• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • CytoSearch
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Downloads:
  • Precomputed files
  • Archived data
  • Releases (FTP)
  • Genomes (FTP)
  • AAA data (FTP)
  • Lists:
  • Transposons (Dmel)
  • Transposons (other)
  • Vectors & Constructs
  • Anatomical Terms
  • Map Conversion
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Other links:
  • BDGP
  • DGRC
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\spn-A

General Information
Symbol	Dmel\spn-A	Species	D. melanogaster
Name	spindle A	Annotation symbol	CG7948
Feature type	protein_coding_gene	FlyBase ID	FBgn0003479
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	Rad51, spnA, DmRad51, DMR
Genomic Location
Chromosome (arm)	3R	Recombination map	3-96
Cytogenetic map	99D3-99D3	Sequence location	3R:25,880,418..25,881,767 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene spindle A is referred to in FlyBase by the symbol Dmel\spn-A (CG7948, FBgn0003479). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: recombinase activity. There is experimental evidence that it is involved in the biological process: germarium-derived oocyte fate determination; female meiosis; double-strand break repair via synthesis-dependent strand annealing; polarity specification of dorsal/ventral axis; intracellular mRNA localization; cell cycle checkpoint; oogenesis; polarity specification of anterior/posterior axis; karyosome formation. 29 alleles are reported. The phenotypes of these alleles are annotated with: germline cyst; chorion; egg; oocyte; presumptive oocyte; karyosome; egg chamber; dorsal appendage; nurse cell; synaptonemal complex. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: ATPase, AAA+ type, core; DNA recombination and repair protein Rad51, C-terminal; DNA recombination and repair protein, RecA-like; DNA recombination/repair protein Rad51; DNA recombination/repair protein RecA, monomer-monomer interface; DNA recombination/repair protein RecA/RadB, ATP-binding domain; DNA repair Rad51/transcription factor NusA, alpha-helical; Helix-hairpin-helix DNA-binding motif, class 1. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1640738_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of spn-A. Gene sequence location is 3R:25880418..25881767.
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	spn-A: spindle A Maternal-effect lethal. Egg shape affected; in extreme cases dorsal appendages are lacking and eggs have little or no dorsal-ventral polarity; some eggs have one fused dorsal appendage. Low fecundity; eggs often slightly collapsed.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	Sequence features BKN40561 HFA16812 References Chiolo et al., 2011, Cell 144(5): 732--744 Andersen et al., 2011, PLoS Genet. 7(10): e1002315 Lancaster et al., 2010, PLoS Genet. 6(10): e1001179
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 99D3-99D3   Limits computationally determined from genome sequence between P{PZ}ncd05884 and P{lacW}l(3)s2500s2500
Experimentally Determined Cytological Location
Cytogenetic map Notes References 99D-99D     (Akaboshi, 1995) 93D-93D   (determined by in situ hybridisation)   (McKee et al., 1996) 99D-99D   (determined by in situ hybridisation)   (Akaboshi et al., 1994) 99D3-99D6     (McKee, 1995.6.8)
Experimentally Determined Recombination Data
Location	3-96 (Tearle and Nusslein-Volhard, 1987, Gonzalez-Reyes et al., 1997) 3- (Akaboshi, 1995)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\spn-A for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.43
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) spn-A-RA FBtr0085589  NM_079844   1287   336 spn-A-RB FBtr0085590  NM_170463   1338   279
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein spn-A-PA   FBpp0084955   36.6   336   6.52     NP_524583   AAF57005 spn-A-PB   FBpp0084956   30.5   279   7.42     NP_733342   AAN14213
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • ATPase, AAA+ type, core (IPR003593) DNA repair Rad51/transcription factor NusA, alpha-helical (IPR010995) DNA recombination/repair protein Rad51 (IPR011941) DNA recombination and repair protein Rad51, C-terminal (IPR013632) Helix-hairpin-helix DNA-binding motif, class 1 (IPR003583) DNA recombination and repair protein, RecA-like (IPR016467) DNA recombination/repair protein RecA, monomer-monomer interface (IPR020587) DNA recombination/repair protein RecA/RadB, ATP-binding domain (IPR020588)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA979378   AE014297 AAF57005   AE014297 AAN14213   AI259851   AI455994   AI512877   BG638776   BG640472   BI574541   BI584842   BI636986   BP545902   BQ102918   BT001791 AAN71546   BT089037   CK131377   CK658856   CK659360   CO299430   D17726 BAA04580   D37788 BAA07039   EC199700   L41342 AAA64873
UniProtKB/Swiss-Prot	Q27297
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0003479    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0003479 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0003479 expression level Developmental Stage   Expression Level embryo 00-02hr    3153 embryo 02-04hr    1488 embryo 04-06hr    1909 embryo 06-08hr    1632 embryo 08-10hr    1306 embryo 10-12hr    993 embryo 12-14hr    555 embryo 14-16hr    500 embryo 16-18hr    401 embryo 18-20hr    390 embryo 20-22hr    288 embryo 22-24hr    329 larva L1    554 larva L2    443 larva L3 12hr old    340 larva L3 puffstage 1-2    444 larva L3 puffstage 3-6    649 larva L3 puffstage 7-9    775 white prepupae new    782 white prepupae 12hr    963 white prepupae 24hr    885 pupae 2d postWPP    588 pupae 3d postWPP    378 pupae 4d postWPP    323 adult male 01day    486 adult male 05day    561 adult male 30day    616 adult female 01day    814 adult female 05day    1230 adult female 30day    1448 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3153) embryo 02-04hr  (1488) embryo 04-06hr  (1909) embryo 06-08hr  (1632) embryo 08-10hr  (1306) embryo 10-12hr  (993) embryo 12-14hr  (555) embryo 14-16hr  (500) embryo 16-18hr  (401) embryo 18-20hr  (390) embryo 20-22hr  (288) embryo 22-24hr  (329) larva L1  (554) larva L2  (443) larva L3 12hr old  (340) larva L3 puffstage 1-2  (444) larva L3 puffstage 3-6  (649) larva L3 puffstage 7-9  (775) white prepupae new  (782) white prepupae 12hr  (963) white prepupae 24hr  (885) pupae 2d postWPP  (588) pupae 3d postWPP  (378) pupae 4d postWPP  (323) adult male 01day  (486) adult male 05day  (561) adult male 30day  (616) adult female 01day  (814) adult female 05day  (1230) adult female 30day  (1448) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3153) embryo 02-04hr  1488 embryo 04-06hr  (1909) embryo 06-08hr  (1632) embryo 08-10hr    1306 embryo 10-12hr    993 embryo 12-14hr    555 embryo 14-16hr    500 embryo 16-18hr    401 embryo 18-20hr    390 embryo 20-22hr    288 embryo 22-24hr    329 larva L1    554 larva L2    443 larva L3 12hr old    340 larva L3 puffstage 1-2    444 larva L3 puffstage 3-6    649 larva L3 puffstage 7-9    775 white prepupae new    782 white prepupae 12hr    963 white prepupae 24hr    885 pupae 2d postWPP    588 pupae 3d postWPP    378 pupae 4d postWPP    323 adult male 01day    486 adult male 05day    561 adult male 30day    616 adult female 01day    814 adult female 05day    1230 adult female 30day  1448 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3153 embryo 02-04hr    1488 embryo 04-06hr    1909 embryo 06-08hr    1632 embryo 08-10hr    1306 embryo 10-12hr    993 embryo 12-14hr    555 embryo 14-16hr    500 embryo 16-18hr    401 embryo 18-20hr    390 embryo 20-22hr    288 embryo 22-24hr    329 larva L1    554 larva L2    443 larva L3 12hr old    340 larva L3 puffstage 1-2    444 larva L3 puffstage 3-6    649 larva L3 puffstage 7-9    775 white prepupae new    782 white prepupae 12hr    963 white prepupae 24hr    885 pupae 2d postWPP    588 pupae 3d postWPP    378 pupae 4d postWPP    323 adult male 01day    486 adult male 05day    561 adult male 30day    616 adult female 01day    814 adult female 05day    1230 adult female 30day    1448 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3153 embryo 02-04hr    1488 embryo 04-06hr    1909 embryo 06-08hr    1632 embryo 08-10hr    1306 embryo 10-12hr    993 embryo 12-14hr    555 embryo 14-16hr    500 embryo 16-18hr    401 embryo 18-20hr    390 embryo 20-22hr    288 embryo 22-24hr    329 larva L1    554 larva L2    443 larva L3 12hr old    340 larva L3 puffstage 1-2    444 larva L3 puffstage 3-6    649 larva L3 puffstage 7-9    775 white prepupae new    782 white prepupae 12hr    963 white prepupae 24hr    885 pupae 2d postWPP    588 pupae 3d postWPP    378 pupae 4d postWPP    323 adult male 01day    486 adult male 05day    561 adult male 30day    616 adult female 01day    814 adult female 05day    1230 adult female 30day    1448 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0003479 expression level Developmental Stage   Expression Level embryo 00-02hr    3153 embryo 02-04hr    1488 embryo 04-06hr    1909 embryo 06-08hr    1632 embryo 08-10hr    1306 embryo 10-12hr    993 embryo 12-14hr    555 embryo 14-16hr    500 embryo 16-18hr    401 embryo 18-20hr    390 embryo 20-22hr    288 embryo 22-24hr    329 larva L1    554 larva L2    443 larva L3 12hr old    340 larva L3 puffstage 1-2    444 larva L3 puffstage 3-6    649 larva L3 puffstage 7-9    775 white prepupae new    782 white prepupae 12hr    963 white prepupae 24hr    885 pupae 2d postWPP    588 pupae 3d postWPP    378 pupae 4d postWPP    323 adult male 01day    486 adult male 05day    561 adult male 30day    616 adult female 01day    814 adult female 05day    1230 adult female 30day    1448 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3153) embryo 02-04hr  (1488) embryo 04-06hr  (1909) embryo 06-08hr  (1632) embryo 08-10hr  (1306) embryo 10-12hr  (993) embryo 12-14hr  (555) embryo 14-16hr  (500) embryo 16-18hr  (401) embryo 18-20hr  (390) embryo 20-22hr  (288) embryo 22-24hr  (329) larva L1  (554) larva L2  (443) larva L3 12hr old  (340) larva L3 puffstage 1-2  (444) larva L3 puffstage 3-6  (649) larva L3 puffstage 7-9  (775) white prepupae new  (782) white prepupae 12hr  (963) white prepupae 24hr  (885) pupae 2d postWPP  (588) pupae 3d postWPP  (378) pupae 4d postWPP  (323) adult male 01day  (486) adult male 05day  (561) adult male 30day  (616) adult female 01day  (814) adult female 05day  (1230) adult female 30day  (1448) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3153) embryo 02-04hr  1488 embryo 04-06hr  1909 embryo 06-08hr  1632 embryo 08-10hr    1306 embryo 10-12hr    993 embryo 12-14hr    555 embryo 14-16hr    500 embryo 16-18hr    401 embryo 18-20hr    390 embryo 20-22hr    288 embryo 22-24hr    329 larva L1    554 larva L2    443 larva L3 12hr old    340 larva L3 puffstage 1-2    444 larva L3 puffstage 3-6    649 larva L3 puffstage 7-9    775 white prepupae new    782 white prepupae 12hr    963 white prepupae 24hr    885 pupae 2d postWPP    588 pupae 3d postWPP    378 pupae 4d postWPP    323 adult male 01day    486 adult male 05day    561 adult male 30day    616 adult female 01day    814 adult female 05day    1230 adult female 30day  1448 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3153 embryo 02-04hr    1488 embryo 04-06hr    1909 embryo 06-08hr    1632 embryo 08-10hr    1306 embryo 10-12hr    993 embryo 12-14hr    555 embryo 14-16hr    500 embryo 16-18hr    401 embryo 18-20hr    390 embryo 20-22hr    288 embryo 22-24hr    329 larva L1    554 larva L2    443 larva L3 12hr old    340 larva L3 puffstage 1-2    444 larva L3 puffstage 3-6    649 larva L3 puffstage 7-9    775 white prepupae new    782 white prepupae 12hr    963 white prepupae 24hr    885 pupae 2d postWPP    588 pupae 3d postWPP    378 pupae 4d postWPP    323 adult male 01day    486 adult male 05day    561 adult male 30day    616 adult female 01day    814 adult female 05day    1230 adult female 30day    1448 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3153 embryo 02-04hr    1488 embryo 04-06hr    1909 embryo 06-08hr    1632 embryo 08-10hr    1306 embryo 10-12hr    993 embryo 12-14hr    555 embryo 14-16hr    500 embryo 16-18hr    401 embryo 18-20hr    390 embryo 20-22hr    288 embryo 22-24hr    329 larva L1    554 larva L2    443 larva L3 12hr old    340 larva L3 puffstage 1-2    444 larva L3 puffstage 3-6    649 larva L3 puffstage 7-9    775 white prepupae new    782 white prepupae 12hr    963 white prepupae 24hr    885 pupae 2d postWPP    588 pupae 3d postWPP    378 pupae 4d postWPP    323 adult male 01day    486 adult male 05day    561 adult male 30day    616 adult female 01day    814 adult female 05day    1230 adult female 30day    1448 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0003479    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0003479 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0003479 expression level Tissue   Expression Level Larval Central Nervous System    85.35 Larval Midgut    46.8 Larval Hindgut    56.3 Larval Malpighian Tubules    77.5 Larval Fat Body    55.9 Larval Salivary Gland no informative data Larval Trachea    73.725 Larval Carcass    44.275 Adult Head    36.7 Adult Eye    41.125 Adult Brain    40.7 Adult Thoracic-Abdominal Ganglion    52.4 Adult Crop    61.7 Adult Midgut    44.2 Adult Hindgut    46.4 Adult Malpighian Tubules    35.3 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    32.15 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    33.4 Adult Ovary    179.9 Adult Testis    59.9 Adult Male Accessory Gland    54.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    85.35 Larval Midgut    46.8 Larval Hindgut    56.3 Larval Malpighian Tubules    77.5 Larval Fat Body    55.9 Larval Salivary Gland no informative data Larval Trachea    73.725 Larval Carcass    44.275 Adult Head    36.7 Adult Eye    41.125 Adult Brain    40.7 Adult Thoracic-Abdominal Ganglion    52.4 Adult Crop    61.7 Adult Midgut    44.2 Adult Hindgut    46.4 Adult Malpighian Tubules    35.3 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    32.15 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    33.4 Adult Ovary    179.9 Adult Testis    59.9 Adult Male Accessory Gland    54.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    85.35 Larval Midgut    46.8 Larval Hindgut    56.3 Larval Malpighian Tubules    77.5 Larval Fat Body    55.9 Larval Salivary Gland no informative data Larval Trachea    73.725 Larval Carcass    44.275 Adult Head    36.7 Adult Eye    41.125 Adult Brain    40.7 Adult Thoracic-Abdominal Ganglion    52.4 Adult Crop    61.7 Adult Midgut    44.2 Adult Hindgut    46.4 Adult Malpighian Tubules    35.3 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    32.15 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    33.4 Adult Ovary    179.9 Adult Testis    59.9 Adult Male Accessory Gland    54.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    85.35 Larval Midgut    46.8 Larval Hindgut    56.3 Larval Malpighian Tubules    77.5 Larval Fat Body    55.9 Larval Salivary Gland no informative data Larval Trachea    73.725 Larval Carcass    44.275 Adult Head    36.7 Adult Eye    41.125 Adult Brain    40.7 Adult Thoracic-Abdominal Ganglion    52.4 Adult Crop    61.7 Adult Midgut    44.2 Adult Hindgut    46.4 Adult Malpighian Tubules    35.3 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    32.15 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    33.4 Adult Ovary    179.9 Adult Testis    59.9 Adult Male Accessory Gland    54.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0003479 expression level Tissue   Expression Level Larval Central Nervous System    85.35 Larval Midgut    46.8 Larval Hindgut    56.3 Larval Malpighian Tubules    77.5 Larval Fat Body    55.9 Larval Salivary Gland no informative data Larval Trachea    73.725 Larval Carcass    44.275 Adult Head    36.7 Adult Eye    41.125 Adult Brain    40.7 Adult Thoracic-Abdominal Ganglion    52.4 Adult Crop    61.7 Adult Midgut    44.2 Adult Hindgut    46.4 Adult Malpighian Tubules    35.3 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    32.15 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    33.4 Adult Ovary    179.9 Adult Testis    59.9 Adult Male Accessory Gland    54.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    85.35 Larval Midgut    46.8 Larval Hindgut    56.3 Larval Malpighian Tubules    77.5 Larval Fat Body    55.9 Larval Salivary Gland no informative data Larval Trachea    73.725 Larval Carcass    44.275 Adult Head    36.7 Adult Eye    41.125 Adult Brain    40.7 Adult Thoracic-Abdominal Ganglion    52.4 Adult Crop    61.7 Adult Midgut    44.2 Adult Hindgut    46.4 Adult Malpighian Tubules    35.3 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    32.15 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    33.4 Adult Ovary    179.9 Adult Testis    59.9 Adult Male Accessory Gland    54.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    85.35 Larval Midgut    46.8 Larval Hindgut    56.3 Larval Malpighian Tubules    77.5 Larval Fat Body    55.9 Larval Salivary Gland no informative data Larval Trachea    73.725 Larval Carcass    44.275 Adult Head    36.7 Adult Eye    41.125 Adult Brain    40.7 Adult Thoracic-Abdominal Ganglion    52.4 Adult Crop    61.7 Adult Midgut    44.2 Adult Hindgut    46.4 Adult Malpighian Tubules    35.3 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    32.15 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    33.4 Adult Ovary    179.9 Adult Testis    59.9 Adult Male Accessory Gland    54.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    85.35 Larval Midgut    46.8 Larval Hindgut    56.3 Larval Malpighian Tubules    77.5 Larval Fat Body    55.9 Larval Salivary Gland no informative data Larval Trachea    73.725 Larval Carcass    44.275 Adult Head    36.7 Adult Eye    41.125 Adult Brain    40.7 Adult Thoracic-Abdominal Ganglion    52.4 Adult Crop    61.7 Adult Midgut    44.2 Adult Hindgut    46.4 Adult Malpighian Tubules    35.3 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    32.15 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    33.4 Adult Ovary    179.9 Adult Testis    59.9 Adult Male Accessory Gland    54.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland no informative data Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    36.7   NA  Eye    41.125   NA  Brain    40.7   85.35  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    52.4   NA  Crop    61.7   46.8  Midgut    44.2   56.3  Hindgut    46.4   77.5  Malpighian Tubules    35.3   55.9  Fat Body    no informative data   no informative data  Salivary Gland    no informative data   NA  Heart    32.15   73.725  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    33.4   NA  Ovary    179.9   NA  Testis    59.9   NA  Male Accessory Gland    54.4   44.275  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_06
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003479 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7948-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | maternal effect spn-A1 lethal | pupal stage, with Scer\GAL4pnr-MD237 spn-AGD5050 viable (with Df(3R)X3F) spn-A1 spn-A001A spn-A2 spn-A3 spn-A009A spn-A009D spn-A010A spn-A032B spn-A048B spn-A050A spn-A055A spn-A061A spn-A068A spn-A084A spn-A087A spn-A091B spn-A091C spn-A093A spn-A095A spn-A104-7 spn-A116C spn-A119A spn-A128-53 spn-A148-15 spn-A155-52 Sterility Allele semi-fertile spn-A1 Other Phenotypes Allele DNA repair defective spn-A1 meiotic cell cycle defective | female (with Df(3R)X3F) spn-A093A radiation sensitive spn-A3 spn-A093A radiation sensitive (with Df(3R)X3F) spn-A093A radiation sensitive (with spn-A3) spn-A093A radiation sensitive (with spn-A048B) spn-A093A radiation sensitive (with spn-A093A) spn-A3 spn-A048B radiation sensitive | dominant spn-A1 Phenotype manifest in Allele chorion (with spn-A1) spn-A093A chorion (with spn-A093A) spn-A1 chorion | dorsal (with Df(3R)X3F) spn-A093A chorion | dorsal | germline clone spn-A155-52 dorsal appendage spn-A1 spn-Aunspecified dorsal appendage (with Df(3R)X3F) spn-A093A dorsal appendage | germline clone spn-A155-52 egg spn-A1 spn-Aunspecified egg | dorsal spn-A2 spn-A3 egg chamber spn-A3 germline cyst spn-A3 karyosome spn-A2 spn-A3 spn-Aunspecified karyosome (with Df(3R)X3F) spn-A093A karyosome | germline clone spn-A093A nurse cell spn-A2 spn-A3 oocyte spn-A2 spn-A3 presumptive oocyte spn-A1 synaptonemal complex spn-A3 synaptonemal complex (with Df(3R)X3F) spn-A093A
Classical Alleles ( 27 )
For All Classical Alleles Show
Allele of spn-A Class Mutagen Stocks Known lesion spn-A1 ethyl methanesulfonate 1 Yes spn-A001A ethyl methanesulfonate 0 Yes spn-A009A ethyl methanesulfonate 0 -- spn-A009D ethyl methanesulfonate 0 Yes spn-A010A ethyl methanesulfonate 0 Yes spn-A032B ethyl methanesulfonate 0 Yes spn-A048B ethyl methanesulfonate 0 Yes spn-A050A ethyl methanesulfonate 0 Yes spn-A055A ethyl methanesulfonate 0 Yes spn-A061A ethyl methanesulfonate 0 Yes spn-A068A ethyl methanesulfonate 0 Yes spn-A084A ethyl methanesulfonate 0 Yes spn-A087A ethyl methanesulfonate 0 Yes spn-A091B ethyl methanesulfonate 0 Yes spn-A091C ethyl methanesulfonate 0 Yes spn-A093A ethyl methanesulfonate 0 Yes spn-A095A ethyl methanesulfonate 0 Yes spn-A104-7 ethyl methanesulfonate 0 Yes spn-A116C ethyl methanesulfonate 0 Yes spn-A119A ethyl methanesulfonate 0 Yes spn-A128-53 ethyl methanesulfonate 0 Yes spn-A148-15 ethyl methanesulfonate 0 Yes spn-A155-52 ethyl methanesulfonate 0 Yes spn-A2 ethyl methanesulfonate 0 Yes spn-A3 ethyl methanesulfonate 0 Yes spn-A4 ethyl methanesulfonate 0 -- spn-Aunspecified 0 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of spn-A Class Mutagen Stocks Known lesion spn-AGD5050 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes spn-AJF01716 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)X3F (Staeva-Vieira et al., 2003, Cook, 2006.1.31)
Not disrupted in	Df(3R)01215 (Cook, 2006.1.31) Df(3R)tll-g (Cook, 2006.1.31)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD5050} NA P{TRiP.JF01716} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 17 unique terms )
Terms Based on Experimental Evidence ( 9 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cell cycle checkpoint inferred from mutant phenotype (Staeva-Vieira et al., 2003) double-strand break repair via synthesis-dependent strand annealing inferred from mutant phenotype (McVey et al., 2004, Wei and Rong, 2007) female meiosis inferred from mutant phenotype (Staeva-Vieira et al., 2003) germarium-derived oocyte fate determination inferred from genetic interaction with mus301 (Gonzalez-Reyes et al., 1997) intracellular mRNA localization inferred from mutant phenotype (Gonzalez-Reyes et al., 1997) karyosome formation inferred from mutant phenotype (Gonzalez-Reyes et al., 1997) oogenesis inferred from mutant phenotype (Gonzalez-Reyes et al., 1997) polarity specification of anterior/posterior axis inferred from mutant phenotype (Gonzalez-Reyes et al., 1997) polarity specification of dorsal/ventral axis inferred from mutant phenotype (Gonzalez-Reyes et al., 1997)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 10 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR011941, InterPro:IPR020587, InterPro:IPR020588 (FlyBase Curators et al., 2004-) damaged DNA binding inferred from electronic annotation with InterPro:IPR011941 (FlyBase Curators et al., 2004-) DNA-dependent ATPase activity inferred from electronic annotation with InterPro:IPR011941, InterPro:IPR020587, InterPro:IPR020588 (FlyBase Curators et al., 2004-) non-traceable author statement (Swiss-Prot Project Members, 1997.2.1) recombinase activity inferred from sequence or structural similarity with human RAD51 (Sekelsky et al., 2000)
Biological Process
CV term Evidence References
DNA recombination inferred from sequence or structural similarity with human RAD51 (Sekelsky et al., 2000) DNA repair inferred from sequence or structural similarity (Swiss-Prot Project Members, 1997.2.1) inferred from sequence or structural similarity with human RAD51 (Sekelsky et al., 2000) inferred from sequence or structural similarity with Saccharomyces RAD51 (FlyBase, 1992-) intracellular mRNA localization traceable author statement (Cooperstock and Lipshitz, 1997) oocyte differentiation non-traceable author statement (Deng and Lin, 2001) oogenesis traceable author statement (van Eeden and St. Johnston, 1999)
Cellular Component
CV term Evidence References
nucleus non-traceable author statement (Swiss-Prot Project Members, 1997.2.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions spn-A allele Gene References spn-A3 Lig4 (McVey et al., 2004) spn-D (Gonzalez-Reyes et al., 1997, Huynh and St. Johnston, 2000) spn-E (Gonzalez-Reyes et al., 1997) spn-A093A Lig4 (McVey et al., 2004) mei-W68 (Staeva-Vieira et al., 2003) unspecified lok (Staeva-Vieira et al., 2003)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68433 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0003479 DroID - A comprehensive database of gene and protein interactions. • FBgn0003479 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43577
Orthologs
Genome-wide drosophilid orthologs	Dana\GF16205 Dere\GG11967 Dgri\GH18396 Dmoj\GI23388 Dper\GL13479 Dpse\GA20711 Dsec\GM12184 Dsim\GD17366 Dvir\GJ10382 Dwil\GK13420 Dyak\GE23416
Curated drosophilid orthologs	Dpse\GA20711   Dsim\spn-A (Anderson et al., 2009)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL006080-PA Aedes aegypti (mosquito) XP_624827.2 Apis mellifera (honey bee) XP_001948893.1 Acyrthosiphon pisum (pea aphid) At5g20850.1 Arabidopsis thaliana (wall cress) 85216 Batrachochytrium dendrobatidis (chytrid fungus) XP_001897076.1 Brugia malayi (roundworm nematode) BGIBMGA005107-PA Bombyx mori (silk worm) ENSBTAP00000003788 Bos taurus (bovine) CAL0001214 Candida albicans (a form of yeast) CN24161 Caenorhabditis brenneri (small nematode) CN27621 Caenorhabditis brenneri (small nematode) CBP27132 Caenorhabditis briggsae (nematode) CE29064 Caenorhabditis elegans (worm) ENSCAFP00000013557 Canis familiaris (dog) CAGL0I05544g Candida glabrata (haploid yeast) Chro.50352 Cryptosporidium hominis (obligate parasite) JA10714 Caenorhabditis japonica (nematode) CMR053C Cyanidioschyzon merolae (red alga) cn01690 Cryptococcus neoformans (yeast-like fungus) cgd5_410 Cryptosporidium parvum (protozoan parasite) CPIJ003679 Culex pipens (mosquito) ENSCPOP00000012705 Cavia porcellus (guinea pig) RP34187 Caenorhabditis remanei (nematode) RP35674 Caenorhabditis remanei (nematode) ENSCSAVP00000002327 Ciona savignyi (sedentary tunicate) DDB0217219 Dictyostelium discoideum (amoeba) DDB0232316 Dictyostelium discoideum (amoeba) DEHA2C16698g Debaryomyces Hansenii (yeast) 299714 Daphnia pulex (daphnia) ENSDARP00000060705 Danio rerio (zebra fish) ENSECAP00000015324 Equus caballus (horse) XP_654076 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000016197 Gymnopilus aculeatus (mushroom) ENSGALP00000032107 Gallus gallus (chicken) GL50803_13346 Giardia lamblia (flagellated protozoan) ENSP00000372088 Homo sapiens (human) ISCW001553-PA Ixodes scapularis (deer tick) KLLA0E20241g Kluyveromyces lactis (yeast) 159984 Lottia gigantea (owl limpet) LmjF28.0550 Leishmania major (virus) ENSMODP00000000325 Monodelphis domestica (gray opossum) ENSMMUP00000033829 Macaca mulatta (rhesus monkey) ENSMUSP00000028795 Mus musculus (house mouse) XP_001601790.1 Nasonia vitripennis (wasp) ENSOANP00000016750 Ornithorynchus anatinus (platypus) ENSORLP00000022299 Oryzias latipes (japanese killifish) LOC_Os11g40150.1 Oryza sativa (asian rice) 18636 Ostreococcus tauri (green alga) PF11_0087 Plasmodium falciparum (protozoal parasite) PHUM001090-PA Pediculus humanus (human body louse) PP09869 Pristionchus pacificus (nematode) 137435 Physcomitrella patens (moss) ENSPPYP00000007198 Pongo pygmaeus (orangutan) 74160 Phytophthora ramorum (sudden oak death pathogen) 108595 Phytophthora sojae (root rot pathogen) 589354 Populus trichocarpa (black cottonwood) ENSPTRP00000051614 Pan troglodytes (chimpanzee) PVX_091045 Plasmodium vivax (protozoal parasite) ENSRNOP00000053270 Rattus norvegicus (norway rat) YER095W Saccharomyces cerevisiae (budding yeast) Smp_124230 Schistosoma mansoni (trematode parasite) SPAC644.14c Schizosaccharomyces pombe (fission yeast) XP_001181485.1 Strongylocentrotus purpuratus (purple sea urchin) 52181 Trichoplax adhaerens (metazoa) TA07350 Theileria annulata (apicomplexan parasite) XP_974146.1 Tribolium castaneum (red flour beetle) XP_974640.1 Tribolium castaneum (red flour beetle) Tc00.1047053503801.30 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053508817.50 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000022389 Tetraodon nigroviridis (green spotted pufferfish) TP04_0230 Theileria parva (parasitic protozoan) ENSTRUP00000010366 Takifugu rubripes (pufferfish Takifugu) 3702.m00060 Tetrahymena thermophila (ciliate protozoa) 87076.m00035 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000034829 Xenopus tropicalis (frog) YALI0F15477g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB18284 NV15439 LH19187 ISCW001553 FBgn0240605 FBgn0215429 FBgn0197666 FBgn0188925 FBgn0167124 JGI_V11_299714 FBgn0080702 FBgn0151085 FBgn0146114 FBgn0125864 FBgn0104262 FBgn0093227 CPIJ003679 BGIBMGA005107 ACYPI008482 GB17143 AGAP013412 AAEL006080 PHUM458200 GLEAN_07816 GLEAN_07805
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	31199 y1 v1; P{TRiP.JF01716}attP2/TM3, Sb1 3322 Dp(1;Y)BS; ru1 st1 e1 spn-A1 ca1/TM3, Sb1
VDRC	v13362 w1118 P{GD5050}v13362 v14021 w1118; P{GD5050}v14021/TM3
Genomic Clones ( 2 )
	BACR05L15 BACR07A18 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 16 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE29170 RH24133
Other clones	DPiM_RE29170
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD33913 LP03360 LP16118 LP17075 RH24470 SD11494 SD18854
Other clones	47199 EK175437 FGH001G04 LD35801 LD44962 UUGC0312
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0003479 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43577
Antibody Information
	polyclonal (Chiolo et al., 2011)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	Analysis of mutants of the 5 spindle genes (spn-A, spn-B, mus301, spn-D and spn-E) reveals that the group of genes is required for each of the symmetry-breaking steps that generate polarity during axis formation. spn-E is required for the localisation of fs(1)K10, bcd and osk mRNAs, spn-A. spn-B, mus301 and spn-D play an indirect role in this process. (Gonzalez-Reyes et al., 1997) Isolation and preliminary molecular analysis of spn-A. (McKee et al., 1996) spn-A has been cloned and sequenced. (Akaboshi et al., 1994) Mutations in the spn-A, spn-B and spn-D genes result in a very similar phenotype to those in mus301, and in all cases the misplacement of the oocyte has the same consequences on the establishment of AP polarity in the egg chamber, as determined by the slbo expression in the follicle cells and the localization of osk and bcd mRNAs within the oocyte. (Gonzalez-Reyes and St. Johnston, 1994)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079844 NM_170463 RefSeq (Proteins) • NP_524583 NP_733342 DDBJ / EMBL / GenBank • AAA64873 AAF57005 AAN14213 AAN71546 AI512877 BAA04580 BAA07039 BI584842 BT001791 D17726 D37788 L41342 Entrez Gene - A searchable database of RefSeq genes. • 43577 UniProtKB/Swiss-Prot • Q27297
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • ATPase, AAA+ type, core (IPR003593) DNA repair Rad51/transcription factor NusA, alpha-helical (IPR010995) DNA recombination/repair protein Rad51 (IPR011941) DNA recombination and repair protein Rad51, C-terminal (IPR013632) Helix-hairpin-helix DNA-binding motif, class 1 (IPR003583) DNA recombination and repair protein, RecA-like (IPR016467) DNA recombination/repair protein RecA, monomer-monomer interface (IPR020587) DNA recombination/repair protein RecA/RadB, ATP-binding domain (IPR020588)
Linkouts
	BioGRID - A database of protein and genetic interactions • 68433 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0003479 DroID - A comprehensive database of gene and protein interactions. • FBgn0003479 DRSC - Results from RNAi screens. • FBgn0003479 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003479 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7948-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0003479 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43577 InParanoid A subset of ortholog calls from InParanoid. • AAEL006080-PA Aedes aegypti (mosquito) XP_624827.2 Apis mellifera (honey bee) XP_001948893.1 Acyrthosiphon pisum (pea aphid) At5g20850.1 Arabidopsis thaliana (wall cress) 85216 Batrachochytrium dendrobatidis (chytrid fungus) XP_001897076.1 Brugia malayi (roundworm nematode) BGIBMGA005107-PA Bombyx mori (silk worm) ENSBTAP00000003788 Bos taurus (bovine) CAL0001214 Candida albicans (a form of yeast) CN24161 Caenorhabditis brenneri (small nematode) CN27621 Caenorhabditis brenneri (small nematode) CBP27132 Caenorhabditis briggsae (nematode) CE29064 Caenorhabditis elegans (worm) ENSCAFP00000013557 Canis familiaris (dog) CAGL0I05544g Candida glabrata (haploid yeast) Chro.50352 Cryptosporidium hominis (obligate parasite) JA10714 Caenorhabditis japonica (nematode) CMR053C Cyanidioschyzon merolae (red alga) cn01690 Cryptococcus neoformans (yeast-like fungus) cgd5_410 Cryptosporidium parvum (protozoan parasite) CPIJ003679 Culex pipens (mosquito) ENSCPOP00000012705 Cavia porcellus (guinea pig) RP34187 Caenorhabditis remanei (nematode) RP35674 Caenorhabditis remanei (nematode) ENSCSAVP00000002327 Ciona savignyi (sedentary tunicate) DDB0217219 Dictyostelium discoideum (amoeba) DDB0232316 Dictyostelium discoideum (amoeba) DEHA2C16698g Debaryomyces Hansenii (yeast) 299714 Daphnia pulex (daphnia) ENSDARP00000060705 Danio rerio (zebra fish) ENSECAP00000015324 Equus caballus (horse) XP_654076 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000016197 Gymnopilus aculeatus (mushroom) ENSGALP00000032107 Gallus gallus (chicken) GL50803_13346 Giardia lamblia (flagellated protozoan) ENSP00000372088 Homo sapiens (human) ISCW001553-PA Ixodes scapularis (deer tick) KLLA0E20241g Kluyveromyces lactis (yeast) 159984 Lottia gigantea (owl limpet) LmjF28.0550 Leishmania major (virus) ENSMODP00000000325 Monodelphis domestica (gray opossum) ENSMMUP00000033829 Macaca mulatta (rhesus monkey) ENSMUSP00000028795 Mus musculus (house mouse) XP_001601790.1 Nasonia vitripennis (wasp) ENSOANP00000016750 Ornithorynchus anatinus (platypus) ENSORLP00000022299 Oryzias latipes (japanese killifish) LOC_Os11g40150.1 Oryza sativa (asian rice) 18636 Ostreococcus tauri (green alga) PF11_0087 Plasmodium falciparum (protozoal parasite) PHUM001090-PA Pediculus humanus (human body louse) PP09869 Pristionchus pacificus (nematode) 137435 Physcomitrella patens (moss) ENSPPYP00000007198 Pongo pygmaeus (orangutan) 74160 Phytophthora ramorum (sudden oak death pathogen) 108595 Phytophthora sojae (root rot pathogen) 589354 Populus trichocarpa (black cottonwood) ENSPTRP00000051614 Pan troglodytes (chimpanzee) PVX_091045 Plasmodium vivax (protozoal parasite) ENSRNOP00000053270 Rattus norvegicus (norway rat) YER095W Saccharomyces cerevisiae (budding yeast) Smp_124230 Schistosoma mansoni (trematode parasite) SPAC644.14c Schizosaccharomyces pombe (fission yeast) XP_001181485.1 Strongylocentrotus purpuratus (purple sea urchin) 52181 Trichoplax adhaerens (metazoa) TA07350 Theileria annulata (apicomplexan parasite) XP_974146.1 Tribolium castaneum (red flour beetle) XP_974640.1 Tribolium castaneum (red flour beetle) Tc00.1047053503801.30 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053508817.50 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000022389 Tetraodon nigroviridis (green spotted pufferfish) TP04_0230 Theileria parva (parasitic protozoan) ENSTRUP00000010366 Takifugu rubripes (pufferfish Takifugu) 3702.m00060 Tetrahymena thermophila (ciliate protozoa) 87076.m00035 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000034829 Xenopus tropicalis (frog) YALI0F15477g Yarrowia lipolytica (nonconventional yeast) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /sturtevant/rad51spina1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43577 modMine - Data generated by the modENCODE project. • FBgn0003479 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB18284 NV15439 LH19187 ISCW001553 FBgn0240605 FBgn0215429 FBgn0197666 FBgn0188925 FBgn0167124 JGI_V11_299714 FBgn0080702 FBgn0151085 FBgn0146114 FBgn0125864 FBgn0104262 FBgn0093227 CPIJ003679 BGIBMGA005107 ACYPI008482 GB17143 AGAP013412 AAEL006080 PHUM458200 GLEAN_07816 GLEAN_07805
Synonyms & Secondary IDs ( 23 )
Reported As
Symbol Synonym	CG7948 (Jin et al., 2001, Ni et al., 2008) D37788 (Ptak and Petrov, 2002) DMR (Akaboshi, 1995, Kawasaki et al., 1996) DMR1 (Akaboshi et al., 1994) DMR/DroRAD51 (Kawasaki et al., 1998) DmRad51 (McVey et al., 2004, Pastink and Lohman, 1999) dmRAD51 (Staeva-Vieira et al., 2003) Dm Rad51 (Abdu et al., 2003) DmRAD51 (Staeva-Vieira et al., 2003, Vieira and Lehmann, 2002) Dmrad51 (Morris and Lehmann, 1999) RA51 (Brocchieri and Karlin, 1998) RA51_DROME (Storm and Sonnhammer, 2003) Rad51 (Ghabrial et al., 1998, Villeneuve and Hillers, 2001, Sekelsky et al., 2000, Gene Ontology Consortium, 2000, Brendel et al., 1997, Alexiadis et al., 2004, Alexiadis and Kadonaga, 2002, Bozas and Carroll, 2006, Pawlowski and Cande, 2005, Holmes et al., 2006, Yoo and McKee, 2004, Wei and Rong, 2007, Johnson-Schlitz and Engels, 2006, Bozas et al., 2009, Chan et al., 2010) RAD51 (McVey et al., 2003, McKee, 1995, Thacker, 1999) rad51 (Yu and McVey, 2010, Johnson-Schlitz et al., 2007, Klovstad et al., 2008) Rad51dm (McKee et al., 1996) spnA (McVey et al., 2004, Johnstone and Lasko, 2001, Huynh and St. Johnston, 2000, Morris et al., 2000, Ghabrial et al., 1998, Bozas and Carroll, 2006, Holmes et al., 2006, Hochwagen, 2006, Yu and McVey, 2010, Yoo, 2006, Wei and Rong, 2007, Klovstad et al., 2008, Navarro et al., 2009, Bozas et al., 2009, Johnson-Schlitz and Engels, 2006, Johnson-Schlitz et al., 2007, Lancaster et al., 2010) spn-A (Mukai et al., 2006, LaRocque et al., 2007, Blanton et al., 2005, McCaffrey et al., 2006, Barbosa et al., 2007, Trowbridge et al., 2007, Joyce and McKim, 2009, Anderson et al., 2009, Andersen et al., 2009, Chan et al., 2010, Reis et al., 2011, Andersen et al., 2011) Spn-A (Dworkin et al., 2009)
Name Synonym	Rad51-like   Spindle-A (Berg, 2005) spindle A (Mukai et al., 2006) spindle-A (Yoo, 2006)
Secondary FlyBase IDs
	FBgn0011700
References ( 90 )
Generate a list of	All references relating to this gene ( 90 )
List References by type	Research paper  ( 48 ) Supplementary material  ( 3 ) Review  ( 13 ) Personal communication to FlyBase  ( 4 ) Abstract  ( 12 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 2 ) Stock list  ( 1 ) Protein sequence record  ( 1 ) Book  ( 1 ) Computer file  ( 1 ) Curated genome annotation  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 6 )
	Andersen et al., 2011, PLoS Genet. 7(10): e1002315 Three Structure-Selective Endonucleases Are Essential in the Absence of BLM Helicase in Drosophila. [FBrf0216460] Chiolo et al., 2011, Cell 144(5): 732--744 Double-Strand Breaks in Heterochromatin Move Outside of a Dynamic HP1a Domain to Complete Recombinational Repair. [FBrf0213146] Reis et al., 2011, PLoS ONE 6(3): e17512 Drosophila Genes That Affect Meiosis Duration Are among the Meiosis Related Genes That Are More Often Found Duplicated. [FBrf0213266] Chan et al., 2010, PLoS Genet. 6: e1001005 Dual roles for DNA polymerase theta in alternative end-joining repair of double-strand breaks in Drosophila. [FBrf0211220] Lancaster et al., 2010, PLoS Genet. 6(10): e1001179 The Meiotic Recombination Checkpoint Suppresses NHK-1 Kinase to Prevent Reorganisation of the Oocyte Nucleus in Drosophila. [FBrf0212208] Yu and McVey, 2010, Nucleic Acids Res. 38(17): 5706--5717 Synthesis-dependent microhomology-mediated end joining accounts for multiple types of repair junctions. [FBrf0211874] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...