FlyBase Gene Report: Dmel\Btk29A

General Information

Symbol

Dmel\Btk29A

Species

D. melanogaster

Name

Btk family kinase at 29A

Annotation Symbol

CG8049

Feature Type

protein_coding_gene

FlyBase ID

FBgn0003502

Gene Model Status

Current

Stock Availability

26 publicly available

Enzyme Name (EC)

Non-specific protein-tyrosine kinase (2.7.10.2)

Gene Summary

Btk family kinase at 29A (Btk29A) encodes a non-receptor tyrosine kinase with diverse roles including cellularization, morphogenesis, patterning and germ cell proliferation. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Red Book
Interactive Fly

Also Known As

Tec29, Dsrc28C, Tec29A, fic, dsrc29A

Key Links

Genomic Location

Cytogenetic map

29A1-29A3

Sequence location

2L:8,258,373..8,301,079 [-]

Recombination map

2-31

RefSeq locus

NT_033779 REGION:8258373..8301079

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (30 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables protein tyrosine kinase activity

inferred from direct assay

(Theroux and Wadsworth, 1992)

inferred from mutant phenotype

(Hamada-Kawaguchi et al., 2014)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables ATP binding

inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR017441

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

enables non-membrane spanning protein tyrosine kinase activity

inferred from biological aspect of ancestor with PANTHER:PTN001231474

(assigned by GO_Central )

(Gaudet et al., 2011)

enables protein tyrosine kinase activity

inferred from biological aspect of ancestor with PANTHER:PTN002521457

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (22 terms)

Terms Based on Experimental Evidence (17 terms)

CV Term

Evidence

References

involved_in actin cytoskeleton organization

inferred from mutant phenotype

(Djagaeva et al., 2005)

involved_in cellularization

inferred from mutant phenotype

(Thomas and Wieschaus, 2004)

involved_in determination of adult lifespan

inferred from mutant phenotype

(assigned by UniProt )

(Baba et al., 1999)

involved_in DNA endoreduplication

inferred from mutant phenotype

(Chandrasekaran and Beckendorf, 2005)

involved_in female germline ring canal formation

inferred from mutant phenotype

(Hamada-Kawaguchi et al., 2015, Roulier et al., 1998)

inferred from direct assay

(assigned by UniProt )

(Dodson et al., 1998, Guarnieri et al., 1998)

involved_in head involution

inferred from mutant phenotype

(Roulier et al., 1998)

involved_in imaginal disc-derived male genitalia development

inferred from mutant phenotype

(Hamada et al., 2005)

inferred from mutant phenotype

(assigned by UniProt )

(Baba et al., 1999)

involved_in oocyte karyosome formation

inferred from mutant phenotype

(Djagaeva et al., 2005)

involved_in oogenesis

inferred from mutant phenotype

(Djagaeva et al., 2005)

involved_in open tracheal system development

inferred from mutant phenotype

(Matusek et al., 2006)

involved_in ovarian fusome organization

inferred from mutant phenotype

(Djagaeva et al., 2005)

involved_in ovarian nurse cell to oocyte transport

inferred from mutant phenotype

(Djagaeva et al., 2005)

involved_in peptidyl-tyrosine phosphorylation

inferred from direct assay

(Theroux and Wadsworth, 1992)

inferred from mutant phenotype

(Hamada-Kawaguchi et al., 2015)

involved_in regulation of actin filament polymerization

inferred from mutant phenotype

(Chandrasekaran and Beckendorf, 2005)

involved_in salivary gland morphogenesis

inferred from mutant phenotype

(Chandrasekaran and Beckendorf, 2005)

involved_in sensitization

inferred from mutant phenotype

(Asztalos et al., 2007)

involved_in spiracle morphogenesis, open tracheal system

inferred from mutant phenotype

(Tsikala et al., 2014)

Terms Based on Predictions or Assertions (5 terms)

CV Term

Evidence

References

involved_in courtship behavior

non-traceable author statement

(Sokolowski, 2001)

involved_in dorsal closure

traceable author statement

(Harden, 2002)

involved_in intracellular signal transduction

inferred from electronic annotation with InterPro:IPR001562

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

involved_in JNK cascade

traceable author statement

(Harden, 2002)

involved_in peptidyl-tyrosine autophosphorylation

inferred from biological aspect of ancestor with PANTHER:PTN001231474

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (5 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

located_in apical part of cell

inferred from direct assay

(Tsikala et al., 2014)

located_in cell periphery

inferred from direct assay

(Tsikala et al., 2014)

located_in cytoplasm

inferred from direct assay

(Wadsworth et al., 1990)

located_in germline ring canal

inferred from direct assay

(assigned by UniProt )

(Dodson et al., 1998, Guarnieri et al., 1998)

located_in plasma membrane

inferred from direct assay

(Wadsworth et al., 1990)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

NON-RECEPTOR TYROSINE KINASES

Protein Family (UniProt)

Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily. (P08630)

Protein Signatures (InterPro)

Catalytic Activity (EC)

Experimental Evidence

Predictions / Assertions

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate (2.7.10.2)

Summaries

Gene Snapshot

Gene Group (FlyBase)

NON-RECEPTOR TYROSINE KINASES -: Non-Receptor Tyrosine kinases (nRTK) are cytoplasmic protein kinases that specifically phosphorylate tyrosine residues. nRTKs are involved in signalling cascades and possess targeting domains such as SH2 domains. (Adapted from FBrf0132098).

Protein Function (UniProtKB)

Required for proper ring canal development. Also required for the development of male genitalia and for adult survival.

(UniProt, P08630)

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

Src2

Src transcripts abundant in early embryos and in adult ovaries; also found in imaginal disks. Level declines in later embryos and is low in males and ovarectomized females. Inferred to be maternally acting gene whose product is required for early embryogenesis (Wadsworth et al.). Monoclonal antibodies detect two protein products of Src2, a doublet of 66 kd and one of 55 kd; the 55 kd polypeptide appears to initiate at the third methionine codon of the sequence; a faint 95 kd band appears to track the 66 kd band in developmental Northern blots. Monoclonal antibodies that differentiate between the two protein products show that they are differentially regulated. The 66 kd polypeptide first appears at the periphery of cells of the cellular blastoderm; this staining is transiently resolved into 13 or 14 segmental stripes plus uncharacterized staining in the head region in the fully extended germ band; no 66 kd protein detectable after 12 h of development. The 55 kd polypeptide first appears at 4-6 h and is widely distributed in the central and peripheral nervous systems. Larvae transformed with constructs that produce either the 66 or the 55 kd products under Hsp70 promoter action display cell-surface localization of the 66 kd protein and cytoplasmic localization of the 55 kd protein in third-instar salivary glands.

Summary (Interactive Fly)

protein-tyrosine kinase - necessary for maintaining the equilibrium between monomeric actin and filamentous actin during invagination of the salivary placodes - functions during oogenesis as a key downstream effector of Src64 during ring canal growth - targets β-catenin, which functions downstream of Wnt4 in escort cells to terminate Drosophila germ cell proliferation through up-regulation of expression

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Btk29A for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure New Section

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry P08630)

If you don't see the viewer to the right, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Gene model reviewed during 5.55

Gene model reviewed during 5.45

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.44

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Gene model reviewed during 5.56

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Btk29A-RA

FBtr0079618

NM_057398

4026

603

Btk29A-RB

FBtr0079616

NM_057397

3420

786

Btk29A-RC

FBtr0079615

NM_164805

3279

603

Btk29A-RD

FBtr0079617

NM_164804

3674

786

Btk29A-RE

FBtr0112836

NM_001103651

4785

786

Btk29A-RF

FBtr0112835

NM_001103650

4992

603

Btk29A-RG

FBtr0330692

NM_001273314

3302

565

Btk29A-RH

FBtr0330693

NM_001273315

3826

464

Additional Transcript Data and Comments

Reported size (kB)

4.0, 3.0 (northern blot)

(Baba et al., 1999)

3.5 (northern blot)

(Gregory et al., 1987)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Btk29A-PA

FBpp0079238

66.8

603

8.80

NP_476746

AAF52631

Btk29A-PB

FBpp0079236

87.4

786

9.39

NP_476745

AAF52632

Btk29A-PC

FBpp0079235

66.8

603

8.80

NP_723370

AAN11162

Btk29A-PD

FBpp0079237

87.4

786

9.39

NP_723369

AAN11161

Btk29A-PE

FBpp0111749

87.4

786

9.39

NP_001097121

ABV53649

Btk29A-PF

FBpp0111748

66.8

603

8.80

NP_001097120

ABV53648

Btk29A-PG

FBpp0303535

62.4

565

8.74

NP_001260243

AGB92779

Btk29A-PH

FBpp0303536

52.9

464

8.60

NP_001260244

AGB92780

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

603 aa isoforms: Btk29A-PA, Btk29A-PC, Btk29A-PF

786 aa isoforms: Btk29A-PB, Btk29A-PD, Btk29A-PE

Additional Polypeptide Data and Comments

Reported size (kDa)

786, 603 (aa)

(Baba et al., 1999)

66, 55 (kD)

(Theroux and Wadsworth, 1992)

590 (aa); 66 (kD)

(Gregory et al., 1987)

Comments

The 55kD gene product of Btk29A differs from

the 66kD product by the absence of the 125 N-terminal amino acids. When

expressed in Sf9 cells via a recombinant baculovirus system it does not

exhibit detectable protein tyrosine-kinase activity. The p55 product lacks

an N-terminal myristylation signal.

(Theroux and Wadsworth, 1992)

In addition to the 66 and 55 kD Btk29A proteins, a 95 kD protein is observed on Western blots.

(Vincent et al., 1989)

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Btk29A using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

dot blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

(Wadsworth et al., 1985)

prepupal stage -- pupal stage

(Wadsworth et al., 1985)

adult stage

(Wadsworth et al., 1985)

oogenesis & adult stage | female

ovary

(Wadsworth et al., 1985)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

epithelial cell

• cytoplasm | apical

Comment: clustered apical distribution

(Lecuyer et al., 2007)

epithelium

• cytoplasm | apical

(Lecuyer et al., 2007)

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

dorsal ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

foregut anlage in statu nascendi

(Fisher et al., 2012)

organism | gap expression pattern

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

ventral ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

embryonic stage 7 -- 8

antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

anterior endoderm anlage

(Fisher et al., 2012)

dorsal ectoderm

(Fisher et al., 2012)

foregut anlage

(Fisher et al., 2012)

hindgut anlage

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

ventral nerve cord primordium

Comment: reported as ventral nerve cord anlage

(Fisher et al., 2012)

embryonic stage 9 -- 10

antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

anterior endoderm

(Fisher et al., 2012)

dorsal ectoderm

(Fisher et al., 2012)

foregut primordium

(Fisher et al., 2012)

inclusive hindgut primordium

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 11 -- 17

posterior spiracle primordium

(Tsikala et al., 2014)

third instar larval stage

embryonic/larval garland cell

(Tutor et al., 2014)

wandering third instar larval stage

wing pouch | restricted

(Molnar et al., 2012)

wing hinge primordium | restricted

(Molnar et al., 2012)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

(Gregory et al., 1987)

larval stage -- pupal stage

midline glial cell

(Baba et al., 1999)

neuron | subset

(Baba et al., 1999)

mushroom body

(Baba et al., 1999)

antennal lobe

(Baba et al., 1999)

third instar larval stage

imaginal disc

(Gregory et al., 1987)

pupal stage

male genital disc | restricted

(Baba et al., 1999)

adult stage

adult head

(Baba et al., 1999)

adult stage | female

(Gregory et al., 1987)

adult stage & oogenesis

oocyte

(Gregory et al., 1987)

nurse cell

(Gregory et al., 1987)

radioisotope in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 4

organism | ubiquitous

(Katzen et al., 1990)

embryonic stage 5

amnioserosa anlage in statu nascendi

(Katzen et al., 1990)

hindgut anlage | restricted

Comment: proctodeum anlage

(Katzen et al., 1990)

embryonic stage 5 -- 6

(Katzen et al., 1990)

embryonic stage 8 -- 11

procephalic segment

(Katzen et al., 1990)

ectoderm | segmentally repeated

(Katzen et al., 1990)

amnioserosa

(Katzen et al., 1990)

embryonic stage 9 -- 12

anterior midgut primordium

(Katzen et al., 1990)

proctodeum

(Katzen et al., 1990)

posterior midgut primordium

(Katzen et al., 1990)

embryonic stage 12

gnathal segment

(Katzen et al., 1990)

stomodeal invagination | anterior

(Katzen et al., 1990)

labral segment

(Katzen et al., 1990)

embryonic stage 12 -- 14

embryonic/larval salivary gland

(Katzen et al., 1990)

embryonic stage 12 -- 17

presumptive embryonic/larval central nervous system | presumptive

(Katzen et al., 1990)

embryonic stage 15

tracheal section | restricted

(Katzen et al., 1990)

embryonic/larval posterior spiracle

(Katzen et al., 1990)

embryonic stage 16 -- 17

epidermis

(Katzen et al., 1990)

larval stage -- adult stage

central nervous system

(Katzen et al., 1990)

third instar larval stage

embryonic/larval lymph gland

(Katzen et al., 1990)

imaginal disc

(Katzen et al., 1990)

gonad

(Katzen et al., 1990)

prepupal stage

histoblast

(Katzen et al., 1990)

lamellocyte

(Katzen et al., 1990)

prepupal stage -- pupal stage

pupal/adult digestive system | restricted

(Katzen et al., 1990)

pupal stage

imaginal disc | restricted

(Katzen et al., 1990)

genital disc | restricted

(Katzen et al., 1990)

adult stage

adult proventriculus

(Katzen et al., 1990)

adult dorsal vessel

(Katzen et al., 1990)

ejaculatory bulb | restricted

(Katzen et al., 1990)

adult stage & oogenesis

nurse cell

(Katzen et al., 1990)

ovary

(Katzen et al., 1990)

Additional Descriptive Data

Btk29A transcript is expressed in posterior spiracle cells, and their precursors, from embryonic stage 11 through the end of embryogenesis.

(Tsikala et al., 2014)

Type 1 and type 2 Btk29A transcripts are expressed in mutually exclusive patterns in the pupal and larval genital and nervous systems. Type 2 transcript is expressed in the male pupal genital disc along the edge of the male genital primordium facing the lumen, which is thought to give rise to main body of the male genitalia. In the larval and pupal CNS, type 2 transcript is detected in the mushroom body and antennal lobe, while type 1 transcript is detected in dispersed neurons and midline glial cells.

(Baba et al., 1999)

Type 1 and type 2 Btk29A transcripts are expressed in mutually exclusive patterns in the pupal and larval genital and nervous systems. Type 1 transcript expression in the male pupal genital disc is restricted to the anterior bulbus, which will give rise to the internal genitalia.In the larval and pupal CNS, type 2 transcript is detected in the mushroom body and antennal lobe, while type 1 transcript is detected in dispersed neurons and midline glial cells.

(Baba et al., 1999)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

epitope tag

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | female

ring canal

(Lu et al., 2004)

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 5

furrow canal | restricted

(Thomas and Wieschaus, 2004)

embryonic stage 5 -- 17

organism

(Vincent et al., 1989)

extended germ band stage

organism | striped

(Vincent et al., 1989)

embryonic stage 11 -- 17

posterior spiracle primordium

(Tsikala et al., 2014)

embryonic stage 13 -- 17

peripheral nervous system

(Vincent et al., 1989)

presumptive embryonic/larval central nervous system

(Vincent et al., 1989)

first instar larval stage

embryonic/larval central nervous system

(Vincent et al., 1989)

adult stage & oogenesis

ring canal

(Roulier et al., 1998)

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 9 -- 16

Comment: reference states 4-14 hr AEL

(Vincent et al., 1989)

embryonic stage 9 -- 17

Comment: reference states >=4 hr AEL

(Vincent et al., 1989)

adult stage | female

ovary

(Lu et al., 2004)

Additional Descriptive Data

Btk29A protein is expressed in posterior spiracle cells, and their precursors, from embryonic stage 11 through the end of embryogenesis.

(Tsikala et al., 2014)

Type 2 protein is the predominant form in the female germline.

(Lu et al., 2004)

Btk29A protein is localized strongly to the cellularization front, and less strongly to the apico-lateral membrane, during cellularization of the embryo.

(Thomas and Wieschaus, 2004)

Btk29A protein is detected in egg chambers. It is detected in ring canals starting at region 2b of the germarium through the remainder of oogenesis.

(Roulier et al., 1998)

The 55 kD Btk29A protein is first detected at 4-6 hr of embryogenesis, and persists through the rest of embryogenesis. It is likely that the 55 kD protein is the nervous-system-specific cytoplasmic form.

(Vincent et al., 1989)

A reticular pattern of staining around the periphery of ectodermal cells is observed in cellular blastoderm embryos, and persists through early germ band extension. A transient (1 hr) 13-14 striped pattern of expression is observed at full germ band extension. After the striped pattern fades, Btk29A protein is observed in the central and peripheral nervous systems, and is no longer peripheral, but cytoplasmic.

(Vincent et al., 1989)

Marker for

ring canal

(Lu et al., 2004)

Subcellular Localization

CV Term

Evidence

References

located_in apical part of cell

inferred from direct assay

(Tsikala et al., 2014)

located_in cell periphery

inferred from direct assay

(Tsikala et al., 2014)

located_in cytoplasm

inferred from direct assay

(Wadsworth et al., 1990)

located_in germline ring canal

inferred from direct assay

(assigned by UniProt )

(Dodson et al., 1998, Guarnieri et al., 1998)

located_in plasma membrane

inferred from direct assay

(Wadsworth et al., 1990)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Btk29A in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Btk29A

View exonic expression by tissue for Dmel\Btk29A

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0003502

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34132/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0003502

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0003502

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0003502

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG8049

Flygut - An atlas of the Drosophila adult midgut

FBgn0003502

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Btk29A

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 39 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 35 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Btk29A

Transgenic constructs containing regulatory region of Btk29A

Aberrations (Deficiencies and Duplications) ( 7 )

Inferred from experimentation ( 7 )

Gene disrupted in

Df(2L)BSC111

(Deal and Cook, 2005.6.1)

Df(2L)BSC200

(Christensen and Cook, 2006.8.30)

Df(2L)BSC227

(Christensen and Cook, 2006.12.5)

Df(2L)BSC229

(Christensen and Cook, 2006.12.5)

Df(2L)BSC235

(Christensen and Cook, 2006.12.5)

Df(2L)TE29Aa-11

(Baba et al., 1999, Spradling et al., 1999, BDGP Project Members, 1994-1999)

Df(2L)TE29Aa-14

(Roulier et al., 1998)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal (with Df(2L)BSC200)

Btk29A^{MI02986-TG4.1}

lethal | recessive

lethal - all die before end of first instar larval stage

Btk29A^k05610

lethal - all die during embryonic stage | partially (with Btk29A^k00206)

Btk29A^k05610

lethal - all die during embryonic stage | partially (with Btk29A^k05610)

Btk29A^k00206

lethal - all die during embryonic stage | recessive

viable

Btk29A^ficExc1-16

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Btk29A^GD12363

viable, with Scer\GAL4^Mef2.PR

Btk29A^GD12363

viable, with Scer\GAL4^pnr-MD237

Btk29A^GD12363

viable, with Scer\GAL4^tin.CΔ4

Btk29A^GD12363

Sterility

Allele

female semi-sterile, with Scer\GAL4^nos.PG, Scer\GAL4^VP16.nos.UTR, Scer\GAL4^VP16.otu

Btk29A^GL00027

female semi-sterile, with Scer\GAL4^{VP16.mat.αTub67C}

Btk29A^GL01138

male sterile

Btk29A^fic-P

Other Phenotypes

Allele

abnormal behavior

Btk29A^fic-P

abnormal cell shape

Btk29A^fic-P

abnormal size, with Scer\GAL4^en-e16E

Btk29A^JF01797

short lived

Btk29A^fic-P

some die during embryonic stage | partially (with Btk29A^k00206)

Btk29A^k05610

some die during embryonic stage | partially (with Btk29A^k05610)

Btk29A^k00206

some die during embryonic stage | recessive

some die during first instar larval stage

Btk29A^k05610

wild-type

Phenotype manifest in

Allele

actin cytoskeleton

Btk29A^k00206

actin filament | embryonic stage 5 | germline clone | maternal effect

Btk29A^k00206

actin filament | germline clone

Btk29A^k00206

actin filament bundle | embryonic stage 17

Btk29A^k05610

cephalopharyngeal skeleton

dorsal bridge

egg

egg chamber

egg chamber & actin cytoskeleton | germ-line clone

Btk29A^k00206

embryonic/first instar larval cuticle

Btk29A^k00206

embryonic/first instar larval cuticle (with Btk29A^k00206)

Btk29A^k05610

embryonic/first instar larval cuticle (with Btk29A^k05610)

Btk29A^k00206

embryonic/first instar larval cuticle (with Df(2L)TE29Aa-14)

embryonic/larval muscle system

Btk29A^k00206

embryonic/larval posterior spiracle

Btk29A^k00206

embryonic/larval salivary gland, with Scer\GAL4^fkh.PH

Btk29A^EP2167

embryonic/larval tracheal dorsal trunk | embryonic stage 17

Btk29A^k05610

embryonic/larval tracheal section

Btk29A^k05610

embryonic head

epipharyngeal sclerite

female germline cell

Btk29A^fic-P

filzkorper

Btk29A^k00206

follicle cell

Btk29A^fic-P

germarium, with Scer\GAL4^C587

Btk29A^UAS.cHa

hypostomal sclerite

karyosome | germline clone

Btk29A^k00206

labrum

male genitalia

mouth hook | posterior

nurse cell fusome | germline clone

Btk29A^k00206

nurse cell ring canal

nurse cell ring canal | germline clone

Btk29A^k00206

oocyte | oogenesis stage S14

Btk29A^unspecified

ovary

Btk29A^fic-P

phallapodeme

Btk29A^fic-P

phallapodeme | ectopic

Btk29A^fic-P

phallapodeme | ectopic (with Btk29A^fic-P)

Btk29A^L1-3

phallapodeme | ectopic (with Btk29A^L1-3)

Btk29A^fic-P

posterior ejaculatory duct

Btk29A^fic-P

presumptive embryonic salivary gland

presumptive embryonic salivary gland (with Btk29A^k00206)

Btk29A^k05610

presumptive embryonic salivary gland (with Btk29A^k05610)

Btk29A^k00206

salivary gland common duct primordium

Btk29A^k00206

spectrosome, with Scer\GAL4^C587

Btk29A^UAS.cHa

spiracular chamber

Btk29A^k00206

stigmatophore

Btk29A^k00206

taenidial fold

Btk29A^k05610

taenidial fold | embryonic stage 17

Btk29A^k05610

vertical bridge | anterior

wing | posterior, with Scer\GAL4^en-e16E

Btk29A^JF01797

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (23)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\TEC

12 of 15

Yes

Hsap\TXK

10 of 15

Yes

Hsap\ITK

9 of 15

Yes

Hsap\BTK

8 of 15

Yes

Hsap\BMX

7 of 15

Yes

Hsap\PTK6

3 of 15

Yes

Hsap\SRMS

3 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (22)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Tec

12 of 15

Yes

Mmus\Txk

10 of 15

Yes

Mmus\Itk

9 of 15

Yes

Mmus\Btk

8 of 15

Yes

Mmus\Bmx

7 of 15

Yes

Mmus\Ptk6

3 of 15

Yes

Mmus\Srms

3 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Rattus norvegicus (Norway rat) (20)

Rnor\Itk

9 of 13

Yes

Rnor\Txk

8 of 13

Yes

Rnor\Tec

7 of 13

Yes

Rnor\Bmx

5 of 13

Yes

Rnor\Ptk6

3 of 13

Yes

Rnor\Srms

3 of 13

Yes

Rnor\Blk

2 of 13

Rnor\Btk

2 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

Xenopus tropicalis (Western clawed frog) (20)

Xtro\tec

6 of 12

Yes

Xtro\btk

2 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Xtro\ptk6

1 of 12

Xtro\srms

1 of 12

Xtro\tyk2

1 of 12

Danio rerio (Zebrafish) (23)

Drer\btk

7 of 15

Yes

Drer\tec

7 of 15

Yes

Drer\itk

6 of 15

Yes

Drer\txk

6 of 15

Yes

Drer\ptk6b

3 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

Yes

Drer\si:ch73-340m8.2

2 of 15

Drer\yes1

2 of 15

Drer\zgc:194282

2 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (7)

Cele\src-1

2 of 15

Yes

Cele\src-2

2 of 15

Yes

Cele\Y47G6A.5

2 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

Arabidopsis thaliana (thale-cress) (31)

Atha\AT1G17540

1 of 9

Yes

Atha\AT1G48220

1 of 9

Yes

Atha\AT1G55200

1 of 9

Yes

Atha\AT1G66460

1 of 9

Yes

Atha\AT1G70130

1 of 9

Yes

Atha\AT1G70450

1 of 9

Yes

Atha\AT2G19230

1 of 9

Yes

Atha\AT3G17410

1 of 9

Yes

Atha\AT3G58760

1 of 9

Yes

Atha\AT4G02630

1 of 9

Yes

Atha\AT4G04960

1 of 9

Yes

Atha\AT5G18500

1 of 9

Yes

Atha\AT5G18910

1 of 9

Yes

Atha\AT5G37790

1 of 9

Yes

Atha\AT5G65530

1 of 9

Yes

Atha\CRLK2

1 of 9

Yes

Atha\GPK1

1 of 9

Yes

Atha\PERK1

1 of 9

Yes

Atha\PERK3

1 of 9

Yes

Atha\PERK4

1 of 9

Yes

Atha\PERK5

1 of 9

Yes

Atha\PERK6

1 of 9

Yes

Atha\PERK7

1 of 9

Yes

Atha\PERK15

1 of 9

Yes

Atha\RBK1

1 of 9

Yes

Atha\RBK2

1 of 9

Yes

Atha\RKF1

1 of 9

Yes

Atha\SERK1

1 of 9

Yes

Atha\SRF8

1 of 9

Yes

Atha\SUB

1 of 9

Yes

Atha\VIK

1 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Other Organism Orthologs (via OrthoDB)

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (13)

Gene Symbol

Score

Source

Alignment

Csk

4 of 10

4 of 10

4 of 10

3 of 10

3 of 10

Abl

2 of 10

Ack

2 of 10

FER

2 of 10

CG10702

1 of 10

Fak

1 of 10

hop

1 of 10

Tie

1 of 10

Wsck

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 3 )

Human Ortholog

Disease

Evidence

References

ITK; IL2 inducible T cell kinase

model of lymphoproliferative syndrome 1

IEA

(FlyBase, 2019-)

BTK; Bruton tyrosine kinase

model of isolated growth hormone deficiency type III

IEA

(FlyBase, 2019-)

model of X-linked agammaglobulinemia

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

TEC; tec protein tyrosine kinase

12 of 15

600583

TXK; TXK tyrosine kinase

10 of 15

600058

ITK; IL2 inducible T cell kinase

9 of 15

186973

LYMPHOPROLIFERATIVE SYNDROME 1; LPFS1

lymphoproliferative syndrome 1

BTK; Bruton tyrosine kinase

8 of 15

300300

BMX; BMX non-receptor tyrosine kinase

7 of 15

300101

PTK6; protein tyrosine kinase 6

3 of 15

602004

3 of 15

617797

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Dmel gene

Ortholog showing functional complementation

Supporting References

Btk29A

Hsap\BTK

(Hamada et al., 2005)

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Btk29A - Cad96Ca

two hybrid

(Tsarouhas et al., 2014)

Btk29A - Egfr

two hybrid

(Bianco et al., 2007)

Btk29A - Ptp10D

anti bait coimmunoprecipitation, western blot

(Tsarouhas et al., 2019)

Btk29A - Pvr

two hybrid

(Bianco et al., 2007)

Btk29A - wash

anti tag coimmunoprecipitation, western blot, anti tag western blot

(Tsarouhas et al., 2019)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Btk29A

enhanceable

chic

(Chandrasekaran and Beckendorf, 2005)

Btk29A

suppressible

CycE

(Chandrasekaran and Beckendorf, 2005)

Btk29A|Src42A

suppressible

Jra

(Tateno et al., 2000)

Btk29A

suppressible

pcs

(Hamada-Kawaguchi et al., 2015, Hamada et al., 2005)

Btk29A

enhanceable

Src42A

(Chandrasekaran and Beckendorf, 2005, Tateno et al., 2000)

Btk29A

enhanceable

Src64B

(Chandrasekaran and Beckendorf, 2005)

Btk29A

suppressible

tsr

(Chandrasekaran and Beckendorf, 2005)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

ASPP

suppressible

Btk29A

(Langton et al., 2007)

ASPP|Csk

suppressible

Btk29A

(Langton et al., 2007)

cnk

enhanceable

Btk29A

(Baril et al., 2014)

Csk

suppressible

Btk29A

(Read et al., 2004)

Csk|Stat92E

suppressible

Btk29A

(Read et al., 2004)

DAAM

suppressible

Btk29A

(Matusek et al., 2006)

DAAM

enhanceable

Btk29A

(Matusek et al., 2006)

fzr

suppressible

Btk29A

(Neuert et al., 2017)

suppressible

Btk29A

(Djiane et al., 2013)

pcs

suppressible

Btk29A

(Hamada-Kawaguchi et al., 2015, Beckett and Baylies, 2006, Sinka et al., 2002)

Ras85D

enhanceable

Btk29A

(Schnorr et al., 2001)

Src42A

enhanceable

Btk29A

(Tateno et al., 2000)

Src64B

enhanceable

Btk29A

(Djagaeva, 2005, Djagaeva et al., 2005, Guarnieri et al., 1998, Roulier et al., 1998)

Src64B

suppressible

Btk29A

(Fernández et al., 2014)

tor

suppressible

Btk29A

(Li et al., 2000)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

60259

DroID - A comprehensive database of gene and protein interactions.

FBgn0003502

MIST (genetic) - An integrated Molecular Interaction Database

Btk29A

MIST (protein-protein) - An integrated Molecular Interaction Database

Btk29A

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0003502

External Data

Linkouts

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

MAPK signaling pathway - fly

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-31

Cytogenetic map

29A1-29A3

Sequence location

2L:8,258,373..8,301,079 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

29A1-29A3

Limits computationally determined from genome sequence between P{lacW}l(2)k16919^k16919&P{lacW}Bsg^k09030 and P{lacW}Btk29A^k00206&P{EP}Btk29A^EP715

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

29A-29A

(Guarnieri, 1998.1.21)

29A1-29A2

(determined by in situ hybridisation)

(Spradling et al., 1999)

29A-29A

(determined by in situ hybridisation)

(Baba et al., 1999, Katzen et al., 1990, Vincent et al., 1989, Gregory et al., 1987, Simon et al., 1983)

29A1-29A2

(BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

2-31

(FlyBase, 2016)

2-27.5

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (26)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

43354

w^*; P{GSV1}Btk29A^C184

12580

w¹¹¹⁸; P{GT1}Btk29A^BG01290

82782

y¹ v¹; M{WKO.1-C11}ZH-86Fb

25791

y¹ v¹; P{TRiP.JF01797}attP2

80857

y¹, v¹; P{TKO.GS04761}attP40

77602

w¹¹¹⁸; PBac{IT.GAL4}Btk29A^1254-G4

Kyoto

104342

w^*; P{GawB}Btk29A^NP3020

123289

w¹¹¹⁸; P{RS3}Btk29A^CB-0704-3

103799

w^*; P{GawB}Btk29A^NP0873 / CyO

109037

w¹¹¹⁸; P{BmΔ-w}Btk29A^fic-P / CyO

VDRC

v106962

P{KK100086}VIE-260B

v22675

w¹¹¹⁸; P{GD12363}v22675

More stocks available...

Genomic Clones (43)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (129)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

DPiM_LD16208

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0003502

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0003502

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

34132

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Hamada-Kawaguchi et al., 2014, Tsikala et al., 2014)

monoclonal antibody

(Thomas and Wieschaus, 2004)

monoclonal

(Vincent et al., 1989)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Source for merge of: Btk29A CG18355

(Manning, 2001.10.16)

Additional comments

Other Comments

Btk29A is required non cell-autonomously for the invagination of the spiracular chamber during morphogenesis of the embryonic respiratory system.

(Tsikala et al., 2014)

Btk29A plays a role in the cytoskeletal dynamics that occur during cellularization of the blastoderm.

(Thomas and Wieschaus, 2004)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Btk29A exerts pleiotropic functions in different developmental contexts in different tissues through the generation of distinct forms of protein products by means of alternative splicing.

(Baba et al., 1999)

Btk29A is required for the development of the male genitalia and substrates required for adult survival.

(Baba et al., 1999)

Btk29A is essential for head involution during embryogenesis and ring canal development during oogenesis.

(Roulier et al., 1998)

Phylogenetic analysis of the PTK family.

(Suga et al., 1997)

Both the p55 and p66 products lack a N-terminal myristylation signal. 66kD gene product expressed in Sf9 cells via a recombinant baculovirus has protein tyrosine-kinase activity, but it does not autophosphorylate nor does it use classic 'src' substrates. 55kD gene product expressed in the same system does not exhibit detectable protein tyrosine-kinase activity. A deletion derivative of the 66kD gene product lacking the SH3 and SH2 domains also failed to phosphorylate Sf9 cell proteins.

(Theroux and Wadsworth, 1992)

The mutant stocks studied which show neoplastic growth have structural rearrangements in the Btk29A gene.

(Nabirochkin et al., 1991)

Examination of the expression of Btk29A two major proteins, p66 and p55, suggests that Btk29A plays a role in the development of numerous embryonic and larval tissues.

(Wadsworth et al., 1990)

Structural and biochemical evidence suggest the gene encodes a protein tyrosine kinase.

(Wadsworth, 1990)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 112 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

34132

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

P08630

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P08630

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

P08630

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0003502

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0003502

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34132/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0003502

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0003502

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0003502

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG8049

Flygut - An atlas of the Drosophila adult midgut

FBgn0003502

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0003502

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

34132

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC007809

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG8049

MARRVEL_MODEL - MARRVEL (model organism gene)

34132

modMine - A data warehouse for the modENCODE project

FBgn0003502

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

P08630

Linkouts

BioGRID - A database of protein and genetic interactions.

60259

DroID - A comprehensive database of gene and protein interactions.

FBgn0003502

DRSC - Results frm RNAi screens

FBgn0003502

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0003502

FlyMine - An integrated database for Drosophila genomics

FBgn0003502

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

MAPK signaling pathway - fly

MIST (genetic) - An integrated Molecular Interaction Database

Btk29A

MIST (protein-protein) - An integrated Molecular Interaction Database

Btk29A

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (39)

Reported As

Symbol Synonym

Btk

(Fernández et al., 2014)

Btk29

(Eikenes et al., 2015)

Btk29A

(McLaughlin et al., 2021, La Marca and Richardson, 2020, Lecheta et al., 2020, Overton et al., 2020, Hall et al., 2019, Meltzer et al., 2019, Tsarouhas et al., 2019, Lee et al., 2018, Hamada-Kawaguchi and Yamamoto, 2017, Neuert et al., 2017, Tokusumi et al., 2017, Transgenic RNAi Project members, 2017-, Clandinin and Owens, 2016-, Gene Disruption Project members, 2016-, Hoi et al., 2016, Öztürk-Çolak et al., 2016, Öztürk-Çolak et al., 2016, Sunouchi et al., 2016, Gene Disruption Project members, 2015-, Hamada-Kawaguchi et al., 2015, Kavi et al., 2015, Ashwal-Fluss et al., 2014, Baril et al., 2014, Chen et al., 2014, Faisal et al., 2014, Hamada-Kawaguchi et al., 2014, Sopko et al., 2014, Tsikala et al., 2014, Tutor et al., 2014, Carter, 2013, de Celis et al., 2013.9.11, Djiane et al., 2013, Jagut et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Nawaz et al., 2012, Carreira et al., 2011, Juarez et al., 2011, Hazelett et al., 2009, Southall and Brand, 2009, Akdemir et al., 2007, Asztalos et al., 2007, Bianco et al., 2007, Lecuyer et al., 2007, Minidorff et al., 2007, Minidorff et al., 2007, Quinones-Coello, 2007, Quinones-Coello, 2007, Beckett and Baylies, 2006, Christensen and Cook, 2006.8.30, Christensen and Cook, 2006.12.5, Christensen and Cook, 2006.12.5, Christensen and Cook, 2006.12.5, Edwards et al., 2006, Molnar et al., 2006)

Btk29a

(Sytnikova et al., 2014)

C-src2

C-src4

CG18355

CG8049

(Neuert et al., 2017, Sienski et al., 2012, Ni et al., 2011.7.19, Keleman et al., 2009.8.5, Perkins et al., 2009.1.15, Quinones-Coello, 2007, Quinones-Coello, 2007, Molnar et al., 2006, Metaxakis et al., 2005)

CT2415

(Morrison et al., 2000)

CT41718

(Morrison et al., 2000)

DSrc28

(Palmer et al., 1999)

DTec29

(Palmer et al., 1999)

Dm SRC2

(Gibson and Spring, 1998)

Dsrc28C

(Dobrovolskaia and Belitsky, 1997, Suga et al., 1997, Yamamoto, 1997, Yamamoto et al., 1997, Woods and Bryant, 1993, Theroux and Wadsworth, 1992, Shishido et al., 1991, Wadsworth et al., 1990)

Dsrc29A

(Yamamoto, 1997.12.15, Yamamoto, 1997.12.15, Hoffmann, 1991)

EC2-9

(Baril et al., 2014)

S13

SRC 29A

(Morrison et al., 2000)

Src2

Src29A

(Roulier and Beckendorf, 1998)

Tec

(Lu et al., 2004, Roche, 1998)

Tec29A

(Csiszar et al., 2010, Matusek et al., 2005, Chandrasekaran and Beckendorf, 2004, Schnorr et al., 2001, Li et al., 2000, Jackson and Berg, 1999, Roulier and Beckendorf, 1998)

btk

(Roussou et al., 2019, Langton et al., 2007)

btk29

(Maybeck and Röper, 2009)

btk29A

(Levinson and Cagan, 2016, Tsarouhas et al., 2014, Langton et al., 2007)

btk29a

(McPhee et al., 2010)

c-src/fps

(Nabirochkin et al., 1991)

dsrc29A

(Manning and Krasnow, 1993, Katzen, 1990, Katzen et al., 1990)