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General Information
Symbol
Dmel\snf
Species
D. melanogaster
Name
sans fille
Annotation Symbol
CG4528
Feature Type
FlyBase ID
FBgn0003449
Gene Model Status
Stock Availability
Gene Snapshot
sans fille (snf) encodes a protein component of U1 and U2 small nuclear ribonucleoproteins (snRNPs). U1 and U2 snRNPs combine with other snRNPs on the pre-mRNA to assemble a spliceosome. It contributes to alternative splicing regulation. [Date last reviewed: 2019-03-14]
Also Known As
fs(1)1621, fs(1)A1621, liz, SNF/D25, splicing necessary factor
Key Links
Genomic Location
Cytogenetic map
Sequence location
X:5,309,242..5,310,501 [+]
Recombination map
1-11
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Protein Family (UniProt)
Belongs to the RRM U1 A/B'' family. (P43332)
Summaries
Gene Group (FlyBase)
U1 SMALL NUCLEAR RIBONUCLEOPROTEIN PARTICLE -
The U1 small nuclear ribonucleoprotein particle (U1 snRNP) contains U1 snRNA and initiates spliceosome assembly by binding to the 5' splice site in pre-mRNA. (Adapted from PMID:11206553 and PMID:21441581).
U2 SMALL NUCLEAR RIBONUCLEOPROTEIN PARTICLE -
The U2 small nuclear ribonucleoprotein particle (U2 snRNP) contains U2 snRNA. It is recruited to the spliceosome after U1 snRNP and forms a stable interaction with the branch site and 3' splice site in pre-mRNA. (Adapted from PMID:23829528 and PMID:21441581).
SPLICEOSOME COMPLEX A -
Nuclear pre-mRNA splicing is catalyzed by the spliceosome which assembles in a step-wise manner. Complex A, the pre-spliceosome, is composed of U1 and U2 snRNPs and proteins involved in recognition of the 5' splice site and branch point. (Adapted from PMID:24452469 and PMID:23118483).
SPLICEOSOME COMPLEX B -
Nuclear pre-mRNA splicing is catalyzed by the spliceosome which assembles in a step-wise manner. After the assembly of complex A on pre-mRNA, the U4-U6 and U5 snRNPs are recruited as a preassembled tri-snRNP to form complex B. U5 snRNP binds exons at the 5' site. (Adapted from PMID:24452469 and PMID:23118483).
Protein Function (UniProtKB)
Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP (By similarity). Plays a role in regulating sex-lethal splicing.
(UniProt, P43332)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
fs(1)A1621
Homozygous females viable but semisterile; males normal. Young females produce ova which can be fertilized and develop normally into adults. Older females cease production of oocytes, producing at first only pseudo nurse cells and subsequently tumorous germaria containing hundreds or thousands of cells of apparently germinal origin. Tumorogenesis takes place earlier at higher temperatures. fs(1)A1621/Df(1)C159 hemizygous for mutant; more temperature sensitive; the germ-line phenotype more severe than in homozygote but viability seems unaffected (Gollin and King). Mosaic studies suggest that gene function is germ line autonomous (Wieschaus et al.; Perrimon and Gans); however, the leakiness of the mutant phenotype introduced an element of ambiguity, raising the possibility of a somatic contribution to oogenesis as well. Interactions with Sxl alleles studied by Cline (1989), Steinmann-Zwicky (1988), and Oliver et al. (1988). Fertility of fs(1)A1621 homozygotes is rescued by the presence of SxlM1. Trans heterozygotes of fs(1)A1621 or Df(1)HC244 with Sxlf1 show very low viability when fs(1)A1621 is inherited from the female; survivors are sterile and show patchy transformations to maleness, such as sex-comb bristles and pigmentation of tergites 5 and 6. Viability of heterozygotes produced by the reciprocal cross also reduced but less so; surviving heterozygotes display reduced fertility. Viability effects appear to arise mostly from a maternal effect of the gene, whereas masculinizing and sterility effects result from decreased zygotic expression. The maternal effect of fs(1)A1621 also reduces survival of Sxlf1/+ daughters; survival is cold sensitive. The presense of SxlM1 rescues fs(1)A1621/Sxlf1 females; Df(1)HC244, SxlM1/Sxlf1 are viable and fertile without male transformations. SxlM1 is also able to rescue Sxlf1/+ from the maternal effect of fs(1)A1621/+, and fs(1)A1621 is able to rescue male viability and fertility of SxlM1 in fs(1)A1621 SxlM1 double mutants. In contrast to the sis genes, which also interact with Sxl, the zygotic dose of fs(1)A1621 has little or no influence on the sexual phenotype of 2X;3A animals; moreover, fs(1)A1621 interacts little if at all with sis-a. Thus although fs(1)A1621+ clearly has a positive involvement in Sxl+ functions, its precise placement in the sex determination hierarchy is currently unclear. It has been suggested that it is involved in the positive autoregulatory aspect of Sxl function that maintains female development. Females heterozygous for fs(1)A1621 and either ovoD1, ovoD2, or ovoD3 have ovarian tumors (Oliver, Pauli, and Mahowald, 1990, Genetics 125: 535-50).
Summary (Interactive Fly)
splicing factor - a crucial component of the spliceosome - regulates alternative splicing - a protein component of U1 and U2 small nuclear ribonucleoproteins (snRNPs) - U1 and U2 snRNPs combine with other snRNPs on the pre-mRNA to assemble a spliceosome - involved in Sex-lethal splicing and consequently in sex determination
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\snf or the JBrowse view of Dmel\snf for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.50
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0070748
835
216
Additional Transcript Data and Comments
Reported size (kB)
1.0 (northern blot)
0.806 (longest cDNA)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0070716
24.5
216
10.34
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
216 (aa); 28 (kD)
216 (aa); 25 (kD)
Comments
External Data
Subunit Structure (UniProtKB)
Belongs to the spliceosome where it is associated with snRNP U1. Interacts with the SMN complex.
(UniProt, P43332)
Crossreferences
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\snf using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (24 terms)
Molecular Function (8 terms)
Terms Based on Experimental Evidence (7 terms)
CV Term
Evidence
References
inferred from physical interaction with FLYBASE:snf; FB:FBgn0003449
inferred from direct assay
inferred from physical interaction with FLYBASE:Sxl; FB:FBgn0264270
inferred from physical interaction with FLYBASE:pps; FB:FBgn0082831
inferred from direct assay
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from sequence or structural similarity
inferred from biological aspect of ancestor with PANTHER:PTN000052389
(assigned by GO_Central )
Biological Process (7 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from direct assay
inferred from high throughput mutant phenotype
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
inferred from sequence or structural similarity with SGD:S000000323
inferred from sequence or structural similarity with SGD:S000001448
inferred by curator from GO:0071011,GO:0071013
inferred from sequence or structural similarity with HGNC:11151
inferred from biological aspect of ancestor with PANTHER:PTN000052389
(assigned by GO_Central )
Cellular Component (9 terms)
Terms Based on Experimental Evidence (6 terms)
CV Term
Evidence
References
inferred from high throughput direct assay
inferred from direct assay
inferred from high throughput direct assay
inferred from direct assay
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
inferred by curator from GO:0000381
traceable author statement
inferred from sequence or structural similarity with HGNC:11151
inferred from sequence or structural similarity with HGNC:11151
inferred from biological aspect of ancestor with PANTHER:PTN000052389
(assigned by GO_Central )
inferred from sequence or structural similarity with SGD:S000000323
inferred from sequence or structural similarity with SGD:S000001448
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: maternally deposited

northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
snf transcripts are expressed in both males and females.
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
snf protein is detected in all tissues throughout most of development.
Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from high throughput direct assay
inferred from direct assay
inferred from high throughput direct assay
inferred from direct assay
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\snf in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 8 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 12 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of snf
Transgenic constructs containing regulatory region of snf
Deletions and Duplications ( 32 )
Phenotypes
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
12 of 15
Yes
Yes
10 of 15
Yes
No
 
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
11 of 15
Yes
Yes
10 of 15
Yes
No
1 of 15
No
No
Rattus norvegicus (Norway rat) (2)
10 of 13
Yes
Yes
9 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (3)
8 of 12
Yes
Yes
6 of 12
No
Yes
1 of 12
No
No
Danio rerio (Zebrafish) (3)
11 of 15
Yes
Yes
10 of 15
No
Yes
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (2)
13 of 15
Yes
Yes
12 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (3)
7 of 9
Yes
Yes
7 of 9
Yes
Yes
7 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (4)
8 of 15
Yes
Yes
4 of 15
No
Yes
1 of 15
No
No
1 of 15
No
Yes
Schizosaccharomyces pombe (Fission yeast) (3)
11 of 12
Yes
Yes
5 of 12
No
Yes
1 of 12
No
Yes
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190GZR )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150CNZ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0F43 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0F3P )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0NFU )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (2)
1 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser

    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    RNA-protein
    Physical Interaction
    Assay
    References
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Subunit Structure (UniProtKB)
    Belongs to the spliceosome where it is associated with snRNP U1. Interacts with the SMN complex.
    (UniProt, P43332 )
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Gene Group - Pathway Membership (FlyBase)
    External Data
    Linkouts
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    X
    Recombination map
    1-11
    Cytogenetic map
    Sequence location
    X:5,309,242..5,310,501 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    4F4-4F4
    Limits computationally determined from genome sequence between P{EP}EP425 and P{EP}CG3249EP1400
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Determined by deficiency mapping (details unspecified).
    Experimentally Determined Recombination Data
    Location
    1-11.7
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (14)
    Genomic Clones (11)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (25)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
     
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for identity of: snf CG4528
    Source for database merge of
    Additional comments
    Other Comments
    The gene products of U2A and snf are co-immunoprecipitated by antibodies to either protein, demonstrating that like their yeast and human counterparts they heterodimerize in vivo. A mutation in the U2A binding motif of snf reduces the amount of heterodimer formation but does not abolish it completely. The U2A binding motif from snf is only essential for heterodimer formation in the absence of the C-terminal end of the protein. The RNA binding specificity domain of snf is essential for interaction with U2A. The U2A gene product incorporation into U2 snRNP does not depend on dimerization of the U2A and snf gene products.
    The interaction of Sxl protein with snf protein is mediated by the R1 RRM (RNA recognition motif) domain of Sxl.
    An increase in the dose of snf+ can trigger the female Sxl RNA splicing mode in male germ cells and can feminise triploid intersex (2X3A) germ cells.
    Sxl protein is associated with snf protein in vitro and in vivo.
    SNF is a component of both U1 and U2 snRNPs. In vitro SNF binds U1 snRNA on its own and U2 snRNA in the presence of Drosophila nuclear extract or human U2A' protein.
    Zygotic snf function is required for sexual differentiation and a cell vital process during postembryonic development. snf protein cooperates with the female-specific Sxl protein to block utilisation of the male-specific exon of the Sxl pre-mRNA.
    In vitro binding assays demonstrate an RNA-dependent interaction between Sxl and snf proteins, crosslinking experiments demonstrate that this association has significance in vivo.
    Alleles of snf can partially enhance the mutant phenotype of ovoD2/+ heterozygous ovaries.
    ovo, otu, snf and Sxl are not involved in the early events of germline sex determination, but are required later, during metamorphosis or in the adult for oogenesis.
    Tumorous cells produced by snf mutants are capable of female-specific transcription and RNA processing indicating the ovarian cells retain some female identity. It is proposed that mutations do not cause male transformation of the female germ line but instead either cause an ambiguous sexual identity or block specific stages of oogenesis.
    snf is an essential gene and an integral component of the machinery required for splice site recognition.
    Mutants display germline hyperplastic phenotype.
    Double homozygous snf- SxlK1274-1 females are semi-lethal and survivors have tumorous egg chambers.
    Partial germline sex transformation occurs in otu, snf, Sxl and bam ovarian tumors.
    The wild type product of snf plays an important role in establishing female-specific RNA splicing of Sxl.
    Mutations in snf block germline expression of Sxl.
    The genetic hierarchy regulating female germ-line sex determination includes tra, tra2, dsx, fu, otu, ovo, snf and Sxl. otu+, ovo+ and snf+ activities are required for female-specific Sxl+ pre-mRNA splicing within 2X germ-line cells.
    D25 is the Drosophila homologue of U1-A human protein despite its sequence similarity to U2-B human protein.
    The snf locus displays a lethal synergistic interaction with Sxl. snf is a positive regulator of Sxl in the germline and soma.
    An extra wild type copy of snf is not sufficient to rescue the female lethality of hhb.PP.
    Mutations in snf interact with Sxl.
    The interaction between snf and Sxl mutations reduces the viability of females heterozygous for Sxl. The mosaicism exhibited by flies heterozygous for snf and Sxl- suggests that the transformation of diplo-X tissues to male morphology is due to the interaction of snf and Sxl in the zygote.
    Homozygous females have small ovaries filled with undifferentiated germ cells and very rare oocytes with nurse cells. Females of the genotype Df(1)HC244, SxlM1/snf are fully fertile with normal looking ovaries, snf must act upstream of Sxl. Maternal snf gene product is involved in the activation of zygotic snf+ genes.
    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 38 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    Other crossreferences
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
    KEGG Genes - Molecular building blocks of life in the genomic space.
    modMine - A data warehouse for the modENCODE project
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DPiM - Drosophila Protein interaction map
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyMine - An integrated database for Drosophila genomics
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    Synonyms and Secondary IDs (23)
    Reported As
    Symbol Synonym
    D25
    U2 snRNP
    U2 snRNP B'' protein
    fs(1)A16121
    snRNP-U1-A
    Secondary FlyBase IDs
    • FBgn0005667
    Datasets (0)
    Study focus (0)
    Experimental Role
    Project
    Project Type
    Title
    References (206)