General Information
Symbol
Dmel\shi
Species
D. melanogaster
Name
shibire
Annotation Symbol
CG18102
Feature Type
FlyBase ID
FBgn0003392
Gene Model Status
Stock Availability
Gene Snapshot
In progress.Contributions welcome.
Also Known As
Dyn, shibire, dynamin
Genomic Location
Cytogenetic map
Sequence location
X:15,892,116..15,906,716 [+]
Recombination map
1-52
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
GO Summary Ribbons
Families, Domains and Molecular Function
Gene Group Membership (FlyBase)
Protein Family (UniProt, Sequence Similarities)
Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (P27619)
Molecular Function (see GO section for details)
Experimental Evidence
Predictions / Assertions
Summaries
UniProt Contributed Function Data
Microtubule-associated force-producing protein which is involved in the production of microtubule bundles and which is able to bind and hydrolyze GTP. Implicated in endocytic protein sorting.
(UniProt, P27619)
Phenotypic Description from the Red Book (Lindsley and Zimm 1992)
shi: shibire (C. A. Poodry)
The shibire locus is characterized by its temperature-sensitive alleles, which are reversibly paralyzed by exposure to 29, but are essentially normal at 22 (Grigliatti et al.). Exposure of developing animals to the restrictive temperature for pulses of one to several hours leads to a plethora of developmental defects, which are specific for the stage treated (Poodry, Hall, and Suzuki, 1973, Dev. Biol. 66: 442-56) (see following table). Short exposures to restrictive temperatures at the time of delamination of the neuroblasts from the neurogenic ectoderm leads to excess neurogenesis at the expense of epidermogenesis, as seen in the neurogenic mutants (Poodry, 1990, Dev. Biol., in press). Differentiation of myoblasts and neuroblasts is inhibited in shi1 embryonic cells in vitro at 30 (Buzin, Dewhurst, and Seecof, 1978, Dev. Biol. 66: 442-56). Embryonic neurons cultured at 30 show reduced adhesion to the substrate, retardation of growth cone formation and suppressed neuron formation and elongation; reversed by shift to permissive temperature (Kim and Wu, 1987, J. Neurosci. 7: 3245-55). Lethal embryos disorganized by the restrictive temperature can be cultured in vivo as tumorous masses (Poodry). Eye-antenna discs can also be cultured as tumorous masses for several transfer generations (Williams, 1981, DIS 56: 158-61). Primary in vivo culture of cut leg imaginal discs leads to an exceptionally high rate of transdetermination (Poodry).
            

temperature-
sensitive period               developmental phenotype
_________________________________________________________________________
1.5-3 hr                       loss of pole cells
3-4 hr                         fusion of cell membranes leading
                               to syncytium
5-12 hr                        disorganized proliferation of cells
                               leading to transplantable tumorous
                               masses
late third instar              stubby legs; joints missing;
  12 hr heat pulse             clipped wings
48 hr before pupariation       eye scar (loss of pigment cells
                               and cone cells).  The later the
                               heat pulse, the more anterior the
                               position of the scar on eye
pupariation to pupation        animals die and fail to undergo
                               pupation
14-24 hr after pupariation     supernumerary microchaetae on head
                               and thorax; the temperature sensitive
                               period for each bristle site precedes
                               the final cell division of bristle
                               precursor; loss of macrochaetae on
                               head and thorax.  Disruption of giant-
                               fiber pathway development (Hummon and
                               Costello, 1987, J. Neurosci. 7:  3633-38).
                               Reduced numbers of dorsal-longitudinal
                               flight muscles (Hummon and Costello,
                               1988, Roux's Arch. Dev. Biol.
                               197:  383-93)
24-36 hr after pupariation     loss of head and thoracic micro-
                               chaetae; supernumerary abdominal
                               macrochaetae and microchaetae
28-42 hr after pupariation     loss of abdominal macrochaetae
                               and microchaetae
32-48 hr after pupariation     loss of abdominal microchaetae
48 hr after pupariation        scimitar-shaped bristles
adult                          eggs fail to mature

            
            
The temperature-sensitive alleles differ in the severity of their paralysis, recovery period, the restrictive temperature for developmental effects, and in their viability as hemizygotes. They are all hypomorphs, being recessive and having a more extreme expression in combination with a deficiency than when homozygous. A wild-type paternal gene can rescue an egg from a homozygous mother only after 10 hr of development (Swanson and Poodry, 1976, Dev. Biol. 48: 205-11). Of the developmental effects tested, all are autonomous in mosaics generated by somatic recombination or in gynandromorphs (Poodry). The developmental effects on bristles is not enhanced or suppressed by the presence of temperature-sensitive alleles of N; shi is epistatic to N (Lujan, 1981, DIS 56: 86). Physiological studies of shi have revealed the loss of transients in electroretinograms (Kelley and Suzuki, 1974, Proc. Nat. Acad. Sci. USA 71: 4906-09) and failure of neuromuscular transmission at the restrictive temperature (Ikeda, Ozawa, and Hagiwara, 1976, Nature 259: 489-91; Siddiqi and Benzer, 1976, Proc Nat. Acad. Sci. USA 73: 3253-57), though axonal conduction and muscle membrane excitability are unimpaired (Ikeda et al.). Exposure of shi1 adults to 29 causes the depletion of synaptic vesicles from the neuromuscular synapse and their replacement with large cisternae (Poodry and Edgar, 1979, J. Cell Biol. 81: 520-27; Koenig, Saito, and Ikeda, 1983, J. Cell Biol. 96: 1517-22). Accumulation of acetyl choline is reduced at the restrictive temperature, not because of reduced synthesis but because of an abnormally rapid rate of release from the cell, which is not reduced by inhibiting tetrodotoxin-sensitive nerve activity (Wu, Merneking, and Barker, 1983, J. Neurochem. 40: 1386-96). Endocytosis is reversibly blocked in the nerve terminus (Kosaka and Ikeda, 1983, Neurobiol. 14: 207-25; Masur, Kim, and Wu, 1990, J. Neurosci.) and may limit the ability of nerves to regenerate synaptic vesicles. Neuromuscular transmission temperature is sensitive in mosaics in which the neuron but not the muscle is mutant, but not in the converse situation (Koenig and Ikeda, 1983, J. Neurobiol. 14: 411-19). During recovery from exposure to 30 shits1 muscles display a multimodal distribution of miniature excitatory junction potential amplitudes never seen in wild type (Ikeda and Koenig, 1987, J. Physiol. 406: 215-23). Further, as the temperature is increased the amplitude of evoked excitatory junction potentials decreases; the numbers of vesicles per synapse displays a correlated decrease (Koenig, Kosaka, and Ikeda, 1989, J. Neurosci. 9: 1937-42). Endocytosis is also blocked in the garland cells (Kosaka and Ikeda, 1983, J. Cell Biol. 97: 499-507). Vesiculation of cell membranes results in fusion of blastoderm cells (Swanson and Poodry, 1981, Dev. Biol. 84: 465-70) and vesiculation of surface membranes accompanies secretion of protein epicuticle (Poodry).
Gene Model and Products
Number of Transcripts
15
Number of Unique Polypeptides
7

Please see the GBrowse view of Dmel\shi or the JBrowse view of Dmel\shi for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.52
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated.
Gene model reviewed during 5.46
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.50
Gene model reviewed during 5.55
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0074121
3990
830
FBtr0074118
4180
830
FBtr0074119
3878
830
FBtr0074122
3991
830
FBtr0074123
3191
877
FBtr0074124
3190
877
FBtr0111036
4309
830
FBtr0111037
4321
830
FBtr0301594
3380
877
FBtr0301595
3300
877
FBtr0301596
3096
883
FBtr0301597
4198
836
FBtr0333717
3712
896
FBtr0333718
4768
834
FBtr0340413
3667
881
Additional Transcript Data and Comments
Reported size (kB)
5.1, 4.3 (northern blot)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0089278
93.0
830
8.43
FBpp0073928
93.0
830
8.43
FBpp0073929
93.0
830
8.43
FBpp0089279
93.0
830
8.43
FBpp0089280
97.8
877
8.58
FBpp0089277
97.8
877
8.58
FBpp0110335
93.0
830
8.43
FBpp0110336
93.0
830
8.43
FBpp0290809
97.8
877
8.58
FBpp0290810
97.8
877
8.58
FBpp0290811
98.5
883
8.43
FBpp0290812
93.7
836
8.26
FBpp0305866
99.9
896
8.87
FBpp0305867
93.5
834
8.08
FBpp0309359
98.3
881
8.26
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

830 aa isoforms: shi-PA, shi-PB, shi-PC, shi-PE, shi-PH, shi-PI
877 aa isoforms: shi-PF, shi-PG, shi-PJ, shi-PK
Additional Polypeptide Data and Comments
Reported size (kDa)
883, 836 (aa); 100 (kD observed)
Comments
A form of shi protein which localizes predominantly to the body. This form lacks 6aa inserted at the first alternate splice site (Alt1) that are present in the "head" form of the protein. An antibody to shi was generated in mouse that reacts primarily with the body form of shi protein. This difference supports the existence of different brain and body forms but the differential immunoreactivity could not be completely explained by the splicing variants identified here.
A form of shi protein which localizes predominantly to the head. This form includes 6aa inserted at the first alternate splice site (Alt1) that are absent in the "body" form of the protein.
alternative 3' exon
External Data
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\shi using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (66 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
non-traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN000170013
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000170013
(assigned by GO_Central )
Biological Process (49 terms)
Terms Based on Experimental Evidence (45 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from direct assay
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
inferred from direct assay
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:jar; FB:FBgn0011225
inferred from mutant phenotype
Terms Based on Predictions or Assertions (10 terms)
CV Term
Evidence
References
traceable author statement
traceable author statement
traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN000170172
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000902093
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000170172
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000902093
(assigned by GO_Central )
Cellular Component (14 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
inferred from mutant phenotype
Terms Based on Predictions or Assertions (11 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000170172
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000170013
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000902092
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000170172
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000170172
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000170013
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000902092
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000170172
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000170172
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000170172
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000170172
(assigned by GO_Central )
Expression Data
Transcript Expression
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
shi protein is found in the presynaptic membrane in neuromuscular junctions in wandering third instar larvae.
Marker for
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
inferred from mutant phenotype
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\shi in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, Transgenic Constructs and Phenotypes
Classical and Insertion Alleles ( 69 )
For All Classical and Insertion Alleles Show
 
Allele of shi
Class
Mutagen
Associated Insertion
Stocks
Known lesion
    0
    --
      0
      --
        0
        --
          0
          --
            0
            --
              0
              --
                0
                --
                Other relevant insertions
                Transgenic Constructs ( 28 )
                For All Alleles Carried on Transgenic Constructs Show
                Transgenic constructs containing/affecting coding region of shi
                Allele of shi
                Mutagen
                Associated Transgenic Construct
                Stocks
                Transgenic constructs containing regulatory region of shi
                characterization construct
                Name
                Expression Data
                Deletions and Duplications ( 15 )
                Summary of Phenotypes
                For more details about a specific phenotype click on the relevant allele symbol.
                Lethality
                Allele
                Other Phenotypes
                Allele
                Phenotype manifest in
                Allele
                abdominal 2 ventral longitudinal muscle & larval somatic muscle | conditional ts
                actin filament & spermatid | conditional ts
                adherens junction & wing cell | pupal stage | conditional - heat sensitive
                axon & eye photoreceptor cell | conditional - heat sensitive, with Scer\GAL4GMR.PF
                eye photoreceptor cell & ommatidium | ectopic
                garland cell & endosome
                glial cell & brain & pupa | conditional ts, with Scer\GAL4repo
                larval somatic muscle & presynaptic membrane | conditional ts
                larval somatic muscle & synaptic vesicle | conditional ts
                macrochaeta & thorax | conditional ts
                mesothoracic tergum & macrochaeta
                microchaeta & thorax | conditional ts
                photoreceptor cell & synaptic vesicle
                wing & macrochaeta
                Orthologs
                Human Orthologs (via DIOPT v7.1)
                Homo sapiens (Human) (6)
                Species\Gene Symbol
                Score
                Best Score
                Best Reverse Score
                Alignment
                Complementation?
                Transgene?
                14 of 15
                Yes
                Yes
                13 of 15
                No
                Yes
                 
                13 of 15
                No
                Yes
                4 of 15
                No
                No
                 
                1 of 15
                No
                Yes
                1 of 15
                No
                Yes
                Model Organism Orthologs (via DIOPT v7.1)
                Mus musculus (laboratory mouse) (4)
                Species\Gene Symbol
                Score
                Best Score
                Best Reverse Score
                Alignment
                Complementation?
                Transgene?
                15 of 15
                Yes
                Yes
                12 of 15
                No
                Yes
                12 of 15
                No
                Yes
                3 of 15
                No
                No
                Rattus norvegicus (Norway rat) (6)
                10 of 13
                Yes
                Yes
                9 of 13
                No
                Yes
                9 of 13
                No
                Yes
                4 of 13
                No
                No
                1 of 13
                No
                Yes
                1 of 13
                No
                Yes
                Xenopus tropicalis (Western clawed frog) (4)
                7 of 12
                Yes
                Yes
                6 of 12
                No
                Yes
                4 of 12
                No
                Yes
                2 of 12
                No
                No
                Danio rerio (Zebrafish) (16)
                14 of 15
                Yes
                Yes
                13 of 15
                No
                Yes
                12 of 15
                No
                Yes
                11 of 15
                No
                Yes
                4 of 15
                No
                No
                3 of 15
                No
                Yes
                1 of 15
                No
                Yes
                1 of 15
                No
                No
                1 of 15
                No
                Yes
                1 of 15
                No
                Yes
                1 of 15
                No
                Yes
                1 of 15
                No
                Yes
                1 of 15
                No
                Yes
                1 of 15
                No
                Yes
                Caenorhabditis elegans (Nematode, roundworm) (2)
                15 of 15
                Yes
                Yes
                3 of 15
                No
                No
                Arabidopsis thaliana (thale-cress) (10)
                2 of 9
                Yes
                No
                2 of 9
                Yes
                No
                1 of 9
                No
                Yes
                1 of 9
                No
                Yes
                1 of 9
                No
                Yes
                1 of 9
                No
                Yes
                1 of 9
                No
                Yes
                1 of 9
                No
                Yes
                1 of 9
                No
                Yes
                1 of 9
                No
                Yes
                Saccharomyces cerevisiae (Brewer's yeast) (3)
                5 of 15
                Yes
                No
                4 of 15
                No
                No
                3 of 15
                No
                Yes
                Schizosaccharomyces pombe (Fission yeast) (3)
                3 of 12
                Yes
                No
                3 of 12
                Yes
                No
                2 of 12
                No
                Yes
                Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091902QY )
                Organism
                Common Name
                Gene
                AAA Syntenic Ortholog
                Multiple Dmel Genes in this Orthologous Group
                Drosophila melanogaster
                fruit fly
                Drosophila suzukii
                Spotted wing Drosophila
                Drosophila simulans
                Drosophila sechellia
                Drosophila erecta
                Drosophila yakuba
                Drosophila ananassae
                Drosophila persimilis
                Drosophila willistoni
                Drosophila virilis
                Drosophila mojavensis
                Drosophila grimshawi
                Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501BC )
                Organism
                Common Name
                Gene
                Multiple Dmel Genes in this Orthologous Group
                Musca domestica
                House fly
                Glossina morsitans
                Tsetse fly
                Lucilia cuprina
                Australian sheep blowfly
                Mayetiola destructor
                Hessian fly
                Aedes aegypti
                Yellow fever mosquito
                Anopheles darlingi
                American malaria mosquito
                Anopheles gambiae
                Malaria mosquito
                Culex quinquefasciatus
                Southern house mosquito
                Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0147 )
                Organism
                Common Name
                Gene
                Multiple Dmel Genes in this Orthologous Group
                Danaus plexippus
                Monarch butterfly
                Heliconius melpomene
                Postman butterfly
                Apis florea
                Little honeybee
                Apis florea
                Little honeybee
                Apis mellifera
                Western honey bee
                Bombus impatiens
                Common eastern bumble bee
                Bombus terrestris
                Buff-tailed bumblebee
                Bombus terrestris
                Buff-tailed bumblebee
                Linepithema humile
                Argentine ant
                Megachile rotundata
                Alfalfa leafcutting bee
                Nasonia vitripennis
                Parasitic wasp
                Dendroctonus ponderosae
                Mountain pine beetle
                Dendroctonus ponderosae
                Mountain pine beetle
                Tribolium castaneum
                Red flour beetle
                Pediculus humanus
                Human body louse
                Rhodnius prolixus
                Kissing bug
                Cimex lectularius
                Bed bug
                Acyrthosiphon pisum
                Pea aphid
                Zootermopsis nevadensis
                Nevada dampwood termite
                Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X012G )
                Organism
                Common Name
                Gene
                Multiple Dmel Genes in this Orthologous Group
                Strigamia maritima
                European centipede
                Ixodes scapularis
                Black-legged tick
                Stegodyphus mimosarum
                African social velvet spider
                Stegodyphus mimosarum
                African social velvet spider
                Stegodyphus mimosarum
                African social velvet spider
                Stegodyphus mimosarum
                African social velvet spider
                Tetranychus urticae
                Two-spotted spider mite
                Daphnia pulex
                Water flea
                Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0EIQ )
                Organism
                Common Name
                Gene
                Multiple Dmel Genes in this Orthologous Group
                Strongylocentrotus purpuratus
                Purple sea urchin
                Strongylocentrotus purpuratus
                Purple sea urchin
                Ciona intestinalis
                Vase tunicate
                Gallus gallus
                Domestic chicken
                Gallus gallus
                Domestic chicken
                Gallus gallus
                Domestic chicken
                Human Disease Model Data
                FlyBase Human Disease Model Reports
                Alleles Reported to Model Human Disease (Disease Ontology)
                Download
                Models ( 1 )
                Allele
                Disease
                Evidence
                References
                model of  collagen disease
                inferred from mutant phenotype
                Interactions ( 5 )
                Allele
                Disease
                Interaction
                References
                ameliorates  epilepsy
                Comments ( 0 )
                 
                Human Orthologs (via DIOPT v7.1)
                Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
                Functional Complementation Data
                Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                Interactions
                Summary of Physical Interactions
                esyN Network Diagram
                Show neighbor-neighbor interactions:
                Select Layout:
                Legend:
                Protein
                RNA
                Selected Interactor(s)
                Interactions Browser

                Please look at the Interaction Group reports for full details of the physical interactions
                protein-protein
                Interacting group
                Assay
                References
                Summary of Genetic Interactions
                esyN Network Diagram
                esyN Network Key:
                Suppression
                Enhancement

                Please look at the allele data for full details of the genetic interactions
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                External Data
                Linkouts
                BioGRID - A database of protein and genetic interactions.
                DroID - A comprehensive database of gene and protein interactions.
                InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                Pathways
                Gene Group - Pathway Membership (FlyBase)
                External Data
                Linkouts
                Genomic Location and Detailed Mapping Data
                Chromosome (arm)
                X
                Recombination map
                1-52
                Cytogenetic map
                Sequence location
                X:15,892,116..15,906,716 [+]
                FlyBase Computed Cytological Location
                Cytogenetic map
                Evidence for location
                13F18-13F18
                Limits computationally determined from genome sequence between P{EP}Gβ13FEP1071 and P{EP}EP1458&P{EP}EP1522
                Experimentally Determined Cytological Location
                Cytogenetic map
                Notes
                References
                13F-14A
                (determined by in situ hybridisation)
                14A-14A
                (determined by in situ hybridisation)
                13F16-14A1
                (determined by in situ hybridisation)
                Determined by comparing Celera genomic sequence with sequence from BDGP BAC and P1 clones.
                Experimentally Determined Recombination Data
                Location
                1-51.5
                Left of (cM)
                Right of (cM)
                Notes
                Stocks and Reagents
                Stocks (39)
                Genomic Clones (19)
                cDNA Clones (187)
                 

                Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                cDNA clones, fully sequences
                BDGP DGC clones
                Other clones
                  Drosophila Genomics Resource Center cDNA clones

                  For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                  cDNA Clones, End Sequenced (ESTs)
                  RNAi and Array Information
                  Linkouts
                  DRSC - Results frm RNAi screens
                  GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                  Antibody Information
                  Laboratory Generated Antibodies
                  Commercially Available Antibodies
                   
                  Other Information
                  Relationship to Other Genes
                  Source for database identify of
                  Source for database merge of
                  Source for merge of: shi CG18102
                  Source for merge of: shi anon-WO0153538.12 anon-WO0153538.13 anon-WO0153538.14
                  Additional comments
                  Source for merge of shi anon-WO0153538.12 anon-WO0153538.13 anon-WO0153538.14 was sequence comparison ( date:051113 ).
                  Other Comments
                  shi is required to coordinate recruitment of Clathrin and AP2 during synaptic vesicle formation.
                  dsRNA made from templates generated with primers directed against shi profoundly promotes the wg-signaling pathway.
                  dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
                  RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 and S2R+ cells: binucleate cells.
                  Dl is not endocytosed in shi mutants.
                  shi dependent retrieval of secreted sog protein is required for formation of the sog protein gradient across the dorsal side of the blastoderm embryo.
                  A P{UAS-shits1.K} transgene has been used to show that synaptic transmission from mushroom body neurons is required during memory retrieval but not during acquisition or storage.
                  shi has a role in maintaining normal heart function.
                  shi mutants have been used to show that there are two functionally and topographically distinct pools of synaptic vesicles, exo/endo cycling and reserve pools.
                  Fluorescent Ca-sensitive dye, Ca Crimson, is used to monitor presynaptic Ca dynamics.
                  In presynaptic terminals α-Adaptin defines a network-like membrane structure to which the GTPase dynamin is recruited. α-Adaptin is necessary for the formation of clathrin coated pits and participates in the dynamin-dependent release of coated vesicles from the membrane surface. Results suggest an α-Adaptin-dependent control of the vesicle cycle that maintains the balance between the amount of vesicle- and surface-associated membranes.
                  Overexpression of different constitutively active forms of N in shi mutant flies indicates that shi function is not necessary for transduction of the signal downstream of N, even when the receptor, N, is integrated in the plasma membrane. When wild-type N is activated by its ligand Dl, shi is required in both signaling and receiving cells for normal singling out of precursors.
                  The structure of the protein encoded by the second, stnB ORF suggests a possible role in membrane trafficking, allowing an interpretation of the interaction seen between the various 'stoned' and shi mutants.
                  The two isoforms of dynamin detected in wild type and shi mutants are associated with two different pellet fractions of head homogenates. At least one isoform is membrane-associated. Normal distribution of dynamin is not affected by heat shock, block of the GTP cycle or the presence of stabilised microtubules in wild type or shi mutants. Results suggest the two isoforms are likely to be involved in separate cellular compartments rather than different functional states in the same membrane-cycling pathway.
                  Recycling of synaptic vesicle proteins is blocked in temperature sensitive mutants of shi. Similar inhibition of dye uptake is also seen. Vesicle recycling after the block can occur in the absence of extracellular calcium. BWSV induces calcium-independent exocytosis at nerve terminals. It is most likely that calcium is required for the endocytic recycling of synaptic vesicles.
                  shi gene product is thought to provide the motor for vesicular transport during endocytosis.
                  Mosaic analysis within muscles demonstrates the developmental focus of the shi mutant phenotype is the muscle itself. The normal shi function, endocytosis, is essential in muscle tissue during a sensitive stage of myogenesis in early pupae.
                  Mutations at stnA show allele-specific interactions with mutations at dnc and shi. A suppressor of stnA, Su(stn) has been identified. The stnA gene product interacts directly or indirectly with the cAMP second messenger system, synaptic membrane recycling pathway and with biogenic amine metabolism.
                  Expression of shi is particularly high in CNS and PNS throughout neuronal development.
                  The shi locus encodes Drosophila dynamin.
                  shi has been cloned and sequenced.
                  Studies of the neuromuscular junctions of heat-treated shi1 flies indicate that paralysis is associated with loss of synaptic vesicles. Examination of the neurogenic region of the embryos reveals numerous packets of extracellular vesicles and coated pits blocked in endocytosis.
                  The shibire locus is characterized by its temperature-sensitive alleles, which are reversibly paralyzed by exposure to 29oC, but are essentially normal at 22oC (Grigliatti, Hall, Rosenbluth and Suzuki, 1973). Exposure of developing animals to the restrictive temperature for pulses of one to several hours leads to a plethora of developmental defects, which are specific for the stage treated (Poodry, Hall and Suzuki, 1973) (see shi1 allele record. Short exposures to restrictive temperatures at the time of delamination of the neuroblasts from the neurogenic ectoderm leads to excess neurogenesis at the expense of epidermogenesis, as seen in the neurogenic mutants (Poodry, 1990). Differentiation of myoblasts and neuroblasts is inhibited in shi1 embryonic cells in vitro at 30oC (Buzin, Dewhurst and Seecof, 1978). Embryonic neurons cultured at 30oC show reduced adhesion to the substrate, retardation of growth cone formation and suppressed neuron formation and elongation; reversed by shift to permissive temperature (Kim and Wu, 1987). Lethal embryos disorganized by the restrictive temperature can be cultured in vivo as tumorous masses (Poodry). Eye-antenna discs can also be cultured as tumorous masses for several transfer generations (Williams, 1981). Primary in vivo culture of cut leg imaginal discs leads to an exceptionally high rate of transdetermination (Poodry). The temperature-sensitive alleles differ in the severity of their paralysis, recovery period, the restrictive temperature for developmental effects and in their viability as hemizygotes. They are all hypomorphs, being recessive and having a more extreme expression in combination with a deficiency than when homozygous. A wild-type paternal gene can rescue an egg from a homozygous mother only after 10 hr of development (Swanson and Poodry, 1976). Of the developmental effects tested, all are autonomous in mosaics generated by somatic recombination or in gynandromorphs (Poodry). The developmental effects on bristles is not enhanced or suppressed by the presence of temperature-sensitive alleles of N; shi is epistatic to N (Lujan, 1981). Physiological studies of shi have revealed the loss of transients in electroretinograms (Kelley and Suzuki, 1974) and failure of neuromuscular transmission at the restrictive temperature (Ikeda, Ozawa and Hagiwara, 1976; Siddiqi and Benzer, 1976), though axonal conduction and muscle membrane excitability are unimpaired (Ikeda, Ozawa and Hagiwara, 1976). Exposure of shi1 adults to 29oC causes the depletion of synaptic vesicles from the neuromuscular synapse and their replacement with large cisternae (Poodry and Edgar, 1979; Koenig, Saito and Ikeda, 1983). Accumulation of acetyl choline is reduced at the restrictive temperature, not because of reduced synthesis but because of an abnormally rapid rate of release from the cell, which is not reduced by inhibiting tetrodotoxin-sensitive nerve activity (Wu, Merneking and Barker, 1983). Endocytosis is reversibly blocked in the nerve terminus (Kosaka and Ikeda, 1983a; Masur, Kim and Wu, 1990) and may limit the ability of nerves to regenerate synaptic vesicles. Neuromuscular transmission temperature is sensitive in mosaics in which the neuron but not the muscle is mutant, but not in the converse situation (Koenig and Ikeda, 1983b). During recovery from exposure to 30oC shi1 muscles display a multimodal distribution of miniature excitatory junction potential amplitudes never seen in wild type (Ikeda and Koenig, 1987). Further, as the temperature is increased the amplitude of evoked excitatory junction potentials decreases; the numbers of vesicles per synapse displays a correlated decrease (Koenig, Kosaka and Ikeda, 1989). Endocytosis is also blocked in the garland cells (Kosaka and Ikeda, 1983a). Vesiculation of cell membranes results in fusion of blastoderm cells (Swanson and Poodry, 1981) and vesiculation of surface membranes accompanies secretion of protein epicuticle (Poodry).
                  Origin and Etymology
                  Discoverer
                  Grigliatti, 1971.
                  Etymology
                  "shibire" means "paralysed" in Japanese.
                  Identification
                  External Crossreferences and Linkouts ( 130 )
                  Crossreferences
                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                  UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                  UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                  Linkouts
                  BioGRID - A database of protein and genetic interactions.
                  Drosophila Genomics Resource Center - Drosophila Genomics Resource Center cDNA clones
                  DroID - A comprehensive database of gene and protein interactions.
                  DRSC - Results frm RNAi screens
                  Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                  FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                  FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                  Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                  Flygut - An atlas of the Drosophila adult midgut
                  FlyMine - An integrated database for Drosophila genomics
                  GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                  iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                  Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                  InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                  KEGG Genes - Molecular building blocks of life in the genomic space.
                  modMine - A data warehouse for the modENCODE project
                  Synonyms and Secondary IDs (23)
                  Reported As
                  Symbol Synonym
                  anon-WO0153538.12
                  anon-WO0153538.13
                  anon-WO0153538.14
                  l(1)VII
                  l(1)shi
                  shi
                  (Al-Ramahi et al., 2018, Ameku et al., 2018, Lee et al., 2018, Meiselman et al., 2018, Salazar and Yamamoto, 2018, Spéder and Brand, 2018, Yamazaki et al., 2018, Zhao et al., 2018, Zhou et al., 2018, Bussmann and Storkebaum, 2017, Herzmann et al., 2017, Kamalesh et al., 2017, Osterfield et al., 2017, Park et al., 2017, Fang et al., 2016, Gene Disruption Project members, 2016-, Lycette et al., 2016, Malartre, 2016, Meehan et al., 2016, Nagy et al., 2016, Neyen et al., 2016, Peters and Berg, 2016, Romani et al., 2016, Vogt et al., 2016, Farkaš et al., 2015, Gene Disruption Project members, 2015-, Grotewiel and Bettinger, 2015, Hunter et al., 2015, Jia et al., 2015, Kroll et al., 2015, Legent et al., 2015, Lin et al., 2015, Liu et al., 2015, Tonoki and Davis, 2015, Van Bortle et al., 2015, Zang et al., 2015, Zirin et al., 2015, Acharya et al., 2014, Aso et al., 2014, Haelterman et al., 2014.3.25, Issman-Zecharya and Schuldiner, 2014, Karuppudurai et al., 2014, Kasprowicz et al., 2014, Lin et al., 2014, Meier et al., 2014, Otsuna et al., 2014, Parsons et al., 2014, Roy et al., 2014, Schottenfeld-Roames et al., 2014, Tasdemir-Yilmaz and Freeman, 2014, Titlow et al., 2014, Vijayan et al., 2014, Vogt et al., 2014, Wang et al., 2014, Wu et al., 2014, Yamamoto et al., 2014, Bräcker et al., 2013, Bulgakova et al., 2013, Devineni et al., 2013, Fan et al., 2013, Gross et al., 2013, Kwon et al., 2013, Kwon et al., 2013, Lin et al., 2013, Peters et al., 2013, Riemensperger et al., 2013, Silies et al., 2013, Su et al., 2013, Sun and Spradling, 2013, Teodoro et al., 2013, Terriente-Felix et al., 2013, Truong Quang et al., 2013, van den Brink et al., 2013, Winther et al., 2013, Yamamoto et al., 2013, Yamamoto et al., 2013-, Yamanaka et al., 2013, Belozerov et al., 2012, Berni et al., 2012, Boulanger et al., 2012, Burke et al., 2012, Chen et al., 2012, Couturier et al., 2012, Dottermusch-Heidel et al., 2012, Ishida et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Jean et al., 2012, Johnson et al., 2012, Kaun et al., 2012, Keleman et al., 2012, Legent et al., 2012, Lieu et al., 2012, Luo and Sehgal, 2012, Noebels et al., 2012, Rodriguez et al., 2012, Sakai et al., 2012, Starostina et al., 2012, Stevens et al., 2012, Sudhakaran et al., 2012, Wernet et al., 2012, Zhou et al., 2012, Zhou et al., 2012, Al-Hasan et al., 2011, Burke and Waddell, 2011, Callejo et al., 2011, Crisp et al., 2011, Friedman et al., 2011, Halbsgut et al., 2011, Han et al., 2011, Huang et al., 2011, Inada et al., 2011, Kaun et al., 2011, Kazama et al., 2011, Keene et al., 2011, Koon et al., 2011, Lee et al., 2011, Lone et al., 2011, Mateus et al., 2011, Neely et al., 2011, Ng et al., 2011, Pinal and Pichaud, 2011, Pitman et al., 2011, Séjourné et al., 2011, Sorribes et al., 2011, Sousa-Nunes et al., 2011, Stümpges and Behr, 2011, Trannoy et al., 2011, Uytterhoeven et al., 2011, Wigby et al., 2011, Xu et al., 2011, Yamada et al., 2011, Yang et al., 2011, Yuva-Aydemir et al., 2011, Alekseyenko et al., 2010, Benhra et al., 2010, Chen et al., 2010, Dason et al., 2010, Gong et al., 2010, Grygoruk et al., 2010, Hebbar and Fernandes, 2010, Ho et al., 2010, Houalla et al., 2010, Hsouna et al., 2010, Kahsai et al., 2010, Kamikouchi et al., 2010, Keene et al., 2010, Kim et al., 2010, Koganezawa et al., 2010, Kopyl et al., 2010, Kopyl et al., 2010, Larkin et al., 2010, Li et al., 2010, Liu et al., 2010, Liu et al., 2010, Nahm et al., 2010, Negreiros et al., 2010, Nojima et al., 2010, Pauls et al., 2010, Pauls et al., 2010, Pirraglia et al., 2010, Popodi et al., 2010-, Quinones et al., 2010, Saja et al., 2010, Silies and Klämbt, 2010, Tiklová et al., 2010, Vijayakrishnan et al., 2010, Wasbrough et al., 2010, Wasbrough et al., 2010, Windler and Bilder, 2010, Yamaguchi et al., 2010, Yarali and Gerber, 2010, Yuan et al., 2010, Zars, 2010, Zhang et al., 2010, Zhang et al., 2010, Desai et al., 2009, Doherty et al., 2009, Gonzalez-Bellido et al., 2009, Häsemeyer et al., 2009, Honjo and Furukubo-Tokunaga, 2009, Joseph et al., 2009, Katsuki et al., 2009, Kilman et al., 2009, Krashes et al., 2009, Kumar et al., 2009, Kuronen et al., 2009, Li et al., 2009, Loevenich et al., 2009, Nikolaev et al., 2009, Peralta et al., 2009, Pouille et al., 2009, Raghu et al., 2009, Sakai et al., 2009, Seugnet et al., 2009, Soukup et al., 2009, van Swinderen et al., 2009, Venken et al., 2009, Wülbeck et al., 2009, Xia and Chiang, 2009, Yan et al., 2009, Yang et al., 2009, Yao et al., 2009, Zimmermann et al., 2009, Barnes et al., 2008, Belenkaya et al., 2008, Callejo et al., 2008, Chang et al., 2008, Chen et al., 2008, Das et al., 2008, Gao et al., 2008, Gao et al., 2008, Georgiou et al., 2008, Honjo et al., 2008, Hoyer et al., 2008, Kasprowicz et al., 2008, Kimura et al., 2008, Lee et al., 2008, Leibfried et al., 2008, Mehnert and Cantera, 2008, Nallamothu et al., 2008, O'Connor-Giles et al., 2008, Rodal et al., 2008, Seugnet et al., 2008, Shiraiwa, 2008, Sokac and Wieschaus, 2008, Vaccari et al., 2008, Windler and Bilder, 2008, Xi et al., 2008, Xu et al., 2008, Zhang et al., 2008, Zhao et al., 2008, Zhou et al., 2008, Acevedo et al., 2007, Bakal et al., 2007, Baker et al., 2007, Beramendi et al., 2007, Dietzl et al., 2007, Han et al., 2007, Hsouna et al., 2007, Hughes and Thomas, 2007, Huntwork and Littleton, 2007, Kicheva et al., 2007, Koenig and Ikeda, 2007, Krashes et al., 2007, Ohyama et al., 2007, Rikhy et al., 2007, Rister et al., 2007, Roy et al., 2007, Sasaki et al., 2007, Song et al., 2007, Su et al., 2007, Tsarouhas et al., 2007, Wu et al., 2007, Xia and Tully, 2007, Zhang et al., 2007, Akalal et al., 2006, Bokel et al., 2006, Callejo et al., 2006, Delwig et al., 2006, Dickman, 2006, Gallet et al., 2006, Hennig et al., 2006, Huang et al., 2006, Keene et al., 2006, Kochubey et al., 2006, Kvitsiani and Dickson, 2006, Majumdar et al., 2006, Meyer et al., 2006, Molnar et al., 2006, Pai et al., 2006, Pirraglia et al., 2006, Pitman et al., 2006, Poskanzer et al., 2006, Rister and Heisenberg, 2006, Rives et al., 2006, Sakai and Kitamoto, 2006, Schmid et al., 2006, Seto and Bellen, 2006, Thum et al., 2006, Classen et al., 2005, Ghosh-Roy et al., 2005, Honjo and Furukubo-Tokunaga, 2005, Jekely et al., 2005, Klose et al., 2005, Koenig and Ikeda, 2005, Mathew et al., 2005, Mathew et al., 2005, Narayanan et al., 2005, Roegiers et al., 2005, Verstreken et al., 2005, Wu et al., 2005, Cherry and Perrimon, 2004, Cronin et al., 2004, Davis, 2004, Gerber et al., 2004, Keene et al., 2004, Trotta et al., 2004, Wang et al., 2004, Ye et al., 2004, Dubnau et al., 2003, Guha et al., 2003, Hall, 2003, van Swinderen and Greenspan, 2003, Chen et al., 2002, Kitamoto, 2002, Kitamoto, 2002, Rogat and Miller, 2002, Rohrbough and Broadie, 2002, Schwaerzel et al., 2002, Stewart et al., 2002, Kitamoto, 2001, Estes et al., 2000, Kawasaki et al., 2000, Robertson et al., 2000, Poodry, 1980)
                  Name Synonyms
                  shibire
                  (Meiselman et al., 2018, Salazar and Yamamoto, 2018, Osterfield et al., 2017, Fang et al., 2016, Malartre, 2016, Peters and Berg, 2016, Aradhya et al., 2015, Hunter et al., 2015, Lee et al., 2015, Acharya et al., 2014, Roy et al., 2014, Schottenfeld-Roames et al., 2014, Skwarek et al., 2014, Tasdemir-Yilmaz and Freeman, 2014, Vijayan et al., 2014, Vogt et al., 2014, Wang et al., 2014, Aby et al., 2013, Calcagno et al., 2013, Fabrowski et al., 2013, Gross et al., 2013, Liu and Wilson, 2013, Peters et al., 2013, Yamamoto et al., 2013, de Vries and Clandinin, 2012, Ishida et al., 2012, Legent et al., 2012, Lieu et al., 2012, Sakai et al., 2012, Stevens et al., 2012, Zhou et al., 2012, Zhou et al., 2012, Burke and Waddell, 2011, Cammarato et al., 2011, Clark et al., 2011, Denker et al., 2011, Freeman et al., 2011, Gieger et al., 2011, Inada et al., 2011, Kaun et al., 2011, Lone et al., 2011, Neely et al., 2011, Pocha et al., 2011, Stümpges and Behr, 2011, Swetha et al., 2011, Van Swinderen and Andretic, 2011, Varma and Mishra, 2011, Wang et al., 2011, Alekseyenko et al., 2010, Benhra et al., 2010, Dason et al., 2010, Hebbar and Fernandes, 2010, Inagaki et al., 2010, Inagaki et al., 2010, Koganezawa et al., 2010, Kuromi et al., 2010, Li et al., 2010, McPhee et al., 2010, Murakami et al., 2010, Negreiros et al., 2010, Nojima et al., 2010, Potter et al., 2010, Potter et al., 2010, Potter et al., 2010, Vijayakrishnan et al., 2010, Wasbrough et al., 2010, Yamaguchi et al., 2010, Zhang et al., 2010, Zhang et al., 2010, Akbergenova and Bykhovskaia, 2009, Al-Anzi et al., 2009, Chiang et al., 2009, Desai et al., 2009, Fricke et al., 2009, Gonzalez-Bellido et al., 2009, Gupta et al., 2009, Honjo and Furukubo-Tokunaga, 2009, Joseph et al., 2009, Katsuki et al., 2009, Kilman et al., 2009, Krashes et al., 2009, Li et al., 2009, Nikolaev et al., 2009, Pouille et al., 2009, Raghu et al., 2009, Rajan et al., 2009, Seugnet et al., 2009, Tanaka et al., 2009, Vijayakrishnan et al., 2009, Vlisidou et al., 2009, Yang et al., 2009, Yao et al., 2009, Zimmermann et al., 2009, Belenkaya et al., 2008, Callejo et al., 2008, Chang et al., 2008, Chen et al., 2008, Das et al., 2008, Georgiou et al., 2008, Heerssen et al., 2008, Hoyer et al., 2008, Kasprowicz et al., 2008, Katsov and Clandinin, 2008, Lee and Sun, 2008, Leibfried et al., 2008, Nallamothu et al., 2008, Rodal et al., 2008, Seugnet et al., 2008, Shiraiwa, 2008, Sokac and Wieschaus, 2008, Xu et al., 2008, Zhao et al., 2008, Zhou et al., 2008, Behr et al., 2007, Beramendi et al., 2007, Han et al., 2007, Hsouna et al., 2007, Hughes and Thomas, 2007, Huntwork and Littleton, 2007, Ing et al., 2007, Koenig and Ikeda, 2007, Koh et al., 2007, Ohyama et al., 2007, Rikhy et al., 2007, Roy et al., 2007, Sasaki et al., 2007, Su et al., 2007, Tsarouhas et al., 2007, Zhang et al., 2007, Akalal et al., 2006, Bokel et al., 2006, Huang et al., 2006, Majumdar et al., 2006, Meyer et al., 2006, Pai et al., 2006, Rister and Heisenberg, 2006, Sakai and Kitamoto, 2006, Schmid et al., 2006, Seto and Bellen, 2006, Beronja et al., 2005, Dickman et al., 2005, Honjo and Furukubo-Tokunaga, 2005, Kelly and Phillips, 2005, Klose et al., 2005, Koenig and Ikeda, 2005, Narayanan et al., 2005, Wu et al., 2005, Cherry and Perrimon, 2004, Davis, 2004, Keene et al., 2004, Lecuit, 2004, Macleod et al., 2004, Trotta et al., 2004, Ye et al., 2004, Guha et al., 2003, Hall, 2003, van Swinderen and Greenspan, 2003, Chen et al., 2002, Kitamoto, 2002, Rogat and Miller, 2002, Rohrbough and Broadie, 2002, Kawasaki et al., 2000, Robertson et al., 2000, van der Bliek, 1991.5.15)
                  Secondary FlyBase IDs
                  • FBgn0030705
                  • FBgn0045942
                  • FBgn0045943
                  • FBgn0045944
                  Datasets (0)
                  Study focus (0)
                  Experimental Role
                  Project
                  Project Type
                  Title
                  References (988)