FB2019_06, released Dec 19, 2019

Gene: Dmel\shd

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General Information
Symbol
Dmel\shd
Species
D. melanogaster
Name
shade
Annotation Symbol
CG13478
Feature Type
protein_coding_gene
FlyBase ID
FBgn0003388
Gene Model Status
Current
Stock Availability
7 publicly available
Enzyme Name (EC)
Ecdysone 20-monooxygenase (1.14.99.22)
Gene Snapshot
shade (shd) encodes 20-hydroxylase and is responsible for converting Ecdysone into 20-hydroxyecdysone, the active form of the steroid. It is required in all tissues that produce active Ecdysone and thus contributes to larval moulting, metamorphosis, growth, neuroblast diversity and egg chamber maturation. [Date last reviewed: 2018-09-13]
Other Summaries
Also Known As
Cyp314a1
Key Links
Genomic Location
Cytogenetic map
70E4-70E4
Sequence location
3L:14,614,458..14,622,205 [+]
Recombination map
3-42
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the cytochrome P450 family. (Q9VUF8)
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
ecdysone 20-monooxygenase activity
Predictions / Assertions
heme binding; iron ion binding
Catalytic Activity (EC)
Experimental Evidence
Ecdysone + AH(2) + O(2) = 20-hydroxyecdysone + A + H(2)O (1.14.99.22)
Predictions / Assertions
-
Summaries
Gene Group (FlyBase)
HALLOWEEN CYTOCHROMES P450 -
The Halloween genes are members of the cytochrome P450 superfamily of enzymes involved the ecdysteroid biosynthetic pathway identified from embryonic lethal mutants. (Adapted from FBrf0204727 and FBrf0201926).
Protein Function (UniProtKB)
Required for CNS development; midline glial cells. Involved in the metabolism of insect hormones; responsible for all ecdysone 20-monooxygenase activity during embryonic, larval and adult stages. May be involved in the breakdown of synthetic insecticides.
(UniProt, Q9VUF8)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
shd: shade
Embryonic lethal. No differentiation of cuticle or head skeleton.
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
2

Please see the GBrowse view of Dmel\shd or the JBrowse view of Dmel\shd for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.46
Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
shd-RB
FBtr0075676
NM_206352
2730
540
shd-RC
FBtr0304700
NM_140452
1633
433
shd-RD
FBtr0333031
NM_001274914
2985
540
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
shd-PB
FBpp0089324
61.7
540
7.09
NP_996074
AAS65010
shd-PC
FBpp0293243
49.0
433
5.02
NP_648709
AAF49727
shd-PD
FBpp0305245
61.7
540
7.09
NP_001261843
AGB94536
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

540 aa isoforms: shd-PB, shd-PD
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\shd using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (13 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
ecdysone 20-monooxygenase activity
inferred from direct assay
(Petryk et al., 2003)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
heme binding
inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002401
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
iron ion binding
inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002401
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Biological Process (9 terms)
Terms Based on Experimental Evidence (8 terms)
CV Term
Evidence
References
border follicle cell migration
inferred from mutant phenotype
(Domanitskaya et al., 2014)
central nervous system development
inferred from mutant phenotype
(Giesen et al., 2003)
dorsal closure
inferred from mutant phenotype
(Giesen et al., 2003, Petryk et al., 2003)
ecdysteroid biosynthetic process
inferred from direct assay
(Petryk et al., 2003)
inferred from mutant phenotype
(Petryk et al., 2003)
growth of a germarium-derived egg chamber
inferred from mutant phenotype
(Petryk et al., 2003)
head involution
inferred from mutant phenotype
(Giesen et al., 2003)
midgut development
inferred from mutant phenotype
(Petryk et al., 2003)
pupation
inferred from mutant phenotype
(Akagi et al., 2016)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
oxidation-reduction process
inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002401, InterPro:IPR017972
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
mitochondrion
inferred from direct assay
(Petryk et al., 2003)
Terms Based on Predictions or Assertions (0 terms)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
mitochondrion
inferred from direct assay
(Petryk et al., 2003)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\shd in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 11-12
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 7 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of shd
Transgenic constructs containing regulatory region of shd
Deletions and Duplications ( 6 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal - all die before end of embryonic stage
lethal - all die before end of embryonic stage | recessive
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4twi.2PE, shd1/shd2
viable (with shd1), with Scer\GAL4twi.2PE, shdUAS.cPa
viable (with shd2), with Scer\GAL4twi.2PE, shdUAS.cPa
Sterility
Allele
female semi-fertile, with Scer\GAL4GMR47A04
female sterile, with Scer\GAL4twi.2PE, shd1/shd2
female sterile (with shd1), with Scer\GAL4twi.2PE, shdUAS.cPa
female sterile (with shd2), with Scer\GAL4twi.2PE, shdUAS.cPa
Other Phenotypes
Allele
developmental rate defective | prepupal stage, with Scer\GAL4C855a
developmental rate defective | prepupal stage, with Scer\GAL4Cg.PA
developmental rate defective | prepupal stage, with Scer\GAL4elav.PLu
developmental rate defective | prepupal stage, with Scer\GAL4how-24B
developmental rate defective | prepupal stage, with Scer\GAL4Mef2.PR
some die during embryonic stage
some die during embryonic stage | recessive
Phenotype manifest in
Allele
border follicle cell | somatic clone
cephalopharyngeal skeleton
commissure
egg chamber, with Scer\GAL4twi.2PE, shd1/shd2
egg chamber (with shd1), with Scer\GAL4twi.2PE, shdUAS.cPa
egg chamber (with shd2), with Scer\GAL4twi.2PE, shdUAS.cPa
embryo | dorsal closure stage
embryo | embryonic stage 14
embryonic/first instar larval cuticle
embryonic/larval cuticle
embryonic/larval foregut
embryonic/larval hindgut
embryonic/larval midgut
embryonic/larval midgut primordium
embryonic/larval tracheal system
embryonic dorsal epidermis
embryonic epidermis
embryonic head
embryonic midgut constriction
embryonic ventral epidermis
epicuticle
glial cell
midline glial cell | ectopic
presumptive embryonic/larval central nervous system
presumptive embryonic/larval peripheral nervous system
sensory neuron | embryonic stage
ventral nerve cord
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (7)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\CYP24A1
3 of 15
Yes
No
Hsap\CYP11A1
2 of 15
No
No
Hsap\CYP11B1
2 of 15
No
No
Hsap\CYP11B2
2 of 15
No
No
Hsap\CYP27A1
2 of 15
No
No
Hsap\CYP27B1
2 of 15
No
No
Hsap\CYP27C1
2 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (6)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Cyp24a1
3 of 15
Yes
No
Mmus\Cyp11a1
2 of 15
No
No
Mmus\Cyp11b1
2 of 15
No
No
Mmus\Cyp11b2
2 of 15
No
No
Mmus\Cyp27a1
2 of 15
No
No
Mmus\Cyp27b1
2 of 15
No
No
Rattus norvegicus (Norway rat) (11)
Rnor\Cyp11a1
2 of 13
Yes
No
Rnor\Cyp11b2
2 of 13
Yes
Yes
Rnor\Cyp11b3
2 of 13
Yes
No
Rnor\Cyp24a1
2 of 13
Yes
No
Rnor\Cyp27a1
2 of 13
Yes
No
Rnor\Cyp27b1
2 of 13
Yes
No
Rnor\Cyp11b1
1 of 13
No
Yes
Rnor\LOC680316
1 of 13
No
Yes
Rnor\LOC100909462
1 of 13
No
Yes
Rnor\LOC100910462
1 of 13
No
Yes
Rnor\LOC102557389
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (10)
Xtro\cyp11a1
2 of 12
Yes
No
Xtro\cyp24a1
2 of 12
Yes
No
Xtro\cyp27a1
2 of 12
Yes
No
Xtro\cyp27b1
2 of 12
Yes
No
Xtro\cyp27c1
2 of 12
Yes
Yes
Xtro\LOC100145331
2 of 12
Yes
No
Xtro\LOC594905
1 of 12
No
Yes
Xtro\LOC100496109
1 of 12
No
Yes
Xtro\LOC100496967
1 of 12
No
Yes
Xtro\LOC101731070
1 of 12
No
Yes
Danio rerio (Zebrafish) (12)
Drer\cyp11a2
2 of 15
Yes
No
Drer\cyp24a1
2 of 15
Yes
No
Drer\cyp27a1.2
2 of 15
Yes
No
Drer\cyp27a1.4
2 of 15
Yes
No
Drer\cyp27a7
2 of 15
Yes
No
Drer\cyp27b1
2 of 15
Yes
No
Drer\cyp27c1
2 of 15
Yes
No
Drer\si:ch211-113j14.1
2 of 15
Yes
No
Drer\si:dkey-91i10.3
2 of 15
Yes
No
Drer\zgc:136333
2 of 15
Yes
No
Drer\cyp11a1
1 of 15
No
No
Drer\cyp11c1
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (3)
Cele\cyp-44A1
2 of 15
Yes
No
Cele\cyp-33D1
1 of 15
No
No
Cele\cyp-35B3
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (4)
Atha\CYP71A12
1 of 9
Yes
No
Atha\CYP705A1
1 of 9
Yes
Yes
Atha\CYP707A4
1 of 9
Yes
Yes
Atha\CYP712A1
1 of 9
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\DIT2
1 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091905SJ )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\shd
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00004066
Drosophila simulans
Dsim\GD14493
Drosophila sechellia
Dsec\GM25470
Drosophila erecta
Dere\GG15687
Drosophila yakuba
Dyak\GE22018
Drosophila ananassae
Dana\GF24608
Drosophila pseudoobscura pseudoobscura
Dpse\GA12315
Drosophila persimilis
Dper\GL21018
Drosophila willistoni
Dwil\GK10527
Drosophila virilis
Dvir\GJ13686
Drosophila mojavensis
Dmoj\GI11492
Drosophila grimshawi
Dgri\GH14751
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915032G )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17019279
Glossina morsitans
Tsetse fly
Gmor\GMOY009748
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_09700
Mayetiola destructor
Hessian fly
Mdes\Mdes009958
Aedes aegypti
Yellow fever mosquito
Aaeg\CYP314A1
Anopheles darlingi
American malaria mosquito
Adar\ADAC008743
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W02US )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA010239
Danaus plexippus
Monarch butterfly
Dple\DPOGS205009-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL009457
Apis florea
Little honeybee
Aflo\2154237924
Apis mellifera
Western honey bee
Amel\GB45651
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP18931
Bombus terrestris
Buff-tailed bumblebee
Bter\15216558
Linepithema humile
Argentine ant
Lhum\LH23107
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0026ba
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG020286
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_02868
Tribolium castaneum
Red flour beetle
Tcas\CYP314A1
Pediculus humanus
Human body louse
Phum\PHUM213010
Rhodnius prolixus
Kissing bug
Rpro\RPRC006945
Cimex lectularius
Bed bug
Clec\CLEC008635
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI009813
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI083788
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI008228
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_02808
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X07RT )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR006062
Ixodes scapularis
Black-legged tick
Isca\ISCW021011
Ixodes scapularis
Black-legged tick
Isca\ISCW001527
Stegodyphus mimosarum
African social velvet spider
Smim\KFM62388.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur03g03020
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_198743
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G08AT )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Ciona intestinalis
Vase tunicate
Cint\LOC100178411
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (41)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
dib
5 of 10
Cyp12a4
4 of 10
Cyp12c1
4 of 10
Cyp12a5
3 of 10
Cyp12b2
3 of 10
Cyp12d1-d
3 of 10
Cyp12d1-p
3 of 10
Cyp12e1
3 of 10
Cyp49a1
3 of 10
Cyp301a1
3 of 10
sad
3 of 10
Cyp6a2
1 of 10
Cyp6a8
1 of 10
Cyp6a9
1 of 10
Cyp6a13
1 of 10
Cyp6a17
1 of 10
Cyp6a18
1 of 10
Cyp6a19
1 of 10
Cyp6a21
1 of 10
Cyp6a22
1 of 10
Cyp6a23
1 of 10
Cyp6d2
1 of 10
Cyp6d4
1 of 10
Cyp6d5
1 of 10
Cyp6g1
1 of 10
Cyp6g2
1 of 10
Cyp6t1
1 of 10
Cyp6t3
1 of 10
Cyp6v1
1 of 10
Cyp6w1
1 of 10
Cyp9b1
1 of 10
Cyp9b2
1 of 10
Cyp9c1
1 of 10
Cyp9f2
1 of 10
Cyp9h1
1 of 10
Cyp28a5
1 of 10
Cyp28c1
1 of 10
Cyp28d1
1 of 10
Cyp28d2
1 of 10
Cyp309a1
1 of 10
Cyp309a2
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    CYP24A1; cytochrome P450 family 24 subfamily A member 1
    3 of 15
    126065
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      esyN Network Diagram
      Show neighbor-neighbor interactions:
      Select Layout:
      Legend:
      Protein
      RNA
      Selected Interactor(s)
      Interactions Browser
      View in Interactions Browser
      Please see the Physical Interaction reports below for full details
      protein-protein
      Physical Interaction
      Assay
      References
      shd - CCT6
      experimental knowledge based
      (Guruharsha et al., 2011)
      shd - CCT8
      experimental knowledge based
      (Guruharsha et al., 2011)
      Summary of Genetic Interactions
      esyN Network Diagram
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      External Data
      Linkouts
      DroID - A comprehensive database of gene and protein interactions.
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      External Data
      Linkouts
      KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      3L
      Recombination map
      3-42
      Cytogenetic map
      70E4-70E4
      Sequence location
      3L:14,614,458..14,622,205 [+]
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      70E4-70E4
      Limits computationally determined from genome sequence between P{PZ}Mpcp00564 and P{PZ}l(3)rO220rO220
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      70E4-70E5
      (Dunkov, 2000.6.29)
      Experimentally Determined Recombination Data
      Location
      3-42
      (FlyBase, 2016)
      3-36.3
      (Comeron et al., 2012)
      3-41
      (Tearle and Nusslein-Volhard, 1987)
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (7)
      Genomic Clones (19)
       

      Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

      cDNA Clones (10)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequences
      BDGP DGC clones
      Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of
        Source for database merge of
        Source for merge of: shd Cyp314a1
        (Petryk, 2002.2.15)
        Additional comments
        Other Comments
        Four EMS induced alleles have been identified in a screen for mutations affecting commissure formation in the CNS of the embryo.
        (Hummel et al., 1999)
        shd mutants display no differentiation of the cuticle or head skeleton.
        (Jurgens et al., 1984)
        Origin and Etymology
        Discoverer
        Etymology
        Identification
        External Crossreferences and Linkouts ( 40 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        modMine - A data warehouse for the modENCODE project
        Linkouts
        DPiM - Drosophila Protein interaction map
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        FlyMine - An integrated database for Drosophila genomics
        KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Synonyms and Secondary IDs (10)
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        References (86)