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FB2025_05
,
released December 11, 2025
Shaw2, dShaw2
Please see the JBrowse view of Dmel\Shaw for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.45
4.9 (northern blot)
None of the polypeptides share 100% sequence identity.
498 (aa)
56.5 (kD predicted)
Heterotetramer of potassium channel proteins.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Shaw using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Shaw transcripts are detected in late embryos, pupae and adults but not in early embryos on northern blots.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Shaw in JBrowse2-11
2-9.3
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Studying channel expression in Xenopus oocytes suggests a discrete site within the protein is the primary locus of alcohol and general anaesthetic action.
Shaw encodes a 42 pS noninactivating K+ channel present in embryonic neurons, that has extremely low voltage sensitivity.
Yeast two-hybrid system studies demonstrate the association of the hydrophilic N-terminal domains of the genes encoding channel proteins plays an important role in determining the specificity of α subunit association to form heteromultimeric potassium channels.
The blockade of Shaw channels by ethanol and halothane supports the protein hypothesis of anaesthesia.
Potassium channel diversity could result from an extended gene family as well as from alternate splicing of the Sh primary transcript.
In Xenopus oocyte mRNA injection experiment, protein encoded by Shaw transcripts leads to potassium currents with slow activation and inactivation kinetics (Wei et al., 1990a; Wei et al., 1990b).
Source for merge of: Shaw CG15419
Annotations CG2822 and CG15419 merged as CG2822 in release 3 of the genome annotation.
Source for identity of: Shaw CG2822
