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Gene Dmel\sr

General Information
Symbol	Dmel\sr	Species	D. melanogaster
Name	stripe	Annotation symbol	CG7847
Feature type	protein_coding_gene	FlyBase ID	FBgn0003499
Gene Model Status	Current	Stock availability	216 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map	3-62.0
Cytogenetic map	90E4-90F1	Sequence location	3R:13,916,525..13,959,471 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene stripe is referred to in FlyBase by the symbol Dmel\sr (CG7847, FBgn0003499). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: zinc ion binding; nucleic acid binding. There is experimental evidence that it is involved in the biological process: central nervous system development; ectoderm development; somatic muscle development; germ-band shortening; muscle organ development; epithelial cell migration, open tracheal system; phagocytosis, engulfment. 63 alleles are reported. The phenotypes of these alleles are annotated with: organ system; multicellular structure; portion of tissue; organ system subdivision; tracheal system; extended germ band embryo; adult; adult segment; region of integument; skeletal muscle of abdomen. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Zinc finger C2H2-type/integrase DNA-binding domain; Zinc finger, C2H2; Zinc finger, C2H2-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed within 12-18 embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult brain. Comments on Affy2 ProbeSet: ProbeSet 1639223_a_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of sr. Gene sequence location is 3R:13916525..13959471.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	sr: stripe Trident pattern on thorax replaced by broad light gray stripe at 25; stripe is dark at 18 or in the presence of heterozygous or homozygous b or e. Homozygotes are flightless (Levine and Wyman, 1973, Proc. Nat. Acad. Sci. USA 70: 1050-54) and show a reduction in size of a specific indirect flight muscle, the dorsal longitudinal muscle (DLM). The DLM is absent from sr/Df(3)sr adults. Early development of the indirect flight muscles is normal, but in the thirty-five-hour pupa the DLM begins to degenerate leading to its absence in adults (Costello and Wyman).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 90E4-90F1   Limits computationally determined from genome sequence between P{EP}cpoEP3679 and P{EP}Dlc90FEP3634
Experimentally Determined Cytological Location
Cytogenetic map Notes References 90E1-90E2   (determined by in situ hybridisation)   (Spradling et al., 1999) 90E1-90E4   (determined by in situ hybridisation)   (Bellen and Kolodkin, 1993) 90E1-90E2   (determined by in situ hybridisation)   (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location	3-62.0
Left of (cM)
Right of (cM)	r(αGPDH) (King and McDonald, 1982)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\sr for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	gene_with_stop_codon_read_through ; SO:0000697 Stop-codon suppression (UAG) postulated; FBrf0216884. Gene model reviewed during 5.44
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) sr-RA FBtr0083542  NM_079671   5757   1186 sr-RB FBtr0083543  NM_169786   4538   906 sr-RC FBtr0301615  NM_001170172   3971   717 sr-RD FBtr0330050  NM_001275764   5757   1271
Additional Transcript Data & Comments
Reported size (kB)	6.5, 5.0 (northern blot) (Lee et al., 1995) 5.8, 4.5 (compiled cDNA) (Frommer et al., 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein sr-PA   FBpp0082966   128.3   1186   7.65     NP_524395   AAF55492 sr-PB   FBpp0082967   99.0   906   8.06     NP_732289   AAN13756 sr-PC   FBpp0290830   76.6   717   7.92     NP_001163643   ACZ94939 sr-PD   FBpp0303083   137.5   1271   7.34     NP_001262693   AGB96073
Additional Polypeptide Data & Comments
Reported size (kDa)	1180, 906 (aa) (Frommer et al., 1996)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger C2H2-type/integrase DNA-binding domain (IPR013087) Zinc finger, C2H2-like (IPR015880) Zinc finger, C2H2 (IPR007087)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF55492   AE014297 AAN13756   AE014297 ACZ94939   AE014297 AGB96073   BI371195   BI621736   BT015207   BT133222   CO339989   CZ472469   CZ472747   CZ472788   CZ473037   CZ474916   CZ474917   CZ476049   CZ476239   CZ476588   CZ476589   CZ485053   CZ488640   CZ488641   CZ488662   EC255783   G00573   GH860127   GH904228   S79891 AAB35453   U42402 AAB02354   U42403 AAB02355
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8IN91 Q9VED3 E1JIP0 Q26452 Q24163 Q7JP26
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   muscle attachment site   (Frommer et al., 1996) epidermis | restricted   (Frommer et al., 1996) embryonic stage 14 -- 17   muscle attachment site   (Lee et al., 1995) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage & pupal stage     (Lee et al., 1995)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage   muscle attachment site   (Frommer et al., 1996) epidermis | restricted   (Frommer et al., 1996) embryonic stage 13 -- 16   lch5 cap attachment cell   (Inbal et al., 2004) embryonic stage 15   muscle attachment site   (Piepenburg et al., 2000) muscle attachment site of segment border muscle   (Piepenburg et al., 2000) embryonic stage 16   lch5 ligament attachment cell   (Inbal et al., 2004) scolopidial ligament cell | subset   (Inbal et al., 2004)
Additional Descriptive Data
	sr protein expression is restricted to the nuclei of epidermal cells and is seen at muscle attachment sites. No expression is observed in muscles or muscle precursors. The antibodies used recognize both forms of sr protein. (Frommer et al., 1996) sr protein expression is restricted to the nuclei of epidermal cells and is seen at muscle attachment sites. No expression is observed in muscles or muscle precursors. The antibodies used recognize both forms of sr protein. (Frommer et al., 1996)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
Reporter: P{GawB}srmd710 Stage Tissue/Position (including subcellular localization) Reference embryonic stage   tendon cell   (Swan et al., 2004) chordotonal organ | subset   (Inbal et al., 2004) lch5 cap attachment cell   (Inbal et al., 2004) embryonic stage 16   scolopidial ligament cell | subset   (Inbal et al., 2004) first instar larval stage -- second instar larval stage   tendon cell   (Subramanian et al., 2003) third instar larval stage   wing disc | restricted   (Usui et al., 2004) scutum | presumptive   (Usui et al., 2004) pupal stage   mesothoracic tergum | restricted   (Usui et al., 2004) pupal stage P6 -- pharate adult stage P15   tendon cell   (Ghazi et al., 2000) Comment:reference states >=26 hr APF
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult brain. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    14.675 Larval Midgut    4.5 Larval Hindgut    13.4 Larval Malpighian Tubules    3 Larval Fat Body    1.9 Larval Salivary Gland    3.7 Larval Trachea    3.3 Larval Carcass    99.25 Adult Head    38.4 Adult Eye    6.975 Adult Brain    124.9 Adult Thoracic-Abdominal Ganglion    81.7 Adult Crop    68.9 Adult Midgut    6.3 Adult Hindgut    16 Adult Malpighian Tubules    2.5 Adult Fat Body    11.5 Adult Salivary Gland    5.1 Adult Heart    10.15 Adult VirginFemale Spermatheca    9.2 Adult InseminatedFemale Spermatheca    10.2 Adult Ovary    0.8 Adult Testis    2.3 Adult Male Accessory Gland    3.7 Adult Carcass    26.8 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    14.675 Larval Midgut    4.5 Larval Hindgut    13.4 Larval Malpighian Tubules    3 Larval Fat Body    1.9 Larval Salivary Gland    3.7 Larval Trachea    3.3 Larval Carcass    99.25 Adult Head    38.4 Adult Eye    6.975 Adult Brain    124.9 Adult Thoracic-Abdominal Ganglion    81.7 Adult Crop    68.9 Adult Midgut    6.3 Adult Hindgut    16 Adult Malpighian Tubules    2.5 Adult Fat Body    11.5 Adult Salivary Gland    5.1 Adult Heart    10.15 Adult VirginFemale Spermatheca    9.2 Adult InseminatedFemale Spermatheca    10.2 Adult Ovary    0.8 Adult Testis    2.3 Adult Male Accessory Gland    3.7 Adult Carcass    26.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    14.675 Larval Midgut    4.5 Larval Hindgut    13.4 Larval Malpighian Tubules    3 Larval Fat Body    1.9 Larval Salivary Gland    3.7 Larval Trachea    3.3 Larval Carcass    99.25 Adult Head    38.4 Adult Eye    6.975 Adult Brain    124.9 Adult Thoracic-Abdominal Ganglion    81.7 Adult Crop    68.9 Adult Midgut    6.3 Adult Hindgut    16 Adult Malpighian Tubules    2.5 Adult Fat Body    11.5 Adult Salivary Gland    5.1 Adult Heart    10.15 Adult VirginFemale Spermatheca    9.2 Adult InseminatedFemale Spermatheca    10.2 Adult Ovary    0.8 Adult Testis    2.3 Adult Male Accessory Gland    3.7 Adult Carcass    26.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    14.675 Larval Midgut    4.5 Larval Hindgut    13.4 Larval Malpighian Tubules    3 Larval Fat Body    1.9 Larval Salivary Gland    3.7 Larval Trachea    3.3 Larval Carcass    99.25 Adult Head    38.4 Adult Eye    6.975 Adult Brain    124.9 Adult Thoracic-Abdominal Ganglion    81.7 Adult Crop    68.9 Adult Midgut    6.3 Adult Hindgut    16 Adult Malpighian Tubules    2.5 Adult Fat Body    11.5 Adult Salivary Gland    5.1 Adult Heart    10.15 Adult VirginFemale Spermatheca    9.2 Adult InseminatedFemale Spermatheca    10.2 Adult Ovary    0.8 Adult Testis    2.3 Adult Male Accessory Gland    3.7 Adult Carcass    26.8 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    14.675 Larval Midgut    4.5 Larval Hindgut    13.4 Larval Malpighian Tubules    3 Larval Fat Body    1.9 Larval Salivary Gland    3.7 Larval Trachea    3.3 Larval Carcass    99.25 Adult Head    38.4 Adult Eye    6.975 Adult Brain    124.9 Adult Thoracic-Abdominal Ganglion    81.7 Adult Crop    68.9 Adult Midgut    6.3 Adult Hindgut    16 Adult Malpighian Tubules    2.5 Adult Fat Body    11.5 Adult Salivary Gland    5.1 Adult Heart    10.15 Adult VirginFemale Spermatheca    9.2 Adult InseminatedFemale Spermatheca    10.2 Adult Ovary    0.8 Adult Testis    2.3 Adult Male Accessory Gland    3.7 Adult Carcass    26.8 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    14.675 Larval Midgut    4.5 Larval Hindgut    13.4 Larval Malpighian Tubules    3 Larval Fat Body    1.9 Larval Salivary Gland    3.7 Larval Trachea    3.3 Larval Carcass    99.25 Adult Head    38.4 Adult Eye    6.975 Adult Brain    124.9 Adult Thoracic-Abdominal Ganglion    81.7 Adult Crop    68.9 Adult Midgut    6.3 Adult Hindgut    16 Adult Malpighian Tubules    2.5 Adult Fat Body    11.5 Adult Salivary Gland    5.1 Adult Heart    10.15 Adult VirginFemale Spermatheca    9.2 Adult InseminatedFemale Spermatheca    10.2 Adult Ovary    0.8 Adult Testis    2.3 Adult Male Accessory Gland    3.7 Adult Carcass    26.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    14.675 Larval Midgut    4.5 Larval Hindgut    13.4 Larval Malpighian Tubules    3 Larval Fat Body    1.9 Larval Salivary Gland    3.7 Larval Trachea    3.3 Larval Carcass    99.25 Adult Head    38.4 Adult Eye    6.975 Adult Brain    124.9 Adult Thoracic-Abdominal Ganglion    81.7 Adult Crop    68.9 Adult Midgut    6.3 Adult Hindgut    16 Adult Malpighian Tubules    2.5 Adult Fat Body    11.5 Adult Salivary Gland    5.1 Adult Heart    10.15 Adult VirginFemale Spermatheca    9.2 Adult InseminatedFemale Spermatheca    10.2 Adult Ovary    0.8 Adult Testis    2.3 Adult Male Accessory Gland    3.7 Adult Carcass    26.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    14.675 Larval Midgut    4.5 Larval Hindgut    13.4 Larval Malpighian Tubules    3 Larval Fat Body    1.9 Larval Salivary Gland    3.7 Larval Trachea    3.3 Larval Carcass    99.25 Adult Head    38.4 Adult Eye    6.975 Adult Brain    124.9 Adult Thoracic-Abdominal Ganglion    81.7 Adult Crop    68.9 Adult Midgut    6.3 Adult Hindgut    16 Adult Malpighian Tubules    2.5 Adult Fat Body    11.5 Adult Salivary Gland    5.1 Adult Heart    10.15 Adult VirginFemale Spermatheca    9.2 Adult InseminatedFemale Spermatheca    10.2 Adult Ovary    0.8 Adult Testis    2.3 Adult Male Accessory Gland    3.7 Adult Carcass    26.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    38.4   NA  Eye    6.975   NA  Brain    124.9   14.675  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    81.7   NA  Crop    68.9   4.5  Midgut    6.3   13.4  Hindgut    16   3  Malpighian Tubules    2.5   1.9  Fat Body    no informative data   3.7  Salivary Gland    5.1   NA  Heart    10.15   3.3  Trachea    NA   NA  VirginFemale Spermatheca    9.2   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    0.8   NA  Testis    2.3   NA  Male Accessory Gland    3.7   99.25  Carcass    no informative data FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    2 central nervous system, pupae P8    3 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    3 head, mated 1-day female    7 head, mated 4-day female    5 head, mated 20-day female    2 head, mated 1-day male    10 head, mated 4-day male    5 head, mated 20-day male    5 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    3 carcass, larvae L3 wandering    5 carcass, 1-day adult    5 carcass, 4-day adult    5 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    2 central nervous system, pupae P8    3 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    3 head, mated 1-day female    7 head, mated 4-day female    5 head, mated 20-day female    2 head, mated 1-day male    10 head, mated 4-day male    5 head, mated 20-day male    5 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    3 carcass, larvae L3 wandering    5 carcass, 1-day adult    5 carcass, 4-day adult    5 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    2 central nervous system, pupae P8    3 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    3 head, mated 1-day female    7 head, mated 4-day female    5 head, mated 20-day female    2 head, mated 1-day male    10 head, mated 4-day male    5 head, mated 20-day male    5 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    3 carcass, larvae L3 wandering    5 carcass, 1-day adult    5 carcass, 4-day adult    5 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    2 central nervous system, pupae P8    3 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    3 head, mated 1-day female    7 head, mated 4-day female    5 head, mated 20-day female    2 head, mated 1-day male    10 head, mated 4-day male    5 head, mated 20-day male    5 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    3 carcass, larvae L3 wandering    5 carcass, 1-day adult    5 carcass, 4-day adult    5 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    2 central nervous system, pupae P8    3 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    3 head, mated 1-day female    7 head, mated 4-day female    5 head, mated 20-day female    2 head, mated 1-day male    10 head, mated 4-day male    5 head, mated 20-day male    5 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    3 carcass, larvae L3 wandering    5 carcass, 1-day adult    5 carcass, 4-day adult    5 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    2 central nervous system, pupae P8    3 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    3 head, mated 1-day female    7 head, mated 4-day female    5 head, mated 20-day female    2 head, mated 1-day male    10 head, mated 4-day male    5 head, mated 20-day male    5 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    3 carcass, larvae L3 wandering    5 carcass, 1-day adult    5 carcass, 4-day adult    5 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    2 central nervous system, pupae P8    3 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    3 head, mated 1-day female    7 head, mated 4-day female    5 head, mated 20-day female    2 head, mated 1-day male    10 head, mated 4-day male    5 head, mated 20-day male    5 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    3 carcass, larvae L3 wandering    5 carcass, 1-day adult    5 carcass, 4-day adult    5 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    2 central nervous system, pupae P8    3 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    3 head, mated 1-day female    7 head, mated 4-day female    5 head, mated 20-day female    2 head, mated 1-day male    10 head, mated 4-day male    5 head, mated 20-day male    5 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    3 carcass, larvae L3 wandering    5 carcass, 1-day adult    5 carcass, 4-day adult    5 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed within 12-18 embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    2 embryo 08-10hr    3 embryo 10-12hr    11 embryo 12-14hr    13 embryo 14-16hr    22 embryo 16-18hr    17 embryo 18-20hr    13 embryo 20-22hr    3 embryo 22-24hr    3 larva L1    4 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    2 white prepupae new    1 white prepupae 12hr    2 white prepupae 24hr    6 pupae 2d postWPP    5 pupae 3d postWPP    6 pupae 4d postWPP    3 adult male 01day    3 adult male 05day    2 adult male 30day    3 adult female 01day    2 adult female 05day    0 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    2 embryo 08-10hr    3 embryo 10-12hr    11 embryo 12-14hr    13 embryo 14-16hr    22 embryo 16-18hr    17 embryo 18-20hr    13 embryo 20-22hr    3 embryo 22-24hr    3 larva L1    4 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    2 white prepupae new    1 white prepupae 12hr    2 white prepupae 24hr    6 pupae 2d postWPP    5 pupae 3d postWPP    6 pupae 4d postWPP    3 adult male 01day    3 adult male 05day    2 adult male 30day    3 adult female 01day    2 adult female 05day    0 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    2 embryo 08-10hr    3 embryo 10-12hr    11 embryo 12-14hr    13 embryo 14-16hr    22 embryo 16-18hr    17 embryo 18-20hr    13 embryo 20-22hr    3 embryo 22-24hr    3 larva L1    4 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    2 white prepupae new    1 white prepupae 12hr    2 white prepupae 24hr    6 pupae 2d postWPP    5 pupae 3d postWPP    6 pupae 4d postWPP    3 adult male 01day    3 adult male 05day    2 adult male 30day    3 adult female 01day    2 adult female 05day    0 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    2 embryo 08-10hr    3 embryo 10-12hr    11 embryo 12-14hr    13 embryo 14-16hr    22 embryo 16-18hr    17 embryo 18-20hr    13 embryo 20-22hr    3 embryo 22-24hr    3 larva L1    4 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    2 white prepupae new    1 white prepupae 12hr    2 white prepupae 24hr    6 pupae 2d postWPP    5 pupae 3d postWPP    6 pupae 4d postWPP    3 adult male 01day    3 adult male 05day    2 adult male 30day    3 adult female 01day    2 adult female 05day    0 adult female 30day    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    2 embryo 08-10hr    3 embryo 10-12hr    11 embryo 12-14hr    13 embryo 14-16hr    22 embryo 16-18hr    17 embryo 18-20hr    13 embryo 20-22hr    3 embryo 22-24hr    3 larva L1    4 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    2 white prepupae new    1 white prepupae 12hr    2 white prepupae 24hr    6 pupae 2d postWPP    5 pupae 3d postWPP    6 pupae 4d postWPP    3 adult male 01day    3 adult male 05day    2 adult male 30day    3 adult female 01day    2 adult female 05day    0 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    2 embryo 08-10hr    3 embryo 10-12hr    11 embryo 12-14hr    13 embryo 14-16hr    22 embryo 16-18hr    17 embryo 18-20hr    13 embryo 20-22hr    3 embryo 22-24hr    3 larva L1    4 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    2 white prepupae new    1 white prepupae 12hr    2 white prepupae 24hr    6 pupae 2d postWPP    5 pupae 3d postWPP    6 pupae 4d postWPP    3 adult male 01day    3 adult male 05day    2 adult male 30day    3 adult female 01day    2 adult female 05day    0 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    2 embryo 08-10hr    3 embryo 10-12hr    11 embryo 12-14hr    13 embryo 14-16hr    22 embryo 16-18hr    17 embryo 18-20hr    13 embryo 20-22hr    3 embryo 22-24hr    3 larva L1    4 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    2 white prepupae new    1 white prepupae 12hr    2 white prepupae 24hr    6 pupae 2d postWPP    5 pupae 3d postWPP    6 pupae 4d postWPP    3 adult male 01day    3 adult male 05day    2 adult male 30day    3 adult female 01day    2 adult female 05day    0 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    2 embryo 08-10hr    3 embryo 10-12hr    11 embryo 12-14hr    13 embryo 14-16hr    22 embryo 16-18hr    17 embryo 18-20hr    13 embryo 20-22hr    3 embryo 22-24hr    3 larva L1    4 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    2 white prepupae new    1 white prepupae 12hr    2 white prepupae 24hr    6 pupae 2d postWPP    5 pupae 3d postWPP    6 pupae 4d postWPP    3 adult male 01day    3 adult male 05day    2 adult male 30day    3 adult female 01day    2 adult female 05day    0 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    6 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    6 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    6 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    6 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    6 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    6 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    6 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    6 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_29
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003499 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7847-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal sr6 sr61j sr155 sr254 sr402 sr408 sr410 sr461 srR947 srT1-90E lethal | embryonic stage | recessive srG11 lethal | recessive sr3.2 sr4.2 sr61j sr100.23 sr100.312 sr03999 srG11 srVJ54 partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 srGD1540 viable sr1 srB14.0 Other Phenotypes Allele cell shape defective | embryonic stage, with Scer\GAL469B srA.Scer\UAS eye color defective srT1-90E flightless | recessive sr1 visible, with Scer\GAL4pnr-MD237 srGD1540 visible, with Scer\GAL4sca-C253 srb.Scer\UAS visible, with Scer\GAL4sr-md710 srb.Scer\UAS visible | recessive srB14.0 srVJ54rv1 Phenotype manifest in Allele abdominal 5 lateral transverse muscle | embryonic stage, with Scer\GAL4h.6 srb.Scer\UAS abdominal 5 ventral longitudinal muscle | embryonic stage, with Scer\GAL4h.6 srb.Scer\UAS abdominal 6 lateral transverse muscle | embryonic stage, with Scer\GAL4h.6 srb.Scer\UAS abdominal 6 ventral longitudinal muscle | embryonic stage, with Scer\GAL4h.6 srb.Scer\UAS abdominal 7 lateral transverse muscle | embryonic stage, with Scer\GAL4h.6 srb.Scer\UAS abdominal 7 ventral longitudinal muscle | embryonic stage, with Scer\GAL4h.6 srb.Scer\UAS adult muscle system srB14.0 adult thorax srVJ54rv1 dorsal medial muscle sr1 srB14.0 srP148 srP160 srP48 srP54 srP70 ectoderm, with Scer\GAL469B srA.Scer\UAS embryonic/larval dorsal branch srG11 embryonic/larval dorsal branch (with Df(3R)DG4) sr155 embryonic/larval dorsal branch | supernumerary, with Scer\GAL469B srScer\UAS.cBa embryonic/larval dorsal branch | supernumerary, with Scer\GAL4btl.PS srScer\UAS.cBa embryonic/larval dorsal trunk srG11 embryonic/larval dorsal trunk (with Df(3R)DG4) sr155 embryonic/larval ganglionic branch srG11 embryonic/larval ganglionic branch (with Df(3R)DG4) sr155 embryonic/larval muscle system (with Df(3R)DG4) sr155 embryonic/larval somatic muscle sr155 embryonic/larval somatic muscle, with Scer\GAL4en-e16E srScer\UAS.cBa srb.Scer\UAS embryonic/larval somatic muscle, with Scer\GAL4hs.2sev srb.Scer\UAS embryonic/larval somatic muscle, with Scer\GAL4ptc-559.1 srScer\UAS.cBa srb.Scer\UAS embryonic/larval somatic muscle | ventral, with Scer\GAL4sim.PS srb.Scer\UAS embryonic/larval visceral branch (with Df(3R)DG4) sr155 embryonic somatic muscle, with Scer\GAL469B srA.Scer\UAS srB.Scer\UAS embryonic somatic muscle | lateral, with Df(3R)DG4, Scer\GAL4sim.PS srScer\UAS.cBa germ band, with Scer\GAL469B srA.Scer\UAS lateral transverse muscle | embryonic stage, with Scer\GAL4en-e16E srScer\UAS.cBa srb.Scer\UAS lateral transverse muscle | embryonic stage, with Scer\GAL4ptc-559.1 srScer\UAS.cBa lch5 cap attachment cell (with Df(3R)DG4) sr155 lch5 ligament attachment cell (with Df(3R)DG4) sr155 macrochaeta srB14.0 mesothoracic tergum, with Scer\GAL4pnr-MD237 srGD1540 mesothoracic tergum & chaeta, with Scer\GAL4sca-C253 srb.Scer\UAS mesothoracic tergum & microchaeta, with Scer\GAL4sr-md710 srb.Scer\UAS muscle attachment site sr155 muscle fiber sr155 skeletal muscle of abdomen srVJ54 somatic mesoderm srP1 somatic muscle | embryonic stage, with Df(3R)DG4, Scer\GAL4ptc-559.1 srScer\UAS.cBa thorax srVJ54
Classical Alleles ( 53 )
For All Classical Alleles Show
Allele of sr Class Mutagen Stocks Known lesion sr1 spontaneous 197 -- sr03999 P-element activity 1 Yes sr155 loss of function allele 1 Yes sr461 1 -- sr5-SZ-3026 1 -- sr5-SZ-3943 1 -- sr61j X ray 1 -- srd02319 P-element activity 1 -- srd02401 P-element activity 1 -- srf02528 piggyBac transposase 1 -- srf06007 piggyBac transposase 1 -- srf06021 piggyBac transposase 1 -- srMB04757 1 -- srmd710 P-element activity 1 Yes srUM-8233-3 1 -- srVJ54 amorphic allele - genetic evidence P-element activity 0 -- sr06915b P-element activity 0 -- sr06948b P-element activity 0 -- sr100.23 X ray 0 -- sr100.312 X ray 0 -- sr16 0 -- sr254 0 -- sr3.2 X ray 0 -- sr300.240 X ray 0 -- sr4.2 X ray 0 -- sr402 0 -- sr408 0 -- sr410 0 -- sr56k spontaneous 0 -- sr5 0 -- sr6 0 -- srB14.0 hypomorphic allele - genetic evidence P-element activity 0 -- srbsc 0 -- srd01833 P-element activity 0 -- srd02861 P-element activity 0 -- srd04466 0 -- srd06094 P-element activity 0 -- srd08041 P-element activity 0 -- srd08453 P-element activity 0 -- srd09155 P-element activity 0 -- srG11 Delta2-3 0 Yes srP148 P-element activity 0 -- srP160 P-element activity 0 -- srP1 PM hybrid dysgenesis 0 Yes srP48 P-element activity 0 -- srP54 P-element activity 0 -- srP70 P-element activity 0 -- srR947 0 -- srT1-90E P-element activity 0 Yes srunspecified 0 -- srVJ54rv1 hypomorphic allele - genetic evidence P-element activity 0 -- srΔ30 Delta2-3 0 Yes srΔ51 Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Allele of sr Class Mutagen Stocks Known lesion srb.Scer\UAS in vitro construct - regulatory fusion 2 Yes srGD1540 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes srJF02781 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes srKK107677 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes srA.Scer\UAS in vitro construct - regulatory fusion 0 Yes srB-3'UTR.Scer\UAS in vitro construct - regulatory fusion 0 Yes srB.Scer\UAS in vitro construct - regulatory fusion 0 Yes srint1.Scer\UAS in vitro construct - regulatory fusion 0 Yes srNIG.7847R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes srScer\UAS.cBa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Duplicated in	Dp(3;1)O5 (Oliver, 1937) Dp(3;3)DG (Gailey and Hall, 1989)
Disrupted in	Df(3R)BSC510 (Christensen et al., 2008.4.15) Df(3R)BSC566 (Cook et al., 2008.7.11) Df(3R)BX6 (Gailey and Hall, 1989, Bellen et al., 1992) Df(3R)DG1 (Gailey and Hall, 1989) Df(3R)DG2 (Gailey and Hall, 1989) Df(3R)DG3 (Gailey and Hall, 1989) Df(3R)DG4 (Gailey and Hall, 1989, Bellen et al., 1992, Frommer et al., 1996) Df(3R)Exel6287 (Ryder, 2004.4.26) Df(3R)gl-BX10 (Gailey and Hall, 1989, Bellen et al., 1992) Df(3R)P14 (Spradling et al., 1999, Gailey and Hall, 1989, Bellen et al., 1992, BDGP Project Members, 1994-1999) Df(3R)p712 (BDGP Project Members, 1994-1999) Df(3R)sr16 (Bellen et al., 1992, Goubeaud et al., 1996, Beiman et al., 1996) Df(3R)sr100.394 (Ward and Alexander, 1957) Df(3R)sr300.24 (Ward and Alexander, 1957) Df(3R)sr300.101 (Ward and Alexander, 1957) Df(3R)sr1461 (Bellen et al., 1992) Df(3R)Δ30 (Beiman et al., 1996) Df(3R)Δ51 (Beiman et al., 1996) In(3R)iab9Tab (Lee et al., 1995, Fernandes et al., 1996) T(2;3)sr100.312 (Ward and Alexander, 1957) T(Y;3)sr100.23 (Ward and Alexander, 1957) Tp(3;3)sr300.240 (Ward and Alexander, 1957)
Not disrupted in	Df(3R)BX5 (Gailey and Hall, 1989) Df(3R)Cha1a (Gailey and Hall, 1989) Df(3R)Cha5 (Gailey and Hall, 1989) Df(3R)Cha7 (Gailey and Hall, 1989) Df(3R)ChaM5 (Gailey and Hall, 1989) Df(3R)DG5 (Gailey and Hall, 1989) Df(3R)gl-BX1 (Gailey and Hall, 1989, Bellen et al., 1992)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1540} NA P{KK107677} NA P{NIG.7847R} NA P{TRiP.JF02781} NA P{UAS-sr.B-3'UTR} NA P{UAS-sr.b.V} NA P{UAS-sr.B} NA P{UAS-sr.isoA} NA P{UAS-sr.isoB} NA reporter construct P{sr-lacZ.1.9} No P{sr-lacZ.239} No P{sr-lacZ.Δci1} No P{sr-lacZ.Δci2} No P{sr-lacZ.ΔPan} No characterization construct P{UAS-en::sr.rep} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacZ}srVJ54 No P{lwB}srB14.0 No P{lwB}srP48 No P{lwB}srP54 No P{lwB}srP70 No P{lwB}srP148 No P{lwB}srP160 No P{PZ}sr03999 No P{PZ}sr06915b No P{PZ}sr06948b No miscellaneous insertions P{}srP1 NA P{RS3}srUM-8233-3 NA P{RS5}sr5-SZ-3026 NA P{RS5}sr5-SZ-3943 NA P{T1}srT1-90E NA PBac{WH}srf02528 NA PBac{WH}srf06007 NA PBac{WH}srf06021 NA insertion of mobile activating element P{XP}srd01833 NA P{XP}srd02319 NA P{XP}srd02401 NA P{XP}srd02861 NA P{XP}srd04466 NA P{XP}srd06094 NA P{XP}srd08041 NA P{XP}srd08453 NA P{XP}srd09155 NA insertion of enhancer trap binary system Mi{ET1}srMB04757 No P{GawB}srmd710 No
Gene Ontology: Function, Process & Cellular Component ( 13 unique terms )
Terms Based on Experimental Evidence ( 7 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
central nervous system development inferred from mutant phenotype (de la Pompa et al., 1989) ectoderm development inferred from mutant phenotype (Volohonsky et al., 2007) epithelial cell migration, open tracheal system inferred from genetic interaction with bnl AND inferred from mutant phenotype (Dorfman et al., 2002) germ-band shortening inferred from mutant phenotype (Volohonsky et al., 2007) muscle organ development inferred from mutant phenotype (de la Pompa et al., 1989) phagocytosis, engulfment inferred from mutant phenotype (Stroschein-Stevenson et al., 2006) somatic muscle development inferred from mutant phenotype (Volohonsky et al., 2007)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
nucleic acid binding inferred from electronic annotation with InterPro:IPR013087 (FlyBase Curators et al., 2004-) zinc ion binding inferred from electronic annotation with InterPro:IPR007087, InterPro:IPR015880 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
determination of muscle attachment site traceable author statement (Bate et al., 1999, Sanson, 2001) pigment metabolic process traceable author statement (Calleja et al., 2002) regulation of transcription, DNA-dependent inferred from sequence or structural similarity (Lee et al., 1995)
Cellular Component
CV term Evidence References
nucleus inferred from sequence or structural similarity (Lee et al., 1995)
Sequence Ontology: Class of Gene
	gene_with_stop_codon_read_through (Jungreis et al., 2011) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions sr allele Gene References sr1 ac (Usui et al., 2004) sr03999 ap (Ghazi et al., 2000) sr06948b sev (Maixner et al., 1998) srb.Scer\UAS sc (Usui et al., 2004) srG11 ap (Ghazi et al., 2000) srScer\UAS.cBa bnl (Dorfman et al., 2002)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 67186 DroID - A comprehensive database of gene and protein interactions. • FBgn0003499 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42162
Orthologs
OrthoDB Orthologs (22) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6TTH4H Dipteran inclusive ortholog search EOG6BG958 Insect inclusive ortholog search EOG6FTTVJ, EOG6Q57KT Arthropod inclusive ortholog search EOG6B2RC4 Metazoa inclusive ortholog search EOG65XMQX
Orthologs in Drosophila Species (EOG6TTH4H)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG8086     Drosophila melanogaster fruit fly  Dmel\sr     Drosophila persimilis   Dper\GL19387   Y Drosophila virilis   Dvir\GJ20592   Y
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (EOG6FTTVJ, EOG6Q57KT)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB46013 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG012516 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH14696 Y Atta cephalotes Leafcutter ant  Acep\ACEP24112 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO13956 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL18830 Y Linepithema humile Argentine ant  Lhum\LH18833 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB22356 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB22357 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB26978 Y Solenopsis invicta Red fire ant  Sinv\SINV11221 Y Solenopsis invicta Red fire ant  Sinv\SINV11223 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI009245 Y Bombyx mori Silkmoth  Bmor\BGIBMGA001178 Y Pediculus humanus Human body louse  Phum\PHUM060380 Y Tribolium castaneum Red flour beetle  Tcas\GLEAN_08298 Y
Orthologs in non-Insect Arthropods (EOG6B2RC4)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_309816 Y Ixodes scapularis Deer tick  Isca\ISCW000405 Y
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD19200 Drosophila sechellia Dsec\GM15276 Drosophila erecta Dere\GG22637 Drosophila yakuba Dyak\GE25511 Drosophila ananassae Dana\GF16755 Drosophila pseudoobscura pseudoobscura Dpse\GA27565 Drosophila persimilis Dper\GL12588 Drosophila willistoni Dwil\GK11242 Drosophila virilis Dvir\GJ23272 Drosophila mojavensis Dmoj\GI23713 Drosophila grimshawi Dgri\GH15079
Stocks & Reagents
Stocks Listed in FlyBase ( 216 )
Bloomington	598 sr1 519 Hnr3 sr1 36533 w*; P{UAS-sr.b.V}59 36534 w*; P{UAS-sr.b.V}20.1
Harvard	- P{XP}srd02319 - P{XP}srd02401 - PBac{WH}srf02528 - PBac{WH}srf06007 - PBac{WH}srf06021
Kyoto	106000 sr1 105959 Hnr3 sr1
VDRC	v105282 P{KK107677}VIE-260B
	More stocks available...
Genomic Clones ( 3 )
	BACR01C15 BACR27G04 BACR35E22 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 7 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE58041
Other clones	FI18283
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RH53135
Other clones	214439.70 EP09829 RP003079691 RP003133815
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0003499 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42162
Antibody Information
	polyclonal (Frommer et al., 1996, Frommer et al., 1996)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: sr CG7847 (Gong, 1999.11)
Source for database merge of	Source for merge of: sr l(3)06948b (Beaton, 1999.12.12)
Additional comments
Other Comments
	S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells. (Stroschein-Stevenson et al., 2006) sr acts co-operatively with bnl to facilitate extension of tracheal branches. (Dorfman et al., 2002) sr is necessary and sufficient to initiate the developmental program of epidermal muscle attachment cells. (Becker et al., 1997) sr activity controls the expression of epidermal muscle attachment site-specific target genes in cells of ectodermal but not mesodermal origin. sr-expressing ectodermal cells generate long-range signals that interfere with the spatial orientation of elongating myotubes. (Vorbruggen and Jackle, 1997) Cloning and molecular characterisation of sr reveals that sr activity induces a subset of ectodermal cells to develop into muscle attachment sites and to provide spatial cues necessary to orient myotubes along the basal surface of the epidermis to their targeted attachment cells. (Frommer et al., 1996) sr gene product is required for apodeme development or muscle/apodeme attachment. (Frommer et al., 1995) sr plays a role in intercellular communication required for normal muscle development. sr mediates muscle development through its expression in cells that interact with developing muscle. (Lee et al., 1995) sr is expressed in the ectoderm at the future muscle attachment sites and may be required for apodeme differentiation to enable the correct targeting by the approaching myotubule. (Volk et al., 1995) The sr gene is expressed at the segment border of the embryo and mutants at the sr locus affect muscle patterning. (Volk and Vijay Raghavan, 1994) Mutants in sr specifically affect the dorsolateral muscles. (de la Pompa et al., 1989) Mutant individuals display a dark median stripe on the thorax. (Duncan and Kaufman, 1975)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079671 NM_169786 NM_001170172 NM_001275764 RefSeq (Proteins) • NP_524395 NP_732289 NP_001163643 NP_001262693 DDBJ / EMBL / GenBank • AAB02354 AAB02355 AAB35453 AAF55492 AAN13756 ACZ94939 AGB96073 BI371195 CZ472469 CZ472747 CZ472788 CZ473037 CZ474916 CZ474917 CZ476049 CZ476239 CZ476588 CZ476589 CZ485053 CZ488640 CZ488641 CZ488662 G00573 S79891 U42402 U42403 Entrez Gene - A searchable database of RefSeq genes. • 42162 UniProtKB/TrEMBL • E1JIP0 Q7JP26 Q8IN91 Q9VED3 Q24163 Q26452
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger C2H2-type/integrase DNA-binding domain (IPR013087) Zinc finger, C2H2-like (IPR015880) Zinc finger, C2H2 (IPR007087)
Linkouts
	BioGRID - A database of protein and genetic interactions • 67186 DroID - A comprehensive database of gene and protein interactions. • FBgn0003499 DRSC - Results from RNAi screens. • FBgn0003499 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003499 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7847-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0003499 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42162 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /gene/stripe.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42162 modMine - Data generated by the modENCODE project. • FBgn0003499
Synonyms & Secondary IDs ( 12 )
Reported As
Symbol Synonym	CG7847 (Keleman et al., 2009.8.5, Perkins et al., 2009) l(3)03999   l(3)06948 (Maixner et al., 1998) l(3)06948b   Sr (Jones, 2001, Olguín et al., 2011, Enriquez et al., 2012, Egoz-Matia et al., 2011) sr (Simpson, 2006, Stroschein-Stevenson et al., 2006, Cook et al., 2008.7.11, Chanana et al., 2007, Dilks and DiNardo, 2008, Christensen et al., 2008.4.15, Whitlock and Bourguet, 2000, Liu and Geisbrecht, 2011, Guerin and Kramer, 2009, Jungreis et al., 2011, Nabel-Rosen et al., 2002, Sandmann et al., 2006, Marcellini and Simpson, 2006, Wang et al., 2008, Takahashi and Ting, 2004, Staudt et al., 2005, Usui et al., 2008, Zeitlinger et al., 2007, Wayburn and Volk, 2009, Meyer et al., 2008, Klein et al., 2010, Dilks and DiNardo, 2010, Krzemien et al., 2012, Lahaye et al., 2012, Abruzzi et al., 2011, Japanese National Institute of Genetics, 2012.5.21) SrB (Enriquez et al., 2012) stripe (Staudt et al., 2005)
Name Synonym	Stripe (Bassett et al., 1997, Boukhatmi et al., 2012, Volohonsky et al., 2007, Subramanian et al., 2007, Dilks and DiNardo, 2008, Bahri et al., 2009, O'Farrell and Kylsten, 2008, Klein et al., 2010) stripe (Frommer, 1995.12.6, Frommer, 1995.12.6, Volk et al., 1997, IKMI and COEN, 2007, Barmina et al., 2005, Simpson, 2006, Chanana et al., 2007, Haynes et al., 2006, Israeli et al., 2007, Staudt et al., 2005, Whitlock and Bourguet, 2000, Liu and Geisbrecht, 2011, Nabel-Rosen et al., 2002, Marcellini and Simpson, 2006, Takahashi and Ting, 2004, Usui et al., 2008, Wayburn and Volk, 2009, Gilsohn and Volk, 2010, Dilks and DiNardo, 2010, Cirelli et al., 2005, Krzemien et al., 2012) STRIPE (Lahaye et al., 2012) StripeB (Enriquez et al., 2012) Striped (Jones, 2001)
Secondary FlyBase IDs
	FBgn0010828 FBgn0026215
References ( 197 )
Generate a list of	All references relating to this gene ( 197 )
List References by type	Research paper  ( 116 ) Supplementary material  ( 8 ) Review  ( 18 ) Personal communication to FlyBase  ( 19 ) Abstract  ( 26 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 2 ) Stock list  ( 1 ) Curated genome annotation  ( 3 ) Book  ( 1 )
Recent research papers ( 9 )
	Boukhatmi et al., 2012, Development 139(19): 3572--3582 Tup/Islet1 integrates time and position to specify muscle identity in Drosophila. [FBrf0219376] Enriquez et al., 2012, Dev. Biol. 363(1): 27--39 Combinatorial coding of Drosophila muscle shape by Collier and Nautilus. [FBrf0217465] Krzemien et al., 2012, Development 139(1): 75--83 The muscle pattern of the Drosophila abdomen depends on a subdivision of the anterior compartment of each segment. [FBrf0216853] Lahaye et al., 2012, PLoS ONE 7(3): e32297 WNT5 Interacts with the Ryk Receptors Doughnut and Derailed to Mediate Muscle Attachment Site Selection in Drosophila melanogaster. [FBrf0217725] Weber et al., 2012, PLoS ONE 7(4): e34745 Genome-Wide Association Analysis of Oxidative Stress Resistance in Drosophila melanogaster. [FBrf0218073] Abruzzi et al., 2011, Genes Dev. 25(22): 2374--2386 Drosophila CLOCK target gene characterization: implications for circadian tissue-specific gene expression. [FBrf0216798] Egoz-Matia et al., 2011, Dev. Biol. 351(1): 99--109 Spatial regulation of cell adhesion in the Drosophila wing is mediated by Delilah, a potent activator of βPS integrin expression. [FBrf0213026] Ghabrial et al., 2011, PLoS Genet. 7(7): e1002087 A systematic screen for tube morphogenesis and branching genes in the Drosophila tracheal system. [FBrf0214368] Liu and Geisbrecht, 2011, Dev. Biol. 359(2): 176--189 Moleskin is essential for the formation of the myotendinous junction in Drosophila. [FBrf0216515] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...