Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.45
4.9 (northern blot)
None of the polypeptides share 100% sequence identity.
Heterotetramer of potassium channel proteins.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Shaw using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Shaw in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Shaw CG2822
Source for merge of: Shaw CG15419
Annotations CG2822 and CG15419 merged as CG2822 in release 3 of the genome annotation.
Studying channel expression in Xenopus oocytes suggests a discrete site within the protein is the primary locus of alcohol and general anaesthetic action.
Shaw encodes a 42 pS noninactivating K+ channel present in embryonic neurons, that has extremely low voltage sensitivity.
Yeast two-hybrid system studies demonstrate the association of the hydrophilic N-terminal domains of the genes encoding channel proteins plays an important role in determining the specificity of α subunit association to form heteromultimeric potassium channels.
The blockade of Shaw channels by ethanol and halothane supports the protein hypothesis of anaesthesia.
Although Sh, Shal, Shab and Shaw proteins share a conserved structral organisation, their potassium channel currents (expressed in Xenopus oocytes) differ greatly in individual kinetic properties and voltage sensitivity.
Sh, Shal, Shab and Shaw encode voltage gated potassium channels with widely varying kinetics (rate of macroscopic current activation and inactivation) and voltage sensitivity of steady state inactivation.
Potassium channel diversity could result from an extended gene family as well as from alternate splicing of the Sh primary transcript.
In Xenopus oocyte mRNA injection experiment, protein encoded by Shaw transcripts leads to potassium currents with slow activation and inactivation kinetics (Wei et al., 1990a; Wei et al., 1990b).