General Information
Symbol
Dmel\sesB
Species
D. melanogaster
Name
stress-sensitive B
Annotation Symbol
CG16944
Feature Type
FlyBase ID
FBgn0003360
Gene Model Status
Stock Availability
Gene Snapshot
In progress.Contributions welcome.
Also Known As
ANT, jive, A/A-T/sesB, S12, l(1)S12
Genomic Location
Cytogenetic map
Sequence location
X:10,780,893..10,786,958 [-]
Recombination map
1-32
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
GO Summary Ribbons
Families, Domains and Molecular Function
Gene Group Membership (FlyBase)
Protein Family (UniProt, Sequence Similarities)
Belongs to the mitochondrial carrier (TC 2.A.29) family. (Q26365)
Molecular Function (see GO section for details)
Experimental Evidence
Predictions / Assertions
Summaries
Gene Group Membership
SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS -
The solute carrier family 25 (SLC25) or mitochondrial carrier family (MCF) members shuttle metabolites, nucleotides and cofactors across the inner mitochondrial membrane. (Adapted from FBrf0212481, FBrf0212949 and PMID:23266187).
UniProt Contributed Function Data
Catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane.
(UniProt, Q26365)
Phenotypic Description from the Red Book (Lindsley and Zimm 1992)
sesB (J.C. Hall)
sesB1 causes adults to be extremely sensitive to mechanical shock (Homyk and Sheppard, 1977); paralysis lasts many seconds, and recovery is slow; the mutant is also generally inactive and uncoordinated; when stimulated to jump and fly, does so abnormally for short distances; when reared at 29, after being raised at 22, sesB2 is not only stress-sensitive, but it also becomes debilitated after several bouts of induced to hopping and flying; in addition, sesB2 is heat sensitive for female sterility (after rearing at low temperature).
Gene Model and Products
Number of Transcripts
5
Number of Unique Polypeptides
2

Please see the GBrowse view of Dmel\sesB or the JBrowse view of Dmel\sesB for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.55
Gene model reviewed during 5.46
Shares 5' UTR with downstream gene.
Gene model reviewed during 5.56
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0073421
1634
299
FBtr0073423
1640
299
FBtr0073422
1747
312
FBtr0073424
1853
312
FBtr0346384
1685
299
Additional Transcript Data and Comments
Reported size (kB)
1.6, 1.2 (northern blot)
1.85, 1.1 (northern blot)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0073277
32.9
299
10.28
FBpp0073279
32.9
299
10.28
FBpp0073278
34.2
312
10.33
FBpp0073280
34.2
312
10.33
FBpp0312078
32.9
299
10.28
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

299 aa isoforms: sesB-PA, sesB-PB, sesB-PE
312 aa isoforms: sesB-PC, sesB-PD
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)
Homodimer.
(UniProt, Q26365)
Domain
The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.
(UniProt, Q26365)
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\sesB using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Gene Ontology (22 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
inferred from mutant phenotype
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from sequence or structural similarity with UniProtKB:P12235
inferred from biological aspect of ancestor with PANTHER:PTN000640051
(assigned by GO_Central )
Biological Process (19 terms)
Terms Based on Experimental Evidence (16 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
inferred from sequence or structural similarity with UniProtKB:P12235
inferred from sequence or structural similarity with UniProtKB:P12235
inferred from electronic annotation with InterPro:IPR002067, InterPro:IPR002113
(assigned by InterPro )
Cellular Component (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
inferred from direct assay
(assigned by UniProt )
inferred from high throughput direct assay
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from sequence or structural similarity with UniProtKB:P12235
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: maternally deposited

northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Isoform-specific expression of sesB was observed. The shorter isoform (sesB-PA, sesB-PB, and sesB-PE) is detected in testis, midgut, head, and ovary by RT-PCR. The longer isoform (sesB-PC and sesB-PD) is not detected in Malphigian tubules and is almost specific to ovary.
sesB transcripts are detected in adult RNA on northern blots.
Both sesB transcripts are detected in RNA from Kc cells and 8-24 hr embryos.
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
sesB localizes to mitochondria in Malpighian tubule principal cells.
Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
(assigned by UniProt )
inferred from high throughput direct assay
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\sesB in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 34 )
For All Classical and Insertion Alleles Show
 
Allele of sesB
Class
Mutagen
Associated Insertion
Stocks
Known lesion
Other relevant insertions
insertion of mobile activating element
Name
Expression Data
miscellaneous insertions
Name
Expression Data
Transgenic Constructs ( 13 )
Deletions and Duplications ( 62 )
Disrupted in
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (7)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
13 of 15
Yes
Yes
11 of 15
No
Yes
 
11 of 15
No
Yes
 
9 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (6)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
13 of 15
Yes
Yes
10 of 15
No
Yes
9 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Rattus norvegicus (Norway rat) (6)
11 of 13
Yes
Yes
10 of 13
No
Yes
5 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (3)
11 of 12
Yes
Yes
9 of 12
No
Yes
1 of 12
No
No
Danio rerio (Zebrafish) (7)
13 of 15
Yes
Yes
11 of 15
No
Yes
11 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (10)
12 of 15
Yes
No
12 of 15
Yes
No
11 of 15
No
No
10 of 15
No
No
6 of 15
No
Yes
6 of 15
No
Yes
4 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (5)
8 of 9
Yes
Yes
8 of 9
Yes
Yes
8 of 9
Yes
Yes
7 of 9
No
Yes
3 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (5)
14 of 15
Yes
Yes
12 of 15
No
Yes
11 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (1)
11 of 12
Yes
Yes
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190CF6 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091507YC )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Aedes aegypti
Yellow fever mosquito
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles darlingi
American malaria mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Anopheles gambiae
Malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Culex quinquefasciatus
Southern house mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0A29 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bombyx mori
Silkmoth
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Danaus plexippus
Monarch butterfly
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Heliconius melpomene
Postman butterfly
Heliconius melpomene
Postman butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis florea
Little honeybee
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Apis mellifera
Western honey bee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus impatiens
Common eastern bumble bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Bombus terrestris
Buff-tailed bumblebee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Tribolium castaneum
Red flour beetle
Tribolium castaneum
Red flour beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Pediculus humanus
Human body louse
Pediculus humanus
Human body louse
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X09XY )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0ULB )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Human Disease Model Data
FlyBase Human Disease Model Reports
Alleles Reported to Model Human Disease (Disease Ontology)
Download
Models ( 1 )
Allele
Disease
Evidence
References
inferred from mutant phenotype
Interactions ( 0 )
Allele
Disease
Interaction
References
Comments ( 0 )
 
Human Orthologs (via DIOPT v7.1)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
Summary of Genetic Interactions
esyN Network Diagram
esyN Network Key:
Suppression
Enhancement

Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
External Data
Subunit Structure (UniProtKB)
Homodimer.
(UniProt, Q26365 )
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
Pathways
Gene Group - Pathway Membership (FlyBase)
External Data
Linkouts
Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
Genomic Location and Detailed Mapping Data
Chromosome (arm)
X
Recombination map
1-32
Cytogenetic map
Sequence location
X:10,780,893..10,786,958 [-]
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
9E10-9F1
Limits computationally determined from genome sequence between P{EP}Atg8aEP362&P{EP}CG1826EP1098 and P{EP}sesBEP319&P{EP}ImpEP760
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
9F-9F
(determined by in situ hybridisation) 9E7--8 (determined by in situ hybridisation) 9F1--2 (determined by in situ hybridisation)
9F-9F
(determined by in situ hybridisation) 9E7--8 (determined by in situ hybridisation) 9F1--2 (determined by in situ hybridisation) 9E4--8 (determined by in situ hybridisation)
9E-9E
(determined by in situ hybridisation)
Immediately proximal to the distal breakpoint of In(1)AB.
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Mapped by Homyk.
Stocks and Reagents
Stocks (22)
Genomic Clones (7)
 

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (628)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences
Other clones
Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)
Other clones
RNAi and Array Information
Linkouts
DRSC - Results frm RNAi screens
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
Antibody Information
Laboratory Generated Antibodies
 
Commercially Available Antibodies
 
Other Information
Relationship to Other Genes
Source for database identify of
Source for identity of: sesB CG16944
Source for identity of: sesB orangi
Source for database merge of
Source for merge of: sesB anon-WO02059370.55
Additional comments
The genes sesB and Ant2 share >70% identity and close proximity, and so may have been derived from a DNA-based tandem duplication.
Source for merge of sesB anon-WO02059370.55 was sequence comparison ( date:051113 ).
"l(1)G0083" may affect "Ant2" and/or "sesB".
sesB and Ant2 do not correspond to Hmr.
Lack of complementation of lethal alleles and sesB alleles reported by Zhimulev et al. (FBrf0045718). Janca et al. (FBrf0044450) report lack of full complementation between sesB3 and sesB alleles.
Other Comments
sesB is a negative regulator of starvation-induced autophagic flux during oogenesis.
Identification: as a modifier of a temperature-sensitive paralytic mutation of shi.
sesB mutants enhance the temperature sensitive paralytic defect in shi mutants.
The adjacent genes sesB and Ant2, which encode adenine nucleotide translocases, are transcribed from a common promoter and their mRNAs are produced by differential splicing of a dicistronic primary transcript. Overall orientation not stated: Ant2+ = sesB+ Ant2+
Encodes the Adenine nucleotide (ADP/ATP) translocase of the inner mitochondrial membrane.
Most mutant alleles are lethal, but some show a stress-sensitive paralytic phenotype.
Claimed that Hmr encodes the adenine nucleotide translocase, but this is in error.
Origin and Etymology
Discoverer
Homyk.
Etymology
Identification
External Crossreferences and Linkouts ( 72 )
Sequence Crossreferences
NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
Other crossreferences
Linkouts
BioGRID - A database of protein and genetic interactions.
Drosophila Genomics Resource Center - Drosophila Genomics Resource Center cDNA clones
DPiM - Drosophila Protein interaction map
DroID - A comprehensive database of gene and protein interactions.
DRSC - Results frm RNAi screens
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
FlyMine - An integrated database for Drosophila genomics
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
KEGG Genes - Molecular building blocks of life in the genomic space.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
modMine - A data warehouse for the modENCODE project
Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
Synonyms and Secondary IDs (36)
Reported As
Symbol Synonym
A/A-T
ADP/ATP translocase
anon-WO02059370.55
l(1)9Ed
l(1)9Fa
l(1)DC701
l(1)EM31
l(1)G0126
l(1)G0247
l(1)G0386
Name Synonyms
Secondary FlyBase IDs
  • FBgn0001474
  • FBgn0001601
  • FBgn0001665
  • FBgn0005428
  • FBgn0005676
  • FBgn0027300
  • FBgn0028338
  • FBgn0040166
  • FBgn0064129
  • FBgn0066004
Datasets (0)
Study focus (0)
Experimental Role
Project
Project Type
Title
References (161)