FlyBase Gene Report: Dmel\sm

General Information

Symbol

Dmel\sm

Species

D. melanogaster

Name

smooth

Annotation Symbol

CG9218

Feature Type

protein_coding_gene

FlyBase ID

FBgn0003435

Gene Model Status

Current

Stock Availability

66 publicly available

Gene Summary

smooth (sm) encodes an RNA binding, heterogeneous nuclear ribonucleoprotein involved in axon guidance, mRNA processing, chemosensation, determination of lifespan and feeding behavior. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Red Book
Interactive Fly

Also Known As

smo, l(2)05338

Key Links

Genomic Location

Cytogenetic map

56D15-56E1

Sequence location

2R:19,517,864..19,631,508 [-]

Recombination map

2-90

RefSeq locus

NT_033778 REGION:19517864..19631508

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (9 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables mRNA binding

inferred from biological aspect of ancestor with PANTHER:PTN002538397

(GO Reference Genome Project, 2011-)

inferred from sequence or structural similarity

(Lasko, 2000)

enables RNA binding

inferred from electronic annotation with InterPro:IPR000504, InterPro:IPR006536

(InterPro Project Members, 2004-)

Biological Process (5 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in adult feeding behavior

inferred from mutant phenotype

(Layalle et al., 2005)

involved_in axon guidance

inferred from mutant phenotype

(Layalle et al., 2005)

involved_in determination of adult lifespan

inferred from mutant phenotype

(Paik et al., 2012)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in mRNA processing

inferred from electronic annotation with InterPro:IPR006536

(InterPro Project Members, 2004-)

involved_in regulation of RNA splicing

inferred from biological aspect of ancestor with PANTHER:PTN002538397

(GO Reference Genome Project, 2011-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in nucleoplasm

inferred from high throughput direct assay

(Lye et al., 2014)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN002538397

(GO Reference Genome Project, 2011-)

located_in nucleus

inferred from electronic annotation with InterPro:IPR006536

(InterPro Project Members, 2004-)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

sm: smooth

Abdomen partially denuded of bristles and shrunken. Wings usually warped and semierect. Acrostichal hairs disarranged. Tendency for erect postscutellars. Male genitalia often disturbed. Anal protuberance of female bent down. Viability 30% wild type. Both sexes entirely sterile. RK2.

sm2

Reduced numbers of abdominal bristles; alteration of abdominal bristle pattern and a reversal of the sexual dimorphism for abdominal bristle number. Temperature sensitive with a TSP in the pupal period. Both sexes fertile.

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\sm for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry A0A0B4K7I2)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.42

Gene model reviewed during 5.40

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 5.46

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

sm-RA

FBtr0086492

NM_057383

2995

475

sm-RAA

FBtr0308797

NM_001259505

15139

508

sm-RAB

FBtr0310331

NM_001274164

14827

509

sm-RAC

FBtr0332857

NM_001274165

1299

301

sm-RB

FBtr0086495

NM_166369

1783

404

sm-RE

FBtr0100232

NM_001032269

2330

475

sm-RG

FBtr0110898

NM_001043096

1230

260

sm-RH

FBtr0301609

NM_001032268

3010

480

sm-RI

FBtr0301610

NM_166370

1831

420

sm-RJ

FBtr0304653

NM_001259495

2379

464

sm-RK

FBtr0304654

NM_001259494

3175

535

sm-RL

FBtr0304655

NM_001259496

3046

492

sm-RM

FBtr0304656

NM_001259497

15106

497

sm-RO

FBtr0308785

NM_001259498

8932

494

sm-RP

FBtr0308786

NM_166368

2872

434

sm-RT

FBtr0308790

NM_001259499

3226

552

sm-RU

FBtr0308791

NM_001259500

15344

515

sm-RV

FBtr0308792

NM_001259501

3190

540

sm-RW

FBtr0308793

NM_001259502

1179

260

sm-RY

FBtr0308795

NM_001259503

1251

260

sm-RZ

FBtr0308796

NM_001259504

2378

491

Additional Transcript Data and Comments

Reported size (kB)

2.6 (longest cDNA)

(zur Lage et al., 1997)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

sm-PA

FBpp0085681

51.9

475

8.79

FBpp0300954

55.5

508

8.62

FBpp0302014

55.8

509

8.28

FBpp0305079

32.8

301

8.61

FBpp0085684

44.0

404

9.67

FBpp0099612

51.9

475

8.79

FBpp0110198

28.5

260

9.18

FBpp0290824

52.4

480

8.95

FBpp0290825

45.7

420

9.66

FBpp0293195

51.1

464

9.83

FBpp0293196

59.1

535

9.09

FBpp0293197

53.8

492

8.78

FBpp0293198

54.3

497

8.62

FBpp0300942

54.0

494

8.46

FBpp0300943

47.0

434

8.46

FBpp0300947

61.0

552

9.08

FBpp0300948

56.4

515

8.77

FBpp0300949

59.6

540

8.95

FBpp0300950

28.5

260

9.18

FBpp0300952

28.5

260

9.18

FBpp0300953

53.7

491

8.79

A0A0B4K7I6

NP_001246433

AFH08186

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

475 aa isoforms: sm-PA, sm-PE

260 aa isoforms: sm-PG, sm-PW, sm-PY

Additional Polypeptide Data and Comments

Reported size (kDa)

475 (aa); 51.9 (kD predicted)

(zur Lage et al., 1997)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\sm using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

2.32

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

larval nervous system

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in nucleoplasm

inferred from high throughput direct assay

(Lye et al., 2014)

Expression Deduced from Reporters

Reporter: PBac{754.P.FSVS-0}sm^CPTI002828

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain cell body rind

(Knowles-Barley, 2011.8.24)

spermatogenesis

primary spermatocyte

(Lowe et al., 2014)

Y chromosome loop

(Lowe et al., 2014)

Reporter: PBac{768.FSVS-0}sm^CPTI002712

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain cell body rind

(Knowles-Barley, 2011.8.24)

Reporter: PBac{769.FSVS-1}sm^CPTI002653

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain cell body rind

(Knowles-Barley, 2011.8.24)

spermatogenesis

primary spermatocyte

(Lowe et al., 2014)

Y chromosome loop

(Lowe et al., 2014)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\sm in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\sm

View exonic expression by tissue for Dmel\sm

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0003435

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

37254/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0003435

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0003435

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0003435

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG9218

Flygut - An atlas of the Drosophila adult midgut

FBgn0003435

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\sm

Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 34 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 6 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of sm

Transgenic constructs containing regulatory region of sm

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

Df(2R)BSC820

(Christensen et al., 2009.6.15)

Df(2R)BSC828

(Christensen et al., 2009.7.22)

Inferred from location ( 3 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

sm^MI04033

lethal | recessive

sm⁰⁵³³⁸

partially lethal - majority die

sm⁰⁵³³⁸

partially lethal - majority die, with Scer\GAL4^pnr-MD237

sm^GD12545

partially lethal - majority die | recessive

sm³

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

sm^GD12545

viable, with Scer\GAL4^tin.CΔ4

sm^GD12545

Sterility

Allele

female sterile | recessive

sm³

fertile

male sterile | recessive

sm³

Other Phenotypes

Allele

abnormal feeding behavior

sm⁰⁵³³⁸

abnormal locomotor behavior | adult stage, with Scer\GAL4^elav.PU

abnormal neuroanatomy

sm⁰⁵³³⁸

flightless, with Scer\GAL4^Mef2.PR

sm^GD12545

long lived, with Scer\GAL4^da.Switch.PT

sm^GX21702-1

short lived

sm⁰⁵³³⁸

short lived | heat sensitive, with Scer\GAL4^tin.CΔ4

sm^GD12545

some die during pupal stage, with Scer\GAL4^pnr-MD237

sm^GD12545

visible

sm⁰⁵³³⁸

visible, with Scer\GAL4^pnr-MD237

sm^GD12545

Phenotype manifest in

Allele

abdominal sternite bristle

sm⁰⁵³³⁸

acrostichal bristle

chemosensory neuron & tibia

sm⁰⁵³³⁸

macrochaeta

sm^BG00756

macrochaeta & adult abdomen | ventral

macrochaeta | dorsal

microchaeta

myofibril, with Scer\GAL4^Mef2.PR

sm^GD12545

sarcomere, with Scer\GAL4^Mef2.PR

sm^GD12545

scutellar bristle

trichogen cell, with Scer\GAL4^pnr-MD237

sm^GD12545

Z disc, with Scer\GAL4^Mef2.PR

sm^GD12545

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (16)

Hsap\HNRNPL

12 of 14

Yes

Hsap\HNRNPLL

12 of 14

Yes

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (13)

Rnor\Hnrnpl

13 of 14

Yes

Rnor\Hnrnpll

12 of 14

Yes

Rnor\Fblim1

9 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (14)

Mmus\Hnrnpl

13 of 14

Yes

Mmus\Hnrnpll

11 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (12)

Xtro\hnrnpl

10 of 13

Yes

Xtro\hnrnpll

8 of 13

Yes

2 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (12)

Drer\hnrnpl

13 of 14

Yes

Drer\hnrnpl2

12 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\rbm4.3

1 of 14

Drer\rbm20

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (7)

Cele\hrpl-1

11 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (11)

Agam\AgaP_AGAP012054

9 of 12

Yes

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (27)

Atha\PTB3

3 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:sm. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (8)

heph

3 of 13

CG18823

1 of 13

elav

1 of 13

hfp

1 of 13

Rox8

1 of 13

snf

1 of 13

Sxl

1 of 13

trv

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 3 )

Allele

Disease

Interaction

References

sm¹

ameliorates autosomal recessive intellectual developmental disorder

modeled by Nab2^EP3716

(Rounds et al., 2022)

sm^EY07191

exacerbates tauopathy

modeled by Hsap\MAPT^GMR.Ex.PJ

(Ambegaokar and Jackson, 2011)

sm^GD12545

ameliorates amyotrophic lateral sclerosis type 8

modeled by Vap33^{P58S.UAS.Tag:FLAG}

(Sanhueza et al., 2015)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

HNRNPL; heterogeneous nuclear ribonucleoprotein L

12 of 14

603083

HNRNPLL; heterogeneous nuclear ribonucleoprotein L like

12 of 14

611208

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

sm - Awh

two hybrid

(Hu et al., 2017.6.13)

sm - CG14074

two hybrid

(Hu et al., 2017.6.13)

sm - CG32846

two hybrid

(Hu et al., 2017.6.13)

sm - Lim1

two hybrid

(Hu et al., 2017.6.13)

sm - PAN3

two hybrid, anti tag coimmunoprecipitation, anti tag western blot

(Tang et al., 2023, Hu et al., 2017.6.13)

sm - Traf-like

two hybrid

(Hu et al., 2017.6.13)

sm - lwr

two hybrid

(Hu et al., 2017.6.13)

sm - ps

two hybrid

(Hu et al., 2017.6.13)

sm - sina

two hybrid

(Hu et al., 2017.6.13)

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

TBPH

(Appocher et al., 2017)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Kankel et al., 2007)

Nab2

suppressible

(Rounds et al., 2022)

TBPH

suppressible

(Appocher et al., 2017)

TBPH

enhanceable

(Appocher et al., 2017)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

62912

DroID - A comprehensive database of gene and protein interactions.

FBgn0003435

MIST (protein-protein) - An integrated Molecular Interaction Database

37254

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

gene_with_edited_transcript

(Rodriguez et al., 2012)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-90

Cytogenetic map

56D15-56E1

Sequence location

2R:19,517,864..19,631,508 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

56D15-56E1

Limits computationally determined from genome sequence between P{EP}CG11007^EP736 and P{PZ}sm⁰⁵³³⁸&P{PZ}emm¹

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

56E1-56E2

(determined by in situ hybridisation)

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

56E-56E

(determined by in situ hybridisation)

(zur Lage et al., 1997)

Experimentally Determined Recombination Data

Location

2-90

(FlyBase, 2016)

2-95.0

(Comeron et al., 2012)

2-91.4

(zur Lage et al., 1997)

2-91.5

Left of (cM)

Right of (cM)

mei-W68

(McKim, 1998.3.10)

Notes

Stocks and Reagents

Stocks (66)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

4010

sm^BS

FlyORF

F000792

M{UAS-sm.ORF.3xHA}ZH-86Fb

Korea

12372

P{VT019345-GAL4}attP2

13428

P{VT019303-GAL4}attP2

13429

P{VT019306-GAL4}attP2

13430

P{VT019307-GAL4}attP2

15097

P{VT019309-GAL4}attP2

15098

P{VT019317-GAL4}attP2

15371

P{VT019351-GAL4}attP2

15393

P{VT019298-GAL4}attP2

9218R-1

v108351

More stocks available...

Genomic Clones (70)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (50)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0003435

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0003435

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

sm is required for the normal projection of the chemosensory axons in the leg.

(Layalle et al., 2005)

Mutants do not exhibit defects in the denticle belt of hairs of the larvae.

(Dickinson and Thatcher, 1997)

The genomic organisation of the sm locus has been determined.

(zur Lage et al., 1997)

In embryos homozygous for sm, en expression fades towards the end of the extended germband phase suggesting that sm is important in maintaining en after its initial activation. At the semi-permissive temperatures cold sensitive alleles of sm can suppress the cuticular phenotype of ptc.

(Blader et al., 1991)

Relationship to Other Genes

Source for database merge of

Source for merge of: sm BcDNA:GH10856

(FlyBase, 1996-)

Additional comments

Source for merge of sm BcDNA:GH10856 was a shared cDNA ( date:030728 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: sm CG9218

(Milshina, 1999.11)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

BcDNA:GH10856

CG9218

(Appocher et al., 2017, Hosono et al., 2015, Schertel et al., 2013, Draper et al., 2009, Keleman et al., 2009.8.5, Perkins et al., 2009, Grieder et al., 2007, Quinones-Coello, 2007, Philipps et al., 2004, Norga et al., 2003)

(Tang et al., 2023, Berry et al., 2022, Jevitt et al., 2020, Appocher et al., 2017, Liu and Jin, 2017)

l(2)05338

(McKim, 1998.3.10)

(Sood et al., 2024, Praschberger et al., 2023, Titlow et al., 2023, Joseph et al., 2022, Karam et al., 2022, Rounds et al., 2022, Saha et al., 2022, Pang et al., 2021, Cho et al., 2020, Park et al., 2020, Ramesh et al., 2020, Chen et al., 2018, Joseph et al., 2018, Hu et al., 2017.6.13, Sen et al., 2017, Clandinin and Owens, 2016-, Fear et al., 2016, Duff et al., 2015, Gene Disruption Project members, 2015-, Khan et al., 2015, Lin et al., 2015, Nagarkar-Jaiswal et al., 2015, Sanhueza et al., 2015, Ashwal-Fluss et al., 2014, Bonke et al., 2013, Schertel et al., 2013, Díaz-Castillo et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Paik et al., 2012, Rodriguez et al., 2012, Smibert et al., 2012, Ambegaokar and Jackson, 2011, Christensen et al., 2009.6.15, Christensen et al., 2009.7.22, Draper et al., 2009, Hazelett et al., 2009, Buszczak et al., 2007, Grieder et al., 2007, Kankel et al., 2007, Quinones-Coello, 2007, Layalle et al., 2005, Liu et al., 2005, Macdonald and Long, 2005, Philipps et al., 2004)

smo

(Blader et al., 1991, Ingham, 1991, Ingham, 1991)

smooth

(Ugrankar et al., 2018)

Name Synonyms

Smooth

(Lowe et al., 2014, Paik et al., 2012, Walker et al., 2011)

smooth

(Ambegaokar and Jackson, 2011, Dalton et al., 2010, Draper et al., 2009, Kankel et al., 2007, Burnette et al., 2005, Burnette et al., 2005, Layalle et al., 2005, Zur Lage, 1996.3.5)

Secondary FlyBase IDs

FBgn0010597
FBgn0063694

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 176 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

37254

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

A0A0B4K7I2

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

A0A0B4K7I2

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0003435

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

37254/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0003435

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0003435

FlyMine - An integrated database for Drosophila genomics

FBgn0003435

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG9218

MARRVEL_MODEL - MARRVEL (model organism gene)

37254

Linkouts

BioGRID - A database of protein and genetic interactions.

62912

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0003435

DroID - A comprehensive database of gene and protein interactions.

FBgn0003435

DRSC - Results frm RNAi screens

FBgn0003435

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0003435

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0003435

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG9218

Flygut - An atlas of the Drosophila adult midgut

FBgn0003435

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC002855

MIST (protein-protein) - An integrated Molecular Interaction Database

37254

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (137)

The following external sites may use different assemblies or annotations than FlyBase.

2.32

Report Sections