sryδ, serendipity delta, sry δ, EH8, sry
Please see the JBrowse view of Dmel\Sry-δ for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.47
Gene model reviewed during 6.61
1.5 (northern blot)
There is only one protein coding transcript and one polypeptide associated with this gene
56 (kD observed)
430 (aa); 50 (kD predicted)
The Sry-δ protein
was shown to specifically bind the "sdcs" consensus sequence in the bcd 5'
protmoter region. Various bcdFBtr0091350:pb-XREcol\lacZ constructs containing bcd
protmoter fragments were tested for their ability to drive expression in the
ovaries. The bcd promoter region which binds Sry-δ is responsible for
nurse cell specific expression.
Homodimer (via ZAD domain) in solution (PubMed:35580610). Binds DNA as a homodimer. N-terminal regions of the protein are required, in addition to the zinc fingers, for the specificity of chromatin-binding.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Sry-δ using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
During early oogenesis, the Sry-delta protein localizes to nurse and follicle cell nuclei. Close inspection of nurse cell nuclei indicates that Sry-delta protein is bound to chromatin. After stage S12 of oogenesis, the protein is found in the oocyte cytoplasm. During embryogenesis, the protein once again becomes nuclear.
During early oogenesis, the Sry-δ protein localizes to nurse and follicle cell nuclei. Close inspection of nurse cell nuclei indicates that Sry-δ protein is bound to chromatin. After stage S12 of oogenesis, the protein is found in the oocyte cytoplasm. During embryogenesis, the protein once again becomes nuclear.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Sry-δ in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
The molecular organization of the 'rp49-Sry-jan' gene cluster, including gene order, direction of transcription and partial overlap of the janA and janB genes is strictly conserved between D.melanogaster and D.pseudoobscura.pseudoobscura.
The Sry-β and Sry-δ genes of D.melanogaster, D.pseudoobscura.pseudoobscura and D.subobscura have been compared both within and between species.
The carboxy-terminal DNA binding finger domain is required and sufficient for binding at specific chromosomal sites but this binding does not nearly reproduce the wild type pattern. An amino-terminal domain is essential to its specificity of in vivo interaction with chromatin. In vitro and in vivo experiments using reciprocal finger swap between Sry-β and Sry-δ proteins suggests that the in vivo specificity is dependent on selective protein-protein contacts at defined chromosomal sites, in addition to DNA specific recognition.
P-element mediated transformation demonstrates that an 18 amino acid segment from the Sry-δ protein contains a nuclear localisation sequence able to direct Ecol\lacZ into the nucleus of all tissues examined. Sequence homology to the SV40 large T and human c-myc NLS suggests that the motif included in the 18 amino acid stretch could be a nuclear localisation signal.
