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Gene Dmel\slo

General Information
Symbol	Dmel\slo	Species	D. melanogaster
Name	slowpoke	Annotation symbol	CG10693
Feature type	protein_coding_gene	FlyBase ID	FBgn0003429
Gene Model Status	Current	Stock availability	19 publicly available
Also Known As	dSlo, Slo1
Genomic Location
Chromosome (arm)	3R	Recombination map	3-86
Cytogenetic map	96A14-96A17	Sequence location	3R:20,488,213..20,537,317 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene slowpoke is referred to in FlyBase by the symbol Dmel\slo (CG10693, FBgn0003429). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; calcium-activated potassium channel activity. There is experimental evidence that it is involved in the biological process: male courtship behavior, veined wing generated song production; circadian rhythm; potassium ion transport; circadian behavior; response to drug. 45 alleles are reported. The phenotypes of these alleles are annotated with: neuron; neuromuscular junction; indirect flight muscle. It has 23 annotated transcripts and 23 annotated polypeptides. Protein features are: Calcium-activated potassium channel Slo; Ion transport 2; Ion transport domain; NAD(P)-binding domain; Potassium channel, calcium-activated, BK, alpha subunit; Voltage-dependent potassium channel. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages, during late pupal stages, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval midgut, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1637301_a_at completely aligns to an exonic region common to each of the 18 FlyBase-annotated transcript isoforms of slo. Gene sequence location is 3R:20488213..20537317.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	slo: slowpoke (J.C. Hall) Isolated in screen for third chromosomal temperature-sensitive paralytic mutants (Elkins et al., 1986); this one is uncoordinated and unable to climb when exposed to 38 but not completely paralyzed; four-minute exposure to that high temperature causes several minutes of motionlessness on return to 22. Legs shake when under ether anesthesia, as in Shaker mutants but less extreme. Unconditionally defective in behavior (e.g., diminished flight ability; tends to walk or fly in anomalous short hops when in large open container). Physiologically, the mutation abolishes Ca2+-dependent potassium current (IC), as shown, and analyzed further, in a variety of experiments involving recordings from dorsal longitudinal flight muscles (DLMs) of adults (Elkins et al., 1986; Elkins and Ganetzky, 1988): DLM spikes abnormally broadened after stimulation of giant fiber nerve pathway (one of whose endpoints is DLMs) or of motor neurons synapsing on these muscles. From voltage clamp analyses, a peak of early outward current following a step pulse from -80 to -40 mV, as revealed by a Sh mutation, is absent in slo, though inward Ca2+ currents in same traces are normal; no early outward current seen when slo is treated with 4-aminopyridine (which phenocopies Sh) or combined with Sh14. (This double mutant has very low viability and severe impairment in locomotor activity); charybdotoxin, which blocks IC channels in wildtype DLMs, had no effect on outward currents in slo; delayed excitation of DLMs, observed in response to depolarizing currents delivered to wild-type (or Sh), absent in slo, and spike amplitudes increased; these abnormalities phenocopied by reducing IC in normal muscle by injecting EGTA into such cells or using low-Ca2+ saline; the lengthened muscle action potentials in slo indicate importance of IC in effecting repolarization of such potentials.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03	Alleles slo[MI06325]
FB2013_02	Controlled Vocabulary Terms potassium ion transmembrane transport
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 96A14-96A17   Limits computationally determined from genome sequence between P{PZ}crb07207&P{PZ}BRWD305842 and P{EP}CycB3EP3127
Experimentally Determined Cytological Location
Cytogenetic map Notes References 96A17-96A17   (determined by in situ hybridisation)   (Atkinson, 1992) 96A17-96A17   (determined by in situ hybridisation)   (Atkinson et al., 1991)
Experimentally Determined Recombination Data
Location	3-86   3-90.0 (Atkinson et al., 1991)
Left of (cM)	tx (Atkinson et al., 1991)
Right of (cM)	hh (Atkinson et al., 1991)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\slo for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters. Gene model reviewed during 5.44 Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.47 Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated gene_with_stop_codon_read_through ; SO:0000697 Stop-codon suppression (UGA) postulated; FBrf0216884.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) slo-RA FBtr0084684  NM_079762   4896   1175 slo-RB FBtr0084683  NM_170164   4712   1183 slo-RC FBtr0084685  NM_206566   4712   1183 slo-RD FBtr0100622  NM_001014664   4896   1175 slo-RE FBtr0100623  NM_001014663   4896   1175 slo-RF FBtr0100624  NM_001014662   4896   1175 slo-RH FBtr0100627  NM_001014660   4896   1175 slo-RI FBtr0100629  NM_001014659   5010   1213 slo-RJ FBtr0100631  NM_001014658   4911   1180 slo-RK FBtr0100632  NM_001014657   4863   1164 slo-RL FBtr0100633  NM_001014656   4932   1187 slo-RM FBtr0100634  NM_001014655   4962   1197 slo-RN FBtr0100635  NM_001014654   4971   1200 slo-RO FBtr0100636  NM_001014653   4863   1164 slo-RP FBtr0100637  NM_001014652   4863   1164 slo-RQ FBtr0100638  NM_001014651   4896   1175 slo-RR FBtr0301581  NM_001014661   5120   1210 slo-RS FBtr0301582  NM_001170241   8854   1210 slo-RT FBtr0330286  NM_001275995   8130   1217 slo-RU FBtr0330287  NM_001275996   4896   1191 slo-RV FBtr0334294  NM_001275997   4568   1135 slo-RW FBtr0334295  NM_001275998   4640   1159 slo-RX FBtr0334296  NM_001275999   4619   1152
Additional Transcript Data & Comments
Reported size (kB)	11, 5.8 (northern blot) (Atkinson et al., 1991)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein slo-PA   FBpp0084064   130.3   1175   5.15     NP_524486   AAF56324 slo-PB   FBpp0084063   131.4   1183   5.37     NP_733029   AAN14013 slo-PC   FBpp0089227   131.4   1183   5.31     NP_996289   AAS65211 slo-PD   FBpp0100082   130.5   1175   5.20     NP_001014664   AAX52987 slo-PE   FBpp0100083   130.3   1175   5.20     NP_001014663   AAX52988 slo-PF   FBpp0100084   130.3   1175   5.11     NP_001014662   AAX52977 slo-PH   FBpp0100086   130.3   1175   5.10     NP_001014660   AAX52985 slo-PI   FBpp0100089   134.5   1213   5.51     NP_001014659   AAX52983 slo-PJ   FBpp0100091   130.8   1180   5.37     NP_001014658   AAX52984 slo-PK   FBpp0100092   129.0   1164   5.24     NP_001014657   AAX52981 slo-PL   FBpp0100093   131.6   1187   5.10     NP_001014656   AAX52982 slo-PM   FBpp0100094   132.8   1197   5.11     NP_001014655   AAX52979 slo-PN   FBpp0100095   133.1   1200   5.31     NP_001014654   AAX52978 slo-PO   FBpp0100096   129.0   1164   5.19     NP_001014653   AAX52986 slo-PP   FBpp0100097   129.0   1164   5.24     NP_001014652   AAX52990 slo-PQ   FBpp0100098   130.3   1175   5.15     NP_001014651   AAX52989 slo-PR   FBpp0290796   134.3   1210   5.68     NP_001014661   AAX52980 slo-PS   FBpp0290797   134.4   1210   5.68     NP_001163712   ACZ95006 slo-PT   FBpp0303318   135.2   1217   5.21     NP_001262924   AGB96304 slo-PU   FBpp0303319   132.0   1191   5.11     NP_001262925   AGB96305 slo-PV   FBpp0306409   125.9   1135   5.24     NP_001262926   AGB96306 slo-PW   FBpp0306410   128.5   1159   5.19     NP_001262927   AGB96307 slo-PX   FBpp0306411   127.7   1152   5.51     NP_001262928   AGB96308
Additional Polypeptide Data & Comments
Reported size (kDa)	1235, 1175, 1166 (aa) (Adelman et al., 1992) 1184 (aa) (Atkinson et al., 1991)
Comments	This is the A1/C2/E1/G3/I0 form of the slo protein. See sloA1C2E1G3I0 for a functional analysis of the protein. (Adelman et al., 1992) PCR analysis has demonstrated that many alternate coding sequences exist for the slo protein. Conserved amino acids 18-326 encode the first five and part of the sixth transmembrane domain and are followed by domains A-J. The variable A, C, E, G, and I domains have alternate forms and the B, D, F, H, and J domains are conserved. The A domains (A1-A3) are 30aa long, B is 37aa, C1 and C2 are 35aa, D is 104aa,E1 and E2 are 37aa, F is 79aa, G1-G6 are 60, 27, 13, 47, 22, and 59 aa long, respectively, H is 65aa, I0 and I1 are 0 and 22 aa, respectively,and J is 440aa. It is not known how many of the 144 potential forms of the protein are actually used in the fly head but evidence for at least 31 has been obtained. Results suggest that the different isoforms are functionally diverse. (Adelman et al., 1992) This is the A1/C2/E2/G5/I0 form of the slo protein. See sloA1C2E2G5I0 for a functional analysis of the protein. (Adelman et al., 1992) slo protein has seven hydrophobic domains near the amino terminus, a structure that is similar to other known K+-channel polypeptides. Similarities are observed between the slo protein and other voltage-gated channels in the S4 domain which is thought to mediate voltage sensitivity. The greatest similarity to other K+-channel polypeptides is in the H5 domain, an integral part of the ion conduction pore. Outside of these two regions, the slo protein is distinct from all known K+ channels. A putative EF-hand domain and an ATP-binding site were identified. The protein sequence is probably incomplete at the amino terminus. (Atkinson et al., 1991)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Voltage-dependent potassium channel (IPR003091) Potassium channel, calcium-activated, BK, alpha subunit (IPR003929) Ion transport domain (IPR005821) NAD(P)-binding domain (IPR016040) Ion transport 2 (IPR013099) Calcium-activated potassium channel Slo (IPR024939)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA441418   AA567346   AE014297 AAF56324   AE014297 AAN14013   AE014297 AAS65211   AE014297 AAX52977   AE014297 AAX52978   AE014297 AAX52979   AE014297 AAX52980   AE014297 AAX52981   AE014297 AAX52982   AE014297 AAX52983   AE014297 AAX52984   AE014297 AAX52985   AE014297 AAX52986   AE014297 AAX52987   AE014297 AAX52988   AE014297 AAX52989   AE014297 AAX52990   AE014297 ACZ95006   AE014297 AGB96304   AE014297 AGB96305   AE014297 AGB96306   AE014297 AGB96307   AE014297 AGB96308   AI114075   AI402739   AI404492   AI404927   AW940380   AW942413   AY060274 AAL25313   BG633192   BI609388   BI611550   BI617371   BT004876 AAO45232   BT088905   CK135048   CO179017   CO185300   CO190784   CO261885   CO262976   CO263514   CO263617   CO265039   CO265583   CO266946   CO273125   CO274918   CO276748   CO279961   CO281449   CO282452   CO285182   CO285843   CO287539   CO288046   CO288310   CO291150   CO291444   CO295309   CO295784   CO296143   CO299577   CO300683   CO301090   CO308858   CO311159   CO312025   CO313123   CO313566   CO317814   CO317896   CO321593   CO322053   CO322090   CO324869   CO326719   CO327040   CO327466   CO327982   CO330805   CO331283   CO332190   CO339588   CO340150   CO341044   CO341995   CO345026   CO345071   CZ467771   CZ467921   CZ488541   EC054241   EC054845   EC056076   EC057400   EC059116   EC059343   EC062467   EC065276   EC066292   EC066304   EC069548   EC070807   EC070935   EC073085   EC074845   EC075761   EC076544   EC080619   EC081424   EC083935   EC084237   EC085045   EC085894   EC087633   EC194389   EC196878   EC201220   EC201544   EC204996   EC207596   EC210626   EC213789   EC215526   EC218773   EC219529   EC220282   EC222927   EC225324   EC226249   EC228185   EC230603   EC231329   EC232190   EC232435   EC233355   EC234907   EC235413   EC240075   EC242001   EC242610   EC242838   EC245567   EC246258   EC246656   EC247624   EC248841   EC249993   EC250521   EC255385   EC255641   EC255683   EC255806   EC255998   EC256750   EC256856   EC259585   EC260387   EL874953   EL874954   M69053 AAA28902   M96840 AAA28651   U40221   U40314   U40315 AAC47020   U40315 AAC47021
UniProtKB/Swiss-Prot	Q03720
UniProtKB/TrEMBL	E1JIV7 Q95T95
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References regulatory region FBsf0000435559 3R:20,493,023..20,495,471 evidence=Reporter construct (in vivo) (Brenner et al., 1996, Halfon, 2012.6.19) regulatory region FBsf0000435811 3R:20,489,599..20,495,471 evidence=Reporter construct (in vivo) (Brenner et al., 1996, Halfon, 2012.6.19) regulatory region FBsf0000436722 3R:20,487,496..20,495,471 evidence=Reporter construct (in vivo) (Brenner et al., 1996, Halfon, 2012.6.19)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference adult stage   adult head   (Atkinson et al., 1991)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference wandering third instar larval stage   embryonic/larval neuromuscular junction   • neuromuscular junction (Zhou et al., 1999) adult stage   adult brain | restricted   • neuron projection (Jepson et al., 2012) adult pedunculus   • neuron projection (Jepson et al., 2012) mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
	slo protein is detected in the neuronal tracts in the adult brain including the mushroom body peduncle, but not in the mushroom body lobes, calyx or ellipsoid body. There is strong colocalisation with dysc. (Jepson et al., 2012)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
membrane inferred from direct assay (Moss et al., 1996) neuron projection inferred from direct assay (de la Paz Fernandez et al., 2007) neuronal cell body inferred from direct assay (de la Paz Fernandez et al., 2007)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval midgut, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    10.775 Larval Midgut    190.2 Larval Hindgut    10.3 Larval Malpighian Tubules    2.7 Larval Fat Body    7.1 Larval Salivary Gland    4.1 Larval Trachea    8.45 Larval Carcass    61.6 Adult Head    98.4 Adult Eye    73.675 Adult Brain    97.7 Adult Thoracic-Abdominal Ganglion    53.1 Adult Crop    41.7 Adult Midgut    64 Adult Hindgut    15 Adult Malpighian Tubules    5.3 Adult Fat Body    22.5 Adult Salivary Gland    10.2 Adult Heart    32.15 Adult VirginFemale Spermatheca    23.5 Adult InseminatedFemale Spermatheca    24.4 Adult Ovary    2 Adult Testis    11.5 Adult Male Accessory Gland    7.4 Adult Carcass    121 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    10.775 Larval Midgut    190.2 Larval Hindgut    10.3 Larval Malpighian Tubules    2.7 Larval Fat Body    7.1 Larval Salivary Gland    4.1 Larval Trachea    8.45 Larval Carcass    61.6 Adult Head    98.4 Adult Eye    73.675 Adult Brain    97.7 Adult Thoracic-Abdominal Ganglion    53.1 Adult Crop    41.7 Adult Midgut    64 Adult Hindgut    15 Adult Malpighian Tubules    5.3 Adult Fat Body    22.5 Adult Salivary Gland    10.2 Adult Heart    32.15 Adult VirginFemale Spermatheca    23.5 Adult InseminatedFemale Spermatheca    24.4 Adult Ovary    2 Adult Testis    11.5 Adult Male Accessory Gland    7.4 Adult Carcass    121 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    10.775 Larval Midgut    190.2 Larval Hindgut    10.3 Larval Malpighian Tubules    2.7 Larval Fat Body    7.1 Larval Salivary Gland    4.1 Larval Trachea    8.45 Larval Carcass    61.6 Adult Head    98.4 Adult Eye    73.675 Adult Brain    97.7 Adult Thoracic-Abdominal Ganglion    53.1 Adult Crop    41.7 Adult Midgut    64 Adult Hindgut    15 Adult Malpighian Tubules    5.3 Adult Fat Body    22.5 Adult Salivary Gland    10.2 Adult Heart    32.15 Adult VirginFemale Spermatheca    23.5 Adult InseminatedFemale Spermatheca    24.4 Adult Ovary    2 Adult Testis    11.5 Adult Male Accessory Gland    7.4 Adult Carcass    121 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    10.775 Larval Midgut    190.2 Larval Hindgut    10.3 Larval Malpighian Tubules    2.7 Larval Fat Body    7.1 Larval Salivary Gland    4.1 Larval Trachea    8.45 Larval Carcass    61.6 Adult Head    98.4 Adult Eye    73.675 Adult Brain    97.7 Adult Thoracic-Abdominal Ganglion    53.1 Adult Crop    41.7 Adult Midgut    64 Adult Hindgut    15 Adult Malpighian Tubules    5.3 Adult Fat Body    22.5 Adult Salivary Gland    10.2 Adult Heart    32.15 Adult VirginFemale Spermatheca    23.5 Adult InseminatedFemale Spermatheca    24.4 Adult Ovary    2 Adult Testis    11.5 Adult Male Accessory Gland    7.4 Adult Carcass    121 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    10.775 Larval Midgut    190.2 Larval Hindgut    10.3 Larval Malpighian Tubules    2.7 Larval Fat Body    7.1 Larval Salivary Gland    4.1 Larval Trachea    8.45 Larval Carcass    61.6 Adult Head    98.4 Adult Eye    73.675 Adult Brain    97.7 Adult Thoracic-Abdominal Ganglion    53.1 Adult Crop    41.7 Adult Midgut    64 Adult Hindgut    15 Adult Malpighian Tubules    5.3 Adult Fat Body    22.5 Adult Salivary Gland    10.2 Adult Heart    32.15 Adult VirginFemale Spermatheca    23.5 Adult InseminatedFemale Spermatheca    24.4 Adult Ovary    2 Adult Testis    11.5 Adult Male Accessory Gland    7.4 Adult Carcass    121 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    10.775 Larval Midgut    190.2 Larval Hindgut    10.3 Larval Malpighian Tubules    2.7 Larval Fat Body    7.1 Larval Salivary Gland    4.1 Larval Trachea    8.45 Larval Carcass    61.6 Adult Head    98.4 Adult Eye    73.675 Adult Brain    97.7 Adult Thoracic-Abdominal Ganglion    53.1 Adult Crop    41.7 Adult Midgut    64 Adult Hindgut    15 Adult Malpighian Tubules    5.3 Adult Fat Body    22.5 Adult Salivary Gland    10.2 Adult Heart    32.15 Adult VirginFemale Spermatheca    23.5 Adult InseminatedFemale Spermatheca    24.4 Adult Ovary    2 Adult Testis    11.5 Adult Male Accessory Gland    7.4 Adult Carcass    121 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    10.775 Larval Midgut    190.2 Larval Hindgut    10.3 Larval Malpighian Tubules    2.7 Larval Fat Body    7.1 Larval Salivary Gland    4.1 Larval Trachea    8.45 Larval Carcass    61.6 Adult Head    98.4 Adult Eye    73.675 Adult Brain    97.7 Adult Thoracic-Abdominal Ganglion    53.1 Adult Crop    41.7 Adult Midgut    64 Adult Hindgut    15 Adult Malpighian Tubules    5.3 Adult Fat Body    22.5 Adult Salivary Gland    10.2 Adult Heart    32.15 Adult VirginFemale Spermatheca    23.5 Adult InseminatedFemale Spermatheca    24.4 Adult Ovary    2 Adult Testis    11.5 Adult Male Accessory Gland    7.4 Adult Carcass    121 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    10.775 Larval Midgut    190.2 Larval Hindgut    10.3 Larval Malpighian Tubules    2.7 Larval Fat Body    7.1 Larval Salivary Gland    4.1 Larval Trachea    8.45 Larval Carcass    61.6 Adult Head    98.4 Adult Eye    73.675 Adult Brain    97.7 Adult Thoracic-Abdominal Ganglion    53.1 Adult Crop    41.7 Adult Midgut    64 Adult Hindgut    15 Adult Malpighian Tubules    5.3 Adult Fat Body    22.5 Adult Salivary Gland    10.2 Adult Heart    32.15 Adult VirginFemale Spermatheca    23.5 Adult InseminatedFemale Spermatheca    24.4 Adult Ovary    2 Adult Testis    11.5 Adult Male Accessory Gland    7.4 Adult Carcass    121 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    98.4   NA  Eye    73.675   NA  Brain    97.7   no informative data  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    53.1   NA  Crop    41.7   190.2  Midgut    64   no informative data  Hindgut    no informative data   2.7  Malpighian Tubules    5.3   7.1  Fat Body    no informative data   4.1  Salivary Gland    no informative data   NA  Heart    32.15   8.45  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    2   NA  Testis    no informative data   NA  Male Accessory Gland    7.4   61.6  Carcass    121 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    2 central nervous system, pupae P8    115 head, virgin 1-day female    28 head, virgin 4-day female    30 head, virgin 20-day female    15 head, mated 1-day female    27 head, mated 4-day female    25 head, mated 20-day female    14 head, mated 1-day male    39 head, mated 4-day male    44 head, mated 20-day male    34 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    4 digestive system, 4-day adult    3 digestive system, 20-day adult    2 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    11 carcass, larvae L3 wandering    4 carcass, 1-day adult    9 carcass, 4-day adult    7 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    2 central nervous system, pupae P8  (115) head, virgin 1-day female  (28) head, virgin 4-day female  (30) head, virgin 20-day female    15 head, mated 1-day female  (27) head, mated 4-day female    25 head, mated 20-day female    14 head, mated 1-day male  (39) head, mated 4-day male  (44) head, mated 20-day male  (34) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    4 digestive system, 4-day adult    3 digestive system, 20-day adult    2 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    11 carcass, larvae L3 wandering    4 carcass, 1-day adult    9 carcass, 4-day adult    7 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    2 central nervous system, pupae P8  (115) head, virgin 1-day female    28 head, virgin 4-day female    30 head, virgin 20-day female    15 head, mated 1-day female    27 head, mated 4-day female    25 head, mated 20-day female    14 head, mated 1-day male    39 head, mated 4-day male    44 head, mated 20-day male    34 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    4 digestive system, 4-day adult    3 digestive system, 20-day adult    2 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    11 carcass, larvae L3 wandering    4 carcass, 1-day adult    9 carcass, 4-day adult    7 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    2 central nervous system, pupae P8    115 head, virgin 1-day female    28 head, virgin 4-day female    30 head, virgin 20-day female    15 head, mated 1-day female    27 head, mated 4-day female    25 head, mated 20-day female    14 head, mated 1-day male    39 head, mated 4-day male    44 head, mated 20-day male    34 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    4 digestive system, 4-day adult    3 digestive system, 20-day adult    2 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    11 carcass, larvae L3 wandering    4 carcass, 1-day adult    9 carcass, 4-day adult    7 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    2 central nervous system, pupae P8    115 head, virgin 1-day female    28 head, virgin 4-day female    30 head, virgin 20-day female    15 head, mated 1-day female    27 head, mated 4-day female    25 head, mated 20-day female    14 head, mated 1-day male    39 head, mated 4-day male    44 head, mated 20-day male    34 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    4 digestive system, 4-day adult    3 digestive system, 20-day adult    2 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    11 carcass, larvae L3 wandering    4 carcass, 1-day adult    9 carcass, 4-day adult    7 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    2 central nervous system, pupae P8  (115) head, virgin 1-day female  28 head, virgin 4-day female  30 head, virgin 20-day female    15 head, mated 1-day female  27 head, mated 4-day female    25 head, mated 20-day female    14 head, mated 1-day male  (39) head, mated 4-day male  (44) head, mated 20-day male  (34) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    4 digestive system, 4-day adult    3 digestive system, 20-day adult    2 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    11 carcass, larvae L3 wandering    4 carcass, 1-day adult    9 carcass, 4-day adult    7 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    2 central nervous system, pupae P8  115 head, virgin 1-day female    28 head, virgin 4-day female    30 head, virgin 20-day female    15 head, mated 1-day female    27 head, mated 4-day female    25 head, mated 20-day female    14 head, mated 1-day male    39 head, mated 4-day male    44 head, mated 20-day male    34 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    4 digestive system, 4-day adult    3 digestive system, 20-day adult    2 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    11 carcass, larvae L3 wandering    4 carcass, 1-day adult    9 carcass, 4-day adult    7 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    2 central nervous system, pupae P8    115 head, virgin 1-day female    28 head, virgin 4-day female    30 head, virgin 20-day female    15 head, mated 1-day female    27 head, mated 4-day female    25 head, mated 20-day female    14 head, mated 1-day male    39 head, mated 4-day male    44 head, mated 20-day male    34 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    4 digestive system, 4-day adult    3 digestive system, 20-day adult    2 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    11 carcass, larvae L3 wandering    4 carcass, 1-day adult    9 carcass, 4-day adult    7 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages, during late pupal stages, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    6 embryo 16-18hr    12 embryo 18-20hr    14 embryo 20-22hr    13 embryo 22-24hr    17 larva L1    13 larva L2    6 larva L3 12hr old    3 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    4 white prepupae new    2 white prepupae 12hr    2 white prepupae 24hr    6 pupae 2d postWPP    32 pupae 3d postWPP    30 pupae 4d postWPP    13 adult male 01day    14 adult male 05day    12 adult male 30day    11 adult female 01day    7 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    6 embryo 16-18hr    12 embryo 18-20hr    14 embryo 20-22hr    13 embryo 22-24hr    17 larva L1    13 larva L2    6 larva L3 12hr old    3 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    4 white prepupae new    2 white prepupae 12hr    2 white prepupae 24hr    6 pupae 2d postWPP  (32) pupae 3d postWPP  (30) pupae 4d postWPP    13 adult male 01day    14 adult male 05day    12 adult male 30day    11 adult female 01day    7 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    6 embryo 16-18hr    12 embryo 18-20hr    14 embryo 20-22hr    13 embryo 22-24hr    17 larva L1    13 larva L2    6 larva L3 12hr old    3 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    4 white prepupae new    2 white prepupae 12hr    2 white prepupae 24hr    6 pupae 2d postWPP    32 pupae 3d postWPP    30 pupae 4d postWPP    13 adult male 01day    14 adult male 05day    12 adult male 30day    11 adult female 01day    7 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    6 embryo 16-18hr    12 embryo 18-20hr    14 embryo 20-22hr    13 embryo 22-24hr    17 larva L1    13 larva L2    6 larva L3 12hr old    3 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    4 white prepupae new    2 white prepupae 12hr    2 white prepupae 24hr    6 pupae 2d postWPP    32 pupae 3d postWPP    30 pupae 4d postWPP    13 adult male 01day    14 adult male 05day    12 adult male 30day    11 adult female 01day    7 adult female 05day    2 adult female 30day    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    6 embryo 16-18hr    12 embryo 18-20hr    14 embryo 20-22hr    13 embryo 22-24hr    17 larva L1    13 larva L2    6 larva L3 12hr old    3 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    4 white prepupae new    2 white prepupae 12hr    2 white prepupae 24hr    6 pupae 2d postWPP    32 pupae 3d postWPP    30 pupae 4d postWPP    13 adult male 01day    14 adult male 05day    12 adult male 30day    11 adult female 01day    7 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    6 embryo 16-18hr    12 embryo 18-20hr    14 embryo 20-22hr    13 embryo 22-24hr    17 larva L1    13 larva L2    6 larva L3 12hr old    3 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    4 white prepupae new    2 white prepupae 12hr    2 white prepupae 24hr    6 pupae 2d postWPP  32 pupae 3d postWPP  30 pupae 4d postWPP    13 adult male 01day    14 adult male 05day    12 adult male 30day    11 adult female 01day    7 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    6 embryo 16-18hr    12 embryo 18-20hr    14 embryo 20-22hr    13 embryo 22-24hr    17 larva L1    13 larva L2    6 larva L3 12hr old    3 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    4 white prepupae new    2 white prepupae 12hr    2 white prepupae 24hr    6 pupae 2d postWPP    32 pupae 3d postWPP    30 pupae 4d postWPP    13 adult male 01day    14 adult male 05day    12 adult male 30day    11 adult female 01day    7 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    6 embryo 16-18hr    12 embryo 18-20hr    14 embryo 20-22hr    13 embryo 22-24hr    17 larva L1    13 larva L2    6 larva L3 12hr old    3 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    4 white prepupae new    2 white prepupae 12hr    2 white prepupae 24hr    6 pupae 2d postWPP    32 pupae 3d postWPP    30 pupae 4d postWPP    13 adult male 01day    14 adult male 05day    12 adult male 30day    11 adult female 01day    7 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    5 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    6 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    5 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    6 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    5 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    6 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    5 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    6 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    5 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    6 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    5 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    6 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    5 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    6 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    5 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    6 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_14 mE1_20_mRNA_expression_cluster_14
External Data & Images
Linkouts	BDGP expression data • LD16342 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003429 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10693-RB
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Dcr-2Scer\UAS.cDa, Scer\GAL4e22c, Scer\GAL4sqh.PW sloKK108671 viable slo4 sloe03162 slof05915 viable, with Dcr-2Scer\UAS.cDa, Scer\GAL4e22c, Scer\GAL4sqh.PW sloGD244 viable, with Scer\GAL4pnr-MD237 sloGD244 Sterility Allele fertile sloe03162 slof05915 Other Phenotypes Allele behavior defective slo1 slo4 slo18 chemical resistant slohs.B52H chemical sensitive slo4 chemical sensitive (with slo4) slo18 chemical sensitive (with slo18) slo4 chemical sensitive | recessive slo1 slo4 circadian rhythm defective slo1 slo4 circadian rhythm defective (with slo1) slo4 circadian rhythm defective (with slo4) slo1 courtship behavior defective | male slo1 flight defective | recessive slo1 slo4 neuroanatomy defective slo1 slo98 neuroanatomy defective | heat sensitive slo1 neurophysiology defective slo1 slo4 slo98 slounspecified Phenotype manifest in Allele indirect flight muscle slo4 muscle fiber | larval stage slo1 neuromuscular junction slo1 slo98 neuromuscular junction | heat sensitive slo1 neuron slo4 NMJ bouton | supernumerary slo1 slo4 slo98 NMJ bouton | supernumerary | heat sensitive slo1
Classical Alleles ( 19 )
For All Classical Alleles Show
Allele of slo Class Mutagen Stocks Known lesion slo1 ethyl methanesulfonate 2 -- sloe03162 piggyBac transposase 2 -- slof05915 piggyBac transposase 2 -- sloc02408 piggyBac transposase 1 -- sloc02411 1 -- sloMB04469 1 -- sloMB11481 1 -- sloMI01126 1 -- sloMI02233 1 -- sloMI04413 1 -- sloMI06325 1 -- slo4 amorphic allele - genetic evidence, loss of function allele gamma ray 0 -- slo18 0 Yes slo98 0 -- sloA117 X ray 0 -- sloc02203 piggyBac transposase 0 -- sloC337-1164.S942A.T:Sjap\GST 0 Yes slots1 0 -- slounspecified 0 --
Alleles Carried on Transgenic Constructs ( 27 )
For All Alleles Carried on Transgenic Constructs Show
Allele of slo Class Mutagen Stocks Known lesion sloGD244 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes sloJF01246 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes sloJF01470 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes sloJF02146 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes sloKK108671 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes slo20:EX.T:Ecol\lacZ in vitro construct - regulatory fusion 0 Yes slo4E:EX.T:Ecol\lacZ in vitro construct - regulatory fusion 0 Yes slo55:EX.T:Ecol\lacZ in vitro construct - regulatory fusion 0 Yes sloB2.1.T:Scer\GAL4 in vitro construct - deletion 0 Yes sloBII.T:Scer\GAL4 in vitro construct - coding region fusion 0 Yes sloBR17.T:Ecol\lacZ in vitro construct - deletion 0 Yes sloEX.T:Ecol\lacZ in vitro construct - deletion 0 Yes slohs.B52H in vitro construct - regulatory fusion 0 Yes sloNIG.10693R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes sloP1.T:Ecol\lacZ in vitro construct - coding region fusion 0 Yes sloP10a.hs.T:Ecol\lacZ in vitro construct - deletion 0 Yes sloP10b.hs.T:Ecol\lacZ in vitro construct - deletion 0 Yes sloP12.T:Ecol\lacZ in vitro construct - deletion 0 Yes sloP13.T:Ecol\lacZ in vitro construct - deletion 0 Yes sloP2.T:Ecol\lacZ in vitro construct - deletion 0 Yes sloP3.T:Ecol\lacZ in vitro construct - deletion 0 Yes sloP4.T:Ecol\lacZ in vitro construct - deletion 0 Yes sloP5.T:Ecol\lacZ in vitro construct - deletion 0 Yes sloP6.T:Ecol\lacZ in vitro construct - deletion 0 Yes sloP7.T:Ecol\lacZ in vitro construct - deletion 0 Yes sloP8.T:Ecol\lacZ in vitro construct - deletion 0 Yes sloP9.T:Ecol\lacZ in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)crb87-5 (Atkinson et al., 1991, Adamson and Shearn, 1996) Df(3R)slo8 (Atkinson et al., 1991, Cobb, 1996) Df(3R)tld-γ1 (Adamson and Shearn, 1996) In(3R)slo4 (Atkinson et al., 1991, Leibovitch et al., 1995) In(3R)Ubx7LLatsR (Cobb, 1996) T(Y;3)A117 (Atkinson et al., 1991, Adamson and Shearn, 1996) Tp(3;2)slo3 (Atkinson et al., 1991)
Not disrupted in	Df(3R)crb87-4 (Atkinson et al., 1991, Cobb, 1996) Df(3R)crb87-5 (Cobb, 1996) Df(3R)XTA1 (Cobb, 1996) T(Y;3)A117 (Cobb, 1996)
Partially disrupted in	Df(3R)ash18 (Adamson and Shearn, 1996)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD244} NA P{KK108671} NA P{NIG.10693R} NA P{TRiP.JF01246} NA P{TRiP.JF01470} NA P{TRiP.JF02146} NA reporter construct P{slo.4E/EX} No P{slo.20/EX} No P{slo.55/EX} No P{slo.BR17} No P{slo.EX} No P{slo.P1} No P{slo.P2} No P{slo.P3} No P{slo.P4} No P{slo.P5} No P{slo.P6} No P{slo.P7} No P{slo.P8} No P{slo.P9} No P{slo.P10a} No P{slo.P10b} No P{slo.P12} No P{slo.P13} No GAL4 construct P{slo.Gal4B2.1} No P{slo.Gal4BII} No heat-shock construct P{hs-slo.B52H} NA P{slo.P10a} NA P{slo.P10b} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}sloMI01126 NA Mi{MIC}sloMI02233 NA Mi{MIC}sloMI04413 NA Mi{MIC}sloMI06325 NA PBac{PB}sloc02203 NA PBac{PB}sloc02408 NA PBac{PB}sloc02411 NA PBac{RB}sloe03162 NA PBac{WH}slof05915 NA insertion of enhancer trap binary system Mi{ET1}sloMB04469 No Mi{ET1}sloMB11481 No
Gene Ontology: Function, Process & Cellular Component ( 15 unique terms )
Terms Based on Experimental Evidence ( 10 terms )
Molecular Function
CV term Evidence References
calcium-activated potassium channel activity inferred from direct assay (Moss et al., 1996) inferred from direct assay (assigned by UniProtKB) (Schopperle et al., 1998, Xia et al., 1998, Wang et al., 1999) protein binding inferred from physical interaction with Pka-C1 (assigned by UniProtKB) (Wang et al., 1999) inferred from physical interaction with Slip1 (assigned by UniProtKB) (Xia et al., 1998) inferred from physical interaction with Slob (assigned by UniProtKB) (Schopperle et al., 1998)
Biological Process
CV term Evidence References
circadian behavior inferred from mutant phenotype (de la Paz Fernandez et al., 2007) circadian rhythm inferred from mutant phenotype (Ceriani et al., 2002) male courtship behavior, veined wing generated song production inferred from mutant phenotype (Peixoto and Hall, 1998) potassium ion transport inferred from direct assay (Moss et al., 1996) inferred from direct assay (assigned by UniProtKB) (Schopperle et al., 1998, Xia et al., 1998, Wang et al., 1999) response to drug inferred from mutant phenotype (Ghezzi et al., 2004)
Cellular Component
CV term Evidence References
membrane inferred from direct assay (Moss et al., 1996) neuronal cell body inferred from direct assay (de la Paz Fernandez et al., 2007) neuron projection inferred from direct assay (de la Paz Fernandez et al., 2007)
Terms Based on Predictions or Assertions ( 8 terms )
Molecular Function
CV term Evidence References
calcium-activated potassium channel activity non-traceable author statement (Littleton and Ganetzky, 2000) large conductance calcium-activated potassium channel activity inferred from biological aspect of ancestor with PANTHER:PTN000002875 (assigned by RefGenome) (Gaudet et al., 2010) voltage-gated potassium channel activity inferred from biological aspect of ancestor with PANTHER:PTN000002873 (assigned by RefGenome) (Gaudet et al., 2010)
Biological Process
CV term Evidence References
male courtship behavior, veined wing generated song production non-traceable author statement (Greenspan and Ferveur, 2000, Sokolowski, 2001) potassium ion transmembrane transport inferred from biological aspect of ancestor with PANTHER:PTN000002871 (assigned by RefGenome) (Gaudet et al., 2010) potassium ion transport non-traceable author statement (Littleton and Ganetzky, 2000)
Cellular Component
CV term Evidence References
plasma membrane non-traceable author statement (Littleton and Ganetzky, 2000) voltage-gated potassium channel complex inferred from biological aspect of ancestor with PANTHER:PTN000002873 (assigned by RefGenome) (Gaudet et al., 2010)
Sequence Ontology: Class of Gene
	gene_with_edited_transcript (Graveley et al., 2011) gene_with_stop_codon_read_through (Jungreis et al., 2011) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
slo - dysc anti tag coimmunoprecipitation, western blot (Jepson et al., 2012)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions slo allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 67865 DroID - A comprehensive database of gene and protein interactions. • FBgn0003429 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42940
Orthologs
OrthoDB Orthologs (52) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6Q85GS Dipteran inclusive ortholog search EOG6QRHC0 Insect inclusive ortholog search EOG6GHXJD Arthropod inclusive ortholog search EOG6KWH81 Metazoa inclusive ortholog search EOG67Q8ZM
Orthologs in Drosophila Species (EOG6Q85GS)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\slo     Drosophila simulans   Dsim\GD21120 Y   Drosophila sechellia   Dsec\GM26618 Y   Drosophila erecta   Dere\GG11309 Y   Drosophila yakuba   Dyak\GE23506 Y   Drosophila ananassae   Dana\GF17221 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA10500 Y   Drosophila persimilis   Dper\GL13618 Y   Drosophila willistoni   Dwil\GK10969 Y   Drosophila virilis   Dvir\GJ23648 Y   Drosophila mojavensis   Dmoj\slo Y   Drosophila grimshawi   Dgri\GH18441 Y
Orthologs in non-Drosophila Dipterans (EOG6QRHC0)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL003765   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL003759   Anopheles gambiae Malaria mosquito  Agam\AGAP003709   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ005769
Orthologs in non-Dipteran Insects (EOG6GHXJD)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB47138   Apis mellifera Western honey bee  Amel\GB47139   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG007782   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH27249   Atta cephalotes Leafcutter ant  Acep\ACEP22555   Atta cephalotes Leafcutter ant  Acep\ACEP16363   Camponotus floridanus Florida carpenter ant  Cflo\CFLO23258   Camponotus floridanus Florida carpenter ant  Cflo\CFLO23262   Camponotus floridanus Florida carpenter ant  Cflo\CFLO23260   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19057   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19056   Linepithema humile Argentine ant  Lhum\LH11374   Linepithema humile Argentine ant  Lhum\LH11373   Linepithema humile Argentine ant  Lhum\LH11375   Pogonomyrmex barbatus Red harvester ant  Pbar\PB16138   Pogonomyrmex barbatus Red harvester ant  Pbar\PB20978   Solenopsis invicta Red fire ant  Sinv\SINV23240   Acyrthosiphon pisum Pea aphid  Apim\ACYPI010131   Bombyx mori Silkmoth  Bmor\BGIBMGA002400   Pediculus humanus Human body louse  Phum\PHUM221720   Tribolium castaneum Red flour beetle  Tcas\TC011288
Orthologs in non-Insect Arthropods (EOG6KWH81)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Mogs   Ixodes scapularis Deer tick  Isca\ISCW007718
Orthologs in non-Arthropod Metazoa (EOG67Q8ZM)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\slo-1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_028068gn   Danio rerio Zebrafish  Drer\kcnma1b   Danio rerio Zebrafish  Drer\kcnma1a   Xenopus tropicalis Western clawed frog  Xtro\kcnma1   Gallus gallus Domestic chicken  Ggal\KCNU1   Gallus gallus Domestic chicken  Ggal\KCNMA1   Mus musculus House mouse  Mmus\Kcnu1   Mus musculus House mouse  Mmus\Kcnma1   Rattus norvegicus Norway rat  Rnor\Kcnma1   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000014741   Homo sapiens Human  Hsap\ENSG00000156113   Homo sapiens Human  Hsap\KCNU1
Human Orthologs (2)
Gene OMIM HGNC Hsap\ENSG00000156113     Hsap\KCNU1
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD21120 Drosophila sechellia Dsec\GM26618 Drosophila erecta Dere\GG11309 Drosophila yakuba Dyak\GE23506 Drosophila ananassae Dana\GF17221 Drosophila pseudoobscura pseudoobscura Dpse\GA10500 Drosophila persimilis Dper\GL13618 Drosophila willistoni Dwil\GK10969 Drosophila virilis Dvir\GJ23648 Drosophila mojavensis Dmoj\slo Drosophila grimshawi Dgri\GH18441
Stocks & Reagents
Stocks Listed in FlyBase ( 19 )
Bloomington	4587 st1 slo1 18123 w1118; PBac{RB}sloe03162 18916 w1118; PBac{WH}slof05915 24811 w1118; Mi{ET1}sloMB04469 29918 w1118; Mi{ET1}sloMB11481
Harvard	- PBac{PB}sloc02408 - PBac{PB}sloc02411 - PBac{RB}sloe03162 - PBac{WH}slof05915
Kyoto	107809 st1 slo1
VDRC	v104421 P{KK108671}VIE-260B v6723 w1118; P{GD244}v6723
	More stocks available...
Genomic Clones ( 2 )
	BACR35N03 BACR47D16 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 128 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH10751 LD16342
Other clones	IP14811
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH24233 GH24788 HL01007 RH14161 RH47679
Other clones	745 10262 31404 31606 32645 36799 39013 45186 47560 54102 54595 60089 61161 61199 64988 66895 69968 73122 77978 80496 81534 101024 102694 104373 105859 107551 119697 145233 156397 156544 164619 165040 193169 214311.61 214339.12 214373.10 214381.7 214407.13 214471.57 214481.8 214533.9 214565.6 275308 CK01.3C.G4 CK01.24A.A2 CK01.44B.C10 CK01.61D.H7 CK01.78B.D3 CK01.82D.A2 CK01.85B.C11 CK01.86B.D4 CK01.86C.D11 CK01.98D.D1 CK01.103C.F6 CK01.106B.E1 CK01.106C.H6 CK01.106C.H8 CK01.109C.E11 CK01.112A.H2 CK01.142C.H11 EC054241 EC054845 EC056076 EC250521 EK007758 EK049632 EK058204 EK060914 EK066133 EK067610 EK068216 EK076313 EK079355 EK081163 EK086955 EK088717 EK089064 EK109652 EK115930 EK121955 EK141332 EK143126 EK148013 EK152059 EK157209 EK160522 EK168444 EK175842 EK179059 EK180043 EK186003 EK187118 EK187162 EK195036 EK209401 EK211562 EK212829 EK223629 EK227720 EK231451 EK233440 EK259527 EK269137 EK269642 EK296220 EK299011 EK302728 EP02324 EP04513 EP05537 EP07205 EP08356 EP10115 EP11759 EP13611 EP21144 EP21242 GH22026 IP15011 RH17881
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0003429 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42940
Antibody Information
	polyclonal (Jepson et al., 2012)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: slo CG10693 (Littleton, 1999.11)
Source for database merge of	Source for merge of: slo BcDNA:GH10751 (FlyBase, 1996-)
Additional comments	Source for merge of slo BcDNA:GH10751 was a shared cDNA (date:030728). (FlyBase, 1996-)
Other Comments
	ChEST reveals this is a target of Mef2. (Junion et al., 2005) The flight defect of slo null mutants arises from a lack of slo expression in muscle, whereas the "sticky-feet" phenotype arises from a lack of slo expression in nervous tissue. (Atkinson et al., 2000) 14-3-3ζ can interact with and modulate slo via Slob. (Zhou et al., 1999) Slob is identified as a protein that binds to the carboxy-terminal domain of slo in a yeast two-hybrid screen. Slob and slo co-immunoprecipitate from heads and heterologous host cells, suggesting they interact in vivo. (Schopperle et al., 1998) slo promoters are physically mapped and sequences responsible for the expression in the CNS, muscles and tracheal and midgut cells are functionally mapped. (Brenner et al., 1996) The region downstream of promoter C2 (exon C2 and exon C3) contains elements required for CNS expression, modulates expression in a developmental stage-specific manner and directs expression to the eye. (Brenner and Atkinson, 1996) Cloned slo channels in excised patches from Xenopus oocytes can exhibit large variability in gating properties, both within a single channel and among channels. (Silberberg et al., 1996) Mutation of slo causes a reduction of transmitter release at the neuromuscular junction. The slo mutation partially suppresses the increase in transmitter release caused by Sh mutants. The mutations confers suppression by reducing calcium influx into the nerve terminal. (Warbington et al., 1996) Developmental and tissue-specific expression of slo. (Becker et al., 1995) Protein phosphorylation modulates the activity of slo channels expressed in Xenopus oocytes. Mutant channel protein can block the modulation by ATP-γS demonstrating that phosphorylation of the slo channel protein itself modulates channel activity. (Esguerra et al., 1994) Alternate splicing of a common slo RNA precursor contributes to the functional diversity of the encoded large conductance calcium-activated potassium channel. The variable region of the slo channel subunit comprises modular, yet interactive functional domains which influence the essential features of unit conductance, calcium sensitivity and gating of the channel. (Lagrutta et al., 1994) Using PCR with nested primers and cloning from cDNA libraries, alternatively spliced versions predicting up to 144 different coding combinations were found. The existence of 31 of these was directly demonstrated. Excised inside out patch recordings show opening of the channel only when the Ca2+ is on the cytoplasmic side: opening increases both with depolarization and with increasing Ca2+ concentration. Single channel conductance is 126pS. Mean open times are different for different splice variants, proving that slo encodes a large family of functionally diverse Ca2+-activated K+ channels. (Adelman et al., 1992) Effects of potassium channel blocking drugs on the presynaptic action potential repolarization after electrotonic stimulation was studied. At least four K+ currents contribute to repolarization of the nerve terminal. (Gho and Ganetzky, 1992) Mutation analysis reveals that the slo polypeptide is essential for the expression or function of the channel mediating the fast Ca2+ activated K+ current. (Atkinson et al., 1991) Isolated in screen for third chromosomal temperature-sensitive paralytic mutants (Elkins, Ganetzky and Wu, 1986); this one is uncoordinated and unable to climb when exposed to 38oC but not completely paralyzed; four-minute exposure to that high temperature causes several minutes of motionlessness on return to 22oC. Legs shake when under ether anesthesia, as in Shaker mutants but less extreme. Unconditionally defective in behavior (e.g., diminished flight ability; tends to walk or fly in anomalous short hops when in large open container). Physiologically, the mutation abolishes Ca2+-dependent potassium current (IC), as shown, and analyzed further, in a variety of experiments involving recordings from dorsal longitudinal flight muscles (DLMs) of adults (Elkins, Ganetzky and Wu, 1986; Elkins and Ganetzky, 1988): DLM spikes abnormally broadened after stimulation of giant fiber nerve pathway (one of whose endpoints is DLMs) or of motor neurons synapsing on these muscles. From voltage clamp analyses, a peak of early outward current following a step pulse from -80 to -40 mV, as revealed by a Sh mutation, is absent in slo, though inward Ca2+ currents in same traces are normal; no early outward current seen when slo is treated with 4-aminopyridine (which phenocopies Sh) or combined with Sh14. (This double mutant has very low viability and severe impairment in locomotor activity); charybdotoxin, which blocks IC channels in wild-type DLMs, had no effect on outward currents in slo; delayed excitation of DLMs, observed in response to depolarizing currents delivered to wild-type (or Sh), absent in slo and spike amplitudes increased; these abnormalities phenocopied by reducing IC in normal muscle by injecting EGTA into such cells or using low-Ca2+ saline; the lengthened muscle action potentials in slo indicate importance of IC in effecting repolarization of such potentials.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079762 NM_170164 NM_206566 NM_001014651 NM_001014652 NM_001014653 NM_001014654 NM_001014655 NM_001014656 NM_001014657 NM_001014658 NM_001014659 NM_001014660 NM_001014661 NM_001014662 NM_001014663 NM_001014664 NM_001170241 NM_001275995 NM_001275996 NM_001275997 NM_001275998 NM_001275999 RefSeq (Proteins) • NP_524486 NP_733029 NP_996289 NP_001014651 NP_001014652 NP_001014653 NP_001014654 NP_001014655 NP_001014656 NP_001014657 NP_001014658 NP_001014659 NP_001014660 NP_001014661 NP_001014662 NP_001014663 NP_001014664 NP_001163712 NP_001262924 NP_001262925 NP_001262926 NP_001262927 NP_001262928 DDBJ / EMBL / GenBank • AA441418 AAA28651 AAA28902 AAC47020 AAC47021 AAF56324 AAF56324.1 AAL25313 AAN14013 AAN14013.1 AAO45232 AAS65211 AAS65211.1 AAX52977 AAX52978 AAX52979 AAX52980 AAX52981 AAX52982 AAX52983 AAX52984 AAX52985 AAX52986 AAX52987 AAX52988 AAX52989 AAX52990 ACZ95006 AGB96304 AGB96305 AGB96306 AGB96307 AGB96308 AI114075 AW940380 AW942413 AY060274 BT004876 CZ467771 CZ467921 CZ488541 M69053 M96840 U40221 U40314 U40315 Entrez Gene - A searchable database of RefSeq genes. • 42940 UniProtKB/Swiss-Prot • Q03720 UniProtKB/TrEMBL • E1JIV7 Q95T95
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Voltage-dependent potassium channel (IPR003091) Potassium channel, calcium-activated, BK, alpha subunit (IPR003929) Ion transport domain (IPR005821) NAD(P)-binding domain (IPR016040) Ion transport 2 (IPR013099) Calcium-activated potassium channel Slo (IPR024939) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD16342
Linkouts
	BioGRID - A database of protein and genetic interactions • 67865 DroID - A comprehensive database of gene and protein interactions. • FBgn0003429 DRSC - Results from RNAi screens. • FBgn0003429 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003429 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10693-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0003429 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42940 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /hjmuller/slowpk1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42940 modMine - Data generated by the modENCODE project. • FBgn0003429
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	BcDNA:GH10751   CG10693 (Whitfield, 2000.5.31, Graveley, 2004.4.19, Perkins et al., 2009.3.31, Keleman et al., 2009.8.5, Ni et al., 2008, Tsubouchi et al., 2012) dSlo (Derst et al., 2003, Zhou et al., 2002, Xu et al., 2004, Jaramillo et al., 2004, Zhou et al., 2003, Garcia-Valdes et al., 2001, Moss et al., 1999, Wang et al., 1999, Zhou et al., 1999, Moss et al., 1998, Myers and Stampe, 1998, Xia et al., 1998, Schopperle et al., 1998, Moss et al., 1997, Silberberg et al., 1996, Xia et al., 1996, Solaro et al., 1995, Meera et al., 1995, Shahidullah et al., 2009, Jaramillo et al., 2006, Gao et al., 2008, Ma et al., 2011) dslo (Garcia et al., 2001, Dopico et al., 1996) Dslo (Bian et al., 2001, Moczydlowski and Bian, 2001, Meera et al., 1997, Wallner et al., 1996, Moss et al., 1996) fSlo (Solaro et al., 1994) slo (Guan et al., 2005, Al-Hasan et al., 2008, Scholl et al., 2008, Li and Atkinson, 2008, Yu and Hardin, 2006, Brenner et al., 2000, Guan et al., 2011, Haerty et al., 2007, Sheldon et al., 2011, Wang et al., 2009, Jungreis et al., 2011, Peng and Wu, 2007, de la Paz Fernandez et al., 2007, Xu et al., 2005, Ranade et al., 2008, Wang et al., 2007, Wang et al., 2004, Pym et al., 2006, Hall, 2003, Qian and Bodmer, 2009, Shahidullah et al., 2009, Kuebler et al., 2001, Yang et al., 2008, Glazov et al., 2005, Lee et al., 2008, Ghezzi et al., 2010, Wasbrough et al., 2010, Gleason, 2005, Sandstrom, 2011, Tsubouchi et al., 2012, Berke et al., 2006, Jepson et al., 2012, Jungreis et al., 2011, Japanese National Institute of Genetics, 2012.5.21, Savva et al., 2012) Slo (Zeitouni et al., 2007, Joiner et al., 2007, Jaramillo et al., 2004, McCormack, 2003) Slo1 (Hou et al., 2008, Lee et al., 2010)
Name Synonym	slowpoke (Atkinson, 1992.9.28, Guan et al., 2005, Hall, 2002, Scholl et al., 2008, Yu and Hardin, 2006, Brenner et al., 2000, Joiner et al., 2007, Sheldon et al., 2011, de la Paz Fernandez et al., 2007, Xu et al., 2005, Moss et al., 1996, Hall, 2003, Qian and Bodmer, 2009, Kuebler et al., 2001, Glazov et al., 2005, Lee et al., 2008, Lee and Wu, 2010, Gleason, 2005, Tsubouchi et al., 2012, Kaplow et al., 2007, McCormack, 2003) Slowpoke (Crocker et al., 2010, Pym et al., 2006, Jaramillo et al., 2004, Jaramillo et al., 2006, Gao et al., 2008, Berke et al., 2006, McCormack, 2003)
Secondary FlyBase IDs
	FBgn0046797
References ( 204 )
Generate a list of	All references relating to this gene ( 204 )
List References by type	Research paper  ( 98 ) Supplementary material  ( 8 ) Review  ( 21 ) Personal communication to FlyBase  ( 17 ) Abstract  ( 51 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Stock list  ( 1 ) Curated genome annotation  ( 2 ) Website  ( 1 ) Conference report  ( 1 ) Letter  ( 1 )
Recent research papers ( 8 )
	Jepson et al., 2012, PLoS Genet. 8(4): e1002671 dyschronic, a Drosophila Homolog of a Deaf-Blindness Gene, Regulates Circadian Output and Slowpoke Channels. [FBrf0218124] Lagisz et al., 2012, Heredity 108(6): 602--608 Two distinct genomic regions, harbouring the period and fruitless genes, affect male courtship song in Drosophila montana. [FBrf0218390] Savva et al., 2012, Nat. Commun. 3: 790 Auto-regulatory RNA editing fine-tunes mRNA re-coding and complex behaviour in Drosophila. [FBrf0218141] Guan et al., 2011, Learn. Mem. 18(4): 191--206 Altered gene regulation and synaptic morphology in Drosophila learning and memory mutants. [FBrf0213277] Jungreis et al., 2011, Genome Res. 21(12): 2096--2113 Evidence of abundant stop codon readthrough in Drosophila and other metazoa. [FBrf0216845] Ma et al., 2011, J. Gen. Physiol. 137(2): 225--238 Slob, a Slowpoke channel-binding protein, modulates synaptic transmission. [FBrf0212896] Sandstrom, 2011, J. Neurogenet. 25(3): 104--114 Extracellular protons reduce quantal content and prolong synaptic currents at the Drosophila larval neuromuscular junction. [FBrf0215248] Sheldon et al., 2011, PLoS ONE 6(8): e23343 SLOB, a SLOWPOKE Channel Binding Protein, Regulates Insulin Pathway Signaling and Metabolism in Drosophila. [FBrf0214706] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...