Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\slrp using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\slrp in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Mutations of slrp cause abnormalities in the electroretinogram (ERG) and/or prolonged depolarization after potential (PDA).
In electroretinogram recordings, there is an abnormally slow return of photoreceptor potential to baseline after stimulus is turned off; also, reduced light-on and light-off transient spikes; these phenotypes reported for the first three alleles isolated (Pak, 1975); action spectrum of mutant ERG (Pak, 1975) same as in wild-type; hence, opsins unlikely to be altered. Intracellular recordings reveal some penetrated photoreceptors to have potentials with abnormally slow decay and others to show normal receptor potentials (Pak, 1975). slrp mutants are generally hypoactive (Homyk, Pye and Pak, 1981) and show ether-induced leg shaking, cold-induced leg paralysis and the defects in ERG; slrp4 exhibits, in its permissive temperature range (20oC-30oC), the phenotypes just listed; in addition it is difficult to arouse for flight, has abnormally short jumps elicited, and, as a male, shows abnormal courtship wing displays (Homyk and Sheppard, 1977); in the temperature range noted above, this allele causes ERG phenotypes like those associated with the original mutations (slow rate of repolarization, transient amplitude deficits); as the temperature is lowered from 20oC to 15oC, slrp4 becomes (<17oC) sensitive to mechanical stress (Homyk and Sheppard, 1977), and eventually completely paralyzed (Homyk and Pye, 1989); the ERG abnormalities are accentuated at these low temperatures (Homyk and Pye, 1989); for example, the off-transient spike can be completely eliminated in 15oC recordings; this effect is reversed on raising the temperature (Homyk and Pye, 1989).