Ser99Da, Jon99C, Serine protease 5, Ser5, Ser1
Low-frequency RNA-Seq exon junction(s) not annotated.
Apparent introns not annotated: probable artifacts due to repetitive sequence.
Gene model reviewed during 5.44
Gene model reviewed during 5.53
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Jon99Cii using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Jon99Cii in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: Jon99Cii Ser99Da
Similarity to cytologically mapped serine protease genes not checked.
Characterization of LAP genes "Lap-A" and "Lap-D" from the distribution and enzymatic activity of their proteins reveals a striking resemblance to the description of Jonah genes in 99C ("Jon99Co", "Jon99Ci", "Jon99Cii" and "Jon99Ciii") and 99F ("Jon99Fi" and "Jon99Fii") and the pattern of expression of their transcripts. At least one of the Jonah genes in 99C or 99F may correspond to "Lap-A" or "Lap-D".
Shows particularly robust cycling of transcription in adult heads, as assessed by expression analysis using high density oligonucleotide arrays with probe generated during three 12-point time course experiments over the course of 6 days.
In a sample of 79 genes with multiple introns, 33 showed significant heterogeneity in G+C content among introns of the same gene and significant positive correspondence between the intron and the third codon position G+C content within genes. These results are consistent with selection adding against preferred codons at the start of genes.
D.melanogaster is polymorphic for the number of "Jonah" genes in 99C. In the "β" arrangement, 4 copies are present; Jon99Co, Jon99Ci, Jon99Cii and Jon99Ciii, with Jon99Ci and Jon99Cii representing a tandem duplication of an approximately 1.8kb fragment. In the "α" arrangement, this 1.8kb fragment is only present in one copy ("Jon99Cαi").
One of a number of genes isolated from a cDNA library made from third instar salivary glands, but subsequently found not to be expressed in the salivary glands but instead expressed specifically and abundantly in the midgut (which resulted in contamination of the original cDNA library). This surprising discovery prompted the name "Jonah" for this family of genes, after the Biblical prophet who unexpectedly turned up in the gut.