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Gene Dmel\sgg

General Information
Symbol	Dmel\sgg	Species	D. melanogaster
Name	shaggy	Annotation symbol	CG2621
Feature type	protein_coding_gene	FlyBase ID	FBgn0003371
Gene Model Status	Current	Stock availability	59 publicly available
Also Known As	Zw3, GSK3, GSK3β, GSK-3β, zw-3, l(1)zw3, GSK-3, sgg-zw3, zw3sgg, EG:155E2.3
Genomic Location
Chromosome (arm)	X	Recombination map	1-1.3
Cytogenetic map	3A8-3B1	Sequence location	X:2,527,985..2,571,879 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene shaggy is referred to in FlyBase by the symbol Dmel\sgg (CG2621, FBgn0003371). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; protein kinase activity; kinase activity. There is experimental evidence for 26 unique biological process terms, many of which group under: biological regulation; single-organism developmental process; cellular component organization or biogenesis; regulation of developmental process; learning or memory; cell cycle; response to stimulus; multicellular organism reproduction; macromolecule modification; larval chitin-based cuticle development; associative learning; response to drug; post-embryonic organ morphogenesis; sensory organ development; rhythmic process. 169 alleles are reported. The phenotypes of these alleles are annotated with: organ system; organ system subdivision; adult segment; acellular anatomical structure; larval abdominal segment; thoracic segment; external compound sense organ; appendage segment; portion of tissue; imaginal precursor; peripheral nervous system. It has 17 annotated transcripts and 17 annotated polypeptides. Protein features are: Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine- / dual specificity protein kinase, catalytic domain; Serine/threonine-protein kinase, active site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult eye, adult central nervous system, larval hindgut, larval/adult Malpighian tubules, adult fat body, adult salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval central nervous system, adult crop, larval/adult midgut, adult hindgut, adult heart, larval fat body, larval salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval/adult carcass. Gene sequence location is X:2527985..2571879.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	sgg: shaggy Larval growth protracted, ceasing in the first [sgg2, sgg9], second [sgg5], or third [sgg3 and sgg10] larval instar; death follows. sgg10 may survive to puparium formation. Mutant cuticle tissue survives only in tergites; lacks bristles and appears etched; some deformed mutant wing tissue also observed in sgg3. sgg3, but no other allele produces viable and fertile males in combination with Dp(1;4)wm65g (Shannon, Kaufman, Shen, and Judd, 1972, Genetics 72: 615-38). sgg1 and sgg10 males exhibiting maternal-zygotic interaction with Dp(1;4)mg display deletion-mirror-image duplication homeotic transformation (eye-antenna, wing, and leg discs) (Robbins, 1983, Genetics 103: 633-48). Same noted in male tissue of gynandromorphs (Kaufman), sgg9, and sgg10 (Garcia-Bellido and Robbins, 1983, Genetics 103: 235-47). More recent studies with sgg32, an amorphic allele, (Bourouis et al.; Ripoll et al.; Simpson et al.; Simpson and Carteret) indicate that sgg is involved in the developmental choice between the epidermal pathway and that of the nervous system. In homozygous clones of sgg32 formed 48 h or more before puparium formation all trichomes are replaced by chaetae in the ratio of one chaeta to four trichomes reflecting the number of cells involved in the elaboration of each structure; chaetae formed conform to positional information and genotype; e.g., wing clones resemble dorsal or ventral costal bristles or triple or double row bristles depending on their position; clones are linear when near the margins and form clumps of chaetae when distant from the margins; adventitious veins often formed in association with wing clones. In the notum scutellar clones form macrochaetae in + but not sc genotypes and microchaetae in h but not + genotypes. Clones formed later than 48 h before puparium formation form trichomes, either more densely than normal (10-21 trichomes) or in normal density (up to 10 trichomes). sgg embryos from homozygous sgg female germ line cells exhibit delayed and disordered cellularization at blastoderm; gastrulation does not occur; no differentiation of ectoderm, mesoderm, or endoderm occurs; cell division continues and the embryo becomes filled with small round cells, most or all of which stain with neuronal-specific antibodies. sgg+ embryos from sgg female germinal tissue show nearly normal blastoderm formation and gastrulation; however they are short with complete cuticles and neural hyperplasia as seen in neurogenic mutants; a lawn of hairs is seen dorsally, and ventrally most of the denticle belts are lacking. Two doses of sgg+ in such embryos lead to more nearly normal cuticular development, but with odd-numbered denticle bands appearing before even-numbered ones. sgg progeny of females that carry sgg+ in their germ lines die as defective larvae with underdeveloped central nervous systems; the degree of CNS development is positively correlated with the number of maternal doses of sgg+.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03	Controlled Vocabulary Terms positive regulation of protein catabolic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process
FB2013_02	Controlled Vocabulary Terms positive regulation of mitotic metaphase/anaphase transition spindle organization nucleoplasm
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 3A8-3B1   Limits computationally determined from genome sequence between P{EP}eghEP804 and P{EP}sggEP1576
Experimentally Determined Cytological Location
Cytogenetic map Notes References 3B1-3B2   (determined by in situ hybridisation) 3A8--10 (determined by in situ hybridisation) 3B1--2 (determined by in situ hybridisation)   (Peter et al., 2002) 3A8-3A10   (determined by in situ hybridisation)   (Schaefer et al., 1999.12.10) 3B1-3B2   (determined by in situ hybridisation)   (Schaefer et al., 1999.8.12) 3B1-3B2   (determined by in situ hybridisation)   (Schaefer et al., 1999.6.15) 3B1-3B2   (determined by in situ hybridisation)   (Schaefer et al., 1999.3.29) 3B1-3B1   (determined by in situ hybridisation)   (Ruel et al., 1993) 3B1-3B1   (determined by in situ hybridisation)   (Siegfried et al., 1990) 3B1-3B1   (determined by in situ hybridisation)   (Bourouis et al., 1990)
Experimentally Determined Recombination Data
Location	1-1.3
Left of (cM)	l(1)3Bb l(1)3Bc (Judd et al., 1972)
Right of (cM)	l(1)3Ah (Judd et al., 1972)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\sgg for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters. Low-frequency RNA-seq exon junction(s) not annotated. Annotated transcripts do not represent all supported alternative splices within 5' UTR. Gene model reviewed during 5.45
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) sgg-RA FBtr0070467  NM_057366   2929   575 sgg-RB FBtr0070466  NM_057367   2847   514 sgg-RC FBtr0070470  NM_134278   3110   514 sgg-RD FBtr0070471  NM_057368   4805   1067 sgg-RE FBtr0070468  NM_166947   3055   514 sgg-RF FBtr0070469  NM_166948   3208   514 sgg-RG FBtr0070475  NM_206612   3174   496 sgg-RH FBtr0070472  NM_206615   3021   514 sgg-RI FBtr0070473  NM_206614   3091   514 sgg-RJ FBtr0070474  NM_206613   3218   575 sgg-RK FBtr0070476  NM_206611   2745   416 sgg-RM FBtr0112828  NM_001103400   2903   772 sgg-RN FBtr0301966  NM_001169178   3182   416 sgg-RO FBtr0302185  NM_001169179   2166   441 sgg-RP FBtr0331751  NM_001272263   4750   1126 sgg-RQ FBtr0331752  NM_001272264   4499   1168 sgg-RR FBtr0331753  NM_001042794   3034   597
Additional Transcript Data & Comments
Reported size (kB)	6.3, 6.1, 5.2, 4.8, 4.3, 3.4, 2.9, 2.6, 2.5, 0.5 (northern blot); 2.7 (longest cDNA) (Ruel et al., 1993) 6.1, 5.2, 4.3, 3.4, 2.6, 2.5, 0.5 (northern blot) (Bourouis et al., 1990) 2.5 (northern blot); 3.7 (longest cDNA) (Siegfried et al., 1990)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein sgg-PA   FBpp0070450   58.8   575   8.20     NP_476714   AAN09082 sgg-PB   FBpp0070449   53.9   514   8.96     NP_476715   AAN09083 sgg-PC   FBpp0070453   53.9   514   8.96     NP_599105   AAN09084 sgg-PD   FBpp0070454   114.4   1067   5.58     NP_476716   AAF45801 sgg-PE   FBpp0070451   53.9   514   8.96     NP_726822   AAN09085 sgg-PF   FBpp0070452   53.9   514   8.96     NP_726823   AAN09086 sgg-PG   FBpp0089160   52.1   496   8.61     NP_996335   AAS65255 sgg-PH   FBpp0089162   53.9   514   8.96     NP_996338   AAS65253 sgg-PI   FBpp0089158   53.9   514   8.96     NP_996337   AAS65254 sgg-PJ   FBpp0089159   58.8   575   8.20     NP_996336   AAS65252 sgg-PK   FBpp0089161   43.3   416   8.12     NP_996334   AAS65256 sgg-PM   FBpp0111741   78.1   772   9.29     NP_001096870   ABW09331 sgg-PN   FBpp0291178   43.3   416   8.12     NP_001162649   ACZ95186 sgg-PO   FBpp0291395   46.2   441   9.21     NP_001162650   ACZ95187 sgg-PP   FBpp0304139   121.2   1126   5.83     NP_001259192   AGB95038 sgg-PQ   FBpp0304140   123.8   1168   5.27     NP_001259193   AGB95039 sgg-PR   FBpp0304141   61.5   597   7.27     NP_001036259   ABI30966
Additional Polypeptide Data & Comments
Reported size (kDa)	1067, 575, 514 (aa); 100, 56 (kD observed); 114, 59, 54 (kD predicted) (Ruel et al., 1993) 514 (aa); 54 (kD predicted) (Bourouis et al., 1990) 496 (aa) (Siegfried et al., 1992) 58, 51, 47 (kD) (Ruel et al., 1993)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Serine/threonine- / dual specificity protein kinase, catalytic domain (IPR002290) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202855   AA246276   AA263317   AA390526   AA390833   AA391659   AA391706   AA536355   AA539086   AA539153   AA539192   AA539605   AA540812   AA801629   AA816491   AA820104   AA940768   AA950132   AA951516   AE014298 AAF45801   AE014298 AAN09082   AE014298 AAN09083   AE014298 AAN09084   AE014298 AAN09085   AE014298 AAN09086   AE014298 AAS65252   AE014298 AAS65253   AE014298 AAS65254   AE014298 AAS65255   AE014298 AAS65256   AE014298 ABI30966   AE014298 ABW09331   AE014298 ACZ95186   AE014298 ACZ95187   AF404349 AAQ03098   AF404350 AAQ03099   AF404351 AAQ03100   AF404352 AAQ03101   AF404353 AAQ03102   AF404354 AAQ03103   AF404355 AAQ03104   AF404356 AAQ03105   AF404357 AAQ03106   AF404358 AAQ03107   AF404359 AAQ03108   AF404360 AAQ03109   AF404361 AAQ03110   AF404362 AAQ03111   AF404363 AAQ03112   AF404364 AAQ03113   AF404365 AAQ03114   AF404366 AAQ03115   AF404367 AAQ03116   AF404368 AAQ03117   AF404369 AAQ03118   AF404370 AAQ03119   AF404371 AAQ03120   AF404372 AAQ03121   AF404373 AAQ03122   AF404374 AAQ03123   AF404375 AAQ03124   AF404376 AAQ03125   AF404377 AAQ03126   AF404378 AAQ03127   AF404379 AAQ03128   AF404380 AAQ03129   AF404381 AAQ03130   AF404382 AAQ03131   AF404383 AAQ03132   AF404384 AAQ03133   AF404385 AAQ03134   AF404386 AAQ03135   AF404387 AAQ03136   AF404388 AAQ03137   AF404389 AAQ03138   AF404390 AAQ03139   AF404391 AAQ03140   AF404392 AAQ03141   AF404393 AAQ03142   AF404394 AAQ03143   AF404395 AAQ03144   AF404396 AAQ03145   AF404398 AAQ03146   AF404399 AAQ03147   AF404400 AAQ03148   AF404401 AAQ03149   AF404402 AAQ03150   AE014298 AGB95038   AE014298 AGB95039   AI108204   AI258937   AI259081   AI293222   AI455048   AI512518   AI512665   AI512707   AI518068   AI534025   AI534620   AI542875   AJ300061   AJ300062   AJ300063   AJ300064   AL024485 CAA19676   AL034544 CAA22520   AL121804 CAB65860   AL121804 CAB72296   AQ025509   AW943733   AW944593   AX777400   AY119664 AAM50318   AY122193 AAM52705   BE978814   BF495429   BG632349   BG637903   BH901065   BI164723   BI168376   BI170077   BI212222   BI213123   BI216341   BI239013   BI354391   BI370335   BI370528   BI371075   BI376182   BI578825   BI580097   BI617284   BI638985   BP550217   BT029725   BT050474   BT072831   BT120343   BT122193   BT125899   BT133153   CA806155   CK658094   CK661640   CO187391   CO187504   CO188343   CO188368   CO188409   CO188814   CO261870   CO263618   CO264186   CO265017   CO265750   CO266730   CO268108   CO268153   CO268690   CO268702   CO269514   CO270682   CO271808   CO272692   CO272887   CO273089   CO275070   CO280279   CO284585   CO286657   CO286964   CO289016   CO290628   CO290648   CO296218   CO297102   CO297853   CO299876   CO301753   CO305328   CO306177   CO306409   CO308746   CO309087   CO314835   CO316942   CO317018   CO317852   CO320058   CO320294   CO322050   CO322236   CO326084   CO327151   CO328478   CO331177   CO340202   CO340214   CO340883   CO341285   CO342082   CO343042   CZ471595   CZ473480   CZ473541   CZ473542   CZ473738   CZ473875   CZ475881   CZ477131   CZ482934   CZ490127   DQ440045   EC052860   EC053347   EC053508   EC054837   EC055991   EC056287   EC057588   EC059681   EC060368   EC060369   EC068267   EC068432   EC069077   EC069160   EC071107   EC071372   EC071899   EC073072   EC074506   EC076085   EC076229   EC076749   EC076795   EC077293   EC077882   EC078633   EC079697   EC079982   EC082396   EC082470   EC082511   EC086706   EC089204   EC089450   EC089490   EC091079   EC091080   EC194398   EC196456   EC197122   EC197343   EC197647   EC201204   EC203516   EC205689   EC207314   EC207848   EC208010   EC209241   EC209273   EC210249   EC211811   EC214026   EC215059   EC217209   EC218389   EC221216   EC221336   EC223717   EC224847   EC225873   EC226947   EC228666   EC228711   EC229206   EC234363   EC239141   EC240287   EC240857   EC243348   EC246270   EC247399   EC248784   EC249332   EC251918   EC252115   EC253333   EC254969   EC255426   EC258262   EC260302   EC267307   EL883351   EV596030   GH941436   GH942905   GH942992   GH943011   GH943243   GH943245   GH943435   GH943599   GH944801   GH944817   GH945173   GH945219   GH945295   GH945790   GH946920   GH947162   GH947327   GH947440   GH948502   GH948726   GH948890   GH948912   GH949009   GH949143   GH950353   GH950662   GH951319   GH951448   GH951587   GH951697   GH952036   GH952071   GH952329   GH953327   GH953812   GH953852   GH954461   GH954566   GH954742   GH954916   GH954944   GH955151   GH955864   GH956157   GH956162   GH956252   GH956278   GH956418   GH956725   GH957189   GH957539   GH958328   GH958486   GH959070   GH960153   GH960367   GH960845   GH960893   GH961806   GH962194   GH962492   GH962510   GH962650   GH962939   GH963082   GH963318   GH963344   GH963662   GH963744   GH964144   GH964570   GH964778   GH965133   GH965663   GH966001   GH966394   GH966657   GH966896   GH967032   GH967204   GH967373   GH968013   GH968169   GH968451   GH969281   GH969300   GH969499   GH969654   GH969964   GH970453   GH971170   GH972211   GH972228   GH972293   GH972516   GH972595   GH973020   GH973310   GH973414   GH973772   GH973970   GH974251   GH974494   GH974567   GH974722   GH974747   GH974769   GH975231   GH975493   GH975569   GH975885   GH975960   GH976043   GH976660   GH976901   GH977040   GH977219   GH978254   GH979012   GH979360   GH979391   GH979836   GH980357   GH980390   GH980743   GH981184   GH981498   GH982077   GH982757   GH983376   GH983777   GH983783   GH983957   GH984047   GH984099   GH984156   GH984607   GH984888   GH984891   GH984909   GH985003   X53332 CAA37419   X54005 CAA37951   X54006 CAA37952   X70862 CAA50212   X70863 CAA50213   X70864 CAA50214   X70865 CAA50215   X70866 CAA50216
UniProtKB/Swiss-Prot	P18431
UniProtKB/TrEMBL	A4V3W2 A4V3W1 Q7KVY5 A8JUV9 C0PUX5 Q6A4T7 Q6A4T5 Q0KHW6 Q6A4W4 Q6A4R5 Q6A4R8 Q6A4S5 Q6A4W6
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | intense & ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   organism | ubiquitous   (Fisher et al., 2012) radioisotope in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 17   organism | ubiquitous & uniform   (Siegfried et al., 1990) embryonic stage 6 -- 8   endoderm | ubiquitous & uniform   (Siegfried et al., 1990) mesoderm | ubiquitous & uniform   (Siegfried et al., 1990) ectoderm | ubiquitous & uniform   (Siegfried et al., 1990)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference third instar larval stage   nerve terminal | subset   (Packard et al., 2002)
Additional Descriptive Data
	sgg protein was enriched in glutamatergic type 1b presynaptic terminals at the larval neuromuscular junction. (Packard et al., 2002) The 514aa sgg protein is the major form of the protein which is detected at essentially all stages of the life cycle. (Ruel et al., 1993)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
centrosome inferred from direct assay (Wojcik, 2008) inferred from direct assay (assigned by UniProtKB) (Bobinnec et al., 2006) cytoplasm inferred from direct assay (Wojcik, 2008) inferred from direct assay (assigned by UniProtKB) (Zhang et al., 2005) female germline ring canal inferred from direct assay (assigned by UniProtKB) (Bobinnec et al., 2006) fusome inferred from direct assay (Lighthouse et al., 2008) mitotic spindle inferred from direct assay (Wojcik, 2008) inferred from direct assay (assigned by UniProtKB) (Bobinnec et al., 2006) nucleoplasm inferred from direct assay (Wojcik, 2008) nucleus inferred from direct assay (Wojcik, 2008) inferred from direct assay (assigned by UniProtKB) (Zhang et al., 2005, Bobinnec et al., 2006)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult eye, adult central nervous system, larval hindgut, larval/adult Malpighian tubules, adult fat body, adult salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval central nervous system, adult crop, larval/adult midgut, adult hindgut, adult heart, larval fat body, larval salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    21 central nervous system, larvae L3    29 central nervous system, pupae P8    50 head, virgin 1-day female    39 head, virgin 4-day female    40 head, virgin 20-day female    18 head, mated 1-day female    44 head, mated 4-day female    39 head, mated 20-day female    20 head, mated 1-day male    54 head, mated 4-day male    60 head, mated 20-day male    48 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    76 digestive system, larvae L3 wandering    54 digestive system, 1-day adult    16 digestive system, 4-day adult    28 digestive system, 20-day adult    15 fat body, larvae L3 wandering    26 fat body, white prepupae    65 fat body, pupae P8    33 carcass, larvae L3 wandering    36 carcass, 1-day adult    31 carcass, 4-day adult    28 carcass, 20-day adult    21 ovary, virgin 4-day female    17 ovary, mated 4-day female    15 testis, mated 4-day male    8 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    21 central nervous system, larvae L3  (29) central nervous system, pupae P8  (50) head, virgin 1-day female  (39) head, virgin 4-day female  (40) head, virgin 20-day female    18 head, mated 1-day female  (44) head, mated 4-day female  (39) head, mated 20-day female    20 head, mated 1-day male  (54) head, mated 4-day male  (60) head, mated 20-day male  (48) salivary gland, larvae L3 wandering    8 salivary gland, white prepupae  (76) digestive system, larvae L3 wandering  (54) digestive system, 1-day adult    16 digestive system, 4-day adult  (28) digestive system, 20-day adult    15 fat body, larvae L3 wandering  26 fat body, white prepupae  (65) fat body, pupae P8  (33) carcass, larvae L3 wandering  (36) carcass, 1-day adult  (31) carcass, 4-day adult  (28) carcass, 20-day adult    21 ovary, virgin 4-day female    17 ovary, mated 4-day female    15 testis, mated 4-day male    8 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    21 central nervous system, larvae L3    29 central nervous system, pupae P8    50 head, virgin 1-day female    39 head, virgin 4-day female    40 head, virgin 20-day female    18 head, mated 1-day female    44 head, mated 4-day female    39 head, mated 20-day female    20 head, mated 1-day male    54 head, mated 4-day male    60 head, mated 20-day male    48 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    76 digestive system, larvae L3 wandering    54 digestive system, 1-day adult    16 digestive system, 4-day adult    28 digestive system, 20-day adult    15 fat body, larvae L3 wandering    26 fat body, white prepupae    65 fat body, pupae P8    33 carcass, larvae L3 wandering    36 carcass, 1-day adult    31 carcass, 4-day adult    28 carcass, 20-day adult    21 ovary, virgin 4-day female    17 ovary, mated 4-day female    15 testis, mated 4-day male    8 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    21 central nervous system, larvae L3    29 central nervous system, pupae P8    50 head, virgin 1-day female    39 head, virgin 4-day female    40 head, virgin 20-day female    18 head, mated 1-day female    44 head, mated 4-day female    39 head, mated 20-day female    20 head, mated 1-day male    54 head, mated 4-day male    60 head, mated 20-day male    48 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    76 digestive system, larvae L3 wandering    54 digestive system, 1-day adult    16 digestive system, 4-day adult    28 digestive system, 20-day adult    15 fat body, larvae L3 wandering    26 fat body, white prepupae    65 fat body, pupae P8    33 carcass, larvae L3 wandering    36 carcass, 1-day adult    31 carcass, 4-day adult    28 carcass, 20-day adult    21 ovary, virgin 4-day female    17 ovary, mated 4-day female    15 testis, mated 4-day male    8 accessory gland, mated 4-day male    7 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    21 central nervous system, larvae L3    29 central nervous system, pupae P8    50 head, virgin 1-day female    39 head, virgin 4-day female    40 head, virgin 20-day female    18 head, mated 1-day female    44 head, mated 4-day female    39 head, mated 20-day female    20 head, mated 1-day male    54 head, mated 4-day male    60 head, mated 20-day male    48 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    76 digestive system, larvae L3 wandering    54 digestive system, 1-day adult    16 digestive system, 4-day adult    28 digestive system, 20-day adult    15 fat body, larvae L3 wandering    26 fat body, white prepupae    65 fat body, pupae P8    33 carcass, larvae L3 wandering    36 carcass, 1-day adult    31 carcass, 4-day adult    28 carcass, 20-day adult    21 ovary, virgin 4-day female    17 ovary, mated 4-day female    15 testis, mated 4-day male    8 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    21 central nervous system, larvae L3  29 central nervous system, pupae P8  (50) head, virgin 1-day female  (39) head, virgin 4-day female  (40) head, virgin 20-day female    18 head, mated 1-day female  (44) head, mated 4-day female  (39) head, mated 20-day female    20 head, mated 1-day male  (54) head, mated 4-day male  (60) head, mated 20-day male  (48) salivary gland, larvae L3 wandering    8 salivary gland, white prepupae  (76) digestive system, larvae L3 wandering  (54) digestive system, 1-day adult    16 digestive system, 4-day adult  28 digestive system, 20-day adult    15 fat body, larvae L3 wandering  26 fat body, white prepupae  (65) fat body, pupae P8  (33) carcass, larvae L3 wandering  (36) carcass, 1-day adult  31 carcass, 4-day adult  28 carcass, 20-day adult    21 ovary, virgin 4-day female    17 ovary, mated 4-day female    15 testis, mated 4-day male    8 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    21 central nervous system, larvae L3    29 central nervous system, pupae P8    50 head, virgin 1-day female    39 head, virgin 4-day female    40 head, virgin 20-day female    18 head, mated 1-day female    44 head, mated 4-day female    39 head, mated 20-day female    20 head, mated 1-day male    54 head, mated 4-day male    60 head, mated 20-day male    48 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    76 digestive system, larvae L3 wandering    54 digestive system, 1-day adult    16 digestive system, 4-day adult    28 digestive system, 20-day adult    15 fat body, larvae L3 wandering    26 fat body, white prepupae    65 fat body, pupae P8    33 carcass, larvae L3 wandering    36 carcass, 1-day adult    31 carcass, 4-day adult    28 carcass, 20-day adult    21 ovary, virgin 4-day female    17 ovary, mated 4-day female    15 testis, mated 4-day male    8 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    21 central nervous system, larvae L3    29 central nervous system, pupae P8    50 head, virgin 1-day female    39 head, virgin 4-day female    40 head, virgin 20-day female    18 head, mated 1-day female    44 head, mated 4-day female    39 head, mated 20-day female    20 head, mated 1-day male    54 head, mated 4-day male    60 head, mated 20-day male    48 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    76 digestive system, larvae L3 wandering    54 digestive system, 1-day adult    16 digestive system, 4-day adult    28 digestive system, 20-day adult    15 fat body, larvae L3 wandering    26 fat body, white prepupae    65 fat body, pupae P8    33 carcass, larvae L3 wandering    36 carcass, 1-day adult    31 carcass, 4-day adult    28 carcass, 20-day adult    21 ovary, virgin 4-day female    17 ovary, mated 4-day female    15 testis, mated 4-day male    8 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    23 embryo 02-04hr    36 embryo 04-06hr    29 embryo 06-08hr    31 embryo 08-10hr    30 embryo 10-12hr    27 embryo 12-14hr    29 embryo 14-16hr    30 embryo 16-18hr    32 embryo 18-20hr    26 embryo 20-22hr    24 embryo 22-24hr    23 larva L1    16 larva L2    14 larva L3 12hr old    12 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9    33 white prepupae new    49 white prepupae 12hr    29 white prepupae 24hr    25 pupae 2d postWPP    24 pupae 3d postWPP    34 pupae 4d postWPP    27 adult male 01day    24 adult male 05day    21 adult male 30day    18 adult female 01day    17 adult female 05day    17 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    23 embryo 02-04hr  (36) embryo 04-06hr  (29) embryo 06-08hr  (31) embryo 08-10hr  (30) embryo 10-12hr  (27) embryo 12-14hr  (29) embryo 14-16hr  (30) embryo 16-18hr  (32) embryo 18-20hr  26 embryo 20-22hr    24 embryo 22-24hr    23 larva L1    16 larva L2    14 larva L3 12hr old    12 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9  (33) white prepupae new  (49) white prepupae 12hr  (29) white prepupae 24hr    25 pupae 2d postWPP    24 pupae 3d postWPP  (34) pupae 4d postWPP  (27) adult male 01day    24 adult male 05day    21 adult male 30day    18 adult female 01day    17 adult female 05day    17 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    23 embryo 02-04hr    36 embryo 04-06hr    29 embryo 06-08hr    31 embryo 08-10hr    30 embryo 10-12hr    27 embryo 12-14hr    29 embryo 14-16hr    30 embryo 16-18hr    32 embryo 18-20hr    26 embryo 20-22hr    24 embryo 22-24hr    23 larva L1    16 larva L2    14 larva L3 12hr old    12 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9    33 white prepupae new    49 white prepupae 12hr    29 white prepupae 24hr    25 pupae 2d postWPP    24 pupae 3d postWPP    34 pupae 4d postWPP    27 adult male 01day    24 adult male 05day    21 adult male 30day    18 adult female 01day    17 adult female 05day    17 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    23 embryo 02-04hr    36 embryo 04-06hr    29 embryo 06-08hr    31 embryo 08-10hr    30 embryo 10-12hr    27 embryo 12-14hr    29 embryo 14-16hr    30 embryo 16-18hr    32 embryo 18-20hr    26 embryo 20-22hr    24 embryo 22-24hr    23 larva L1    16 larva L2    14 larva L3 12hr old    12 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9    33 white prepupae new    49 white prepupae 12hr    29 white prepupae 24hr    25 pupae 2d postWPP    24 pupae 3d postWPP    34 pupae 4d postWPP    27 adult male 01day    24 adult male 05day    21 adult male 30day    18 adult female 01day    17 adult female 05day    17 adult female 30day    17 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    23 embryo 02-04hr    36 embryo 04-06hr    29 embryo 06-08hr    31 embryo 08-10hr    30 embryo 10-12hr    27 embryo 12-14hr    29 embryo 14-16hr    30 embryo 16-18hr    32 embryo 18-20hr    26 embryo 20-22hr    24 embryo 22-24hr    23 larva L1    16 larva L2    14 larva L3 12hr old    12 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9    33 white prepupae new    49 white prepupae 12hr    29 white prepupae 24hr    25 pupae 2d postWPP    24 pupae 3d postWPP    34 pupae 4d postWPP    27 adult male 01day    24 adult male 05day    21 adult male 30day    18 adult female 01day    17 adult female 05day    17 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    23 embryo 02-04hr  (36) embryo 04-06hr  29 embryo 06-08hr  31 embryo 08-10hr  30 embryo 10-12hr  27 embryo 12-14hr  29 embryo 14-16hr  30 embryo 16-18hr  32 embryo 18-20hr  26 embryo 20-22hr    24 embryo 22-24hr    23 larva L1    16 larva L2    14 larva L3 12hr old    12 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9  (33) white prepupae new  (49) white prepupae 12hr  29 white prepupae 24hr    25 pupae 2d postWPP    24 pupae 3d postWPP  (34) pupae 4d postWPP  27 adult male 01day    24 adult male 05day    21 adult male 30day    18 adult female 01day    17 adult female 05day    17 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    23 embryo 02-04hr    36 embryo 04-06hr    29 embryo 06-08hr    31 embryo 08-10hr    30 embryo 10-12hr    27 embryo 12-14hr    29 embryo 14-16hr    30 embryo 16-18hr    32 embryo 18-20hr    26 embryo 20-22hr    24 embryo 22-24hr    23 larva L1    16 larva L2    14 larva L3 12hr old    12 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9    33 white prepupae new    49 white prepupae 12hr    29 white prepupae 24hr    25 pupae 2d postWPP    24 pupae 3d postWPP    34 pupae 4d postWPP    27 adult male 01day    24 adult male 05day    21 adult male 30day    18 adult female 01day    17 adult female 05day    17 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    23 embryo 02-04hr    36 embryo 04-06hr    29 embryo 06-08hr    31 embryo 08-10hr    30 embryo 10-12hr    27 embryo 12-14hr    29 embryo 14-16hr    30 embryo 16-18hr    32 embryo 18-20hr    26 embryo 20-22hr    24 embryo 22-24hr    23 larva L1    16 larva L2    14 larva L3 12hr old    12 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9    33 white prepupae new    49 white prepupae 12hr    29 white prepupae 24hr    25 pupae 2d postWPP    24 pupae 3d postWPP    34 pupae 4d postWPP    27 adult male 01day    24 adult male 05day    21 adult male 30day    18 adult female 01day    17 adult female 05day    17 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    16 Schneider line 2 Sg4    29 embryonic 1182-4H    31 embryonic GM2    31 embryonic Kc167    51 embryonic S1    20 embryonic S3    30 leg disc CME L1    24 wing disc CME-W2    49 wing disc ML-DmD8    30 wing disc ML-DmD9    37 wing disc ML-DmD16-c3    56 wing disc ML-DmD21    19 wing disc ML-DmD32    32 haltere disc ML-DmD17-c3    44 eye-antennal disc ML-DmD11    27 antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1    28 CNS ML-DmBG1-c1    46 CNS ML-DmBG2-c2    66 tumorous blood cells mbn2    32 ovary fGS/OSS    28 ovary OSC    43 ovary OSS    46 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    16 Schneider line 2 Sg4  (29) embryonic 1182-4H  (31) embryonic GM2  (31) embryonic Kc167  (51) embryonic S1    20 embryonic S3  (30) leg disc CME L1    24 wing disc CME-W2  (49) wing disc ML-DmD8  (30) wing disc ML-DmD9  (37) wing disc ML-DmD16-c3  (56) wing disc ML-DmD21    19 wing disc ML-DmD32  (32) haltere disc ML-DmD17-c3  (44) eye-antennal disc ML-DmD11  (27) antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1  (28) CNS ML-DmBG1-c1  (46) CNS ML-DmBG2-c2  (66) tumorous blood cells mbn2  (32) ovary fGS/OSS  (28) ovary OSC  (43) ovary OSS  (46) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    16 Schneider line 2 Sg4    29 embryonic 1182-4H    31 embryonic GM2    31 embryonic Kc167    51 embryonic S1    20 embryonic S3    30 leg disc CME L1    24 wing disc CME-W2    49 wing disc ML-DmD8    30 wing disc ML-DmD9    37 wing disc ML-DmD16-c3    56 wing disc ML-DmD21    19 wing disc ML-DmD32    32 haltere disc ML-DmD17-c3    44 eye-antennal disc ML-DmD11    27 antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1    28 CNS ML-DmBG1-c1    46 CNS ML-DmBG2-c2    66 tumorous blood cells mbn2    32 ovary fGS/OSS    28 ovary OSC    43 ovary OSS    46 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    16 Schneider line 2 Sg4    29 embryonic 1182-4H    31 embryonic GM2    31 embryonic Kc167    51 embryonic S1    20 embryonic S3    30 leg disc CME L1    24 wing disc CME-W2    49 wing disc ML-DmD8    30 wing disc ML-DmD9    37 wing disc ML-DmD16-c3    56 wing disc ML-DmD21    19 wing disc ML-DmD32    32 haltere disc ML-DmD17-c3    44 eye-antennal disc ML-DmD11    27 antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1    28 CNS ML-DmBG1-c1    46 CNS ML-DmBG2-c2    66 tumorous blood cells mbn2    32 ovary fGS/OSS    28 ovary OSC    43 ovary OSS    46 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    16 Schneider line 2 Sg4    29 embryonic 1182-4H    31 embryonic GM2    31 embryonic Kc167    51 embryonic S1    20 embryonic S3    30 leg disc CME L1    24 wing disc CME-W2    49 wing disc ML-DmD8    30 wing disc ML-DmD9    37 wing disc ML-DmD16-c3    56 wing disc ML-DmD21    19 wing disc ML-DmD32    32 haltere disc ML-DmD17-c3    44 eye-antennal disc ML-DmD11    27 antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1    28 CNS ML-DmBG1-c1    46 CNS ML-DmBG2-c2    66 tumorous blood cells mbn2    32 ovary fGS/OSS    28 ovary OSC    43 ovary OSS    46 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    16 Schneider line 2 Sg4  29 embryonic 1182-4H  31 embryonic GM2  31 embryonic Kc167  (51) embryonic S1    20 embryonic S3  30 leg disc CME L1    24 wing disc CME-W2  (49) wing disc ML-DmD8  30 wing disc ML-DmD9  (37) wing disc ML-DmD16-c3  (56) wing disc ML-DmD21    19 wing disc ML-DmD32  32 haltere disc ML-DmD17-c3  (44) eye-antennal disc ML-DmD11  27 antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1  28 CNS ML-DmBG1-c1  (46) CNS ML-DmBG2-c2  (66) tumorous blood cells mbn2  32 ovary fGS/OSS  28 ovary OSC  (43) ovary OSS  (46) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    16 Schneider line 2 Sg4    29 embryonic 1182-4H    31 embryonic GM2    31 embryonic Kc167    51 embryonic S1    20 embryonic S3    30 leg disc CME L1    24 wing disc CME-W2    49 wing disc ML-DmD8    30 wing disc ML-DmD9    37 wing disc ML-DmD16-c3    56 wing disc ML-DmD21    19 wing disc ML-DmD32    32 haltere disc ML-DmD17-c3    44 eye-antennal disc ML-DmD11    27 antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1    28 CNS ML-DmBG1-c1    46 CNS ML-DmBG2-c2    66 tumorous blood cells mbn2    32 ovary fGS/OSS    28 ovary OSC    43 ovary OSS    46 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    16 Schneider line 2 Sg4    29 embryonic 1182-4H    31 embryonic GM2    31 embryonic Kc167    51 embryonic S1    20 embryonic S3    30 leg disc CME L1    24 wing disc CME-W2    49 wing disc ML-DmD8    30 wing disc ML-DmD9    37 wing disc ML-DmD16-c3    56 wing disc ML-DmD21    19 wing disc ML-DmD32    32 haltere disc ML-DmD17-c3    44 eye-antennal disc ML-DmD11    27 antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1    28 CNS ML-DmBG1-c1    46 CNS ML-DmBG2-c2    66 tumorous blood cells mbn2    32 ovary fGS/OSS    28 ovary OSC    43 ovary OSS    46 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    26 cold shock, 4-day adult    21 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    17 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    28 Copper 0.5 mM 12 hrs, larvae L3    48 Copper 15 mM 48 hrs, 4-day adult    46 Zinc 5 mM 12 hrs, larvae L3    29 Zinc 4.5 mM 48 hrs, 4-day adult    38 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    27 Paraquat 5 mM 48 hrs, 4-day adult    22 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    13 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  26 cold shock, 4-day adult    21 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    17 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult  (28) Copper 0.5 mM 12 hrs, larvae L3  (48) Copper 15 mM 48 hrs, 4-day adult  (46) Zinc 5 mM 12 hrs, larvae L3  (29) Zinc 4.5 mM 48 hrs, 4-day adult  (38) Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult  (27) Paraquat 5 mM 48 hrs, 4-day adult    22 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    13 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    26 cold shock, 4-day adult    21 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    17 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    28 Copper 0.5 mM 12 hrs, larvae L3    48 Copper 15 mM 48 hrs, 4-day adult    46 Zinc 5 mM 12 hrs, larvae L3    29 Zinc 4.5 mM 48 hrs, 4-day adult    38 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    27 Paraquat 5 mM 48 hrs, 4-day adult    22 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    13 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    26 cold shock, 4-day adult    21 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    17 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    28 Copper 0.5 mM 12 hrs, larvae L3    48 Copper 15 mM 48 hrs, 4-day adult    46 Zinc 5 mM 12 hrs, larvae L3    29 Zinc 4.5 mM 48 hrs, 4-day adult    38 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    27 Paraquat 5 mM 48 hrs, 4-day adult    22 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    13 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    26 cold shock, 4-day adult    21 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    17 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    28 Copper 0.5 mM 12 hrs, larvae L3    48 Copper 15 mM 48 hrs, 4-day adult    46 Zinc 5 mM 12 hrs, larvae L3    29 Zinc 4.5 mM 48 hrs, 4-day adult    38 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    27 Paraquat 5 mM 48 hrs, 4-day adult    22 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    13 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  26 cold shock, 4-day adult    21 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    17 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult  28 Copper 0.5 mM 12 hrs, larvae L3  (48) Copper 15 mM 48 hrs, 4-day adult  (46) Zinc 5 mM 12 hrs, larvae L3  29 Zinc 4.5 mM 48 hrs, 4-day adult  (38) Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult  27 Paraquat 5 mM 48 hrs, 4-day adult    22 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    13 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    26 cold shock, 4-day adult    21 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    17 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    28 Copper 0.5 mM 12 hrs, larvae L3    48 Copper 15 mM 48 hrs, 4-day adult    46 Zinc 5 mM 12 hrs, larvae L3    29 Zinc 4.5 mM 48 hrs, 4-day adult    38 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    27 Paraquat 5 mM 48 hrs, 4-day adult    22 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    13 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    26 cold shock, 4-day adult    21 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    17 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    28 Copper 0.5 mM 12 hrs, larvae L3    48 Copper 15 mM 48 hrs, 4-day adult    46 Zinc 5 mM 12 hrs, larvae L3    29 Zinc 4.5 mM 48 hrs, 4-day adult    38 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    27 Paraquat 5 mM 48 hrs, 4-day adult    22 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    13 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_27 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	BDGP expression data • MIP03616 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003371 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2621-RA;HDC17143;CG2621-RB
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal sggED6584 lethal | embryonic stage sggM11 lethal | embryonic stage | germline clone sgg10 sggM11 sggMA27 lethal | embryonic stage | germline clone | maternal effect | recessive sggM11 lethal | embryonic stage | maternal effect sgg1 lethal | embryonic stage | non-rescuable maternal effect sgg9 sgg10 lethal | embryonic stage | rescuable maternal effect sggM11 lethal | germline clone | maternal effect sgg10 lethal | heat sensitive, with Scer\GAL4how-24B sggScer\UAS.cSa lethal | larval stage sggG0055 lethal | larval stage | recessive sgg1 sgg2 sgg5 sgg9 sgg10 sgg32 lethal | maternal effect sgg1 sgg3m1 sgg10 sggM11 sggMA27 lethal | pharate adult stage sggG0263 lethal | pharate adult stage, with Scer\GAL4ey.PH sggScer\UAS.cBa lethal | pharate adult stage, with Scer\GAL4GMR.PF sggScer\UAS.cBa lethal | prepupal stage sggG0055 lethal | pupal stage sggG0055 sggG0183 sggG0335 lethal | pupal stage, with Scer\GAL4ey.PH sggScer\UAS.cBa lethal | pupal stage, with Scer\GAL4GMR.PF sggScer\UAS.cBa lethal | pupal stage, with Scer\GAL4sca-537.4 sggS9E.Scer\UAS lethal | recessive sgg1 sgg2 sgg3 sgg3Ba31 sgg5 sgg6 sgg7 sgg8 sgg9 sgg10 sgg11 sgg12 sgg13 sgg14 sgg15 sgg16 sgg17 sgg18 sgg19 sgg20 sgg21 sgg22 sgg23 sgg32 sggG0055 sggG0183 sggG0263 sggG0335 sggM7 sggM13 sggM28 sggM33 sggM50 sggM61 sggPL36 lethal | third instar larval stage sgg10 viable sggCA06683 sggPT004 sggZCL1626 viable, with Scer\GAL4GMR.PFa sggScer\UAS.cBa viable, with Scer\GAL4pnr-MD237 sggGD1331 Sterility Allele fertile sggZCL1626 Other Phenotypes Allele behavior defective sggE3 sggE6 sggEP1379 sggEP1576 sggtwkr behavior defective, with Scer\GAL4elav-C155 sggA81T.Scer\UAS sggS9A.Scer\UAS sggScer\UAS.cBa behavior defective, with Scer\GAL4tim.PE sggEP1576 behavior defective, with Scer\GAL4tim.PE, Scer\GAL80Pdf.PS sggEP1576 cell polarity defective sggM11 chemical sensitive | recessive sggJC05 circadian rhythm defective sggE6 sggtwkr circadian rhythm defective, with Scer\GAL4tim.PE sggEP1576 sggS9A.Scer\UAS sggScer\UAS.cBa circadian rhythm defective, with Scer\GAL4tim.PE, Scer\GAL80Pdf.PS sggEP1576 developmental rate defective sgg2 sgg3 sgg5 locomotor rhythm defective, with Scer\GAL4tim.PE sggEP1576 locomotor rhythm defective, with Scer\GAL4tim.PE, Scer\GAL80Pdf.PS sggEP1576 locomotor rhythm defective, with Scer\GAL4tim.Scer\UAS sggEP1576 sggScer\UAS.cBa locomotor rhythm defective, with sgg32 sgghs.P locomotor rhythm defective, with sgghs.P sgg32 sggM11 locomotor rhythm defective, with sggM11 sgghs.P locomotor rhythm defective, with sggM11/sgg32 sgghs.P locomotor rhythm defective (with sgg32), with sgghs.P sggM11 locomotor rhythm defective (with sggM11), with sgghs.P sgg32 meiotic cell cycle defective | germline clone sgg1 sgg32 mitotic cell cycle defective | somatic clone sggM1-1 mitotic cell cycle defective | third instar larval stage sgg1 neuroanatomy defective, with Scer\GAL4796 sggScer\UAS.cBa neuroanatomy defective, with Scer\GAL4da.G32 sggScer\UAS.cBa neuroanatomy defective, with Scer\GAL4elav-C155 sggA81T.Scer\UAS sggEY02862 neuroanatomy defective, with Scer\GAL4exba-krasavietz sggScer\UAS.cBa neuroanatomy defective, with Scer\GAL4GH298 sggScer\UAS.cBa neuroanatomy defective, with Scer\GAL4NP1227 sggScer\UAS.cBa neuroanatomy defective, with Scer\GAL4Sxl-NP2426 sggScer\UAS.cBa neuroanatomy defective, with Scer\GAL4Sxl-NP2426, Scer\GAL4exba-krasavietz sggScer\UAS.cBa neuroanatomy defective | larval stage sgg10 neuroanatomy defective | larval stage, with Scer\GAL4elav.PU sggA81T.Scer\UAS sggS9A.Scer\UAS neuroanatomy defective | larval stage, with Scer\GAL4elav-C155 sggA81T.Scer\UAS neurophysiology defective, with Scer\GAL4elav-C155 sggA81T.Scer\UAS sggEY02862 neurophysiology defective, with Scer\GAL4Rapgap1-OK6 sggA81T.Scer\UAS sggEY02862 neurophysiology defective | larval stage, with Scer\GAL4futsch-C380 sggA81T.Scer\UAS sggScer\UAS.cBa planar polarity defective sggM11 planar polarity defective, with Scer\GAL4GMR.PS sggScer\UAS.cSa planar polarity defective | cell non-autonomous | recessive | somatic clone sggM11 planar polarity defective | somatic clone sgg32 short lived, with Scer\GAL4tim.Scer\UAS sggScer\UAS.cBa smell perception defective, with Scer\GAL4exba-krasavietz sggScer\UAS.cBa smell perception defective, with Scer\GAL4GH298 sggScer\UAS.cBa smell perception defective, with Scer\GAL4GH298, Scer\GAL80ts.αTub84B sggScer\UAS.cBa smell perception defective, with Scer\GAL4Sxl-NP2426 sggScer\UAS.cBa visible sgg32 visible, with Scer\GAL4455.2 sggS9A.Scer\UAS sggS9E.Scer\UAS sggScer\UAS.cBa sggY214F.Scer\UAS visible, with Scer\GAL4bi-md653 sggScer\UAS.cBa visible, with Scer\GAL4Bx-MS1096 sggScer\UAS.cSa visible, with Scer\GAL4C-765 sggS9A.Scer\UAS sggScer\UAS.cBa visible, with Scer\GAL4dpp.blk1 sggScer\UAS.cSa visible, with Scer\GAL4GMR.PFa sggScer\UAS.cBa visible, with Scer\GAL4sca-537.4 sggS9A.Scer\UAS sggScer\UAS.cBa visible, with Scer\GAL4sca-P309 sggD235G.D300G.Scer\UAS.T:Hsap\MYC sggdsRNA.10.Scer\UAS sggdsRNA.46.Scer\UAS visible, with Scer\GAL4sd-SG29.1 sggScer\UAS.cSa visible, with Scer\GAL4vg.PM sggS9A.Scer\UAS sggS9E.Scer\UAS sggScer\UAS.cBa visible, with Scer\GAL4vg.PU sggScer\UAS.cSa visible | embryonic stage | germline clone | maternal effect | recessive sggM11 visible | pharate adult stage, with Scer\GAL4ey.PH sggScer\UAS.cBa visible | pharate adult stage, with Scer\GAL4GMR.PF sggScer\UAS.cBa visible | recessive | somatic clone sgg32 visible | somatic clone sgg3B5 sgg8C18 sgg32 sggM1-1 sggM11 sggunspecified wild-type sggA.hs sgghs.P sggmR10 Phenotype manifest in Allele 1st axillary sclerite | somatic clone sgg32 2nd axillary sclerite | somatic clone sgg32 3rd axillary sclerite, with Scer\GAL4Bx-MS1096 sggScer\UAS.cSa 3rd axillary sclerite | ectopic | somatic clone sgg32 abdominal 1 ventral denticle belt sggM11 abdominal 2 ventral denticle belt sggM11 abdominal 3 ventral denticle belt sggM11 abdominal 4 ventral denticle belt sggM11 abdominal 5 ventral denticle belt sggM11 abdominal 6 ventral denticle belt sggM11 abdominal 7 ventral denticle belt sggM11 adult cuticle & abdomen | somatic clone sgg32 adult thorax & chaeta, with Scer\GAL4sca-537.4 sggS9A.Scer\UAS sggS9E.Scer\UAS sggScer\UAS.cBa adult thorax & macrochaeta | somatic clone sgg32 adult thorax & microchaeta, with Scer\GAL4sca-537.4 sggScer\UAS.cBa adult thorax & microchaeta | somatic clone sgg32 adult thorax | dorsal | ectopic, with Scer\GAL4sd-SG29.1 sggScer\UAS.cSa antennal lobe, with Scer\GAL4exba-krasavietz sggScer\UAS.cBa antennal lobe, with Scer\GAL4GH298 sggScer\UAS.cBa antennal lobe, with Scer\GAL4NP1227 sggScer\UAS.cBa antennal lobe, with Scer\GAL4Sxl-NP2426 sggScer\UAS.cBa antennal lobe, with Scer\GAL4Sxl-NP2426, Scer\GAL4exba-krasavietz sggScer\UAS.cBa antennal lobe, with Scer\GAL4Tab2-201Y sggScer\UAS.cBa antennal lobe glomerulus DM2, with Scer\GAL4GH298 sggScer\UAS.cBa axillary pouch, with Scer\GAL4dpp.blk1 sggScer\UAS.cSa axillary pouch | somatic clone sgg32 bouton sgg10 bouton (with Df(1)64j4) sgg10 bouton | larval stage, with Scer\GAL4elav.PU sggS9A.Scer\UAS bouton | larval stage | supernumerary sgg10 bouton | larval stage | supernumerary, with Scer\GAL4elav.PU sggA81T.Scer\UAS bouton | supernumerary, with Scer\GAL4BG380 sggA81T.Scer\UAS bouton | supernumerary, with Scer\GAL4elav-C155 sggA81T.Scer\UAS bouton | supernumerary, with Scer\GAL4Rapgap1-OK6 sggA81T.Scer\UAS crystal cell, with Scer\GAL4He.PZ sggS9A.Scer\UAS cuprophilic cell, with Scer\GAL4how-24B sggScer\UAS.cSa cuticle | ectopic | somatic clone sgg32 denticle | germline clone | rescuable maternal effect sggM11 denticle belt sggM11 denticle belt | germline clone sggM11 denticle belt | germline clone | maternal effect sgg10 sggM11 sggMA27 denticle belt | maternal effect sggM11 dorsal denticle, with Scer\GAL4da.G32 sggScer\UAS.cSa dorsal hair sggM1-1 dorsocentral bristle, with Scer\GAL4C-765 sggS9A.Scer\UAS egg | germline clone sgg9 egg | germline clone | non-rescuable maternal effect sgg10 embryonic/first instar larval cuticle sggM11 embryonic/first instar larval cuticle, with Scer\GAL469B sggScer\UAS.cSa embryonic/first instar larval cuticle, with Scer\GAL4da.G32 sggScer\UAS.cSa embryonic/first instar larval cuticle | dorsal sggM1-1 embryonic/first instar larval cuticle | germline clone | maternal effect sgg10 sggM11 sggMA27 embryonic/first instar larval cuticle | germline clone | rescuable maternal effect sggM11 embryonic/first instar larval cuticle | maternal effect sggM11 embryonic/larval brain | embryonic stage | germline clone | maternal effect sgg10 sggM11 sggMA27 embryonic/larval dorsal vessel sggA.hs embryonic/larval dorsal vessel | precursor sggM11 embryonic/larval neuromuscular junction sgg10 embryonic/larval neuromuscular junction, with Scer\GAL4futsch-C380 sggA81T.Scer\UAS sggScer\UAS.cBa embryonic/larval neuromuscular junction (with Df(1)64j4) sgg10 embryonic/larval somatic muscle | germline clone sggM11 embryonic/larval spiracle | germline clone | maternal effect sgg10 sggM11 sggMA27 embryonic epidermis | dorsal sggM1-1 embryonic epidermis | dorsal, with Scer\GAL4da.G32 sggScer\UAS.cSa embryonic epidermis | germline clone sgg10 embryonic head | germline clone | maternal effect sgg10 sggM11 sggMA27 embryonic Malpighian tubule | germline clone sggM11 external sensory organ precursor cell | somatic clone sgg1 eye, with Scer\GAL4GMR.PFa sggScer\UAS.cBa eye, with Scer\GAL4GMR.PS sggScer\UAS.cSa eye | pharate adult stage, with Scer\GAL4ey.PH sggScer\UAS.cBa eye | pharate adult stage, with Scer\GAL4GMR.PF sggScer\UAS.cBa eye | somatic clone sgg3B5 sgg8C18 sggM1-1 sggM11 eye disc | somatic clone sggM1-1 eye disc | somatic clone | third instar larval stage sgg8C18 female reproductive system sgg9 female reproductive system | non-rescuable maternal effect sgg10 filzkorper | germline clone | maternal effect sgg10 sggM11 sggMA27 follicle cell | somatic clone sggM1-1 follicle stem cell | somatic clone sggM1-1 germline cyst | somatic clone sggM1-1 head | pharate adult stage, with Scer\GAL4ey.PH sggScer\UAS.cBa head | pharate adult stage, with Scer\GAL4GMR.PF sggScer\UAS.cBa imaginal disc | somatic clone sggunspecified interommatidial bristle, with Scer\GAL4elav-C155 sggScer\UAS.cSa intrinsic neuron, with Scer\GAL4exba-krasavietz sggScer\UAS.cBa intrinsic neuron, with Scer\GAL4GH298 sggScer\UAS.cBa intrinsic neuron, with Scer\GAL4NP1227 sggScer\UAS.cBa intrinsic neuron, with Scer\GAL4Sxl-NP2426 sggScer\UAS.cBa intrinsic neuron, with Scer\GAL4Sxl-NP2426, Scer\GAL4exba-krasavietz sggScer\UAS.cBa intrinsic neuron, with Scer\GAL4Tab2-201Y sggScer\UAS.cBa lamellocyte, with Scer\GAL4He.PZ sggS9A.Scer\UAS leg sgg32 sggM11 leg | somatic clone sggM1-1 macrochaeta sgg32 macrochaeta, with Scer\GAL4sca-P309 sggΔN300.Scer\UAS.T:Hsap\MYC sgg10.Scer\UAS.T:Hsap\MYC macrochaeta & mesothoracic tergum | somatic clone | cell autonomous sgg32 macrochaeta & prescutum | somatic clone | cell autonomous sgg32 macrochaeta & scutum | somatic clone | cell autonomous sgg32 macrochaeta & wing sggM11 macrochaeta & wing | ectopic | somatic clone sgg32 macrochaeta | cell autonomous | ectopic | somatic clone sgg32 macrochaeta | ectopic sggM11 macrochaeta | ectopic | maternal effect | somatic clone sgg1 sgg3m1 macrochaeta | ectopic | somatic clone sgg32 macrochaeta | somatic clone sgg1 sggM1-1 macrochaeta | somatic clone | supernumerary sgg32 macrochaeta | supernumerary, with Scer\GAL4sca-P309 sggdsRNA.10.Scer\UAS sggdsRNA.46.Scer\UAS sggD235G.D300G.Scer\UAS.T:Hsap\MYC mechanosensory ventral triple row bristle | ectopic | somatic clone sggM11 melanotic mass, with Scer\GAL4He.PZ sggS9A.Scer\UAS mesothoracic tarsal bristle longitudinal row 2 sggM11 mesothoracic tarsal bristle longitudinal row 3 sggM11 mesothoracic tarsal bristle longitudinal row 4 sggM11 mesothoracic tarsal bristle longitudinal row 5 sggM11 mesothoracic tarsal bristle longitudinal row 6 sggM11 mesothoracic tarsal bristle longitudinal row 7 sggM11 mesothoracic tergum, with Scer\GAL4455.2 sggS9A.Scer\UAS sggS9E.Scer\UAS sggScer\UAS.cBa mesothoracic tergum | ectopic, with Scer\GAL4vg.PM sggS9A.Scer\UAS sggS9E.Scer\UAS sggScer\UAS.cSa microchaeta | ectopic | somatic clone sgg32 microchaeta | somatic clone | supernumerary sgg32 midgut constriction 1 | germline clone sggM11 midgut constriction 2, with Scer\GAL4how-24B sggScer\UAS.cSa morphogenetic furrow, with Scer\GAL4dpp.blk1 sggS9A.Scer\UAS mushroom body, with Scer\GAL4Mef2.247 sggScer\UAS.cBa mushroom body, with Scer\GAL4Tab2-201Y sggScer\UAS.cBa NMJ bouton | larval stage | supernumerary, with Scer\GAL4elav-C155 sggA81T.Scer\UAS nucleus | embryonic stage 4 | germline clone sggM1-1 ommatidium sgghs.sev ommatidium | cell non-autonomous | somatic clone sggM11 ommatidium | somatic clone sgg32 posterior dorsocentral bristle, with Scer\GAL4C-765 sggS9A.Scer\UAS sggScer\UAS.cBa presumptive embryonic/larval central nervous system | germline clone | maternal effect sgg10 sggM11 sggMA27 presumptive embryonic/larval peripheral nervous system | germline clone | maternal effect sgg10 sggM11 sggMA27 scutellar bristle, with Scer\GAL4455.2 sggScer\UAS.cBa sggY214F.Scer\UAS scutellum, with Scer\GAL4455.2 sggS9A.Scer\UAS sggS9E.Scer\UAS sggScer\UAS.cBa sensillum campaniformium sggM11 sensory mother cell, with Scer\GAL4sca-P309 sggΔN300.Scer\UAS.T:Hsap\MYC sgg10.Scer\UAS.T:Hsap\MYC sensory mother cell | supernumerary, with Scer\GAL4sca-P309 sggD235G.D300G.Scer\UAS.T:Hsap\MYC stomodeal invagination sggM11 synapse, with Scer\GAL4796 sggScer\UAS.cBa synapse, with Scer\GAL4da.G32 sggScer\UAS.cBa synapse, with Scer\GAL4elav-C155 sggA81T.Scer\UAS sggEY02862 synapse, with Scer\GAL4exba-krasavietz sggScer\UAS.cBa synapse, with Scer\GAL4GH298 sggScer\UAS.cBa synapse, with Scer\GAL4NP1227 sggScer\UAS.cBa synapse, with Scer\GAL4Sxl-NP2426 sggScer\UAS.cBa synapse, with Scer\GAL4Sxl-NP2426, Scer\GAL4exba-krasavietz sggScer\UAS.cBa synapse, with Scer\GAL4Tab2-201Y sggScer\UAS.cBa syncytial blastoderm embryo | germline clone sggM1-1 tarsal segment | somatic clone | supernumerary sggM1-1 tibia | somatic clone sggM1-1 unnamed wing hinge sclerite | somatic clone sgg32 ventral thoracic disc & macrochaeta | somatic clone sggM1-1 ventral thoracic disc | somatic clone sggM1-1 wing sggM11 wing, with Scer\GAL430A sggScer\UAS.cBa wing, with Scer\GAL4bi-md653 sggScer\UAS.cBa wing, with Scer\GAL4Bx-MS1096 sggScer\UAS.cSa wing, with Scer\GAL4sca-537.4 sggS9A.Scer\UAS sggS9E.Scer\UAS wing, with Scer\GAL4sd-SG29.1 sggScer\UAS.cSa wing, with Scer\GAL4vg.PM sggS9A.Scer\UAS sggS9E.Scer\UAS sggScer\UAS.cSa wing | anterior | somatic clone sgg32 wing | maternal effect sgg10 sggM11 sggMA27 wing | maternal effect | somatic clone sgg1 sgg3m1 wing | posterior compartment sggM11 wing | somatic clone sggM11 sggunspecified wing blade | somatic clone sggM11 wing disc, with Scer\GAL4455.2 sggScer\UAS.cBa wing disc, with Scer\GAL4vg.PM sggScer\UAS.cSa wing hair | maternal effect | somatic clone sgg1 sgg3m1 wing margin, with Scer\GAL4Bx-MS1096 sggScer\UAS.cSa wing margin, with Scer\GAL4vg.PM sggS9A.Scer\UAS sggS9E.Scer\UAS sggScer\UAS.cBa sggScer\UAS.cSa wing margin, with Scer\GAL4vg.PU sggScer\UAS.cSa wing margin bristle, with Scer\GAL4sca-537.4 sggS9A.Scer\UAS sggS9E.Scer\UAS sggScer\UAS.cBa wing margin bristle, with Scer\GAL4vg.PM sggScer\UAS.cBa wing margin bristle, with Scer\GAL4vg.PU sggScer\UAS.cSa wing margin bristle | ectopic | somatic clone sggM11 sggunspecified wing sensillum | ectopic | somatic clone sggM11 wing vein | ectopic | somatic clone sggM11
Classical Alleles ( 124 )
For All Classical Alleles Show
Allele of sgg Class Mutagen Stocks Known lesion sgg1 amorphic allele - genetic evidence, hypomorphic allele - genetic evidence X ray 2 Yes sggG0055 P-element activity 2 -- sggG0183 P-element activity 2 -- sggG0335 P-element activity 2 -- sggM11 loss of function allele, amorphic allele - genetic evidence spontaneous 1 -- sgg4 X ray 1 -- sgg5-SZ-3093 1 -- sggCB-5590-3 1 -- sggd00428 P-element activity 1 -- sggd01056 1 -- sggd03768 P-element activity 1 -- sggd07708 P-element activity 1 -- sggd10160 P-element activity 1 -- sggEP1576 P-element activity 1 Yes sggEY02862 P-element activity 1 -- sggf00462 piggyBac transposase 1 -- sggf04468 1 -- sggf07311 piggyBac transposase 1 -- sggG0263 P-element activity 1 -- sggKG01982 1 -- sggKG02219 1 -- sggKG02594 1 -- sggKG08704 P-element activity 1 -- sggM1-1 1 -- sggMB03827 1 -- sggNP0082 1 -- sggNP0085 1 -- sggNP0122 1 -- sggNP0626 1 -- sggNP0715 1 -- sggNP2253 1 -- sggNP4101 1 -- sggNP7142 1 -- sggNP7167 1 -- sggNP7270 1 -- sgg32 loss of function allele, amorphic allele - genetic evidence ethyl methanesulfonate 0 -- sggSE17 amorphic allele - genetic evidence 0 -- sggSE2 amorphic allele - genetic evidence 0 -- sggSE3 amorphic allele - genetic evidence 0 -- sggSE6 amorphic allele - genetic evidence 0 -- sggSE7 amorphic allele - genetic evidence 0 -- sgg10 hypomorphic allele - genetic evidence ethylenimine 0 -- sgg11 ethyl methanesulfonate 0 -- sgg12 ethyl methanesulfonate 0 -- sgg13 ethyl methanesulfonate 0 -- sgg14 ethyl methanesulfonate 0 -- sgg15 ethyl methanesulfonate 0 -- sgg16 methyl methanesulfonate 0 -- sgg17 methyl methanesulfonate 0 -- sgg18 methyl methanesulfonate 0 -- sgg19 methyl methanesulfonate 0 -- sgg20 methyl methanesulfonate 0 -- sgg21 methyl methanesulfonate 0 -- sgg22 methyl methanesulfonate 0 -- sgg23 methyl methanesulfonate 0 -- sgg24 X ray 0 -- sgg25 X ray 0 -- sgg26 X ray 0 -- sgg27 X ray 0 -- sgg28 X ray 0 -- sgg29 ethyl methanesulfonate 0 -- sgg2 hypomorphic allele - genetic evidence X ray 0 -- sgg30 ethyl methanesulfonate 0 -- sgg31 spontaneous 0 -- sgg3 X ray 0 -- sgg3B5 ethyl methanesulfonate 0 -- sgg3Ba31 0 -- sgg3m1 ethyl methanesulfonate 0 -- sgg5 X ray ethylenimine 0 -- sgg6 ethylenimine 0 -- sgg7 ethyl methanesulfonate 0 -- sgg8 X ray 0 -- sgg8C18 ethyl methanesulfonate 0 -- sgg9 X ray 0 -- sggCA06683 P-element activity 0 Yes sggCPTI000023 piggyBac transposase 0 Yes sggCPTI000854 piggyBac transposase 0 Yes sggCPTI001231 0 -- sggCPTI002603 piggyBac transposase 0 Yes sggCPTI100027 piggyBac transposase 0 Yes sggd03640 P-element activity 0 -- sggd04069 0 -- sggd04107 P-element activity 0 -- sggd04342 P-element activity 0 -- sggd07627 0 -- sggE3 P-element activity 0 Yes sgge6 0 -- sggE6 P-element activity 0 Yes sggED6584 0 -- sggEP1379 P-element activity 0 -- sggG00015 P-element activity 0 -- sggG138 P-element activity 0 Yes sggG33 P-element activity 0 Yes sggGG01041 0 -- sggGG01088 0 -- sggGG01196 0 -- sggGG01441 0 -- sggGG01840 0 -- sggJC05 P-element activity 0 Yes sggL0 0 -- sggL1 0 -- sggM13 methyl methanesulfonate 0 -- sggm1H 0 -- sggM28 methyl methanesulfonate 0 -- sggM33 methyl methanesulfonate 0 -- sggM50 methyl methanesulfonate 0 -- sggM61 methyl methanesulfonate 0 -- sggM7 methyl methanesulfonate 0 -- sggMA27 methyl methanesulfonate 0 -- sggNKu1 urethane 0 -- sggNKu2 urethane 0 -- sggNKx1 X ray 0 -- sggNKx2 X ray 0 -- sggNKx3 X ray 0 -- sggNKx4 X ray 0 -- sggNKx5 X ray 0 -- sggPL36 Delta2-3 0 -- sggPS 0 -- sggPT004 0 -- sggS361 0 -- sggtwkr 0 -- sggunspecified 0 -- sggYD0060 piggyBac transposase 0 -- sggZCL1626 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 45 )
For All Alleles Carried on Transgenic Constructs Show
Allele of sgg Class Mutagen Stocks Known lesion sggS9A.Scer\UAS in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 4 Yes sggScer\UAS.cBa in vitro construct - regulatory fusion 4 Yes sggA81T.Scer\UAS in vitro construct - regulatory fusion in vitro construct - amino acid replacement 3 Yes sggGL00277 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes sggHMS01751 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes sggJF01255 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes sggJF01256 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes sggKK108994 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes sggKK83-84MI.Scer\UAS in vitro construct - regulatory fusion in vitro construct - amino acid replacement 1 Yes sggKK83-84RK.Scer\UAS in vitro construct - regulatory fusion in vitro construct - amino acid replacement 1 Yes sggS9E.Scer\UAS in vitro construct - regulatory fusion in vitro construct - amino acid replacement 1 Yes sggY214F.Scer\UAS in vitro construct - regulatory fusion in vitro construct - amino acid replacement 1 Yes sgg10.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes sgg46.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes sgga.cYa in vitro construct - RNAi 0 Yes sggA.hs in vitro construct - regulatory fusion 0 Yes sgga.NB10 in vitro construct 0 Yes sgga.NB6 in vitro construct 0 Yes sggAct5C.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes sggAct5C.T:Zzzz\His6 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes sggcYa in vitro construct - RNAi 0 Yes sggD235G.D300G.Scer\UAS.T:Hsap\MYC in vitro construct - amino acid replacement 0 Yes sggD235G.Scer\UAS.T:Hsap\MYC in vitro construct - amino acid replacement 0 Yes sggD300G.Scer\UAS.T:Hsap\MYC in vitro construct - coding region fusion 0 Yes sggdsRNA.10.Scer\UAS in vitro construct - coding region fusion in vitro construct - RNAi 0 Yes sggdsRNA.46.Scer\UAS in vitro construct - coding region fusion in vitro construct - RNAi 0 Yes sggdsRNA.cLa in vitro construct - RNAi 0 Yes sggdsRNA.cSa in vitro construct - RNAi 0 Yes sggdsRNA.cYa in vitro construct - RNAi 0 Yes sggGD1331 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes sgghs.P in vitro construct - regulatory fusion 0 Yes sgghs.sev in vitro construct - regulatory fusion 0 Yes sggK83R.MtnA.T:Ivir\HA1 in vitro construct - coding region fusion in vitro construct - amino acid replacement in vitro construct - site directed mutagenesis in vitro construct - regulatory fusion 0 Yes sggK83R.Scer\UAS.T:Hsap\MYC in vitro construct - amino acid replacement 0 Yes sggKR.Scer\UAS.T:Avic\GFP-CFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - site directed mutagenesis 0 Yes sggmR10 in vitro construct - minigene 0 Yes sggmR39 in vitro construct - minigene 0 -- sggmR46 in vitro construct - minigene 0 -- sggMtnA.cRa.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes sggMtnA.T:Ivir\HA1 in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes sggNIG.2621R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes sggScer\UAS.cSa in vitro construct - regulatory fusion 0 Yes sggScer\UAS.P\T.cTa in vitro construct - regulatory fusion 0 Yes sggΔN235.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes sggΔN300.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)7 (Nomura and Kurokawa, 1997) Df(1)64c4 (Judd et al., 1972, Thierry-Mieg, 1982) Df(1)64f1 (Judd et al., 1972, Thierry-Mieg, 1982, Perrimon and Smouse, 1989, Lin and Wolfner, 1989, Bourouis et al., 1990) Df(1)64j4 (Judd et al., 1972, Thierry-Mieg, 1982, Perrimon and Smouse, 1989, Lin and Wolfner, 1989, Bourouis et al., 1990) Df(1)ED411 (Lear et al., 2005) Df(1)HM3 (Kramers et al., 1983) Df(1)HM406 (Kramers et al., 1983) Df(1)K95 (Judd et al., 1972, Thierry-Mieg, 1982, Perrimon and Smouse, 1989, Robbins, 1990) Df(1)TEM1 (Lim and Snyder, 1974, Kramers et al., 1983, Kramers et al., 1991) Df(1)TEM7 (Lim and Snyder, 1974, Liu and Lim, 1975, Thierry-Mieg, 1982, Paradi et al., 1983, Kramers et al., 1983, Kramers et al., 1991, Lear et al., 2005) Df(1)TEM75 (Lim and Snyder, 1974) Df(1)TEM501 (Lim and Snyder, 1974, Kramers et al., 1983, Kramers et al., 1991) Df(1)w258-11 (Judd et al., 1972, Thierry-Mieg, 1982) Df(1)w258-42 (Judd et al., 1972, Thierry-Mieg, 1982) Df(1)w258-45 (Robbins, 1990) Df(1)w258-48 (Kramers et al., 1983, Kramers et al., 1991) Df(1)w-N71a (Judd et al., 1972) Df(1)w-rJ1 (Judd et al., 1972, Lim and Snyder, 1974, Liu and Lim, 1975, Thierry-Mieg, 1982, Paradi et al., 1983, Kramers et al., 1983, Kramers et al., 1991, Nomura and Kurokawa, 1997) Df(1)w-rJ2 (Judd et al., 1972) Df(1)X12 (Judd et al., 1972, Thierry-Mieg, 1982) Df(1)z-deb62 (Goldberg et al., 1989) Df(1)z-deb65 (Goldberg et al., 1989) Df(1)z-deb72 (Goldberg et al., 1989) Df(1)z-deb81 (Goldberg et al., 1989) Df(1)z-deb85 (Goldberg et al., 1989) Df(1)z-deb511 (Goldberg et al., 1989)
Duplicated in	Dp(1;2;Y)w+ (Judd et al., 1972, Kramers et al., 1983, Kramers et al., 1991) Dp(1;2)w+70h (Judd et al., 1972, Jiang and Struhl, 1996) Dp(1;3)DC048 (Popodi, 2010.10.8, Venken et al., 2010) Dp(1;3)w+67k (Judd et al., 1972) Dp(1;Y)y267g19.1 (Lefevre, 1981)
Not disrupted in	Df(1)62d18 (Judd et al., 1972, Bourouis et al., 1990) Df(1)62g18 (Judd et al., 1972, Thierry-Mieg, 1982) Df(1)64f1 (Siegfried et al., 1990) Df(1)64j4 (Siegfried et al., 1990) Df(1)65j26 (Judd et al., 1972, Thierry-Mieg, 1982) Df(1)202 (Nomura and Kurokawa, 1997) Df(1)304 (Nomura and Kurokawa, 1997) Df(1)L126 (Nomura and Kurokawa, 1997) Df(1)N-8 (Lin and Wolfner, 1989, Kramers et al., 1991) Df(1)N-54l9 (Kramers et al., 1991) Df(1)N-264-105 (Kramers et al., 1991) Df(1)Pgd-kz (Kramers et al., 1991) Df(1)Sp2F-3A (Schalet, 1986, Lear et al., 2005) Df(1)TEM6 (Lim and Snyder, 1974) Df(1)TEM202 (Liu and Lim, 1975, Paradi et al., 1983, Kramers et al., 1983, Kramers et al., 1991) Df(1)TEM304 (Lim and Snyder, 1974, Liu and Lim, 1975, Paradi et al., 1983, Kramers et al., 1983, Kramers et al., 1991) Df(1)w55j (Lin and Wolfner, 1989) Df(1)w67k30 (Kramers et al., 1991) Df(1)w258-45 (Judd et al., 1972, Thierry-Mieg, 1982, Lin and Wolfner, 1989) Df(1)z-deb3 (Goldberg et al., 1989) Df(1)z-deb42 (Goldberg et al., 1989) Df(1)z-deb54 (Goldberg et al., 1989) Df(1)z-deb59 (Goldberg et al., 1989) Df(1)z-deb87 (Goldberg et al., 1989) Df(1)z-deb92 (Goldberg et al., 1989) Df(1)z-deb311 (Goldberg et al., 1989) Df(1)z-deb910 (Goldberg et al., 1989)
Not duplicated in	Dp(1;2)51b (Kramers et al., 1991) Dp(1;3)N264-58 (Judd et al., 1972) Dp(1;3)wm49a (Judd et al., 1972) Dp(1;3)wvco (Schalet, 1986) Dp(1;4)wm65g (Judd et al., 1972)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1331} NA P{KK108994} NA P{NIG.2621R} NA P{TRiP.GL00277} NA P{TRiP.HMS01751} NA P{TRiP.JF01255} NA P{TRiP.JF01256} NA P{UASp-sgg.T} NA P{UAS-sgg.10.MYC} NA P{UAS-sgg.46.MYC} NA P{UAS-sgg.A81T} NA P{UAS-sgg.B} NA P{UAS-sgg.dsRNA.10} NA P{UAS-sgg.dsRNA.46} NA P{UAS-sgg.KK83-84MI} NA P{UAS-sgg.KK83-84RK} NA P{UAS-sgg.KR.CFP} NA P{UAS-sgg.MYC.D235G/D300G} NA P{UAS-sgg.MYC.K83R} NA P{UAS-sgg.MYC.ΔN235} NA P{UAS-sgg.MYC.ΔN300} NA P{UAS-sgg.S9A} NA P{UAS-sgg.S9E} NA P{UAS-sgg.S} NA P{UAS-sgg.Y214F} NA heat-shock construct P{hs-sgg.A} NA P{hs-sgg.P} NA P{sev-sgg.T} NA characterization construct P{mini10} NA P{mini39} NA P{mini46} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}sggEP1379 NA P{EP}sggEP1576 NA P{EPgy2}sggEY02862 NA P{Mae-UAS.6.11}sggGG01041 NA P{Mae-UAS.6.11}sggGG01088 NA P{Mae-UAS.6.11}sggGG01196 NA P{Mae-UAS.6.11}sggGG01441 NA P{Mae-UAS.6.11}sggGG01840 NA P{XP}sggd00428 NA P{XP}sggd01056 NA P{XP}sggd03640 NA P{XP}sggd03768 NA P{XP}sggd04069 NA P{XP}sggd04107 NA P{XP}sggd04342 NA P{XP}sggd07627 NA P{XP}sggd07708 NA P{XP}sggd10160 NA miscellaneous insertions P{PTT-GA}sggCA06683 NA P{PTT-GA}sggG138 NA P{PTT-un1}sggG00015 NA P{PTT-un1}sggG33 NA P{PTT-un1}sggPT004 NA P{PTT-un1}sggZCL1626 NA P{RS3}sggCB-5590-3 NA P{RS5}sgg5-SZ-3093 NA P{SUPor-P}sggKG01982 NA P{SUPor-P}sggKG02219 NA P{SUPor-P}sggKG02594 NA P{SUPor-P}sggKG08704 NA PBac{566.P.SVS-1}sggCPTI100027 NA PBac{602.P.SVS-1}sggCPTI000023 NA PBac{602.P.SVS-1}sggCPTI000854 NA PBac{681.P.FSVS-1}sggCPTI001231 NA PBac{769.FSVS-1}sggCPTI002603 NA PBac{HpaI-GFP.A}sggYD0060 NA PBac{WH}sggf00462 NA PBac{WH}sggf04468 NA PBac{WH}sggf07311 NA insertion of enhancer trap binary system Mi{ET1}sggMB03827 No P{GawB}sggNP0082 No P{GawB}sggNP0085 No P{GawB}sggNP0122 No P{GawB}sggNP0626 No P{GawB}sggNP0715 No P{GawB}sggNP2253 No P{GawB}sggNP4101 No P{GawB}sggNP7142 No P{GawB}sggNP7167 No P{GawB}sggNP7270 No P{GawB}sggtwkr No insertion of enhancer trap P{lacW}sggG0055 No P{lacW}sggG0183 No P{lacW}sggG0263 No P{lacW}sggG0335 No P{lacW}sggPL36 No P{PZ}sggJC05 No
Gene Ontology: Function, Process & Cellular Component ( 50 unique terms )
Terms Based on Experimental Evidence ( 38 terms )
Molecular Function
CV term Evidence References
kinase activity inferred from direct assay (Kanuka et al., 2005) protein binding inferred from physical interaction with Axn (Kremer et al., 2010) inferred from physical interaction with UniProtKB:O16844 (assigned by UniProtKB) (Zhang et al., 2005) protein kinase activity inferred from direct assay (Price and Kalderon, 2002)
Biological Process
CV term Evidence References
chitin-based larval cuticle pattern formation inferred from mutant phenotype (Kaplan et al., 2009) circadian rhythm inferred from mutant phenotype (Martinek et al., 2001) entrainment of circadian clock inferred from mutant phenotype (Yuan et al., 2005) epithelial cell morphogenesis inferred from genetic interaction with aPKC (Kaplan et al., 2011) inferred from mutant phenotype (Kaplan et al., 2011) establishment of epithelial cell planar polarity inferred from genetic interaction with aPKC (Kaplan et al., 2011) inferred from mutant phenotype (Kaplan et al., 2011) female meiosis inferred from mutant phenotype (Takeo et al., 2012) habituation inferred from mutant phenotype (Wolf et al., 2007) imaginal disc-derived wing morphogenesis inferred from mutant phenotype (Buratovich and Wilder, 2001) negative regulation of JUN kinase activity inferred from mutant phenotype (Franciscovich et al., 2008) negative regulation of smoothened signaling pathway inferred from direct assay (Price and Kalderon, 2002) inferred from mutant phenotype (Jia et al., 2002) negative regulation of synaptic growth at neuromuscular junction inferred from mutant phenotype (Franciscovich et al., 2008) olfactory learning inferred from mutant phenotype (Wolf et al., 2007) oogenesis inferred from mutant phenotype (Song and Xie, 2003) ovarian follicle cell development inferred from mutant phenotype (Jordan et al., 2006) positive regulation of mitotic metaphase/anaphase transition inferred from mutant phenotype (Wojcik, 2008) positive regulation of proteasomal ubiquitin-dependent protein catabolic process inferred from direct assay (Galletti et al., 2009) positive regulation of protein catabolic process inferred from mutant phenotype (Galletti et al., 2009) protein phosphorylation inferred from direct assay (Price and Kalderon, 2002, Jia et al., 2005) regulation of circadian rhythm inferred from mutant phenotype (Wolf et al., 2007) regulation of hemocyte differentiation inferred from mutant phenotype (Zettervall et al., 2004) regulation of proteolysis inferred from direct assay (Price and Kalderon, 2002) response to anesthetic inferred from mutant phenotype (Campbell et al., 2009) segment polarity determination inferred from mutant phenotype (Perrimon and Smouse, 1989) sensory organ development inferred from mutant phenotype (Kanuka et al., 2005) somatic stem cell maintenance inferred from mutant phenotype (Song and Xie, 2003) spindle organization inferred from mutant phenotype (Wojcik, 2008) synaptic growth at neuromuscular junction inferred from mutant phenotype (Franco et al., 2004) wing and notum subfield formation inferred from mutant phenotype (Mohit et al., 2006)
Cellular Component
CV term Evidence References
centrosome inferred from direct assay (Wojcik, 2008) inferred from direct assay (assigned by UniProtKB) (Bobinnec et al., 2006) cytoplasm inferred from direct assay (Wojcik, 2008) inferred from direct assay (assigned by UniProtKB) (Zhang et al., 2005) female germline ring canal inferred from direct assay (assigned by UniProtKB) (Bobinnec et al., 2006) fusome inferred from direct assay (Lighthouse et al., 2008) mitotic spindle inferred from direct assay (Wojcik, 2008) inferred from direct assay (assigned by UniProtKB) (Bobinnec et al., 2006) nucleoplasm inferred from direct assay (Wojcik, 2008) nucleus inferred from direct assay (Wojcik, 2008) inferred from direct assay (assigned by UniProtKB) (Zhang et al., 2005, Bobinnec et al., 2006)
Terms Based on Predictions or Assertions ( 14 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR017441 (FlyBase Curators et al., 2004-) protein serine/threonine kinase activity inferred from electronic annotation with InterPro:IPR008271 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Siegfried et al., 1990) non-traceable author statement (Morrison et al., 2000, Swiss-Prot Project Members, 1990.11.1)
Biological Process
CV term Evidence References
blastoderm segmentation non-traceable author statement (Swiss-Prot Project Members, 1990.11.1) chaeta morphogenesis non-traceable author statement (Sokolowski, 2001) circadian rhythm non-traceable author statement (Sokolowski, 2001) traceable author statement (Panda et al., 2002) heart development non-traceable author statement (Cripps and Olson, 2002) traceable author statement (Chen and Fishman, 2000) locomotor rhythm non-traceable author statement (Sokolowski, 2001) negative regulation of Wnt receptor signaling pathway traceable author statement (Marsh and Theisen, 1999) Notch signaling pathway traceable author statement (Martinez Arias, 2002) protein phosphorylation non-traceable author statement (Morrison et al., 2000) regulation of protein import into nucleus traceable author statement (Stanewsky, 2003) regulation of transcription, DNA-dependent non-traceable author statement (Swiss-Prot Project Members, 1990.11.1) rhythmic behavior traceable author statement (Stanewsky, 2003) Wnt receptor signaling pathway traceable author statement (Chen and Fishman, 2000)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	gene_with_edited_transcript (Graveley et al., 2011) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
sgg - Atx2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sgg - Axn anti tag coimmunoprecipitation, peptide massfingerprinting (Neumüller et al., 2012) sgg - B52 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sgg - CG10306 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sgg - CG11523 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) sgg - CG14786 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sgg - CG1910 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) sgg - CG2021 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sgg - CG3224 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sgg - CG3689 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sgg - CG3735 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sgg - CG4325 experimental knowledge based (Guruharsha et al., 2011) sgg - CG5568 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) sgg - CG6701 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sgg - CG7878 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sgg - Dgp-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sgg - Fmr1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sgg - Hsp23 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sgg - Imp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sgg - JhI-21 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sgg - Saf-B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sgg - SmD2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sgg - Srp54 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sgg - Synd anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) sgg - Syp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sgg - Zn72D anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sgg - bsf anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sgg - btz anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sgg - ci anti tag coimmunoprecipitation, anti tag western blot (Shi et al., 2011) sgg - cos anti tag coimmunoprecipitation, anti tag western blot (Shi et al., 2011) sgg - mRpL9 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sgg - mRpS28 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sgg - mod anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sgg - qkr54B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sgg - qkr58E-3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) sgg - r-l experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) sgg - vkg anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions sgg allele Gene References sgg1 scrib (Anholt et al., 2003) sgg32 cno (Miyamoto et al., 1995) N (Ramain et al., 2001) pan (Schweizer et al., 2003) Pka-C1 (Phillips et al., 1999) Su(fu) (Jia et al., 2002) sggA.hs wg (Cadigan and Nusse, 1996) sggEP1576 wg (Parker et al., 2002) sggM1-1 arm (Cox et al., 2000) sggM11 arm (Greaves et al., 1999, Tolwinski et al., 2003, Tolwinski and Wieschaus, 2004) fz (Zhang and Carthew, 1998) N (Brennan et al., 1999) nej (Waltzer and Bienz, 1998) nkd (Zeng et al., 2000) nmo (Zeng and Verheyen, 2004) sggS9A.Scer\UAS Axn (Collins and Treisman, 2000) brm (Collins and Treisman, 2000) eyg (Hazelett et al., 1998) mor (Collins and Treisman, 2000) osa (Collins and Treisman, 2000) wg (Collins and Treisman, 2000) sggScer\UAS.cSa Apc (Ahmed et al., 1998) mam (Helms et al., 1999) unspecified CG17278 (Mohit et al., 2006) cno (Yamamoto et al., 1997) cry (Stoleru et al., 2007) Cyp310a1 (Mohit et al., 2006) L (Singh et al., 2006, Singh et al., 2005) Nc (Kanuka et al., 2005) shg (Greaves et al., 1999) skn (Phillips et al., 1999)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 57779 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0003371 DroID - A comprehensive database of gene and protein interactions. • FBgn0003371 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31248 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • P18431
Orthologs
OrthoDB Orthologs (47) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6WH95F Dipteran inclusive ortholog search EOG64XJR6, EOG6GF3QZ Insect inclusive ortholog search EOG6R22Q2 Arthropod inclusive ortholog search EOG6Z34VV Metazoa inclusive ortholog search EOG6G7QRH
Orthologs in Drosophila Species (EOG6WH95F)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\sgg     Drosophila simulans   Dsim\GD24735     Drosophila sechellia   Dsec\GM16104     Drosophila sechellia   Dsec\GM19237     Drosophila erecta   Dere\GG12945     Drosophila ananassae   Dana\GF22237 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA22660     Drosophila persimilis   Dper\GL26894     Drosophila willistoni   Dwil\GK25068     Drosophila virilis   Dvir\GJ18748 Y   Drosophila mojavensis   Dmoj\GI14403 Y   Drosophila grimshawi   Dgri\GH24854 Y
Orthologs in non-Drosophila Dipterans (EOG64XJR6, EOG6GF3QZ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL005238 Y Anopheles gambiae Malaria mosquito  Agam\AGAP004443 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ006114 Y
Orthologs in non-Dipteran Insects (EOG6R22Q2)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB53394 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG027316 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH11757 Y Atta cephalotes Leafcutter ant  Acep\ACEP27325 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO19334 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL16074 Y Linepithema humile Argentine ant  Lhum\LH21036 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB21582 Y Solenopsis invicta Red fire ant  Sinv\SINV19282 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI005370 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI009257 Y Bombyx mori Silkmoth  Bmor\BGIBMGA008336 Y Pediculus humanus Human body louse  Phum\PHUM299450 Y Tribolium castaneum Red flour beetle  Tcas\sgg Y
Orthologs in non-Insect Arthropods (EOG6Z34VV)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\GSK-3B Y Ixodes scapularis Deer tick  Isca\ISCW009451 Y
Orthologs in non-Arthropod Metazoa (EOG6G7QRH)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\gsk-3 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_027914gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_009263gn Y Danio rerio Zebrafish  Drer\gsk3b Y Danio rerio Zebrafish  Drer\gsk3a Y Danio rerio Zebrafish  Drer\si:ch211-39e15.2 Y Danio rerio Zebrafish  Drer\si:dkeyp-80c12.7 Y Xenopus tropicalis Western clawed frog  Xtro\gsk3a Y Xenopus tropicalis Western clawed frog  Xtro\gsk3b Y Gallus gallus Domestic chicken  Ggal\GSK3B Y Mus musculus House mouse  Mmus\Gsk3b Y Mus musculus House mouse  Mmus\Gsk3a Y Rattus norvegicus Norway rat  Rnor\Gsk3a Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000002833 Y Homo sapiens Human  Hsap\GSK3A Y Homo sapiens Human  Hsap\GSK3B Y
Human Orthologs (2)
Gene OMIM HGNC Hsap\GSK3A     Hsap\GSK3B
AAA Orthologs (4) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila ananassae Dana\GF22237 Drosophila virilis Dvir\GJ18748 Drosophila mojavensis Dmoj\GI14403 Drosophila grimshawi Dgri\GH24854
Stocks & Reagents
Stocks Listed in FlyBase ( 59 )
Bloomington	5361 w1118; P{UAS-sgg.B}MB5 6818 w1118; P{UAS-sgg.S9E}2
Harvard	- P{XP}sggd00428 - P{XP}sggd01056 - P{XP}sggd03768 - P{XP}sggd07708 - P{XP}sggd10160 - PBac{WH}sggf00462 - PBac{WH}sggf04468 - PBac{WH}sggf07311
Kyoto	108186 w1118; P{UAS-sgg.B}MB5
VDRC	v101538 P{KK108994}VIE-260B
	More stocks available...
Genomic Clones ( 2 )
	BACR09H13 BACR30B01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 342 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP17592 LD44595 RE23481 RE68664 SD09379
Other clones	DPiM_LD44595 FI05468 FI18761 MIP03616 MIP20762
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT04276 GH06878 GH06978 GH16352 GM02018 GM24908 LD01918 LD03450 LD05145 LD06462 LD08734 LD09068 LD11601 LD11631 LD16931 LD17244 LD17827 LD18787 LD18850 LD20631 LD22702 LD23004 LD28670 LD32018 LD37479 LD44415 LD44665 LP02244 LP02411 LP14654 LP21266 RE04455 RE09090 RE11427 RE17270 RE18451 RE23445 RE35392 RE56813 RE57179 RE57889 RE63227 RE72754 RE74234 RH47561 SD06484 SD21404
Other clones	8831 9431 9833 29455 30926 33132 36513 53454 60217 61223 62195 65119 72931 73793 77550 81945 99424 101977 107476 108686 117344 118200 118725 144653 147266 147330 155599 157169 159869 162030 162851 162899 177210 178417 214319.46 214353.50 214371.59 214413.49 214441.55 214441.56 214577.35 522609 bs83b11 CK01.2A.D5 CK01.2C.E9 CK01.3D.F8 CK01.4A.E8 CK01.15B.H2 CK01.19A.C4 CK01.29B.G1 CK01.33D.C4 CK01.38A.G12 CK01.63A.F3 CK01.75B.H7 CK01.89A.E9 CK01.96A.D5 CK01.96A.D6 CK01.99B.E7 CK01.114C.E10 CK01.114C.F3 CK01.114C.F11 CK01.114C.H10 CK01.115C.G1 CK01.115D.D9 CK01.117A.F12 CK01.118D.G4 CK01.119A.D6 CK01.120D.B6 CK01.120D.C5 CK01.124D.F3 CK01.128D.G12 CK01.131A.D4 CK01.143B.F2 CK01.170C.E9 Dmel_neb_011984_0633_1576 EC052860 EC053347 EC053508 EC054837 EC055991 EC056287 EK028842 EK030032 EK039255 EK039363 EK040024 EK042044 EK063509 EK064428 EK069918 EK074615 EK074647 EK081003 EK089101 EK090158 EK090347 EK092411 EK092439 EK094822 EK099760 EK104714 EK108051 EK108651 EK109455 EK116353 EK137914 EK141239 EK143543 EK147350 EK153604 EK166342 EK170724 EK176823 EK182105 EK187115 EK187627 EK213050 EK216006 EK237946 EK248229 EK250435 EK250962 EK259238 EK260240 EK266339 EK266730 EK269509 EK282017 EK283637 EK298757 EP03215 EP05944 EP09258 EP10210 EP10223 EP11517 EP12155 EP13804 EP16006 ESG012a.E21_H06 FGM105H10 IP13037 LD07849 RP004014558 RP004032759 RP004036470 RP004056184 RP004063817 RP004072060 RP004078923 RP004081971 RP004082681 RP004084540 RP004084905 RP004090012 RP004102397 RP004106740 RP004106872 RP004108598 RP004112251 RP004113940 RP004123245 RP004124324 RP004131671 RP004145768 RP004148964 RP004150434 RP004155116 RP004157148 RP004158151 RP004160985 RP004171146 RP004173444 RP004191623 RP004192019 RP004192354 RP004193000 RP004194758 RP004195675 RP004196552 RP004201184 RP004202223 RP004202571 RP004204351 RP004205517 RP004205539 RP004208964 RP004210374 RP004210903 RP004212555 RP004214372 RP004217956 RP004224936 RP004226584 RP004231951 RP004232582 RP004233228 RP004233459 RP004234958 RP004236019 RP004236593 RP004238376 RP004241512 RP004242314 RP004247584 RP004248990 RP004251261 RP004251338 RP004251709 RP004252200 RP004253174 RP004253187 RP004253818 RP004255119 RP004255616 RP004261880 RP004267111 RP004274932 RP004298460 RP004303753 RP004308059 RP004313840 RP004327958 RP004331118 RP004332639 RP004339900 RP004341477 RP004348247 RP004356811 RP004357724 RP004358252 RP004360606 RP004362357 RP004367489 RP004372819 RP004375972 RP004381974 RP004383989 RP004388623 RP004394970 RP004397126 RP004399672 RP004400578 RP004400804 RP004416573 RP004427082 RP004433696 RP004437800 RP004441186 RP004443297 RP004443524 RP004454961 RP004458451 RP004460219 RP004468297 RP004471062 RP004472442 RP004474773 RP004477555 RP004480246 RP004486079 RP004488749 RP004495814 RP004501358 RP004502712 RP004506357 RP004511675 RP004512106 RP004515511 RP004515618 RP004515696 RP004518131 RP004519709 RP004522272 RP004523076 RP004524878 RP004528073 RP004531632 RP004531833 RP004534399 RP004541128 RP004541230 RP004546215 RP004548461 SD07535
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0003371 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31248
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: sgg CG2621 (Deng, 1999.11)
Source for database merge of	Source for merge of: sgg anon-WO03040301.254 (FlyBase, 1996-) Source for merge of: sgg l(1)G0263 l(1)G0335 l(1)G0183 l(1)G0055 (Peter et al., 2002)
Additional comments	The gskt gene may have been derived from the sgg gene by retroposition. (Dai et al., 2006) Source for merge of sgg anon-WO03040301.254 was sequence comparison (date:051113). (FlyBase, 1996-)
Other Comments
	Phosphorylation of Mad protein in the linker region by sgg regulates the development of sensory organs in the anterior-dorsal quadrant of the wing. (Quijano et al., 2011) sgg is cleaved from an inactive to an active form by Ark, Nc and Ice. The active sgg form inhibits macrochaeta formation. (Kanuka et al., 2005) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) 12 alleles of sgg been recovered in a screen for mutations with mutant phenotypes in clones in the wing. (Vegh and Basler, 2003) sgg has a role in the circadian clock. (Martinek et al., 2001) sgg has a role in tim phosphorylation and in regulated nuclear translocation of the per/tim heterodimer. (Martinek et al., 2001) Candidate gene for quantitative trait (QTL) locus determining bristle number. (Nuzhdin et al., 1999) sgg has a dual role in mesoderm development. It acts as an antagonist in cardiogenic wg signal transduction. It also seems to be required to promote positively the formation of the tin- and dpp-dependent "dorsal mesoderm", which is a prerequisite for cardiogenesis and visceral mesoderm formation. (Park et al., 1998) Overexpression of sgg blocks wg signaling in the embryonic midgut. (Steitz et al., 1998) sgg positively regulates dpp expression and negatively regulates wg expression in the imaginal discs. (Heslip et al., 1997) Planar polarity phenotypes of loss of function and overexpression of fz in the developing eye is studied, the phenotype is almost identical to overexpression of sgg. (Tomlinson et al., 1997) dsh and arm, but not sgg are required for heart formation. (Park et al., 1996) sgg mutations emulate the effects of high ubiquitous wg in the midgut. sgg, dsh and arm function to transmit the wg signal in the midgut in the same way as they do in the epidermis. Results suggest the wg signal transduction pathway acts in all three germ layers, the ectoderm, mesoderm and endoderm. (Yu et al., 1996) The sgg gene product is required for wg-dependent bristle inhibition. (Cadigan and Nusse, 1995) Variation of a microsatellite within the sgg locus has been studied in North American populations of D.melanogaster. (Goldstein and Clark, 1995) Clonal analysis shows that loss of sgg causes cells to adopt fates normally characteristic of wg-expressing cells and to interact with adjacent wild-type tissue to cause pattern duplications similar to those caused by ectopic wg expression. (Heslip et al., 1995) por is epistatic to sgg in the regulation of wg. (Manoukian et al., 1995) Genetic interactions suggest that cno participates with members of the N pathway in regulating adhesive cell-cell interactions for the determination of cell fate. (Miyamoto et al., 1995) sgg is part of a signalling pathway that is required for functions of post-embryonic development, including specification of peripheral sense organs. (Phillips and Whittle, 1995) sgg gene is indispensable for the transmission of the wg signal in distinct cells. (Wodarz and Nusse, 1995) sgg is required for normal specification or maintenance of regional identity in the developing wing blade. sgg may be involved in the wg pathway. sgg acts downstream of localised ap and wg expression to specify or maintain margin identity in the wing. (Blair, 1994) arm, dsh and sgg encode elements of a unique wg signalling pathway that is used several times throughout development. (Couso et al., 1994) wg acts through inactivation of the sgg protein kinase to specify ventral cell fate in the leg. (Diaz-Benjumea and Cohen, 1994) Direct wg autoregulation differs from wg signalling to adjacent cells in the importance of fu, smo and ci relative to sgg and arm. (Hooper, 1994) sgg is required for arm phosphorylation in vivo. (Peifer et al., 1994) Levels of cytoplasmic arm are regulated by sgg. Double mutant analysis demonstrates that arm functions downstream of wg and sgg. (Peifer et al., 1994) dsh and por act upstream of sgg, and arm acts downstream of sgg in the wg signalling pathway. dsh and por act upstream of sgg and arm acts downstream. (Siegfried et al., 1994) The sgg locus is structurally complex, encoding multiple proteins. Mutational analysis reveals a single complementation group, lethality of which is associated with the loss of two major sgg proteins. Phenotypes of flies expressing individual sgg proteins reveal some but not complete redundancy of function. Under experimental conditions, one form of the protein can carry out all known functions. (Ruel et al., 1993) Epistatic relationships indicate that sgg/'glycogen synthase kinase-3' is part of a signalling pathway downstream of N. (Ruel et al., 1993) wg and en expression patterns are studied in all known segment polarity mutants to investigate the requirement of other segment polarity genes in mediating the maintenance of wg and en. (van den Heuvel et al., 1993) Three classes of protein encoded by sgg have been characterised, A, B and C. The A form of sgg encodes the homologue of mammalian glycogen synthase kinase-3. (Siegfried et al., 1992) Genetic epistasis experiments indicate that wg signalling operates by inactivating the sgg repression of en autoregulation. sgg is epistatic to wg. (Siegfried et al., 1992) sgg is only required in cells expressing ac and sc. (Heitzler and Simpson, 1991) sgg has been molecularly characterised and mutant phenotypes described. (Siegfried et al., 1991) The sgg locus has been molecularly characterised. Sequence analysis suggests that sgg encodes a serine/threonine kinase. (Bourouis et al., 1990) Partial maternal insufficiency of sgg does not cause embryonic lethality. (Robbins, 1990) The sgg gene product displays homology to Ser-Thr protein kinases: sgg may play a role in a signal transduction pathway involved in the establishment of cell identity within each embryonic segment. (Siegfried et al., 1990) Clonal analysis has shown that ac and sc gene expression is unaltered in sgg mutants. Clusters of macrochaetae are caused by the differentiation of several bristles from each proneural cluster, sgg+ is necessary for the segregation of only one bristle mother cell within the cluster. (Simpson, 1990) The role of sgg during development has been studied. (Perrimon and Smouse, 1989) Larval growth protracted, ceasing in the first <up>sgg2, sgg9</up>, second sgg<up>5</up>, or third <up>sgg3 and sgg10</up> larval instar; death follows. sgg10 may survive to puparium formation. Mutant cuticle tissue survives only in tergites; lacks bristles and appears etched; some deformed mutant wing tissue also observed in sgg3. sgg3, but no other allele produces viable and fertile males in combination with Dp(1;4)wm65g (Shannon et al., 1972). sgg1 and sgg10 males exhibiting maternal-zygotic interaction with Dp(1;4)mg display deletion-mirror-image duplication homeotic transformation (eye-antenna, wing and leg discs) (Robbins, 1983). Same noted in male tissue of gynandromorphs (Kaufman), sgg9 and sgg10 (Garcia-Bellido and Robbins, 1983). More recent studies with sgg32, an amorphic allele, (Bourouis et al., 1989; Ripoll et al., 1988; Simpson et al., 1988; Simpson and Carteret, 1989) indicate that sgg is involved in the developmental choice between the epidermal pathway and that of the nervous system. In homozygous clones of sgg32 formed 48 h or more before puparium formation all trichomes are replaced by chaetae in the ratio of one chaeta to four trichomes reflecting the number of cells involved in the elaboration of each structure; chaetae formed conform to positional information and genotype; e.g., wing clones resemble dorsal or ventral costal bristles or triple or double row bristles depending on their position; clones are linear when near the margins and form clumps of chaetae when distant from the margins; adventitious veins often formed in association with wing clones. In the notum scutellar clones form macrochaetae in + but not sc genotypes and microchaetae in h but not + genotypes. Clones formed later than 48 h before puparium formation form trichomes, either more densely than normal (10-21 trichomes) or in normal density (up to 10 trichomes). sgg embryos from homozygous sgg female germ line cells exhibit delayed and disordered cellularization at blastoderm; gastrulation does not occur; no differentiation of ectoderm, mesoderm, or endoderm occurs; cell division continues and the embryo becomes filled with small round cells, most or all of which stain with neuronal-specific antibodies. sgg+ embryos from sgg female germinal tissue show nearly normal blastoderm formation and gastrulation; however they are short with complete cuticles and neural hyperplasia as seen in neurogenic mutants; a lawn of hairs is seen dorsally and ventrally most of the denticle belts are lacking. Two doses of sgg+ in such embryos lead to more nearly normal cuticular development, but with odd-numbered denticle bands appearing before even-numbered ones. sgg progeny of females that carry sgg+ in their germ lines die as defective larvae with underdeveloped central nervous systems; the degree of CNS development is positively correlated with the number of maternal doses of sgg+.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057366 NM_057367 NM_057368 NM_134278 NM_166947 NM_166948 NM_206611 NM_206612 NM_206613 NM_206614 NM_206615 NM_001042794 NM_001103400 NM_001169178 NM_001169179 NM_001272263 NM_001272264 RefSeq (Proteins) • NP_476714 NP_476715 NP_476716 NP_599105 NP_726822 NP_726823 NP_996334 NP_996335 NP_996336 NP_996337 NP_996338 NP_001036259 NP_001096870 NP_001162649 NP_001162650 NP_001259192 NP_001259193 DDBJ / EMBL / GenBank • AA801629 AAF45801 AAM50318 AAM52705 AAN09082 AAN09083 AAN09084 AAN09085 AAN09086 AAQ03098 AAQ03099 AAQ03100 AAQ03101 AAQ03102 AAQ03103 AAQ03104 AAQ03105 AAQ03106 AAQ03107 AAQ03108 AAQ03109 AAQ03110 AAQ03111 AAQ03112 AAQ03113 AAQ03114 AAQ03115 AAQ03116 AAQ03117 AAQ03118 AAQ03119 AAQ03120 AAQ03121 AAQ03122 AAQ03123 AAQ03124 AAQ03125 AAQ03126 AAQ03127 AAQ03128 AAQ03129 AAQ03130 AAQ03131 AAQ03132 AAQ03133 AAQ03134 AAQ03135 AAQ03136 AAQ03137 AAQ03138 AAQ03139 AAQ03140 AAQ03141 AAQ03142 AAQ03143 AAQ03144 AAQ03145 AAQ03146 AAQ03147 AAQ03148 AAQ03149 AAQ03150 AAS65252 AAS65253 AAS65254 AAS65255 AAS65256 ABI30966 ABW09331 ACZ95186 ACZ95187 AF404349 AF404350 AF404351 AF404352 AF404353 AF404354 AF404355 AF404356 AF404357 AF404358 AF404359 AF404360 AF404361 AF404362 AF404363 AF404364 AF404365 AF404366 AF404367 AF404368 AF404369 AF404370 AF404371 AF404372 AF404373 AF404374 AF404375 AF404376 AF404377 AF404378 AF404379 AF404380 AF404381 AF404382 AF404383 AF404384 AF404385 AF404386 AF404387 AF404388 AF404389 AF404390 AF404391 AF404392 AF404393 AF404394 AF404395 AF404396 AF404398 AF404399 AF404400 AF404401 AF404402 AGB95038 AGB95039 AI512665 AI542875 AJ300061 AJ300062 AJ300063 AJ300064 AL024485 AL034544 AL121804 AQ025509 AW943733 AW944593 AX777400 AY119664 AY122193 BH901065 CAA19676 CAA22520 CAA37419 CAA37951 CAA37952 CAA50212 CAA50213 CAA50214 CAA50215 CAA50216 CAB65860 CAB72296 CZ471595 CZ473480 CZ473541 CZ473542 CZ473738 CZ473875 CZ475881 CZ477131 CZ482934 CZ490127 X53332 X54005 X54006 X70862 X70863 X70864 X70865 X70866 Entrez Gene - A searchable database of RefSeq genes. • 31248 UniProtKB/Swiss-Prot • P18431 UniProtKB/TrEMBL • A4V3W1 A4V3W2 A8JUV9 C0PUX5 Q0KHW6 Q6A4R5 Q6A4R8 Q6A4S5 Q6A4T5 Q6A4T7 Q6A4W4 Q6A4W6 Q7KVY5
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Serine/threonine- / dual specificity protein kinase, catalytic domain (IPR002290) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • MIP03616
Linkouts
	BioGRID - A database of protein and genetic interactions • 57779 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0003371 DroID - A comprehensive database of gene and protein interactions. • FBgn0003371 DRSC - Results from RNAi screens. • FBgn0003371 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003371 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2621-RA;HDC17143;CG2621-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0003371 FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways • 101497 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31248 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /segment/shaggy.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31248 modMine - Data generated by the modENCODE project. • FBgn0003371 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • P18431
Synonyms & Secondary IDs ( 81 )
Reported As
Symbol Synonym	anon-WO03040301.254   CG2621 (Bourbon et al., 2002, Benos, 2000.12.13, Morrison et al., 2000, Whitfield, 2000.10.5, Juhola et al., 2000, Legube et al., 2006, Dai et al., 2006, Quinones-Coello, 2007, Keleman et al., 2009.8.5, Ni et al., 2008, Ni et al., 2011.7.19, Ni et al., 2010.12.1) DMSGG3 (Fernando Vazquez et al., 2000, Rand et al., 2000) Dmsgg3 (Lopez et al., 2002) DMZ3K25Z (Schug et al., 1998) Dm Zw3 (Konikoff et al., 2010) EG:155E2.3 (Benos, 2000.2.6, Benos et al., 2001, Benos, 2000.12.13, ) EG:BACR7C10.8   GSK (Bienz and Hamada, 2004, Zhang et al., 2005) GSK3 (Kalderon, 2002, Ou et al., 2003, Bienz and Clevers, 2003, Cripps and Olson, 2002, Bienz, 1999, Zervas et al., 1999, Welsh et al., 1996, Osterlund and Kogerman, 2006, Smelkinson and Kalderon, 2006, Heeg-Truesdell, 2006, Price et al., 2007, Tolwinski, 2007, Jia et al., 2005, Zhang et al., 2006, Torroja et al., 2005, Martin-Pena et al., 2006, Bakal et al., 2008, Smelkinson et al., 2007, Krejcí et al., 2009, Ko et al., 2010, Acebes et al., 2012) Gsk3 (He et al., 2004, Furlong, 2005, Rafel and Milán, 2008) GSK-3 (Marsh and Thompson, 2004, Ferkey and Kimelman, 2000, Smelkinson and Kalderon, 2006, Wolf et al., 2007) gsk3 (DasGupta et al., 2005) Gsk-3 (Dionne et al., 2006) GSK-3B (Colosimo and Tolwinski, 2008) GSK3Β (Yeh et al., 2010, Colosimo et al., 2010) GSK3β (Lum and Beachy, 2004, Ogden et al., 2004, Behrens, 2000, Peifer and Polakis, 2000, Yuan et al., 2005, Galletti et al., 2009, Mitchell et al., 2008, Zheng and Sehgal, 2010, Kaplan et al., 2009) GSK-3β (Zoghbi and Botas, 2002, Bienz, 2002, McCartney et al., 2001, Tountas and Fortini, 2007, French and Heberlein, 2009, Viquez et al., 2009, Franciscovich et al., 2008, Rao et al., 2008) GSK3-β (van Eyk et al., 2011) Gsk-3β (Patel and Hardy, 2012) GSK3β/SGG (Kim and Edery, 2006) GSK3βgr; (Chau et al., 2006) GSK-3βSgg (Bhandari and Shashidhara, 2001) GSKβ (Jones and Bejsovec, 2003) l(1)3Ba (The Moscow Regional Drosophila melanogaster Stock Center, Dubna, Wilkins and Gubb, 1991, ) l(1)G0055 (Schaefer et al., 1999.3.29, ) l(1)G0183 (Schaefer et al., 1999.12.10, ) l(1)G0263 (Schaefer et al., 1999.6.15, ) l(1)G0335 (Schaefer et al., 1999.8.12, ) l(1)zw3 (Chou and Perrimon, 1992, Robbins, 1990, Lin and Wolfner, 1989, Paradi et al., 1983, Garcia-Bellido and Robbins, 1983, Lim and Snyder, 1974, Shannon et al., 1972, ) Sgg (Sousa-Neves et al., 2001, Mohit et al., 2006, Torroja et al., 2005, Sofola et al., 2010, Mitchell et al., 2008, Chatterjee et al., 2009, Buechling et al., 2011) sgg (Singh et al., 2006, Quinones-Coello et al., 2007, Ishii, 2005, Legent et al., 2012, Diangelo and Birnbaum, 2009, Buszczak et al., 2007, Nybakken et al., 2005, Cyran et al., 2005, Quinones-Coello, 2007, Jordan et al., 2006, Mirkovic et al., 2011, Stoleru et al., 2007, Weaver and Goldstein, 2008, Papadopoulou et al., 2004, Marques, 2005, Fang et al., 2007, Vosshall, 2007, Gan et al., 2010, Nawathean et al., 2007, Wolf et al., 2007, Hayward et al., 2006, Kankel et al., 2007, Knowles-Barley et al., 2010, Devineni et al., 2011, Folwell et al., 2010, French and Heberlein, 2009, Galletti et al., 2009, Schmidt et al., 2008, Zhou et al., 2011, Lin et al., 2010, Muñoz-Descalzo et al., 2011, Abruzzi et al., 2011, Morris et al., 2008, Morris et al., 2012, Toku et al., 2011, DeFalco et al., 2008, Ruel et al., 2007, Ataman et al., 2008, Zeng et al., 2008, Miech et al., 2008, Lear et al., 2005, Franciscovich et al., 2008, Terriente et al., 2008,