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Gene Dmel\snk

General Information
Symbol	Dmel\snk	Species	D. melanogaster
Name	snake	Annotation symbol	CG7996
Feature type	protein_coding_gene	FlyBase ID	FBgn0003450
Gene Model Status	Current	Stock availability	9 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map	3-52.1
Cytogenetic map	87D9-87D9	Sequence location	3R:8,865,887..8,868,492 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene snake is referred to in FlyBase by the symbol Dmel\snk (CG7996, FBgn0003450). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: serine-type endopeptidase activity. There is experimental evidence that it is involved in the biological process: Toll signaling pathway; protein processing. 62 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Disulphide knot CLIP; Peptidase S1/S6, chymotrypsin/Hap; Peptidase S1/S6, chymotrypsin/Hap, active site; Peptidase S1A, chymotrypsin-type; Peptidase cysteine/serine, trypsin-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1624664_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of snk. Gene sequence location is 3R:8865887..8868492.
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	snk: snake Maternal effect lethal. Embryos produced by homozygous mothers show extreme dorsalized phenotype; only dorsally derived cuticle remains, resulting in a hollow tube of dorsal ectoderm. No paternal rescue, even by two doses of snk+; dorsalizes the expression of ftz such that entire ftz stripes in the blastoderm exhibit the wide dorsal conformation and do not narrow ventrally as is normal (Carroll, Winslow, Twombly, and Scott, 1987, Development 99: 327-32). Responds most strongly of all maternal dorsalized mutants to rescue by injection of cytoplasm and poly A+ RNA from wild-type embryos. Injection of wild-type cytoplasm or cytoplasm from other dorsalizing maternal-effect mutants into pre-pole-cell snake embryos fully restores the normal dorsal-ventral pattern, and more than 20% can develop into normal adults; the site of injection appears to be unimportant. Partial rescue also achieved by the injection of poly A+ but not poly A- RNA isolated from cleaving embryos.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Sequence features BKN29589 HFA17060
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 87D9-87D9   Limits computationally determined from genome sequence between P{PZ}CtBP03463 and P{lacW}B52s2249&P{lacW}flflL4179
Experimentally Determined Cytological Location
Cytogenetic map Notes References 87D10-87D12   (determined by in situ hybridisation)   (DeLotto and Spierer, 1986)
Experimentally Determined Recombination Data
Location	3-52.1   3-52 (Tearle and Nusslein-Volhard, 1987)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\snk for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) snk-RA FBtr0082716  NM_079614   1403   435 snk-RB FBtr0112833  NM_001104296   1434   435
Additional Transcript Data & Comments
Reported size (kB)	1.65 (northern blot) (DeLotto and Spierer, 1986)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein snk-PA   FBpp0082184   48.5   435   7.75     NP_524338   AAF54897 snk-PB   FBpp0111746   48.5   435   7.75     NP_001097766   ABW08657
Additional Polypeptide Data & Comments
Reported size (kDa)	430 (aa) (DeLotto and Spierer, 1986)
Comments	The carboxy terminus of snk protein has sequence similarity to serine proteases such as rat preproelastase and trypsinogen. The amino terminus has a short region of amino acid identity with troponin C, and a highly acidic region reminiscent of the calcium binding region of troponin C and calmodulin, suggesting that there may be a calcium-binding site near the amino terminus of snk. (DeLotto and Spierer, 1986)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Peptidase S1/S6, chymotrypsin/Hap, active site (IPR018114) Peptidase S1/S6, chymotrypsin/Hap (IPR001254) Peptidase S1A, chymotrypsin-type (IPR001314) Disulphide knot CLIP (IPR006604) Peptidase cysteine/serine, trypsin-like (IPR009003) MEROPS - An information resource for peptidases and the proteins that inhibit them • S01.200
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF54897   AE014297 ABW08657   BT024420   EC051359   EC051472   EC052313   EC052450   EC053327   EC053787   EC054360   EC054827   EC055020   EC055046   EC055793   EC056341   EC056352   EC056593   X04513 CAA28197
UniProtKB/Swiss-Prot	P05049
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 9     (DeLotto and Spierer, 1986) Comment:reference states 0-4 hr AEL
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0003450    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0003450 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0003450 expression level Developmental Stage   Expression Level embryo 00-02hr    795 embryo 02-04hr    529 embryo 04-06hr    141 embryo 06-08hr    92 embryo 08-10hr    183 embryo 10-12hr    138 embryo 12-14hr    98 embryo 14-16hr    208 embryo 16-18hr    170 embryo 18-20hr    140 embryo 20-22hr    247 embryo 22-24hr    212 larva L1    144 larva L2    89 larva L3 12hr old    174 larva L3 puffstage 1-2    118 larva L3 puffstage 3-6    114 larva L3 puffstage 7-9    161 white prepupae new    165 white prepupae 12hr    108 white prepupae 24hr    69 pupae 2d postWPP    17 pupae 3d postWPP    29 pupae 4d postWPP    16 adult male 01day    4 adult male 05day    5 adult male 30day    10 adult female 01day    365 adult female 05day    582 adult female 30day    543 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (795) embryo 02-04hr  (529) embryo 04-06hr  (141) embryo 06-08hr    92 embryo 08-10hr  (183) embryo 10-12hr  (138) embryo 12-14hr    98 embryo 14-16hr  (208) embryo 16-18hr  (170) embryo 18-20hr  (140) embryo 20-22hr  (247) embryo 22-24hr  (212) larva L1  (144) larva L2    89 larva L3 12hr old  (174) larva L3 puffstage 1-2  (118) larva L3 puffstage 3-6  (114) larva L3 puffstage 7-9  (161) white prepupae new  (165) white prepupae 12hr  (108) white prepupae 24hr    69 pupae 2d postWPP    17 pupae 3d postWPP    29 pupae 4d postWPP    16 adult male 01day    4 adult male 05day    5 adult male 30day    10 adult female 01day  (365) adult female 05day  (582) adult female 30day  (543) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    795 embryo 02-04hr    529 embryo 04-06hr    141 embryo 06-08hr    92 embryo 08-10hr    183 embryo 10-12hr    138 embryo 12-14hr    98 embryo 14-16hr    208 embryo 16-18hr    170 embryo 18-20hr    140 embryo 20-22hr    247 embryo 22-24hr    212 larva L1    144 larva L2    89 larva L3 12hr old    174 larva L3 puffstage 1-2    118 larva L3 puffstage 3-6    114 larva L3 puffstage 7-9    161 white prepupae new    165 white prepupae 12hr    108 white prepupae 24hr    69 pupae 2d postWPP    17 pupae 3d postWPP    29 pupae 4d postWPP    16 adult male 01day    4 adult male 05day    5 adult male 30day    10 adult female 01day    365 adult female 05day    582 adult female 30day    543 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    795 embryo 02-04hr    529 embryo 04-06hr    141 embryo 06-08hr    92 embryo 08-10hr    183 embryo 10-12hr    138 embryo 12-14hr    98 embryo 14-16hr    208 embryo 16-18hr    170 embryo 18-20hr    140 embryo 20-22hr    247 embryo 22-24hr    212 larva L1    144 larva L2    89 larva L3 12hr old    174 larva L3 puffstage 1-2    118 larva L3 puffstage 3-6    114 larva L3 puffstage 7-9    161 white prepupae new    165 white prepupae 12hr    108 white prepupae 24hr    69 pupae 2d postWPP    17 pupae 3d postWPP    29 pupae 4d postWPP    16 adult male 01day    4 adult male 05day    5 adult male 30day    10 adult female 01day    365 adult female 05day    582 adult female 30day    543 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    795 embryo 02-04hr    529 embryo 04-06hr    141 embryo 06-08hr    92 embryo 08-10hr    183 embryo 10-12hr    138 embryo 12-14hr    98 embryo 14-16hr    208 embryo 16-18hr    170 embryo 18-20hr    140 embryo 20-22hr    247 embryo 22-24hr    212 larva L1    144 larva L2    89 larva L3 12hr old    174 larva L3 puffstage 1-2    118 larva L3 puffstage 3-6    114 larva L3 puffstage 7-9    161 white prepupae new    165 white prepupae 12hr    108 white prepupae 24hr    69 pupae 2d postWPP    17 pupae 3d postWPP    29 pupae 4d postWPP    16 adult male 01day    4 adult male 05day    5 adult male 30day    10 adult female 01day    365 adult female 05day    582 adult female 30day    543 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0003450 expression level Developmental Stage   Expression Level embryo 00-02hr    795 embryo 02-04hr    529 embryo 04-06hr    141 embryo 06-08hr    92 embryo 08-10hr    183 embryo 10-12hr    138 embryo 12-14hr    98 embryo 14-16hr    208 embryo 16-18hr    170 embryo 18-20hr    140 embryo 20-22hr    247 embryo 22-24hr    212 larva L1    144 larva L2    89 larva L3 12hr old    174 larva L3 puffstage 1-2    118 larva L3 puffstage 3-6    114 larva L3 puffstage 7-9    161 white prepupae new    165 white prepupae 12hr    108 white prepupae 24hr    69 pupae 2d postWPP    17 pupae 3d postWPP    29 pupae 4d postWPP    16 adult male 01day    4 adult male 05day    5 adult male 30day    10 adult female 01day    365 adult female 05day    582 adult female 30day    543 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (795) embryo 02-04hr  (529) embryo 04-06hr  141 embryo 06-08hr    92 embryo 08-10hr  (183) embryo 10-12hr  138 embryo 12-14hr    98 embryo 14-16hr  (208) embryo 16-18hr  (170) embryo 18-20hr  140 embryo 20-22hr  (247) embryo 22-24hr  (212) larva L1  (144) larva L2    89 larva L3 12hr old  (174) larva L3 puffstage 1-2  118 larva L3 puffstage 3-6  114 larva L3 puffstage 7-9  (161) white prepupae new  (165) white prepupae 12hr  108 white prepupae 24hr    69 pupae 2d postWPP    17 pupae 3d postWPP    29 pupae 4d postWPP    16 adult male 01day    4 adult male 05day    5 adult male 30day    10 adult female 01day  (365) adult female 05day  (582) adult female 30day  (543) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    795 embryo 02-04hr    529 embryo 04-06hr    141 embryo 06-08hr    92 embryo 08-10hr    183 embryo 10-12hr    138 embryo 12-14hr    98 embryo 14-16hr    208 embryo 16-18hr    170 embryo 18-20hr    140 embryo 20-22hr    247 embryo 22-24hr    212 larva L1    144 larva L2    89 larva L3 12hr old    174 larva L3 puffstage 1-2    118 larva L3 puffstage 3-6    114 larva L3 puffstage 7-9    161 white prepupae new    165 white prepupae 12hr    108 white prepupae 24hr    69 pupae 2d postWPP    17 pupae 3d postWPP    29 pupae 4d postWPP    16 adult male 01day    4 adult male 05day    5 adult male 30day    10 adult female 01day    365 adult female 05day    582 adult female 30day    543 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    795 embryo 02-04hr    529 embryo 04-06hr    141 embryo 06-08hr    92 embryo 08-10hr    183 embryo 10-12hr    138 embryo 12-14hr    98 embryo 14-16hr    208 embryo 16-18hr    170 embryo 18-20hr    140 embryo 20-22hr    247 embryo 22-24hr    212 larva L1    144 larva L2    89 larva L3 12hr old    174 larva L3 puffstage 1-2    118 larva L3 puffstage 3-6    114 larva L3 puffstage 7-9    161 white prepupae new    165 white prepupae 12hr    108 white prepupae 24hr    69 pupae 2d postWPP    17 pupae 3d postWPP    29 pupae 4d postWPP    16 adult male 01day    4 adult male 05day    5 adult male 30day    10 adult female 01day    365 adult female 05day    582 adult female 30day    543 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    795 embryo 02-04hr    529 embryo 04-06hr    141 embryo 06-08hr    92 embryo 08-10hr    183 embryo 10-12hr    138 embryo 12-14hr    98 embryo 14-16hr    208 embryo 16-18hr    170 embryo 18-20hr    140 embryo 20-22hr    247 embryo 22-24hr    212 larva L1    144 larva L2    89 larva L3 12hr old    174 larva L3 puffstage 1-2    118 larva L3 puffstage 3-6    114 larva L3 puffstage 7-9    161 white prepupae new    165 white prepupae 12hr    108 white prepupae 24hr    69 pupae 2d postWPP    17 pupae 3d postWPP    29 pupae 4d postWPP    16 adult male 01day    4 adult male 05day    5 adult male 30day    10 adult female 01day    365 adult female 05day    582 adult female 30day    543 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0003450    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0003450 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0003450 expression level Tissue   Expression Level Larval Central Nervous System    0.8 Larval Midgut    2.2 Larval Hindgut    33 Larval Malpighian Tubules    1.4 Larval Fat Body    3.1 Larval Salivary Gland    0.8 Larval Trachea no informative data Larval Carcass no informative data Adult Head    4.7 Adult Eye    1 Adult Brain    3.2 Adult Thoracic-Abdominal Ganglion    2.5 Adult Crop    5.4 Adult Midgut    2.4 Adult Hindgut    7.6 Adult Malpighian Tubules    6.1 Adult Fat Body    3.5 Adult Salivary Gland    2.7 Adult Heart    2.175 Adult VirginFemale Spermatheca    0.6 Adult InseminatedFemale Spermatheca    2.1 Adult Ovary    30.7 Adult Testis    4 Adult Male Accessory Gland    5.9 Adult Carcass    9 Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    0.8 Larval Midgut    2.2 Larval Hindgut    33 Larval Malpighian Tubules    1.4 Larval Fat Body    3.1 Larval Salivary Gland    0.8 Larval Trachea no informative data Larval Carcass no informative data Adult Head    4.7 Adult Eye    1 Adult Brain    3.2 Adult Thoracic-Abdominal Ganglion    2.5 Adult Crop    5.4 Adult Midgut    2.4 Adult Hindgut    7.6 Adult Malpighian Tubules    6.1 Adult Fat Body    3.5 Adult Salivary Gland    2.7 Adult Heart    2.175 Adult VirginFemale Spermatheca    0.6 Adult InseminatedFemale Spermatheca    2.1 Adult Ovary    30.7 Adult Testis    4 Adult Male Accessory Gland    5.9 Adult Carcass    9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    0.8 Larval Midgut    2.2 Larval Hindgut    33 Larval Malpighian Tubules    1.4 Larval Fat Body    3.1 Larval Salivary Gland    0.8 Larval Trachea no informative data Larval Carcass no informative data Adult Head    4.7 Adult Eye    1 Adult Brain    3.2 Adult Thoracic-Abdominal Ganglion    2.5 Adult Crop    5.4 Adult Midgut    2.4 Adult Hindgut    7.6 Adult Malpighian Tubules    6.1 Adult Fat Body    3.5 Adult Salivary Gland    2.7 Adult Heart    2.175 Adult VirginFemale Spermatheca    0.6 Adult InseminatedFemale Spermatheca    2.1 Adult Ovary    30.7 Adult Testis    4 Adult Male Accessory Gland    5.9 Adult Carcass    9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    0.8 Larval Midgut    2.2 Larval Hindgut    33 Larval Malpighian Tubules    1.4 Larval Fat Body    3.1 Larval Salivary Gland    0.8 Larval Trachea no informative data Larval Carcass no informative data Adult Head    4.7 Adult Eye    1 Adult Brain    3.2 Adult Thoracic-Abdominal Ganglion    2.5 Adult Crop    5.4 Adult Midgut    2.4 Adult Hindgut    7.6 Adult Malpighian Tubules    6.1 Adult Fat Body    3.5 Adult Salivary Gland    2.7 Adult Heart    2.175 Adult VirginFemale Spermatheca    0.6 Adult InseminatedFemale Spermatheca    2.1 Adult Ovary    30.7 Adult Testis    4 Adult Male Accessory Gland    5.9 Adult Carcass    9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0003450 expression level Tissue   Expression Level Larval Central Nervous System    0.8 Larval Midgut    2.2 Larval Hindgut    33 Larval Malpighian Tubules    1.4 Larval Fat Body    3.1 Larval Salivary Gland    0.8 Larval Trachea no informative data Larval Carcass no informative data Adult Head    4.7 Adult Eye    1 Adult Brain    3.2 Adult Thoracic-Abdominal Ganglion    2.5 Adult Crop    5.4 Adult Midgut    2.4 Adult Hindgut    7.6 Adult Malpighian Tubules    6.1 Adult Fat Body    3.5 Adult Salivary Gland    2.7 Adult Heart    2.175 Adult VirginFemale Spermatheca    0.6 Adult InseminatedFemale Spermatheca    2.1 Adult Ovary    30.7 Adult Testis    4 Adult Male Accessory Gland    5.9 Adult Carcass    9 Expression Level Scale  None   Low  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    0.8 Larval Midgut    2.2 Larval Hindgut    33 Larval Malpighian Tubules    1.4 Larval Fat Body    3.1 Larval Salivary Gland    0.8 Larval Trachea no informative data Larval Carcass no informative data Adult Head    4.7 Adult Eye    1 Adult Brain    3.2 Adult Thoracic-Abdominal Ganglion    2.5 Adult Crop    5.4 Adult Midgut    2.4 Adult Hindgut    7.6 Adult Malpighian Tubules    6.1 Adult Fat Body    3.5 Adult Salivary Gland    2.7 Adult Heart    2.175 Adult VirginFemale Spermatheca    0.6 Adult InseminatedFemale Spermatheca    2.1 Adult Ovary    30.7 Adult Testis    4 Adult Male Accessory Gland    5.9 Adult Carcass    9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    0.8 Larval Midgut    2.2 Larval Hindgut    33 Larval Malpighian Tubules    1.4 Larval Fat Body    3.1 Larval Salivary Gland    0.8 Larval Trachea no informative data Larval Carcass no informative data Adult Head    4.7 Adult Eye    1 Adult Brain    3.2 Adult Thoracic-Abdominal Ganglion    2.5 Adult Crop    5.4 Adult Midgut    2.4 Adult Hindgut    7.6 Adult Malpighian Tubules    6.1 Adult Fat Body    3.5 Adult Salivary Gland    2.7 Adult Heart    2.175 Adult VirginFemale Spermatheca    0.6 Adult InseminatedFemale Spermatheca    2.1 Adult Ovary    30.7 Adult Testis    4 Adult Male Accessory Gland    5.9 Adult Carcass    9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    0.8 Larval Midgut    2.2 Larval Hindgut    33 Larval Malpighian Tubules    1.4 Larval Fat Body    3.1 Larval Salivary Gland    0.8 Larval Trachea no informative data Larval Carcass no informative data Adult Head    4.7 Adult Eye    1 Adult Brain    3.2 Adult Thoracic-Abdominal Ganglion    2.5 Adult Crop    5.4 Adult Midgut    2.4 Adult Hindgut    7.6 Adult Malpighian Tubules    6.1 Adult Fat Body    3.5 Adult Salivary Gland    2.7 Adult Heart    2.175 Adult VirginFemale Spermatheca    0.6 Adult InseminatedFemale Spermatheca    2.1 Adult Ovary    30.7 Adult Testis    4 Adult Male Accessory Gland    5.9 Adult Carcass    9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea no informative data Larval Carcass no informative data Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    4.7   NA  Eye    1   NA  Brain    3.2   0.8  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    2.5   NA  Crop    5.4   2.2  Midgut    2.4   33  Hindgut    7.6   1.4  Malpighian Tubules    6.1   3.1  Fat Body    3.5   0.8  Salivary Gland    2.7   NA  Heart    2.175   no informative data  Trachea    NA   NA  VirginFemale Spermatheca    0.6   NA  InseminatedFemale Spermatheca    2.1   NA  Ovary    30.7   NA  Testis    4   NA  Male Accessory Gland    5.9   no informative data  Carcass    9 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_26
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003450 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7996-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage | germline clone | non-rescuable maternal effect | recessive snk3R-235-15 snk3R-259-33 lethal | maternal effect snk1 viable, with Scer\GAL4pnr-MD237 snkGD5591 snkGD16301 Sterility Allele female sterile snk2 Other Phenotypes Allele wild-type snk+t13.5 snkA367V snkcSa snkL184F snkV182A snkV182S Phenotype manifest in Allele denticle belt | maternal effect (with snk1) snk2 denticle belt | maternal effect (with snk2) snk1 embryonic/first instar larval cuticle | maternal effect, with Scer\GAL4otu.T:Hsim\VP16 snkScer\UAS.P\T.T:Ivir\HA1 embryonic/first instar larval cuticle | ventral snkunspecified filzkorper | maternal effect (with snk1) snk2 filzkorper | maternal effect (with snk2) snk1
Classical Alleles ( 6 )
For All Classical Alleles Show
Allele of snk Class Mutagen Stocks Known lesion snk4 ethyl methanesulfonate 3 Yes snk1 amorphic allele - genetic evidence ethyl methanesulfonate 1 Yes snk2 amorphic allele - genetic evidence ethyl methanesulfonate 0 Yes snk3R-235-15 ethyl methanesulfonate 0 -- snk3R-259-33 ethyl methanesulfonate 0 -- snkunspecified 0 --
Alleles Carried on Transgenic Constructs ( 56 )
For All Alleles Carried on Transgenic Constructs Show
Allele of snk Class Mutagen Stocks Known lesion snkGD16301 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes snkGD5591 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes snkKK109589 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes snk+t13.5 in vitro construct - genomic fragment 0 Yes snkA367V in vitro construct - site directed mutagenesis 0 Yes snkACID in vitro construct - deletion 0 Yes snkCS1,5 in vitro construct - deletion 0 Yes snkCS2,4 in vitro construct - deletion 0 Yes snkCS2 in vitro construct - deletion 0 Yes snkCS3,6 in vitro construct - deletion 0 Yes snkCS3 in vitro construct - deletion 0 Yes snkCS4 in vitro construct - deletion 0 Yes snkCS5 in vitro construct - deletion 0 Yes snkCS6 in vitro construct - deletion 0 Yes snkcSa in vitro construct - minigene in vitro construct 0 Yes snkCYS1A in vitro construct - deletion 0 Yes snkD283E in vitro construct - site directed mutagenesis 0 Yes snkD283N in vitro construct - site directed mutagenesis 0 Yes snkG189E in vitro construct - site directed mutagenesis 0 Yes snkGerm.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes snkGLYDA in vitro construct - deletion 0 Yes snkH235K in vitro construct - site directed mutagenesis 0 Yes snkH235R in vitro construct - site directed mutagenesis 0 Yes snkL184A in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes snkL184F in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes snkL184K in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes snkL184P in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes snkL184V in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes snkM1 in vitro construct - site directed mutagenesis 0 Yes snkM2 in vitro construct - site directed mutagenesis 0 Yes snkMtnA.T:Ivir\HA1,T:Zzzz\His6,T:Hsap\MYC in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes snkP183L.L184L in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes snkP183R.L184R in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes snkP414S in vitro construct - site directed mutagenesis 0 Yes snkPRSNK in vitro construct - deletion 0 Yes snkS181I.V182E.P183G.L184R.S381A in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes snkS181I.V182E.P183G.L184R in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes snkS381A in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes snkS381T in vitro construct - site directed mutagenesis 0 Yes snkScer\UAS.P\T.T:Avic\GFP-m6 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes snkScer\UAS.P\T.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes snkSMSA.Germ.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes snkSNKK.Germ.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes snkV182A in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes snkV182G in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes snkV182S.P183N.L184R in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes snkV182S in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes snkXa in vitro construct 0 Yes snkXHO1-2 in vitro construct - deletion 0 Yes snkXHO1-3 in vitro construct - deletion 0 Yes snkXHO1-4 in vitro construct - deletion 0 Yes snkXHO2-3 in vitro construct - deletion 0 Yes snkXHO2-4 in vitro construct - deletion 0 Yes snkΔN.Scer\UAS.P\T.T:Avic\GFP-m6 in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes snkΔne.S381A in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes snkΔne.T:ea in vitro construct - coding region fusion in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel8157 (Ryder, 2004.4.26) Df(3R)ry36 (Anderson and Nusslein-Volhard, 1984, Clark and Chovnick, 1985, DeLotto and Spierer, 1986, Tearle and Nusslein-Volhard, 1987)
Not disrupted in	Df(3R)kar-lG27 (Anderson and Nusslein-Volhard, 1984, Tearle and Nusslein-Volhard, 1987) Df(3R)l26d (DeLotto and Spierer, 1986) Df(3R)LG27 (DeLotto and Spierer, 1986) Tp(3;1)ry35 (DeLotto and Spierer, 1986)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD5591} NA P{GD16301} NA P{KK109589} NA P{UASp-snk.GFP} NA P{UASp-snk.HA} NA P{UASp-snk.ΔN.GFP} NA characterization construct P{Germ-snk.myc} NA P{Germ-snk.SMSA} NA P{Germ-snk.SNKK} NA P{snk+13.5} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
protein processing inferred from genetic interaction with ea (Chasan et al., 1992) Toll signaling pathway inferred from genetic interaction with Tl (Stein and Nusslein-Volhard, 1992)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 8 terms )
Molecular Function
CV term Evidence References
peptidase activity traceable author statement (Lall and Patel, 2001) serine-type endopeptidase activity inferred from sequence or structural similarity with EMBL:AF053921 (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 1987.8.13, Coates et al., 2000, Ross et al., 2003) serine-type peptidase activity non-traceable author statement (van Eeden and St. Johnston, 1999)
Biological Process
CV term Evidence References
dorsal/ventral axis specification non-traceable author statement (Rushlow and Levine, 1990, Swiss-Prot Project Members, 1987.8.13, Lall and Patel, 2001) traceable author statement (Meister et al., 2000) maternal specification of dorsal/ventral axis, oocyte, germ-line encoded traceable author statement (Chasan et al., 1992, van Eeden and St. Johnston, 1999) proteolysis inferred from electronic annotation with InterPro:IPR001254, InterPro:IPR001314, InterPro:IPR018114 (FlyBase Curators et al., 2004-) non-traceable author statement (Ross et al., 2003) traceable author statement (Lall and Patel, 2001) Toll signaling pathway non-traceable author statement (Beutler and Poltorak, 2001) traceable author statement (Chasan et al., 1992, Kimbrell and Beutler, 2001)
Cellular Component
CV term Evidence References
extracellular region traceable author statement (Chasan et al., 1992)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions snk allele Gene References snkXa gd (Ponomareff et al., 2001)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 66694 DroID - A comprehensive database of gene and protein interactions. • FBgn0003450 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41607
Orthologs
Genome-wide drosophilid orthologs	Dana\GF17410 Dere\GG17080 Dgri\GH19195 Dmoj\GI24229 Dper\GL23147 Dpse\GA20752 Dsec\GM25963 Dvir\GJ10802 Dwil\GK10853 Dyak\GE24470
Curated drosophilid orthologs	Dpse\GA20752
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL007597-PA Aedes aegypti (mosquito) AGAP004318-PA Anopheles gambiae (mosquito) XP_001951510.1 Acyrthosiphon pisum (pea aphid) BGIBMGA001745-PA Bombyx mori (silk worm) CPIJ009112 Culex pipens (mosquito) ENSMODP00000023687 Monodelphis domestica (gray opossum) ENSOANP00000023526 Ornithorynchus anatinus (platypus) PHUM003444-PA Pediculus humanus (human body louse) XP_969745.2 Tribolium castaneum (red flour beetle) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB16209 NV22258 NV18190 NV10938 LH25945 LH25941 LH16669 LH21590 FBgn0241586 FBgn0212864 FBgn0198073 FBgn0191994 FBgn0191993 FBgn0180819 JGI_V11_236061 JGI_V11_97391 JGI_V11_312667 JGI_V11_97393 JGI_V11_312669 JGI_V11_43419 JGI_V11_43879 JGI_V11_97418 JGI_V11_43739 JGI_V11_320718 JGI_V11_246614 JGI_V11_105531 FBgn0080743 FBgn0160737 FBgn0146952 FBgn0126662 FBgn0109308 FBgn0094428 CPIJ016080 CPIJ002754 CPIJ002753 CPIJ002751 CPIJ009112 CPIJ009113 CPIJ019033 CPIJ019031 CPIJ018035 CPIJ018036 CPIJ018033 CPIJ018034 BGIBMGA012427 BGIBMGA011051 BGIBMGA004518 BGIBMGA001745 ACYPI006282 ACYPI001993 GB30378 GB30301 GB15640 CLIPC3 CLIPC2 AGAP013221 AGAP012946 AGAP003627 CLIPC11 AAEL010867 AAEL007969 AAEL005654 PB22539 PB22545 PHUM003150 PHUM452840 GLEAN_13415 GLEAN_04160 GLEAN_04084
Stocks & Reagents
Stocks Listed in FlyBase ( 9 )
Bloomington	9037 mwh1 snk4 red1 e1/TM1 3114 st1 snk1 e1/TM8, l(3)DTS41 3338 mwh1 kniri-1 snk4 red1 e1 Tl3 ca1/Ms(3)R241/TM3, Sb1 29025 w1118; Df(3R)BSC841/mwh1 kniri-1 snk4 red1 e1 Tl3 ca1/TM6C, Sb1 cu1
VDRC	v107337 P{KK109589}VIE-260B v19928 w1118 P{GD5591}v19928 v19929 w1118 P{GD5591}v19929 v49538 w1118; P{GD16301}v49538 v49539 w1118; P{GD16301}v49539
Genomic Clones ( 1 )
	BACR48D15 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 15 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP03044
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	EC051359 EC051472 EC052313 EC052450 EC053327 EC053787 EC054360 EC054827 EC055020 EC055046 EC055793 EC056341 EC056352 EC056593
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0003450 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41607
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments	FlyBase curator comment: the insertion in the "e03379" Exelixis line (PBac{RB}CG11670e03379) was originally assigned to the snk gene in FBrf0179797, resulting in the "snke03379" (FBal0158624) allele. However, FBrf0184340 shows that the insertion is actually within CG11670. (Bloomington Drosophila Stock Center, 2004.11.6)
Other Comments
	Embryonic extracts derived from a cross between snk mutant mothers and Oregon R males lack the 80 kD ea-Spn27A protein complex seen in wild type embryonic extracts. (LeMosy, 2006) Neither ea or snk are required for the control of Drs gene expression. (Lemaitre et al., 1996) The level of activated snk protease can define cell fates along the dorsal-ventral axis in a concentration-dependent manner. Asymmetric injection of activated snk protease into wild type embryos suggests that the embryos may generate a snk activation gradient with a high point on the ventral side and a low point on the dorsal side. snk and ea proteases are members of a sequential protease activation pathway, snk and ea interact with other components of the dorsal-ventral pathway. (Smith and DeLotto, 1994) The snk serine protease contains at least two functional domains in its proenzyme polypeptide chain. One domain, the DSN, is potentially important for the interaction of the snk product with other components of the dorsal-ventral signalling pathway. (Smith et al., 1994) Responds most strongly of all maternal dorsalized mutants to rescue by injection of cytoplasm and poly(A)+ RNA from wild-type embryos. Injection of wild-type cytoplasm or cytoplasm from other dorsalizing maternal-effect mutants into pre-pole-cell snake embryos fully restores the normal dorsal-ventral pattern and more than 20% can develop into normal adults; the site of injection appears to be unimportant. Partial rescue also achieved by the injection of polyA+ but not poly(A)- RNA isolated from cleaving embryos. (Lindsley and Zimm, 1992) snk activity is involved in the production of the Tl ligand. (Stein and Nusslein-Volhard, 1992) In the absence of snk activity in the perivitelline fluid no Tl ligand is detected. (Stein and Nusslein-Volhard, 1992) Strong dorsalizing mutants of snk have wild type axial ratios in pupae. (Letsou et al., 1991) Mutations in maternal dorsal class gene snk do not interact with RpII140wimp. (Parkhurst and Ish-Horowicz, 1991) Involved in the regulatory hierarchy responsible for the asymmetric distribution and function of zygotic regulatory gene products along the DV axis of early embryos. (Rushlow and Levine, 1990) Molecular cloning and analysis of snk. (DeLotto and Spierer, 1986)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079614 NM_001104296 RefSeq (Proteins) • NP_524338 NP_001097766 DDBJ / EMBL / GenBank • AAF54897 ABW08657 CAA28197 X04513 Entrez Gene - A searchable database of RefSeq genes. • 41607 UniProtKB/Swiss-Prot • P05049
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Peptidase S1/S6, chymotrypsin/Hap, active site (IPR018114) Peptidase S1/S6, chymotrypsin/Hap (IPR001254) Peptidase S1A, chymotrypsin-type (IPR001314) Disulphide knot CLIP (IPR006604) Peptidase cysteine/serine, trypsin-like (IPR009003) MEROPS - An information resource for peptidases and the proteins that inhibit them • S01.200
Linkouts
	BioGRID - A database of protein and genetic interactions • 66694 DroID - A comprehensive database of gene and protein interactions. • FBgn0003450 DRSC - Results from RNAi screens. • FBgn0003450 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003450 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7996-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0003450 FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways • 101867 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41607 InParanoid A subset of ortholog calls from InParanoid. • AAEL007597-PA Aedes aegypti (mosquito) AGAP004318-PA Anopheles gambiae (mosquito) XP_001951510.1 Acyrthosiphon pisum (pea aphid) BGIBMGA001745-PA Bombyx mori (silk worm) CPIJ009112 Culex pipens (mosquito) ENSMODP00000023687 Monodelphis domestica (gray opossum) ENSOANP00000023526 Ornithorynchus anatinus (platypus) PHUM003444-PA Pediculus humanus (human body louse) XP_969745.2 Tribolium castaneum (red flour beetle) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41607 modMine - Data generated by the modENCODE project. • FBgn0003450 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB16209 NV22258 NV18190 NV10938 LH25945 LH25941 LH16669 LH21590 FBgn0241586 FBgn0212864 FBgn0198073 FBgn0191994 FBgn0191993 FBgn0180819 JGI_V11_236061 JGI_V11_97391 JGI_V11_312667 JGI_V11_97393 JGI_V11_312669 JGI_V11_43419 JGI_V11_43879 JGI_V11_97418 JGI_V11_43739 JGI_V11_320718 JGI_V11_246614 JGI_V11_105531 FBgn0080743 FBgn0160737 FBgn0146952 FBgn0126662 FBgn0109308 FBgn0094428 CPIJ016080 CPIJ002754 CPIJ002753 CPIJ002751 CPIJ009112 CPIJ009113 CPIJ019033 CPIJ019031 CPIJ018035 CPIJ018036 CPIJ018033 CPIJ018034 BGIBMGA012427 BGIBMGA011051 BGIBMGA004518 BGIBMGA001745 ACYPI006282 ACYPI001993 GB30378 GB30301 GB15640 CLIPC3 CLIPC2 AGAP013221 AGAP012946 AGAP003627 CLIPC11 AAEL010867 AAEL007969 AAEL005654 PB22539 PB22545 PHUM003150 PHUM452840 GLEAN_13415 GLEAN_04160 GLEAN_04084
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	CG7996 (Irving et al., 2001, Keleman et al., 2009.8.5) c-SP26 (Ross et al., 2003) l(3)87Dg   me(3)4   snk (LeMosy, 2006, Tian and LeMosy, 2008, Stein et al., 2008, DeLotto, 2001, Baker et al., 2007, Cho et al., 2010, Leclerc et al., 2006, Steen et al., 2010) SNK (Tang et al., 2006) SP26 (Ross et al., 2003)
Name Synonym	snake (LeMosy, 2006, Leclerc et al., 2006, Cho et al., 2010) Snake (Christophides et al., 2002, Stein et al., 2008, Zhou et al., 2008, Shah et al., 2008) Snake, (Stein et al., 2010)
Secondary FlyBase IDs
	FBgn0015383
References ( 140 )
Generate a list of	All references relating to this gene ( 140 )
List References by type	Research paper  ( 68 ) Supplementary material  ( 3 ) Review  ( 45 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 9 ) FlyBase analysis  ( 1 ) Stock list  ( 1 ) Book  ( 1 ) Protein sequence record  ( 1 ) Computer file  ( 1 ) Curated genome annotation  ( 1 ) Automatic genome annotation  ( 1 ) Spoof  ( 1 ) Biography  ( 1 )
Recent research papers ( 3 )
	Cho et al., 2010, Curr. Biol. 20(12): 1133--1137 Pipe-Dependent Ventral Processing of Easter by Snake Is the Defining Step in Drosophila Embryo DV Axis Formation. [FBrf0211253] Steen et al., 2010, FEBS Lett. 584(16): 3557--3560 Activation of Snake in a serine protease cascade that defines the dorsoventral axis is atypical and pipe-independent in Drosophila embryos. [FBrf0211517] Stein et al., 2010, Curr. Biol. 20(21): 1953--1958 Localization and Activation of the Drosophila Protease Easter Require the ER-Resident Saposin-like Protein Seele. [FBrf0212238] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...