENSRNOP00000010816 Rattus norvegicus (norway rat) 144325 Sorghum bicolor (sorghum) 55030 Trichoplax adhaerens (metazoa) XP_973853.2 Tribolium castaneum (red flour beetle) ENSTNIP00000011631 Tetraodon nigroviridis (green spotted pufferfish) 2481 Thalassiosira pseudonana (marine diatom) ENSTRUP00000027499 Takifugu rubripes (pufferfish Takifugu) 342.m00027 Tetrahymena thermophila (ciliate protozoa) 3686.m00112 Tetrahymena thermophila (ciliate protozoa) 88289.m00141 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000014249 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37843 modMine - Data generated by the modENCODE project. • FBgn0003353 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB18104 LH15357 ISCW003234 FBgn0231976 FBgn0223377 FBgn0183563 FBgn0173202 JGI_V11_39704 FBgn0149265 FBgn0115085 FBgn0088402 CPIJ017948 BGIBMGA007794 ACYPI010128 GB18644 AGAP007709 AAEL001542 PHUM193530 GLEAN_15503
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	CG3182 (Keleman et al., 2009.8.5, Ni et al., 2008) Derg (Massa et al., 2005, Massa et al., 2001, Massa et al., 2006) erg (Krishnan et al., 2004, Titus, 1995.12.5, Trimmer and Rhodes, 1997, Titus et al., 1997, McCormack, 2003) sei (Monier et al., 2007, Wang et al., 2004, Barber et al., 2009, Fergestad et al., 2010)
Name Synonym	eag related gene (Titus et al., 1997) seizure (Qian and Bodmer, 2009, Fergestad et al., 2010, Lee and Wu, 2010, McCormack, 2003) Seizure/HERG (Ocorr et al., 2007) seizure potassium channel (Wang, 1995.9.23)
Secondary FlyBase IDs
References ( 70 )
Generate a list of	All references relating to this gene ( 70 )
List References by type	Research paper  ( 30 ) Supplementary material  ( 2 ) Review  ( 5 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 20 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 2 ) Conference report  ( 1 ) Curated genome annotation  ( 1 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 2 )
	Fergestad et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(12): 5617--5621 A Drosophila behavioral mutant, down and out (dao), is defective in an essential regulator of Erg potassium channels. [FBrf0210402] Lee and Wu, 2010, J. Neurosci. 30(47): 15821--15833 Orchestration of stepwise synaptic growth by k+ and Ca2+ channels in Drosophila. [FBrf0212405] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...