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General Information
Symbol
Dmel\sog
Species
D. melanogaster
Name
short gastrulation
Annotation Symbol
CG9224
Feature Type
FlyBase ID
FBgn0003463
Gene Model Status
Stock Availability
Gene Snapshot
short gastrulation (sog) encodes a secreted BMP antagonist that is expressed in the embryonic ventral neuroectoderm. sog product promotes neural development by preventing dorsally produced dpp from diffusing into the neuroectoderm and suppressing expression of neural genes. sog protein also diffuses dorsally where it helps establish a BMP activity gradient essential for partitioning that domain into cells giving rise to the dorsal epidermis versus amnioserosa. [Date last reviewed: 2018-09-20]
Also Known As
l(1)G0479, l(1)G0160, l(1)G0395
Key Links
Genomic Location
Cytogenetic map
Sequence location
X:15,603,283..15,633,434 [-]
Recombination map
1-51
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Protein Family (UniProt)
Belongs to the chordin family. (Q24025)
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
Predictions / Assertions
-
Summaries
Pathway (FlyBase)
Negative Regulators of BMP Signaling Pathway -
Negative regulators of Bone Morphogenetic Protein (BMP) signaling down-regulate the pathway, ultimately resulting in the decreased nuclear activity of the Mad/Med transcription factor complex.
Positive Regulators of BMP Signaling Pathway -
Positive regulators of Bone Morphogenetic Protein (BMP) signaling up-regulate the pathway, ultimately resulting in the increased nuclear activity of the Mad/Med transcription factor complex.
Protein Function (UniProtKB)
Putative negative growth factor (PubMed:7958919). Antagonist of dpp, a protein involved in patterning the dorsal region and in the development of the neuroectoderm; dpp inhibition is enhanced by tsg (PubMed:7958919). Required for establishment of a narrow stripe of peak levels of BMP signaling in the dorsal midline of early embryos, that will give rise to the amnioserosa (PubMed:11260716).
(UniProt, Q24025)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
sog: short gastrulation
Embryonic lethal with weak ventralized phenotype. Invagination and subsequent closing of the posterior midgut and anterior midgut delayed; germ-band extension incomplete; dorsal-most cells fail to assume normal amnioserosal fate; they are abnormally thick and fall into deep dorsal folds at the time of germ-band extension. Mosaic studies indicate that sog expression required only ventrally for normal development. No discernable maternal effect.
Summary (Interactive Fly)
chordin homolog - a Dpp antagonist involved in the determination of dorsal/ventral polarity - leads to the subdivision of the dorsal region of the fly into amnioserosa and dorsal ectoderm
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\sog or the JBrowse view of Dmel\sog for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
RNA-Seq data support additional isoforms with extended 3' UTRs of differing length, some of which appear to be stage and/or tissue specific.
Gene model reviewed during 5.45
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.50
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0074063
4523
1038
FBtr0331760
4841
1038
FBtr0340346
5816
1038
Additional Transcript Data and Comments
Reported size (kB)
7 (northern blot)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0073879
115.5
1038
8.20
FBpp0304148
115.5
1038
8.20
FBpp0309304
115.5
1038
8.20
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1038 aa isoforms: sog-PA, sog-PB, sog-PE
Additional Polypeptide Data and Comments
Reported size (kDa)
120 (kD observed)
Comments
External Data
Subunit Structure (UniProtKB)
Component of a complex composed of dpp, sog and tsg (PubMed:11260716). Interacts with palmitoyltransferase Hip14 (PubMed:20599894).
(UniProt, Q24025)
Post Translational Modification
Palmitoylated, probably by Hip14.
(UniProt, Q24025)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\sog using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (13 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (0 terms)
Biological Process (10 terms)
Terms Based on Experimental Evidence (10 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from mutant phenotype
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (0 terms)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
mesectoderm anlage

Comment: anlage in statu nascendi

ventral ectoderm anlage

Comment: anlage in statu nascendi

antennal anlage

Comment: reported as procephalic ectoderm anlage

central brain anlage

Comment: reported as procephalic ectoderm anlage

dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

visual anlage

Comment: reported as procephalic ectoderm anlage

ventral nerve cord primordium

Comment: reported as ventral nerve cord anlage

wing cell | subset

Comment: reference states 18-20 hr APF

wing cell

Comment: reference states 25-30 hr APF

Additional Descriptive Data
Expression pattern inferred from unspecified enhancer trap line.
sog is expressed in lateral stripes in the presumptive neurogenic ectoderm.
In wing and leg imaginal discs, sog transcript is expressed in stripes running parallel to the dpp stripe along the compartment border. sog and dpp transcripts are expressed in complementary patterns during pupal wing vein development. sog transcript is first detected in 18-20 hr pupae, in the center of the intervein domains. By 25-30 hr, sog is expressed in most of the intervein cells. Double labeling experiments with sog and dpp transcripts show that sog and dpp are expressed in a strictly complementary pattern in most of the pupal wing, with the exception of the L5 vein, where there is a one-cell-wide gap between sog and dpp expressing cells.
During cycle 14, sog is expressed in a broad lateral stripe 14-16 cells wide. The dorsal boundary of the sog expression domain abuts the ventral boundary of the dpp domain as early as cycle 13. Later, sog expression fades from its dorsal limits and there is a gap between the sog and dpp expression domains. The ventral border of the sog expression domain is marked by the mesectoderm and includes the single row of mesectodermal cells. sog expression is progressively lost dorsally during late blastoderm and early gastrulation. By germ band extension, the transcripts are confined to the ventral midline. Transcripts are localized apically within the cells. At full germ band extension, sog is expressed in a pattern of lateral patches dorsal to the tracheal pits that fuse to form a lateral stripe running between the two stripes of dpp expression. After germ band retraction, sog is expressed in ventral epidermal cells in a pattern resembling the outline of future denticle belts. Internally, sog is expressed in a series of bands in the endoderm of the gut and in the esophagus. While generally out of phase, endodermal cells expressing sog and visceral mesoderm cells expressing dpp are in contact at the junction of the gut with the esophagus.
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
In cellular blastoderm embryos, high levels of sog protein strongly colocalizes with sog transcript in two broad ventro-lateral stripes. Lower levels localize to the ventral mesoderm and dorsal ectoderm. Localization in the dorsal ectoderm is graded, with highest levels in the region adjacent to the ventral neurogenic region. The dorsal ventral gradient is more pronounced in late blastoderm embryos.
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
Stage
Tissue/Position (including subcellular localization)
Reference
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\sog in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 48 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 56 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of sog
Transgenic constructs containing regulatory region of sog
Deletions and Duplications ( 7 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
14 of 15
Yes
Yes
1 of 15
No
Yes
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
14 of 15
Yes
Yes
1 of 15
No
Yes
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (3)
13 of 13
Yes
Yes
1 of 13
No
Yes
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (2)
12 of 12
Yes
Yes
1 of 12
No
Yes
Danio rerio (Zebrafish) (2)
14 of 15
Yes
Yes
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
2 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091901BN )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501BH )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01ZC )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X09RD )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G11A0 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    suppressible
    suppressible
    suppressible
    External Data
    Subunit Structure (UniProtKB)
    Component of a complex composed of dpp, sog and tsg (PubMed:11260716). Interacts with palmitoyltransferase Hip14 (PubMed:20599894).
    (UniProt, Q24025 )
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Gene Group - Pathway Membership (FlyBase)
    Negative Regulators of BMP Signaling Pathway -
    Negative regulators of Bone Morphogenetic Protein (BMP) signaling down-regulate the pathway, ultimately resulting in the decreased nuclear activity of the Mad/Med transcription factor complex.
    Positive Regulators of BMP Signaling Pathway -
    Positive regulators of Bone Morphogenetic Protein (BMP) signaling up-regulate the pathway, ultimately resulting in the increased nuclear activity of the Mad/Med transcription factor complex.
    External Data
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    X
    Recombination map
    1-51
    Cytogenetic map
    Sequence location
    X:15,603,283..15,633,434 [-]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    13E1-13E1
    Limits computationally determined from genome sequence between P{EP}CG6340EP1109&P{EP}l(1)G0168EP491 and P{EP}EP1489
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    13E1-13E4
    (determined by in situ hybridisation) 13D--E1 (determined by in situ hybridisation) 13E1--4 (determined by in situ hybridisation)
    13D1-13E4
    (determined by in situ hybridisation)
    13E1-13E4
    (determined by in situ hybridisation)
    Experimentally Determined Recombination Data
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (18)
    Genomic Clones (23)
    cDNA Clones (101)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for identity of: sog CG9224
    Source for database merge of
    Source for merge of: sog l(1)G0395 l(1)G0479 l(1)G0160
    Additional comments
    "l(1)G0123" may affect "sog".
    One of sog1 to sog6 is temperature-sensitive.
    Other Comments
    CalpA is epistatic to sog.
    sog preferentially binds to a dpp/gbb heterodimer, rather than to each protein on its own.
    Mutant embryos lack the corpus cardiacum.
    The dpp gene product is widely diffusible in the presence of sog protein but tightly localised in its absence.
    sog protein has a graded distribution across the dorsal side of blastoderm embryos.
    sog functions cell non-autonomously to elevate BMP signaling on the dorsal side of the embryo. The positive function of sog protein may be directed towards dpp rather than scw.
    sog and dpp reduce translocation of dl protein into the nucleus.
    sog and dpp exert opposing maternal functions to modify Tl signaling and pattern the dorsoventral axis of the embryo.
    tld protein cleaves sog protein. Cleavage is stimulated by dpp protein.
    sog plays a local role in the lateral region of the blastoderm embryos to oppose dpp activity in the neuroectoderm. sog protects the neuroectoderm from an invasive positive feedback loop created by dpp diffusion and autoactivation. sog functions as a diffusible morphogen in the blastoderm embryo.
    sog and Xlae\noggin do not show a synergistic interaction in their capability to induce ventral fates in preblastoderm embryos.
    sog is expressed in complementary intervein cells and suppresses vein formation. sog and dpp are expressed in complementary patterns during pupal wing vein development and function during the same phenocritical period to influence the vein versus intervein cell fate choice. dpp promotes vein fates indirectly by activating rho and sog functions by blocking an autoactivating dpp feedback loop. These data support the view that sog is a dedicated dpp antagonist.
    Injection of sog mRNA into embryos from dl mutant mothers is sufficient to promote the formation of dorsal-lateral structures, indicating that sog can be sufficient to promote ventralisation of the ectodermal pattern.
    sog and Xlae\chordin protein function in dorsal-ventral axis formation.
    sog is required ventrally to enforce the identity of the neuroectoderm against the dorsalizing activity of dpp.
    Data presented by FBrf0083197 supports Geoffroy St-Hilaire's theory of dorsal-ventral inversion between vertebrate and arthropod embryos. Results suggest that two classes of signalling molecule (dpp and sog) represent counteracting systems that control dorsal-ventral patterning and might have been established in a primitive ancestor before the divergence of the arthropods and vertebrates.
    sog, which is expressed in the ventrolateral region of the embryo that gives rise to the nerve cord, is functionally homologous to the chordin gene of Xenopus, which is expressed in the dorsal blastopore lip of the embryo and in dorsal mesoderm, in particular the notochord. sog antagonises the dorsalising effects of dpp.
    Genetic and phenotypic data reveals that sog is involved in post-transcriptional regulation of dpp activity by blocking dpp activity ventrally.
    Expression of sog in Xenopus embryos suggests that the mechanism of dorsal-ventral patterning may be conserved between the evolutionarily distinct organisms.
    tld, srw and sog are required to generate a gradient of dpp activity which directly specifies the pattern of the dorsal 40% of the embryo.
    sog is required for the normal ontogeny of the zen pattern and fating of the amnioserosa.
    Zygotically active locus involved in the terminal developmental program in the embryo.
    Involved in the regulatory hierarchy responsible for the asymmetric distribution and function of zygotic regulatory gene products along the DV axis of early embryos. sog is required for the refinement of the zen expression pattern during cellularization and gastrulation: zen products do not become restricted to the presumptive amnioserosa.
    Identification: A screen for X-linked genes that affect embryo morphology revealed sog.
    sog mutants display incomplete germ band extension, head and spiracles defective in posterior cuticle.
    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 54 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
    InterPro - A database of protein families, domains and functional sites
    KEGG Genes - Molecular building blocks of life in the genomic space.
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    modMine - A data warehouse for the modENCODE project
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyMine - An integrated database for Drosophila genomics
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Synonyms and Secondary IDs (14)
    Reported As
    Symbol Synonym
    sog
    (Whittle and Extavour, 2019, Auman and Chipman, 2017, Shin and Hong, 2017, Tian et al., 2017, Upadhyay et al., 2017, Wells et al., 2017, Esposito et al., 2016, Kang et al., 2016, Levario et al., 2016, Matsuda et al., 2016, Moulton and Letsou, 2016, Quijano et al., 2016, Shin and Hong, 2016, Wieschaus and Nüsslein-Volhard, 2016, O'Connell and Reeves, 2015, Sawala et al., 2015, Schleede and Blair, 2015, Shin and Hong, 2015, Sun et al., 2015, Winstanley et al., 2015, Ashwal-Fluss et al., 2014, DeSalvo et al., 2014, Foo et al., 2014, Hodar et al., 2014, Mannervik, 2014, Rembold et al., 2014, Hattori et al., 2013, Khan et al., 2013, Lagha et al., 2013, Müller et al., 2013, Saunders et al., 2013, Shimmi and Newfeld, 2013, Webber et al., 2013, Chen et al., 2012, Chopra et al., 2012, Haskel-Ittah et al., 2012, Helman et al., 2012, Holmqvist et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Kanodia et al., 2012, Reeves et al., 2012, Rushlow and Shvartsman, 2012, Sawala et al., 2012, Stinchfield et al., 2012, Umulis and Othmer, 2012, Bothma et al., 2011, Garcia and Stathopoulos, 2011, Kanodia et al., 2011, Lott et al., 2011, Lynch and Roth, 2011, Mrinal et al., 2011, Nien et al., 2011, Ozdemir et al., 2011, Park et al., 2011, Peluso et al., 2011, Pilgram et al., 2011, Tsurumi et al., 2011, Leatherman and Dinardo, 2010, Negreiros et al., 2010, Popodi et al., 2010-, Umulis et al., 2010, Venken et al., 2010, Birkholz et al., 2009, Boettiger and Levine, 2009, Cande et al., 2009, Dworkin et al., 2009, Evans et al., 2009, Fontenele et al., 2009, Lander et al., 2009, Liberman and Stathopoulos, 2009, Liberman et al., 2009, Papatsenko et al., 2009, Beaver et al., 2008, Fu and Levine, 2008, Hong et al., 2008, Kim et al., 2008, Liang et al., 2008, Miles et al., 2008, Qi et al., 2008, Carneiro and Araujo, 2007, Halfon and Arnosti, 2007, Hatton-Ellis et al., 2007, Lecuyer et al., 2007, Muse et al., 2007, Zeitlinger et al., 2007, Zeitlinger et al., 2007, Zeitlinger et al., 2007, Zeng et al., 2007, Araujo et al., 2006, Biemar et al., 2006, Carneiro et al., 2006, Lin et al., 2006, Mizutani et al., 2006, Prothmann et al., 2006, Ratnaparkhi et al., 2006, Umulis et al., 2006, Zinzen et al., 2006, Leptin, 2005, Mizutani et al., 2005, Stathopoulos and Levine, 2005, Xavier-Neto, 2005, Gurunathan et al., 2004, Markstein et al., 2004, Ronshaugen and Levine, 2004, Cowden and Levine, 2003, Chen et al., 2000)
    Secondary FlyBase IDs
    • FBgn0027206
    • FBgn0028353
    • FBgn0029046
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    References (426)