transcription factor - zinc finger - involved muscle development - induces the fate of tendon cells in the embryo as well as in the adult fly - works upstream of tendon specific genes including Thrombospondin, the Efg-like domain protein Slowdown and Leucine-rich tendon-specific protein.
Stop-codon suppression (UAG) postulated; FBrf0216884.
Gene model reviewed during 5.44
Gene model reviewed during 5.54
Low-frequency RNA-Seq exon junction(s) not annotated.
1180, 906 (aa)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\sr using the Feature Mapper tool.
sr is expressed in columns 2 and 5 in the prospective denticle field and in one additional column in the smooth field.
GBrowse - Visual display of RNA-Seq signalsView Dmel\sr in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.
sr is necessary and sufficient to initiate the developmental program of epidermal muscle attachment cells.
sr activity controls the expression of epidermal muscle attachment site-specific target genes in cells of ectodermal but not mesodermal origin. sr-expressing ectodermal cells generate long-range signals that interfere with the spatial orientation of elongating myotubes.
Cloning and molecular characterisation of sr reveals that sr activity induces a subset of ectodermal cells to develop into muscle attachment sites and to provide spatial cues necessary to orient myotubes along the basal surface of the epidermis to their targeted attachment cells.
sr gene product is required for apodeme development or muscle/apodeme attachment.
sr is expressed in the ectoderm at the future muscle attachment sites and may be required for apodeme differentiation to enable the correct targeting by the approaching myotubule.
Mutants in sr specifically affect the dorsolateral muscles.
Mutant individuals display a dark median stripe on the thorax.