A Database of Drosophila Genes & Genomes

FB2013_03, released May 7th, 2013
 

Gene Dmel\sp

General Information
SymbolDmel\spSpeciesD. melanogaster
NamespeckAnnotation symbol
Feature typegeneFlyBase IDFBgn0003466
Gene Model StatusUnannotated Stock availability 526 publicly available
Genomic Location
Chromosome (arm)Recombination map2-107.0
Cytogenetic map60C1-60C2Sequence location
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Automatically generated summary

See sections below for more information
The gene speck is referred to in FlyBase by the symbol Dmel\sp (FBgn0003466). It is a gene from Drosophila melanogaster. Its molecular function is unknown. The biological processes in which it is involved are not known. 7 alleles are reported. No phenotypic data is available. It has no annotated transcripts. Gene has not been localized to the genome sequence.

User Contributed Data
hide Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage
sp: speck
thumb
sp: speck
From Bridges and Morgan, 1919, Carnegie Inst. Washington Publ. No. 278: 129.
Axils of wings have black specks. Body color dark. In pupa, region of anal papilla is dark (Waddington). Displays a marked decrease in the amount of the A2 component of phenoloxidase; levels restored to normal in presence of su(s)2 (Warner, Grell, and Jacobsen, 1975, Biochem. Genet. 13: 353-56). RK1.
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Description
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FB2013_03
FB2013_02
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hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
60C1-60C2  
Left limit from complementation mapping against In(2R)XP23 (FBrf0051917) Right limit from complementation mapping against In(2R)XP26 (FBrf0051917)  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
Experimentally Determined Recombination Data
Location
2-107.0
(Meyer, 1963)
Left of (cM)
(Ives, 1967)
Right of (cM)
(Ives, 1967)
Notes
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Comments on Gene Model
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Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
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Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
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Type
Symbol & Location
Additional Notes
References
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Linkouts
Crossreferences
hide Expression Data
hideTranscript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
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Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term
Evidence
References
hide Expression Deduced from Reporters
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Associated Tools
Reference
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
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Linkouts
hide Alleles & Phenotypes
hide Summary of Allele Phenotypes
Other Phenotypes
Allele
body color defective
visible | recessive
Phenotype manifest in
Allele
hide Classical Alleles ( 7 )
For All Classical Alleles Show

Allele of spClassMutagenStocksKnown lesion
sp1409 Yes
sp2
126 --
spP20 --
spS610 --
spu0 --
spXP230 --
spXP260 --
hide Alleles Carried on Transgenic Constructs ( 0 )
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Allele of spClassMutagenStocksKnown lesion
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Disrupted in
(Bridges, 1937, Peng and Mount, 1990)
(Peng and Mount, 1990)
(Slizynska, 1942)
(Slizynska, 1942)
(Slizynska, 1942)
(Slizynska, 1942)
(Slizynska, 1942)
(Slizynska, 1942)
(Slizynska, 1942)
(Peng and Mount, 1990)
(Peng and Mount, 1990)
(Peng and Mount, 1990)
 
Duplicated in
 
(Baker and Rubin, 1992)
Not disrupted in
(Bloomington Drosophila Stock Center, 1998.6.2)
(Bridges, 1937, Kimble et al., 1990)
(Thompson, 1963)
Not duplicated in
(Gethmann, 1967)
hide Transgenic Constructs & Insertions
Transgenic Constructs
Type of construct
Name
Expression data
characterization construct
P{UAS-IR-w.sp}
NA
Insertions
Type of insertions
Name
Expression data
miscellaneous insertions
412{}sp1a
NA
P{}spP2
NA
roo{}sp1b
NA
hide Gene Ontology: Function, Process & Cellular Component ( 0 unique terms )
hide Terms Based on Experimental Evidence ( 0 terms )
hide Terms Based on Predictions or Assertions ( 0 terms )
hide Sequence Ontology: Class of Gene
gene
 
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Interacts with
Please look at the allele data for full details of the genetic interactions
sp allele
Gene
References
sp1
su(s)
(Warner et al., 1975)
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Linkouts
DroID - A comprehensive database of gene and protein interactions.
•
InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.
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hide Orthologs
hide OrthoDB Orthologs (0) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
OrthoDB orthology group searches
(Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288)
Drosophila inclusive ortholog search
No orthologs identified
Dipteran inclusive ortholog search
No orthologs identified
Insect inclusive ortholog search
No orthologs identified
Arthropod inclusive ortholog search
No orthologs identified
Metazoa inclusive ortholog search
No orthologs identified
Orthologs in Drosophila Species (None identified)
No orthologies identified
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
hide Human Orthologs (0)
Gene
OMIM
HGNC
hideAAA Orthologs (0) based on analysis using Dmel annotation version 4.3
No orthologs identified
hide Stocks & Reagents
hide Stocks Listed in FlyBase ( 526 )
Bloomington
403
sp2 bs2
8540
Dp(2;2)Cam3b, sp1/CyO
32006
egl1 sp1/SM6a
1020
C(2)EN, bw1 sp1
4455
cn1 bw1 sp1
381
px1 slt1 sp1
6534
Df(2R)K11, bw1 sp1/SM1
Kyoto
105894
sp2 bs2
101430
Df(2L)RA5, sp1 / CyO
101341
C(2)EN, bw1 sp1
107753
cn1 bw1 sp1
108822
Df(2R)K11, bw1 sp1/SM1
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cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
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Linkouts
GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
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Source for database identity of
Source for database merge of
Additional comments
FlyBase curator comment: FBrf0044478 showed that lesions in the gene corresponding to the CG10484 annotation reduce the activity of the A2 component of phenol oxidase originally described in FBrf0017315, while the A1 and A3 phenol oxidase components originally described in FBrf0017315 are unaffected in these mutant alleles. Thus FBrf0044478 states that the mutants probably identify a structural locus for the A2 phenol oxidase component and designated this locus "Diphenol oxidase-A2, Dox-A2". However, cloning of the gene in FBrf0054017 revealed that the encoded protein had no homology to non-insect phenol oxidases at that time, but instead shows high amino acid identity (57% over the entire length of the D. melanogaster protein) to the mouse Psmd3 gene (accession number MGI:48687), which encodes a proteasome subunit. FBrf0128494 showed that the protein encoded by the CG10484 annotation is a subunit of the regulatory complex of the 26S proteasome in D. melanogaster. FBrf0058767 suggests that the A2 component of phenol oxidase seen in FBrf0017315 could have been an artificial derivative produced from either the A1 or A3 components by the activity of endogenous proteases during extraction, since protease inhibitors were not used in sample preparation (the A2 phenol oxidase component was not detected in FBrf0058767 where serine proteases inhibitors were present during sample preparation). Alternatively, FBrf0027144 shows that the speck (sp) mutants have a marked decreased in the amount of the A2 component of phenol oxidase, and thus FBrf0044480 notes that the A2 component may be a dimer of two non-identical subunits coded for by "Dox-A2" and sp. Given the uncertainty over whether the gene corresponding to the CG10484 annotation does encode a structural locus for the A2 component of phenol oxidase, but the good evidence that it is a proteasome subunit, the gene has been renamed to "Rpn3, Regulatory particle non-ATPase 3" following the nomenclature used in FBrf0152082, which uses the nomenclature used for S. cerevisiae proteasome regulatory particle subunits described in PubMed:9697412. In addition, the annotation corresponding to the gene has been renamed from CG10484 to CG42641 in release 5.22 of the genome annotation.
(Millburn, 2009.9.4)
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Sequence Crossreferences
Other Crossreferences
Linkouts
DroID - A comprehensive database of gene and protein interactions.
•
GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
•
InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.
•
hide Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym
sp
(Whitlock and Bourguet, 2000, Wright, 1987, Millburn, 2009.9.4)
Name Synonym
speck
(Whitlock and Bourguet, 2000, Batterham and MacKechnie, 1980, Wright, 1987, Millburn, 2009.9.4)
Secondary FlyBase IDs
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