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General Information
Symbol
Dmel\slp1
Species
D. melanogaster
Name
sloppy paired 1
Annotation Symbol
CG16738
Feature Type
FlyBase ID
FBgn0003430
Gene Model Status
Stock Availability
Gene Snapshot
sloppy paired 1 (slp1) encodes a transcription factor of the fork-head family that functions by interacting with the corepressor encoded by gro. The product of slp1 regulates a wide variety of developmental processes including embryonic segmentation, ventral fate specification in the retina, and temporal patterning of the neuroblasts that produce medulla neurons. [Date last reviewed: 2018-09-20]
Also Known As

slp, sloppy-paired, sloppy paired, FD6, slp-1

Key Links
Genomic Location
Cytogenetic map
Sequence location
2L:3,825,675..3,827,099 [+]
Recombination map

2-11

RefSeq locus
NT_033779 REGION:3825675..3827099
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Protein Family (UniProt)
-
Summaries
Gene Group (FlyBase)
FORK HEAD BOX TRANSCRIPTION FACTORS -
The forkhead box family of transcription factors are sequence-specific DNA binding proteins that regulate transcription. They are characterized by approximately 110 amino acid DNA-binding domain known as the forkhead or winged helix. (Adapted from FBrf0173142).
Protein Function (UniProtKB)
Transcription factor involved in segmentation. Required for the formation of the mandibular lobe. Different levels of slp activity seem to be required in different segments.
(UniProt, P32030)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
slp: sloppy paired
Embryonic lethal. Embryos lack parts of naked cuticle of T2, A1, A3, A5, and A7 in an irregular fashion. No effect of ftz expression (Carroll and Scott, 1986, Cell 45: 113-26).
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\slp1 or the JBrowse view of Dmel\slp1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0077499
1425
322
Additional Transcript Data and Comments
Reported size (kB)

1.5 (northern blot)

Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0077188
36.2
322
7.09
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments

The antibody used detects both slp1 and slp2.

External Data
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\slp1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (14 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000930906
(assigned by GO_Central )
Biological Process (11 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from mutant phenotype
inferred from expression pattern
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:bcd; FB:FBgn0000166
inferred from genetic interaction with FLYBASE:ems; FB:FBgn0000576
inferred from genetic interaction with FLYBASE:Kr; FB:FBgn0001325
inferred from genetic interaction with FLYBASE:Raf; FB:FBgn0003079
inferred from genetic interaction with FLYBASE:rl; FB:FBgn0003256
inferred from genetic interaction with FLYBASE:tor; FB:FBgn0003733
inferred from genetic interaction with FLYBASE:tsl; FB:FBgn0003867
inferred from genetic interaction with FLYBASE:dl; FB:FBgn0260632
Terms Based on Predictions or Assertions (7 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000930906
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000930906
(assigned by GO_Central )
traceable author statement
traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN000930906
(assigned by GO_Central )
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
inferred from direct assay
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000930906
(assigned by GO_Central )
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
organism | 70-80% egg length | dorsal

Comment: late stage 4; reference specifies 70-81% egg length

in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism | 70-90% egg length | ventral

Comment: reference states 71-87% egg length; late stage 4

dorsal ectoderm anlage

Comment: anlage in statu nascendi

mesoderm anlage

Comment: anlage in statu nascendi

ventral ectoderm anlage

Comment: anlage in statu nascendi

antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

antennal anlage

Comment: reported as procephalic ectoderm anlage

central brain anlage

Comment: reported as procephalic ectoderm anlage

dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

visual anlage

Comment: reported as procephalic ectoderm anlage

ventral nerve cord primordium

Comment: reported as ventral nerve cord anlage

northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

Expression was examined at four phases of embryonic stage 5. slp1 is initially expressed in a nonperiodic gap-like pattern in the anterior, which begins to resolve into stripes in phase 2 (5-17'); however, the full 7-stripe pattern arises only during phase 3 (17-30'). The stripes emerge fully refined, with sharp, evenly spaced stripes.

slp1 is expressed in 14 two-cell-wide stripes, corresponding to the two posterior-most cells in parasegments 1-13 as well as a stripe 0 that is anterior to parasegment 1. There is also expression in a band of dorsal cells anterior to the presegmental region.

slp1 transcripts first appear in 0-3hr embryos and show maximal expression in 3-6hr embryos. Levels fall off steadily until the end of embryogenesis. Transcripts are also expressed in first and third instar larvae. slp1 transcripts are first detected by in situ hybridization in a dynamic gap-gene-like pattern in stage 4 embryos. From stage 5, a metameric pattern develops with six 2-cell-wide stripes appearing posterior to the head stripe. The anterior stripes appear first, followed by more posterior stripes. Stripes also develop ventrally first and then spread dorsally. The stripes remain unconnected on the dorsal side. After the primary stripes are fully established, secondary stripes develop in alternate segments. They also accumulate from anterior to posterior. They are detected laterally first and then spread in the dorsal and ventral directions but never connect on the dorsal side. By stage 6, the secondary stripes are established. They are weaker and don't extend as far dorsally as the primary stripes. During germ band extension, the stripes broaden to 4-5 cells and an additional stripe appears at the tip of the germ band. Segmentally repeated lateral cell clusters that are connected to the ventral stripes by thin stalks also express slp1. A complex pattern of slp1 expression is also observed in the head during germ band extension. The metameric pattern fades as the germ band retracts. Expression is lost in the stalk regions connecting the lateral clusters. New expression is observed in epidermal cells forming ventrolateral oblong cell clusters and in dorsal epidermal cells that will fuse at the dorsal midline. This staining fades as dorsal closure is completed. slp1 expression is also observed after germ band retraction in the proventriculus and in the ventral nerve cord. The patterns of slp1 and slp2 gene expression are very similar but slp2 expression is slightly time delayed relative to slp1 and has minor spatial differences. Double labeling with slp and either ftz, en, or eve probes reveals that slp1 and slp2 are expressed in the posterior half of each parasegment just anterior to the parasegmental boundary.

slp1 transcripts are expressed in a gap gene pattern, then a pair-rule stripe pattern, then a segment polarity gene pattern in early embryos. The same pattern is observed for slp2 transcripts.

Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

slp1 protein is expressed in the same subset of medulla forming neuroblasts as slp2.

slp1-protein is expressed in the developing larval medulla in intermediate neuroblasts, which weakly co-express klu-protein. The expression level of slp1-protein gradually decreases from lateral to medial neuroblasts.

At embryonic stage 11, slp1 is localized to the anterior compartment of segments.

Expression in procephalic neuroblasts stage 9-11: tritocerebrum - d2, d6, d7, v3; deuterocerebrum - d1, d4, d7, d8, v2, v3, v5, v6; protocerebrum - ad2, ad8, d8, cd9, cd12, cd19, cv4, cv6, cv8, pd1, pd11, pd15, pd16, pv1, pv3

Stripes alternate with bap and coincide with eve.

At cellular blastoderm, slp1 protein is found in the posterior portion of each even-numbered parasegment, adjacent to but not overlapping eve protein. During gastrulation, secondary stripes appear, just anterior to the ftz stripes. During germband elongation, every parasegment has a slp1 protein stripe adjacent to en, overlapping wg and extending anterior. At stage 10, this stripe is 3-4 cells wide.

Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\slp1 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 10 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 21 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of slp1
Transgenic constructs containing regulatory region of slp1
Deletions and Duplications ( 14 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
embryonic/first instar larval cuticle & abdominal segment 1
embryonic/first instar larval cuticle & abdominal segment 3
embryonic/first instar larval cuticle & abdominal segment 5
embryonic/first instar larval cuticle & abdominal segment 7
embryonic/first instar larval cuticle & mesothoracic segment
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (32)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
7 of 15
Yes
No
3 of 15
No
No
3 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
 
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
Yes
2 of 15
No
No
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (27)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
6 of 15
Yes
No
3 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
Yes
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (26)
5 of 13
Yes
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
Yes
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (28)
2 of 12
Yes
No
2 of 12
Yes
No
2 of 12
Yes
No
2 of 12
Yes
No
2 of 12
Yes
Yes
2 of 12
Yes
Yes
2 of 12
Yes
No
2 of 12
Yes
Yes
2 of 12
Yes
Yes
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
Yes
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
Yes
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
Yes
1 of 12
No
No
1 of 12
No
Yes
1 of 12
No
Yes
Danio rerio (Zebrafish) (44)
6 of 15
Yes
No
6 of 15
Yes
No
5 of 15
No
No
5 of 15
No
No
3 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
Yes
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
Yes
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (9)
8 of 15
Yes
No
3 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (3)
4 of 15
Yes
No
3 of 15
No
No
3 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (4)
5 of 12
Yes
Yes
4 of 12
No
Yes
2 of 12
No
No
2 of 12
No
No
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190F48 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091509RJ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0H9B )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0HB5 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0JF7 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (12)
5 of 10
3 of 10
3 of 10
3 of 10
3 of 10
3 of 10
3 of 10
2 of 10
2 of 10
1 of 10
1 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser

    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    2L
    Recombination map

    2-11

    Cytogenetic map
    Sequence location
    2L:3,825,675..3,827,099 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    24C6-24C6
    Limits computationally determined from genome sequence between P{EP}EP2595EP2595 and P{lacW}edk01102
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    24C8-24D1
    (determined by in situ hybridisation)
    24D-24D
    (determined by in situ hybridisation)
    Experimentally Determined Recombination Data
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (13)
    Genomic Clones (9)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (13)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
     
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for database merge of
    Additional comments
    Other Comments

    Class IV neuron formation is suppressed by slp1.

    DNA-protein interactions: genome-wide binding profile assayed for slp1 protein in 2-3 hr embryos; see BDTNP1_TFBS_slp1 collection report.

    The EH1 gro binding site is required for slp1-mediated repression.

    slp1 and slp2 function downstream of wg signaling to generate the NB4-2 cell.

    wg and slp1/slp2 act in a common pathway in which slp1/slp2 serves as a direct target of wg signals that mediates wg effects in both ectoderm and mesoderm. slp1/slp2 act downstream of wg to repress bap and visceral mesoderm formation.

    Induction of slp1 by wg involves pan binding to multiple binding sites within a wg-responsive enhancer in the 5' region of slp1. wg signalling induces striped expression of slp1/slp2 in the mesoderm, providing striped mesodermal domains competent to respond to subsequent slp1/slp2-independent wg signals that induce somatic muscle and heart progenitors. In wg expressing ectodermal cells, slp1/slp2 is an integral component in an autocrine feedback loop of wg signalling.

    slp1 protein may be a direct repressor of the ftz gene in developing embryos.

    In a sample of 79 genes with multiple introns, 33 showed significant heterogeneity in G+C content among introns of the same gene and significant positive correspondence between the intron and the third codon position G+C content within genes. These results are consistent with selection adding against preferred codons at the start of genes.

    slp1 and slp2 control all aspects of differentiation in the slp domain, including segmental repression of bap, maintenance of high levels of twi and hence myogenesis.

    slp1 is an activator of wg and a repressor of en and through these activities the distribution of slp1 defines en-competent cells (lacking slp1 protein) and wg-competent cells (containing slp1 protein). The localised expression of slp1 is required to maintain the proper anterior border of the en stripes and restrict wg expression to one side of the en/hh domain.

    One of the major targets of slp1 action is the wg gene.

    slp1 plays a predominent role in head formation while slp2 is largely dispensible.

    slp1 and slp2 are regulated by a common enhancer region upstream of slp1. slp1/slp2 act as a head-specific gap gene in addition to the function as a pair-rule and segment polarity gene in the trunk.

    Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5.

    One copy of slp2 is sufficient to ensure proper segmentation of the even numbered abdominal segments in a slp1- background. slp1 and slp2 are not equivalent as only one copy of each is required for viability.

    slp1/slp2 function is required to set up expression of ac in row B of the embryonic proneural cluster.

    Mutations in zygotic pair rule gene slp1 do not interact with RpII140wimp.

    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 46 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
    KEGG Genes - Molecular building blocks of life in the genomic space.
    modMine - A data warehouse for the modENCODE project
    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DPiM - Drosophila Protein interaction map
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
    FlyMine - An integrated database for Drosophila genomics
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Synonyms and Secondary IDs (29)
    Reported As
    Symbol Synonym
    l(2)05965
    slp
    (Clark et al., 2019, Sapar and Han, 2019, Mbodj et al., 2016, Ettensohn, 2013, Jin et al., 2013, Suzuki et al., 2013, Webber et al., 2013, He et al., 2012, Kaplan et al., 2011, Karim and Moore, 2011, Schroeder et al., 2011, Itasaki and Hoppler, 2010, Goering et al., 2009, Kozlov et al., 2009, Myasnikova et al., 2009, Pisarev et al., 2009, Schaaf et al., 2009, Blanco and Gehring, 2008, Larsen et al., 2008, Surkova et al., 2008, Surkova et al., 2008, Gebelein and Mann, 2007, Lindner et al., 2007, Rakovitsky et al., 2007, Sandmann et al., 2007, Sato and Tomlinson, 2007, Goldstein et al., 2005, Ochoa-Espinosa et al., 2005, Buescher et al., 2004, Furlong, 2004, Ingolia, 2004, Jaynes and Fujioka, 2004, Albert and Othmer, 2003, Kobayashi et al., 2003, Sanchez and Thieffry, 2003, Thieffry and Sanchez, 2003, Vander Zwan and Gergen, 2003, Vander Zwan et al., 2003, Cripps and Olson, 2002, Fujioka et al., 2002, Galis et al., 2002, Walrad et al., 2002, Kobayashi et al., 2001, Kobayashi et al., 2001, Lee et al., 2001, Myasnikova et al., 2001, Lee and Frasch, 2000, Lee and Frasch, 2000, Nasiadka et al., 2000, Piepenburg et al., 2000, Rusch and Kaufman, 2000, Schuldt, 2000, Bowler et al., 1999, Frasch, 1999, Jack and Myette, 1999, Kobayashi et al., 1999, Muller et al., 1999, Paululat et al., 1999, Wilson, 1999, Baylies et al., 1998, Kosman et al., 1998, Ruiz-Gomez, 1998, Saulier-Le Drean et al., 1998, Struhl et al., 1997, Goriely et al., 1996, Ma et al., 1996, Miskiewicz et al., 1996, Park et al., 1996, Fujioka et al., 1995, Harbecke and Lengyel, 1995, Fietz et al., 1994, de Belle et al., 1993, Jackle and Sauer, 1993, Kornberg and Tabata, 1993, Martinez Arias, 1993, Pankratz and Jäckle, 1993, Topol et al., 1991, Bellen et al., 1989, Coulter and Wieschaus, 1988, Jack et al., 1988, DiNardo and O'Farrell, 1987, Frasch and Levine, 1987, Tearle and Nusslein-Volhard, 1987)
    slp1
    (Seong et al., 2019, Shokri et al., 2019, Andrioli et al., 2017, Hang and Gergen, 2017, Hauptmann et al., 2016, Urbach et al., 2016, Williams et al., 2016, Lee et al., 2015, model organism Encyclopedia of Regulatory Network (modERN) Project, 2015-, Schertel et al., 2015, Spratford and Kumar, 2015, Ghavi-Helm et al., 2014, Jiang and Singh, 2014, Slattery et al., 2014, Chen et al., 2013, Combs and Eisen, 2013, Jennings, 2013, Li and Gilmour, 2013, Saunders et al., 2013, Andrioli et al., 2012, Aswani et al., 2012, Busser et al., 2012, Chen et al., 2012, Fujioka and Jaynes, 2012, He et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Kim et al., 2012, Nikulova et al., 2012, Reim et al., 2012, Yuan et al., 2012, Zhu et al., 2012, Karim and Moore, 2011, Li et al., 2011, Nègre et al., 2011, Ntini and Wimmer, 2011, Pruteanu-Malinici et al., 2011, Schroeder et al., 2011, Tsurumi et al., 2011, Walrad et al., 2011, Neely et al., 2010, Prazak et al., 2010, Sen et al., 2010, Walrad et al., 2010, Wang et al., 2010, Gutierrez-Aviño et al., 2009, Liu et al., 2009, Ochoa-Espinosa et al., 2009, Southall and Brand, 2009, Fowlkes et al., 2008, Gergen et al., 2008, Hare et al., 2008, Halfon and Arnosti, 2007, Jakobsen et al., 2007, Mondal et al., 2007, Nekrasov et al., 2007, Sato and Tomlinson, 2007, Stuart et al., 2007, Vanderzwan-Butler et al., 2007, Wang and Gergen, 2007, Wang et al., 2007, Choksi et al., 2006, Luengo Hendriks et al., 2006, Sandmann et al., 2006, Copley, 2005, Grad et al., 2004, Gurunathan et al., 2004, Lee and Frasch, 2004)
    Secondary FlyBase IDs
    • FBgn0010610
    Datasets (3)
    Study focus (3)
    Experimental Role
    Project
    Project Type
    Title
    • bait_protein
    ChIP-chip identification of binding sites for transcription factors that regulate mesodermal development.
    • bait_protein
    ChIP characterization of transcription factor genome binding, Berkeley Drosophila Transcription Factor Network Project.
    • bait_protein
    Genome-wide localization of transcription factors by ChIP-chip and ChIP-Seq.
    References (323)