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Gene Dmel\slp1

General Information
Symbol	Dmel\slp1	Species	D. melanogaster
Name	sloppy paired 1	Annotation symbol	CG16738
Feature type	protein_coding_gene	FlyBase ID	FBgn0003430
Gene Model Status	Current	Stock availability	16 publicly available
Also Known As	slp, Slp-1, FD6
Genomic Location
Chromosome (arm)	2L	Recombination map	2-8
Cytogenetic map	24C6-24C6	Sequence location	2L:3,825,680..3,827,137 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene sloppy paired 1 is referred to in FlyBase by the symbol Dmel\slp1 (CG16738, FBgn0003430). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: sequence-specific distal enhancer binding RNA polymerase II transcription factor activity. There is experimental evidence that it is involved in the biological process: heart formation; specification of segmental identity, head; negative regulation of transcription from RNA polymerase II promoter. 22 alleles are reported. The phenotypes of these alleles are annotated with: organ system; primordium; ventral nerve cord primordium; organ system subdivision; cephalopharyngeal skeleton; cuticle; somatic stem cell; eo support cell; mouthpart; embryonic segment; neuroblast NB5-6. It has one annotated transcript and one annotated polypeptide. Protein features are: Transcription factor, fork head; Transcription factor, fork head, conserved site; Winged helix-turn-helix transcription repressor DNA-binding. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult thoracico-abdominal ganglion. Comments on Affy2 ProbeSet: ProbeSet 1640129_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of slp1. Gene sequence location is 2L:3825680..3827137.
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	slp: sloppy paired Embryonic lethal. Embryos lack parts of naked cuticle of T2, A1, A3, A5, and A7 in an irregular fashion. No effect of ftz expression (Carroll and Scott, 1986, Cell 45: 113-26).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Gurunathan et al., 2004, BMC Bioinformatics 5: 202 Grad et al., 2004, Bioinformatics 20(16): 2738--2750 Zamparo and Perkins, 2009, Bioinformatics 25(20): 2670--2676
FB2012_01	Sequence features BKN26295 HFA00835 Controlled Vocabulary Terms negative regulation of transcription from RNA polymerase II promoter sequence-specific distal enhancer binding RNA polymerase II transcription factor activity
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 24C6-24C6   Limits computationally determined from genome sequence between P{EP}EP2595EP2595 and P{lacW}edk01102
Experimentally Determined Cytological Location
Cytogenetic map Notes References 24C8-24D1   (determined by in situ hybridisation)   (Spradling et al., 1999) 24C8-24D1     (BDGP Project Members, 1994-1999) 24D-24D   (determined by in situ hybridisation)   (Hacker et al., 1992) 24D-24D   (determined by in situ hybridisation)   (Grossniklaus et al., 1992)
Experimentally Determined Recombination Data
Location	2-8 (Tearle and Nusslein-Volhard, 1987, )
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\slp1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) slp1-RA FBtr0077499  NM_057382   1458   322
Additional Transcript Data & Comments
Reported size (kB)	1.5 (northern blot) (Grossniklaus et al., 1992)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein slp1-PA   FBpp0077188   36.2   322   7.09     NP_476730   AAF51058
Additional Polypeptide Data & Comments
Reported size (kDa)	322 (aa) (Grossniklaus et al., 1992)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Transcription factor, fork head, conserved site (IPR018122) Transcription factor, fork head (IPR001766) Winged helix-turn-helix transcription repressor DNA-binding (IPR011991)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014134 AAF51058   AC004781   AC005732   AC010694   AC092240   AI063986   AI064327   AI401964   AQ025644   AY047536 AAK77268   BI232298   BI235626   BQ103019   BQ103023   CO189049   CO189603   CO189856   CO196575   CO262344   EC057913   EC070545   EC089811   EC195424   EC195440   EC224701   EC240249   X66095 CAA46889   X66096 CAA46890
UniProtKB/Swiss-Prot	P32030
UniProtKB/TrEMBL	Q961V5
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References protein binding site FBsf0000160470 2L:3,824,297..3,824,322 bound_moiety=pan-XP evidence=experimental (Bergman et al., 2004, Lee and Frasch, 2000) protein binding site FBsf0000160471 2L:3,824,346..3,824,366 bound_moiety=pan-XP evidence=experimental (Lee and Frasch, 2000, Bergman et al., 2004) protein binding site FBsf0000160472 2L:3,823,277..3,823,296 evidence=experimental bound_moiety=pan-XP (Bergman et al., 2004, Lee and Frasch, 2000) protein binding site FBsf0000160473 2L:3,823,447..3,823,469 bound_moiety=pan-XP evidence=experimental (Bergman et al., 2004, Lee and Frasch, 2000) protein binding site FBsf0000160474 2L:3,824,023..3,824,048 bound_moiety=pan-XP evidence=experimental (Lee and Frasch, 2000, Bergman et al., 2004) protein binding site FBsf0000160475 2L:3,823,211..3,823,236 bound_moiety=pan-XP evidence=experimental (Lee and Frasch, 2000, Bergman et al., 2004) protein binding site FBsf0000160476 2L:3,823,994..3,824,018 bound_moiety=pan-XP evidence=experimental (Bergman et al., 2004, Lee and Frasch, 2000) protein binding site FBsf0000160477 2L:3,824,209..3,824,226 bound_moiety=pan-XP evidence=experimental (Lee and Frasch, 2000, Bergman et al., 2004) protein binding site FBsf0000160478 2L:3,824,173..3,824,195 bound_moiety=pan-XP evidence=experimental (Bergman et al., 2004, Lee and Frasch, 2000)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism | pair rule expression pattern   (Hacker et al., 1992) embryonic stage 4   organism | 70-80% egg length & dorsal   (Grossniklaus et al., 1992) Comment:late stage 4; reference specifies 70-81% egg length embryonic stage 5   organism | even pair rule expression pattern   (Grossniklaus et al., 1992) embryonic stage 8 -- 17   intercalary segment   (Grossniklaus et al., 1992) embryonic procephalic segment | lateral   (Grossniklaus et al., 1992) embryonic stage 13 -- 17   embryonic/larval proventriculus   (Grossniklaus et al., 1992) in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism | gap expression pattern   (Hacker et al., 1992) organism | segment polarity expression pattern   (Hacker et al., 1992) embryonic stage 4   organism | 70-90% egg length & ventral   (Grossniklaus et al., 1992) Comment:reference states 71-87% egg length; late stage 4 northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage 4   organism | 70-100% egg length   (Grossniklaus et al., 1992) embryonic stage 6   organism | segment polarity expression pattern   (Grossniklaus et al., 1992) embryonic stage 8 -- 17   labral segment   (Grossniklaus et al., 1992) mandibular segment   (Grossniklaus et al., 1992) embryonic stage 13 -- 17   ventral nerve cord   (Grossniklaus et al., 1992)
Additional Descriptive Data
	slp1 transcripts are expressed in a gap gene pattern, then a pair-rule stripe pattern, then a segment polarity gene pattern in early embryos. The same pattern is observed for slp2 transcripts. (Hacker et al., 1992) slp1 transcripts first appear in0-3hr embryos and show maximal expression in 3-6hr embryos. Levels falloff steadily until the end of embryogenesis. Transcripts are alsoexpressed in first and third instar larvae. slp1 transcripts are firstdetected by in situ hybridization in a dynamic gap-gene-like pattern instage 4 embryos. From stage 5, a metameric pattern develops with six2-cell-wide stripes appearing posterior to the head stripe. The anteriorstripes appear first followed by more posterior stripes. Stripes alsodevelop ventrally first and then spread dorsally. The stripes remainunconnected on the dorsal side. After the primary stripes are fullyestablished, secondary stripes develop in alternate segments. They alsoaccumulate from anterior to posterior. They are detected laterally firstand then spread in the dorsal and ventral directions but never connect onthe dorsal side. By stage 6, the secondary stripes are established. Theyare weaker and don't extend as far dorsally as the primary stripes. Duringgerm band extension, the stripes broaden to 4-5 cells and an additionalstripe appears at the tip of the germ band. Segmentally repeated lateralcell clusters that are connected to the ventral stripes by thin stalksalso express slp1. A complex pattern of slp1 expression is alsoobserved in the head during germ band extension. The metameric patternfades as the germ band retracts. Expression is lost in the stalk regionsconnecting the lateral clusters. New expression is observed in epidermalcells forming ventrolateral oblong cell clusters and in dorsal epidermalcells that will fuse at the dorsal midline. This staining fades as dorsalclosure is completed. slp1 expression is also observed after germ bandretraction in the proventriculus and in the ventral nerve cord. Thepatterns of slp1 and slp2 gene expression are very similar but slp2expression is slightly time delayed relative to slp1 and has minorspatial differences. Double labeling with slp and either ftz, en, oreve probes reveals that slp1 and slp2 are expressed in the posteriorhalf of each parasegment just anterior to the parasegmental boundary. (Grossniklaus et al., 1992)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 5   organism | even pair rule expression pattern   (Cadigan et al., 1994) embryonic stage 6 -- 7   organism | segment polarity expression pattern   (Cadigan et al., 1994) embryonic stage 8 -- 11   procephalic neurogenic region & embryonic antennal segment | restricted   (Urbach and Technau, 2003) Comment:stripe of expression procephalic neurogenic region & embryonic mandibular segment | restricted   (Urbach and Technau, 2003) Comment:stripe of expression embryonic stage 9 -- 11   procephalic neurogenic region & embryonic ocular segment | restricted   (Urbach and Technau, 2003) procephalic neurogenic region & intercalary segment | restricted   (Urbach and Technau, 2003) Comment:stripe of expression protocerebral neuroblast | subset   (Urbach and Technau, 2003) tritocerebral neuroblast | subset   (Urbach and Technau, 2003) deuterocerebral neuroblast | subset   (Urbach and Technau, 2003) procephalic neurogenic region & labral segment | restricted   (Urbach and Technau, 2003) embryonic stage 10   organism | striped   (Lee and Frasch, 2000) embryonic stage 11   organism | segmentally repeated   (Gebelein et al., 2004, Bhat et al., 2000)
Additional Descriptive Data
	At cellular blastoderm, slp1 protein is found in the posterior portion of each even-numbered parasegment, adjacent to but not overlapping eve protein. During gastrulation, secondary stripes appear, just anterior to the ftz stripes. During germband elongation, every parasegment has a slp1 protein stripe adjacent to en, overlapping wg and extending anterior. At stage 10, this stripe is 3-4 cells wide. (Cadigan et al., 1994) At embryonic stage 11, slp1 is localized to the anterior compartment of segments. (Gebelein et al., 2004) Stripes alternate with bap and coincide with eve. (Lee and Frasch, 2000) Expression in procephalic neuroblasts stage 9-11: tritocerebrum - d2, d6, d7, v3; deuterocerebrum - d1, d4, d7, d8, v2, v3, v5, v6; protocerebrum - ad2, ad8, d8, cd9, cd12, cd19, cv4, cv6, cv8, pd1, pd11, pd15, pd16, pv1, pv3 (Urbach and Technau, 2003)
Marker for
Subcellular Localization
CV Term	nucleus (Cadigan et al., 1994)
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0003430    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0003430 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0003430 expression level Developmental Stage   Expression Level embryo 00-02hr    301 embryo 02-04hr    4402 embryo 04-06hr    9845 embryo 06-08hr    5881 embryo 08-10hr    2948 embryo 10-12hr    3525 embryo 12-14hr    2570 embryo 14-16hr    1024 embryo 16-18hr    659 embryo 18-20hr    420 embryo 20-22hr    225 embryo 22-24hr    317 larva L1    187 larva L2    130 larva L3 12hr old    54 larva L3 puffstage 1-2    94 larva L3 puffstage 3-6    185 larva L3 puffstage 7-9    240 white prepupae new    234 white prepupae 12hr    270 white prepupae 24hr    505 pupae 2d postWPP    254 pupae 3d postWPP    114 pupae 4d postWPP    68 adult male 01day    86 adult male 05day    116 adult male 30day    155 adult female 01day    61 adult female 05day    21 adult female 30day    26 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (301) embryo 02-04hr  (4402) embryo 04-06hr  (9845) embryo 06-08hr  (5881) embryo 08-10hr  (2948) embryo 10-12hr  (3525) embryo 12-14hr  (2570) embryo 14-16hr  (1024) embryo 16-18hr  (659) embryo 18-20hr  (420) embryo 20-22hr  (225) embryo 22-24hr  (317) larva L1  (187) larva L2  (130) larva L3 12hr old    54 larva L3 puffstage 1-2    94 larva L3 puffstage 3-6  (185) larva L3 puffstage 7-9  (240) white prepupae new  (234) white prepupae 12hr  (270) white prepupae 24hr  (505) pupae 2d postWPP  (254) pupae 3d postWPP  (114) pupae 4d postWPP    68 adult male 01day    86 adult male 05day  (116) adult male 30day  (155) adult female 01day    61 adult female 05day    21 adult female 30day    26 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    301 embryo 02-04hr  (4402) embryo 04-06hr  (9845) embryo 06-08hr  (5881) embryo 08-10hr  (2948) embryo 10-12hr  (3525) embryo 12-14hr  (2570) embryo 14-16hr    1024 embryo 16-18hr    659 embryo 18-20hr    420 embryo 20-22hr    225 embryo 22-24hr    317 larva L1    187 larva L2    130 larva L3 12hr old    54 larva L3 puffstage 1-2    94 larva L3 puffstage 3-6    185 larva L3 puffstage 7-9    240 white prepupae new    234 white prepupae 12hr    270 white prepupae 24hr    505 pupae 2d postWPP    254 pupae 3d postWPP    114 pupae 4d postWPP    68 adult male 01day    86 adult male 05day    116 adult male 30day    155 adult female 01day    61 adult female 05day    21 adult female 30day    26 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    301 embryo 02-04hr    4402 embryo 04-06hr    9845 embryo 06-08hr    5881 embryo 08-10hr    2948 embryo 10-12hr    3525 embryo 12-14hr    2570 embryo 14-16hr    1024 embryo 16-18hr    659 embryo 18-20hr    420 embryo 20-22hr    225 embryo 22-24hr    317 larva L1    187 larva L2    130 larva L3 12hr old    54 larva L3 puffstage 1-2    94 larva L3 puffstage 3-6    185 larva L3 puffstage 7-9    240 white prepupae new    234 white prepupae 12hr    270 white prepupae 24hr    505 pupae 2d postWPP    254 pupae 3d postWPP    114 pupae 4d postWPP    68 adult male 01day    86 adult male 05day    116 adult male 30day    155 adult female 01day    61 adult female 05day    21 adult female 30day    26 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    301 embryo 02-04hr    4402 embryo 04-06hr    9845 embryo 06-08hr    5881 embryo 08-10hr    2948 embryo 10-12hr    3525 embryo 12-14hr    2570 embryo 14-16hr    1024 embryo 16-18hr    659 embryo 18-20hr    420 embryo 20-22hr    225 embryo 22-24hr    317 larva L1    187 larva L2    130 larva L3 12hr old    54 larva L3 puffstage 1-2    94 larva L3 puffstage 3-6    185 larva L3 puffstage 7-9    240 white prepupae new    234 white prepupae 12hr    270 white prepupae 24hr    505 pupae 2d postWPP    254 pupae 3d postWPP    114 pupae 4d postWPP    68 adult male 01day    86 adult male 05day    116 adult male 30day    155 adult female 01day    61 adult female 05day    21 adult female 30day    26 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0003430 expression level Developmental Stage   Expression Level embryo 00-02hr    301 embryo 02-04hr    4402 embryo 04-06hr    9845 embryo 06-08hr    5881 embryo 08-10hr    2948 embryo 10-12hr    3525 embryo 12-14hr    2570 embryo 14-16hr    1024 embryo 16-18hr    659 embryo 18-20hr    420 embryo 20-22hr    225 embryo 22-24hr    317 larva L1    187 larva L2    130 larva L3 12hr old    54 larva L3 puffstage 1-2    94 larva L3 puffstage 3-6    185 larva L3 puffstage 7-9    240 white prepupae new    234 white prepupae 12hr    270 white prepupae 24hr    505 pupae 2d postWPP    254 pupae 3d postWPP    114 pupae 4d postWPP    68 adult male 01day    86 adult male 05day    116 adult male 30day    155 adult female 01day    61 adult female 05day    21 adult female 30day    26 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (301) embryo 02-04hr  (4402) embryo 04-06hr  (9845) embryo 06-08hr  (5881) embryo 08-10hr  (2948) embryo 10-12hr  (3525) embryo 12-14hr  (2570) embryo 14-16hr  (1024) embryo 16-18hr  (659) embryo 18-20hr  (420) embryo 20-22hr  (225) embryo 22-24hr  (317) larva L1  (187) larva L2  130 larva L3 12hr old    54 larva L3 puffstage 1-2    94 larva L3 puffstage 3-6  (185) larva L3 puffstage 7-9  (240) white prepupae new  (234) white prepupae 12hr  (270) white prepupae 24hr  (505) pupae 2d postWPP  (254) pupae 3d postWPP  114 pupae 4d postWPP    68 adult male 01day    86 adult male 05day  116 adult male 30day  (155) adult female 01day    61 adult female 05day    21 adult female 30day    26 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    301 embryo 02-04hr  (4402) embryo 04-06hr  (9845) embryo 06-08hr  (5881) embryo 08-10hr  (2948) embryo 10-12hr  (3525) embryo 12-14hr  (2570) embryo 14-16hr    1024 embryo 16-18hr    659 embryo 18-20hr    420 embryo 20-22hr    225 embryo 22-24hr    317 larva L1    187 larva L2    130 larva L3 12hr old    54 larva L3 puffstage 1-2    94 larva L3 puffstage 3-6    185 larva L3 puffstage 7-9    240 white prepupae new    234 white prepupae 12hr    270 white prepupae 24hr    505 pupae 2d postWPP    254 pupae 3d postWPP    114 pupae 4d postWPP    68 adult male 01day    86 adult male 05day    116 adult male 30day    155 adult female 01day    61 adult female 05day    21 adult female 30day    26 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    301 embryo 02-04hr    4402 embryo 04-06hr    9845 embryo 06-08hr    5881 embryo 08-10hr    2948 embryo 10-12hr    3525 embryo 12-14hr    2570 embryo 14-16hr    1024 embryo 16-18hr    659 embryo 18-20hr    420 embryo 20-22hr    225 embryo 22-24hr    317 larva L1    187 larva L2    130 larva L3 12hr old    54 larva L3 puffstage 1-2    94 larva L3 puffstage 3-6    185 larva L3 puffstage 7-9    240 white prepupae new    234 white prepupae 12hr    270 white prepupae 24hr    505 pupae 2d postWPP    254 pupae 3d postWPP    114 pupae 4d postWPP    68 adult male 01day    86 adult male 05day    116 adult male 30day    155 adult female 01day    61 adult female 05day    21 adult female 30day    26 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    301 embryo 02-04hr    4402 embryo 04-06hr    9845 embryo 06-08hr    5881 embryo 08-10hr    2948 embryo 10-12hr    3525 embryo 12-14hr    2570 embryo 14-16hr    1024 embryo 16-18hr    659 embryo 18-20hr    420 embryo 20-22hr    225 embryo 22-24hr    317 larva L1    187 larva L2    130 larva L3 12hr old    54 larva L3 puffstage 1-2    94 larva L3 puffstage 3-6    185 larva L3 puffstage 7-9    240 white prepupae new    234 white prepupae 12hr    270 white prepupae 24hr    505 pupae 2d postWPP    254 pupae 3d postWPP    114 pupae 4d postWPP    68 adult male 01day    86 adult male 05day    116 adult male 30day    155 adult female 01day    61 adult female 05day    21 adult female 30day    26 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0003430    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0003430 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult thoracico-abdominal ganglion. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0003430 expression level Tissue   Expression Level Larval Central Nervous System    98.525 Larval Midgut    4.4 Larval Hindgut    3.6 Larval Malpighian Tubules    2.8 Larval Fat Body    2.4 Larval Salivary Gland    1 Larval Trachea    5.475 Larval Carcass no informative data Adult Head    58.3 Adult Eye    115.175 Adult Brain    83.1 Adult Thoracic-Abdominal Ganglion    112.9 Adult Crop    6.6 Adult Midgut    2.9 Adult Hindgut    6.4 Adult Malpighian Tubules    4.2 Adult Fat Body    9.3 Adult Salivary Gland no informative data Adult Heart    2.125 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    0.9 Adult Testis    3.7 Adult Male Accessory Gland    8.7 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    98.525 Larval Midgut    4.4 Larval Hindgut    3.6 Larval Malpighian Tubules    2.8 Larval Fat Body    2.4 Larval Salivary Gland    1 Larval Trachea    5.475 Larval Carcass no informative data Adult Head    58.3 Adult Eye    115.175 Adult Brain    83.1 Adult Thoracic-Abdominal Ganglion    112.9 Adult Crop    6.6 Adult Midgut    2.9 Adult Hindgut    6.4 Adult Malpighian Tubules    4.2 Adult Fat Body    9.3 Adult Salivary Gland no informative data Adult Heart    2.125 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    0.9 Adult Testis    3.7 Adult Male Accessory Gland    8.7 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    98.525 Larval Midgut    4.4 Larval Hindgut    3.6 Larval Malpighian Tubules    2.8 Larval Fat Body    2.4 Larval Salivary Gland    1 Larval Trachea    5.475 Larval Carcass no informative data Adult Head    58.3 Adult Eye    115.175 Adult Brain    83.1 Adult Thoracic-Abdominal Ganglion    112.9 Adult Crop    6.6 Adult Midgut    2.9 Adult Hindgut    6.4 Adult Malpighian Tubules    4.2 Adult Fat Body    9.3 Adult Salivary Gland no informative data Adult Heart    2.125 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    0.9 Adult Testis    3.7 Adult Male Accessory Gland    8.7 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    98.525 Larval Midgut    4.4 Larval Hindgut    3.6 Larval Malpighian Tubules    2.8 Larval Fat Body    2.4 Larval Salivary Gland    1 Larval Trachea    5.475 Larval Carcass no informative data Adult Head    58.3 Adult Eye    115.175 Adult Brain    83.1 Adult Thoracic-Abdominal Ganglion    112.9 Adult Crop    6.6 Adult Midgut    2.9 Adult Hindgut    6.4 Adult Malpighian Tubules    4.2 Adult Fat Body    9.3 Adult Salivary Gland no informative data Adult Heart    2.125 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    0.9 Adult Testis    3.7 Adult Male Accessory Gland    8.7 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0003430 expression level Tissue   Expression Level Larval Central Nervous System    98.525 Larval Midgut    4.4 Larval Hindgut    3.6 Larval Malpighian Tubules    2.8 Larval Fat Body    2.4 Larval Salivary Gland    1 Larval Trachea    5.475 Larval Carcass no informative data Adult Head    58.3 Adult Eye    115.175 Adult Brain    83.1 Adult Thoracic-Abdominal Ganglion    112.9 Adult Crop    6.6 Adult Midgut    2.9 Adult Hindgut    6.4 Adult Malpighian Tubules    4.2 Adult Fat Body    9.3 Adult Salivary Gland no informative data Adult Heart    2.125 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    0.9 Adult Testis    3.7 Adult Male Accessory Gland    8.7 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    98.525 Larval Midgut    4.4 Larval Hindgut    3.6 Larval Malpighian Tubules    2.8 Larval Fat Body    2.4 Larval Salivary Gland    1 Larval Trachea    5.475 Larval Carcass no informative data Adult Head    58.3 Adult Eye    115.175 Adult Brain    83.1 Adult Thoracic-Abdominal Ganglion    112.9 Adult Crop    6.6 Adult Midgut    2.9 Adult Hindgut    6.4 Adult Malpighian Tubules    4.2 Adult Fat Body    9.3 Adult Salivary Gland no informative data Adult Heart    2.125 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    0.9 Adult Testis    3.7 Adult Male Accessory Gland    8.7 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    98.525 Larval Midgut    4.4 Larval Hindgut    3.6 Larval Malpighian Tubules    2.8 Larval Fat Body    2.4 Larval Salivary Gland    1 Larval Trachea    5.475 Larval Carcass no informative data Adult Head    58.3 Adult Eye    115.175 Adult Brain    83.1 Adult Thoracic-Abdominal Ganglion    112.9 Adult Crop    6.6 Adult Midgut    2.9 Adult Hindgut    6.4 Adult Malpighian Tubules    4.2 Adult Fat Body    9.3 Adult Salivary Gland no informative data Adult Heart    2.125 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    0.9 Adult Testis    3.7 Adult Male Accessory Gland    8.7 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    98.525 Larval Midgut    4.4 Larval Hindgut    3.6 Larval Malpighian Tubules    2.8 Larval Fat Body    2.4 Larval Salivary Gland    1 Larval Trachea    5.475 Larval Carcass no informative data Adult Head    58.3 Adult Eye    115.175 Adult Brain    83.1 Adult Thoracic-Abdominal Ganglion    112.9 Adult Crop    6.6 Adult Midgut    2.9 Adult Hindgut    6.4 Adult Malpighian Tubules    4.2 Adult Fat Body    9.3 Adult Salivary Gland no informative data Adult Heart    2.125 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    0.9 Adult Testis    3.7 Adult Male Accessory Gland    8.7 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass no informative data Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    58.3   NA  Eye    115.175   NA  Brain    83.1   98.525  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    112.9   NA  Crop    6.6   4.4  Midgut    2.9   3.6  Hindgut    6.4   2.8  Malpighian Tubules    4.2   2.4  Fat Body    9.3   1  Salivary Gland    no informative data   NA  Heart    2.125   5.475  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    0.9   NA  Testis    3.7   NA  Male Accessory Gland    8.7   no informative data  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_31
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003430 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG16738-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for slp1 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal (with slp11) slp1A10 lethal (with slp13) slp1A10 lethal (with slp1A10) slp11 slp13 lethal | embryonic stage slp11 slp13 slp1A509 slp1Δ34B slp1Δ41E slp1Δ46G lethal | embryonic stage | recessive slp1unspecified slp1Δ46G lethal | recessive slp105965 viable, with Scer\GAL4pnr-MD237 slp1GD4388 Other Phenotypes Allele body color defective, with Scer\GAL4pnr-MD237 slp1GD4388 visible, with Scer\GAL4pnr-MD237 slp1GD4388 Phenotype manifest in Allele abdominal 2 ventral denticle belt | embryonic stage slp1hs.PC abdominal 4 ventral denticle belt | embryonic stage slp1hs.PC abdominal 6 ventral denticle belt | embryonic stage slp1hs.PC abdominal 8 ventral denticle belt | embryonic stage slp1hs.PC abdominal segment 1 slp1Δ34B abdominal segment 2 slp1Δ34B abdominal segment 3 slp1Δ34B abdominal segment 4 slp1Δ34B cuticle slp1Δ34B slp1Δ41E slp1Δ46G slp11 slp13 slp1A509 denticle belt slp1Δ34B slp1Δ41E slp1Δ46G slp11 slp13 slp1A509 embryonic/first instar larval cuticle & abdominal segment 1 slp1unspecified embryonic/first instar larval cuticle & abdominal segment 3 slp1unspecified embryonic/first instar larval cuticle & abdominal segment 5 slp1unspecified embryonic/first instar larval cuticle & abdominal segment 7 slp1unspecified embryonic/first instar larval cuticle & mesothoracic segment slp1unspecified embryonic/larval dorsal vessel slp105965 embryonic head slp1Δ46G embryonic labial segment slp11 head slp1Δ46G hypostomal sclerite slp1Δ41E slp13 slp1A509 labial segment slp1Δ46G lateral process slp1Δ41E slp13 slp1A509 mandibular segment slp1Δ46G mesothoracic tergum, with Scer\GAL4pnr-MD237 slp1GD4388 neuroblast NB3-5 slp1hs.PC neuroblast NB4-2 | ectopic slp1hs.PC neuroblast NB5-3 slp1hs.PC neuroblast NB5-6 slp1hs.PC RP2 neuron | ectopic slp1hs.PC RP2sib neuron | ectopic slp1hs.PC trichogen cell, with Scer\GAL4pnr-MD237 slp1GD4388 ventral arm of lacinia slp1Δ41E slp13 slp1A509 visceral mesoderm, with Scer\GAL4how-24B, Scer\GAL4twi.PG slp1Scer\UAS.cSa
Classical Alleles ( 10 )
For All Classical Alleles Show
Allele of slp1 Class Mutagen Stocks Known lesion slp11 hypomorphic allele - genetic evidence ethyl methanesulfonate 9 -- slp12 amorphic allele - genetic evidence ethyl methanesulfonate 1 -- slp105965 P-element activity 1 -- slp13 hypomorphic allele - genetic evidence ethyl methanesulfonate 1 -- slp1Δ34B amorphic allele - genetic evidence Delta2-3 0 Yes slp1Δ46G amorphic allele - genetic evidence Delta2-3 0 Yes slp1A10 gamma ray 0 -- slp1A509 hypomorphic allele - genetic evidence P-element activity 0 -- slp1unspecified 0 -- slp1Δ41E hypomorphic allele - genetic evidence Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 12 )
For All Alleles Carried on Transgenic Constructs Show
Allele of slp1 Class Mutagen Stocks Known lesion slp1GD4388 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes slp1HMS01107 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes slp1JF02517 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes slp1KK106295 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes slp1hs.PC in vitro construct - regulatory fusion 0 Yes slp1Scer\FRT.Rnor\CD2.Scer\UAS in vitro construct - regulatory fusion 0 Yes slp1Scer\FRT.sna in vitro construct - regulatory fusion 0 Yes slp1Scer\UAS.cRa in vitro construct - regulatory fusion 0 Yes slp1Scer\UAS.cSa FLPase 0 Yes slp1sna.PA FLPase 0 Yes slp1ΔEH1.Scer\FRT.sna in vitro construct - site directed mutagenesis 0 Yes slp1ΔEH1.sna FLPase 0 --
Aneuploid Aberrations
Duplicated in	Dp(2;3)odd5.1
Disrupted in	Df(2L)ed1 (Spradling et al., 1999, Jaynes and Fujioka, 2004, Tearle and Nusslein-Volhard, 1987, Grossniklaus et al., 1992, de Belle et al., 1993, BDGP Project Members, 1994-1999, Cadigan et al., 1994, Cadigan et al., 1994, Harbecke and Lengyel, 1995) Df(2L)ed-dp (Spradling et al., 1999, de Belle et al., 1993, BDGP Project Members, 1994-1999) Df(2L)Exel6009 (Ryder, 2004.4.26) Df(2L)odd-4.25 (Nusslein-Volhard et al., 1984, Nusslein-Volhard et al., 1985) Df(2L)sc19-8 (de Belle et al., 1993) Df(2L)slp2-Δ66C (Grossniklaus et al., 1992) Df(2L)slpS37A (Sato and Tomlinson, 2007) Df(2L)slp-Δ34B (Cadigan et al., 1994, Cadigan et al., 1994, Riechmann et al., 1997) T(2;3)slp1A10 (de Belle et al., 1993) T(Y;2)D6 (de Belle et al., 1993) Ts(YLt;2Rt)H121 (Muller et al., 1999) Ts(YLt;2Rt)J136 (Muller et al., 1999)
Not disrupted in	Df(2L)M24F11 (de Belle et al., 1993)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4388} NA P{KK106295} NA P{Scer\UAS(FRT.y+CD2)slp1.S} NA P{Scer\UAS(-FRT)slp1.S} NA P{TRiP.HMS01107} NA P{TRiP.JF02517} NA P{UAS-slp1.R} NA heat-shock construct P{HS-slp1} NA reporter construct P{slp1-lacZ.1} No P{slp1-lacZ.2} No P{slp1-lacZ.2m5} No P{slp1-lacZ.2m7} No P{slp1-lacZ.3} No P{slp1-lacZ.4} No P{slp1-lacZ.2000-P} No P{slp1-lacZ.3118-P} No P{slp1-lacZ.3125-att} No P{slp1-lacZ.3125-P} No P{slp1-lacZ.3918-P} No P{slp1-lacZ.3925-P} No P{slp1-lacZ.5534-P} No P{slp1-lacZ.8165-att} No P{slp1-lacZ.8165-P} No P{slp1-lacZ.8171-att} No P{slp1-lacZ.8171-P} No P{slp1-lacZ.8765.3918-P} No P{slp1-lacZ.8765-P} No P{slp1-lacZ.8771-P} No P{slp1-lacZ.A.CRM} No P{slp1-lacZ.B.CRM} No P{slp1-lacZ.C.CRM} No P{slp1-lacZ.DESE} No P{slp1-lacZ.DESE+PESE} No P{slp1-lacZ.PESE.C1+-att} No P{slp1-lacZ.PESE.ΔC1-att} No P{slp1-lacZ.PESE} No characterization construct P{sna(FRT.STOP)slp1.A} NA P{sna(FRT.STOP)slp1.ΔEH1} NA P{sna(-FRT)slp1.A} NA P{sna-slp1.ΔEH1} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lArB}slp1A509 No P{PZ}slp105965 No
Gene Ontology: Function, Process & Cellular Component ( 14 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function
CV term Evidence References
sequence-specific distal enhancer binding RNA polymerase II transcription factor activity inferred from direct assay (Yu et al., 1999)
Biological Process
CV term Evidence References
heart formation inferred from mutant phenotype (Park et al., 1996) negative regulation of transcription from RNA polymerase II promoter inferred from direct assay (Yu et al., 1999) specification of segmental identity, head inferred from expression pattern (Grossniklaus et al., 1994) inferred from genetic interaction with bcd (Grossniklaus et al., 1994) inferred from genetic interaction with dl (Grossniklaus et al., 1994) inferred from genetic interaction with ems (Grossniklaus et al., 1994) inferred from genetic interaction with Kr (Grossniklaus et al., 1994) inferred from genetic interaction with phl (Grossniklaus et al., 1994) inferred from genetic interaction with rl (Grossniklaus et al., 1994) inferred from genetic interaction with tor (Grossniklaus et al., 1994) inferred from genetic interaction with tsl (Grossniklaus et al., 1994) inferred from mutant phenotype (Grossniklaus et al., 1994)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 10 terms )
Molecular Function
CV term Evidence References
sequence-specific DNA binding inferred from electronic annotation with InterPro:IPR001766, InterPro:IPR018122 (FlyBase Curators et al., 2004-) sequence-specific DNA binding transcription factor activity non-traceable author statement (Swiss-Prot Project Members, 1993.7.1)
Biological Process
CV term Evidence References
anterior/posterior axis specification, embryo non-traceable author statement (Taylor, 2002) blastoderm segmentation traceable author statement (Cripps and Olson, 2002) heart development traceable author statement (Cripps and Olson, 2002) mesoderm formation traceable author statement (Cripps and Olson, 2002) regulation of transcription, DNA-dependent inferred from sequence or structural similarity with UniProtKB:Q00939 (FlyBase, 1992-) segment specification non-traceable author statement (Swiss-Prot Project Members, 1993.7.1) specification of segmental identity, mandibular segment non-traceable author statement (Swiss-Prot Project Members, 1993.7.1)
Cellular Component
CV term Evidence References
nucleus inferred from sequence or structural similarity with UniProtKB:Q00939 (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 1993.7.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions slp1 allele Gene References slp1hs.PC gsb (Bhat et al., 2000) wg (Bhat et al., 2000) slp1unspecified l(2)24CDa (de Belle et al., 1993) slp1Δ34B slp2 (Lee and Frasch, 2000) unspecified RpII140 (Parkhurst and Ish-Horowicz, 1991)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 59810 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0003430 DroID - A comprehensive database of gene and protein interactions. • FBgn0003430 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33607
Orthologs
Genome-wide drosophilid orthologs	Dana\GF15038 Dere\GG24971 Dgri\GH11193 Dmoj\GI18113 Dper\GL18682 Dpse\GA14117 Dsec\GM18442 Dsim\GD23260 Dvir\GJ16300 Dwil\GK15483 Dyak\GE18262
Curated drosophilid orthologs	Dpse\GA14117
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • XP_001898607.1 Brugia malayi (roundworm nematode) CN26162 Caenorhabditis brenneri (small nematode) CBP03597 Caenorhabditis briggsae (nematode) CE04965 Caenorhabditis elegans (worm) ENSCAFP00000029503 Canis familiaris (dog) ENSCSAVP00000015949 Ciona savignyi (sedentary tunicate) 182306 Capitella spl (polychaete worm) ENSECAP00000017537 Equus caballus (horse) ENSGACP00000008858 Gymnopilus aculeatus (mushroom) ENSGALP00000015999 Gallus gallus (chicken) 80739 Hypsipyla robusta (cedar shoot borer) XP_001607710.1 Nasonia vitripennis (wasp) ENSORLP00000013442 Oryzias latipes (japanese killifish) Smp_076300 Schistosoma mansoni (trematode parasite) ENSTNIP00000007501 Tetraodon nigroviridis (green spotted pufferfish) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0235690 FBgn0217488 FBgn0203484 FBgn0194648 FBgn0173349 FBgn0140853 FBgn0117100 FBgn0092063
Stocks & Reagents
Stocks Listed in FlyBase ( 16 )
Bloomington	5348 slp11/CyO; P{ftz/lacC}1 5349 slp12/CyO; P{ftz/lacC}1 5350 slp13/CyO; P{ftz/lacC}1 29354 y1 v1; P{TRiP.JF02517}attP2 3135 slp11 b1 eve15H6a/SM6a 11463 P{PZ}slp105965 cn1/CyO; ry506 1685 slp11 ptc7 px1 sp1/SM6a 34633 y1 sc* v1; P{TRiP.HMS01107}attP2 1251 slp11 en58 c1 px1 sp1/SM6a
Kyoto	106451 slp11 ptc7 px1 sp1/SM6a
VDRC	v107562 P{KK106295}VIE-260B v15749 w1118; P{GD4388}v15749
	More stocks available...
Genomic Clones ( 1 )
	BACR06H02 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 12 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH04704
Other clones	DPiM_GH04704
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH04226 RE28344 RE31524
Other clones	EK006017 EK042858 EK044664 EK045364 EK085120 UUGC0415 UUGC0419
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0003430 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33607
Antibody Information
	polyclonal (Cadigan et al., 1994)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	The EH1 gro binding site is required for slp1-mediated repression. (Andrioli et al., 2004) slp1 and slp2 function downstream of wg signaling to generate the NB4-2 cell. (Bhat et al., 2000) wg and slp1/slp2 act in a common pathway in which slp1/slp2 serves as a direct target of wg signals that mediates wg effects in both ectoderm and mesoderm. slp1/slp2 act downstream of wg to repress bap and visceral mesoderm formation. (Lee and Frasch, 2000) Induction of slp1 by wg involves pan binding to multiple binding sites within a wg-responsive enhancer in the 5' region of slp1. wg signalling induces striped expression of slp1/slp2 in the mesoderm, providing striped mesodermal domains competent to respond to subsequent slp1/slp2-independent wg signals that induce somatic muscle and heart progenitors. In wg expressing ectodermal cells, slp1/slp2 is an integral component in an autocrine feedback loop of wg signalling. (Lee and Frasch, 2000) slp1 protein may be a direct repressor of the ftz gene in developing embryos. (Yu et al., 1999) In a sample of 79 genes with multiple introns, 33 showed significant heterogeneity in G+C content among introns of the same gene and significant positive correspondence between the intron and the third codon position G+C content within genes. These results are consistent with selection adding against preferred codons at the start of genes. (Kliman and Eyre-Walker, 1998) slp1 and slp2 control all aspects of differentiation in the slp domain, including segmental repression of bap, maintenance of high levels of twi and hence myogenesis. (Riechmann et al., 1997) One of the major targets of slp1 action is the wg gene. (Cadigan et al., 1994) slp1 is an activator of wg and a repressor of en and through these activities the distribution of slp1 defines en-competent cells (lacking slp1 protein) and wg-competent cells (containing slp1 protein). The localised expression of slp1 is required to maintain the proper anterior border of the en stripes and restrict wg expression to one side of the en/hh domain. (Cadigan et al., 1994) slp1 plays a predominent role in head formation while slp2 is largely dispensible. (Grossniklaus et al., 1994) slp1 and slp2 are regulated by a common enhancer region upstream of slp1. slp1/slp2 act as a head-specific gap gene in addition to the function as a pair-rule and segment polarity gene in the trunk. (Grossniklaus et al., 1994) Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5. (Clark et al., 1993) One copy of slp2 is sufficient to ensure proper segmentation of the even numbered abdominal segments in a slp1- background. slp1 and slp2 are not equivalent as only one copy of each is required for viability. (Grossniklaus et al., 1992) slp1/slp2 function is required to set up expression of ac in row B of the embryonic proneural cluster. (Hacker et al., 1992) Mutations in zygotic pair rule gene slp1 do not interact with RpII140wimp. (Parkhurst and Ish-Horowicz, 1991)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057382 RefSeq (Proteins) • NP_476730 DDBJ / EMBL / GenBank • AAF51058 AAK77268 AC004781 AC005732 AC010694 AC092240 AI064327 AI401964 AQ025644 AY047536 CAA46889 CAA46890 X66095 X66096 Entrez Gene - A searchable database of RefSeq genes. • 33607 UniProtKB/Swiss-Prot • P32030 UniProtKB/TrEMBL • Q961V5
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Transcription factor, fork head, conserved site (IPR018122) Transcription factor, fork head (IPR001766) Winged helix-turn-helix transcription repressor DNA-binding (IPR011991)
Linkouts
	BioGRID - A database of protein and genetic interactions • 59810 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0003430 DroID - A comprehensive database of gene and protein interactions. • FBgn0003430 DRSC - Results from RNAi screens. • FBgn0003430 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003430 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG16738-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0003430 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33607 InParanoid A subset of ortholog calls from InParanoid. • XP_001898607.1 Brugia malayi (roundworm nematode) CN26162 Caenorhabditis brenneri (small nematode) CBP03597 Caenorhabditis briggsae (nematode) CE04965 Caenorhabditis elegans (worm) ENSCAFP00000029503 Canis familiaris (dog) ENSCSAVP00000015949 Ciona savignyi (sedentary tunicate) 182306 Capitella spl (polychaete worm) ENSECAP00000017537 Equus caballus (horse) ENSGACP00000008858 Gymnopilus aculeatus (mushroom) ENSGALP00000015999 Gallus gallus (chicken) 80739 Hypsipyla robusta (cedar shoot borer) XP_001607710.1 Nasonia vitripennis (wasp) ENSORLP00000013442 Oryzias latipes (japanese killifish) Smp_076300 Schistosoma mansoni (trematode parasite) ENSTNIP00000007501 Tetraodon nigroviridis (green spotted pufferfish) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /segment/slopyprd.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33607 modMine - Data generated by the modENCODE project. • FBgn0003430 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0235690 FBgn0217488 FBgn0203484 FBgn0194648 FBgn0173349 FBgn0140853 FBgn0117100 FBgn0092063 REDfly - A database of transcriptional regulatory elements. • FBgn0003430
Synonyms & Secondary IDs ( 24 )
Reported As
Symbol Synonym	CG16738 (Gonzalez-Aguero et al., 2005, Keleman et al., 2009.8.5, Perkins et al., 2009, Ni et al., 2010.12.1) Dmslp1 (Mazet et al., 2003) FD6 (Kaufmann and Knoechel, 1996, Hacker et al., 1992) FoxG (Mazet et al., 2006) l(2)05965   sko1 (Weber et al., 2009) slp (Kozlov et al., 2009, Ochoa-Espinosa et al., 2005, Buescher et al., 2004, Furlong, 2004, Jaynes and Fujioka, 2004, Ingolia, 2004, Sanchez and Thieffry, 2003, Albert and Othmer, 2003, Thieffry and Sanchez, 2003, Galis et al., 2002, Kobayashi et al., 2003, Vander Zwan and Gergen, 2003, Fujioka et al., 2002, Cripps and Olson, 2002, Walrad et al., 2002, Lee et al., 2001, Kobayashi et al., 2001, Myasnikova et al., 2001, Kobayashi et al., 2001, Lee and Frasch, 2000, Rusch and Kaufman, 2000, Piepenburg et al., 2000, Nasiadka et al., 2000, Schuldt, 2000, Lee and Frasch, 2000, Jack and Myette, 1999, Frasch, 1999, Wilson, 1999, Paululat et al., 1999, Muller et al., 1999, Kobayashi et al., 1999, Bowler et al., 1999, Saulier-Le Drean et al., 1998, Kosman et al., 1998, Baylies et al., 1998, Ruiz-Gomez, 1998, Struhl et al., 1997, Miskiewicz et al., 1996, Park et al., 1996, Ma et al., 1996, Goriely et al., 1996, Fujioka et al., 1995, Harbecke and Lengyel, 1995, Fietz et al., 1994, Martinez Arias, 1993, Pankratz and Jaeckle, 1993, Kornberg and Tabata, 1993, de Belle et al., 1993, Jackle and Sauer, 1993, Topol et al., 1991, Bellen et al., 1989, Jack et al., 1988, Coulter and Wieschaus, 1988, Frasch and Levine, 1987, DiNardo and O'Farrell, 1987, Tearle and Nusslein-Volhard, 1987, Sato and Tomlinson, 2007, Sandmann et al., 2007, Myasnikova et al., 2009, Rakovitsky et al., 2007, Goldstein et al., 2005, Gebelein and Mann, 2007, Surkova et al., 2008, Larsen et al., 2008, Lindner et al., 2007, Pisarev et al., 2009, Schaaf et al., 2009, Surkova et al., 2008, Blanco and Gehring, 2008) Slp (Lee and Frasch, 2005, Taylor, 2002, Sato and Tomlinson, 2007, Noyes et al., 2008) Slp1 (Merabet, 2005, The modENCODE Consortium, 2010, The modENCODE Consortium, 2010) Slp-1 (Lin et al., 2003) slp-1 (Cripps and Olson, 2002, Urbach et al., 2006) slp1 (Wang and Gergen, 2007, Sato and Tomlinson, 2007, Halfon and Arnosti, 2007, Stuart et al., 2007, Gergen et al., 2008, Wang et al., 2007, Lee and Frasch, 2004, Jakobsen et al., 2007, Vanderzwan-Butler et al., 2007, Hare et al., 2008, Fowlkes et al., 2008, Nekrasov et al., 2007, Sandmann et al., 2006, Choksi et al., 2006, Liu et al., 2009, Ochoa-Espinosa et al., 2009, Walrad et al., 2010, Luengo Hendriks et al., 2006, Grad et al., 2004, Gutierrez-Aviño et al., 2009, Neely et al., 2010, Sen et al., 2010, Gurunathan et al., 2004, Wang et al., 2010, Prazak et al., 2010, Walrad et al., 2011, Pruteanu-Malinici et al., 2011) SLP1 (MacArthur et al., 2009) slp-2 (Cripps and Olson, 2002)
Name Synonym	Sloppy (Wheeler et al., 2006) sloppy pair (Gutierrez-Aviño et al., 2009) sloppy-paired (Anonymous, 2004, Papatsenko and Small, 2004, Walrad et al., 2004, Alexandre and Vincent, 2002, Schwartz and Pirrotta, 2007, Papatsenko et al., 2006, Myasnikova et al., 2009, Gebelein and Mann, 2007, Pisarev et al., 2009, Surkova et al., 2008, Zamparo and Perkins, 2009) sloppy paired (Rakovitsky et al., 2007, Goldstein et al., 2005, Vanderzwan-Butler et al., 2007, Lindner et al., 2007, Blanco and Gehring, 2008) Sloppy-paired (Sato and Tomlinson, 2007, Sato and Tomlinson, 2007) sloppy-paired 1 (Andrioli and Small, 2002, Chang et al., 2008, Ochoa-Espinosa et al., 2009) sloppy paired 1 (Grossniklaus, 1992.5.20, Wheeler et al., 2006, Nekrasov et al., 2007, Sen et al., 2010, Acharya et al., 2010) sloppy-paired-1 (Wang and Gergen, 2007, Wang et al., 2007, Walrad et al., 2010, Wang et al., 2010, Prazak et al., 2010) Sloppy-paired 1 (Hare et al., 2008) Sloppy paired 1 (MacArthur et al., 2009)
Secondary FlyBase IDs
	FBgn0010610
References ( 205 )
Generate a list of	All references relating to this gene ( 205 )
List References by type	Research paper  ( 123 ) Supplementary material  ( 6 ) Review  ( 27 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 29 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Stock list  ( 1 ) Conference report  ( 1 ) Computer file  ( 2 ) Protein sequence record  ( 1 ) Book  ( 1 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 8 )
	Pruteanu-Malinici et al., 2011, PLoS Comput. Biol. 7(7): e1002098 Automatic Annotation of Spatial Expression Patterns via Sparse Bayesian Factor Models. [FBrf0214618] Walrad et al., 2011, Mol. Biol. Cell 22(8): 1364--1374 Hairless is a cofactor for Runt-dependent transcriptional regulation. [FBrf0213441] Acharya et al., 2010, Mol. Biol. Cell 21(22): 3890--3901 Paradoxical Instability-Activity Relationship Defines a Novel Regulatory Pathway for Retinoblastoma Proteins. [FBrf0212298] Neely et al., 2010, Cell 141(1): 142--153 A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. [FBrf0210524] Prazak et al., 2010, Dev. Biol. 344(2): 1048--1059 Non-additive interactions involving two distinct elements mediate sloppy-paired regulation by pair-rule transcription factors. [FBrf0211418] Sen et al., 2010, Dev. Biol. 343(1-2): 167--177 Odd paired transcriptional activation of decapentaplegic in the Drosophila eye/antennal disc is cell autonomous but indirect. [FBrf0211003] Walrad et al., 2010, Mol. Biol. Cell 21(13): 2315--2326 Distinct contributions of conserved modules to runt transcription factor activity. [FBrf0211193] Wang et al., 2010, PLoS ONE 5(7): e11498 NELF Potentiates Gene Transcription in the Drosophila Embryo. [FBrf0211281] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...