immunophilin - FK506-binding protein domain and a tetratricopeptide repeat - essential for the normal function of the germline stem cells - a conserved cochaperone that collaborates with Hsp90 during piRNA biogenesis, potentially at the loading step of RNAs into Piwi proteins
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.52
There is only one protein coding transcript and one polypeptide associated with this gene
Interacts with Hsp83.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\shu using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\shu in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: shu CG4735
shu is essential for the biogenesis of all piRNA populations in D. melanogaster.
shu is essential for the normal function of the germline stem cells in females and is also required at later stages of oogenesis.
The shu locus affects early oogenesis: mutations cause the production of few, defective germ cells.